Prof Parmjit Jat

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Personal Profile

Name: Parmjit Jat Email: p.jat@ucl.ac.uk
Title: Prof Tel: 020 7837 3973
Department: Neurodegenerative Diseases Fax: 020 7676 2180
Position: Professor of Neurodegenerative Disease Address: Department of Neurodegenerative Disease, UCL Institute of Ne, Queen Square, London, WC1N 3BG
Research Domain: Basic Life Sciences, Neuroscience, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

Normal somatic cells undergo a finite number of divisions and then cease dividing whereas cancer cells are able to proliferate indefinitely. This irreversible program of cell cycle arrest is triggered in response to a variety of intrinsic and extrinsic stimuli including alteration in telomere length and structure, DNA damage, physiological stresses and activation of certain oncogenes. It can lead to removal of defective and potentially cancerous cells from the proliferating pool thereby preventing neoplastic transformation and tumour development. It can also compromise tissue repair and regeneration and contribute to organismal ageing. The acquisition of an infinite proliferative potential is one of the six key events that are required for neoplastic transformation and one of the least understood since the underlying mechanism that controls cellular senescence and the signal transduction pathways involved are poorly understood. My research is aimed at identifying the underlying molecular basis for the finite proliferative life span and then if and how the key components are abrogated in cancer cells. We also aim to determine if these key components are conserved across species and in different cell types. Such components should represent novel, important and direct targets for both cancer and anti-ageing therapies.

Research Activities

Cellular mechanisms underlying neurodegeneration

Identification of new components in Parkinson's Disease signalling pathways

Education Description

UCL Collaborators

Prof David Jones; Prof John Hardy; Prof Ivan Gout; Prof John Collinge; Prof Sarah Tabrizi; Dr Peter-Christian Kloehn; Dr Marc Soutar; Dr Helene Plun-Favreau; Dr Stephanie Schorge; Prof Mike O'hare

External Collaborators

Publications

    2014

    • Georgiou M, Choi D, Li D, Mason C, Raisman G, Jat P, Wall I (2014). IMPROVING YIELD AND EXPANSION OF PRIMARY OLFACTORY ENSHEATHING CELLS TO GENERATE STABLE CELL LINES FOR SPINAL CORD INJURY. WOUND REPAIR AND REGENERATION, 22(5), A81 - A81.
    • Brown CA, Schmidt C, Poulter M, Hummerich H, Kloehn P-C, Jat P, Mead S, Collinge J, Lloyd SE (2014). In vitro screen of prion disease susceptibility genes using the scrapie cell assay. HUMAN MOLECULAR GENETICS, 23(19), 5102 - 5108. doi:10.1093/hmg/ddu233
    • Mirabile I, Jat PS, Brandner S, Collinge J (2014). Identification of clinical target areas in the brainstem of prion infected mice.. Neuropathol Appl Neurobiol, , - . doi:10.1111/nan.12189
    • Iannetti A, Ledoux AC, Tudhope SJ, Sellier H, Zhao B, Mowla S, Moore A, Hummerich H, Gewurz BE, Cockell SJ, Jat PS, Willmore E, Perkins ND (2014). Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence.. PLoS Genet, 10(9), e1004642 - . doi:10.1371/journal.pgen.1004642
    • Segedy AK, Pyle AL, Li B, Zhang Y, Babaev VR, Jat P, Fazio S, Atkinson JB, Linton MF, Young PP (2014). Identification of Small Proline-Rich Repeat Protein 3 as a Novel Atheroprotective Factor That Promotes Adaptive Akt Signaling in Vascular Smooth Muscle Cells.. Arterioscler Thromb Vasc Biol, , - . doi:10.1161/ATVBAHA.114.303644
    • Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan H-M, Cai Y, Bloom GS, Jat P, Collinge J, Kloehn P-C (2014). Cellular prion replication is controlled by expression of extracellular matrix proteins. PRION, 8, 21 - 21.
    • Mowla SN, Lam EW, Jat PS (2014). Cellular senescence and aging: the role of B-MYB.. Aging Cell, , - . doi:10.1111/acel.12242
    • Brown CA, Schmidt C, Poulter M, Hummerich H, Klöhn PC, Jat P, Mead S, Collinge J, Lloyd SE (2014). In-vitro screen of prion disease susceptibility genes using the scrapie cell assay.. Hum Mol Genet, , - . doi:10.1093/hmg/ddu233
    • Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan HM, Cai Y, Bloom GS, Jat P, Collinge J, Klöhn PC (2014). Identification of a gene regulatory network associated with prion replication.. EMBO J, , - . doi:10.15252/embj.201387150

    2013

    • Zhou Y, Hu Y, Yang M, Jat P, Li K, Lombardo Y, Xiong D, Coombes RC, Raguz S, Yagüe E (2013). The miR-106b∼25 cluster promotes bypass of doxorubicin-induced senescence and increase in motility and invasion by targeting the E-cadherin transcriptional activator EP300.. Cell Death Differ, , - . doi:10.1038/cdd.2013.167
    • Mowla SN, Perkins ND, Jat PS (2013). Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence.. Onco Targets Ther, 6, 1221 - 1229. doi:10.2147/OTT.S36160
    • Guhr SS, Sachs M, Wegner A, Becker JU, Meyer TN, Kietzmann L, Schlossarek S, Carrier L, Braig M, Jat PS, Stahl RA, Meyer-Schwesinger C (2013). The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation.. Kidney Int, 84(3), 532 - 544. doi:10.1038/ki.2013.115
    • Caballero OL, Cohen T, Gurung S, Chua R, Lee P, Chen YT, Jat P, Simpson AJ (2013). Effects of CT-Xp gene knock down in melanoma cell lines.. Oncotarget, 4(4), 531 - 541.
    • Gorvin CM, Wilmer MJ, Piret SE, Harding B, van den Heuvel LP, Wrong O, Jat PS, Lippiat JD, Levtchenko EN, Thakker RV (2013). Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients.. Proc Natl Acad Sci U S A, 110(17), 7014 - 7019. doi:10.1073/pnas.1302063110

    2011

    • Vaughan S, Jat PS (2011). Deciphering the role of nuclear factor-κB in cellular senescence.. Aging (Albany NY), 3(10), 913 - 919.
    • Rovillain E, Mansfield L, Lord CJ, Ashworth A, Jat PS (2011). An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence.. BMC Genomics, 12, 355 - . doi:10.1186/1471-2164-12-355
    • Rovillain E, Mansfield L, Caetano C, Alvarez-Fernandez M, Caballero OL, Medema RH, Hummerich H, Jat PS (2011). Activation of nuclear factor-kappa B signalling promotes cellular senescence.. Oncogene, 30(20), 2356 - 2366. doi:10.1038/onc.2010.611
    • Goold R, Rabbanian S, Sutton L, Andre R, Arora P, Moonga J, Clarke AR, Schiavo G, Jat P, Collinge J, Tabrizi SJ (2011). Rapid cell-surface prion protein conversion revealed using a novel cell system. NAT COMMUN, 2, - . doi:10.1038/ncomms1282

    2010

    • Jia M, Souchelnytskyi N, Hellman U, O'Hare M, Jat PS, Souchelnytskyi S (2010). Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancer. PROTEOM CLIN APPL, 4(10-11), 816 - 828. doi:10.1002/prca.201000006
    • Alexopoulou AN, Leao M, Caballero OL, Da Silva L, Reid L, Lakhani SR, Simpson AJ, Marshall JF, Neville AM, Jat PS (2010). Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines.. Breast Cancer Res, 12(4), R51 - . doi:10.1186/bcr2610
    • Sakairi T, Abe Y, Kajiyama H, Bartlett LD, Howard LV, Jat PS, Kopp JB (2010). Conditionally immortalized human podocyte cell lines established from urine.. Am J Physiol Renal Physiol, 298(3), F557 - F567. doi:10.1152/ajprenal.00509.2009
    • Sakairi T, Abe Y, Jat PS, Kopp JB (2010). Cell-cell contact regulates gene expression in CDK4-transformed mouse podocytes.. Am J Physiol Renal Physiol, 299(4), F802 - F809. doi:10.1152/ajprenal.00205.2010

    2009

    • Docquier F, Kita GX, Farrar D, Jat P, O'Hare M, Chernukhin I, Gretton S, Mandal A, Alldridge L, Klenova E (2009). Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation.. Clin Cancer Res, 15(18), 5762 - 5771. doi:10.1158/1078-0432.CCR-09-0329
    • Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat PS, Roberts TM, Gjoerup OV (2009). Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.. J Virol, 83(1), 117 - 127. doi:10.1128/JVI.01515-08
    • Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW (2009). PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons.
    • Grigoriadis A, Oliver GR, Tanney A, Kendrick H, Smalley MJ, Jat P, Neville AM (2009). Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues.. BMC Genomics, 10, 324 - . doi:10.1186/1471-2164-10-324

    2008

    • Jefferies HB, Cooke FT, Jat P, Boucheron C, Koizumi T, Hayakawa M, Kaizawa H, Ohishi T, Workman P, Waterfield MD, Parker PJ (2008). A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.. EMBO Rep, 9(2), 164 - 170. doi:10.1038/sj.embor.7401155
    • Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW (2008). PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.. PLoS One, 3(6), e2455 - . doi:10.1371/journal.pone.0002455

    2007

    • Yagüe E, Arance A, Kubitza L, O'Hare M, Jat P, Ogilvie CM, Hart IR, Higgins CF, Raguz S (2007). Ability to acquire drug resistance arises early during the tumorigenesis process.. Cancer Res, 67(3), 1130 - 1137. doi:10.1158/0008-5472.CAN-06-2574
    • Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM (2007). Surveillance mechanism linking Bub1 loss to the p53 pathway.. Proc Natl Acad Sci U S A, 104(20), 8334 - 8339. doi:10.1073/pnas.0703164104
    • Lock RL, Szeto TH, Entwistle A, Gjoerup OV, Jat PS (2007). Preparation of monoclonal antibodies against the spindle checkpoint kinase Bub1.. Hybridoma (Larchmt), 26(3), 140 - 147. doi:10.1089/hyb.2007.003
    • Jat P (2007). MAbs 2B8, 13G9, and 17E9 against mouse Bub1 protein. HYBRIDOMA, 26(3), 190 - 190. doi:10.1089/hyb.2007.9982

    2006

    • Grigoriadis A, MacKay A, Reis-Filho JS, Steele D, Iseli C, Stevenson BJ, Jongeneel CV, Valgeirsson H, Fenwick K, Iravani M, Leao M, Simpson AJG, Strausberg RL, Jat PS, Ashworth A, Neville AM, O'Hare MJ (2006). Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data. Breast Cancer Research, 8(5), R56 - . doi:10.1186/bcr1604
    • Wood-Kaczmar A, Gandhi S, Jat P, Miljan EA, Sinden J, Keen GJ, Taylor J, Latchman DS, Wood NW, Tabrizi SJ (2006). Generation of a cellular model of PINK1 parkinsonism in primary human dopaminergic neurons.
    • Grønning LM, Tingsabadh R, Hardy K, Dalen KT, Jat PS, Gnudi L, Shepherd PR (2006). Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway.. Am J Physiol Endocrinol Metab, 290(4), E599 - E606. doi:10.1152/ajpendo.00242.2005
    • Gandhi S, Wood-Kaczmar A, Jat P, Latchman DS, Tabrizi SJ, Wood NW (2006). Investigation of PINK1 dysfunction in Parkinson's disease.
    • Jia M, Souchelnytskyi N, Hellman U, Jat P, O'Hare MJ, Souchelnytskyi S (2006). Proteome profiling of conditionally immortalized human breast epithelial cells. MOL CELL PROTEOMICS, 5(10), S267 - S267.
    • Kawata S, Suzuki J, Maruoka M, Mizutamari M, Ishida-Kitagawa N, Yogo K, Jat PS, Shishido T (2006). Retrovirus-mediated conditional immortalization and analysis of established cell lines of osteoclast precursor cells.. Biochem Biophys Res Commun, 350(1), 97 - 104. doi:10.1016/j.bbrc.2006.09.020
    • Lopez-Garcia J, Periyasamy M, Thomas RS, Christian M, Leao M, Jat P, Kindle KB, Heery DM, Parker MG, Buluwela L, Kamalati T, Ali S (2006). ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.. Nucleic Acids Res, 34(21), 6126 - 6136. doi:10.1093/nar/gkl875

    2005

    • Hardy K, Mansfield L, MacKay A, Benvenuti S, Ismail S, Arora P, O'Hare MJ, Jat PS (2005). Transcriptional networks and cellular senescence in human mammary fibroblasts. Molecular Biology of the Cell, 16(2), 943 - 953.

    2004

    • Tarunina M, Alger L, Chu G, Munger K, Gudkov A, Jat PS (2004). Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival.. Molecular and Cellular Biology, 24(24), 10792 - 10801. doi:10.1128/MCB.24.24.10792-10801.2004
    • Cotsiki M, Lock RL, Cheng Y, Williams GL, Zhao J, Perera D, Freire R, Entwistle A, Golemis EA, Roberts TM, Jat PS, Gjoerup OV (2004). Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proceedings of the National Academy of Sciences of the United States of America, 101(4), 947 - 952. doi:10.1073/pnas.0308006100
    • Fauth C, O'Hare MJ, Lederer G, Jat PS, Speicher MR (2004). Order of genetic events is critical determinant of aberrations in chromosome count and structure. Genes, Chromosomes and Cancer, 40(4), 298 - 306.
    • Suzuki J, Sukezane T, Akagi T, Georgescu MM, Ohtani M, Inoue H, Jat PS, Goff SP, Hanafusa H, Shishido T (2004). Loss of c-abl facilitates anchorage-independent growth of p53- and RB- deficient primary mouse embryonic fibroblasts.. Oncogene, 23(52), 8527 - 8534. doi:10.1038/sj.onc.1207894
    • Lock RL, Benvenuti S, Jat PS (2004). Immortalisation by SV40 large T antigen.. In Stein GS, Pardee AB (Ed.), Cell cycle and growth control: biological regulation and cancer (pp. 467 - ). : Wiley-Blackwell. doi:10.1002/0471656437

    2003

    • Mackay A, Jones C, Dexter T, Silva RL, Bulmer K, Jones A, Simpson P, Harris RA, Jat PS, Neville AM, Reis LF, Lakhani SR, O'Hare MJ (2003). cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells.. Oncogene, 22(17), 2680 - 2688.

    2002

    • Benvenuti S, Cramer R, Bruce J, Waterfield MD, Jat PS (2002). Identification of novel candidates for replicative senescence by functional proteomics. ONCOGENE, 21(28), 4403 - 4413. doi:10.1038/sj.onc.1205525
    • Lidington EA, Rao RM, Marelli-Berg FM, Jat PS, Haskard DO, Mason JC (2002). Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2K(b)-tsA58 mice. AM J PHYSIOL-CELL PH, 282(1), C67 - C74.
    • Benvenuti S, Cramer R, Quinn CC, Bruce J, Zvelebil MJ, Corless S, Bond J, Yang A, Hockfield S, Burlingame AL, Waterfield MD, Jat PS (2002). Differential proteome analysis of replicative senescence in rat embryo fibroblasts.. Molecular and Cellular Proteomics, 1(4), 280 - 292. doi:10.1074/mcp.M100028-MCP200
    • Djelloul S, Tarunina M, Barnouin K, Mackay A, Jat PS (2002). Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescence.. doi:10.1038/sj.onc.1205253

    2001

    • Mason JC, Lidington EA, Rao RM, Marelli-Berg FM, Jat PS, Haskard DO (2001). Use of H-2Kb-tsA58 transgenic mice to generate conditionally immortalized, growth factor responsive mouse cardiac endothelial cells for in vitro studies. FASEB J, 15(5), A947 - A947.
    • Lidington EA, Rao RM, Marelli-Berg F, Jat P, Haskard DO, Mason JC (2001). Isolation and characterisation of conditionally immortal growth factor responsive cardiac endothelial cells (EC) from H-2K(b)-tsA58 transgenic mice. RHEUMATOLOGY, 40, 8 - 8.
    • O'Hare M, Bond J, Clarke C, Takeuchi Y, Atherton AJ, Berry C, Moody J, Silver ARJ, Davies DC, Alsop AE, Neville AM, Jat PS (2001). Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells.. Proceedings of the National Academy of Sciences of the United States of America, 98(2), 646 - 651. doi:10.1073/pnas.98.2.646
    • Darmon AJ, Jat PS (2001). Immortalisation of primary rodent cells by SV40. In (Ed.), (pp. 7 - 41). : .

    2000

    • John HA, Laffling AJ, Marrs J, Baird A, Jat PS, Holdstock NB, Rossdale PD (2000). Establishment and characterization of equine autonomic ganglion cell lines to enable direct testing of candidate toxins involved in equine dysautonomia (grass sickness). Cell Biology and Toxicology, 16(1), 63 - 74.
    • Sinden JD, Pilcher HR, Mann VM, Kershaw TR, Dong Z, Rodriguez T, Barnetson A, Majumdar S, Weeratunga N, Price J, Jat PS (2000). Human neural stem cells: A comparison of genetic and epigenetic approaches to long-term culturing. EUR J NEUROSCI, 12, 245 - 245.
    • Lidington EA, Rao RM, Marelli-Berg F, Jat P, Haskard DO, Mason JC (2000). Establishment and characterisation of a conditionally transformed immortalised murine cardiac endothelial cell line isolated from H2kb-tsA58 transgenic mice.. CIRCULATION, 102(18), 329 - 329.
    • Darmon AJ, Jat PS (2000). BAP37 and Prohibitin are specifically recognized by an SV40 T antigen antibody.. Mol Cell Biol Res Commun, 4(4), 219 - 223. doi:10.1006/mcbr.2001.0281

    1999

    • Powell AJ, Darmon AJ, Gonos ES, Lam EW, Peden KW, Jat PS (1999). Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen. Oncogene, 18(51), 7343 - 7350.

    1998

    • Gonos ES, Derventzi A, Kveiborg M, Agiostratidou G, Kassem M, Clark BFC, Jat PS, Rattan SIS (1998). Cloning and identification of genes that associate with mammalian replicative senescence. Experimental Cell Research, 240, 66 - 74.
    • Hugnot JP, Jat P, Sinden J (1998). Characterisation of telencephalon E10 cell cultures. EUR J NEUROSCI, 10, 8 - 8.
    • Powell AJ, Gates PB, Wylie D, Velloso CP, Brockes JP, Jat PS (1998). Immortalization of rat embryo fibroblasts by a 3'-untranslated region.. Exp Cell Res, 240(2), 252 - 262. doi:10.1006/excr.1998.3937

    1996

    • Hopfer U, Jacobberger JW, Gruenert DC, Eckert RL, Jat PS, Whitsett JA (1996). Immortalization of epithelial cells.. Am J Physiol, 270(1 Pt 1), C1 - 11.
    • Gonos ES, Burns JS, Mazars GR, Kobrna A, Riley TE, Barnett SC, Zafarana G, Ludwig RL, Ikram Z, Powell AJ, Jat PS (1996). Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation.. Mol Cell Biol, 16(9), 5127 - 5138.

    1995

    • Noble M, Groves AK, Ataliotis P, Ikram Z, Jat PS (1995). The H-2KbtsA58 transgenic mouse as a single source of a wide range of conditionally immortal cell lines. In Monastersky GM, Robl JM (Ed.), Strategies in transgenic animal science (pp. 325 - ). : Amer Society for Microbiology.
    • Noble M, Groves AK, Ataliotis P, Ikram Z, Jat PS (1995). The H-2KbtsA58 transgenic mouse: a new tool for the rapid generation of novel cell lines.. Transgenic Res, 4(4), 215 - 225.
    • Woolf AS, Kolatsi-Joannou M, Hardman P, Andermarcher E, Moorby C, Fine LG, Jat PS, Noble MD, Gherardi E (1995). Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros.. J Cell Biol, 128(1-2), 171 - 184.
    • Ehler E, Jat PS, Noble MD, Citi S, Draeger A (1995). Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties.. Circulation, 92(11), 3289 - 3296.
    • MAZARS GR, POWELL A, BURNS J, KOBRNA A, JAT P (1995). REGULATION OF THE EXPRESSION OF THE CDK INHIBITOR P21 IN SENESCENCE OF RAT EMBRYO FIBROBLASTS. J CELL BIOCHEM, , 70 - 70.

    1994

    • DRAEGER A, EHLER E, JAT PS, NOBLE MD (1994). SEARCHING FOR PRECURSOR CELLS OF THE VASCULAR WALL. J MUSCLE RES CELL M, 15(2), 214 - 214.
    • LANDELS EC, PROSCHEL C, NOBLE MD, JAT PS, FINE LG, WOOLF AS (1994). RECEPTOR TYROSINE KINASES (RTKS) EXPRESSED IN EARLY NEPHROGENESIS. J AM SOC NEPHROL, 5(3), 721 - 721.
    • PARTRIDGE T, MORGAN J, PAGEL C, BEAUCHAMP J, PECKHAM M, NOBLE M, JAT P (1994). MYOGENIC CELLS WITH STEM-CELL PROPERTIES. J CELL BIOCHEM, , 266 - 266.
    • Morgan JE, Beauchamp JR, Pagel CN, Peckham M, Ataliotis P, Jat PS, Noble MD, Farmer K, Partridge TA (1994). Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: a model system for the derivation of tissue-specific and mutation-specific cell lines.. Dev Biol, 162(2), 486 - 498. doi:10.1006/dbio.1994.1103
    • Ikram Z, Norton T, Jat PS (1994). The biological clock that measures the mitotic life-span of mouse embryo fibroblasts continues to function in the presence of simian virus 40 large tumor antigen.. Proc Natl Acad Sci U S A, 91(14), 6448 - 6452.
    • Eibl RH, Kleihues P, Jat PS, Wiestler OD (1994). A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen.. Am J Pathol, 144(3), 556 - 564.

    1993

    • Chambers TJ, Owens JM, Hattersley G, Jat PS, Noble MD (1993). Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse.. Proc Natl Acad Sci U S A, 90(12), 5578 - 5582.
    • Noble M, Groves AK, Ataliotis P, Morgan J, Peckham M, Partridge T, Jat PS (1993). Biological and molecular approaches to the generation of conditionally immortal neural cells.. Neuroprotocols, 3(3), 189 - 199.
    • Groves AK, Entwistle A, Jat PS, Noble M (1993). The characterization of astrocyte cell lines that display properties of glial scar tissue.. Dev Biol, 159(1), 87 - 104. doi:10.1006/dbio.1993.1223
    • Whitehead RH, VanEeden PE, Noble MD, Ataliotis P, Jat PS (1993). Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice.. Proc Natl Acad Sci U S A, 90(2), 587 - 591.

    1992

    • GONOS ES, POWELL AJ, JAT PS (1992). HUMAN AND RODENT FIBROBLASTS - MODEL SYSTEMS FOR STUDYING SENESCENCE AND IMMORTALIZATION (REVIEW). INT J ONCOL, 1(2), 209 - 213.
    • HATTERSLEY G, OWENS JM, JAT PS, NOBLE MD, CHAMBERS TJ (1992). GENERATION OF CELL-LINES WITH POTENT ABILITY TO FORM BONE RESORBING OSTEOCLASTS. J BONE MINER RES, 7, S112 - S112.
    • Noble M, Groves AK, Ataliotis P, Jat PS (1992). From chance to choice in the generation of neural cell lines.. Brain Pathol, 2(1), 39 - 46.
    • Gonos ES, Powell AJ, Ikram Z, Cline M, Jat PS (1992). A molecular genetic approach towards senescence and immortalization. In Spandidos DA (Ed.), Current Perspectives on Molecular and Cellular Oncology: Volume 1 (Part A) Mechanisms of Gene Regulation in Cancer (pp. - ). : Elsevier Science Ltd.
    • Cline MJ, Jat PS, Foti A (1992). Molecular mechanisms in the evolution of chronic myelocytic leukemia.. Leuk Lymphoma, 7(4), 283 - 287. doi:10.3109/10428199209049779

    1991

    • NOBLE M, ATALIOTIS P, BARNETT SC, BEVAN K, BOGLER O, GROVES A, JAT P, WOLSWIJK G, WREN D (1991). DEVELOPMENT, REGENERATION, AND NEOPLASIA OF GLIAL-CELLS IN THE CENTRAL-NERVOUS-SYSTEM. ANN NY ACAD SCI, 633, 35 - 47.
    • Ahuja HG, Jat PS, Foti A, Bar-Eli M, Cline MJ (1991). Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia.. Blood, 78(12), 3259 - 3268.
    • Groves AK, Bögler O, Jat PS, Noble M (1991). The cellular measurement of time.. Curr Opin Cell Biol, 3(2), 224 - 229.
    • Jat PS, Noble MD, Ataliotis P, Tanaka Y, Yannoutsos N, Larsen L, Kioussis D (1991). Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse.. Proc Natl Acad Sci U S A, 88(12), 5096 - 5100.
    • Larsson L, Timms E, Blight K, Restall DE, Jat PS, Fisher AG (1991). Characterization of murine thymic stromal-cell lines immortalized by temperature-sensitive simian virus 40 large T or adenovirus 5 E1a.. Dev Immunol, 1(4), 279 - 293.
    • Venter DJ, Bevan KL, Ludwig RL, Riley TE, Jat PS, Thomas DG, Noble MD (1991). Retinoblastoma gene deletions in human glioblastomas.. Oncogene, 6(3), 445 - 448.

    1990

    • Riley TE, Follin A, Jones NC, Jat PS (1990). Maintenance of cellular proliferation by adenovirus early region 1A in fibroblasts conditionally immortalized by using simian virus 40 large T antigen requires conserved region 1.. Mol Cell Biol, 10(12), 6664 - 6673.

    1989

    • Schnipper LE, Chan V, Sedivy J, Jat P, Sharp PA (1989). Gene activation by induced DNA rearrangements.. Cancer Res, 49(23), 6640 - 6644.
    • Vousden KH, Jat PS (1989). Functional similarity between HPV16E7, SV40 large T and adenovirus E1a proteins.. Oncogene, 4(2), 153 - 158.
    • Jat PS, Sharp PA (1989). Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature.. Mol Cell Biol, 9(4), 1672 - 1681.

    1988

    • McKay R, Frederiksen K, Jat PS, Levy D (1988). Reconstructing the brain from immortal cell lines. In (Ed.), Progress in Brain Research (pp. 647 - 649). : Elsevier BV. doi:10.1016/S0079-6123(08)60344-1
    • FREDERIKSEN K, JAT PS, VALTZ N, LEVY D, MCKAY R (1988). IMMORTALIZATION OF PRECURSOR CELLS FROM THE MAMMALIAN CNS. NEURON, 1(6), 439 - 448.
    • Weinberger J, Jat PS, Sharp PA (1988). Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.. Mol Cell Biol, 8(2), 988 - 992.

    1986

    • JAT PS, CEPKO CL, MULLIGAN RC, SHARP PA (1986). RECOMBINANT RETROVIRUSES ENCODING SIMIAN-VIRUS 40 LARGE T-ANTIGEN AND POLYOMAVIRUS LARGE AND MIDDLE T-ANTIGENS. MOL CELL BIOL, 6(4), 1204 - 1217.
    • JAT PS, SHARP PA (1986). LARGE T-ANTIGENS OF SIMIAN VIRUS-40 AND POLYOMAVIRUS EFFICIENTLY ESTABLISH PRIMARY FIBROBLASTS. J VIROL, 59(3), 746 - 750.

    1982

    • JAT P, ARRAND JR (1982). INVITRO TRANSCRIPTION OF 2 EPSTEIN-BARR VIRUS SPECIFIED SMALL RNA MOLECULES. NUCLEIC ACIDS RES, 10(11), 3407 - 3425.
    • Kamen R, Jat P, Treisman R, Favaloro J, Folk WR (1982). 5' termini of polyoma virus early region transcripts synthesized in vivo by wild-type virus and viable deletion mutants.. J Mol Biol, 159(2), 189 - 224.
    • COWIE A, JAT P, KAMEN R (1982). DETERMINATION OF SEQUENCES AT THE CAPPED 5' ENDS OF POLYOMA-VIRUS EARLY REGION TRANSCRIPTS SYNTHESIZED INVIVO AND INVITRO DEMONSTRATES AN UNUSUAL MICROHETEROGENEITY. J MOL BIOL, 159(2), 225 - 255.
    • Jat P, Novak U, Cowie A, Tyndall C, Kamen R (1982). DNA sequences required for specific and efficient initiation of transcription at the polyoma virus early promoter.. Mol Cell Biol, 2(7), 737 - 751.
    • Jat P, Roberts JW, Cowie A, Kamen R (1982). Comparison of the polyoma virus early and late promoters by transcription in vitro.. Nucleic Acids Res, 10(3), 871 - 887.

    1981

    • Grosveld GC, Shewmaker CK, Jat P, Flavell RA (1981). Localization of DNA sequences necessary for transcription of the rabbit beta-globin gene in vitro.. Cell, 25(1), 215 - 226.
    • JAT P, TREISMAN R, FAVALORA J, KAMEN R (1981). THE 5'-ENDS OF POLYOMA-VIRUS EARLY REGION TRANSCRIPTS SYNTHESIZED INVIVO AND INVITRO - COMPARISONS OF WILD-TYPE AND DELETION MUTANT TEMPLATES. MOL BIOL REP, 7(1-3), 180 - 180.
    • Treisman R, Cowie A, Favaloro J, Jat P, Kamen R (1981). The structures of the spliced mRNAs encoding polyoma virus early region proteins.. J Mol Appl Genet, 1(2), 83 - 92.