Dr Adam Giangreco

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Personal Profile

Name: Adam Giangreco Email: a.giangreco@ucl.ac.uk
Title: Dr Tel: 020 7679 6926
Department: Internal Medicine Fax: 044
Position: Senior Research Associate Address: Rayne Institute 5 University Street London, , London, WC1E 6JF
Research Domain: Ageing, Biomedical Imaging (Frontier Disciplines), Cancer, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

Profile

Research Description

Irreversible lung damage is a leading cause of death and disease, costing the UK economy billions of pounds per year. Diseases caused by irreversible lung damage include squamous, small and non-small cell lung cancers, chronic obstructive pulmonary disease, and various  heritable and spontaneous genetic disorders. Unfortunately treatment options for lung disease remain limited and survival rates for lung cancer in particular have not improved for over 60 years. 

The goal of my laboratory's research is to increase our understanding of the fundamental mechanisms driving lung cancer and lung regeneration.  We hope to exploit this knowledge in order to develop more effective treatments for repairing irreversibly damaged lungs.

Please visit my lab's website for more information:

http://www.ucl.ac.uk/silva/medicine/respiratory-research/staff/adam-giangreco


Research Activities

Stem cells in lung regeneration and cancer

Education Description

UCL Collaborators

External Collaborators

Publications

    2013

    • Lu L, Teixeira VH, Yuan Z, Graham TA, Endesfelder D, Kolluri K, Al-Juffali N, Hamilton N, Nicholson AG, Falzon M, Kschischo M, Swanton C, Wright NA, Carroll B, Watt FM, George JP, Jensen KB, Giangreco A, Janes SM (2013). LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.. J Pathol, 229(4), 608 - 620. doi:10.1002/path.4148

    2012

    • Giangreco A, Hoste E, Takai Y, Rosewell I, Watt FM (2012). Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity.. J Immunol, 188(3), 1514 - 1522. doi:10.4049/jimmunol.1003342
    • Hynds RE, Giangreco A (2012). The Relevance of Human Stem Cell-Derived Organoid Models for Epithelial Translational Medicine. Stem Cells, , - . doi:10.1002/stem.1290
    • Butler C, Birchall M, Giangreco A (2012). Interventional and intrinsic airway homeostasis and repair.. Physiology (Bethesda), 27(3), 140 - 147. doi:10.1152/physiol.00001.2012
    • Giangreco A, Lu L, Vickers C, Teixeira VH, Groot KR, Butler CR, Ilieva EV, George PJ, Nicholson AG, Sage EK, Watt FM, Janes SM (2012). β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. Journal of Pathology, 226(4), 575 - 587.
    • Sage EK, McNulty K, Kolluri K, Giangreco A, Janes SM (2012). MSCTRAIL AS A NOVEL CELLULAR THERAPY FOR MALIGNANT MESOTHELIOMA. doi:10.1136/thoraxjnl-2012-202678.002
    • Giangreco A, Lu L, Vickers C, Teixeira VH, Groot KR, Butler CR, Ilieva EV, George PJ, Nicholson AG, Sage EK, Watt FM, Janes SM (2012). β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition.. J Pathol, 226(4), 575 - 587. doi:10.1002/path.3962

    2011

    • Giangreco A, Lu L, Mazzatti DJ, Spencer-Dene B, Nye E, Teixeira VH, Janes SM (2011). Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance.. J Pathol, 224(2), 190 - 202. doi:10.1002/path.2876
    • Sage E, Kolluri K, Giangreco A, Janes S (2011). MESENCHYMAL STEM CELLS EXPRESSING TRAIL INDUCE APOPTOSIS IN MALIGNANT PLEURAL MESOTHELIOMA. doi:10.1136/thoraxjnl-2011-201054b.60
    • Giangreco A, Lu L, Vickers C, Ilieva E, Groot K, George J, Nicholson A, Sage E, Watt F, Janes S (2011). BETA-CATENIN DETERMINES TRACHEAL CELL FATE AND SQUAMOUS LUNG CANCER PROGRESSION BY MODULATING INTERCELLULAR ADHESIVENESS. doi:10.1136/thoraxjnl-2011-201054b.58
    • Giangreco A, Lu L, Mazzatti D, Spencer-Dene B, Nye E, Teixeira V, Janes S (2011). MYD88 DEFICIENCY INFLUENCES MURINE TRACHEAL EPITHELIAL METAPLASIA AND SUBMUCOSAL GLAND ABUNDANCE. doi:10.1136/thoraxjnl-2011-201054b.37

    2010

    • Giangreco A, Goldie SJ, Failla V, Saintigny G, Watt FM (2010). Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP.. J Invest Dermatol, 130(2), 604 - 608. doi:10.1038/jid.2009.297

    2009

    • Zemke AC, Teisanu RM, Giangreco A, Drake JA, Brockway BL, Reynolds SD, Stripp BR (2009). β-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. American Journal of Respiratory Cell and Molecular Biology, 41(5), 535 - 543.
    • Zemke AC, Teisanu RM, Giangreco A, Drake JA, Brockway BL, Reynolds SD, Stripp BR (2009). beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.. Am J Respir Cell Mol Biol, 41(5), 535 - 543. doi:10.1165/rcmb.2008-0407OC
    • Giangreco A, Jensen KB, Takai Y, Miyoshi J, Watt FM (2009). Necl2 regulates epidermal adhesion and wound repair.. Development, 136(20), 3505 - 3514. doi:10.1242/dev.038232
    • Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR (2009). Stem cells are dispensable for lung homeostasis but restore airways after injury.. Proc Natl Acad Sci U S A, 106(23), 9286 - 9291. doi:10.1073/pnas.0900668106
    • Driskell RR, Giangreco A, Jensen KB, Mulder KW, Watt FM (2009). Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis.. Development, 136(16), 2815 - 2823. doi:10.1242/dev.038620

    2008

    • Giangreco A, Qin M, Pintar JE, Watt FM (2008). Epidermal stem cells are retained in vivo throughout skin aging.. Aging Cell, 7(2), 250 - 259. doi:10.1111/j.1474-9726.2008.00372.x
    • Loebinger MR, Giangreco A, Groot KR, Prichard L, Allen K, Simpson C, Bazley L, Navani N, Tibrewal S, Davies D, Janes SM (2008). Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade.. Br J Cancer, 98(2), 380 - 387. doi:10.1038/sj.bjc.6604185
    • Reynolds SD, Zemke AC, Giangreco A, Brockway BL, Teisanu RM, Drake JA, Mariani T, Di PY, Taketo MM, Stripp BR (2008). Conditional stabilization of beta-catenin expands the pool of lung stem cells.. Stem Cells, 26(5), 1337 - 1346. doi:10.1634/stemcells.2008-0053

    2007

    • Giangreco A, Groot KR, Janes SM (2007). Lung cancer and lung stem cells: strange bedfellows?. Am J Respir Crit Care Med, 175(6), 547 - 553. doi:10.1164/rccm.200607-984PP

    2006

    • Nijhof JG, Braun KM, Giangreco A, van Pelt C, Kawamoto H, Boyd RL, Willemze R, Mullenders LH, Watt FM, de Gruijl FR, van Ewijk W (2006). The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells.. Development, 133(15), 3027 - 3037. doi:10.1242/dev.02443

    2005

    • Silva-Vargas V, Lo Celso C, Giangreco A, Ofstad T, Prowse DM, Braun KM, Watt FM (2005). Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells.. Dev Cell, 9(1), 121 - 131. doi:10.1016/j.devcel.2005.04.013
    • Nijhof J, Braun K, Giangreco A, Van Pelt C, Kawamoto H, Boyd R, Willemze R, Mullenders L, De Gruijl F, Van Ewijk W (2005). MTS24 expression delineates a population of murine hair follicle keratinocytes with stem cell characteristics.
    • Reynolds SD, Giangreco A, Stripp BR (2005). Genetically modified mouse models of lung injury and repair. In Notter RH (Ed.), Lung injury mechanisms, pathophysiology, and therapy (pp. - ). : Informa HealthCare.
    • Silva-Vargas V, Lo Celso C, Giangreco A, Ofstad T, Prowse DM, Braun KM, Watt FM (2005). β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Developmental Cell, 9(1), 121 - 131.

    2004

    • Giangreco A, Shen H, Reynolds SD, Stripp BR (2004). Molecular phenotype of airway side population cells.. Am J Physiol Lung Cell Mol Physiol, 286(4), L624 - L630. doi:10.1152/ajplung.00149.2003
    • Reynolds SD, Giangreco A, Hong KU, McGrath KE, Ortiz LA, Stripp BR (2004). Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction.. Am J Physiol Lung Cell Mol Physiol, 287(6), L1256 - L1265. doi:10.1152/ajplung.00203.2004

    2002

    • Giangreco A, Reynolds SD, Stripp BR (2002). Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction.. Am J Pathol, 161(1), 173 - 182. doi:10.1016/S0002-9440(10)64169-7

    2001

    • Hong KU, Reynolds SD, Giangreco A, Hurley CM, Stripp BR (2001). Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion.. Am J Respir Cell Mol Biol, 24(6), 671 - 681. doi:10.1165/ajrcmb.24.6.4498
    • Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N (2001). Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1.. Mol Pharmacol, 60(5), 1091 - 1099.
    • Giangreco A, Sowden MP, Mikityansky I, Smith HC (2001). Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis.. Biochem Biophys Res Commun, 289(5), 1162 - 1167. doi:10.1006/bbrc.2001.6082

    2000

    • Reynolds SD, Hong KU, Giangreco A, Mango GW, Guron C, Morimoto Y, Stripp BR (2000). Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells.. Am J Physiol Lung Cell Mol Physiol, 278(6), L1256 - L1263.
    • Reynolds SD, Giangreco A, Power JH, Stripp BR (2000). Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration.. Am J Pathol, 156(1), 269 - 278. doi:10.1016/S0002-9440(10)64727-X

    1999

    • Hong KU, Reynolds SD, Giangreco A, Guron CG, Murimoto Y, Mango GW, Stripp BR (1999). CCSP-HSVtk transgenic mice for delineation of airway stem cell heirarchy.. AM J RESP CRIT CARE, 159(3), A507 - A507.
    • Reynolds SD, Giangreco A, Power JHT, Stripp BR (1999). Two spatially related stem cell populations participate in regeneration of the airway following Clara cell ablation.. AM J RESP CRIT CARE, 159(3), A439 - A439.

    • Giangreco A (). Epidermal stem cell isolation facilitates the study of keratinocyte differentiation potential.
    • Giangreco A (). Wnt signalling is involved in growth and differentiation of the distal airway epithelium during lung development.
    • Giangreco A (). Do lungs really need stem cells?.
    • Giangreco A, Rosewell I (). Murine aggregation chimeras and wholemount imaging in airway stem cell biology. In Braun KM, Mace K (Ed.), Emerging methods in progenitor cell biology: a multisystemic overview (Methods in Molecular Biology) (pp. - ). : .
    • Giangreco A (). Lung stem cells and lineage selection in the airway.
    • Giangreco A (). Lung stem cells and airway lineage selection.
    • Giangreco A (). Airway stem cells and regenerative medicine: How can we accelerate innovation?.
    • Giangreco A (). Airway stem cells, regeneration, and lung disease.
    • Giangreco A (). Chimera studies of lung development and repair.
    • Giangreco A (). The consequences of stem cell-mediated airway regeneration.
    • Giangreco A (). Defining characteristics of airway stem cell niches.
    • Giangreco A (). Assessing lung stem cell functionality using wholemount imaging.
    • Giangreco A (). Stem cells are dispensable for normal airway homeostasis but contribute to repair following acute lung injury.
    • Giangreco A (). Terminal bronchioles harbor a stem cell population that localizes to the bronchio-alveolar duct junction.
    • Giangreco A (). Stem cells are dispensable for lung homeostasis but restore airways after injury.