Dr Paul Winyard

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Personal Profile

Name: Paul Winyard Email: p.winyard@ucl.ac.uk
Title: Dr Tel: 020 7905 2116
Department: ICH - Nephro-Urology Unit Fax: 020 7905 2133
Position: Clinical Reader Address: Nephro-Urology Unit, UCL Institute of Child Health, London, WC1N 1EH
Research Domain: Basic Life Sciences, Personalised Medicine, Populations & Lifelong Health Web Page:  

Profile

Research Description

My research interests follow three major strands:

1. Normal and dysplastic human renal precursor cells. I have generated a panel of normal and abnormal human cell lines from human fetal and postnatal dysplastic kidneys with which to investigate key processes in vitro. These stem-like cells are unique, and no-one else in the world has been able to generate comparable human lines. Capacity to promote normal differentiation in vitro, raises the possibility of using these cells as therapies in vivo. I have established several international collaborations to further exploit these cells.

 2. Galectin-3 in cystic kidneys. Polycystic kidney disease (PKD) is common in humans and, despite many trials, there are no firmly established therapies that prevent progression to kidney failure. I demonstrated that lack of galectin-3 promotes cystogenesis (Chiu et al. Am J Path, 2006), suggesting that this lectin may be a natural brake on cyst formation. I am currently investigating galectin-3 therapy in several models of autosomal recessive polycystic kidney disease. Novel therapies arising from this study may be applicable to humans with PKD in future. Intriguingly, pectin, a natural inhibitor of galectin-3 found in many fruits appears protective in experimental renal disease (Kolatsi-Joannou et al, 2011); hence, galectin-3 may have differing effects in the kidney depending on disease and localisation.

3. My clinical research (and practice) centres on children with kidney malformations, particularly those that present before birth. I work with Professor Lyn Chitty (Fetal Medicine and Genetics) and Mr Divyesh Desai (Paediatric Urology) in the Fetal Nephro-Urology clinic at UCLH to investigate kidney/urinary tract malformations. We are collecting amniotic fluid to identify prognostic markers from mid pregnancy. Proteomic analysis has identified several markers that look promising and we hope to collect more samples in the next year to confirm these results. Our aim is to develop prognostic kits for use in routine clinical practice.


Research Activities

Cystic kidney diseases

Biology of renal and urinary tract malformations,

Blood vessels and the kidney

Congential Disorders of Glycosylation

Kidney development

Normal and abnormal kidney and renal tract development

Renal progenitor (stem) cells

Thymosin-beta4 in the healthy and diseased glomerulus

Education Description

I have a long-standing commitment to improving education and teaching of Paediatricians and related specialists, particularly by developing new opportunities for academic careers. I am committed to increasing quality of teaching with increased flexibility and initiated the BSc in Paediatrics which is unique in the UK.

Current roles

Director iBSc in Paediatrics and Child Health, UCL ICH

Director MSc in Paediatrics and Child Health, UCL ICH

Academic Programme Director, London Speciality School of Paediatrics

Paediatric Academic CSAC, Royal College of Paediatrics and Child Health

Previous major roles

Director of Teaching and Learning at ICH

Programme author and director: Paediatric Academic Clinical Fellows and Lecturers ICH/UCL

Director visiting fellows programme - ICH/GOS

Director student and elective attachments - GOS

Author of education and teaching strategy for first ICH/GOS BRC

Founder of the Otto Wolff lecture series - ICH/GOS

Pioneer automated lecture capture system - ICH

 

UCL Collaborators

Prof Peter Scambler; Dr Kevin Mills; Prof Simon Heales; Dr Mike Hubank; Prof Therese Hesketh; Dr David Long; Prof Philip Beales; Dr Philippa Mills; Prof Adrian Woolf; Prof Justin Hsuan; Dr Lesley Rees

External Collaborators

Publications

    2013

    • Hudson LD, Cumby C, Klaber RE, Nicholls DE, Winyard PJ, Viner RM (2013). Low levels of knowledge on the assessment of underweight in children and adolescents among middle-grade doctors in England and Wales.. Arch Dis Child, 98(4), 309 - 311. doi:10.1136/archdischild-2012-303357
    • Brown CC, Apps JR, Winyard PJ (2013). A new generation of academic paediatricians.. Lancet, 382(9886), 28 - . doi:10.1016/S0140-6736(13)61527-5

    2012

    • Harteneck C, Weber S, Buescher A, Riehle M, Hoyer P, Jeruschke S, Kolatsie M, Nagel M, Winyard P, Gollasch M (2012). Mutations in TRPC6 ion channels in patients suffering from familial focal segmental glomerolusclerosis.
    • Brockschmidt A, Chung B, Weber S, Fischer DC, Kolatsi-Joannou M, Christ L, Heimbach A, Shtiza D, Klaus G, Simonetti GD, Konrad M, Winyard P, Haffner D, Schaefer F, Weber RG (2012). CHD1L: a new candidate gene for congenital anomalies of the kidneys and urinary tract (CAKUT).. Nephrol Dial Transplant, 27(6), 2355 - 2364. doi:10.1093/ndt/gfr649

    2011

    • Renkema KY, Winyard PJ, Skovorodkin IN, Levtchenko E, Hindryckx A, Jeanpierre C, Weber S, Salomon R, Antignac C, Vainio S, Schedl A, Schaefer F, Knoers NV, Bongers EM, EUCAKUT consortium (2011). Novel perspectives for investigating congenital anomalies of the kidney and urinary tract (CAKUT).. Nephrol Dial Transplant, 26(12), 3843 - 3851. doi:10.1093/ndt/gfr655
    • Winyard P, Jenkins D (2011). Putative roles of cilia in polycystic kidney disease.. Biochim Biophys Acta, 1812(10), 1256 - 1262. doi:10.1016/j.bbadis.2011.04.012
    • Winyard PJD, Jenkins D (2011). Putative roles of cilia in polycystic kidney disease.
    • Kolatsi-Joannou M, Price KL, Winyard PJ, Long DA (2011). Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury.. PLoS One, 6(4), e18683 - . doi:10.1371/journal.pone.0018683
    • Morgenstern D, Hasan F, Gibson S, Winyard P, Sebire N, Anderson J (2011). PAX5 expression in non haematopoietic tissues; reappraisal of previous studie.. American Journal of Clinical Pathology, , - .

    2010

    • Chan SK, Riley PR, Price KL, McElduff F, Winyard PJ, Welham SJ, Woolf AS, Long DA (2010). Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog. American Journal of Physiology - Renal Physiology, 298, F346 - F356. doi:10.1152/ajprenal.00574.2009
    • Winyard P (2010). FETAL HYDRONEPHROSIS - SHOULD WE DO A POST NATAL WORK UP OR NOT?. CHILD CARE HEALTH AND DEVELOPMENT, 36, 25 - 25.
    • Morgenstern DA, Hasan F, Gibson S, Winyard P, Sebire NJ, Anderson J (2010). PAX5 Expression in Nonhematopoietic Tissues. AM J CLIN PATHOL, 133(3), 407 - 415. doi:10.1309/AJCPZPQNOLUGKMME

    2009

    • Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Winyard PJ, Cansick J, Bingham C, Edghill EL, Shroff RC, Stanescu H, Ryffel G, Ellard S, Woolf AS (2009). hepatocyte nuclear factor 1 beta mutations are associated with hypomagnesaemia and renal magnesium wasting.
    • Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Winyard PJ, Cansick J, Bingham C, Edghill EL, Shroff RC, Stanescu H, Ryffel G, Ellard S, Woolf AS (2009). Hepatocyte Nuclear Factor 1B mutations are associated with hypomagnesemia and renal magnesium wasting. Pediatric Nephrology, 24(4), 885 - 885.
    • Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van 'tHoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Cansick J, Mushtaq I, Dhillon HK, Bingham C, Edghill EL, Shroff R, Stanescu H, Ryffel GU, Ellard S, Bockenhauer D (2009). HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. Journal of the American Society of Nephrology, 20(5), 1123 - 1131.
    • Hothi DK, Wade AS, Gilbert R, Winyard PJ (2009). Mild Fetal Renal Pelvis Dilatation--Much Ado About Nothing?. Clinical Journal of the American Society of Nephrology, 4(1), 168 - 177.
    • Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Winyard PJ, Cansick J, Bingham C, Edghill EL, Shroff RC, Stanescu H, Ryffel G, Ellard S, Woolf AS (2009). Hepatocyte Nuclear Factor 1B mutations are associated with hypomagnesemia and renal magnesium wasting. PEDIATR NEPHROL, 24(4), 885 - 885.

    2008

    • Adalat S, Woolf AS, Ledermann SE, Van'T Hoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Dhillon H, Cansick J, Rees L, Bockenhauer D (2008). Hepatocyte nuclear factor 1 beta mutations commonly cause hypomagnesemia. PEDIATR NEPHROL, 23(9), 1654 - 1654.
    • Winyard P, Chitty LS (2008). Dysplastic kidneys. Semin Fetal Neonatal Med, 13(3), 142 - 151.
    • Weber S, Taylor JC, Winyard P, Baker KF, Sullivan-Brown J, Schild R, Knuppel T, Zurowska AM, Caldas-Alfonso A, Litwin M, Emre S, Ghiggeri GM, Bakkaloglu A, Mehls O, Antignac C, Network E, Schaefer F, Burdine RD (2008). SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development. J Am Soc Nephrol, 19(5), 891 - 903.
    • Wang D, Heywood W, Mills K, Winyard PJD, Chitty LS (2008). Identification of novel protein biomarkers in amnaiotic fluid and fetal urine in fetuses with serious renal abnormalities..

    2007

    • Winyard P, Chitty LS (2007). Dysplastic kidneys. Semin.Fetal Neonatal Med., , - .
    • Jenkins D, Winyard PJ, Woolf AS (2007). Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. Journal of Anatomy, 211(5), 620 - 629.
    • Weber S, Taylor J, Winyard PJD, Baker KF, Schild R, Knuppel T, Zurowska AM, Caldas-Alfonso AC, Litwin M, Emre S, Ghiggeri GM, Bakkaloglu A, Mehls O, Antignac C, ESCAPE Study Group , Schaefer F, Burdine RD (2007). Mutations in SIX2 and BMP4 are associated with anomlous development of the kidney in humans and zebafish. J Am Soc Nephrol, , - .
    • Barratt TM, Ledermann SE, Roy S, Rees L, Goonaskera CG, Dillon MJ, Nash M, van't Hoff W, Feather SA, Winyard PJD, de Bruyn R, Marks SD (2007). Renal Diseases. In Strobel S, Spitz L, Marks S, El Habbal M (Ed.), The Great Ormond Street Colour Handbook of Paediatrics and Child Health (pp. 297 - 311). : Manson Publishing.
    • Winyard PJD (2007). Human Renal Development: In vivo insights from In vitro studies.
    • Liapis H, Winyard P (2007). Cystic diseases and Developmental kidney defects. In Jennette JC, Olson JL, Schwartz MM, Silva FG (Ed.), Heptinstall's pathology of the kidney (pp. 1257 - 1306). : Lippincott Williams and Wilkins.
    • Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ (2007). Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Physiological Genomics, 28(2), 193 - 202.

    2006

    • Whitten SM, Stojilkovic-Mikic T, Winyard PJ, Chitty LS (2006). OP02. 33: Outcome of prenatally diagnosed echogenic kidneys.
    • Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ (2006). Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Physiol Genomics, , - .
    • Winyard PJ, Cass HD, Stephenson TJ, Wilkinson AR, Olver RE (2006). Developing critical mass and growing our own academics. Archives of Disease Childhood, 91(12), 1027 - 1029.
    • Winyard PJ, Cass HD, Stephenson TJ, Wilkinson AR, Olver RE (2006). Developing critical mass and growing our own academics.. Arch Dis Child, 91(12), 1027 - 1029. doi:10.1136/adc.2006.105502
    • Chiu MG, Johnson TM, Woolf AS, hm-Vicker EM, Long DA, Guay-Woodford L, Hillman KA, Bawumia S, Venner K, Hughes RC, Poirier F, Winyard PJ (2006). Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. American Journal of Pathology, 169(6), 1925 - 1938. doi:10.2353/ajpath.2006.060245
    • Dolan V, Alarcon P, Ruddle P, Gerrelli D, Woolf AS, Winyard P, Hensey C (2006). Gremlin, a bone morphogenetic protein antagonist essential for pronephric development, is expressed in normal human renal development and multicystic renal dysplasia. Scottish Medical Journal, 51(1), 55 - 55.
    • Marks SD, Winyard PJD (2006). Pediatric nephrology. In Godbole P, Gearhart JP, Wilcox DT (Ed.), Clinical Problems in Pediatric Urology (pp. 1 - 8). : Blackwell Publishing Limited.
    • Winyard PJ, Bharucha T, De BR, Dillon MJ, van't HW, Trompeter RS, Liesner R, Wade A, Rees L (2006). Perinatal renal venous thrombosis: presenting renal length predicts outcome. Archives of Disease in Childhood - Fetal and Neonatal Edition, 91(4), F273 - F278.

    2005

    • Jenkins D, Bitner-Glindzicz M, Malcolm S, Hu CCA, Allison J, Winyard PJD, Gullett AM, Thomas DFM, Belk RA, Feather SA, Sun TT, Woolf AS (2005). De novo UPIIIa mutations cause human urinary tract malformations which lead to severe renal failure.
    • Jenkins D, Bitner-Glindzicz M, Malcolm S, Hu CCA, Allison J, Winyard PJD, Gullett AM, Thomas DFM, Belk RA, Feather SA, Sun TT, Woolf AS (2005). De Novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure. Journal of the American Society of Nephrology, 16(7), 2141 - 2149. doi:10.1681/ASN.2004090776

    2004

    • Dolan V, Ruddle P, Gerrelli D, Woolf AS, Hensey C, Winyard PJD (2004). Gremlin, a BMP antagonist, is expressed in human renal development and multicystic renal dysplasia.
    • Gonzalez-Martinez D, Kim SH, Hu Y, Guimond S, Schofield J, Winyard P, Vannelli GB, Turnbull J, Bouloux PM (2004). Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism. Journal of Neuroscience, 24(46), 10384 - 10392. doi:10.1523/JNEUROSCI.3400-04.2004
    • Chiu MG, Woolf AS, Johnson TM, Hillman KA, Hughes RC, Poirier F, Guay-Woodford L, Winyard PJD (2004). Galectin-3 retards the progression of polycystic kidney disease and localises to the primary cilium.
    • Woolf AS, Price KL, Scambler PJ, Winyard PJ (2004). Evolving concepts in human renal dysplasia. Journal of the American Society of Nephrology, 15(4), 998 - 1007.
    • Chiu MG, Johnson TM, Woolf AS, Hillman KA, Bawumia S, Hughes RC, Poirier F, Guay-Woodford LM, Winyard PJD (2004). "Galectin-3 retards the development of autosomal recessive polycystic kidney disease and localises to the primary cilium".
    • Romio L, Fry AM, Winyard PJD, Malcolm S, Woolf AS, Feather SA (2004). OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis. doi:10.1097/01.ASN.0000140220.46477.SC
    • Parkes HG, Kidane JE, Chitty L, Tse Y, Winyard PJ (2004). NMR studies of amniotic fluid in human fetal urogenital tract obstruction.
    • Winyard PJD (2004). Structure and development of the human kidney. In Flinter F, Maher E, Saggar-Malik A (Ed.), The Genetics of Renal Disease (pp. - ). : Oxford University Press.
    • Gonzalez-Martinez D, Winyard P, Woolf AS, Bouloux PM (2004). GnRH, anosmin-1 and FGFR1 immunoreactivity in the developing human brain.
    • Hillman KA, Woolf AS, Johnson TM, Wade A, Unwin RJ, Winyard PJD (2004). The P2X(7) ATP receptor modulates renal cyst development in vitro. Biochem.Biophys.Res.Commun., 322(2), 434 - 439.
    • Hillman KA, Woolf AS, Johnson TM, Wade A, Unwin RJ, Winyard PJ (2004). The P2X7 ATP receptor modulates renal cyst development in vitro. Biochemical and Biophysical Research Communications, 322(2), 434 - 439.
    • Jenkins D, Hu CC, Allison J, Gullett AM, Winyard PJ, Malcolm S, Feather S, Sun TT, Bitner-Glindzicz M, Woolf AS (2004). "De novo mutations in UPIIIA cause severe bilateral renal dysplasia".
    • Romio L, Fry AM, Winyard PJ, Malcolm S, Woolf AS, Feather SA (2004). OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis. Journal of the American Society of Nephrology, 15(10), 2556 - 2568. doi:10.1097/01.ASN.0000140220.46477.5C
    • Romio L, Fry AM, Winyard PJ, Malcolm S, Woolf AS, Feather SA (2004). OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis.. J Am Soc Nephrol, 15(10), 2556 - 2568. doi:10.1097/01.ASN.0000140220.46477.5C

    2003

    • Winyard PJ, Woolf AS, Price KL (2003). LIF signalling in human renal development..
    • Romio L, Wright V, Price K, Winyard PJ, Donnai D, Porteous ME, Franco B, Giorgio G, Malcolm S, Woolf AS, Feather SA (2003). OFD1, the gene mutated in Oral-Facial-Digital syndrome type 1, Is expressed in the metanephros and in human embryonic renal mesenchymal cells. J Am Soc Nephrol, 14(3), 680 - 689.
    • Hillman KA, Unwin RJ, Woolf AS, Winyard PJ (2003). P2X7 signalling is a modifier of epithelial lumen formation..
    • Romio L, Wright V, Price K, Winyard PJ, Donnai D, Porteous ME, Franco B, Giorgio G, Malcolm S, Woolf AS, Feather SA (2003). OFD1, the gene mutated in oral-facial-digital syndrome type 1, is expressed in the metanephros and in human embryonic renal mesenchymal cells. Journal of the American Society of Nephrology, 14(3), 680 - 689.
    • Mulroy S, Boucher C, Winyard PJD, Sandford R (2003). Cystic Renal Disease. In Vize PD, Woolf AS, Bard JBL (Ed.), The Kidney (pp. - ). : Academic Press.
    • Winyard PJD, Woolf AS, Price K (2003). LIF signaling in human renal development..
    • Hillman KA, Unwin RJ, Woolf AS, Winyard PJD (2003). P2X7 signaling Is a modifier of epithelial lumen formation.
    • Woolf AS, Welham SJM, Hermann MM, Winyard PJD (2003). Maldevelopment of the human kidney and lower urinary tract: an overview.. In Vize PD, Woolf AS, Bard JBL (Ed.), The Kidney: from Normal Development to Congenital Disease (pp. 377 - 393). : Amsterdam, Elsevier Science/Academic Press.

    2002

    • Hillman KA, Johnson TM, Winyard PJ, Burnstock G, Unwin RJ, Woolf AS (2002). P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Exp.Nephrol., 10(1), 34 - 42.
    • Hillman KA, Johnson TM, Winyard PJ, Burnstock G, Unwin RJ, Woolf AS (2002). P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Experimental Nephrology, 10(1), 34 - 42.
    • Woolf AS, Winyard PJ (2002). Molecular mechanisms of human embryogenesis: developmental pathogenesis of renal tract malformations. Pediatr Dev Pathol, 5(2), 108 - 129.
    • Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJ, Peebles DM, Woolf AS, Cuckow PM (2002). Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation. The Journal of Urology, 168(4), 1615 - 1620.
    • Hillman KA, Johnson TM, Unwin RJ, Woolf AS, Winyard PJ (2002). The P2X7 ATP receptor modulates renal cyst morphogenesis.. J AM SOC NEPHROL, 13, 115A - 115A.
    • Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJD, Peebles DM, Woolf AS, Cuckow PM (2002). Fetal sheep bladder outflow obstruction perturbs detrusor contractility, volume-pressure relationships and innervation. The Journal of Urology, 168, 1615 - 1620.
    • Hillman KA, Johnson TM, Unwin RJ, Woolf AS, Winyard PJD (2002). The P2X7 ATP receptor modulates renal cyst morphogenesis.
    • Price K, Woolf AS, Winyard PJD (2002). Human dysplastic kidney mesenchyme cells generate a perturbed milieu of HGF and GDNF, classical ureteric bud morphogens.
    • Johnson TM, Hughes RC, Poirier F, Woolf AS, Winyard PJD (2002). Galectin-3 is overexpressed in collecting duct cysts in cpk/cpk mice and downregulated by Taxol in vivo and in vitro. American Society of Nephrology.
    • Romio L, Wright V, Reynolds K, Winyard PJD, Malcolm S, Woolf AS, Feather SA (2002). The protein mutated in the oral-facial-digital syndrome type 1 is a metanephric mesenchymal factor.. J AM SOC NEPHROL, 13, 18A - 18A.
    • Romio L, Wright V, Price K, Winyard PJD, Malcolm S, Woolf AS, Feather SA (2002). The Oral-facial-digital syndrome type 1 gene codes for human metanphric mesenchimal protein..

    2001

    • Deeb A, Robertson A, McColl G, Bouloux PMG, Winyard PJD, Woolf AS, Moghal NE, Cheetham TD (2001). X linked Kallmann Syndrome and multicystic dysplastic kidney - a new association.. Nephrol Dial Transplant, 16(6), 1170 - 1175.
    • Yang SP, Woolf AS, Quinn F, Winyard PJD (2001). Deregulation of renal transforming growth factor beta 1 after experimental short-term ureteric obstruction in fetal sheep. American Journal of Pathology, 159(1), 109 - 117.
    • Cuckow PM, Nyirady P, Winyard PJD (2001). Normal and abnormal development of the urogenital tract. Prenatal Diagnosis, 21(11), 908 - 916.
    • Bullock SL, Johnson TM, Bao Q, Hughes RC, Winyard PJ, Woolf AS (2001). Galectin-3 modulates ureteric bud branching in organ culture of the developing mouse kidney. Journal of the American Society of Nephrology, 12(3), 515 - 523.
    • Johnson TM, Woolf AS, Poirier F, Hughes RC, Winyard PJD (2001). Galectin-3 is upregulated in cpk/cpk mouse polycystic kidney disease and decreased epithelial expression correlates with reduced cyst growth in vivo and in vitro following paclitaxel therapy. J Am Soc Nephrol, 12, 537A - .
    • Deeb A, Robertson A, MacColl G, Bouloux PM, Gibson M, Winyard PJ, Woolf AS, Moghal NE, Cheetham TD (2001). Multicystic dysplastic kidney and Kallmann\'s syndrome: a new association?. Nephrology Dialysis Transplantation, 16(6), 1170 - 1175.
    • Yang SP, Woolf AS, Quinn F, Winyard PJD (2001). Deregulation of renal transforming growth factor-1 after experimental short-term ureteric obstruction in fetal sheep.
    • Nyirady P, Thiruchevlan N, Fry CH, Peebles DH, Godley ML, Winyard PJD, Woolf AS, Rodeck CH, Cuckow PH (2001). PUV in an animal model - electromechanical properties of detrusor smooth muscle. doi:10.1046/j.1464-410X.2001.0880s1001.x
    • Winyard P, Chitty L (2001). Dysplastic and polycystic kidneys: diagnosis, associations and management. Prenat Diagn, 21(11), 924 - 935.

    2000

    • Woolf AS, Winyard PJ (2000). Gene expression and cell turnover in human renal dysplasia. Histol Histopathol., 15(1), 159 - 166.
    • Winyard PJD, Sidwell R (2000). Renal. In Sidwell R, Thompson M (Ed.), Concise Paediatrics (pp. 211 - 246). : Greenwich Medical Media.
    • Nishizawa S, Peters J, Cuckow PM, Winyard PJD (2000). Congenital kidney and bladder malformations in the T(2;11)30H mouse.
    • Nishizawa S, Peters J, Cuckow PM, Winyard PJD (2000). Congenital kidney and bladder malformations in the T(2;11)30H mouse. UK Renal Association, London, April 2000, , - .
    • Yang SP, Woolf AS, Yuan HT, Scott RJ, Risdon RA, O'Hare MJ, Winyard PJ (2000). Potential biological role of transforming growth factor beta 1 in human congenital kidney malformations. American Journal of Pathology, 157(5), 1633 - 1647.
    • Cale CM, Klein NJ, Winyard PJ, Woolf AS (2000). Inflammatory mediators in human renal dysplasia. Nephrology Dialysis Transplantation, 15(2), 173 - 183.
    • Yang SP, Woolf AS, Yuan HT, Scott RJ, Risdon RA, O'Hare MJ, Winyard PJD (2000). Biological role of transforming growth factor 1 in human congenital kidney malformations.

    1999

    • Ascham H, Koleros D, Winyard PJD, Quinn F, Hanson MA, Woolf A.S. (1999). Brief fetal urinary flow impairment causes metanephric transdifferentiation to smooth muscle lineage. Journal of the American Society of Nephrology, 10, 402 - .
    • Winyard PJD, Liesner R, Trompeter RS, Rees LR (1999). Neonatal renal venous thrombosis - predisposing factors, management and outcome.
    • Shah NF, Smith VV, Malone M, Lindley KJ, Winyard P, Milla PJ (1999). Hypertrophic Eosinophilic Gastrenteropathy: Apoptotic failure in a new syndrome.
    • Attar R, Winyard PJD, Quinn F, Mouriquand PDE, Duffy P, Hanson MA, Foxall P, Woolf AS (1999). Biology of fetal glomerulocystic disease associated with ureteric obstruction..
    • Winyard PJD, Yang SP, Maric C, Scott R, Risdon R, O'Hare MJ, Woolf AS (1999). Aberrant expression of components of the renin-angiotensin system in human renal dysplasia.

    1998

    • Woolf AS, Winyard PJ (1998). Advances in the cell biology and genetics of human kidney malformations. J Am Soc Nephrol, 9(6), 1114 - 1125.
    • Winyard P, Chaudhry B, Cale C (1998). A new college, a new direction in academic paediatrics?. Arch Dis Child, 78(4), 399 - .
    • Attar R, Quinn F, Winyard PJD, Mouriquand PDE, Foxall P, Hanson MA, Woolf A (1998). Short term urinary flow impairment deregulates PAX 2 expression, proliferation and cell survival in fetal sheep kidneys. American Journal of Pathology, 152(5), 1225 - 1235.
    • Winyard PJD, Chaudhry B, Cale CM (1998). A new college, a new direction in academic paediatrics? [letter; comment]. Arch.Dis.Child, 78(4), 399 - .
    • Winyard PJD (1998). The Biology of Kidney Malformations, PhD Thesis.
    • Attar R, Quinn F, Winyard PJD, Mouriquand PDE, Foxall P, Hanson MA, Woolf AS (1998). Short-term urinary flow impairment deregulates PAX2 and PCNA expression and cell survival in fetal sheep kidneys. AM J PATHOL, 152(5), 1225 - 1235.

    1997

    • Chaudhry B, Winyard P, Cale C (1997). Academia: the view from below. BMJ (Clinical Research Ed.), 315(7108), 560 - 561.
    • Chaudhry B, Winyard P, Cale C (1997). Academia: the view from below [editorial] [see comments]. BMJ, 315(7108), 560 - 561.
    • Winyard PJD, Bao Q, Hughes RC, Woolf AS (1997). Apical galectin-3 in normal nephrogenesis and dysplastic renal epithelia.
    • Kolatsi-Joannou M, Moore R, Winyard PJ, Woolf AS (1997). Expression of hepatocyte growth factor/scatter factor and its receptor, MET, suggests roles in human embryonic organogenesis. Pediatric Research, 41(5), 657 - 665.
    • Feather SA, Winyard PJ, Dodd S, Woolf AS (1997). Oral-facial-digital syndrome type 1 is another dominant polycystic kidney disease: clinical, radiological and histopathological features of a new kindred. Nephrology Dialysis Transplantation, 12(7), 1354 - 1361.
    • Feather SA, Winyard PJD, Dodd S, Woolf AS (1997). Oral-facial-digital syndrome type I is another dominant polycystic kidney disease.. KIDNEY INT, 52(4), 1131 - 1131.
    • Winyard PJ, Bao Q, Hughes RC, Woolf AS (1997). Epithelial galectin-3 during human nephrogenesis and childhood cystic diseases. Journal of the American Society of Nephrology, 8(11), 1647 - 1657.

    1996

    • Winyard PJD, Feather SA (1996). Genetics of human kidney malformations.
    • Winyard PJ, Nauta J, Lirenman DS, Hardman P, Sams VR, Risdon RA, Woolf AS (1996). Deregulation of cell survival in cystic and dysplastic renal development. Kidney International, 49(1), 135 - 146.
    • Woolf AS, Bao Q, Hughes RC, Winyard PJD (1996). Galectin-3 in normal, polycystic and dysplastic nephrogenesis.
    • Winyard PJ, Risdon RA, Sams VR, Dressler GR, Woolf AS (1996). The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J Clin Invest, 98(2), 451 - 459.
    • Murch SH, Winyard PJ, Koletzko S, Wehner B, Cheema HA, Risdon RA, Phillips AD, Meadows N, Klein NJ, Walker-Smith JA (1996). Congenital enterocyte heparan sulphate deficiency with massive albumin loss, secretory diarrhoea, and malnutrition. The Lancet, 347(9011), 1299 - 1301.

    1995

    • Duke VM, Winyard PJ, Thorogood P, Soothill P, Bouloux PM, Woolf AS (1995). KAL, a gene mutated in Kallmann's syndrome, is expressed in the first trimester of human development. Molecular and Cellular Endocrinology, 110(1-2), 73 - 79.
    • Winyard PJD, Risdon RA, Woolf AS (1995). WT1 expression in the absence of bcl-2 may explain excessive apoptosis which occurs in human kidney malformations.
    • Woolf AS, Winyard PJ (1995). Unravelling the pathogenesis of cystic kidney diseases. Arch Dis Child, 72(2), 103 - 105.

    1994

    • WINYARD PJD, DUKE VM, THOROGOOD PV, NORMAN JT, BOULOUX PMG, WOOLF AS (1994). RENAL APLASIA (RA) IN KALLMANNS-SYNDROME (KS) MAY BE EXPLAINED BY KAL GENE-EXPRESSION DURING NEPHROGENESIS. J AM SOC NEPHROL, 5(3), 640 - 640.
    • Thornton PS, Alter CA, Katz LE, Gruccio DA, Winyard PJ, Moshang T, Jr (1994). The new highly sensitive adrenocorticotropin assay improves detection of patients with partial adrenocorticotropin deficiency in a short-term metyrapone test. Journal of Pediatric Endocrinology and Metabolism, 7(4), 317 - 324.
    • WINYARD PJD, LIRENMAN DS, RISDON RA, SAMS VR, WOOLF AS (1994). WIDESPREAD APOPTOSIS OCCURS IN HUMAN RENAL MALFORMATIONS AND CHILDHOOD POLYCYSTIC KIDNEY-DISEASE (P K D). J AM SOC NEPHROL, 5(3), 641 - 641.
    • Winyard PJD, Duke VM, Soothill P, Thorogood P, Bouloux PM, Woolf AS (1994). KAL gene expression during embryonic development explains the renal malformations in Kallmann's Syndrome.
    • Hardman P, Kolatsi M, Winyard PJ, Towers PR, Woolf AS (1994). Branching out with the ureteric bud. Exp Nephrol, 2(4), 211 - 219.

    1992

    • Winyard P, Thornton P, Grucio D, Moshang T (1992). Growth following treatment for head and neck sarcoma in children.