Dr Gyorgy Szabadkai


Personal Profile

Name: Gyorgy Szabadkai Email: g.szabadkai@ucl.ac.uk
Title: Dr Tel: +44 (0)2076797362
Department: Cell & Developmental Biology Fax: +44 (0)2079167968
Position: Senior Lecturer Address: Gower Street, , London, WC1E 6BT
Research Domain: Basic Life Sciences, Biomedical Imaging (Frontier Disciplines), Cancer, Cardiometabolic Science, Computational Science & Digital Systems, Neuroscience, Personalised Medicine Web Page: Personal Web Page


Research Description

The overarching aim of my research group is to understand how transcriptional and translational regulation of the mitochondrial proteome (termed as mitochondrial biogenesis) is converted into bioenergetic and signaling responses of the organelle. In particular, we focus on how coordinatedregulation of mitochondrial biogenesis provides adaptation to mitochondrial stress in primary and secondary mitochondrial disease. We aim to use unbiased approaches to identify components of adaptive mitochondrial biogenesis pathways which will represent therapeutic targets to develop novel treatment strategies.

Ongoing projects in my laboratory have characterised a series of adaptive mechanisms covering the function of the PGC-1 family of transcriptional co-regulators and the neuroprotective redox chaperone DJ-1 under protein unfolding and genotoxic stress conditions. In addition, we have developed novel computational approaches to analyse exome sequencing, transcriptome and proteome data focusing on genes covering the mitochondrial proteome. Using these approaches we identified novel transcriptional networks regulating mitochondrial biogenesis in response to cellular stress accompanying major pathologies, such as neurodegenerative disease, cardiomyopathies and cancer. Finally, we demonstrated the pathological role of mitochondrial Ca2+ overload in human disease. Accordingly, we have developed, validated and applied screening strategies to identify chemical compounds targeting mitochondrial Ca2+ signalling pathways to prevent Ca2+ mediated pathologies.    


Research Activities

Cellular Stress and Mitochondria

Mitochondrial dysfunction

Molecular mechanisms of cisplatin resistance

Molecular pathology and genetics of ovarian cancer

The mitochondrial permeability transition pore

The role of mitochondria in cardioprotection

Education Description

UCL Collaborators

Dr Sean Davidson; Prof James Moon; Prof David Selwood; Prof Martin Crompton; Prof Derek Hausenloy; Prof Michael Duchen; Prof Shamima Rahman; Prof Tony Schapira; Prof Stephen Moss; Prof Mark Lythgoe; Dr Ilias Tachtsidis

External Collaborators



    • Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.. Cell Death Differ, 22(1), 58 - 73. doi:10.1038/cdd.2014.137


    • Bain AJ (2014). Separating NADH and NADPH fluorescence in live cells and tissues using FLIM. Nature Communications, 5, - . doi:10.1038/ncomms4936
    • Logan CV, Sharpe JA, De Stefani D, Raffaello A, Rizzuto R, Duchen MR, Muntoni F, Sheridan E, Szabadkai G (2014). Genetic defects in mitochondrial calcium handling cause neuromuscular disease. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 47 - 47.
    • Dongworth RK, Mukherjee UA, Hall AR, Astin R, Ong SB, Yao Z, Dyson A, Szabadkai G, Davidson SM, Yellon DM, Hausenloy DJ (2014). DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury.. Cell Death Dis, 5, e1082 - . doi:10.1038/cddis.2014.41
    • Tufo G, Jones AW, Wang Z, Hamelin J, Tajeddine N, Esposti DD, Martel C, Boursier C, Gallerne C, Migdal C, Lemaire C, Szabadkai G, Lemoine A, Kroemer G, Brenner C (2014). The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.. Cell Death Differ, 21(5), 685 - 695. doi:10.1038/cdd.2013.193
    • Montague K, Malik B, Gray AL, La Spada AR, Hanna MG, Szabadkai G, Greensmith L (2014). Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy.. Brain, 137(Pt 7), 1894 - 1906. doi:10.1093/brain/awu114
    • Hill JM, De Stefani D, Jones AW, Ruiz A, Rizzuto R, Szabadkai G (2014). Measuring baseline Ca(2+) levels in subcellular compartments using genetically engineered fluorescent indicators.. Methods Enzymol, 543, 47 - 72. doi:10.1016/B978-0-12-801329-8.00003-9
    • Chinopoulos C, Szabadkai G (2014). What Makes You Can also Break You, Part III: Mitochondrial Permeability Transition Pore Formation by an Uncoupling Channel within the C-Subunit Ring of the F1FO ATP Synthase?. Front Oncol, 4, 235 - . doi:10.3389/fonc.2014.00235
    • Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R, UK10K Consortium , Duchen MR, Muntoni F, Sheridan E (2014). Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.. Nat Genet, 46(2), 188 - 193. doi:10.1038/ng.2851
    • Dalton CM, Szabadkai G, Carroll J (2014). Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption.. J Cell Physiol, 229(3), 353 - 361. doi:10.1002/jcp.24457
    • Galluzzi L, Vitale I, Michels J, Brenner C, Szabadkai G, Harel-Bellan A, Castedo M, Kroemer G (2014). Systems biology of cisplatin resistance: past, present and future.. Cell Death Dis, 5, e1257 - . doi:10.1038/cddis.2013.428
    • Childs AM, Pysden K, Roper H, Chow G, Niks EH, Kriek M, Chinnery PF, Lewis-Smith D, Duchen M, Szabadkai G, Logan C, Sheridan E, Sewry C, Muntoni F (2014). Clinical and pathological features associated with mutations in MICU1. doi:10.1016/j.nmd.2014.06.187


    • Wojtala A, Lebiedzinska M, Karkucinska-Wieckowska A, Szabadkai G, Duszynski J, Wieckowski MR (2013). The role of reactive oxygen species in the pathogenesis of mitochondrial disorders. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 43, 46 - 46.
    • Chinopoulos C, Szabadkai G (2013). What makes you can also break you: mitochondrial permeability transition pore formation by the c subunit of the F(1)F(0) ATP-synthase?. Front Oncol, 3, 25 - . doi:10.3389/fonc.2013.00025
    • Lebiedzinska M, Karkucinska-Wieckowska A, Wojtala A, Suski JM, Szabadkai G, Wilczynski G, Wlodarczyk J, Diogo CV, Oliveira PJ, Tauber J, Ježek P, Pronicki M, Duszynski J, Pinton P, Wieckowski MR (2013). Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients.. Int J Biochem Cell Biol, 45(1), 141 - 150. doi:10.1016/j.biocel.2012.07.020
    • Szabadkai G, Chinopoulos C (2013). What Makes You Can Also Break You, Part II: Mitochondrial Permeability Transition Pore Formation by Dimers of the F1FO ATP-Synthase?. Front Oncol, 3, 140 - . doi:10.3389/fonc.2013.00140
    • Botta A, Malena A, Loro E, Del Moro G, Suman M, Pantic B, Szabadkai G, Vergani L (2013). Altered Ca2+ homeostasis and endoplasmic reticulum stress in myotonic dystrophy type 1 muscle cells.. Genes (Basel), 4(2), 275 - 292. doi:10.3390/genes4020275
    • Szabadkai G, Rizzuto R (2013). Kαλóς και Aγαθóς: how mitochondrial beauty translates into biological virtue.. Curr Opin Cell Biol, 25(4), 477 - 482. doi:10.1016/j.ceb.2013.03.006
    • Ibarra C, Vicencio JM, Estrada M, Lin Y, Rocco P, Rebellato P, Munoz JP, Garcia-Prieto J, Quest AF, Chiong M, Davidson SM, Bulatovic I, Grinnemo KH, Larsson O, Szabadkai G, Uhlén P, Jaimovich E, Lavandero S (2013). Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors.. Circ Res, 112(2), 236 - 245. doi:10.1161/CIRCRESAHA.112.273839
    • Astin R, Bentham R, Djafarzadeh S, Horscroft JA, Kuc RE, Leung PS, Skipworth JR, Vicencio JM, Davenport AP, Murray AJ, Takala J, Jakob SM, Montgomery H, Szabadkai G (2013). No evidence for a local renin-angiotensin system in liver mitochondria.. Sci Rep, 3, 2467 - . doi:10.1038/srep02467


    • Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J (2012). SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering.. Cell Death Differ, 19(4), 650 - 660. doi:10.1038/cdd.2011.139
    • Yao Z, Jones AW, Szabadkai G (2012). Mitochondrion-nucleus retrograde signaling mediates survival of cancer cells. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 42, 73 - 73.
    • Klionsky DJ, Backues SK, Bartholomew CR, Bridges D, Gestwicki JE, Han T, Jin M, Kim JK, Lin JD, Lynch-Day MA, Mao K, Nair U, Parzych KR, Umekawa M, Wang K, Yen W-L, Zhao M, Olsen LJ, Abdalla FC, Marcondes M, Silva-Zacarin ECM, Silva-Zacarin E, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Chiarelli R, Roccheri MC, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Saitoh T, Al-Younes HM, Al-Zeer MA, Meyer TF, Albert ML, Albin RL, Dowling JJ, Alegre-Abarrategui J, Wade-Martins R, Aleo MF, Fanzani A, Rovetta F, Alirezaei M, Chisari FV, Whitton JL, Almasan A, Almonte-Becerril M, Kouri Flores JB, Amano A, Amaravadi R, Amarnath S, Fowler DH, Amer AO, Drew ME, Andrieu-Abadie N, Poirot M, Vindis C, Anantharam V, Kanthasamy AG, Kanthasamy A, Ann DK, Anoopkumar-Dukie S, Grant GD, Aoki H, Apostolova N, Arancia G, Condello M, Meschini S, Aris JP, Asanuma K, Tomino Y, Asare NYO, Ashida H, Askanas V, Nogalska A, Askew DS, Auberger P, Bost F, Gual P, Luciano F, Rocchi S, Baba M, Baehrecke EH, Bahr BA, Bai X-Y, Chen X, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Brunetti-Pierri N, Settembre C, Bamber BA, Bampton ETW, Melino G, Bánhegyi G, Bassham DC, Bast Jr RC, Fan Z, Lopez-Berestein G, Lu Z, Ozpolat B, Batoko H, Bay B-H, Beau I, Esclatine A, Béchet DM, Begley TJ, Behl C, Behrends C, Dikic I, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Sanchez AMJ, Bernassola F, Marfe G, Palumbo C, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Espert L, Blum JS, Boise LH, Lonial S, Sun S-Y, Bonaldo P, Sandri M, Boone DL, Bornhauser BC, Bourquin J-P, Bortoluci KR, Bossis I, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Nezis IP, Rusten TE, Stenmark H, Brenman JE, Brennand A, Michels PAM, Bresnick EH, Kang Y-A, Brest P, Hofman P, Mograbi B, Bristol ML, Gewirtz DA, Brookes PS, Johnson GVW, Brown EJ, Brumell JH, Huang J, Kim PK, Brunk UT, Kurz T, Bulman DE, Bultman SJ, Bultynck G, Parys JB, Burbulla LF, Krüger R, Bursch W, Butchar JP, Buzgariu W, Galliot B, Bydlowski SP, Cadwell K, Cahová M, Papackova Z, Cai D, Cai J, Cai Q, Calabretta B, Sotgia F, Calvo-Garrido J, Escalante R, Camougrand N, Manon S, Priault M, Campanella M, Campos-Salinas J, Gonzalez-Rey E, Oliver FJ, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Moreira PI, Carew JS, Nawrocki ST, Carlin CR, Carmignac V, Durbeej M, Carneiro LAM, Carra S, Kampinga HH, Caruso RA, Casari G, Casas C, Castino R, Isidoro C, Cebollero E, Reggiori F, Cecconi F, Ciriolo MR, Piacentini M, Celli J, Chaachouay H, Rodemann HP, Chae H-J, Chai C-Y, Chan DC, Chan EY, Coombs GH, Chang RC-C, Che C-M, Lok C-N, Sy L-K, Chen C-C, Lin W-W, Chen G-C, Yang WY, Chen G-Q, Chen M, Wang J, Chen Q, Chen SS-L, Ke P-Y, Lin Y-L, Chen W, Chen Y-G, Liu Y, Yu L, Chen Y, Guan J-L, Towns R, Wiley JW, Chen Y-J, Chen Z, Cheng A, Cheng CHK, Cheng Y, Wang H-G, Yang J-M, El-Deiry WS, Cheong H, Thompson CB, Cheong J-H, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang H-L, Chiba T, Chin L-S, Li L, Mao Z, Chiou S-H, Cho CH, Cho D-H, Choi AMK, Haspel JA, Henske EP, Nakahira K, Ryter SW, Choi D, Choi KS, Choi ME, Münger K, Chouaib S, Choubey D, Choubey V, Kaasik A, Chu CT, Rabinowich H, Chuang T-H, Chueh S-H, Chun T, Park OK, Chwae Y-J, Chye M-L, Ciarcia R, Florio S, Granato GE, Clague MJ, Clark RSB, Clarke PGH, Puyal J, Clarke R, Saha T, Codogno P, Coller HA, Colombo MI, Comincini S, Condorelli F, Cookson MR, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Helfrich MH, Hocking LJ, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Kaushik S, Koga H, Czaja MJ, Cullen JJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, De Groot JF, Fueyo J, Gomez-Manzano C, Jiang H, De Haan CAM, Monastyrska I, De M (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445 - 544. doi:10.4161/auto.19496
    • Yao Z, Szabadkai G (2012). Transcriptional profiling of apoptosis: cell death classification moves toward the systems era.. Cell Cycle, 11(20), 3721 - 3722. doi:10.4161/cc.22116
    • Jones AW, Yao Z, Vicencio JM, Karkucinska-Wieckowska A, Szabadkai G (2012). PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling.. Mitochondrion, 12(1), 86 - 99. doi:10.1016/j.mito.2011.09.009
    • Lebiedzinska M, Karkucinska-Wieckowska A, Suski JM, Szabadkai G, Diogo CV, Wilczynski G, Wlodarczyk J, Pronicki M, Duszynski J, Oliviera P, Pinton P, Wieckowski MR (2012). Oxidative stress induced p66Shc phosphorylation in fibroblasts with neuropathy, ataxia and retinitis pigmentosa (NARP) syndrome. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 42, 70 - 70.
    • Yao Z, Jones AW, Fassone E, Sweeney MG, Lebiedzinska M, Suski JM, Wieckowski MR, Tajeddine N, Hargreaves IP, Yasukawa T, Tufo G, Brenner C, Kroemer G, Rahman S, Szabadkai G (2012). PGC-1beta mediates adaptive chemoresistance associated with mitochondrial DNA mutations. Oncogene, , - . doi:10.1038/onc.2012.259


    • Suski JM, Karkucinska-Wieckowska A, Lebiedzinska M, Giorgi C, Szczepanowska J, Szabadkai G, Duszynski J, Pronicki M, Pinton P, Wieckowski MR (2011). p66Shc Aging Protein in Control of Fibroblasts Cell Fate. INT J MOL SCI, 12(8), 5373 - 5389. doi:10.3390/ijms12085373
    • Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S (2011). Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.. J Cell Sci, 124(Pt 13), 2143 - 2152. doi:10.1242/jcs.080762
    • Vicencio JM, Estrada M, Galvis D, Bravo R, Contreras AE, Rotter D, Szabadkai G, Hill JA, Rothermel BA, Jaimovich E, Lavandero S (2011). Anabolic androgenic steroids and intracellular calcium signaling: a mini review on mechanisms and physiological implications.. Mini Rev Med Chem, 11(5), 390 - 398.
    • Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S (2011). Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress (vol 124, pg 2143, 2011). J CELL SCI, 124(14), 2511 - 2511. doi:10.1242/jcs.095455
    • Skipworth JR, Szabadkai G, Olde Damink SW, Leung PS, Humphries SE, Montgomery HE (2011). Review article: pancreatic renin-angiotensin systems in health and disease.. Aliment Pharmacol Ther, 34(8), 840 - 852. doi:10.1111/j.1365-2036.2011.04810.x


    • Duchen MR, Szabadkai G (2010). Roles of mitochondria in human disease.. Essays Biochem, 47, 115 - 137. doi:10.1042/bse0470115
    • Vicencio JM, Lavandero S, Szabadkai G (2010). Ca2+, autophagy and protein degradation: thrown off balance in neurodegenerative disease.. Cell Calcium, 47(2), 112 - 121. doi:10.1016/j.ceca.2009.12.013
    • Ruhanen H, Borrie S, Szabadkai G, Tyynismaa H, Jones AWE, Kang D, Taanman J-W, Yasukawa T (2010). Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organization.. Biochim Biophys Acta., 1803(8), 931 - 939. doi:10.1016/j.bbamcr.2010.04.008
    • Jones AW, Szabadkai G (2010). Ca²(+) transfer from the ER to mitochondria: channeling cell death by a tumor suppressor.. Dev Cell, 19(6), 789 - 790. doi:10.1016/j.devcel.2010.11.013


    • Szabadkai G, Duchen MR (2009). Mitochondria mediated cell death in diabetes.. Apoptosis, , - . doi:10.1007/s10495-009-0363-5
    • Vicencio JM, Ortiz C, Criollo A, Jones AW, Kepp O, Galluzzi L, Joza N, Vitale I, Morselli E, Tailler M, Castedo M, Maiuri MC, Molgó J, Szabadkai G, Lavandero S, Kroemer G (2009). The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.. Cell Death Differ, 16(7), 1006 - 1017. doi:10.1038/cdd.2009.34
    • Lebiedzinska M, Szabadkai G, Jones AW, Duszynski J, Wieckowski MR (2009). Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles.. Int J Biochem Cell Biol, 41(10), 1805 - 1816. doi:10.1016/j.biocel.2009.02.017
    • Kozieł K, Lebiedzinska M, Szabadkai G, Onopiuk M, Brutkowski W, Wierzbicka K, Wilczyński G, Pinton P, Duszyński J, Zabłocki K, Wieckowski MR (2009). Plasma membrane associated membranes (PAM) from Jurkat cells contain STIM1 protein is PAM involved in the capacitative calcium entry?. Int J Biochem Cell Biol, 41(12), 2440 - 2449. doi:10.1016/j.biocel.2009.07.003


    • Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G (2008). Regulation of autophagy by cytoplasmic p53. Nature Cell Biology, , - .
    • Szabadkai G, Duchen MR (2008). Mitochondria: the hub of cellular Ca2+ signaling.. Physiology (Bethesda), 23(2), 84 - 94.
    • Aguiari G, Trimi V, Bogo M, Mangolini A, Szabadkai G, Pinton P, Witzgall R, Harris PC, Borea PA, Rizzuto R, del Senno L (2008). Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells.. Cell Prolif, 41(3), 554 - 573. doi:10.1111/j.1365-2184.2008.00529.x
    • Bolshakov AP, Mikhailova MM, Szabadkai G, Pinelis VG, Brustovetsky N, Rizzuto R, Khodorov BI (2008). Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation.. Cell Calcium, 43(6), 602 - 614. doi:10.1016/j.ceca.2007.10.005
    • Szabadkai G, Duchen MR (2008). Mitochondria: The hub of cellular Ca2+ signaling (vol 23, pg 84, 2008). PHYSIOLOGY, 23(4), 230 - 230. doi:10.1152/physiol.00101.2008
    • Leo S, Szabadkai G, Rizzuto R (2008). The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2+) load upon cell stimulation by inhibiting Ca(2+) efflux from the organelle.. Ann N Y Acad Sci, 1147, 264 - 274. doi:10.1196/annals.1427.019
    • Campanella M, Szabadkai G, Rizzuto R (2008). Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195.. Biochem Pharmacol, 76(11), 1628 - 1636. doi:10.1016/j.bcp.2008.09.034
    • Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini-Bréchot P (2008). Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress.. Mol Cell, 32(5), 641 - 651. doi:10.1016/j.molcel.2008.11.014
    • Saotome M, Safiulina D, Szabadkai G, Das S, Fransson A, Aspenstrom P, Rizzuto R, Hajnóczky G (2008). Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.. Proc Natl Acad Sci U S A, 105(52), 20728 - 20733. doi:10.1073/pnas.0808953105
    • Tufi R, Panaretakis T, Bianchi K, Criollo A, Fazi B, Di Sano F, Tesniere A, Kepp O, Paterlini-Brechot P, Zitvogel L, Piacentini M, Szabadkai G, Kroemer G (2008). Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin. Cell Death and Differentiation, 15(2), 274 - 282.


    • Szabadkai G, Simoni AM, Bianchi K, De Stefani D, Leo S, Wieckowski MR, Rizzuto R (2006). Mitochondrial dynamics and Ca2+ signaling. BBA-MOL CELL RES, 1763(5-6), 442 - 449. doi:10.1016/j.bbamer.2006.04.002


    • Rizzuto R, Pinton P, Rapizzi E, Vandecastecle G, Szabadkai G (2002). Mitochondrial Ca2+ signalling: Molecular determinants and physiological role. BIOPHYS J, 82(1), 1A - 1A.


    • Rizzuto R, Rapizzi P, Pinton E, Vandecasteele G, Szabadkai G (2001). Recombinant probes in the study of cell signalling. J NEUROCHEM, 78, 111 - 111.


    • Spät A, Pitter J, Rohács T, Szabadkai G (2000). Calcium signal and mitochondrial metabolism in steroid producing cells.. Endocr Res, 26(4), 615 - 616.
    • Szabadkai G, Pitter JG, Spat A (2000). Mitochondrial Ca2+ concentration and NAD(P)H formation in rat luteal cells. FASEB J, 14(4), A578 - A578.
    • Szabadkai G, Pitter JG, Spat A (2000). Effect of extramitochondrial Ca2+ on mitochondrial matrix Ca2+ concentration. J PHYSIOL-LONDON, 526, 6P - 6P.


    • Szabadkai G, Várnai P, Enyedi P (1999). Selective inhibition of potassium-stimulated rat adrenal glomerulosa cells by ruthenium red.. Biochem Pharmacol, 57(2), 209 - 218.


    • Szabadkai G, Horváth A, Spat A, Enyedi P (1998). Expression of voltage-dependent calcium channel alpha1 subunits in rat adrenal capsular tissue and single glomerulosa cells.. Endocr Res, 24(3-4), 425 - 426.
    • Horváth A, Szabadkai G, Várnai P, Arányi T, Wollheim CB, Spät A, Enyedi P (1998). Voltage dependent calcium channels in adrenal glomerulosa cells and in insulin producing cells.. Cell Calcium, 23(1), 33 - 42.


    • Enyedi P, Szabadkai G, Varnai P, Spat A (1997). Calcium influx routes in the stimulated rat adrenal glomerulosa cells. N-S ARCH PHARMACOL, 356(4), 103 - 103.


    • Spät A, Rohács T, Horváth A, Szabadkai G, Enyedi P (1996). The role of voltage-dependent calcium channels in angiotensin-stimulated glomerulosa cells.. Endocr Res, 22(4), 569 - 576.
    • Szabadkai G, Horváth A, Rohács T, Vimláti L, Spät A, Enyedi P (1996). Expression of inositol 1,4,5-trisphosphate receptors in rat adrenocortical zones.. J Steroid Biochem Mol Biol, 57(1-2), 13 - 17.


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