Dr Peter Brett

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Personal Profile

Name: Peter Brett Email: peter.brett@ucl.ac.uk
Title: Dr Tel: 020 7915 1104
Department: Biomaterials & Tissue Eng Fax:
Position: Senior Lecturer Address: UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD
Research Domain: Basic Life Sciences, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

Dr Brett's research interests fall into two broad areas Genetics of complex diseases and Genomics. The work into the genetic susceptibility to periodontal diseases is producing some world leading results implicating gene polymorphisms in the IL-6 gene with susceptibility to both Localised Aggressive and Chronic periodontal diseases, we have shown the association between IL-6 genotypes and the susceptibility to develop periodontal disease in both Caucasians and a rural Indian population; the presence of pathogenic bacteria in the mouth; the severity of symptoms; and the association of systemic serum levels of IL-6 in response to inflammatory stimuli; also the restoration of arterial elasticity after periodontal therapy reducing the systemic levels of IL-6. I also have collaborations with Manchester and Leeds Universities investigating the aetiology of Papillon-Lefèvre Syndrome, a syndrome that causes a very aggressive early onset form of periodontal disease.

The genomic work revolves around osteoblast and stromal cell interactions on titanium implant surfaces. Dr Brett has developed a research programme examining, both in vivo (with Prof. Donos) and in vitro, bone and stromal cell interactions to titanium implant surfaces. We have used microarrays (Affymetrix) for expression profiling work to examine cell interaction at a molecular level in both in vivo and in vitro models. Dr Brett has strong collaborative links with Institut Straumann AG (CH)a major manufacturer of implants. Further to this work an interesting phenomenon has been discovered on the selection of osteogenic stem cells from the heterogeneous population of adult stem cells resident in bone marrow. This phenomenon lends itself to the selection of osteogenic stem cells from a variety of tissues (blood; adipose; bone marrow etc) for expansion in bioreactors for use in regenerative/repair procedures for bone defects or even the coating of implants for enhanced osseointegration. I am currently seeking collaborators/funding for the development of this area.

Research Activities

Genetic susceptibility to Periodontal Disease and the molecular basis of implant osseointegration

Single cell adhesion on Ti and related implant materials

Education Description

UCL Collaborators

Dr Laurent Bozec

External Collaborators

Publications

    2014

    • Logan N, Sherif A, Cross AJ, Collins SN, Traynor A, Bozec L, Parkin IP, Brett P (2014). TiO2 coated CoCrMo; Improving the osteogenic differentiation and adhesion of mesenchymal stem cells in vitro.. J Biomed Mater Res A, , - . doi:10.1002/jbm.a.35264

    2013

    • Gellynck K, Shah R, Parkar M, Young A, Buxton P, Brett P (2013). Small molecule stimulation enhances bone regeneration but not titanium implant osseointegration. Bone, (0), - . doi:10.1016/j.bone.2013.09.012

    2012

    • Nibali L, Brett PM, Donos N, Griffiths GS (2012). Hereditary gingival hyperplasia associated with amelogenesis imperfecta: a case report.. Quintessence Int, 43(6), 483 - 489.
    • Khan MR, Salih V, Brett PM, Donos N (2012). The enhanced modulation of key bone matrix components by modified Titanium implant surfaces. Bone, 50(1), 1 - 8. doi:10.1016/j.bone.2011.07.040
    • Khan MR, Donos N, Salih V, Brett PM (2012). The enhanced modulation of key bone matrix components by modified Titanium implant surfaces.. Bone, 50(1), 1 - 8. doi:10.1016/j.bone.2011.07.040

    2011

    • Nibali L, Madden I, Franch Chillida F, Heitz-Mayfield L, Brett P, Donos N (2011). IL6 -174 genotype associated with Aggregatibacter actinomycetemcomitans in Indians.. Oral Dis, 17(2), 232 - 237. doi:10.1111/j.1601-0825.2010.01731.x

    2010

    • Franch-Chillida F, Nibali L, Madden IM, Donos N, Brett PM (2010). Association between interleukin-6 polymorphisms and periodontitis in Indian non-smokers. Journal of Clinical Periodontology, 37(2), 137 - 144.

    2009

    • Nibali L, Donos N, Ready D, Pratten J, Parkar MH, Brett PM, D'Aiuto F (2009). IL6 polymorphisms are associated with A. actinomycetemcomitans: patient- and site-based results.
    • Rapp G, McQuillin A, Brett PM, Tonetti MS, Donos N (2009). Evidence of linkage on 1022-23.2 to periodontitis in Brazilian families.
    • Carlqvist K, Brett PM, Lewis MP (2009). A novel and rapid isolate method of human muscle derived subpopulations. European Cells and Materials, 18(SUPPL. 2), 24 - 24.
    • Nibali L, D'Aiuto F, Donos N, Griffiths GS, Parkar MH, Tonetti MS, Humphries SE, Brett PM (2009). Association between periodontitis and common variants in the promoter of the interleukin-6 gene. Cytokine, 45(1), 50 - 54.
    • Meade JL, Wilson EB, Holmes TD, de Wynter EA, Brett PM, Straszynski L, Ballard PAS, Trapani JA, McDermott MF, Cook GP (2009). Proteolytic activation of the cytotoxic phenotype during human NK cell development. The Journal of Immunology, 183(2), 803 - 813.
    • Wall I, Donos N, Carlqvist K, Jones F, Brett P (2009). Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone, 45(1), 17 - 26. doi:10.1016/j.bone.2009.03.662

    2008

    • Carlqvist K, Brett PM, Lewis MP (2008). Craniofacial MDPCs could be used in clinical bone regeneration applications.
    • Nibali L, Tonetti MS, Ready D, Parkar MH, Brett PM, Donos N, D'Aiuto F (2008). Interleukin-6 polymorphisms are associated with pathogenic bacteria in subjects with peridontitis. Journal of Periodontology, 79(4), 677 - 683.
    • Nibali L, Griffiths GS, Donos N, Parkar MH, D'Aiuto F, Tonetti MS, Brett PM (2008). Association between interleukin-6 promoter haplotypes and aggressive periodontitis. Journal of Clinical Periodontology, 35(3), 193 - 198.
    • Nibali L, Donos N, Ready D, Parkar MH, Brett PM, D'Aiuto F (2008). Clinical and genetic factors as predictors for presence of periodontopathogens.
    • Nibali L, Donos N, Brett PM, Parkar MH, Ellinas T, Llorente M, Griffiths GS (2008). A familial analysis of aggressive periodontitis - clinical and genetic findings. Journal of Periodontal Research, 43(6), 627 - 634.
    • Nibali L, Parkar MH, D'Aiuto F, Suvan JE, Brett PM, Griffiths GS, Rosin M, Schwahn C, Tonetti MS (2008). Vitamin D receptor polymorphism (-1056 Taq-1) interacts with smoking for the presence and progression of periodontitis. Journal of Clinical Periodontology, 35(7), 561 - 567.

    2007

    • D'Aiuto F, Smith A, Parkar MH, Nibali L, Brett PM, Tonetti MS, Humphries S, Donos N (2007). Interleukin-6 gene polymorphisms influence systemic inflammatory response following periodontal therapy.
    • Nibali L, Donos N, Parkar MH, D'Aiuto F, Tonetti MS, Griffiths GS, Brett PM (2007). Association between interleukin-6 haplotypes and aggressive periodontitis.
    • Franch-Chillida F, Nibali L, Madden IM, Newman HN, Donos N, Brett PM (2007). Association between IL-6 polymorphisms and periodontitis in an Indian population.
    • Donos N, Retzepi M, Wall I, Brett PM, Ivanovski S (2007). Effect of implant surface in early stages of bone healing.
    • Wall I, Donos N, Brett PM (2007). Titanium surface modifications promote osteogenic responses of human MSC cultures.
    • Nibali L, Ready D, Parkar MH, Brett PM, Wilson M, Tonetti MS, Griffiths GS (2007). Gene polymorphisms and the prevalence of key periodontal pathogens. Journal of Dental Research, 86(5), 416 - 420.
    • Brett PM, Ivanovski S, Harle J, Tonetti MS, Donos N, Wall I (2007). Investigation of the differentiation potential of periodontal tissues.

    2006

    • Harle J, Wall I, Ivanovski S, Jones FH, Brett PM (2006). Titanium ion-implantation effects in human osteoblast cells.
    • Meade JL, de Wynter EA, Brett PM, Sharif SM, Woods CG, Markham AF, Cook GP (2006). A family with Papillon-Lefèvre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity. Blood, 107(9), 3665 - 3668. doi:10.1182/blood-2005-03-1140
    • Nibali L, Parkar MH, Brett PM, Knight J, Tonetti MS, Griffiths GS (2006). NADPH oxidase (CYBA) and FcγR polymorphisms as risk factors for aggressive periodontitis. A case-control association study. Journal of Clinical Periodontology, 33(8), 529 - 539. doi:10.1111/j.1600-051X.2006.00952.x
    • Wall I, Harle J, Ivanovski S, Jones FH, Brett PM (2006). Functional and genomic responses of osteoblasts to titanium implant roughness.

    2005

    • Meade JL, de Wynter EA, Brett P, Sharif SM, Woods G, Markham AF, Cook GP (2005). A family with Papillon-Lefevre syndrome (PLS) reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity.
    • Brett PM, Zygogianni P, Griffiths GS, Tomaz M, Parkar MH, D'Aiuto F, Tonetti MS (2005). Functional gene polymorphisms in aggressive and chronic periodontitis. Journal of Dental Research, 84(12), 1149 - 1153.

    2004

    • Curtis D, Brett P, Dearlove AM, McQuillin A, Kalsi G, Robertson MM, Gurling HM (2004). Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13. Psychiatr Genet, 14, 83 - 87.
    • D'Aiuto F, Parkar MH, Brett PM, Ready D, Tonetti MS (2004). Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections. Cytokine, 28(1), 29 - 34. doi:10.1016/j.cyto.2004.06.005
    • Harle J, Salih V, Olsen I, Brett PM, Jones FH, Tonetti MS (2004). Gene expression profiling of bone cells on smooth and rough titanium surfaces. Journal of Materials Science: Materials in Medicine, 15(11), 1255 - 1258.
    • Harle J, Salih V, Olsen I, Jones FH, Tonetti MS, Brett PM (2004). Analysis of bone cell responses to titanium surface roughness.
    • Hewitt C, McCormick D, Linden G, Turk D, Stern I, Wallace I, Southern L, Zhang L, Howard R, Bullon P, Wong M, Widmer R, Gaffar KA, Awawdeh L, Briggs J, Yaghmai R, Jabs EW, Hoeger P, Bleck O, R diger SG, Petersilka G, Battino M, Brett PM, Hattab F, Al-Hamed M, Sloan P, Toomes C, Dixon M, James J, Read AP, Thakker N (2004). The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis. Human Mutation, 23(3), 222 - 228. doi:10.1002/humu.10314
    • Brett PM, Harle J, Salih V, Olsen I, Jones FH, Tonetti MS (2004). The axl genes in osteoblast response to titanium in vitro.
    • Brett PM, Harle J, Salih V, Mihoc R, Olsen I, Jones FH, Tonetti MS (2004). Roughness response genes in osteoblasts. Bone, 35(1), 124 - 133. doi:10.1016/j.bone.2004.03.009
    • D'Aiuto F, Parkar MH, Andreou G, Suvan JE, Brett PM, Ready D, Tonetti MS (2004). Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. Journal of Dental Research, 83(2), 156 - 160.
    • D'Aiuto F, Parkar MH, Andreaou G, Brett PM, Ready D, Tonetti MS (2004). Periodontitis and atherogenesis: causal association or simple coincidence? A pilot intervention study. Journal of Clinical Periodontology, 31(5), 402 - 411.

    2003

    • Madden IM, Brett PM, Olsen I, Bidinger PD (2003). Tissue collection using cytology brushes for DNA profiling in periodontitis.
    • Brett PM, Zygogianni P, Tomaz M, Griffiths GS, Tonetti MS (2003). An association of aggressive periodontitis with the IL-1 gene cluster.
    • Brett PM, Zygogianni P, Griffiths GS, Tonetti MS (2003). Differential genotyping in periodontitis.
    • Brett P, Zygogianni P, Tomaz M, Griffiths G, Tonetti M (2003). An association of aggressive periodontitis with the IL-1 gene cluster..
    • Madden IM, Brett PM, Olsen I, Bidinger PD (2003). Tissue collection using cytology brushes for dna profiling in periodontitis..
    • Zygogianni P, Brett PM, Tomaz M, Griffiths GS, Tonetti MS (2003). Vitamin-D receptor, TNF-a gene polymorphisms and aggressive periodontitis.
    • Zygogianni P, Brett P, Tomaz M, Griffiths G, Tonetti M (2003). Vitamin-D receptor, TNF-a gene polymorphisms and aggressive periodontitis.

    2002

    • Brett PM, Parkar MH, Olsen I, Tonetti MS (2002). Expression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: a model for tissue regeneration. Journal of Dental Research, 81(11), 776 - 783.
    • D'Aiuto F, Andreou G, Suvan JE, Brett PM, Patel K, Darbar UR, Laurell L, Griffiths GS, Wilson M, Tonetti MS (2002). Does non-surgical periodontal therapy change serum acute-phase proteins?. doi:10.1902/annals.2002.7.1.112
    • Parkar MH, Brett PM, Olsen I, Tonetti MS (2002). Gene expression in PDL cells treated with Emdogain: analysis using cDNA arrays.
    • D 'Aiuto F, Andreou G, Suvan JE, Patel K, Darbar UR, Laurell L, Griffiths GS, Tonetti MS (2002). Does non-surgical periodontal therapy decrease serum c-reactive protein (CRP)?. doi:10.1902/jop.2002.73.11.1396
    • Brett PM, Salih V, Olsen I, Tonetti M (2002). Effects of titanium surfaces on osteoblast gene expression profiles.. J DENT RES, 81, A233 - A233.
    • Brett PM, Salih V, Olsen I, Tonetti MS (2002). Effects of titanium surfaces on osteoblast gene expression profiles.
    • Parkar MH, Brett PM, Olsen I, Tonetti M (2002). Gene expression in PDL cells treated with Emdogain: Analysis using cDNA arrays.. J DENT RES, 81, A152 - A152.

    2001

    • Brett PM, Parkar MH, Olsen I, Tonetti MS (2001). Expressional profiling of primary PDL cells stimulated by Emdogain.

    2000

    • Morris M-A, Yiannakou JY, King AL, Brett PM, Biagi F, Vaughan R, Curtis D, Ciclitira PJ (2000). Coeliac disease and Down syndrome: associations not due to genetic linkage on chromosome 21. Scandinavian Journal of Gastroenterology, 35(2), 177 - 180.
    • King AL, Yiannakou JY, Brett PM, Curtis D, Morris MA, Dearlove AM, Rhodes M, Rosen-Bronson S, Mathew C, Ellis HJ, Ciclitira PJ (2000). A genome-wide family-based linkage study of coeliac disease. Annals of Human Genetics, 64(6), 479 - 490.

    1999

    • Brett PM, Yiannakou JY, Morris MA, Vaughan R, Curtis D, Ciclitira PJ (1999). Common HLA alleles, rather than rare mutants, confer susceptibility to coeliac disease. Annals of Human Genetics, 63, 217 - 225.
    • Warren V, Brett P, Macdonald AS, Plumb RHR, A P (1999). Genetic tests and future need for long-term care in the UK: report of a Work Group of the Continuing Care Conference Genetic Tests and Long-term Care Study Group..
    • Brett P (1999). An electronic companion to genetics. ADDICT BIOL, 4(3), 362 - 362.
    • Yiannakou JY, Brett PM, Morris MA, Curtis D, Mathew C, Vaughan R, RosenBronson S, Ciclitira PJ (1999). Family linkage study of the T-cell receptor genes in coeliac disease. Italian Journal of Gastroenterology and Hepatology, 31(3), 198 - 201.

    1998

    • Brett PM, Yiannakou JY, Morris MA, Bronson SR, Mathew C, Curtis D, Ciclitira PJ (1998). A pedigree-based linkage study of coeliac disease: failure to replicate previous positive findings. Annals of Human Genetics, 62(1), 25 - 32.

    1997

    • McQuillin A, Murray KD, Etheridge CJ, Stewart L, Cooper RG, Brett PM, Miller AD, Gurling HM (1997). Optimization of liposome mediated transfection of a neuronal cell line. Neuroreport, 8, 1481 - 1484.
    • Brett PM, Curtis D, Robertson MM, Gurling HM (1997). Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome. Biol Psychiatry, 42, 941 - 947. doi:10.1016/S0006-3223(97)00140-6

    1996

    • Brett PM, Yasuda N, Yiannakou JY, Herbst F, Ellis HJ, Vaughan R, Nicholls RJ, Ciclitira PJ (1996). Genetic and immunological markers in pouchitis. European Journal of Gastroenterology and Hepatology, 8(10), 951 - 955.
    • Cook CCH, Palsson G, Turner A, Holmes D, Brett P, Curtis D, Petursson H, Gurling HMD (1996). A genetic linkage study of the D-2 dopamine receptor locus in heavy drinking and alcoholism. BRIT J PSYCHIAT, 169(2), 243 - 248.
    • Brett PM, Curtis D, Robertson MM, Dahlitz M, Gurling HM (1996). Linkage analysis and exclusion of regions of chromosomes 3 and 8 in Gilles de la Tourette syndrome following the identification of a balanced reciprocal translocation 46 XY, t(3:8)(p21.3 q24.1) in a case of Tourette syndrome. Psychiatr Genet, 6, 99 - 105.
    • Cook CC, Palsson G, Turner A, Holmes D, Brett P, Curtis D, Petursson H, Gurling HM (1996). A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism. Br J Psychiatry, 169, 243 - 248.

    1995

    • Brett PM, Curtis D, Robertson MM, Gurling HM (1995). The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase. Biol Psychiatry, 37, 533 - 540. doi:10.1016/0006-3223(94)00161-U
    • Brett PM, Curtis D, Robertson MM, Gurling HM (1995). Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior. Am J Psychiatry, 152, 437 - 440.

    1994

    • Brett PM, Le Bourdelles B, See CG, Whiting PJ, Attwood J, Woodward K, Robertson MM, Kalsi G, Povey S, Gurling HM (1994). Genomic cloning and localization by FISH and linkage analysis of the human gene encoding the primary subunit NMDAR1 (GRIN1) of the NMDA receptor channel. Ann Hum Genet, 58, 95 - 100.

    1993

    • Curtis D, Sherrington R, Brett PM, Holmes DS, Kalsi G, Brynjolfsson J, Petursson H, Rifkin L, Murphy P, Moloney E, Melmer G, Gurling HMD (1993). Genetic linkage analysis of manic depression in Iceland. Journal of the Royal Society of Medicine, 86(9), 506 - 510.
    • Brett PM, Melmer G, Robertson MM, Gurling HM (1993). A microsatellite polymorphism at the THRB locus.
    • Curtis D, Brynjolfsson J, Petursson H, Holmes S, Sherrington R, Brett PM, Rifkin L, Murphy P, Moloney E, Melmer G, Gurling HMD (1993). Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A). Annals of Human Genetics, 57(1), 27 - 39.
    • Brett P, Robertson M, Gurling H, Curtis D (1993). Failure to find linkage and increased homozygosity for the dopamine D3 receptor gene in Tourette's syndrome.

    1991

    • Brett PM, Melmer G, Gurling HM (1991). A microsatellite polymorphism at the D3S11 locus.
    • Melmer G, Brynjolfsson J, Curtis D, Holmes D, Brett PM, Rifkin L, Murphy P, Sherrington R, Petursson H, Gurling H (1991). Report of current progress in linkage analysis of manic depression in Iceland and at University College and Middlesex School of Medicine.
    • Holmes D, Brynjolfsson J, Brett P, Curtis D, Petursson H, Sherrington R, Gurling H (1991). No evidence for a susceptibility locus predisposing to manic depression in the region of the dopamine (D2) receptor gene. Br J Psychiatry, 158, 635 - 641.
    • HOLMES D, BRYNJOLFSSON J, BRETT P, CURTIS D, PETURSSON H, SHERRINGTON R, GURLING H (1991). NO EVIDENCE FOR A SUSCEPTIBILITY LOCUS PREDISPOSING TO MANIC-DEPRESSION IN THE REGION OF THE DOPAMINE (D2) RECEPTOR GENE. BRIT J PSYCHIAT, 158, 635 - 641.
    • Brett PM, Curtis D, Melmer G, Sherrington R, Holmes D, Robertson M, Gurling H (1991). Linkage analysis in a large pedigree multiply affected with Gilles de la Tourette syndrome.

    1990

    • Brett P, Curtis D, Gourdie A, Schnieden V, Jackson G, Holmes D, Robertson M, Gurling H (1990). Possible linkage of Tourette syndrome to markers on short arm of chromosome 3 (C3p21-14).

    1989

    • Brett PM, Robertson M, Sherrington RP, Holmes D, Dahlitz M, Gurling HMD (1989). Linkage analysis of Gilles de la Tourette syndrome (GTS) in a large British pedigree.

    • Brett PM (). The control of mesenchymal stromal cell osteogenic differentiation through modified surfaces. , , - .
    • Nibali L, Tonetti MS, Ready D, Parkar M, Brett PM, DonosN , D AF (). Interleukin-6 polymorphisms are associated with pathogenic bacteria in periodontitis patients. Journal of Periodontology, , - .
    • Nibali L, D'Aiuto F, Donos N, Griffiths G, Parkar M, Tonetti M, Humphries S, Brett P (). Association between periodontitis and common Variants in the promoter of the Interleukin-6 gene Corresponding Author. Cytokine, , - .
    • Nibali L, Griffiths GS, Parkar M, D AF, Tonetti MS, Donos N, Brett PM (). Association between Interleukin-6 haplotypes and aggressive Periodontitis. Journal of Clinical Periodontology, , - .