Prof Alan Salama

Photo

Personal Profile

Name: Alan Salama Email: a.salama@ucl.ac.uk
Title: Prof Tel: 020 77940500 36007
Department: Internal Medicine Fax: 020 78302653
Position: Professor of Nephrology Address: Centre for Nephrology, 2nd Floor, Royal Free Campus, Rowland Hill Street, London, NW3 2PF
Research Domain: Experimental Medicine, Infection, Immunology & Inflammation, London, Personalised Medicine, Populations & Lifelong Health Web Page:  

Profile

Research Description

My research is focused on understanding and manipulating mechanisms of immune regulation in systemic autoimmune vasculitis and transplantation. We have investigated novel pathways involved in lymphocyte and monocyte/macrophage regulation and the interaction between innate and adaptive immune responses.

Research Activities

ANCA-associated systemic vasculitis

Immunology of glomerulonephritis and transplantation

Education Description

UCL Collaborators

Dr Stephen Marks; Dr Mark Little; Prof Christopher Denton; Dr Paul Brogan; Prof Susan Lightman

External Collaborators

Dr Mike Robson; Prof Lorarine Harper

Publications

    2014

    • Evans R, Salama AD (2014). Update on Rituximab: An Established Treatment for All Immune-Mediated Kidney Diseases?. NEPHRON CLINICAL PRACTICE, 126(3), 97 - 109. doi:10.1159/000358887
    • Salama AD, Rees AJ (2014). Autoantibodies in anti-neutrophil cytoplasm antibody-associated vasculitis. NEPHROLOGY DIALYSIS TRANSPLANTATION, 29(6), 1105 - 1107. doi:10.1093/ndt/gft526
    • Lavainne F, Meffray E, Néel M, Fakhouri F, Delcroix C, Pepper RJ, Salama AD (2014). Heparin use during dialysis sessions induces an increase in the antiangiogenic factor soluble Flt1. Nephrology Dialysis Transplantation, 29(6), 1225 - 1231. doi:10.1093/ndt/gft517
    • Cherukuri A, Rothstein DM, Clark B, Carter CR, Davison A, Hernandez-Fuentes M, Hewitt E, Salama AD, Baker RJ (2014). Immunologic Human Renal Allograft Injury Associates with an Altered IL-10/TNF-alpha Expression Ratio in Regulatory B Cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 25(7), 1575 - 1585. doi:10.1681/ASN.2013080837

    2013

    • derrett-smith E, Nihtyanova S, harvey J, Salama AD, denton C (2013). Revisiting ANCA-associated vasculitis in systemic sclerosis: clinical, serological and immunogenetic factors. Rheumatology, , - .
    • Pepper RJ, Hamour S, Chavele KM, Rasmussen N, Flint S, Lyons PA, Smith KGC, Pusey CD, Cook HT, Salama AD (2013). Calprotectin has a pathogenic pro-inflammatory role in anti-neutrophil cytoplasmic antibody associated vasculitis and glomerulonephritis.
    • Pepper RJ, Chanouzas D, Tarzi R, Little M, Caisian A, Walsh M, Pusey CD, Harper L, Salama AD, EUVAS Investigators (2013). Intravenous Cyclophosphamide and Plasmapheresis in Dialysis-Dependent ANCA-Associated Vasculitis. Clinical Journal of the American Society of Nephrology, 8, - .
    • Pepper RJ, Salama AD (2013). Practical immunosuppression. In (Ed.), Practical Nephrology (pp. - ). : Springer.
    • Salama AD (2013). Anti- glomerular basement membrane disease. In (Ed.), Practical Nephrology (pp. - ). : Springer.
    • Salama AD (2013). Anti-glomerular basement membrane disease. In Lin J, Fervenza F (Ed.), Core concepts in Parenchymal Kidney Disease (pp. - ). : Springer.

    2012

    • Pepper RJ, Hamour S, Chavele KM, Rasmussen N, Flint S, Lyons PA, Smith KGC, Pusey CD, Cook HT, Salama AD (2012). Leukocyte and serum calprotectin (S100A8/S100A9) expression reflect disease activity in ANCA associated vasculitis and glomerulonephritis. Kidney International, In Press, - .
    • Reynolds J, Cook PR, Behmoaras J, Smith J, Bhangal G, Tadros S, Tee J, Salama AD, Evans DJ, Aitman TJ, Cook HT, Pusey CD (2012). Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat.. Am J Pathol, 180(5), 1843 - 1851.
    • McAdoo SP, Hall A, Levy J, Salama AD, Pusey CD (2012). Proteinase-3 antineutrophil cytoplasm antibody positivity in patients without primary systemic vasculitis.. J Clin Rheumatol, 18, 336 - 340.
    • Virk JS, Stamatoglou C, Kwame I, Salama AD, Sandison A, Sandhu G (2012). Pseudotumor of the Trachea: A Case Report and Review of the Literature.. Arch Otolaryngol Head Neck Surg., 138, 864 - 868.
    • Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahey M, Salama A, Wheeler DC, Leiper J (2012). Alanine-Glyoxylate Aminotransferase-2 Metabolizes Endogenous Methylarginines, Regulates NO, and Controls Blood Pressure.. Arterioscler Thromb Vasc Biol, 2012 Sep 27. [Epub ahead of print], - .
    • Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L, Gunnarsson I, Harper L, Hrušková Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders JS, Savage CO, Segelmark M, Stegeman CA, Tesař V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG, Smith KG (2012). Genetically distinct subsets within ANCA-associated vasculitis.. N Engl J Med, 367(3), 214 - 223. doi:10.1056/NEJMoa1108735
    • Guerry MJ, Brogan P, Bruce IN, D'Cruz DP, Harper L, Luqmani R, Pusey CD, Salama AD, Scott DG, Savage CO, Watts RA, Jayne DR (2012). Recommendations for the use of rituximab in anti-neutrophil cytoplasm antibody-associated vasculitis.. Rheumatology (Oxford), 51(4), 634 - 643. doi:10.1093/rheumatology/ker150
    • Cherukuri A, Salama AD, Carter C, Smalle N, McCurtin R, Hewitt EW, Hernandez-Fuentes M, Clark B, Baker RJ (2012). An analysis of lymphocyte phenotype after steroid avoidance with either alemtuzumab or basiliximab induction in renal transplantation.. Am J Transplant, 12(4), 919 - 931. doi:10.1111/j.1600-6143.2011.03891.x
    • Salama AD, Little MA (2012). Animal models of antineutrophil cytoplasm antibody-associated vasculitis.. Curr Opin Rheumatol, 24(1), 1 - 7. doi:10.1097/BOR.0b013e32834d2d52
    • Hong Y, Eleftheriou D, Hussain AA, Price-Kuehne FE, Savage CO, Jayne D, Little MA, Salama AD, Klein NJ, Brogan PA (2012). Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles.. J Am Soc Nephrol, 23(1), 49 - 62. doi:10.1681/ASN.2011030298
    • Le Roux S, Pepper RJ, Dufay A, Néel M, Meffray E, Lamandé N, Rimbert M, Josien R, Hamidou M, Hourmant M, Cook HT, Charreau B, Larger E, Salama AD, Fakhouri F (2012). Elevated soluble Flt1 inhibits endothelial repair in PR3-ANCA-associated vasculitis.. J Am Soc Nephrol, 23(1), 155 - 164. doi:10.1681/ASN.2010080858
    • Reynolds J, Sando GS, Marsh OB, Salama AD, Evans DJ, Cook HT, Pusey CD (2012). Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis.. Nephrol Dial Transplant, 27(4), 1343 - 1350. doi:10.1093/ndt/gfr529
    • Pepper RJ, Salama AD (2012). Classifying and predicting outcomes in ANCA-associated glomerulonephritis.. Nephrol Dial Transplant, 27(6), 2135 - 2137. doi:10.1093/ndt/gfs062

    2011

    • Salama AD, Cook HT (2011). Brenner and Rector's the Kidney The Kidney Biopsy. In Taal MW, Chertow GM, Marsden PA, Skorecki K, Yu ASL (Ed.), Brenner and Rector's the Kidney (pp. - ). : W B Saunders Co.
    • Salama AD, Little M (2011). Oxford textbook of rheumatology Kidney involvement in rheumatologic diseases. In Isenberg DA, Isenberg D (Ed.), Oxford textbook of rheumatology (pp. - ). : Oxford University Press, USA.
    • Wang HH, Salama AD, Hamour S, Pepper R, Little M (2011). MANNOSE RECEPTOR DEFICIENCY PROTECTS MICE FROM ISCHEMIC-REPERFUSION INJURY AND NEPHROTOXIC NEPHRITIS.
    • Morris H, Morgan MD, Wood AM, Smith SW, Ekeowa UI, Herrmann K, Holle JU, Guillevin L, Lomas DA, Perez J, Pusey CD, Salama AD, Stockley R, Wieczorek S, McKnight AJ, Maxwell AP, Miranda E, Williams J, Savage CO, Harper L (2011). ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.. Ann Rheum Dis, 70(10), 1851 - 1856. doi:10.1136/ard.2011.153569
    • Pepper RJ, Tarzi R, Wang HH, Pusey CD, Cook HT, Salama AD (2011). Critical role for calprotectin in ANCA-AAV and GN.
    • Pepper RJ, Chanouzas D, Tarzi R, Harper L, Pusey CD, Salama AD (2011). Renal outcomes in patients presenting with dialysis-dependent ANCA-AAV treated with pulsed intravenous CyP.
    • Arulkumaran N, Periselneris N, Gaskin G, Strickland N, Ind PW, Pusey CD, Salama AD (2011). Interstitial lung disease and ANCA-associated vasculitis: a retrospective observational cohort study.. Rheumatology (Oxford), 50(11), 2035 - 2043. doi:10.1093/rheumatology/ker236
    • Holden NJ, Williams JM, Morgan MD, Challa A, Gordon J, Pepper RJ, Salama AD, Harper L, Savage CO (2011). ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process.. Ann Rheum Dis, 70(12), 2229 - 2233. doi:10.1136/ard.2011.153890
    • Arulkumaran N, Jawad S, Smith SW, Harper L, Brogan P, Pusey CD, Salama AD (2011). Long- term outcome of paediatric patients with ANCA vasculitis.. Pediatr Rheumatol Online J, 9, 12 - . doi:10.1186/1546-0096-9-12
    • Peto P, Salama AD (2011). Update on antiglomerular basement membrane disease.. Curr Opin Rheumatol, 23(1), 32 - 37. doi:10.1097/BOR.0b013e328341009f
    • Arulkumaran N, West SC, Ind PW, Gaskin G, Tarzi R, Salama AD, Pusey CD (2011). ANCA-AAV and PH.
    • Salama AD (2011). B cells in the induction of human autoimmune vasculitis.
    • Arulkumaran N, Periselneris N, Gaskin G, Strickland N, Ind PW, Pusey CD, Salama AD (2011). MPO-ANCA-AAV with pulmonary fibrosis.
    • Hamour SM, Salama AD (2011). ANCA comes of age-but with caveats.. Kidney Int, 79(7), 699 - 701. doi:10.1038/ki.2010.558
    • Mansfield N, Hamour S, Habib AM, Tarzi R, Levy J, Griffith M, Cairns T, Cook HT, Pusey CD, Salama AD (2011). Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis.. Nephrol Dial Transplant, 26(10), 3280 - 3286. doi:10.1093/ndt/gfr127
    • Joshi L, Lightman SL, Salama AD, Shirodkar AL, Pusey CD, Taylor SR (2011). Rituximab in refractory ophthalmic Wegener's granulomatosis: PR3 titers may predict relapse, but repeat treatment can be effective.. Ophthalmology, 118(12), 2498 - 2503. doi:10.1016/j.ophtha.2011.06.009

    2010

    • Nogueira E, Hamour S, Sawant D, Henderson S, Mansfield N, Chavele KM, Pusey CD, Salama AD (2010). Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis. NEPHROL DIAL TRANSPL, 25(7), 2209 - 2217. doi:10.1093/ndt/gfp783
    • Chavele KM, Martinez-Pomares L, Domin J, Pemberton S, Haslam SM, Dell A, Cook HT, Pusey CD, Gordon S, Salama AD (2010). Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.. J Clin Invest, 120(5), 1469 - 1478. doi:10.1172/JCI41560
    • Chrysochou C, Power A, Shurrab AE, Husain S, Moser S, Lay J, Salama AD, Kalra PA (2010). Low risk for nephrogenic systemic fibrosis in nondialysis patients who have chronic kidney disease and are investigated with gadolinium-enhanced magnetic resonance imaging.. Clin J Am Soc Nephrol, 5(3), 484 - 489. doi:10.2215/CJN.06580909
    • Chavele KM, Shukla D, Keteepe-Arachi T, Seidel JA, Fuchs D, Pusey CD, Salama AD (2010). Regulation of myeloperoxidase-specific T cell responses during disease remission in antineutrophil cytoplasmic antibody-associated vasculitis: the role of Treg cells and tryptophan degradation.. Arthritis Rheum, 62(5), 1539 - 1548. doi:10.1002/art.27403
    • Nogueira E, Hamour S, Sawant D, Henderson S, Mansfield N, Chavele KM, Pusey CD, Salama AD (2010). Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis.. Nephrol Dial Transplant, 25(7), 2209 - 2217. doi:10.1093/ndt/gfp783
    • Annear NM, Cook HT, Atkins M, Pusey CD, Salama AD (2010). Non-hepatitis virus associated mixed essential cryoglobulinemia.. Kidney Int, 77(2), 161 - 164. doi:10.1038/ki.2009.416
    • Salama AD, Cook HT (2010). Comment on "Non-hepatitis virus-associated mixed essential cryoglobulinemia'' Reply. KIDNEY INT, 78(1), 114 - 114. doi:10.1038/ki.2010.127
    • Hamish M, Geroulakos G, Hughes DA, Moser S, Shepherd A, Salama AD (2010). Delayed hepato-spleno-renal bypass for renal salvage following malposition of an infrarenal aortic stent-graft.. J Endovasc Ther, 17(3), 326 - 331. doi:10.1583/09-3011.1
    • Nogueira EL, Ind PW, Friedland JS, Salama AD (2010). Mucormycosis may mimic disease relapse in Wegener's granulomatosis.. J Rheumatol, 37(6), 1364 - 1365. doi:10.3899/jrheum.091423
    • Basu N, Watts R, Bajema I, Baslund B, Bley T, Boers M, Brogan P, Calabrese L, Cid MC, Cohen-Tervaert JW, Flores-Suarez LF, Fujimoto S, de Groot K, Guillevin L, Hatemi G, Hauser T, Jayne D, Jennette C, Kallenberg CG, Kobayashi S, Little MA, Mahr A, McLaren J, Merkel PA, Ozen S, Puechal X, Rasmussen N, Salama A, Salvarani C, Savage C, Scott DG, Segelmark M, Specks U, Sunderköetter C, Suzuki K, Tesar V, Wiik A, Yazici H, Luqmani R (2010). EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis.. Ann Rheum Dis, 69(10), 1744 - 1750. doi:10.1136/ard.2009.119032
    • Hamour S, Salama AD, Pusey CD (2010). Management of ANCA-associated vasculitis: Current trends and future prospects.. Ther Clin Risk Manag, 6, 253 - 264.
    • Salama AD, Hernandes-Fuentes M (2010). Transplantation Immunology. In Hornick P (Ed.), Transplantation Immunology (pp. - ). : Humana Pr Inc.

    2009

    • Peters JE, Salama AD, Ind PW (2009). Wegener's granulomatosis presenting as acute systemic vasculitis following 20 years of limited tracheobronchial disease.. J Laryngol Otol, 123(12), 1375 - 1377. doi:10.1017/S002221510900454X
    • Salama AD (2009). Crescentic Glomerulonephritis. In Barratt J, Topham P, Harris K (Ed.), Oxford Desk Reference: Nephrology (pp. - ). : Oxford University Press, USA.
    • Salama AD (2009). Management of Acute Kidney Problems. In Jörres A (Ed.), Management of Acute Kidney Problems (pp. - ). : Springer Verlag.
    • Chavele KM, Martinez-Pomares L, Gordon S, Cook T, Pusey C, Salama A (2009). Circulating mannose receptor is elevated in acute ANCA-associated vasculitis and contributes in the development of experimental glomerulonephritis.
    • Mansfield N, Hamour S, Nogueira E, Habib AM, Pusey C, Cairns T, Griffith M, Levy J, Gaskin G, Salama AD (2009). CycLowVas: a rituximab (RTX)-based cyclophosphamide (CYP)-sparing regime.
    • Henderson SR, Copley SJ, Ind PW, Salama AD (2009). Effective treatment of granulomatous lesions in Wegener's granulomatosis with rituximab.
    • Kamesh L, Heward JM, Williams JM, Gough SC, Chavele KM, Salama A, Pusey C, Savage CO, Harper L (2009). CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis.. Rheumatology (Oxford), 48(12), 1502 - 1505. doi:10.1093/rheumatology/kep280
    • Jones RB, Ferraro AJ, Chaudhry AN, Brogan P, Salama AD, Smith KG, Savage CO, Jayne DR (2009). A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis.. Arthritis Rheum, 60(7), 2156 - 2168. doi:10.1002/art.24637
    • Salama AD, Pusey CD (2009). Shining a LAMP on pauci-immune focal segmental glomerulonephritis.. Kidney Int, 76(1), 15 - 17. doi:10.1038/ki.2009.123
    • Sangha G, Al-Ani B, Al-Nuaimi H, Mukherjee S, Salama A, Pusey C, Little M (2009). Absence of myeloperoxidase renal deposition in rat experimental autoimmune vasculitis.
    • Kai A, Espinel-Costoso L, Trivedi S, Casal A, Morgan M, Levy J, Little MA, Pusey C, Jayne D, Salama AD (2009). Outcomes of a UK cohort of AAV patients treated with TNF blockade.
    • Hamour S, Salama AD (2009). 17 and 23: prime numbers that matter.. J Am Soc Nephrol, 20(5), 925 - 927. doi:10.1681/ASN.2009030291
    • Taylor SR, Salama AD, Joshi L, Pusey CD, Lightman SL (2009). Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis. Arthritis Rheum., 60(5), 1540 - 1547.
    • Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, Nourshargh S, Cook HT, Pusey CD (2009). Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.. Am J Pathol, 174(4), 1212 - 1220. doi:10.2353/ajpath.2009.080458
    • Joshi L, Hamour S, Salama AD, Pusey CD, Lightman S, Taylor SR (2009). Renal & ocular targets for therapy in Wegener's granulomatosis.. Inflamm Allergy Drug Targets, 8(1), 70 - 79.
    • Salama AD, Pusey CD (2009). Goodpasture's syndrome and other Anti-glomerular basement mebrane disease. In Greenberg A, Cheung AK (Ed.), Primer on kidney diseases (pp. - ). : W B Saunders Co.
    • Little MA, Hassan B, Jacques S, Game D, Salisbury E, Courtney AE, Brown C, Salama AD, Harper L (2009). Renal transplantation in systemic vasculitis: when is it safe?. Nephrol Dial Transplant, 24(10), 3219 - 3225. doi:10.1093/ndt/gfp347

    2008

    • Salama AD, Pusey CD (2008). Interstitial pulmonary and bronchiolar disorders. In Lynch JP (Ed.), Interstitial pulmonary and bronchiolar disorders (pp. - ). : Informa HealthCare.
    • Salama AD, Cook HT, Pusey CD, Pepper RJ (2008). A case of treated ANCA-associated vasculitis with recurrent renal failure.. Clin J Am Soc Nephrol, 3(2), 637 - 645. doi:10.2215/CJN.05071107
    • Salama AD, Sayegh MH (2008). Transplantation tolerance. In Brenner BM, Rector FC (Ed.), Brenner and Rector's the kidney (pp. - ). : W.B. Saunders Company.
    • Salama AD (2008). Critical care nephrology. In Ronco C, Bellomo R, Kellum JA (Ed.), Critical care nephrology (pp. - ). : W B Saunders Co.
    • Nouraei SA, Obholzer R, Ind PW, Salama AD, Pusey CD, Porter F, Howard DJ, Sandhu GS (2008). Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis.. Thorax, 63(1), 49 - 52. doi:10.1136/thx.2007.078915
    • Pepper RJ, Fabre MA, Pavesio C, Gaskin G, Jones RB, Jayne D, Pusey CD, Salama AD (2008). Rituximab is effective in the treatment of refractory Churg-Strauss syndrome and is associated with diminished T-cell interleukin-5 production.. Rheumatology (Oxford), 47(7), 1104 - 1105. doi:10.1093/rheumatology/ken175
    • Saw VP, Cornelius N, Salama AD, Pusey C, Lightman SL (2008). Infliximab therapy for aggressive mooren ulceration.. Arch Ophthalmol, 126(5), 734 - . doi:10.1001/archopht.126.5.734
    • Behmoaras J, Bhangal G, Smith J, McDonald K, Mutch B, Lai PC, Domin J, Game L, Salama A, Foxwell BM, Pusey CD, Cook HT, Aitman TJ (2008). Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.. Nat Genet, 40(5), 553 - 559. doi:10.1038/ng.137
    • Reynolds J, Tadros S, Smith J, Cook PR, Bhangal G, Salama AD, Aitman TJ, Cook HT, Pusey CD (2008). Genetic susceptibility to experimental autoimmune glomerulonephritis in congenic rats.

    2007

    • Reynolds J, Maine C, Sando GS, Salama AD, Pusey CD (2007). Transfer of tolerance to naive recipients by CD4+ and CD25+ T cells from donors with experimental autoimmune glomerulonephritis treated with an anti-ICOSL monoclonal antibody.
    • Salama A, Pusey C, Jayne D, Mosley K (2007). ABAVAS: A trial of CTLA4Ig in ANCA vasculitis.
    • Onions L, Brookes P, Mclean A, Taube D, Warrens A, Dorling A, Salama A (2007). Generation of regulatory T cells in renal transplant recipients following induction therapy with Campath-1H and Daclizumab.
    • Salama A, Ryba M, Levy J, Gaskin G, Pusey C (2007). Long-term outcome of patients with severe ANCA associated vasculitis treated with plasmapheresis.
    • Salama AD (2007). Pediatric solid organ transplantation. In Fine RN (Ed.), Pediatric solid organ transplantation (pp. - ). : Wiley-Blackwell.
    • Salama AD (2007). How high is the risk of ANCA-associated vasculitis recurring after renal transplantation?. Nat Clin Pract Nephrol, 3(10), 538 - 539. doi:10.1038/ncpneph0585
    • Salama AD, Womer KL, Sayegh MH (2007). Clinical transplantation tolerance: many rivers to cross.. J Immunol, 178(9), 5419 - 5423.
    • Reynolds J, Marsh OB, Sando GS, Salama AD, Pusey CD (2007). Manipulation of the PD1/PDL1 negative T cell costimulatory pathway in treatment of established experimental autoimmune glomerulonephritis.
    • Salama AD (2007). The kidney in systemic autoimmune diseases Renal Toxicities associated with immunomodulatory drugs. In Mason JC, Pusey CD (Ed.), The kidney in systemic autoimmune diseases (pp. - ). : Elsevier Science.

    2006

    • Hernandez-Fuentes MP, Salama A (2006). In vitro assays for immune monitoring in transplantation.. Methods Mol Biol, 333, 269 - 290. doi:10.1385/1-59745-049-9:269
    • Salama AD, Pusey CD (2006). Drug insight: rituximab in renal disease and transplantation.. Nat Clin Pract Nephrol, 2(4), 221 - 230. doi:10.1038/ncpneph0133

    2005

    • Patel A, Ind P, Pusey CD, Gaskin G, Salama A (2005). Outcomes of pulmonary renal syndrome in patients with ANCA associated vasculitis.
    • Salama AD (2005). Tipping the balance in glomerulonephritis.. J Am Soc Nephrol, 16(5), 1169 - 1171. doi:10.1681/ASN.2005030304
    • Salama AD, Sayegh MH (2005). Medical management of kidney transplantation. In Weir MR (Ed.), Medical management of kidney transplantation (pp. - ). : .
    • Yamada A, Salama AD, Sho M, Najafian N, Ito T, Forman JP, Kewalramani R, Sandner S, Harada H, Clarkson MR, Mandelbrot DA, Sharpe AH, Oshima H, Yagita H, Chalasani G, Lakkis FG, Auchincloss H, Sayegh MH (2005). CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.. J Immunol, 174(3), 1357 - 1364.
    • Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Yagita H, Turka LA, Sayegh MH (2005). Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection.. Am J Transplant, 5(1), 31 - 39. doi:10.1111/j.1600-6143.2004.00640.x
    • Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Domenig C, Habicht A, Najafian N, Yagita H, Azuma M, Turka LA, Sayegh MH (2005). Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo.. J Immunol, 174(6), 3408 - 3415.

    2004

    • Izawa A, Clarkson MR, Salama AD, Ueno T, Yagita H, Sharpe AH, Freeman GJ, Sayegh MH, Najafian N (2004). Generation of regulatory CD8(+) T cells by ICOS-B7h signal blockade in vivo..
    • Clarkson MR, Salama AD, Mueller T, Fernandes S, Harmon WE, Sayegh MH, Najafian N (2004). Regulatory phenotype is enriched in the CD25 'high' sub-population of CD4(+)CD25(+) cells expanded from renal transplant recipients..
    • Chitnis T, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ (2004). Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo.. J Immunol, 172(7), 4260 - 4265.
    • Yuan XL, Clarkson MR, Schmitt I, Salama AD, Auchincloss H, Glimcher LH, Sayegh MH (2004). T-bet deficient recipients exhibit a Th2 phenotype, develop accelerated acute and chronic humoral vascularized allograft rejection, and are resistant to immunosuppression and tolerance..
    • Reyal Y, Robinson C, Salama A, Levy JB (2004). Neurological complications from brachial arteriovenous fistulae.. Nephrol Dial Transplant, 19(7), 1923 - 1924. doi:10.1093/ndt/gfh290

    2003

    • Forman JP, Latchman YE, Salama AD, Blazar BR, Sharpe AH, Sayegh MH (2003). The role of B7 and CD2 family costimulatory molecules in natural killer cell function.
    • Yuan XL, Clarkson MR, Schmitt I, Salama AD, Auchincloss H, Glimcher LH, Sayegh MH (2003). The role of the novel gene, T-bet, in allograft rejection and tolerance..
    • Salama AD, Levy JB (2003). Tolerance and autoimmunity in anti-GBM disease.. J Am Soc Nephrol, 14(11), 2988 - 2989.
    • Salama AD, Yamada A, Forman J, Kewalramani R, Najafian N, Ito T, Sandner SE, Sho M, Harada H, Mandelbrot D, Sharpe AH, Oshima H, Chalasani G, Lakkis F, Yagita H, Auchincloss H, Sayegh MH (2003). CD70-CD27 is a critical CD28-independent costimulatory pathway for alloimmune CD8+T cell responses.
    • Clarkson MR, Salama AD, Mueller T, Sayegh MH, Najafian N (2003). Expansion and characterization of CD4(+)CD25(+) regulatory T-cells from human renal transplant recipients..
    • Najafian N, Sandner SE, Ito T, Kewalramani R, Salama AD, Yagita H, Azuma M, Auchincloss H, Turka LA, Sayegh MH (2003). Functions of the PD-1: PD-L1 costimulatory pathway in physiologic regulation of alloimmune responses in vivo.
    • Salama AD, Chaudhry AN, Holthaus KA, Mosley K, Kalluri R, Sayegh MH, Lechler RI, Pusey CD, Lightstone L (2003). Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease.. Kidney Int, 64(5), 1685 - 1694. doi:10.1046/j.1523-1755.2003.00259.x
    • Pusey CD, Harrington JT, Dasgupta I, Feehally J, Rees A, Hughes J, Singh A, Savage C, Salama A, Winearls C, Tomson C, Mathieson P, Oliveira D, Nelson W (2003). Anti-glomerular basement membrane disease. KIDNEY INT, 64(4), 1535 - 1550.
    • Sandner SE, Salama AD, Houser SL, Palmer E, Turka LA, Sayegh MH (2003). New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo.. Am J Transplant, 3(10), 1242 - 1250.
    • Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan XL, Clarkson MR, Sayegh MH, Khoury SJ (2003). Regulatory functions of CD8(+)CD28(-) T cells in an autoimmune disease model. J CLIN INVEST, 112(7), 1037 - 1048. doi:10.1172/JCI200317935
    • Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, Clarkson MR, Sayegh MH, Khoury SJ (2003). Regulatory functions of CD8+CD28- T cells in an autoimmune disease model.. J Clin Invest, 112(7), 1037 - 1048. doi:10.1172/JCI17935
    • Salama AD, Chitnis T, Imitola J, Ansari MJ, Akiba H, Tushima F, Azuma M, Yagita H, Sayegh MH, Khoury SJ (2003). Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis.. J Exp Med, 198(1), 71 - 78. doi:10.1084/jem.20022119
    • Ansari MJ, Salama AD, Chitnis T, Smith RN, Yagita H, Akiba H, Yamazaki T, Azuma M, Iwai H, Khoury SJ, Auchincloss H, Sayegh MH (2003). The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.. J Exp Med, 198(1), 63 - 69. doi:10.1084/jem.20022125
    • Harada H, Salama AD, Sho M, Izawa A, Sandner SE, Ito T, Akiba H, Yagita H, Sharpe AH, Freeman GJ, Sayegh MH (2003). The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. J CLIN INVEST, 112(2), 234 - 243. doi:10.1172/JCI200317008
    • Harada H, Salama AD, Sho M, Izawa A, Sandner SE, Ito T, Akiba H, Yagita H, Sharpe AH, Freeman GJ, Sayegh MH (2003). The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.. J Clin Invest, 112(2), 234 - 243. doi:10.1172/JCI17008
    • Salama AD, Najafian N, Clarkson MR, Harmon WE, Sayegh MH (2003). Regulatory CD25+ T cells in human kidney transplant recipients.. J Am Soc Nephrol, 14(6), 1643 - 1651.
    • Salama AD, Sayegh MH (2003). Alternative T-cell costimulatory pathways in transplant rejection and tolerance induction: hierarchy or redundancy?. Am J Transplant, 3(5), 509 - 511.
    • Salama AD, Yuan X, Nayer A, Chandraker A, Inobe M, Uede T, Sayegh MH (2003). Interaction between ICOS-B7RP1 and B7-CD28 costimulatory pathways in alloimmune responses in vivo.. Am J Transplant, 3(4), 390 - 395.
    • Yuan X, Salama AD, Dong V, Schmitt I, Najafian N, Chandraker A, Akiba H, Yagita H, Sayegh MH (2003). The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo.. J Immunol, 170(6), 2949 - 2955.

    2002

    • Salama AD, Pusey CD (2002). Immunology of anti-glomerular basement membrane disease.. Curr Opin Nephrol Hypertens, 11(3), 279 - 286.
    • Najafian N, Salama AD, Harmon WE, Sayegh MH (2002). The role of CD25+regulatory T cells as modulators of the indirect alloimmune response in stable human renal transplant recipients..
    • Dougan T, Levy JB, Salama A, George AJ, Pusey CD (2002). Characterization of autoantibodies from patients with Goodpasture's disease using a resonant mirror biosensor.. Clin Exp Immunol, 128(3), 555 - 561.
    • Salama AD, Sayegh MH (2002). Challenges for the translation of T cell costimulatory blockade therapies to the clinic.. Expert Opin Biol Ther, 2(5), 453 - 457. doi:10.1517/14712598.2.5.453
    • Yuan X, Dong VM, Coito AJ, Waaga AM, Salama AD, Benjamin CD, Sayegh MH, Chandraker A (2002). A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection.. Transplantation, 73(11), 1736 - 1742.
    • Zhai Y, Shen XD, Gao F, Coito AJ, Wasowska BA, Salama A, Schmitt I, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW (2002). The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation.. J Immunol, 169(3), 1270 - 1276.
    • Yuan X, Dong VM, Coito AJ, Waaga A, Salama AD, Benjamin CD, Sayegh MH, Chandraker A (2002). Effects of CD40/CD154 blockade on allograft rejection.
    • Najafian N, Salama AD, Fedoseyeva EV, Benichou G, Sayegh MH (2002). Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients.. J Am Soc Nephrol, 13(1), 252 - 259.
    • Yamada A, Salama AD, Sayegh MH (2002). The role of novel T cell costimulatory pathways in autoimmunity and transplantation.. J Am Soc Nephrol, 13(2), 559 - 575.
    • Salama AD (2002). Acute renal failure in practice. In Glynne P, Allen A, Pusey C (Ed.), Acute renal failure in practice (pp. - ). : Imperial College Pr.
    • Chitnis T, Benou C, Najafian N, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ (2002). Blockade of T-cell costimulatory pathways protects from experimental autoimmune encephalomyelitis in Th2 deficient mice.
    • Sho M, Sandner SE, Najafian N, Salama AD, Dong V, Yamada A, Kishimoto K, Harada H, Schmitt I, Sayegh MH (2002). New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.. Ann Surg, 236(5), 667 - 675. doi:10.1097/01.SLA.0000033322.80911.17
    • Sho M, Yamada A, Najafian N, Salama AD, Harada H, Sandner SE, Sanchez-Fueyo A, Zheng XX, Strom TB, Sayegh MH (2002). Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size.. J Immunol, 169(7), 3744 - 3751.
    • Sayegh MH, Sandner S, Salama A, Langmuir P, Palmer E, Turka LA (2002). A novel transgenic model for tracking alloreactive CD4+T cell responses and investigating the mechanisms of tolerance in vivo..
    • Salama AD, Yuan XL, Uede T, Chandraker A, Sayegh MH (2002). Interactions between the ICOS-B7H and the CD28-B7 costimulatory pathways in regulating alloimmune responses in vivo..
    • Ansari MJI, Salama AD, Auchincloss H, Sayegh MH (2002). Regulation of autoimmune diabetes in NOD mice: Critical role for the PD-1 : PD-L1 costimulatory pathway..
    • Salama AD, Chaudhry A, Sayegh MH, Lechler RI, Pusey CD, Lightstone L (2002). The role of CD25+regulatory cells in restoring tolerance in autoimmune anti-GBM (Goodpasture's) disease..
    • Salama AD, Dougan T, Levy JB, Cook HT, Morgan SH, Naudeer S, Maidment G, George AJ, Evans D, Lightstone L, Pusey CD (2002). Goodpasture's disease in the absence of circulating anti-glomerular basement membrane antibodies as detected by standard techniques.. Am J Kidney Dis, 39(6), 1162 - 1167. doi:10.1053/ajkd.2002.33385

    2001

    • Salama AD, Sayegh MH (2001). Achieving clinical transplant tolerance: What are the hurdles?.
    • Salama AD, Delikouras A, Pusey CD, Cook HT, Bhangal G, Lechler RI, Dorling A (2001). Transplant accommodation in highly sensitized patients: a potential role for Bcl-xL and alloantibody.. Am J Transplant, 1(3), 260 - 269.
    • Salama AD, Pusey CD (2001). Rheumatology and the kidney Tubulointerstitial nephritis. In Adu D, Emery P, Madaio MP (Ed.), Rheumatology and the kidney (pp. - ). : Oxford University Press, USA.
    • Yamada A, Kishimoto K, Dong VM, Sho M, Salama AD, Anosova NG, Benichou G, Mandelbrot DA, Sharpe AH, Turka LA, Auchincloss H, Sayegh MH (2001). CD28-independent costimulation of T cells in alloimmune responses.. J Immunol, 167(1), 140 - 146.
    • Salama AD, Levy JB, Lightstone L, Pusey CD (2001). Goodpasture's disease.. Lancet, 358(9285), 917 - 920. doi:10.1016/S0140-6736(01)06077-9
    • Salama AD, Remuzzi G, Harmon WE, Sayegh MH (2001). Challenges to achieving clinical transplantation tolerance.. J Clin Invest, 108(7), 943 - 948. doi:10.1172/JCI14142
    • Chitnis T, Najafian N, Benou C, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ (2001). Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.. J Clin Invest, 108(5), 739 - 747. doi:10.1172/JCI12563
    • Salama AD, Chaudhry AN, Ryan JJ, Eren E, Levy JB, Pusey CD, Lightstone L, Lechler RI (2001). In Goodpasture's disease, CD4(+) T cells escape thymic deletion and are reactive with the autoantigen alpha3(IV)NC1.. J Am Soc Nephrol, 12(9), 1908 - 1915.
    • Yamada A, Salama AD, Najafian N, Auchincloss H, Sayegh MH (2001). TNF:TNF-R T-Cell costimulatory pathways in transplantation.. Transplant Proc, 33(7-8), 3070 - 3071.
    • Sho M, Salama AD, Yamada A, Najafian N, Sayegh MH (2001). Physiologic regulation of alloimmune responses in vivo: the role of CTLA4 and TH1/TH2 cytokines.. Transplant Proc, 33(7-8), 3826 - 3828.

    1999

    • Salama A, Dorling A, Hayes M, Bhangal G, Delikouras A, Malde P, Cook T, Pusev C, Lechler R (1999). Transplant accommodation is associated with up-regulation or anti-apoptotic proteins: In vitro models implicate iNOS induction by low levels or anti-donor antibody in accommodated endothelial cells.
    • Glynne P, Salama A, Chaudhry A, Swirsky D, Lightstone L (1999). Quinine-induced immune thrombocytopenic purpura followed by hemolytic uremic syndrome.. Am J Kidney Dis, 33(1), 133 - 137.
    • Warrens AN, Waters JB, Salama AD, Lechler RI (1999). Improving the therapeutic monitoring of cyclosporin A.. Clin Transplant, 13(2), 193 - 200.
    • Baker RJ, Salama AD, Chaudhry AN, Cook HT, Pusey CD (1999). Acute tubulointerstitial nephritis - a clinicopathological study of 22 patients..
    • Salama AD (1999). Pathogenesis and treatment of ANCA-associated systemic vasculitis.. J R Soc Med, 92(9), 456 - 461.

    1998

    • Salama A (1998). Treatment of renal angiomyolipoma - Reply. NEW ENGL J MED, 339(19), 1400 - 1400.
    • Salama AD, Pusey CD (1998). Images in clinical medicine. Tuberous sclerosis.. N Engl J Med, 338(26), 1886 - . doi:10.1056/NEJM199806253382605

    1997

    • Lightstone L, Salama A, Malik A, Fullwood Y (1997). Resident renal cell populations may be able to function as antigen presenting cells to CD4+ T cells..
    • Lightstone L, Glynne P, Salama A (1997). Quinine-dependent anti-glycoprotein antibodies causing thrombocytopenia and hemolytic uremic syndrome (HUS)..
    • Salama AD, Rogers T, Lord GM, Lechler RI, Mason PD (1997). Multiple Cladosporium brain abscesses in a renal transplant patient: aggressive management improves outcome.. Transplantation, 63(1), 160 - 162.

    1996

    • Warrens AN, Salama A, Waters JB, Lechler RI (1996). Comparison of Neoral and Sandimmune preparations in renal transplant patients--improved pharmacokinetics with neoral.. Transplant Proc, 28(4), 2169 - 2170.

    • Derrett-Smith EC (). Revisiting ANCA-associated vasculitis in systemic sclerosis: clinical, serological and immunogenetic factors. Rheumatology, , - . doi:10.1093/rheumatology/ket213
    • Todd SK (). B regulatory cells are numerically but not functionally impaired in AAV. doi:10.1016/j.lpm.2013.02.019
    • Salama AD, Henderson SR (). Haemorrhage and thrombosis: tackling two sides of a single vasculitic disease.. Nephrology Dialysis Transplantation, 2012 Aug 16 EPub, - .