Prof Lucy Wedderburn

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Personal Profile

Name: Lucy Wedderburn Email: l.wedderburn@ucl.ac.uk
Title: Prof Tel:
Department: ICH Infect, Imm, Infla. & Physio Med Fax:
Position: Professor of Paediatric Rheumatology Address: Institute of Child Health 30 Guilford Street, , London, WC1N1EH
Research Domain: Infection, Immunology & Inflammation, Neuroscience, Personalised Medicine, Populations & Lifelong Health Web Page:  

Profile

Research Description

My research interests are T cell immunology, immune regulation and muscle biology. My lab group has a major focus upon human T cell responses and immune regulation, in particular the autoimmune conditions of childhood, including Juvenile Idiopathic Arthritis (JIA) and Juvenile Dermatomyositis (JDM). We are interested in the mechanisms which allow survival and expansion of inflammatory T cells within the joint, the control of their production of cytokines and chemokines, and their contribution to disease. In tandem we study immune regulation and how this influences disease course and phenotype in JIA . 

I am also Director of the Arthritis Research UK Centre for Adolescent Rheumatology, a partnership between ICH, UCL (Medicine), GOSH and UCLH which aims to promote and develop research in Adolescent Rheumatology. 

Childhood arthritis has proved an excellent model in which to study the balance between activation and regulation in the immune system. We have shown that highly proinflammatory cells, Th17 cells, are more abundant in patients with mild forms of arthritis than those with the more severe disease type, and that Treg and Th17 cells exist in a reciprocal relationship in the joint. We have generated evidence for 'plasticity' of Th17 cells at the inflamed site. More recently we have identified a novel set of regulatory cells, defined by expression of CD161 that are also pro inflammatory. 

 These data led to our study to reveal mechanistic differences between two clinical groups of patients, known as persistent and extended oligoarticular JIA. We have found biological differences of gene expression, cell frequency and phenotype between these two disease courses, which pre date the clinical severity phenotype. The group leads a major study, CHARMS (Childhood Arthritis Response to Medication Study) which aims to define the factors which influence the response of children with JIA to the drugs methotrexate (MTX) or anti tumour necrosis factor (TNF). This interdisciplinary study has generated genetic, psychological and immunological data linked to carefully defined clinical response phenotypes, to understand the mechanisms of response to MTX, or the reasons for a failure of efficacy of MTX in JIA.  We have just completed a genome wide association study ( GWAS) of response to MTX in JIA. 

We also have a major interest in the pathology of muscle damage in childhood inflammatory myositis. This work is closely linked to our work through the Juvenile Dermatomyositis (JDM) Cohort and Biomarker Study and the Juvenile Dermatomyositis Research Centre see http://www.ucl.ac.uk/ich/research-ich/rheumatology-unit/research

Our recent projects have included biology of muscle stem cells (satellite cells), novel autoantibodies in JDM and an analysis of the role of MRP/S100 proteins in childhood myositis.


Research Activities

Gene expression profiling/genomics

Immunopathogenesis of paediatric autoimmune diseas

Inflammatory conditions of the gastrointestinal tract

JDM vasculopathy

JIA genetics

Lentiviral vector delivery of immune modulatory molecules

Muscle stem cell work

RANK/RANKL study

Response to MTX in JIA

characterisation of the genetic and immunological

Education Description

UCL Collaborators

Prof Adrian Thrasher; Prof Patricia Woo; Prof John Hardy; Dr Mike Hubank; Prof Andrew Lees; Prof David Isenberg; Prof Stan Newman; Prof Kailash Bhatia; Dr Paul Brogan; Prof Nicholas Luscombe; Prof Martin Rossor; Dr Mona Bajaj-Elliot; Dr Babis Rallis; Prof Steve Humphries; Prof Nick Fox

External Collaborators

Publications

    2014

    • Verstappen SM, Cobb J, Foster HE, Fu B, Baildam E, Wedderburn LR, Davidson JE, Ioannou J, Chieng A, Hyrich KL, Thomson W (2014). Low socio-economic status is associated with high physical limitations and low illness self-perception in patients with juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS).. Arthritis Care Res (Hoboken), , - . doi:10.1002/acr.22466
    • Eleftheriou D, Isenberg DA, Wedderburn LR, Ioannou Y (2014). The coming of age of adolescent rheumatology.. Nat Rev Rheumatol, , - . doi:10.1038/nrrheum.2013.202
    • Botta Gordon-Smith SL, Ursu S, Eaton S, Moncrieffe H, Wedderburn LR (2014). Low CD73 expression on synovial lymphocytes correlates with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis. Arthritis and Rheumatism, , - . doi:10.1002/art.38959
    • Vercoulen Y, Bellutti Enders F, Meerding J, Plantinga M, Elst EF, Varsani H, van Schieveen C, Bakker MH, Klein M, Scholman RC, Spliet W, Ricotti V, Koenen HJ, de Weger RA, Wedderburn LR, van Royen-Kerkhof A, Prakken BJ (2014). Increased Presence of FOXP3+ Regulatory T Cells in Inflamed Muscle of Patients with Active Juvenile Dermatomyositis Compared to Peripheral Blood.. PLoS One, 9(8), e105353 - . doi:10.1371/journal.pone.0105353
    • Jani M, Massey J, Chinoy H, Warren RB, Griffiths CE, Wedderburn LR, Vencovský J, Danko K, Lundberg IE, Padyukov L, Selva-O'Callaghan A, Radstake T, Platt H, Ollier WE, Lamb JA, Lee A, Gregersen PK, Miller FW, Cooper RG (2014). Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies. Annals of the Rheumatic Diseases, 73(9), 1750 - 1752. doi:10.1136/annrheumdis-2014-205440
    • Bending D, Pesenacker AM, Ursu S, Wu Q, Lom H, Thirugnanabalan B, Wedderburn LR (2014). Hypomethylation at the Regulatory T Cell-Specific Demethylated Region in CD25hi T Cells Is Decoupled from FOXP3 Expression at the Inflamed Site in Childhood Arthritis.. J Immunol, , - . doi:10.4049/jimmunol.1400599
    • McCann LJ, Arnold K, Pilkington CA, Huber AM, Ravelli A, Beard L, Beresford MW, Wedderburn LR (2014). Developing a provisional, international Minimal Dataset for Juvenile Dermatomyositis: For use in clinical practice to inform research. Pediatric Rheumatology, , 31 - 31. doi:10.1186/1546-0096-12-31
    • Tansley SL, Betteridge ZE, Shaddick G, Gunawardena H, Arnold K, Wedderburn LR, McHugh NJ, on behalf of the Juvenile Dermatomyositis Research Group (2014). Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset.. Rheumatology (Oxford), , - . doi:10.1093/rheumatology/keu259
    • Tansley SL, Betteridge ZE, Gunawardena H, Jacques TS, Owens CM, Pilkington C, Arnold K, Yasin S, Moraitis E, Wedderburn LR, McHugh NJ (2014). Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study.. Arthritis Res Ther, 16(4), R138 - . doi:10.1186/ar4600
    • Jani M, Massey J, Wedderburn LR, Vencovsky J, Danko K, Lundberg IE, Padyukov L, Selva-O'Callaghan A, Radstake T, Platt H, Warren RB, Griffiths CE, Lee A, Gregersen PK, Miller FW, Ollier WE, Cooper RG, Chinoy H, Lamb JA, and EUMYONET (2014). Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.. Ann Rheum Dis, , - . doi:10.1136/annrheumdis-2014-205440
    • Cobb J, Cule E, Moncrieffe H, Hinks A, Ursu S, Patrick F, Kassoumeri L, Flynn E, Bulatović M, Wulffraat N, van Zelst B, de Jonge R, Bohm M, Dolezalova P, Hirani S, Newman S, Whitworth P, Southwood TR, De Iorio M, Childhood Arthritis Response to Medication Study (CHARMS), Childhood Arthritis Prospective Study (CAPS), BSPAR study group , Wedderburn LR, Thomson W (2014). Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.. Pharmacogenomics J, , - . doi:10.1038/tpj.2014.3
    • Eleftheriou D, Wedderburn LR, Isenberg DA, Ioannou Y (2014). The coming of age of adolescent rheumatology. Nature Reviews Rheumatology, 10(3), 187 - 193. doi:10.1038/nrrheum.2013.202
    • Piper C, Pesenacker AM, Bending D, Thirugnanabalan B, Varsani H, Wedderburn LR, Nistala K (2014). T cell GM-CSF expression in juvenile arthritis is contingent upon Th17 plasticity.. Arthritis Rheumatol, , - . doi:10.1002/art.38647
    • Duurland CL, Wedderburn LR (2014). Current developments in the use of biomarkers for juvenile idiopathic arthritis topical collection on pediatric rheumatology. Current Rheumatology Reports, 16(3), - . doi:10.1007/s11926-013-0406-3
    • Hawwa AF, Albawab A, Rooney M, Wedderburn LR, Beresford MW, McElnay JC (2014). A Novel Dried Blood Spot-LCMS Method for the Quantification of Methotrexate Polyglutamates as a Potential Marker for Methotrexate Use in Children.. PLoS One, 9(2), e89908 - . doi:10.1371/journal.pone.0089908
    • Duurland CL, Wedderburn LR (2014). Current developments in the use of biomarkers for juvenile idiopathic arthritis.. Curr Rheumatol Rep, 16(3), 406 - . doi:10.1007/s11926-013-0406-3
    • Wu Q, Pesenacker AM, Stansfield A, King D, Barge D, Foster HE, Abinun M, Wedderburn LR (2014). Immunological characteristics and T cell receptor clonal diversity in children with systemic juvenile idiopathic arthritis undergoing T cell depleted autologous stem cell transplantation.. Immunology, , - . doi:10.1111/imm.12245
    • Duurland CL, Wedderburn LR (2014). Current developments in the use of biomarkers for juvenile idiopathic arthritis.. Current rheumatology reports, 16(3), 406 - 406. doi:10.1007/s11926-013-0406-3

    2013

    • Jani M, Chinoy H, Lamb JA, Wedderburn L, Vencovsky J, Danko K, Lundberg I, Selva O'Callaghan A, Radstake T, Platt H, Ollier WE, Cooper RG (2013). Investigation of idiopathic inflammatory myopathy for shared genetic risk factors with other autoimmune diseases: results from the European Myositis Network.
    • Sallum AM, Varsani H, Holton JL, Marie SK, Wedderburn LR (2013). Morphometric analyses of normal pediatric brachial biceps and quadriceps muscle tissue.. Histol Histopathol, 28(4), 525 - 530.
    • McErlane F, Beresford MW, Baildam EM, Chieng SE, Davidson JE, Foster HE, Gardner-Medwin J, Lunt M, Wedderburn LR, Thomson W, Hyrich KL, Childhood APSCAPS (2013). Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset juvenile idiopathic arthritis.. Annals of the rheumatic diseases, 72(12), 1983 - 1988.
    • Gordon-smith SB, Eaton S, Ursu S, Wedderburn LR (2013). Lymphocytes from the inflamed joint of Juvenile Idiopathic Arthritis patients express reduced levels of CD73 and have a functional defect in adenosine production.
    • Rothmund F, Gerss J, Ruperto N, Däbritz J, Wittkowski H, Frosch M, Wulffraat NM, Wedderburn LR, Holzinger D, Gohar F, Vastert SJ, Brik R, Deslandre CJ, Melo-Gomes JA, Magalhães CS, Barcellona R, Russo R, Gattorno M, Martini A, Roth J, Foell D, for the Paediatric Rheumatology International Trials Organization (PRINTO) (2013). Validation of relapse risk biomarkers for routine use in patients with juvenile idiopathic arthritis.. Arthritis Care Res (Hoboken), , - . doi:10.1002/acr.22248
    • Pesenacker AM, Wedderburn LR (2013). T regulatory cells in childhood arthritis - novel insights.. Expert Rev Mol Med, 15, e13 - . doi:10.1017/erm.2013.14
    • McErlane F, Lunt M, Thomson W, Hyrich KL, Beresford MW, Baildam EM, Chieng SEA, Davidson JE, Gardner-Medwin J, Foster HE, Wedderburn LR (2013). Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset Juvenile idiopathic Arthritis. Annals of the Rheumatic Diseases, 72(12), 1683 - 1988. doi:10.1136/annrheumdis-2012-202031
    • Hinks A, Cobb J, Han B, Marion MC, Sudman M, Martin P, Bohnsack JF, Wedderburn LR, Haas JP, de Bakker P, Langefeld CD, Raychaudhuri S, Prahalad S, Thompson SD, Thomson W (2013). Analysis Of The MHC Region In a Large Cohort Of Juvenile Idiopathic Arthritis Cases Identifies Independent Effects At HLA-DRB1.
    • Ombrello MJ, Remmers EF, Tachmazidou I, Grom AA, Foell D, Martini A, Gattorno M, Ozen S, Prahalad S, Bohnsack JF, Ilowite NT, Mellins ED, Russo RAG, Len CA, Oliveira SK, Yeung RSM, Wedderburn LR, Anton J, Langefeld CD, Thompson SD, Zeggini E, Thomson W, Kastner DL, Woo P, Genetics ICA (2013). Genome Wide Association Meta-Analysis Implicates HLA-DRB1, The BTNL2/HLA-DRA region, and a Novel Susceptibility Locus On Chromosome 1 In Systemic Juvenile Idiopathic Arthritis.
    • Nistala K, Wedderburn LR (2013). Update in juvenile myositis. Current Opinion in Rheumatology, 25(6), 742 - 746. doi:10.1097/01.bor.0000434674.62644.02
    • Nistala K, Wedderburn LR (2013). Update in juvenile myositis.. Curr Opin Rheumatol, 25(6), 742 - 746. doi:10.1097/01.bor.0000434674.62644.02
    • Varsani H, Charman SC, Li CK, Marie SK, Amato AA, Banwell B, Bove KE, Corse AM, Emslie-Smith AM, Jacques TS, Lundberg IE, Minetti C, Nennesmo I, Rushing EJ, Sallum AM, Sewry C, Pilkington CA, Holton JL, Wedderburn LR, the UK Juvenile Dermatomyositis Research Group (2013). Validation of a score tool for measurement of histological severity in juvenile dermatomyositis and association with clinical severity of disease.. Ann Rheum Dis, , - . doi:10.1136/annrheumdis-2013-203396
    • Moncrieffe H, Ursu S, Pesenacker A, Gordon-Smith S, Zheng D, Wedderburn L (2013). Autoimmune susceptibility gene critically influences CD39 T cell expression and function in modulating human inflammation.
    • Miller FW, Cooper RG, Vencovsky J, Rider LG, Danko K, Wedderburn LR, Lundberg IE, Pachman LM, Reed AM, Ytterberg SR, Padyukov L, Selva-O'Callaghan A, Radstake T, Isenberg DA, Chinoy H, Ollier WE, O'Hanlon TP, Peng B, Lee A, Lamb JA, Chen W, Amos CI, Gregersen PK, Myositis Genetics Consortium (2013). Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.. Arthritis Rheum, , - . doi:10.1002/art.38137
    • Wickwar S, Buerkle K, McBain H, Ciciriello S, Osborne RH, Wedderburn LR, Newman SP (2013). Adaptation of the methotrexate in rheumatoid arthritis knowledge questionnaire (MiRAK) for use with parents of children with juvenile idiopathic arthritis: a qualitative study.. Pediatr Rheumatol Online J, 11(1), 27 - . doi:10.1186/1546-0096-11-27
    • Saunders E, Baildam E, Chieng A, Davidson J, Foster H, Gardner-Medwin J, Wedderburn L, Thomson W, Hyrich K (2013). FAMILY HISTORY OF AUTOIMMUNITY IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS: PREVALENCE AND INFLUENCE ON DISEASE PRESENTATION: RESULTS FROM THE UK CHILDHOOD ARTHRITIS PROSPECTIVE STUDY.
    • Wu Q, Pesenacker AM, Stansfield A, King D, Barge D, Abinun M, Foster HE, Wedderburn L (2013). T-CELL-DEPLETED AUTOLOGOUS STEM CELL TRANSPLANTATION RESULTS IN A CHIMERA OF CLONES FROM BEFORE AND AFTER TRANSPLANT IN SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS.
    • McErlane F, Beresford M, Baildam E, Chieng SE, Davidson J, Foster HE, Gardner-Medwin J, Lunt M, Wedderburn L, Thomson W, Hyrich K (2013). MINIMAL DISEASE ACTIVITY IN A CLINICAL COHORT OF CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS: RESULTS FROM THE CHILDHOOD ARTHRITIS PROSPECTIVE STUDY.
    • Mulligan K, Kassoumeri L, Etheridge A, Moncrieffe H, Wedderburn LR, Newman S (2013). Mothers' reports of the difficulties that their children experience in taking methotrexate for Juvenile Idiopathic Arthritis and how these impact on quality of life.. Pediatr Rheumatol Online J, 11(1), 23 - . doi:10.1186/1546-0096-11-23
    • Jethwa H, Jacques TS, Gunny R, Wedderburn LR, Pilkington C, Manzur AY (2013). Limb girdle muscular dystrophy type 2B masquerading as inflammatory myopathy: case report.. Pediatr Rheumatol Online J, 11(1), 19 - . doi:10.1186/1546-0096-11-19
    • Tansley SL, McHugh NJ, Wedderburn LR (2013). Adult and juvenile dermatomyositis: Are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?. Arthritis Research and Therapy, 15(2), - . doi:10.1186/ar4198
    • Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rosé CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P, Boston Children's JIA Registry , British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group , Childhood Arthritis Prospective Study (CAPS) , Childhood Arthritis Response to Medication Study (CHARMS) , German Society for Pediatric Rheumatology (GKJR) , JIA Gene Expression Study , NIAMS JIA Genetic Registry , TREAT Study , United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC) , Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD (2013). Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.. Nat Genet, 45(6), 664 - 669. doi:10.1038/ng.2614
    • Moncrieffe H, Ursu S, Holzinger D, Patrick F, Kassoumeri L, Wade A, Roth J, Wedderburn LR (2013). A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein.. Rheumatology (Oxford), 52(8), 1467 - 1476. doi:10.1093/rheumatology/ket152
    • Tansley SL, McHugh NJ, Wedderburn LR (2013). Adult and juvenile dermatomyositis: Are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?. Arthritis Research & Therapy, , - .
    • Pesenacker AM, Bending D, Ursu S, Wu Q, Nistala K, Wedderburn LR (2013). CD161 defines the subset of FoxP3+ T cells capable of producing pro-inflammatory cytokines.. Blood, , e-pub - . doi:10.1182/blood-2012-08-443473
    • Nistala K, Varsani H, Wittkowski H, Vogl T, Krol P, Shah V, Mamchaoui K, Brogan PA, Roth J, Wedderburn LR (2013). Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis. Arthritis Res Ther, 15, R131 - . doi:10.1186/ar4311

    2012

    • Carrasco R, Wedderburn LR, Foster HE, Baildam E, Gardner-Medwin J, Chieng A, Davidson J, Thomson W, Hyrich K (2012). PREDICTORS OF POOR GROWTH IN CHILDREN WITH EARLY JUVENILE IDIOPATHIC ARTHRITIS: RESULTS FROM THE CHILDHOOD ARTHRITIS PROSPECTIVE STUDY (CAPS). ANNALS OF THE RHEUMATIC DISEASES, 71, 268 - 268.
    • Chinoy H, Cooper RG, Li CK-C, Ollier WER, Platt H, Fertig N, Oddis CV, Varsani H, Wedderburn LR, Gunawardena H, Betteridge Z, Mchugh NJ (2012). Genetic association study of NF-κB genes in UK caucasian adult and juvenile onset idiopathic inflammatory myopathy. Rheumatology, 51(5), 794 - 799. doi:10.1093/rheumatology/ker379
    • Hinks A, Cobb J, Bowes J, Sudman M, Steel K, Marion M, Keddache M, Bohnsack J, Guthery S, Wedderburn L, Glass D, Haas JP, Prahalad S, Langefeld CD, Thomson W, Thompson SD (2012). ANALYSIS OF THE IMMUNOCHIP IN A LARGE COHORT OF OLIGO- AND POLYARTHRITIS JUVENILE IDIOPATHIC ARTHRITIS (JIA) CASES CONFIRMS PREVIOUS AND IDENTIFIES NOVEL ASSOCIATIONS. ANNALS OF THE RHEUMATIC DISEASES, 71, 127 - 127.
    • Jani M, Chinoy H, Lamb JA, Wedderburn L, Vencovsky J, Danko K, Lundberg I, O'Callaghan AS, Radstake T, Platt H, Ollier WE, Cooper RG, EUMYONET (2012). INVESTIGATION OF IDIOPATHIC INFLAMMATORY MYOPATHY FOR SHARED GENETIC RISK FACTORS WITH OTHER AUTOIMMUNE DISORDERS: RESULTS OF UK MYONET. ANNALS OF THE RHEUMATIC DISEASES, 71, 478 - 479.
    • McErlane F, Beresford M, Baildam E, Chieng SEA, Davidson J, Foster H, Gardner-Medwin J, Lunt M, Wedderburn LR, Thomson W, Hyrich KL (2012). MINIMAL DISEASE ACTIVITY IN A CLINICAL COHORT OF CHILDREN WITH JIA: RESULTS FROM THE CHILDHOOD ARTHRITIS PROSPECTIVE STUDY.
    • Lim D, Todd M, Kourtoglou N, Gerasimidis K, Gardner-Medwin J, Watson L, Tullus K, Pilkington C, Chesters C, Marks SD, Newland P, Jones C, Beresford MW, O'Neill P, Lee H, Tattersall R, McErlane F, Beresford M, Baildam E, Alice Chieng SE, Davidson J, Foster H, Gardner-Medwin J, Lunt M, Wedderburn LR, Thomson W, Hyrich KL, Kavirayani A, Thyagarajan MS, Ellis J, Helen Strike CN, Ramanan AV, Coda A, Davidson J, Fowlie P, Walsh J, Carline T, Santos D, Brimlow KW, Rangaraj S, Grant C, Little J, Helen Strike CN, Hinchcliffe A, Dick A, Ramanan A, Ekdawy D, Nagra G, Camina N, Edgerton J, Choi J, Lamb K, Hawley D, Rangaraj S, Cruikshank M, Sen E, Pain C, Leone V, Cruikshank M, Walsh J, on behalf of the SPARN Education Workgroup , Tattersall R, Hawley D, Dunkley L, Lee H, McMahon AM, Bale P, Armon K, Amin T, Wood M, Davies R, Southwood TR, Kearsley-Fleet L, Hyrich KL, on behalf of the BSPAR Etanercept Register , Kearsley-Fleet L, Baildam E, Beresford M, Davies R, Foster HE, Mowbray K, Southwood TR, Thomson W, Hyrich KL, Agarwal M, Kavirayani A, Ramanan AV, Ellis J, Smith E, Gray W, Taylor-Robinson D, Foster HE, Beresford MW, Morgan T, Watson L, Beresford MW, Gohar F, Watson L, Beresford MW, Artim-Esen B, Radziszewska A, Pericleous C, Rahman A, Giles I, Ioannou Y, Jashek D, Mosley E, Rangaraj S, Moraitis E, Arnold K, Pilkington C, Russell NJ, Roderick M, Ramanan A, Roderick M, Russell N, Ramanan AV, Smith NS, Wilson N, Gardner-Medwin J, Sen E, Chan M, Hardy E, Rapley T, Hensman P, Wraith JE, Foster H, Clarkson J, Gardner-Medwin J, Choudhery V, McVitty C, Davidson J, Hughes DH, Martin N, Warrier K, Sen E, Abinun M, Jandial S, O'Leary D, Staunton D, Lowry C, McSweeney N, Sen E, Abinun M, Friswell M, Foster H, Walsh A, Lowry C, Raja A (2012). BSPAR ANNUAL CONFERENCE ABSTRACTS * Oral presentations * O1. The impact of modern management on outcomes of JIA compared with healthy controls.. Rheumatology (Oxford), 51(12), viii2 - viii14. doi:10.1093/rheumatology/kes277
    • Cordingley L, Vracas T, Baildam E, Chieng A, Davidson J, Foster HE, Gardner-Medwin J, Wedderburn LR, Thomson W, Hyrich KL (2012). Juvenile-onset inflammatory arthritis: a study of adolescents' beliefs about underlying cause.. Rheumatology (Oxford), 51(12), 2239 - 2245. doi:10.1093/rheumatology/kes216
    • Omoyinmi E, Hamaoui R, Pesenacker A, Nistala K, Moncrieffe H, Ursu S, Wedderburn LR, Woo P (2012). Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis.. Rheumatology (Oxford), 51(10), 1881 - 1886. doi:10.1093/rheumatology/kes162
    • Wedderburn LR, Nistala K (2012). Immunology and Aetiology of Juvenile Idiopathic arthritis. In Foster HE, Brogan PA (Ed.), Paediatric Rheumatology (pp. - ). : OUP Oxford.
    • Gerss J, Roth J, Holzinger D, Ruperto N, Wittkowski H, Frosch M, Wulffraat N, Wedderburn L, Stanevicha V, Mihaylova D, Harjacek M, Len C, Toppino C, Masi M, Minden K, Saurenmann T, Uziel Y, Vesely R, Apaz MT, Kuester R-M, Elorduy MJR, Burgos-Vargas R, Ioseliani M, Magni-Manzoni S, Unsal E, Anton E, Balogh Z, Hagelberg S, Mazur-Zielinska H, Tauber T, Martini A, Foel D (2012). Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: A comparative study. Annals of the Rheumatic Diseases, , - .
    • Martin N, Krol P, Smith S, Beard L, Pilkington CA, Davidson J, Wedderburn LR, Juvenile Dermatomyositis Research Group (JDRG) (2012). Comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study.. Arthritis Care Res (Hoboken), 64(11), 1665 - 1672. doi:10.1002/acr.21753
    • Wedderburn LR, Martin N, Li CK (2012). Juvenile dermatomyositis: New insights and new treatment strategies. Therapeutic Advances in Musculoskeletal Disease, 4(1), 41 - 50. doi:10.1177/1759720X11424460
    • Ye Y, Van Zyl B, Ramanan A, Gillespie KM, Varsani H, Wedderburn LR (2012). Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis. Rheumatology (United Kingdom), 51(6), 987 - 991. doi:10.1093/rheumatology/ker430
    • Holzinger D, Kastrup A, Roth J, Foell D, Frosch M, Wittkowski H, Prince FHM, Otten MH, Van Suijlekom-Smit LWA, Ten Cate R, Hoppenreijs EPAH, Hansmann S, Moncrieffe H, Ursu S, Wedderburn LR (2012). The toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 71(6), 974 - 980. doi:10.1136/annrheumdis-2011-200598
    • Omoyinmi E, Hamaoui R, Bryant A, Woo P, Forabosco P, Hinks A, Thomson W, Ursu S, Wedderburn LR, Lewis CM (2012). Association of the IL-10 Gene Family Locus on Chromosome 1 with Juvenile Idiopathic Arthritis (JIA). PLoS ONE, 7(10), - . doi:10.1371/journal.pone.0047673
    • Hinks A, Cobb J, Eyre S, Martin P, Flynn E, Barton A, Worthington J, Thomson W, Bowes J, Sudman M, Glass DN, Thompson SD, Packham J, Langefeld CD, Martin S, Robinson JI, Morgan AW, Emery P, Wilson AG, Steer S, Hocking L, Reid DM, Harrison P, Wordsworth P, Baildam E, Brown L, Buckley J, Chieng A, Davidson J, Eltringham M, Foster H, Friswell M, Gardner-Medwin J, Gilbert P, Hyrich K, Jones J, Lal S, Lay M, Lydon C, Meijer A, Price V, Sim J, Todd M, Ward P, Wedderburn L, Abinum M, Becker M, Bell A, Craft A, Crawley E, David J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Woo P, Wyatt S (2012). Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. Annals of the Rheumatic Diseases, 71(7), 1117 - 1121. doi:10.1136/annrheumdis-2011-200814
    • Gerss J, Holzinger D, Foell D, Roth J, Wittkowski H, Frosch M, Ruperto N, Martini A, Wulffraat N, Wedderburn L, Stanevicha V, Mihaylova D, Harjacek M, Len C, Toppino C, Masi M, Minden K, Saurenmann T, Uziel Y, Vesely R, Apaz MT, Kuester R-M, Elorduy MJR, Burgos-Vargas R, Ioseliani M, Magni-Manzoni S, Unsal E, Anton J, Balogh Z, Hagelberg S, Mazur-Zielinska H, Tauber T (2012). Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: A comparative study. Annals of the Rheumatic Diseases, 71(12), 1991 - 1997. doi:10.1136/annrheumdis-2012-201329
    • Mcerlane F, Lunt M, Thomson W, Hyrich KL, Beresford MW, Baildam EM, Chieng SEA, Davidson JE, Gardner-Medwin J, Foster HE, Wedderburn LR (2012). Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, , - . doi:10.1136/annrheumdis-2012-202031
    • Verstappen SM, Carrasco R, Wedderburn LR, Foster H, Baildam E, Gardner-Medwin J, Chieng A, Davidson J, Thomson W, Hyrich KL (2012). METHOTREXATE SURVIVAL IN CHILDREN WITH JIA: RESULTS FROM THE CHILDHOOD ARTHRITIS PROSPECTIVE STUDY (CAPS). ANNALS OF THE RHEUMATIC DISEASES, 71, 423 - 424.

    2011

    • MONCRIEFFE H, Wedderburn LR (2011). Regulatory T cells in arthritis: Why do they fail?. In Hayashi RS (Ed.), Regulatory T Cells (pp. - ). : Nova Biomedical Books.
    • Krol P, Shah V, Eleftheriou D, Hong Y, Beresford M, Wedderburn L, Pilkington C, Brogan P (2011). Evidence for persistent endothelial injury and subclinical inflammation in juvenile dermatomyositis. CLIN EXP RHEUMATOL, 29(2), 376 - 376.
    • Lal SD, Adib N, Thomson W, Hyrich KL, McDonagh J, Baildam E, Wedderburn LR, Gardner-Medwin J, Davidson J, Foster HE, Chieng A (2011). Agreement between proxy and adolescent assessment of disability, pain, and well-being in juvenile idiopathic arthritis. Journal of Pediatrics, 158(2), 307 - 312. doi:10.1016/j.jpeds.2010.08.003
    • Wedderburn LR, Pilkington CA, Beresford MW (2011). Connective Tissue Disorders in Children. In Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (Ed.), RHEUMATOLOGY (pp. - ). : Elsevier.
    • Haas JD, Nistala K, Petermann F, Saran N, Chennupati V, Schmitz S, Korn T, Wedderburn LR, Förster R, Krueger A, Prinz I (2011). Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.. PLoS One, 6(5), e20171 - . doi:10.1371/journal.pone.0020171
    • Martin N, Smith S, Pilkington CA, Wedderburn LR, Krol P, Murray K, Davidson JE (2011). A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies. Rheumatology, 50(1), 137 - 145. doi:10.1093/rheumatology/keq261
    • Wedderburn LR (2011). Regulatory T cells in arthritis: why do they fail?. In Rudensky A, Sakaguchi S (Ed.), Regulatory T-Cells (pp. - ). : Nova Science Publishers, Inc.
    • Hinks A, Martin P, Lal S, Thomson W, Moncrieffe H, Ursu S, Kassoumeri L, Wedderburn LR, Weiler T, Glass DN, Thompson SD (2011). Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 70(8), 1395 - 1400. doi:10.1136/ard.2010.146191
    • Moncrieffe H, Nistala K, Eaton S, Wedderburn LR (2011). A novel defect: CD39+T cells are enriched in the inflamed joint but do not suppress.
    • Ursu S, Moncrieffe H, Kassoumeri L, Wedderburn LR (2011). Effects of Methotrexate (MTX) treatment on cytokine profile and gene expression in Juvenile Idiopathic Arthritis (JIA). CLIN EXP RHEUMATOL, 29(2), 445 - 445.
    • Southwood TR, Rahman JK, Cummins CL, Foster HE, Davidson JE, Hyrich KL, Cotter CB, Wedderburn LR, Hull RG, Venning HE (2011). Duration of etanercept treatment and reasons for discontinuation in a cohort of juvenile idiopathic arthritis patients. Rheumatology, 50(1), 189 - 195. doi:10.1093/rheumatology/keq308
    • Wedderburn LR (2011). Juvenile Dermatomyositis. In Elzouki AY, Harfi H, Nazer H, Stapleton FB, Oh O, Whitley RJ (Ed.), Textbook of Clinical Paediatrics (pp. - ). : Springer.

    2010

    • Nistala K, Cambrook H, Ursu S, Wedderburn LR, Adams S, Olivito B, Cimaz R, De Jager W, Evans JG, Bajaj-Elliott M (2010). Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proceedings of the National Academy of Sciences of the United States of America, 107(33), 14751 - 14756. doi:10.1073/pnas.1003852107
    • Moncrieffe H, Nistala K, Kamhieh Y, Wedderburn LR, Eddaoudi A, Eaton S, Evans J (2010). High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population. Journal of Immunology, 185(1), 134 - 143. doi:10.4049/jimmunol.0803474
    • Liu C, Zhu X, Wu Y, Gao B, Huang P, Tang P, Zhang S, Walter TS, Owens RJ, Stuart DI, Ren J, Wedderburn LR (2010). Structural and functional insights of RANKL-RANK interaction and signaling. Journal of Immunology, 184(12), 6910 - 6919. doi:10.4049/jimmunol.0904033
    • Foell D, Wittkowski H, Frosch M, Roth J, Wulffraat N, Wedderburn LR, Gerß J, Stanevicha V, Mihaylova D, Ferriani V, Tsakalidou FK, Foeldvari I, Cuttica R, Gonzalez B, Ravelli A, Martini A, Khubchandani R, Oliveira S, Armbrust W, Garay S, Vojinovic J, Norambuena X, Gamir ML, García-Consuegra J, Lepore L, Susic G, Corona F, Dolezalova P, Pistorio A, Ruperto N (2010). Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission a randomized clinical trial. JAMA - Journal of the American Medical Association, 303(13), 1266 - 1273. doi:10.1001/jama.2010.375
    • Edwards LA, Stephenson HN, Zilbauer M, Bajaj-Elliott M, Nistala K, Wedderburn LR, Mills DC, Wren BW, Dorrell N, Lindley KJ (2010). Delineation of the innate and adaptive T-cell immune outcome in the human host in response to campylobacter jejuniinfection. PLoS ONE, 5(11), - . doi:10.1371/journal.pone.0015398
    • Hinks A, Martin P, Flynn E, Eyre S, Barton A, Bowes J, Orozco G, Thomson W, Worthington J, Packham J, Martin S, Robinson JI, Morgan AW, Emery P, Wilson AG, Steer S, Hocking L, Reid DM, Harrison P, Wordsworth P, Baildam E, Brown L, Buckley J, Chieng A, Davidson J, Eltringham M, Foster H, Friswell M, Gardner-Medwin J, Gilbert P, Hyrich K, Jones J, Lal S, Lay M, Lydon C, Meijer A, Price V, Sim J, Todd M, Ward P, Wedderburn L, Abinum M, Becker M, Bell A, Craft A, Crawley E, David J, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Woo P, Wyatt S (2010). Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 69(12), 2169 - 2172. doi:10.1136/ard.2009.126938
    • Hunter PJ, Nistala K, Jina N, Eddaoudi A, Hubank M, Wedderburn LR, Thomson W (2010). Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. Arthritis and Rheumatism, 62(3), 896 - 907. doi:10.1002/art.27284
    • Moncrieffe H, Ursu S, Kassoumeri L, Etheridge A, Wedderburn LR, Hubank M, Hinks A, Martin P, Thomson W, Weiler T, Glass DN, Thompson SD (2010). Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: Correlation between gene expression and genotype. Pharmacogenetics and Genomics, 20(11), 665 - 676. doi:10.1097/FPC.0b013e32833f2cd0

    2009

    • Mulligan K, Etheridge A, Kassoumeri L, Wedderburn LR, Newman S (2009). Do mothers and fathers hold similar views about their child's arthritis?. Arthritis Care and Research, 61(12), 1712 - 1718. doi:10.1002/art.25008
    • Salomonsson S, Grundtman C, Lundberg IE, Zhang S-J, Lanner JT, Katz A, Westerblad H, Li C, Wedderburn LR, Nagaraju K (2009). Upregulation of MHC class I in transgenic mice results in reduced force-generating capacity in slow-twitch muscle. Muscle and Nerve, 39(5), 674 - 682. doi:10.1002/mus.21129
    • Walter TS, Owens RJ, Stuart DI, Ren J, Liu C, Gao B, Huang P, Tang P, Zhang S, Wedderburn LR (2009). Crystallization and preliminary X-ray analysis of mouse RANK and its complex with RANKL. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65(6), 597 - 600. doi:10.1107/S1744309109015735
    • Gunawardena H, McHugh NJ, Wedderburn LR, Chinoy H, Cooper RG, Betteridge ZE, North J, Ollier WER, Oddis CV, Ramanan AV, Davidson JE (2009). Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis. Arthritis and Rheumatism, 60(6), 1807 - 1814. doi:10.1002/art.24547
    • Hinks A, Ke X, Barton A, Eyre S, Bowes J, Worthington J, Thomson W, Thompson SD, Glass DN, Langefeld CD, Wilson AG, Morgan A, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Symmons D, Abinum M, Becker M, Bell A, Craft A, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Wedderburn L, Woo P, Wyatt S, Conaghan P, Quinn M, Keenan A-M, Hensor E, Kitcheman J, Gough A, Green M, Reece R, Hordon L, Helliwell P, Melsom R, Doherty S, Adebajo A, Harvey A, Jarrett S, Huson G, Isdale A, Martin M, Karim Z, McGonagle D, Pease C, Cox S, Bejarano V, Nam J, Brown C, Thomas C, Pickles D, Hammond A, Neville B, Fairclough A, Nunns C, Gill A, Green J, Rhys-Evans B, Padwell B, Madden J, Taylor L, Smith S, King H, Firth J, Heard J, Sigsworth L, Corscadden D, Henshaw K, Rashid L-H, Martin SG, Robinson JI (2009). Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis and Rheumatism, 60(1), 251 - 257. doi:10.1002/art.24187
    • Abinun M, Flood TJ, Cant AJ, Veys P, Gennery AR, Foster HE, Friswell M, Baildam E, Davidson J, Southwood TR, Livermore P, Wedderburn LR (2009). Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007). Molecular Immunology, 47(1), 46 - 51. doi:10.1016/j.molimm.2008.12.029
    • Hyrich KL, Lal SD, Thornton J, Adib N, Thomson W, Foster HE, Baildam E, Gardner-Medwin J, Davidson J, Wedderburn LR, Chieng A (2009). Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study. Rheumatology, 49(1), 116 - 122. doi:10.1093/rheumatology/kep352
    • Chinoy H, Payne D, Poulton KV, Fertig N, Betteridge Z, Gunawardena H, Davidson JE, Oddis CV, McHugh NJ, Wedderburn LR, Ollier WE, Cooper RG (2009). HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy.. Rheumatology (Oxford, England), 48(10), 1213 - 1217.
    • Hinks A, Barton A, Eyre S, Bowes J, Ke X, Worthington J, Thomson W, Shephard N, Cargill M, Wang E, Kennedy GC, John S, Abinum M, Becker M, Bell A, Craft A, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Wedderburn L, Woo P, Wyatt S (2009). Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. Arthritis and Rheumatism, 60(1), 258 - 263. doi:10.1002/art.24179
    • Wedderburn LR, Rider LG (2009). Juvenile dermatomyositis: new developments in pathogenesis, assessment and treatment. Best Practice and Research: Clinical Rheumatology, 23(5), 665 - 678. doi:10.1016/j.berh.2009.07.007
    • Nistala K, Woo P, Wedderburn LR (2009). Juvenile idiopathic arthritis. In Firestein GS, Budd RC, Harris Jr ED, McInnes IB, Ruddy S, Sergent JS (Ed.), Kelly's Textbook of Rheumatology (pp. 1657 - 1675). : Saunders Elsevier.
    • Li CK-C, Knopp P, Moncrieffe H, Varsani H, Gao B, Wedderburn LR, Shah S, Singh B, Nagaraju K (2009). Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: Implications for juvenile myositis. American Journal of Pathology, 175(3), 1030 - 1040. doi:10.2353/ajpath.2009.090196
    • Nistala K, Wedderburn LR (2009). Th17 and regulatory T cells: Rebalancing pro- and anti-inflammatory forces in autoimmune arthritis. Rheumatology, 48(6), 602 - 606. doi:10.1093/rheumatology/kep028
    • Moncrieffe H, Mato H, Wedderburn LR (2009). The 15th Paediatric Rheumatology European Society (PReS) Congress.. International Journal of Advances in Rheumatology, 6(4), 151 - 153.
    • Hunter PJ, Wedderburn LR (2009). Pediatric rheumatic disease: can molecular profiling predict the future in JIA?. Nat Rev Rheumatol, 5(11), 593 - 594. doi:10.1038/nrrheum.2009.215

    2008

    • Newton KR, Sala-Soriano E, Varsani H, Wedderburn LR, Goldblatt D, Stephenson JR (2008). Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cells. Immunology, 125(4), 469 - 479. doi:10.1111/j.1365-2567.2008.02860.x
    • Adib N, Hyrich K, Thornton J, Lunt M, Thomson W, Davidson J, Gardner-medwin J, Foster H, Baildam E, Wedderburn L (2008). Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: Results from the Childhood Arthritis Prospective Study. Rheumatology, 47(7), 991 - 995. doi:10.1093/rheumatology/ken085
    • Marhaug G, Shah V, Shroff R, Varsani H, Wedderburn LR, Pilkington CA, Brogan PA (2008). Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis.. Rheumatology (Oxford), 47(7), 1031 - 1037. doi:10.1093/rheumatology/ken136
    • Chinoy H, Platt H, Lamb JA, Ollier WER, Cooper RG, Betteridge Z, Gunawardena H, McHugh NJ, Fertig N, Oddis CV, Varsani H, Wedderburn LR, Davidson J (2008). The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British caucasian patients. Arthritis and Rheumatism, 58(10), 3247 - 3254. doi:10.1002/art.23900
    • Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P, Wedderburn LR (2008). Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis and Rheumatism, 58(3), 875 - 887. doi:10.1002/art.23291
    • Varsani H, Newton KR, Li CK, Wedderburn LR, Harding B, Holton JL (2008). Quantification of normal range of inflammatory changes in morphologically normal pediatric muscle. Muscle and Nerve, 37(2), 259 - 261. doi:10.1002/mus.20898
    • Elst EF, Klein M, De Jager W, Kuis W, Prakken BJ, Albani S, Kamphuis S, Wedderburn LR, Van Der Zee R (2008). Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis. Arthritis and Rheumatism, 58(2), 547 - 555. doi:10.1002/art.23202
    • Gunawardena H, Dunphy J, McHugh NJ, North J, Betteridge Z, Wedderburn LR, Chinoy H, Cooper RG, Davidson JE (2008). Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis. Rheumatology, 47(3), 324 - 328. doi:10.1093/rheumatology/kem359

    2007

    • McCann LJ, Li CKC, Varsani H, Wedderburn LR, Pilkington CA (2007). Failure to over express MHC-CLASS-1 on muscle biopsy in a case of amyopathic juvenile dermatomyositis. Clinical and Experimental Rheumatology, 25(1), 96 - 98.
    • Wedderburn LR, Varsani H, Mchugh NJ, Dunphy J, North J, Chinoy H, Cooper RG, Salway F, Ollier WEF, Mccann LJ, Davidson JE (2007). HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. Rheumatology, 46(12), 1786 - 1791. doi:10.1093/rheumatology/kem265
    • Flutter B, Fu H-M, Wedderburn L, Gao B (2007). An extra molecule in addition to human tapsin is required for surface expression of βm linked HLA-B4402 on murine cell. Molecular Immunology, 44(14), 3528 - 3536. doi:10.1016/j.molimm.2007.03.011
    • Wedderburn LR, Varsani H, Li CKC, Newton KR, Charman SC, Pilkington CA, Holton JL, Amato AA, Banwell B, Bove KE, Corse AM, Emslie-Smith A, Harding B, Hoogendijk J, Lundberg IE, Marie S, Minetti C, Nennesmo I, Rushing EJ, Sewry C (2007). International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: A tool for potential use in clinical trials. Arthritis Care and Research, 57(7), 1192 - 1201. doi:10.1002/art.23012
    • Wedderburn LR, King DJ (2007). Analysis of the T-cell receptor repertoire of synovial T-cells.. In (Ed.), (pp. 97 - 116). : .
    • Lamb R, Thomson W, Donn R, Ogilvie EM, Abinun M, Becker M, Bell A, Craft A, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Wedderburn L, Woo P, Wyatt S (2007). Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis. Arthritis and Rheumatism, 56(4), 1286 - 1291. doi:10.1002/art.22444
    • Prakken BJ, De Jager W, Wulffraat NM, Kuis W, Hoppenreijs EPAH, Wedderburn LR (2007). Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: A cross-sectional study. Annals of the Rheumatic Diseases, 66(5), 589 - 598. doi:10.1136/ard.2006.061853

    2006

    • McCann LJ, Wedderburn LR, Hasson N (2006). Juvenile idiopathic arthritis. Archives of Disease in Childhood: Education and Practice Edition, 91(2), - . doi:10.1136/adc.2004.066050
    • Wedderburn LR, Nistala K, Southwood T (2006). Immunopathology of the joint in juvenile idiopathic arthritis. In Malleson P, Limura Y, Southwood T, Szer I (Ed.), Arthritis in Children and Adolescents (pp. 272 - 279). : Oxford University Press.
    • Pharoah DS, Varsani H, Tatham RW, Newton KR, Wedderburn LR, de Jager W, Prakken BJ, Klein N (2006). Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells. Arthritis Research and Therapy, 8(2), - . doi:10.1186/ar1913
    • McCann LJ, Juggins AD, Maillard SM, Wedderburn LR, Pilkington CA, Davidson JE, Murray KJ (2006). The Juvenile Dermatomyositis National Registry and Repository (UK and Ireland) - Clinical characteristics of children recruited within the first 5 yr. Rheumatology, 45(10), 1255 - 1260. doi:10.1093/rheumatology/kel099
    • Foster H, Davidson J, Baildam E, Abinun M, Wedderburn LR (2006). Autologous haematopoeitic stem cell rescue (AHSCR) for severe rheumatic disease in children: Guidance for BSPAR members - Executive summary. Rheumatology, 45(12), 1570 - 1571. doi:10.1093/rheumatology/kel319a
    • Maillard SM, Wedderburn LR (2006). Myositis in Children. In Fenton J (Ed.), Living with Myositis (pp. 303 - 308). : Thoughtful Publications Inc..

    2005

    • Wedderburn LR, Woo P, Hull RG (2005). Paediatric rheumatology: A bright future in the UK and Europe. Rheumatology, 44(4), 423 - 425. doi:10.1093/rheumatology/keh574
    • Maillard SM, Jones R, Owens CM, Pilkington C, Woo PM, Wedderburn LR, Murray KJ (2005). Quantitative assessments of the effects of a single exercise session on muscles in juvenile dermatomyositis.. Arthritis and rheumatism, 53(4), 558 - 564.
    • Pilkington CA, Wedderburn LR (2005). Paediatric idiopathic inflammatory muscle disease: Recognition and management. Drugs, 65(10), 1355 - 1365. doi:10.2165/00003495-200565100-00004

    2004

    • Fife MF, Wythe H, Corrigal VM, Panayi GS, Wedderburn LR, Woo P, Bodman-Smith MD (2004). Anti-BiP antibody levels in juvenile idiopathic arthritis (JIA) [1]. Rheumatology, 43(10), 1305 - 1306. doi:10.1093/rheumatology/keh186
    • Wulffraat NM, De Kleer IM, Van Der Net J, Kuis W, Brinkman DMC, Ten Cate R, Van Rossum MAJ, Wedderburn LR, Ferster A, Horneff G, Oppermann J, Zintl F, Abinun M, Foster HE, Quartier P, Prieur AM, Fasth A (2004). Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: Analysis of clinical effects, mortality, and transplant related morbidity. Annals of the Rheumatic Diseases, 63(10), 1318 - 1326. doi:10.1136/ard.2003.017798
    • De Kleer IM, Klein M, De Jager W, Rijkers G, Kuis W, Prakken B, Wedderburn LR, Patel A, Varsani H, Taams LS, Pugayung G, Albani S, Giannoni F (2004). CD4CD25 Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis. Journal of Immunology, 172(10), 6435 - 6443.
    • Maillard SM, Pilkington C, Woo P, Wedderburn LR, Murray KJ, Jones R, Owens C (2004). Quantitative assessment of MRI T relaxation time of thigh muscles in juvenile dermatomyositis. Rheumatology, 43(5), 603 - 608. doi:10.1093/rheumatology/keh130
    • Wedderburn LR (2004). T cell regulation in juvenile arthritis. Pediatric Rheumatology Online Journal, May/June 2004(May), - .
    • Riley P, Maillard SM, Wedderburn LR, Woo P, Murray KJ, Pilkington CA (2004). Intravenous cyclosphosphamide pulse therapy in juvenile dermatomyositis. A review of efficacy and safety. Rheumatology, 43(4), 491 - 496. doi:10.1093/rheumatology/keh082
    • Wedderburn LR, Li CKC (2004). Paediatric idiopathic inflammatory muscle disease. Best Practice and Research: Clinical Rheumatology, 18(3), 345 - 358. doi:10.1016/j.berh.2004.01.003
    • Prais A, Thomson W, Donn R, McLean W, Reginato AM, Zeggini E, Abinun M, Becker M, Bell A, Craft A, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones L, Pountain G, Ryder C, Southwood T, Stewart I, Wedderburn L, Woo P, Wyatt S, Venning H (2004). Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. Rheumatology, 43(9), 1138 - 1141. doi:10.1093/rheumatology/keh261
    • Li CKC, Varsani H, Holton JL, Gao B, Woo P, Wedderburn LR (2004). MHC Class I Overexpression on Muscles in Early Juvenile Dermatomyositis. Journal of Rheumatology, 31(3), 605 - 609.

    2003

    • Woo P, van Kooyk Y, Varsani H, Patel A, Wedderburn LR (2003). Synovial dendritic cells in juvenile idiopathic arthritis (JIA) express receptors activator of NF-κB (RANK). Rheumatology, 42(4), 583 - 590.
    • Wedderburn LR, Abinun M, Palmer P, Foster HE (2003). Autologous haematopoietic stem cell transplantation in juvenile idiopathic arthritis. Archives of Disease in Childhood, 88(3), 201 - 205. doi:10.1136/adc.88.3.201
    • De Benedetti F, Meazza C, Vivarelli M, Rossi F, Pistorio A, Ravelli A, Martini A, Lamb R, Lunt M, Thomson W, Donn R, Abinun M, Becker M, Bell A, Craft A, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Wedderburn L, Woo P, Wyatt S (2003). Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis. Arthritis and Rheumatism, 48(5), 1398 - 1407. doi:10.1002/art.10882

    2002

    • Cameron TO, Stern LJ, Norris PJ, Rosenberg ES, Patel A, Wedderburn LR, Moulon C, Mellins ED (2002). Labeling antigen-specific CD4 T cells with class II MHC oligomers. Journal of Immunological Methods, 268(1), 51 - 69. doi:10.1016/S0022-1759(02)00200-4
    • Donn RP, Farhan A, Stevans A, Ramanan A, Ollier WER, Thomson W, Abinun M, Becker M, Bell A, Craft A, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountáin G, Ryder C, Southwood T, Stewart I, Venning H, Wedderburn L, Woo P, Wyatt S (2002). Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. Rheumatology, 41(8), 930 - 936.
    • Donn R, Zeggini E, Lunt M, Shelley E, Lamb R, Ollier WER, Thomson W, Alourfi Z, Stevens A, Ray D, De Benedetti F, Meazza C, Abinun M, Becker M, Bell A, Craft A, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick A, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Wedderburn L, Woo P, Wyatt S (2002). Mutation screening of the macrophage migration inhibitory factor gene: Positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis and Rheumatism, 46(9), 2402 - 2409. doi:10.1002/art.10492
    • Begum S, Li C, Wedderburn LR, Blackwell V, Isenberg DA (2002). Concurrence of sarcoidosis and systemic lupus erythematosus in three patients. Clinical and Experimental Rheumatology, 20(4), 549 - 552.

    2001

    • Favier B, Valitutti S, Burroughs NJ, Wedderburn L (2001). TCR dynamics on the surface of living T cells. International Immunology, 13(12), 1525 - 1532.
    • Wedderburn LR, Patel A, Varsani H, Woo P (2001). The developing human immune system: T-cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T-cell expansions. Immunology, 102(3), 301 - 309. doi:10.1046/j.1365-2567.2001.01194.x
    • Wedderburn LR, Jeffery R, Patel A, Varsani H, Murray K, Woo P, White H, Linch D (2001). Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: Changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO to RA phenotype. Rheumatology, 40(11), 1299 - 1307.
    • Wedderburn LR, Patel A, Varsani H, Woo P (2001). Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis. International Immunology, 13(12), 1541 - 1550.

    2000

    • Wedderburn LR (2000). Tracking T cells in arthritis. Rheumatology, 39(5), 458 - 462.
    • Wedderburn LR, Robinson N, Patel A, Varsani H, Woo P (2000). Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis.. Arthritis Rheum, 43(4), 765 - 774. doi:10.1002/1529-0131(200004)43:4<765::AID-ANR7>3.0.CO;2-B
    • Wedderburn LR, Dianda L (2000). T cells at the turn of the twenty-first century. Immunology Today, 21(3), 120 - 122. doi:10.1016/S0167-5699(99)01578-9
    • Mitchison NA, Wedderburn LR (2000). B cells in autoimmunity. Proceedings of the National Academy of Sciences of the United States of America, 97(16), 8750 - 8751. doi:10.1073/pnas.97.16.8750
    • Maini MK, Gudgeon N, Wedderburn LR, Rickinson AB, Beverley PCL (2000). Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype. Journal of Immunology, 165(10), 5729 - 5737.

    1999

    • Wedderburn LR, Maini MK, Patel A, Beverley PC, Woo P (1999). Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood.. Int Immunol, 11(4), 535 - 543.
    • Wedderburn LR, Woo P (1999). Type 1 and type 2 immune responses in children: Their relevance in juvenile arthritis. Springer Seminars in Immunopathology, 21(3), 361 - 374. doi:10.1007/s002810050072

    1998

    • Woo P, Wedderburn LR (1998). Juvenile chronic arthritis. LANCET, 351(9107), 969 - 973.
    • Maini MK, Beverley PCL, Wedderburn LR, Hall FC, Wack A, Casorati G (1998). A comparison of two techniques for the molecular tracking of specific T- cell responses; CD4 human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8 population. Immunology, 94(4), 529 - 535. doi:10.1046/j.1365-2567.1998.00556.x
    • Woo P, Wedderburn L (1998). Erratum: Juvenile chronic arthritis (The Lancet (1998) March 28 (971)). Lancet, 351(9111), 1292 - 1292.

    1995

    • Wedderburn LR, Owen MJ, Searle SJM, Rees AR, Lamb JR (1995). Mapping T cell recognition: The identification of a T cell receptor residue critical to the specific interaction with an influenza hemagglutinin peptide. European Journal of Immunology, 25(6), 1654 - 1662. doi:10.1002/eji.1830250627

    1994

    • Wedderburn LR, Bowness P (1994). Factors affecting TCR-repertoire diversity. Immunology Today, 15(1), 41 - 41. doi:10.1016/0167-5699(94)90026-4
    • Wedderburn LR (1994). How super are the superantigens?. Current medical Literature (Rheumatology), 13, 59 - 63.

    1993

    • Wedderburn LR, Owen MJ, O'Hehir RE, Hewitt CRA, Lamb JR (1993). In vivo clonal dominance and limited T-cell receptor usage in human CD4 T-cell recognition of house dust mite allergens. Proceedings of the National Academy of Sciences of the United States of America, 90(17), 8214 - 8218.
    • Bowman SJ, Wedderburn L, Whaley A, Grahame R, Newman S (1993). Outcome assessment after epidural corticosteroid injection for low back pain and sciatica. Spine, 18(10), 1345 - 1350.

    1992

    • Wedderburn LR, Kwan JTC, Thompson PWAR, R S (1992). Juvenile chronic arthritis and Wegener's granulomatosis.. British Journal of Rheumatology, 31(2), 121 - 123.

    1991

    • Kirkham B, Churchill M, Dasgupta B, Wedderburn L, Spencer J, Macfarlane DG (1991). Anterolateral rupture of popliteal cysts in rheumatoid arthritis. Annals of the Rheumatic Diseases, 50(3), 187 - 188.

    1989

    • Kirkham B, Wedderburn L, MacFarlane DG (1989). Gold-induced colitis. British Journal of Rheumatology, 28(3), 272 - 273.
    • Emery P, Bowman S, Wedderburn L, Grahame R (1989). Suprascapular nerve block for chronic shoulder pain in rheumatoid arthritis. British Medical Journal, 299(6707), 1079 - 1080.

    1984

    • Wedderburn L, Lukic ML, Edwards S, Kahan MC, Nardi N, Mitchison NA (1984). Single-step immunosorbent preparation of F-protein from mouse liver with conservation of the allo-antigenic site, and determination of concentration in liver and serum. Molecular Immunology, 21(10), 979 - 984.
    • Whittle HC, Brown J, Marsh K, Greenwood BM, Seidelin P, Tighe H, Wedderburn L (1984). T-cell control of Epstein-Barr virus-infected B cells is lost during P. falciparum malaria.. Nature, 312(5993), 449 - 450.