Dr Paul Winyard

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Personal Profile

Name: Paul Winyard Email: p.winyard@ucl.ac.uk
Title: Dr Tel: 020 7905 2116
Department: ICH Development Bio & Cancer Prog Fax: 020 7905 2133
Position: Clinical Reader Address: Nephrology Group, Developmental Biology and Cancer Programme, UCL Institute of Child Health, London, WC1N 1EH
Research Domain: Basic Life Sciences, Personalised Medicine, Populations & Lifelong Health Web Page:  

Profile

Research Description

My research has three main strands:

1. Normal and dysplastic human renal precursor cells. I have generated a panel of normal and abnormal human cell lines from human fetal and postnatal dysplastic kidneys with which to investigate key processes in vitro. These stem-like cells are unique, and no-one else in the world has been able to generate comparable human lines. Capacity to promote normal differentiation in vitro, raises the possibility of using these cells as therapies in vivo. I have established several international collaborations to further exploit these cells.

2. Treatment of polycystic kidneys. PKD is common in humans and, despite many trials, there are no firmly established therapies that prevent progression to kidney failure. I have previously worked on galectin-3, a likely natural brake on cystogenesis (Chiu et al. Am J Path, 2006), and we are assessing galectin-3 gene therapy in PKD. There may be several modes of action, however, since pectin (a natural inhibitor of galectin-3 found in many fruits) appears protective in experimental renal disease (Kolatsi-Joannou et al, 2011). My latest research, co-supervised with Dr David Long, has identified vascular growth factors and the microvasculature as functionally important in PKD (Huang - in revision). We have a patented new treatment and are again trialling it in models of PKD.

3. My clinical research (and practice) centres on children with kidney malformations, particularly those that present before birth. I work with Professor Lyn Chitty (Fetal Medicine and Genetics) and Mr Divyesh Desai (Paediatric Urology) in the Fetal Nephro-Urology clinic at UCLH to investigate kidney/urinary tract malformations. We are collecting amniotic fluid to identify prognostic markers from mid pregnancy. Proteomic analysis has identified several markers that look promising and we hope to collect more samples in the next year to confirm these results. Our aim is to develop prognostic kits for use in routine clinical practice.


Research Activities

Cystic kidney diseases

Biology of renal and urinary tract malformations,

Blood vessels and the kidney

Congential Disorders of Glycosylation

Kidney development

Normal and abnormal kidney and renal tract development

Renal progenitor (stem) cells

Thymosin-beta4 in the healthy and diseased glomerulus

Education Description

I am committed to developing and delivering high quality education. My focus is on Paediatrics, and I lead both the intercalated BSc and MSc in Paediatrics at the UCL Institute of Child Health. I believe that innovative, research-led courses generate the highest standards of teaching, learning and assessment. This is not rocket-science – it is just applying the same level of professionalism and excellence to education as UCL departments do to research.

I built the iBSc from scratch with Drs Elizabeth Carrey and Caroline Fertleman and we focused on novel assessments including reflective diaries and patient pathways rather than a traditional disease-centred approach. The course started in 2010 and has become the most successful iBSc in UCL Medical School with an applicant to places ratio of 3:1 and student satisfaction rating of 9.25/10. This success comes from listening to the students and continually refining modules and assessments, not just to improve standards but also aiming to generate well-rounded doctors who are advocates for children and young people. We work hard to develop bespoke projects that enthuse students, often in difficult areas such as child protection where there is little research base. Many projects have been presented nationally and changed practice via new clinical guidelines. All of our team are committed to quality; we have won many teaching awards across London Paediatrics and UCL, including the 2014 Provost's Teaching Award to our Fellow Benita Morrissey. Students now choose UCL because of our BSc. Perhaps we are producing better doctors too; it is early for definitive statistics but our first cohort just graduated medical school with twice as many distinctions and merits as before the BSc.

I have completely transformed the MSc, with Dr Helen Bedford, again responding to student feedback. Key changes include: increased flexibility and greater choice via new pathways such as Community Paediatrics (2010) and Global Child Health (2014); innovative formative peer assessment; and widening access to other disciplines. Student satisfaction is high and applications remain strong, particularly overseas, despite competing courses across London and at a time when other paediatric MScs are closing around the UK.

The art of teaching is to empower students to achieve their best and I have extended this to several innovative programmes, which develop and support not just academic trainees but others that could eventually contribute to paediatric research. For example, I have:

* Developed the largest paediatric academic programme in the UK with 39 academic fellows and 13 lecturers across nearly every paediatric specialty.

* Helped found the Academic Paediatrics Association and led my trainees (marshaled by John Apps and Chryssie Brown) in developing the Paediatric Academic Trainees Forum. Both thriving nationally and providing representative senior and trainee platforms to campaign for higher paediatric standards.

* Organised academic workshops to interest medical students (with Gwyneth Davies) and clinical track trainees in research, hence belying the belief that academic paediatrics is only for the select few.

* Worked with another academic trainee, Jon Fisher, to pioneer an internet-based search programme using online dating software to match potential researchers with supervisors. Again widening access to all.

Summary:

I am passionate about paediatric education and these activities have established me as a global leader in paediatric teaching and training.

UCL Collaborators

Prof Peter Scambler; Dr Kevin Mills; Prof Simon Heales; Dr Mike Hubank; Prof Therese Hesketh; Dr David Long; Prof Philip Beales; Dr Philippa Mills; Prof Adrian Woolf; Prof Justin Hsuan; Dr Lesley Rees

External Collaborators

Publications

    2015

    • Winyard PJD (2015). Cystic kidney diseases. In RN Srivastava AB (Ed.), Pediatric Nephrology (pp. - ). : Jaypee brothers publishers.
    • Liapis H, Winyard PJD (2015). Cystic diseases and developmental kidney defects. In Jennette JC, Silva FG, Olson JL, D'Agati VD (Ed.), Heptinstall's pathology of the kidney (pp. 119 - 171). : Wolters Kluwer.
    • Winyard PJD (2015). Timetable and mechanisms of human kidney and renal tract development. In Turner N, Winearls C, Remuzzi G, Lameire P, Himmelfarb G (Ed.), Oxford Textbook of Clinical Nephrology (pp. - ). : Oxford University Press.

    2014

    • Winyard PJ, Price KL (2014). Experimental renal progenitor cells: Repairing and recreating kidneys?. Pediatr Nephrol, 29(4), 665 - 672. doi:10.1007/s00467-013-2667-5

    2013

    • Brown CC, Apps JR, Davies G, Ware N, Fisher J, Winyard PJ (2013). Making your way as an academic paediatric trainee in the UK.. Arch Dis Child Educ Pract Ed, , - . doi:10.1136/archdischild-2013-304675
    • Hudson LD, Cumby C, Klaber RE, Nicholls DE, Winyard PJ, Viner RM (2013). Low levels of knowledge on the assessment of underweight in children and adolescents among middle-grade doctors in England and Wales.. Arch Dis Child, 98(4), 309 - 311. doi:10.1136/archdischild-2012-303357
    • Brown CC, Apps JR, Winyard PJ (2013). A new generation of academic paediatricians.. Lancet, 382(9886), 28 - . doi:10.1016/S0140-6736(13)61527-5

    2012

    • Winyard PJD, Price KL (2012). Cystic kidney disease (http://www.pediatricurologybook.com/cystic_kidney_disease.html). In Wilcox DN, Godbole P, Cooper C (Ed.), Free Pediatric Urology Textbook on the Web (pp. - ). : .
    • Brockschmidt A, Chung B, Weber S, Fischer DC, Kolatsi-Joannou M, Christ L, Heimbach A, Shtiza D, Klaus G, Simonetti GD, Konrad M, Winyard P, Haffner D, Schaefer F, Weber RG (2012). CHD1L: a new candidate gene for congenital anomalies of the kidneys and urinary tract (CAKUT).. Nephrol Dial Transplant, 27(6), 2355 - 2364. doi:10.1093/ndt/gfr649
    • Harteneck C, Weber S, Buescher A, Riehle M, Hoyer P, Jeruschke S, Kolatsie M, Nagel M, Winyard P, Gollasch M (2012). Mutations in TRPC6 ion channels in patients suffering from familial focal segmental glomerolusclerosis.

    2011

    • Winyard P, Jenkins D (2011). Putative roles of cilia in polycystic kidney disease.. Biochim Biophys Acta, 1812(10), 1256 - 1262. doi:10.1016/j.bbadis.2011.04.012
    • Kolatsi-Joannou M, Price KL, Winyard PJ, Long DA (2011). Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury.. PLoS One, 6(4), e18683 - . doi:10.1371/journal.pone.0018683
    • Renkema KY, Winyard PJ, Skovorodkin IN, Levtchenko E, Hindryckx A, Jeanpierre C, Weber S, Salomon R, Antignac C, Vainio S, Schedl A, Schaefer F, Knoers NV, Bongers EM, EUCAKUT consortium (2011). Novel perspectives for investigating congenital anomalies of the kidney and urinary tract (CAKUT).. Nephrol Dial Transplant, 26(12), 3843 - 3851. doi:10.1093/ndt/gfr655
    • Winyard PJD, Jenkins D (2011). Putative roles of cilia in polycystic kidney disease.
    • Morgenstern D, Hasan F, Gibson S, Winyard P, Sebire N, Anderson J (2011). PAX5 expression in non haematopoietic tissues; reappraisal of previous studie.. American Journal of Clinical Pathology, , - .

    2010

    • Winyard P (2010). FETAL HYDRONEPHROSIS - SHOULD WE DO A POST NATAL WORK UP OR NOT?. CHILD CARE HEALTH AND DEVELOPMENT, 36, 25 - 25.
    • Winyard PJD (2010). The Kidney. Embryos, Genes and Birth Defects: Second Edition, , 463 - 513. doi:10.1002/9780470090121.ch16
    • Chan SK, Riley PR, Price KL, McElduff F, Winyard PJ, Welham SJ, Woolf AS, Long DA (2010). Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog. American Journal of Physiology - Renal Physiology, 298, F346 - F356. doi:10.1152/ajprenal.00574.2009
    • Morgenstern DA, Hasan F, Gibson S, Winyard P, Sebire NJ, Anderson J (2010). PAX5 Expression in Nonhematopoietic Tissues. AM J CLIN PATHOL, 133(3), 407 - 415. doi:10.1309/AJCPZPQNOLUGKMME

    2009

    • Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Winyard PJ, Cansick J, Bingham C, Edghill EL, Shroff RC, Stanescu H, Ryffel G, Ellard S, Woolf AS (2009). Hepatocyte Nuclear Factor 1B mutations are associated with hypomagnesemia and renal magnesium wasting. PEDIATR NEPHROL, 24(4), 885 - 885.
    • Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Winyard PJ, Cansick J, Bingham C, Edghill EL, Shroff RC, Stanescu H, Ryffel G, Ellard S, Woolf AS (2009). hepatocyte nuclear factor 1 beta mutations are associated with hypomagnesaemia and renal magnesium wasting.
    • Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van 'tHoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Cansick J, Mushtaq I, Dhillon HK, Bingham C, Edghill EL, Shroff R, Stanescu H, Ryffel GU, Ellard S, Bockenhauer D (2009). HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. Journal of the American Society of Nephrology, 20(5), 1123 - 1131.
    • Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Winyard PJ, Cansick J, Bingham C, Edghill EL, Shroff RC, Stanescu H, Ryffel G, Ellard S, Woolf AS (2009). Hepatocyte Nuclear Factor 1B mutations are associated with hypomagnesemia and renal magnesium wasting. Pediatric Nephrology, 24(4), 885 - 885.
    • Hothi DK, Wade AS, Gilbert R, Winyard PJ (2009). Mild Fetal Renal Pelvis Dilatation--Much Ado About Nothing?. Clinical Journal of the American Society of Nephrology, 4(1), 168 - 177.

    2008

    • Winyard P, Chitty LS (2008). Dysplastic kidneys. Semin Fetal Neonatal Med, 13(3), 142 - 151.
    • Wang D, Heywood W, Mills K, Winyard PJD, Chitty LS (2008). Identification of novel protein biomarkers in amnaiotic fluid and fetal urine in fetuses with serious renal abnormalities..
    • Weber S, Taylor JC, Winyard P, Baker KF, Sullivan-Brown J, Schild R, Knuppel T, Zurowska AM, Caldas-Alfonso A, Litwin M, Emre S, Ghiggeri GM, Bakkaloglu A, Mehls O, Antignac C, Network E, Schaefer F, Burdine RD (2008). SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development. J Am Soc Nephrol, 19(5), 891 - 903.
    • Adalat S, Woolf AS, Ledermann SE, Van'T Hoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Dhillon H, Cansick J, Rees L, Bockenhauer D (2008). Hepatocyte nuclear factor 1 beta mutations commonly cause hypomagnesemia. PEDIATR NEPHROL, 23(9), 1654 - 1654.

    2007

    • Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ (2007). Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Physiological Genomics, 28(2), 193 - 202.
    • Liapis H, Winyard P (2007). Cystic diseases and Developmental kidney defects. In Jennette JC, Olson JL, Schwartz MM, Silva FG (Ed.), Heptinstall's pathology of the kidney (pp. 1257 - 1306). : Lippincott Williams and Wilkins.
    • Weber S, Taylor J, Winyard PJD, Baker KF, Schild R, Knuppel T, Zurowska AM, Caldas-Alfonso AC, Litwin M, Emre S, Ghiggeri GM, Bakkaloglu A, Mehls O, Antignac C, ESCAPE Study Group , Schaefer F, Burdine RD (2007). Mutations in SIX2 and BMP4 are associated with anomlous development of the kidney in humans and zebafish. J Am Soc Nephrol, , - .
    • Barratt TM, Ledermann SE, Roy S, Rees L, Goonaskera CG, Dillon MJ, Nash M, van't Hoff W, Feather SA, Winyard PJD, de Bruyn R, Marks SD (2007). Renal Diseases. In Strobel S, Spitz L, Marks S, El Habbal M (Ed.), The Great Ormond Street Colour Handbook of Paediatrics and Child Health (pp. 297 - 311). : Manson Publishing.
    • Jenkins D, Winyard PJ, Woolf AS (2007). Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. Journal of Anatomy, 211(5), 620 - 629.
    • Winyard PJD (2007). Human Renal Development: In vivo insights from In vitro studies.
    • Winyard P, Chitty LS (2007). Dysplastic kidneys. Semin.Fetal Neonatal Med., , - .

    2006

    • Marks SD, Winyard PJD (2006). Pediatric nephrology. In Godbole P, Gearhart JP, Wilcox DT (Ed.), Clinical Problems in Pediatric Urology (pp. 1 - 8). : Blackwell Publishing Limited.
    • Whitten SM, Stojilkovic-Mikic T, Winyard PJ, Chitty LS (2006). OP02. 33: Outcome of prenatally diagnosed echogenic kidneys.
    • Winyard PJ, Cass HD, Stephenson TJ, Wilkinson AR, Olver RE (2006). Developing critical mass and growing our own academics.. Arch Dis Child, 91(12), 1027 - 1029. doi:10.1136/adc.2006.105502
    • Chiu MG, Johnson TM, Woolf AS, hm-Vicker EM, Long DA, Guay-Woodford L, Hillman KA, Bawumia S, Venner K, Hughes RC, Poirier F, Winyard PJ (2006). Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. American Journal of Pathology, 169(6), 1925 - 1938. doi:10.2353/ajpath.2006.060245
    • Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ (2006). Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Physiol Genomics, , - .
    • Winyard PJ, Bharucha T, De BR, Dillon MJ, van't HW, Trompeter RS, Liesner R, Wade A, Rees L (2006). Perinatal renal venous thrombosis: presenting renal length predicts outcome. Archives of Disease in Childhood - Fetal and Neonatal Edition, 91(4), F273 - F278.
    • Dolan V, Alarcon P, Ruddle P, Gerrelli D, Woolf AS, Winyard P, Hensey C (2006). Gremlin, a bone morphogenetic protein antagonist essential for pronephric development, is expressed in normal human renal development and multicystic renal dysplasia. Scottish Medical Journal, 51(1), 55 - 55.
    • Winyard PJ, Cass HD, Stephenson TJ, Wilkinson AR, Olver RE (2006). Developing critical mass and growing our own academics. Archives of Disease Childhood, 91(12), 1027 - 1029.

    2005

    • Jenkins D, Bitner-Glindzicz M, Malcolm S, Hu CCA, Allison J, Winyard PJD, Gullett AM, Thomas DFM, Belk RA, Feather SA, Sun TT, Woolf AS (2005). De novo UPIIIa mutations cause human urinary tract malformations which lead to severe renal failure.
    • Jenkins D, Bitner-Glindzicz M, Malcolm S, Hu CCA, Allison J, Winyard PJD, Gullett AM, Thomas DFM, Belk RA, Feather SA, Sun TT, Woolf AS (2005). De Novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure. Journal of the American Society of Nephrology, 16(7), 2141 - 2149. doi:10.1681/ASN.2004090776

    2004

    • Gonzalez-Martinez D, Kim SH, Hu Y, Guimond S, Schofield J, Winyard P, Vannelli GB, Turnbull J, Bouloux PM (2004). Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism. Journal of Neuroscience, 24(46), 10384 - 10392. doi:10.1523/JNEUROSCI.3400-04.2004
    • Jenkins D, Hu CC, Allison J, Gullett AM, Winyard PJ, Malcolm S, Feather S, Sun TT, Bitner-Glindzicz M, Woolf AS (2004). "De novo mutations in UPIIIA cause severe bilateral renal dysplasia".
    • Romio L, Fry AM, Winyard PJ, Malcolm S, Woolf AS, Feather SA (2004). OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis. Journal of the American Society of Nephrology, 15(10), 2556 - 2568. doi:10.1097/01.ASN.0000140220.46477.5C
    • Romio L, Fry AM, Winyard PJD, Malcolm S, Woolf AS, Feather SA (2004). OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis. doi:10.1097/01.ASN.0000140220.46477.SC
    • Chiu MG, Johnson TM, Woolf AS, Hillman KA, Bawumia S, Hughes RC, Poirier F, Guay-Woodford LM, Winyard PJD (2004). "Galectin-3 retards the development of autosomal recessive polycystic kidney disease and localises to the primary cilium".
    • Woolf AS, Price KL, Scambler PJ, Winyard PJ (2004). Evolving concepts in human renal dysplasia. Journal of the American Society of Nephrology, 15(4), 998 - 1007.
    • Romio L, Fry AM, Winyard PJ, Malcolm S, Woolf AS, Feather SA (2004). OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis.. J Am Soc Nephrol, 15(10), 2556 - 2568. doi:10.1097/01.ASN.0000140220.46477.5C
    • Winyard PJD (2004). Structure and development of the human kidney. In Flinter F, Maher E, Saggar-Malik A (Ed.), The Genetics of Renal Disease (pp. - ). : Oxford University Press.
    • Hillman KA, Woolf AS, Johnson TM, Wade A, Unwin RJ, Winyard PJ (2004). The P2X7 ATP receptor modulates renal cyst development in vitro. Biochemical and Biophysical Research Communications, 322(2), 434 - 439.
    • Chiu MG, Woolf AS, Johnson TM, Hillman KA, Hughes RC, Poirier F, Guay-Woodford L, Winyard PJD (2004). Galectin-3 retards the progression of polycystic kidney disease and localises to the primary cilium.
    • Dolan V, Ruddle P, Gerrelli D, Woolf AS, Hensey C, Winyard PJD (2004). Gremlin, a BMP antagonist, is expressed in human renal development and multicystic renal dysplasia.
    • Parkes HG, Kidane JE, Chitty L, Tse Y, Winyard PJ (2004). NMR studies of amniotic fluid in human fetal urogenital tract obstruction.
    • Hillman KA, Woolf AS, Johnson TM, Wade A, Unwin RJ, Winyard PJD (2004). The P2X(7) ATP receptor modulates renal cyst development in vitro. Biochem.Biophys.Res.Commun., 322(2), 434 - 439.
    • Gonzalez-Martinez D, Winyard P, Woolf AS, Bouloux PM (2004). GnRH, anosmin-1 and FGFR1 immunoreactivity in the developing human brain.

    2003

    • Mulroy S, Boucher C, Winyard PJD, Sandford R (2003). Cystic Renal Disease. In Vize PD, Woolf AS, Bard JBL (Ed.), The Kidney (pp. - ). : Academic Press.
    • Winyard PJD, Woolf AS, Price K (2003). LIF signaling in human renal development..
    • Romio L, Wright V, Price K, Winyard PJ, Donnai D, Porteous ME, Franco B, Giorgio G, Malcolm S, Woolf AS, Feather SA (2003). OFD1, the gene mutated in Oral-Facial-Digital syndrome type 1, Is expressed in the metanephros and in human embryonic renal mesenchymal cells. J Am Soc Nephrol, 14(3), 680 - 689.
    • Hillman KA, Unwin RJ, Woolf AS, Winyard PJD (2003). P2X7 signaling Is a modifier of epithelial lumen formation.
    • Hillman KA, Unwin RJ, Woolf AS, Winyard PJ (2003). P2X7 signalling is a modifier of epithelial lumen formation..
    • Romio L, Wright V, Price K, Winyard PJ, Donnai D, Porteous ME, Franco B, Giorgio G, Malcolm S, Woolf AS, Feather SA (2003). OFD1, the gene mutated in oral-facial-digital syndrome type 1, is expressed in the metanephros and in human embryonic renal mesenchymal cells. Journal of the American Society of Nephrology, 14(3), 680 - 689.
    • Woolf AS, Welham SJM, Hermann MM, Winyard PJD (2003). Maldevelopment of the human kidney and lower urinary tract: an overview.. In Vize PD, Woolf AS, Bard JBL (Ed.), The Kidney: from Normal Development to Congenital Disease (pp. 377 - 393). : Amsterdam, Elsevier Science/Academic Press.
    • Winyard PJ, Woolf AS, Price KL (2003). LIF signalling in human renal development..

    2002

    • Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJ, Peebles DM, Woolf AS, Cuckow PM (2002). Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation. The Journal of Urology, 168(4), 1615 - 1620.
    • Romio L, Wright V, Price K, Winyard PJD, Malcolm S, Woolf AS, Feather SA (2002). The Oral-facial-digital syndrome type 1 gene codes for human metanphric mesenchimal protein..
    • Hillman KA, Johnson TM, Unwin RJ, Woolf AS, Winyard PJ (2002). The P2X7 ATP receptor modulates renal cyst morphogenesis.. J AM SOC NEPHROL, 13, 115A - 115A.
    • Woolf AS, Winyard PJ (2002). Molecular mechanisms of human embryogenesis: developmental pathogenesis of renal tract malformations. Pediatr Dev Pathol, 5(2), 108 - 129.
    • Johnson TM, Hughes RC, Poirier F, Woolf AS, Winyard PJD (2002). Galectin-3 is overexpressed in collecting duct cysts in cpk/cpk mice and downregulated by Taxol in vivo and in vitro. American Society of Nephrology.
    • Romio L, Wright V, Reynolds K, Winyard PJD, Malcolm S, Woolf AS, Feather SA (2002). The protein mutated in the oral-facial-digital syndrome type 1 is a metanephric mesenchymal factor.. J AM SOC NEPHROL, 13, 18A - 18A.
    • Hillman KA, Johnson TM, Winyard PJ, Burnstock G, Unwin RJ, Woolf AS (2002). P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Experimental Nephrology, 10(1), 34 - 42.
    • Hillman KA, Johnson TM, Unwin RJ, Woolf AS, Winyard PJD (2002). The P2X7 ATP receptor modulates renal cyst morphogenesis.
    • Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJD, Peebles DM, Woolf AS, Cuckow PM (2002). Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation. Journal of Urology, 168(4 I), 1615 - 1620.
    • Hillman KA, Johnson TM, Winyard PJ, Burnstock G, Unwin RJ, Woolf AS (2002). P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Exp.Nephrol., 10(1), 34 - 42.
    • Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJD, Peebles DM, Woolf AS, Cuckow PM (2002). Fetal sheep bladder outflow obstruction perturbs detrusor contractility, volume-pressure relationships and innervation. The Journal of Urology, 168, 1615 - 1620.
    • Price K, Woolf AS, Winyard PJD (2002). Human dysplastic kidney mesenchyme cells generate a perturbed milieu of HGF and GDNF, classical ureteric bud morphogens.

    2001

    • Yang SP, Woolf AS, Quinn F, Winyard PJD (2001). Deregulation of renal transforming growth factor-β1 after experimental short-term ureteric obstruction in fetal sheep. American Journal of Pathology, 159(1), 109 - 117.
    • Winyard P, Chitty L (2001). Dysplastic and polycystic kidneys: diagnosis, associations and management. Prenat Diagn, 21(11), 924 - 935.
    • Cuckow PM, Nyirady P, Winyard PJD (2001). Normal and abnormal development of the urogenital tract. Prenatal Diagnosis, 21(11), 908 - 916.
    • Yang SP, Woolf AS, Quinn F, Winyard PJD (2001). Deregulation of renal transforming growth factor-1 after experimental short-term ureteric obstruction in fetal sheep.
    • Nyirady P, Thiruchevlan N, Fry CH, Peebles DH, Godley ML, Winyard PJD, Woolf AS, Rodeck CH, Cuckow PH (2001). PUV in an animal model - electromechanical properties of detrusor smooth muscle. doi:10.1046/j.1464-410X.2001.0880s1001.x
    • Winyard P, Chitty L (2001). Mild pyelectasis. Prenatal Diagnosis, 21(11), 936 - 941. doi:10.1002/pd.204
    • Nyirady P, Cuckow PM, Winyard PJD (2001). Animal models of fetal renal disease. Prenatal Diagnosis, 21(11), 917 - 923. doi:10.1002/pd.211
    • Johnson TM, Woolf AS, Poirier F, Hughes RC, Winyard PJD (2001). Galectin-3 is upregulated in cpk/cpk mouse polycystic kidney disease and decreased epithelial expression correlates with reduced cyst growth in vivo and in vitro following paclitaxel therapy. J Am Soc Nephrol, 12, 537A - .
    • Deeb A, Robertson A, McColl G, Bouloux PMG, Winyard PJD, Woolf AS, Moghal NE, Cheetham TD (2001). X linked Kallmann Syndrome and multicystic dysplastic kidney - a new association.. Nephrol Dial Transplant, 16(6), 1170 - 1175.
    • Yang SP, Woolf AS, Quinn F, Winyard PJD (2001). Deregulation of renal transforming growth factor beta 1 after experimental short-term ureteric obstruction in fetal sheep. American Journal of Pathology, 159(1), 109 - 117.
    • Deeb A, Robertson A, MacColl G, Bouloux PM, Gibson M, Winyard PJ, Woolf AS, Moghal NE, Cheetham TD (2001). Multicystic dysplastic kidney and Kallmann\'s syndrome: a new association?. Nephrology Dialysis Transplantation, 16(6), 1170 - 1175.
    • Bullock SL, Johnson TM, Bao Q, Hughes RC, Winyard PJ, Woolf AS (2001). Galectin-3 modulates ureteric bud branching in organ culture of the developing mouse kidney. Journal of the American Society of Nephrology, 12(3), 515 - 523.

    2000

    • Nishizawa S, Peters J, Cuckow PM, Winyard PJD (2000). Congenital kidney and bladder malformations in the T(2;11)30H mouse. UK Renal Association, London, April 2000, , - .
    • Winyard PJD, Sidwell R (2000). Renal. In Sidwell R, Thompson M (Ed.), Concise Paediatrics (pp. 211 - 246). : Greenwich Medical Media.
    • Cale CM, Klein NJ, Winyard PJ, Woolf AS (2000). Inflammatory mediators in human renal dysplasia. Nephrology Dialysis Transplantation, 15(2), 173 - 183.
    • Yang SP, Woolf AS, Yuan HT, Winyard PJD, Anthony Risdon R, Scott RJ, O'Hare MJ (2000). Potential biological role of transforming growth factor-β1 in human congenital kidney malformations. American Journal of Pathology, 157(5), 1633 - 1647.
    • Yang SP, Woolf AS, Yuan HT, Scott RJ, Risdon RA, O'Hare MJ, Winyard PJD (2000). Biological role of transforming growth factor 1 in human congenital kidney malformations.
    • Nishizawa S, Peters J, Cuckow PM, Winyard PJD (2000). Congenital kidney and bladder malformations in the T(2;11)30H mouse.
    • Woolf AS, Winyard PJ (2000). Gene expression and cell turnover in human renal dysplasia. Histol Histopathol., 15(1), 159 - 166.
    • Yang SP, Woolf AS, Yuan HT, Scott RJ, Risdon RA, O'Hare MJ, Winyard PJ (2000). Potential biological role of transforming growth factor beta 1 in human congenital kidney malformations. American Journal of Pathology, 157(5), 1633 - 1647.

    1999

    • Winyard PJD, Liesner R, Trompeter RS, Rees LR (1999). Neonatal renal venous thrombosis - predisposing factors, management and outcome.
    • Attar R, Winyard PJD, Quinn F, Mouriquand PDE, Duffy P, Hanson MA, Foxall P, Woolf AS (1999). Biology of fetal glomerulocystic disease associated with ureteric obstruction..
    • Winyard PJD, Yang SP, Maric C, Scott R, Risdon R, O'Hare MJ, Woolf AS (1999). Aberrant expression of components of the renin-angiotensin system in human renal dysplasia.
    • Ascham H, Koleros D, Winyard PJD, Quinn F, Hanson MA, Woolf A.S. (1999). Brief fetal urinary flow impairment causes metanephric transdifferentiation to smooth muscle lineage. Journal of the American Society of Nephrology, 10, 402 - .
    • Shah NF, Smith VV, Malone M, Lindley KJ, Winyard P, Milla PJ (1999). Hypertrophic Eosinophilic Gastrenteropathy: Apoptotic failure in a new syndrome.

    1998

    • Winyard PJD (1998). The Biology of Kidney Malformations, PhD Thesis.
    • Winyard P, Chaudhry B, Cale C (1998). A new college, a new direction in academic paediatrics?. Arch Dis Child, 78(4), 399 - .
    • Woolf AS, Winyard PJ (1998). Advances in the cell biology and genetics of human kidney malformations. J Am Soc Nephrol, 9(6), 1114 - 1125.
    • Attar R, Quinn F, Winyard PJD, Mouriquand PDE, Foxall P, Hanson MA, Woolf AS (1998). Short-term urinary flow impairment deregulates PAX2 and PCNA expression and cell survival in fetal sheep kidneys. AM J PATHOL, 152(5), 1225 - 1235.
    • Winyard PJD, Chaudhry B, Cale CM (1998). A new college, a new direction in academic paediatrics? [letter; comment]. Arch.Dis.Child, 78(4), 399 - .
    • Attar R, Quinn F, Winyard PJD, Mouriquand PDE, Foxall P, Hanson MA, Woolf A (1998). Short term urinary flow impairment deregulates PAX 2 expression, proliferation and cell survival in fetal sheep kidneys. American Journal of Pathology, 152(5), 1225 - 1235.

    1997

    • Chaudhry B, Winyard P, Cale C (1997). Academia: the view from below [editorial] [see comments]. BMJ, 315(7108), 560 - 561.
    • Winyard PJD, Bao Q, Hughes RC, Woolf AS (1997). Apical galectin-3 in normal nephrogenesis and dysplastic renal epithelia.
    • Kolatsi-Joannou M, Moore R, Winyard PJ, Woolf AS (1997). Expression of hepatocyte growth factor/scatter factor and its receptor, MET, suggests roles in human embryonic organogenesis. Pediatric Research, 41(5), 657 - 665.
    • Feather SA, Winyard PJ, Dodd S, Woolf AS (1997). Oral-facial-digital syndrome type 1 is another dominant polycystic kidney disease: clinical, radiological and histopathological features of a new kindred. Nephrology Dialysis Transplantation, 12(7), 1354 - 1361.
    • Chaudhry B, Winyard P, Cale C (1997). Academia: the view from below. BMJ (Clinical Research Ed.), 315(7108), 560 - 561.
    • Feather SA, Winyard PJD, Dodd S, Woolf AS (1997). Oral-facial-digital syndrome type I is another dominant polycystic kidney disease.. KIDNEY INT, 52(4), 1131 - 1131.
    • Winyard PJ, Bao Q, Hughes RC, Woolf AS (1997). Epithelial galectin-3 during human nephrogenesis and childhood cystic diseases. Journal of the American Society of Nephrology, 8(11), 1647 - 1657.
    • Chaudhry B, Winyard P, Cale C (1997). Academia: The view from below. A national career structure is needed for medical academics. British Medical Journal, 315(7108), 560 - 561.

    1996

    • Winyard PJ, Nauta J, Lirenman DS, Hardman P, Sams VR, Risdon RA, Woolf AS (1996). Deregulation of cell survival in cystic and dysplastic renal development. Kidney International, 49(1), 135 - 146.
    • Winyard PJD, Feather SA (1996). Genetics of human kidney malformations.
    • Winyard PJ, Risdon RA, Sams VR, Dressler GR, Woolf AS (1996). The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J Clin Invest, 98(2), 451 - 459.
    • Woolf AS, Bao Q, Hughes RC, Winyard PJD (1996). Galectin-3 in normal, polycystic and dysplastic nephrogenesis.
    • Murch SH, Winyard PJ, Koletzko S, Wehner B, Cheema HA, Risdon RA, Phillips AD, Meadows N, Klein NJ, Walker-Smith JA (1996). Congenital enterocyte heparan sulphate deficiency with massive albumin loss, secretory diarrhoea, and malnutrition. The Lancet, 347(9011), 1299 - 1301.

    1995

    • Duke VM, Winyard PJ, Thorogood P, Soothill P, Bouloux PM, Woolf AS (1995). KAL, a gene mutated in Kallmann's syndrome, is expressed in the first trimester of human development. Molecular and Cellular Endocrinology, 110(1-2), 73 - 79.
    • Woolf AS, Winyard PJ (1995). Unravelling the pathogenesis of cystic kidney diseases. Arch Dis Child, 72(2), 103 - 105.
    • Winyard PJD, Risdon RA, Woolf AS (1995). WT1 expression in the absence of bcl-2 may explain excessive apoptosis which occurs in human kidney malformations.

    1994

    • Winyard PJD, Duke VM, Soothill P, Thorogood P, Bouloux PM, Woolf AS (1994). KAL gene expression during embryonic development explains the renal malformations in Kallmann's Syndrome.
    • Hardman P, Kolatsi M, Winyard PJ, Towers PR, Woolf AS (1994). Branching out with the ureteric bud. Exp Nephrol, 2(4), 211 - 219.
    • WINYARD PJD, LIRENMAN DS, RISDON RA, SAMS VR, WOOLF AS (1994). WIDESPREAD APOPTOSIS OCCURS IN HUMAN RENAL MALFORMATIONS AND CHILDHOOD POLYCYSTIC KIDNEY-DISEASE (P K D). J AM SOC NEPHROL, 5(3), 641 - 641.
    • WINYARD PJD, DUKE VM, THOROGOOD PV, NORMAN JT, BOULOUX PMG, WOOLF AS (1994). RENAL APLASIA (RA) IN KALLMANNS-SYNDROME (KS) MAY BE EXPLAINED BY KAL GENE-EXPRESSION DURING NEPHROGENESIS. J AM SOC NEPHROL, 5(3), 640 - 640.
    • Thornton PS, Alter CA, Katz LE, Gruccio DA, Winyard PJ, Moshang T, Jr (1994). The new highly sensitive adrenocorticotropin assay improves detection of patients with partial adrenocorticotropin deficiency in a short-term metyrapone test. Journal of Pediatric Endocrinology and Metabolism, 7(4), 317 - 324.

    1992

    • Winyard P, Thornton P, Grucio D, Moshang T (1992). Growth following treatment for head and neck sarcoma in children.

    • Polubothu S, Mari C, Price KL, Winyard PJD (). Renal dysplasia; good cells gone bad?.
    • Price KL, Mari C, Polubothu S, AlHarbi A, Winyard PJD (). Novel generation and characterisation of human renal progenitor/stem cell lines.
    • Mari C, Price KL, Polubothu S, Alharbi A, Winyard PJD (). Novel generation and characterisation of human renal progenitor/stem cell lines.
    • Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJM, McDonald DM, Price KL, Winyard PJD, Long DA (). Vascular endothelial growth factor C therapy for polycystic kidney diseases.
    • Winyard PJD, Huang JL, Peters DJM, Sandford RN, Long DA (). Critical functional importance of the blood and lymphatic vasculature in polycystic kidney diseases.
    • Richardson ARW, Polubothu S, Sinha MD, Kerecuk L, Winyard PJD (). Autosomal dominant polycystic kidney disease in childhood, what are we doing?.