Dr Duncan Greig
I do experiments with yeast to investigate the process of evolution and to test evolutionary theories. Baker's yeast (Saccharomyces cerevisiae) is an ideal laboratory model organism because it's a sexual eukaryote (just like us), but it reproduces and evolves very quickly, its genome is simple and well defined, and it's easy to genetically engineer. My work spans several research areas including the origin and maintenance of species, the evolution of social cooperation and conflict, sexual selection, and the evolution of sex. I'm interested in the genetics, ecology, and natural history of wild yeast populations, and I collaborate with a mechanical engineer colleague building electrospray devices for manipulating living cells. I'm also interested in the interaction between science and the arts.
A long-term research goal has been to dissect out the genetic causes of sexual sterility in hybrids formed between Saccharomyces cerevisiae and other closely-related yeast species. It's important because hybrid sterility acts as a barrier, preventing different species from mixing and becoming one. I've found that the molecular basis for the species barrier in yeast is quite different from what was expected. In other experiments, I've studied the production of extracellular molecules (beneficial enzymes and harmful toxins) that allow yeast individuals to interact socially with others, in a state of either cooperation or conflict. And recently I've been looking at how yeast uses a sexy chemical signal, a pheromone, to attract mates. The sex pheromone works like a peacock's tail, and we can use it to study how such signals evolve, what information sexual signals convey to potential mates, and what the benefits and costs of signalling (and responding to signals) are.
- Greig D, Fankhauser JD, Rogers DW, Ratcliff WC, Travisano M (2015). Origins of multicellular evolvability in snowflake yeast. Nature Communications, , - .
- Bozdag GO, Greig D (2014). The genetics of a putative social trait in natural populations of yeast. Molecular Ecology, , - .
- Greig D (2014). Spore germination determines yeast inbreeding according to fitness in the local environment. The American Naturalist, University of Chicago Press journal, , - .
- Tazzyman SJ, Seymour RM, Pomiankowski A, Greig D (2012). Mate choice among yeast gametes can purge deleterious mutations.. J Evol Biol, 25(8), 1463 - 1471. doi:10.1111/j.1420-9101.2012.02539.x
- Rogers DW, McConnell E, Greig D (2012). Molecular quantification of Saccharomyces cerevisiae alpha-pheromone secretion. FEMS YEAST RESEARCH, 12(6), 668 - 674. doi:10.1111/j.1567-1364.2012.00817.x
- Maclean CJ, Greig D (2011). Reciprocal gene loss following experimental whole-genome duplication causes reproductive isolation in yeast.. Evolution, 65(4), 932 - 945. doi:10.1111/j.1558-5646.2010.01171.x
- Smith C, Greig D (2010). The cost of sexual signaling in yeast.. Evolution, 64(11), 3114 - 3122. doi:10.1111/j.1558-5646.2010.01069.x
- MacLean RC, Fuentes-Hernandez A, Greig D, Hurst LD, Gudelj I (2010). A Mixture of "Cheats'' and "Co-Operators'' Can Enable Maximal Group Benefit. PLOS BIOL, 8(9), - . doi:10.1371/journal.pbio.1000486
- Greig D, Leu JY (2009). Natural history of budding yeast.. Curr Biol, 19(19), R886 - R890. doi:10.1016/j.cub.2009.07.037
- Maclean CJ, Greig D (2008). Prezygotic reproductive isolation between Saccharomyces cerevisiae and Saccharomyces paradoxus. BMC Evolutionary Biology, 8(1), - . doi:10.1186/1471-2148-8-1
- Replansky T, Koufopanou V, Greig D, Bell G (2008). Saccharomyces sensu stricto as a model system for evolution and ecology.. Trends in Ecology and Evolution, 23(9), 494 - 501. doi:10.1016/j.tree.2008.05.005
- Greig D, Jayasinghe SN (2008). Genomic, genetic and physiological effects of bio-electrospraying on live cells of the model yeast Saccharomyces cerevisiae. Biomedical Materials, , - .
- Greig D, Travisano M (2008). Density-dependent effects on allelopathic interactions in yeast.. Evolution, 62(3), 521 - 527. doi:10.1111/j.1558-5646.2007.00292.x
- Replansky T, Koufopanou V, Greig D, Bell G (2008). Saccharomyces sensu stricto as a model system for evolution and ecology. TRENDS ECOL EVOL, 23(9), 494 - 501. doi:10.1016/j.tree.2008.05.005
- McBride R, Greig D, Travisano M (2008). Fungal-viral mutualism moderated by ploidy.. Evolution, 62(9), 2372 - 2380. doi:10.1111/j.1558-5646.2008.00443.x
- Greig D (2008). Reproductive isolation in Saccharomyces. Heredity, , - . doi:10.1038/hdy.2008.73
- Rogers DW, Greig D (2008). Experimental evolution of a sexually selected display. Proceedings of the Royal Society B: Biological Sciences, , - . doi:10.1098/rspb.2008.1146
- Greig D (2007). A screen for recessive speciation genes expressed in the gametes of F1 hybrid yeast.. PLoS Genetics, 3(2), e21 - . doi:10.1371/journal.pgen.0030021
- Reuter M, Bell G, Greig D (2007). Increased outbreeding in yeast in response to dispersal by an insect vector. CURR BIOL, 17(3), R81 - R83.
- Greig D (2007). Population biology: Wild origins of a model yeast. Current Biology, 17(7), R251 - R253. doi:10.1016/j.cub.2007.02.009
- Reuter M, Bell G, Greig D (2007). Increased outbreeding in yeast in response to dispersal by an insect vector. Current Biology, 17, R81 - R83. doi:10.1016/j.cub.2006.11.059
- Greig D, Travisano M (2004). The Prisoner's Dilemma and polymorphism in yeast SUC genes. Proceedings of the Royal Society B: Biological Sciences, 271(Suppl. 3), S25 - S26. doi:10.1098/rsbl.2003.0083
- Greig D, Travisano M, Louis EJ, Borts RH (2003). A role for the mismatch repair system during incipient speciation in Saccharomyces.. J Evol Biol, 16(3), 429 - 437.
- Greig D, Travisano M, Louis EJ, Borts RH (2003). A role for the mismatch repair system during A role for the mismatch repair system during incipient speciation in Saccharomyces. Journal of Evolutionary Biology, 16, 429 - 437. doi:10.1046/j.1420-9101.2003.00546.x
- Greig D, Travisano M (2003). Haploid superiority. Science, 299, 524 - 525. doi:10.1126/science.1081275
- Greig D, Borts RH, Louis EJ, Travisano M (2002). Epistasis and hybrid sterility in Saccharomyces. Proceedings of the Royal Society B: Biological Sciences, 169, 1167 - 1171. doi:10.1098/rspb.2002.1989
- Greig D, Louis EJ, Borts RH, Travisano M (2002). Hybrid speciation in experimental populations of yeast. Science, 298, 1773 - 1775. doi:10.1126/science.1076374
- Goddard MR, Greig D, Burt A (2001). Outcrossed sex allows a selfish gene to invade yeast populations. Proceedings of the Royal Society B: Biological Sciences, 268, 2537 - 2542.
- Greig D, Borts RH, Louis EJ (1998). The effect of sex on adaptation to high temperature in heterozygous and homozygous yeast. Proceedings of the Royal Society B: Biological Sciences, 265, 1017 - 1023. doi:10.1098/rspb.1998.0393
- David P, Hingle A, Greig D, Rutherford A, Pomiankowski A, Fowler K (1998). Male sexual ornament size but not asymmetry reflects condition in stalk-eyed flies. Proceedings of the Royal Society B: Biological Sciences, 265, 2211 - 2216.
- Stelkens RB, Brockhurst MA, Greig D, Hurst GDD (). Hybridization facilitates evolutionary rescue. Evolutionary Applications, , - .
- Stelkens RB, Brockhurst MA, Hurst GDD, Miller EL, Greig D (). The effect of hybrid transgression on environmental tolerance in experimental yeast crosses. Journal of Evolutionary Biology, , - .
- Boynton PJ, Greig D (). The ecology and evolution of non-domesticated Saccharomyces species. Yeast, , - .