Dr Shi-Yu Yang

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Personal Profile

Name: Shi-Yu Yang Email: shiyu.yang@ucl.ac.uk
Title: Dr Tel: 442077940500 34385
Department: Clinical Neuroscience Fax:
Position: Senior Research Associate Address: Royal Free Campus, Rowland Hill Street, London, NW3 2PF
Research Domain: Basic Life Sciences, Cancer, Personalised Medicine, Populations & Lifelong Health Web Page: Personal Web Page

Profile

Research Description

Initially, I was studying the role of IGF-I in muscle development, growth and regeneration. The biggest accomplishment I have achieved in this field is successfully cloning the Mechano Growth Factor (MGF, an IGF-I isoform) from exercised muscle and demonstrated that MGF \"kick starts\" muscle hypertrophy and is important in local tissue repair. Following cloning MGF, I have directed my research on characterising this novel growth factor and its pharmaceutical applications. Based on my research, several highly active MGF C-peptides have been produced and marketed by biotech companies.

After marketing MGF, I have shifted my research towards the role of IGF-I signalling in solid cancer initiation, development and progress. Since then, I have made considerable progresses and demonstrated that IGF-I is implicated in colorectal cancer cell survival, migration and invasion. Based on the structure of IGF-I and its receptor, I have designed and developed an IGF-I receptor antagonist and established that this antagonist is able to disrupt the interaction between IGF-I and IGF-I receptor, and induce colorectal cancer cell apoptosis.

Research Activities

Colorectal Cancer Research Programme

Neuromuscular and Neurodegenerative Disorders

Education Description

My teaching at UCL involves lecturing and supervision of undergraduate and postgraduate students in the Division of Surgery & Interventional Science. I have initiated, established and organised a compulsory module entitled “Molecular Techniques” for the Intercalated BSc in Surgical Sciences. The course is designed to take advantage of new developments in molecular and cellular biology and their applications in Surgical Science and provides students with the latest laboratory techniques and their applications in the clinical and basic research problems. I also give lecturers to MSc students in the course of Nanotechnology & Regeneration Medicine, and supervise the research projects of two iBSc and two MSc students per year. I currently lead two laboratories, supervise three PhD and four MD students, and attend several divisional routine examine board and committee meetings.

UCL Collaborators

Prof Alan Thompson; Prof John Hardy; Dr Richard Orrell; Prof Elizabeth Fisher; Dr Bala Subramaniyam Ramesh; Prof Linda Greensmith; Prof Alexander Seifalian; Prof Francesco Muntoni

External Collaborators

Publications

    2014

    • Rizvi SB, Rouhi S, Taniguchi S, Yang SY, Green M, Keshtgar M, Seifalian AM (2014). Near-infrared quantum dots for HER2 localization and imaging of cancer cells.. Int J Nanomedicine, 9, 1323 - 1337. doi:10.2147/IJN.S51535

    2012

    • Abu-Amara M, Yang SY, Seifalian A, Davidson B, Fuller B (2012). The nitric oxide pathway--evidence and mechanisms for protection against liver ischaemia reperfusion injury.. Liver Int, 32(4), 531 - 543. doi:10.1111/j.1478-3231.2012.02755.x
    • Abu-Amara M, Yang SY, Quaglia A, Rowley P, Tapuria N, Fuller B, Davidson B, Seifalian A (2012). The hepatic soluble guanylyl cyclase-cyclic guanosine monophosphate pathway mediates the protection of remote ischemic preconditioning on the microcirculation in liver ischemia-reperfusion injury.. Transplantation, 93(9), 880 - 886. doi:10.1097/TP.0b013e31824cd59d
    • Klionsky DJ, Backues SK, Bartholomew CR, Bridges D, Gestwicki JE, Han T, Jin M, Kim JK, Lin JD, Lynch-Day MA, Mao K, Nair U, Parzych KR, Umekawa M, Wang K, Yen W-L, Zhao M, Olsen LJ, Abdalla FC, Marcondes M, Silva-Zacarin ECM, Silva-Zacarin E, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Chiarelli R, Roccheri MC, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Saitoh T, Al-Younes HM, Al-Zeer MA, Meyer TF, Albert ML, Albin RL, Dowling JJ, Alegre-Abarrategui J, Wade-Martins R, Aleo MF, Fanzani A, Rovetta F, Alirezaei M, Chisari FV, Whitton JL, Almasan A, Almonte-Becerril M, Kouri Flores JB, Amano A, Amaravadi R, Amarnath S, Fowler DH, Amer AO, Drew ME, Andrieu-Abadie N, Poirot M, Vindis C, Anantharam V, Kanthasamy AG, Kanthasamy A, Ann DK, Anoopkumar-Dukie S, Grant GD, Aoki H, Apostolova N, Arancia G, Condello M, Meschini S, Aris JP, Asanuma K, Tomino Y, Asare NYO, Ashida H, Askanas V, Nogalska A, Askew DS, Auberger P, Bost F, Gual P, Luciano F, Rocchi S, Baba M, Baehrecke EH, Bahr BA, Bai X-Y, Chen X, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Brunetti-Pierri N, Settembre C, Bamber BA, Bampton ETW, Melino G, Bánhegyi G, Bassham DC, Bast Jr RC, Fan Z, Lopez-Berestein G, Lu Z, Ozpolat B, Batoko H, Bay B-H, Beau I, Esclatine A, Béchet DM, Begley TJ, Behl C, Behrends C, Dikic I, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Sanchez AMJ, Bernassola F, Marfe G, Palumbo C, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Espert L, Blum JS, Boise LH, Lonial S, Sun S-Y, Bonaldo P, Sandri M, Boone DL, Bornhauser BC, Bourquin J-P, Bortoluci KR, Bossis I, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Nezis IP, Rusten TE, Stenmark H, Brenman JE, Brennand A, Michels PAM, Bresnick EH, Kang Y-A, Brest P, Hofman P, Mograbi B, Bristol ML, Gewirtz DA, Brookes PS, Johnson GVW, Brown EJ, Brumell JH, Huang J, Kim PK, Brunk UT, Kurz T, Bulman DE, Bultman SJ, Bultynck G, Parys JB, Burbulla LF, Krüger R, Bursch W, Butchar JP, Buzgariu W, Galliot B, Bydlowski SP, Cadwell K, Cahová M, Papackova Z, Cai D, Cai J, Cai Q, Calabretta B, Sotgia F, Calvo-Garrido J, Escalante R, Camougrand N, Manon S, Priault M, Campanella M, Campos-Salinas J, Gonzalez-Rey E, Oliver FJ, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Moreira PI, Carew JS, Nawrocki ST, Carlin CR, Carmignac V, Durbeej M, Carneiro LAM, Carra S, Kampinga HH, Caruso RA, Casari G, Casas C, Castino R, Isidoro C, Cebollero E, Reggiori F, Cecconi F, Ciriolo MR, Piacentini M, Celli J, Chaachouay H, Rodemann HP, Chae H-J, Chai C-Y, Chan DC, Chan EY, Coombs GH, Chang RC-C, Che C-M, Lok C-N, Sy L-K, Chen C-C, Lin W-W, Chen G-C, Yang WY, Chen G-Q, Chen M, Wang J, Chen Q, Chen SS-L, Ke P-Y, Lin Y-L, Chen W, Chen Y-G, Liu Y, Yu L, Chen Y, Guan J-L, Towns R, Wiley JW, Chen Y-J, Chen Z, Cheng A, Cheng CHK, Cheng Y, Wang H-G, Yang J-M, El-Deiry WS, Cheong H, Thompson CB, Cheong J-H, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang H-L, Chiba T, Chin L-S, Li L, Mao Z, Chiou S-H, Cho CH, Cho D-H, Choi AMK, Haspel JA, Henske EP, Nakahira K, Ryter SW, Choi D, Choi KS, Choi ME, Münger K, Chouaib S, Choubey D, Choubey V, Kaasik A, Chu CT, Rabinowich H, Chuang T-H, Chueh S-H, Chun T, Park OK, Chwae Y-J, Chye M-L, Ciarcia R, Florio S, Granato GE, Clague MJ, Clark RSB, Clarke PGH, Puyal J, Clarke R, Saha T, Codogno P, Coller HA, Colombo MI, Comincini S, Condorelli F, Cookson MR, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Helfrich MH, Hocking LJ, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Kaushik S, Koga H, Czaja MJ, Cullen JJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, De Groot JF, Fueyo J, Gomez-Manzano C, Jiang H, De Haan CAM, Monastyrska I, De M (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445 - 544. doi:10.4161/auto.19496
    • Knowles JP, Shi-Wen X, Haque SU, Bhalla A, Dashwood MR, Yang S, Taylor I, Winslet MC, Abraham DJ, Loizidou M (2012). Endothelin-1 stimulates colon cancer adjacent fibroblasts.. Int J Cancer, 130(6), 1264 - 1272. doi:10.1002/ijc.26090
    • Alagaratnam S, Johnson A, Seifalian A, Winslet M, Yang S (2012). Autophagy in cancer cells as a pro-survival mechanism.

    2011

    • Abu-Amara M, Yang S, Seifalian A, Fuller B, Davidson B (2011). Remote Ischemic Preconditioning Protects the Liver from Ischemia Reperfusion Injury through the sGC-cGMP Pathway.
    • Yang SY, Winslet M (2011). The igf system in carcinogenesis and its implication for cancer therapy.. Curr Oncol, 18(6), 301 - 302.
    • Rogge FJ, Kerdjoudj H, Yang SY, Seifalian AM, Grobbelaar AO (2011). In vivo engineering of a myotendinous junction: a cornerstone in skeletal muscle tissue engineering.
    • Yang SY, Winslet MC (2011). Dual role of autophagy in colon cancer cell survival.. Ann Surg Oncol, 18 Suppl 3, S239 - . doi:10.1245/s10434-011-1789-x
    • Abu-Amara M, Yang SY, Seifalian AM, Fuller B, Davidson BR (2011). Remote ischemic preconditioning by hindlimb occlusion prevents liver ischemic/reperfusion injury.. Ann Surg, 254(1), 178 - 180. doi:10.1097/SLA.0b013e318221ff34
    • Abu-Amara M, Yang SY, Quaglia A, Rowley P, de Mel A, Tapuria N, Seifalian A, Davidson B, Fuller B (2011). Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury.. Clin Sci (Lond), 121(6), 257 - 266. doi:10.1042/CS20100598
    • Miah A, Yang SY, Winslet M (2011). AKT pathway as a potential therapeutic target for treating metastatic colorectal cancer.
    • Bartnik A, Yang SY, Miah A, Chen YW, Winslet M (2011). Autophagy protects colon cancer cells against stress-induced death.
    • Rippel RA, Nayyer L, Yang SY, Birchall M, Butler P, Seifalian AM (2011). Development of scaffold for auricular tissue engineering using a novel nanocomposite polymer.
    • Pabari A, Sedaghati T, Yang SY, Butler P, Mosahebi A, Seifalian AM (2011). Differentiation of adipose derived stem cells to Schwann cells on a novel nanocomposite polymer.
    • Chan YW, Miah A, Bartnik A, Fuller B, Winslet M, Yang SY (2011). The role of P38 MAPK pathway in human colon cancer cell resistance to 5-Fluorouracil.. doi:10.1002/bjs.7521
    • Yang SY, Miah A, Sales KM, Fuller B, Seifalian AM, Winslet M (2011). Inhibition of the p38 MAPK pathway sensitises human colon cancer cells to 5-fluorouracil treatment.. Int J Oncol, 38(6), 1695 - 1702. doi:10.3892/ijo.2011.982
    • Bartnik A, Loizidou M, Winslet MC, Yang SY (2011). Autophagy and Colorectal Cancer Therapy. Oncology News, 5(6), 188 - 189.
    • Abu-Amara M, Yang S, Tapuria N, Fuller BJ, Davidson BR, Seifalian AM (2011). Reply.. Liver Transpl, 17(1), 96 - . doi:10.1002/lt.22215
    • Yang SY, Miah A, Pabari A, Winslet M (2011). Growth Factors and their receptors in cancer metastases.. Front Biosci (Landmark Ed), 16, 531 - 538.
    • Abu-Amara M, Yang SY, Seifalian A, Davidson B, Fuller B (2011). REMOTE ISCHAEMIC PRECONDITIONING PROTECTS THE HEPATIC MICROCIRCULATION FROM LIVER ISCHAEMIA REPERFUSION INJURY THROUGH THE NITRIC OXIDE/cyclicGMP PATHWAY. TRANSPL INT, 24, 7 - 7.
    • Pabari A, Yang SY, Mosahebi A, Seifalian AM (2011). Recent advances in artificial nerve conduit design: strategies for the delivery of luminal fillers.. J Control Release, 156(1), 2 - 10. doi:10.1016/j.jconrel.2011.07.001
    • Pabari A, Yang SY, Butler P, Mosahebi A, Seifalian AM (2011). Differentiation of schwann cells on a novel nanocomposite material for peripheral nerve regeneration.
    • Abu-Amara M, Yang SY, Quaglia A, Rowley P, Tapuria N, Seifalian AM, Fuller BJ, Davidson BR (2011). Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse model.. Liver Transpl, 17(1), 70 - 82. doi:10.1002/lt.22204
    • Abu-Amara M, Yang SY, Quaglia A, Rowley P, Fuller B, Seifalian A, Davidson B (2011). Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver.. Liver Transpl, 17(5), 610 - 619. doi:10.1002/lt.22272
    • Abu-Amara M, Yang S, Seifalian A, Fuller B, Davidson B (2011). Nitric Oxide in Remote Ischemic Preconditioning of the Liver: A Novel Role for an Old Molecule.
    • Sedaghati T, Yang SY, Mosahebi A, Alavijeh MS, Seifalian AM (2011). Nerve regeneration with aid of nanotechnology and cellular engineering.. Biotechnol Appl Biochem, 58(5), 288 - 300. doi:10.1002/bab.51

    2010

    • Pabari A, Yang SY, Seifalian AM, Mosahebi A (2010). Modern surgical management of peripheral nerve gap.. J Plast Reconstr Aesthet Surg, 63(12), 1941 - 1948. doi:10.1016/j.bjps.2009.12.010
    • Yang SY (2010). IGF IS A MAJOR PHYSIOLOGICAL REGULATOR, BUT NOT SOLELY RESPONSIBLE FOR MUSCLE MASS REGULATION. J APPL PHYSIOL, 108(6), 1826 - 1826.
    • Abu-Amara M, Yang SY, Tapuria N, Fuller B, Davidson B, Seifalian A (2010). Liver ischemia/reperfusion injury: processes in inflammatory networks--a review.. Liver Transpl, 16(9), 1016 - 1032. doi:10.1002/lt.22117
    • Yang SY, Miah A, Hoy M, Winslet M (2010). The tretment of colorectal cancer metastasis with IGF-I receptor antagonists. doi:10.1002/bjs.7351
    • Abu-Amara M, Yang SY, Seifalian AM, Davidson BR, Fuller B (2010). Nitric oxide and endothelial nitric oxide synthase activity are a prerequisite for the protective effect of hindlimb remote ischaemic preconditioning on liver ischaemia reperfusion injury. doi:10.1002/bjs.7351
    • Abu-Amara M, Yang SY, Seifalian AM, Davidson BR, Fuller B (2010). Mouse hindlimb remote ischaemic preconditioning reduces liver ischaemia reperfusion injury and improves microcirculatory blood flow. doi:10.1002/bjs.7351
    • Vasas P, Winslet M, Yang SY (2010). Interfering with IGF-I pathways to augment sensitivity of colon cancer cells to current chemotherapeutic agents. doi:10.1002/bjs.7351
    • Miah A, Yang SY, Hoy M, Vasas P, Winslet M (2010). Inhibition of P38 MAPK sensitizes human colorectal cancer cells to 5-fluorouracil treatment. doi:10.1002/bjs.7351
    • Rizvi SB, Green M, Darbyshire A, YANG S, Seifalian AM, Keshtgar M (2010). Development of a biocompatible fluorescent nanocrystal for sentinal lymph node biopsy. doi:10.1002/bjs.7351
    • Miah A, Yang SY, Winslet M (2010). Akt Pathway is involoved in colon cancer cell migration. European Journal of Surgical Oncology, 36(11), 1128 - 1129.
    • Taribagil S, Yang SY, Ramesh B, Seifalian AM, Winslet MC (2010). Conjugation of quantum dots with RGD peptides: colon cancer cell targeting and toxicity assay. BRITISH JOURNAL OF SURGERY, 97, 45 - 45.
    • Abu-Amara M, Yang S, Fuller B, Davidson B (2010). Hind limb remote ischaemic preconditioning induces hepatic iNOS expression leading to protection against liver IR injury.
    • Yang SY, Hoy M, Fuller B, Sales KM, Seifalian AM, Winslet MC (2010). Pretreatment with insulin-like growth factor I protects skeletal muscle cells against oxidative damage via PI3K/Akt and ERK1/2 MAPK pathways.. Lab Invest, 90(3), 391 - 401. doi:10.1038/labinvest.2009.139
    • Kumar Y, Mazurek S, Yang S, Failing K, Winslet M, Fuller B, Davidson BR (2010). In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines.. Tumour Biol, 31(2), 69 - 77. doi:10.1007/s13277-009-0010-3

    2009

    • Riddoch-Contreras J, Yang SY, Dick JRT, Goldspink G, Orrell RW, Greensmith L (2009). Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. Experimental Neurology, 215(2), 281 - 289. doi:10.1016/j.expneurol.2008.10.014
    • Li W, Yang SY, Hu ZF, Winslet MC, Wang W, Seifalian AM (2009). Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions.. Med Sci Monit, 15(12), BR357 - BR363.
    • Vasas P, Winslet MC, Yang SY (2009). Az inzulinszeru″ növekedési faktor (IGF) szerepe a sejtosztódási folyamatokban és a daganatokban. Orvosi Hetilap, 150(51), 2308 - 2312. doi:10.1556/OH.2009.28733
    • Yang SY, Winslet MC (2009). Apoptosis in Colorectal Tumorigenesis and Chemotherapy. In Chen GG, Lai PBS (Ed.), Apoptosis in Carcinogenesis and Chemotherapy (pp. 75 - 109). : Springer Verlag.
    • Yang SY, Sales KM, Fuller B, Seifalian AM, Winslet MC (2009). Apoptosis and colorectal cancer: implications for therapy.. Trends Mol Med, 15(5), 225 - 233. doi:10.1016/j.molmed.2009.03.003
    • Robertson JH, Yang SY, Winslet MC, Seifalian AM (2009). Functional blocking of specific integrins inhibit colonic cancer migration.. Clin Exp Metastasis, 26(7), 769 - 780. doi:10.1007/s10585-009-9276-5
    • Yang SY, Bolvin C, Sales KM, Fuller B, Seifalian AM, Winslet MC (2009). IGF-I activates caspases 3/7, 8 and 9 but does not induce cell death in colorectal cancer cells.. BMC Cancer, 9, 158 - . doi:10.1186/1471-2407-9-158

    2008

    • Durai R, Yang SY, Seifalian AM, Winslet MC (2008). Principles and applications of gene therapy in colon cancer. Journal of Gastrointestinal and Liver Diseases, 17(1), 59 - 67.
    • Robertson JH, Sarkar S, Yang SY, Seifalian AM, Winslet MC (2008). In vivo models for early development of colorectal liver metastasis.. Int J Exp Pathol, 89(1), 1 - 12. doi:10.1111/j.1365-2613.2007.00562.x
    • Yang SY, Sales KM, Loizidou M, Winslet M (2008). Colorectal cancer: Chemotherapy resistance, apoptosis and future directions in therapy.. , 3(1), 20 - 21.
    • Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C (2008). Mechano-Growth Factor Reduces Loss of Cardiac Function in Acute Myocardial Infarction. Heart Lung and Circulation, 17(1), 33 - 39. doi:10.1016/j.hlc.2007.04.013
    • Wong Te Fong LF, Cortes E, Perrett CW, Crow JC, Goldspink G, Yang SY, Maclean AB (2008). Vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) isoforms in epithelial ovarian cancer (EOC). BJOG-INT J OBSTET GY, 115(1), 118 - 119.
    • Robertson JH, Yang SY, Iga AM, Seifalian AM, Winslet MC (2008). An in vivo rat model for early development of colorectal cancer metastasis to liver.. Int J Exp Pathol, 89(6), 447 - 457. doi:10.1111/j.1365-2613.2008.00605.x
    • Yang SY, Sales KM, Fuller BJ, Seifalian AM, Winslet MC (2008). Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide. Molecular Cancer, 7, - .

    2007

    • Ates K, Yang SY, Orrell RW, Sinanan AC, Simons P, Solomon A, Beech S, Goldspink G, Lewis MP (2007). The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle.. FEBS Letters, 581(14), 2727 - 2732.
    • Durai R, Yang SY, Sales KM, Seifalian AM, Goldspink G, Winslet MC (2007). Increased apoptosis and decreased proliferation of colorectal cancer cells using insulin-like growth factor binding protein-4 gene delivered locally by gene transfer. Colorectal Disease, 9(7), 625 - 631.
    • Durai R, Yang SY, Sales KM, Seifalian AM, Goldspink G, Winslet MC (2007). Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. International Journal of Oncology, 30(4), 883 - 888.
    • Durai R, Yang SY, Seifalian AM, Goldspink G, Winslet MC (2007). Role of insulin-like growth factor binding protein-4 in prevention of colon cancer. World J.Surg.Oncol., 5, 128 - .

    2006

    • Durai R, Davies M, Yang W, Yang SY, Seifalian A, Goldspink G, Winslet M (2006). Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). International Journal of Oncology, 28(6), 1317 - 1325.
    • Ates K, Yang S, Sinanan A, Golspink G, Lewis M (2006). Effects of MGF on human muscle stem cell proliferation in dystrophic, ALS and healthy human muscle.

    2005

    • Mckoy G, Hou Y, Yang SY, Vega Avelaira D, Degens H, Goldspink G, Coulton GR (2005). Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function. Journal of Applied Physiology, 98(6), 2337 - 2343.
    • Cortes E, te Fong LFW, Hameed M, Harridge S, Maclean A, Yang SY, Reid WM, Goldspink G (2005). Insulin-like growth factor-1 gene splice variants as markers of muscle damage in levator ani muscle after the first vaginal delivery. American Journal of Obstetrics and Gynecology, 193(1), 64 - 70. doi:10.1016/j.ajog.2004.12.088
    • Cheema U, Brown R, Mudera V, Yang SY, McGrouther G, Goldspink G (2005). Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscle. doi:10.1002/jcp.20107
    • Riddoch-Contreras J, Yang SY, Goldspink G, Orrell RW, Greensmith L (2005). Treatment with mechano-growth factor, an IGF-1 splice variant, rescues motoneurons and delays disease progression in SOD1 G93A mice..
    • Goldspink G, Yang SY, Hameed M, Harridge S, Bouloux P (2005). The role of MGF and Other IGF-I Splice Variants in Muslce Maintenance and Hypertrophy. In Kraemer WJ, Rogol AD (Ed.), The endocrine system in sports and exercise (pp. 180 - 193). : Wiley-Blackwell.

    2004

    • Hansen JC, Desei A, Yang SY, Matthews KG, Devlin GP, Goldspink G, Goldspink PH (2004). A locally expressed splice variant of IGF-I reduces ischemic injury after myocardial infarction by inhibiting apoptosis.
    • Ryten M, Yang SY, Dunn PM, Goldspink G, Burnstock G (2004). Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures.. FASEB J, 18(12), 1404 - 1406. doi:10.1096/fj.03-1175fje
    • McMahon CD, Devlin GP, Matthews KG, Goldspink PH, Yang SY, Conaglen JV, Bass JJ, Goldspink G (2004). Mechano-growth factor reduces ischaemic injury after myocardial infarction.
    • Hansen JC, Desei A, Yang SY, Matthews KG, McMahon CD, Devlin GP, Goldspink G, Goldspink PH (2004). A locally expressed splice variant of IGF-I reduces ischemic injury after myocardial infarction by inhibiting apoptosis.
    • Goldspink G, Yang SY (2004). The splicing of the IGF-I gene to yield different muscle growth factors. In Hall J, Dunlap J, Friedman T (Ed.), Advances in Genetics Volume 52: (pp. 23 - 49). : Elsevier Academic Press.
    • McMahon CD, Devlin GP, Matthews KG, Goldspink PH, Yang SY, Srai SKS, Ramesh B, Conaglen JV, Bass JJ, Goldspink G (2004). Acute protein administration, but not gene therapy with mechano-growth factor (MGF) reduces the severity of myocardial infarction.
    • Aperghis M, Johnson IP, Cannon J, Yang SY, Goldspink G (2004). Different levels of neuroprotection by two insulin-like growth factor-I splice variants. Brain Research, 1009, 213 - 218.

    2003

    • Aperghis M, Johnson IP, Cannon J, Yang S, Goldspink G (2003). Protection of axotomised adult facial motoneurons with a splice variant of IGF-1 isolated from active skeletal muscle.
    • Yang SY, Tohill M, Sutton DA, Dijk S, Williams PE, Terenghi G, Goldspink G (2003). Effects of MGF, an IGF-I spliced variant, on re-innervations of muscle.

    2002

    • Cheema U, Mudera V, Brown RA, Yang S, Goldspink G (2002). Mechanical loading of 3-D muscle constructs.
    • Yang SY, Goldspink GE (2002). Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Letters, 522(1-3), 156 - 160.

    2001

    • Owino V, Yang SY, Goldspink G (2001). Age-related loss of skeletal muscle function and the inability to express the autocrine form of insulin-like growth factor-1 (MGF) in response to mechanical overload. FEBS Letters, 505(2), 259 - 263.
    • Goldspink G, Yang SY (2001). Chapter 7 Gene expression associated with muscle adaptation in response to physical signals. Cell and Molecular Response to Stress, 2(C), 87 - 96. doi:10.1016/S1568-1254(01)80009-7
    • Goldspink G, Yang SY (2001). Effects of activity on growth factor expression. International Journal of Sport Nutrition and Exercise Metabolism, 11, S21 - S27.
    • Goldspink G, Yang SY (2001). Gene expression associated with muscle adaptation to physical signals. In Storey KB, Storey JM (Ed.), Protein Adaptations and Signal Transduction. Vol.2 (pp. 87 - 96). : Elsevier.
    • Cheema U, Goldspink G, Yang SY, Mudera V, Brown RA (2001). Precursor muscle organoids in 3D culture.

    2000

    • Kemp TJ, Sadusky TJ, Saltisi F, Carey N, Moss J, Yang SY, Sassoon DA, Goldspink G, Coulton GR (2000). Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein. Genomics, 66(3), 229 - 241.
    • Johnson IP, Cannon G, Goldspink G, Yang SY, Aperghis M (2000). Rescue of injured adult motoneurones with the gene for a splice variant of IGF-1 (MGF) isolated from skeletal muscle. Society for Neuroscience Abstracts, 26(2), 792 - .

    1999

    • Mckoy G, Ashley W, Mander J, Yang SY, Williams N, Russell B, Goldspink G (1999). Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation. The Journal of Physiology, 516(2), 583 - 592.

    1998

    • Skarli M, Yang SY, Bouloux P, Yellon DM, Goldspink G (1998). Up-regulation and alternative splicing of the IGF-1 gene in the rabbit heart following a brief pressure/volume overload. J PHYSIOL-LONDON, 509P, 192P - 193P.

    1997

    • Yang SY, Alnaqeeb M, Simpson H, Goldspink G (1997). Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch. Journal of Anatomy, 190, 613 - 622.

    1996

    • Goldspink C, Yang SY, Skarli M, Vrbova G (1996). Local growth regulation is associated with an isoform of IGF-1 that is expressed in normal muscles but not in dystrophic mdx or dydy mouse muscles when subjected to stretch. J PHYSIOL-LONDON, 495P, P162 - P163.
    • Yang SY, Alnaqeeb M, Simpson H, Goldspink G (1996). Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. Journal of Muscle Research and Cell Motility, 17(4), 487 - 495.

    • Miah A, Yang SY, Winslet M (). Akt pathway as a potential therapeutic target for treating metastatic.
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