Dr Suellen Walker

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Personal Profile

Name: Suellen Walker Email: suellen.walker@ucl.ac.uk
Title: Dr Tel: 0044 20 7905 2382
Department: ICH - Portex Anaesthesia Fax: 0044 20 7829 8634
Position: Clinical Senior Lecturer / Honorary Consultant Address: Portex Unit: Pain Research; 6th Floor Cardiac Wing; UCL Inst, , London, WC1N 1EH
Research Domain: Neuroscience, Reproduction & Development Web Page: Personal Web Page

Profile

Research Description

  • Developmental neurobiology of pain and long-term impact of early pain and injury 
  • Developmental pharmacodynamic profile of analgesics: efficacy and spinal toxicity
  • Clinical studies utilising quantitative sensory testing to assess impact of early pain and injury 
  • Sensory changes and psychological factors associated with chronic pain in children and adolescents.
  • Evidence-based acute pain management guidelines 


Research Activities

Clinical studies utilising quantitative sensory testing to assess impact of early pain and injury

Developmental neurobiology of pain and long-term impact of early pain and injury

Developmental pharmacodynamic profile of analgesics: efficacy and spinal toxicity

Evidence-based acute pain management guidelines

Factors associated with chronic pain in children and adolescents

Education Description

  • ANAT 3025 Advanced Functional Neuroanatomy Neuroanatomy of Sleep and Mechanisms of Anaesthesia
  • ANAT3042 Pain Module Pain in Neonates and Children
  • Faculty of Pain Medicine, Local Educational Supervisor for Advanced Pain Training, Great Ormond St Hospital    

UCL Collaborators

External Collaborators

Publications

    2012

    • Beggs S, Currie G, Salter MW, Fitzgerald M, Walker SM (2012). Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity.. Brain, 135((Pt 2)), 404 - 417.
    • Walker SM (2012). Perioperative care of neonates with Down's syndrome: should it be different?. BRITISH JOURNAL OF ANAESTHESIA, 108(2), 177 - 179. doi:10.1093/bja/aer452
    • Walker SM, Grafe M, Yaksh TL (2012). Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity. Anesth Analg, 115, 450 - 460. doi:10.1213/ANE.0b013e3182501a09
    • Walker SM, Yaksh TL (2012). Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg, 115, 638 - 662. doi:10.1213/ANE.0b013e31826253f2
    • Lonnqvist PA, Walker SM (2012). Ketamine as an adjunct to caudal block in neonates and infants: is it time to re-evaluate?. Br J Anaesth, 109, 138 - 140. doi:10.1093/bja/aes228

    2011

    • Walker SM, Grafe M, Yaksh TL (2011). Sublethal Spinal Ketamine Produces Neuronal Apoptosis in Rat Pups Reply. ANESTHESIOLOGY, 114(3), 719 - 721. doi:10.1097/ALN.0b013e31820a86b3

    2010

    • Westin BD, Walker SM, Deumens R, Grafe M, Yaksh TL (2010). Validation of a Preclinical Spinal Safety Model Effects of Intrathecal Morphine in the Neonatal Rat. ANESTHESIOLOGY, 113(1), 183 - 199. doi:10.1097/ALN.0b013e3181dcd6ec
    • Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL (2010). Effects of Intrathecal Ketamine in the Neonatal Rat Evaluation of Apoptosis and Long-term Functional Outcome. ANESTHESIOLOGY, 113(1), 147 - 159. doi:10.1097/ALN.0b013e3181dcd71c
    • Maintyre P, Schug S, Scott D, Visser E, Walker S (2010). Acute Pain Management: Scientific Evidence.
    • Macintyre PE, Walker SM (2010). The scientific evidence for acute pain treatment. CURR OPIN ANESTHESIO, 23(5), 623 - 628. doi:10.1097/ACO.0b013e32833c33ed

    2009

    • Walker SM, Franck LS, Fitzgerald M, Myles J, Stocks J, Marlow N (2009). Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm. PAIN, 141(1-2), 79 - 87.
    • Walker SM, Tochiki KK, Fitzgerald M (2009). Hindpaw incision in early life increases the hyperalgesic response to repeat surgical injury: critical period and dependence on initial afferent activity. Pain, 147(1-3), 99 - 106. doi:10.1016/j.pain.2009.08.017
    • Li J, Walker SM, Fitzgerald M, Baccei ML (2009). Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury. Journal of Neurophysiology, 102(4), 2208 - 2219. doi:10.1152/jn.00520.2009
    • Fitzgerald M, Walker SM (2009). Infant pain management: a developmental neurobiological approach.. Nat Clin Pract Neurol., 5(1), 35 - 50.
    • Walker SM (2009). Mechanisms of Inflammatory Hyperalgesia. In Macintyre PE, Walker SM, Rowbotham DJ (Ed.), Clinical Pain Management: Acute Pain (pp. 20 - 31). : Hodder Arnold.
    • Walker SM, Yaksh TL (2009). New caudal additives in children: benefit vs. risk?. doi:10.1111/j.1399-6576.2009.02013.x

    2008

    • Macintyre P, Walker S, Rowbotham D (2008). Clinical Pain Management: Acute Pain.
    • Walker SM (2008). Pediatrics and Pain Outcomes. In Wittink HM, Carr DB (Ed.), Pain Management: Evidence Outcomes and Quality of Life A Sourcebook (pp. 177 - 202). : Elsevier.
    • Walker SM (2008). Developmental Aspects of Nociception. In Cousins MJ, Bridenbaugh PO, Carr D, Horlocker T (Ed.), Neural Blockade (pp. 651 - 660). : Lippincott, Williams & Wilkins.
    • Walker SM (2008). Developmental Neurobiology of Nociception. In (Ed.), Clinical Pain Management: Acute Pain (pp. 32 - 52). : Hodder Arnold.
    • Walker SM (2008). Mechanisms of Inflammatory Hyperalgesia. In Macintyre PE, Walker SM, Rowbotham DJ (Ed.), Clinical Pain Management: Acute Pain (pp. 20 - 31). : Hodder Arnold.
    • Walker SM (2008). Pain in children: recent advances and ongoing challenges. Br J Anaesth, 101(1), 101 - 110.
    • Howard R, Carter B, Curry J, Morton N, Rivett K, Rose M, Tyrrell J, Walker S, Williams G (2008). Good practice in postoperative and procedural pain management.. Paediatr Anaesth, 18 Suppl 1, 1 - 78.
    • Macintyre PE, Walker SM, Rowbotham DJ (2008). Clinical Pain Management: Acute Pain..
    • Walker SM, Franck LS, Fitzgerald M, Stocks J, Marlow N (2008). Long-term impact of neonatal intensive care and surgery on somatosensory perception in extremely preterm children.

    2007

    • Walker SM (2007). Effects of anaesthetics on the developing brain - experimental results in animals.
    • Walker SM, Fitzgerald M (2007). Neonatal hindpaw incision produces acute and persistent alterations in nociceptive processing in the rat.
    • Walker SM (2007). Acute presentation of complex regional pain syndrome. In Schmidt RF, Willis WD (Ed.), Encyclopedia of Pain (pp. 1863 - 1866). : Springer.
    • Walker SM, Meredith-Middleton J, Lickiss T, Moss A, Fitzgerald M (2007). Primary and secondary hyperalgesia can be differentiated by postnatal age and ERK activation in the spinal dorsal horn of the rat pup. Pain, 128(1-2), 157 - 168. doi:10.1016/j.pain.2006.09.015
    • Walker SM, Fitzgerald M (2007). Characterization of spinal alpha-adrenergic modulation of nociceptive transmission and hyperalgesia throughout postnatal development in rats. British Journal of Pharmacology, 151(8), 1334 - 1342. doi:10.1038/sj.bjp.0707290

    2006

    • Collins JJ, Walker SM (2006). Introduction to Pain. In Goldman A, Hain R, Liben S (Ed.), Oxford Textbook of Palliative Care for Children (pp. 268 - 280). : Oxford University Press.
    • Hathway G, Harrop E, Baccei M, Walker S, Moss A, Fitzgerald M (2006). A postnatal switch in GABAergic control of spinal cutaneous reflexes. European Journal of Neuroscience, 23(1), 112 - 118.
    • Schug SA, Macintyre P, Power I, Scott D, Visser E, Walker S (2006). The scientific evidence in acute pain management.. Acute Pain, 7, 161 - 165.
    • Macintyre PE, Walker S, Power I, Schug SA (2006). .Acute pain management: scientific evidence revisited.. British Journal of Anaesthesia, 96, 1 - 4.
    • Fitzgerald M, Walker S (2006). Infant pain traces. Pain, 125(3), 204 - 205. doi:10.1016/j.pain.2006.09.029
    • Walker SM, Macintyre PE, Visser E, Scott D (2006). Acute pain management: current best evidence provides guide for improved practice. PAIN MED, 7(1), 3 - 5.

    2005

    • Walker SM, Howard RF, Fitzgerald M (2005). The effect of epidural dexmedetomidine is developmentally regulated in models of inflammatory and chemical hyperalgesia in the rat pup..
    • Walker SM (2005). Management of procedural pain in NICUs remains problematic. Paediatric Anaesthesia, 15(11), 909 - 912.
    • Howard RF, Walker SM, Mota PM, Fitzgerald M (2005). The ontogeny of neuropathic pain: postnatal onset of mechanical allodynia in rat spared nerve injury (SNI) and chronic constriction injury (CCI) models. Pain, 115(3), 382 - 389. doi:10.1016/j.pain.2005.03.016
    • Walker SM, Howard RF, Keay KA, Fitzgerald M (2005). Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pups. Anesthesiology, 102(6), 1226 - 1234. doi:10.1097/00000542-200506000-00024

    2004

    • Walker S, Howard RF (2004). Neonatal Pain. Pain Reviews, 9, 69 - 79.

    2003

    • Walker SM, Cousins MJ (2003). Anesthesiological Procedures.. In Bruera E, Portenoy R (Ed.), Cancer Pain. Assessment and Management. (pp. 201 - 227). : Cambridge University Press.
    • Fitzgerald M, Walker S (2003). The role of activity in developing pain pathways. In Dostrovsky JO, Carr DB, Koltzenburg M (Ed.), Proceedings of the 10th World Congress on Pain. Progress in Pain Research and Management, Volume 24 (pp. 54 - 68). : IASP Press.
    • Walker SM, Meredith-Middleton J, Cooke-Yarborough C, Fitzgerald M (2003). Neonatal inflammation and primary afferent terminal plasticity in the rat dorsal horn. Pain, 105(1-2), 185 - 195. doi:10.1016/S0304-3959(03)00201-X

    • Wong I, St John-Green C, Walker SM (). Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children. Pediatric Anesthesia, , n/a - n/a. doi:10.1111/pan.12163
    • Hamurtekin E, Fitzsimmons BL, Shubayev VI, Grafe MR, Deumens R, Yaksh TL, Walker SM (). Evaluation of Spinal Toxicity and Long-term Spinal Reflex Function after Intrathecal Levobupivaciane in the Neonatal Rat. Anesthesiology, , 1 - 1. doi:10.1097/ALN.0b013e31828fc7e7