Dr Nikhil Thapar

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Personal Profile

Name: Nikhil Thapar Email: n.thapar@ucl.ac.uk
Title: Dr Tel:
Department: ICH Development Bio & Cancer Prog Fax:
Position: Clinician Scientist Address: , , ,
Research Domain: Basic Life Sciences, Personalised Medicine, Populations & Lifelong Health, Reproduction & Development Web Page: Personal Web Page

Profile

Research Description

Dr Thapar leads a research programme studying the pathogenesis and treatment of gut motility disorders with a particular focus on improving diagnosis, understanding the molecular and genetic mechanisms underlying such disorders as well as the developing novel therapies including stem cells and gut tissue engineering. The team have been responsible for improved diagnostics and have made significant progress in the understanding of normal and aberrant development of the enteric neuro-musculature and development of stem cell therapies for gut disease.

Research Activities

Better understand normal and abnormal development of the neuromuscular components of the gastrointestinal tract.

Development of novel stem cell-based therapies for aganglionic gut disorders

Development of the enteric neuromusculature

Enteric Nervous System Stem Cells

Normal and abnormal development of the neuromuscular components of the gut

Novel therapies for gut disorders/diseases

Education Description

Dr Thapar is keenly involved in undergraduate and postgraduate education. He is for teaching medical students and leads SSC sessions in paediatric gastroenterology. He is a lecturer for the professional paediatric postgraduate exams (MRCPCH) and involved in courses for both MRCPCH part 1 and 2. Dr Thapar is a founder and co-executive director of the Academy of Paediatric Gastroenterology (www.a-p-g.org), one of the largest initiatives for the education of the multidisciplinary clinical team involved in the care of paediatric gastroenterology patients. The academy runs approximately 10 courses every year from parent education days through to specialist courses for paediatric gastroenterologists and includes both face-to-face teaching courses as well as online learning. He is co-lead and module director for paediatric gastroenterology for UCL's MSc in Paediatrics run from UCL Institute of Child Health. He is on the teaching faculty of the European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) and has been involved in international schools in Europe and Africa.

UCL Collaborators

Dr Suwan Jayasinghe; Dr Richard Day; Dr Vassilis Pachnis; Dr Simon Eaton; Prof Philip Beales; Prof Paolo De Coppi; Dr Alan Burns

External Collaborators

Professor Robert Hofstra; Dr Allan Goldstein; Professor Wood Yee Chan

Publications

    2015

    • Mutalib M, Sintusek P, Punpanich D, Thapar N, Lindley K (2015). A new method to estimate catheter length for esophageal multichannel intraluminal impedance monitoring in children.. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, , - . doi:10.1111/nmo.12547
    • Heuschkel RB, Gottrand F, Devarajan K, Poole H, Callan J, Dias JA, Karkelis S, Papadopoulou A, Husby S, Ruemmele F, Schäppi MG, Wilschanski M, Lionetti P, Orel R, Tovar J, Thapar N, Vandenplas Y (2015). ESPGHAN position paper on management of percutaneous endoscopic gastrostomy in children and adolescents.. J Pediatr Gastroenterol Nutr, 60(1), 131 - 141. doi:10.1097/MPG.0000000000000501
    • Heuschkel RB, Devarajan K, Poole H, Callan J, Gottrand F, Dias JA, Karkelis S, Papadopoulou A, Husby S, Ruemmele F, Schäppi MG, Wilschanski M, Lionetti P, Orel R, Tovar J, Thapar N, Vandenplas Y (2015). ESPGHAN position paper on management of percutaneous endoscopic gastrostomy in children and adolescents. Journal of Pediatric Gastroenterology and Nutrition, 60(1), 131 - 141. doi:10.1097/MPG.0000000000000501
    • Tambucci R, Thapar N, Saliakellis E, Pescarin M, Quitadamo P, Cristofori F, Lindley KJ, Borrelli O (2015). Clinical Relevance of Esophageal Baseline Impedance Measurement: Just an Innocent Bystander.. J Pediatr Gastroenterol Nutr, , - . doi:10.1097/MPG.0000000000000709
    • Binder E, Natarajan D, Cooper J, Kronfli R, Cananzi M, Delalande J-M, McCann C, Burns AJ, Thapar N (2015). Enteric neurospheres are not specific to neural crest cultures: Implications for neural stem cell therapies. PLoS ONE, 10(3), - . doi:10.1371/journal.pone.0119467

    2014

    • Delalande JM, Vernay B, Natarajan D, Finlay M, Ruhrberg C, Thapar N, Burns AJ (2014). Vascularisation is not necessary for gut colonisation by enteric neural crest cells. Developmental Biology, 385(2), 220 - 229. doi:10.1016/j.ydbio.2013.11.007
    • Natarajan D, Cooper J, Choudhury S, Delalande JM, Howe SJ, Thapar N, Burns AJ (2014). Lentiviral labeling of mouse and human enteric nervous system stem cells for regenerative medicine studies. Neurogastroenterology and Motility, 26(10), 1513 - 1518. doi:10.1111/nmo.12420
    • Delalande J-M, Natarajan D, Vernay B, Thapar N, Burns AJ, Finlay M, Ruhrberg C (2014). Vascularisation is not necessary for gut colonisation by enteric neural crest cells. Developmental Biology, 385(2), 220 - 229. doi:10.1016/j.ydbio.2013.11.007
    • Koletzko B, Benninga MA, Godfrey KM, Hornnes PJ, Kolaček S, Koletzko S, Lentze MJ, Mader S, McAuliffe FM, Oepkes D, Oddy WH, Phillips A, Rzehak P, Socha P, Szajewska H, Symonds ME, Taminiau J, Thapar N, Troncone R, Vandenplas Y, Veereman G (2014). Public-private collaboration in clinical research during pregnancy, lactation, and childhood: joint position statement of the Early Nutrition Academy and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.. J Pediatr Gastroenterol Nutr, 58(4), 525 - 530. doi:10.1097/MPG.0000000000000284
    • Borrelli O, Mancini V, Thapar N, Ribolsi M, Emerenziani S, de'Angelis G, Bizzarri B, Lindley KJ, Cicala M (2014). Dilated intercellular space diameter as marker of reflux-related mucosal injury in children with chronic cough and gastro-oesophageal reflux disease.. Aliment Pharmacol Ther, 39(7), 733 - 742. doi:10.1111/apt.12652
    • Cristofori F, Thapar N, Saliakellis E, Kumaraguru N, Elawad M, Kiparissi F, Köglmeier J, Andrews P, Lindley KJ, Borrelli O (2014). Efficacy of the neurokinin-1 receptor antagonist aprepitant in children with cyclical vomiting syndrome.. Aliment Pharmacol Ther, 40(3), 309 - 317. doi:10.1111/apt.12822
    • Domínguez-Ortega G, Borrelli O, Meyer R, Dziubak R, De Koker C, Godwin H, Fleming C, Thapar N, Elawad M, Kiparissi F, Fox AT, Shah N (2014). Extraintestinal manifestations in children with gastrointestinal food allergy.. J Pediatr Gastroenterol Nutr, 59(2), 210 - 214. doi:10.1097/MPG.0000000000000391

    2013

    • Shamir R, St James-Roberts I, Lorenzo CD, Burns AJ, Thapar N, Indrio F, Riezzo G, Raimondi F, Mauro AD, Francavilla R, Leuchter RH-V, Darque A, Hüppi PS, Heine RG, Bellaïche M, Levy M, Jung C, Alvarez M, Hovish K (2013). Infant crying, colic, and gastrointestinal discomfort in early childhood: A review of the evidence and most plausible mechanisms. Journal of Pediatric Gastroenterology and Nutrition, 57(SUPPL.1), - . doi:10.1097/01.mpg.0000441923.90436.c7
    • Meyer R, Fleming C, Dominguez-Ortega G, Lindley K, Michaelis L, Thapar N, Elawad M, Chakravarti V, Fox AT, Shah N (2013). Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit.. World Allergy Organ J, 6(1), 13 - . doi:10.1186/1939-4551-6-13
    • Saliakellis E, Borrelli O, Thapar N (2013). Paediatric GI emergencies.. Best Pract Res Clin Gastroenterol, 27(5), 799 - 817. doi:10.1016/j.bpg.2013.08.013
    • Hotta R, Natarajan D, Thapar N (2013). Advances in enteric neural stem cell biology: How close are we to use them in defecation disorders?. Constipation in Children: Diagnosis and Treatment, , 357 - 370.
    • Shamir R, St James-Roberts I, Di Lorenzo C, Burns AJ, Thapar N, Indrio F, Riezzo G, Raimondi F, Di Mauro A, Francavilla R, Leuchter RH, Darque A, Hüppi PS, Heine RG, Bellaïche M, Levy M, Jung C, Alvarez M, Hovish K (2013). Infant crying, colic, and gastrointestinal discomfort in early childhood: a review of the evidence and most plausible mechanisms.. J Pediatr Gastroenterol Nutr, 57 Suppl 1, S1 - 45. doi:10.1097/MPG.0b013e3182a154ff
    • Burns AJ, Thapar N (2013). Developmental and postnatal changes in the enteric nervous system. Journal of Pediatric Gastroenterology and Nutrition, , - . doi:10.1097/01.mpg.0000441925.75189.01
    • Giorgio V, Borrelli O, Smith VV, Rampling D, Köglmeier J, Shah N, Thapar N, Curry J, Lindley KJ (2013). High-resolution colonic manometry accurately predicts colonic neuromuscular pathological phenotype in pediatric slow transit constipation.. Neurogastroenterol Motil, 25(1), 70-8.e8-9 - . doi:10.1111/nmo.12016

    2012

    • Thapar N, Burns A (2012). Use of enteric nervous stem cells to treat motility disorders: Ready for prime time?. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 15 - 15.
    • Borrelli O, Mancini V, Thapar N, Giorgio V, Elawad M, Hill S, Shah N, Lindley KJ (2012). Cow's milk challenge increases weakly acidic reflux in children with cow's milk allergy and gastroesophageal reflux disease.. J Pediatr, 161(3), 476 - 481.e1. doi:10.1016/j.jpeds.2012.03.002
    • Totonelli G, Maghsoudlou P, Garriboli M, Georgiades F, Delalande JM, Thapar N, Pierro A, Eaton S, Burns AJ, De Coppi P (2012). Recellularization of a natural intestinal matrix using chicken chorioallantoic membrane as an in vivo bioreactor.
    • Panza E, Knowles CH, Graziano C, Thapar N, Burns AJ, Seri M, Stanghellini V, De Giorgio R (2012). Genetics of human enteric neuropathies.. Prog Neurobiol, 96(2), 176 - 189. doi:10.1016/j.pneurobio.2012.01.001
    • Volonaki E, Sebire NJ, Borrelli O, Lindley KJ, Elawad M, Thapar N, Shah N (2012). Gastrointestinal endoscopy and mucosal biopsy in the first year of life: indications and outcome.. J Pediatr Gastroenterol Nutr, 55(1), 62 - 65. doi:10.1097/MPG.0b013e3182478f83
    • Freem LJ, Delalande JM, Campbell AM, Thapar N, Burns AJ (2012). Lack of organ specific commitment of vagal neural crest cell derivatives as shown by back-transplantation of GFP chicken tissues. The International Journal of Developmental Biology, 56, 245 - 254. doi:10.1387/ijdb.113438lf
    • Thapar N (2012). Genetics of human enteric neurophaties. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 13 - 13.

    2011

    • Hotta R, Natarajan D, Burns AJ, Thapar N (2011). Stem cells for GI motility disorders.. Curr Opin Pharmacol, 11(6), 617 - 623. doi:10.1016/j.coph.2011.09.004
    • Sribudiani Y, Metzger M, Osinga J, Rey A, Burns AJ, Thapar N, Hofstra RM (2011). Variants in RET associated with Hirschsprung disease affect binding of transcription factors and gene expression. Gastroenterology, 140(2), 572 - 582. doi:10.1053/j.gastro.2010.10.044
    • Hotta R, Thapar N (2011). Advances in enteric neurobiology: how close are we to clinical use?. J Pediatr Gastroenterol Nutr, 53 Suppl 2, S43 - S45.
    • Thapar N (2011). Clinical picture of intestinal pseudo-obstruction syndrome.. J Pediatr Gastroenterol Nutr, 53 Suppl 2, S58 - S59.
    • Freem LJ, Tannahill D, Thapar N, Burns AJ (2011). Colonisation of the developing mouse lung by neural crest cells as demonstrated by Optical Projection Tomography. J ANAT, 218(3), 359 - 359.

    2010

    • Freem LJ, Escot S, Tannahill D, Druckenbrod NR, Thapar N, Burns AJ (2010). The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice.. J Anat, 217(6), 651 - 664. doi:10.1111/j.1469-7580.2010.01295.x
    • Keshaw H, Thapar N, Burns AJ, Knowles J, Forbes A, Day RM (2010). Microporous collagen spheres produced via thermally induced phase separation for tissue regeneration. Acta Biomaterialia, 6(3), 1158 - 1166. doi:10.1016/j.actbio.2009.08.044
    • Goldani HA, Staiano A, Borrelli O, Thapar N, Lindley KJ (2010). Pediatric esophageal high-resolution manometry: utility of a standardized protocol and size-adjusted pressure topography parameters.. Am J Gastroenterol, 105(2), 460 - 467. doi:10.1038/ajg.2009.656
    • Shah N, Thompson A, Strautnieks S, Milla P, Hill S, Lindley K, Thapar N, Scambler P, Thompson R (2010). PREDICTING THE OUTCOME OF CONGENITAL INTESTINAL FAILURE. J PEDIATR GASTR NUTR, 50, E171 - E172.
    • Binder E, Cananzi M, Burns AJ, Thapar N (2010). ENTERIC NERVOUS SYSTEM STEM CELL-CONTAINING NEUROSPHERES: ALL THAT GLITTERS IS NOT GOLD?. doi:10.1136/gut.2009.209049g
    • Freem LJ, Escot S, Tannahill D, Druckenbrod NR, Thapar N, Burns AJ (2010). The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice.. Journal of Anatomy, Epub ahead of print, - . doi:10.1111/j.1469-7580.2010.01295.x.

    2009

    • Thapar N (2009). ENS stem cells: practical problems, practical solutions. NEUROGASTROENT MOTIL, 21(2), XXIX - XXIX.
    • Burns AJ, Bradshaw L, Davey MG, Thapar N (2009). Defects in gut and enteric nervous system development in Talpid3 mutant chicken. doi:10.1016/j.mod.2009.06.566
    • Alexander N, Eaton S, Haston M, Wallace AS, Smith VV, Burns AJ, Salomon J, Shah N, Klein NJ, Pierro A, Thapar N (2009). Hirschsprung's disease associated enterocolitis is related to defects in innate immunity.
    • Metzger M, Caldwell C, Barlow AJ, Burns AJ, Thapar N (2009). Therapeutic potential of human enteric nervous system stem cells derived from endoscopic gut mucosal biopsies.
    • Burns AJ, Wallace AS, Barlow AJ, Navaratne L, Delalande J-M, Thapar N, Tauszig-Delamasure S, Corset V (2009). Inhibition of cell death results in hyperganglionosis: Implications for enteric nervous system development. Neurogastroenterology and Motility, 21(7), - . doi:10.1111/j.1365-2982.2009.01309.x
    • Metzger M, Caldwell C, Barlow AJ, Burns AJ, Thapar N (2009). Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders.. Gastroenterology, 136(7), 2214-25.e1-3 - . doi:10.1053/j.gastro.2009.02.048
    • Freem LJ, Thapar N, Burns AJ (2009). Investigation of the embryological origin and development of intrinsic nerve ganglia within the mouse and human lung. Journal of Anatomy, 215(6), 710 - 711.
    • Metzger M, Wallace AS, Schaefer KH, Burns AJ, Thapar N (2009). Development of the mucosal plexus of the human enteric nervous system.
    • Wallace AS, Barlow AJ, Navaratne L, Delalande JM, Tauszig-Delamasure S, Corset V, Thapar N, Burns AJ (2009). Inhibition of cell death results in hyperganglionosis: implications for enteric nervous system development. Neurogastroenterology and Motility, 21(7), 768 - e49. doi:10.1111/j.1365-2982.2009.01309.x
    • Hotta R, Natarajan D, Thapar N (2009). Potential of cell therapy to treat pediatric motility disorders. Seminars in Pediatric Surgery, 18(4), 263 - 273.
    • Freem LJ, Escot S, Thapar N, Burns AJ (2009). Colonisation of the developing lungs by tangential migration of foregut-derived vagal neural crest cells.
    • Thapar N (2009). New frontiers in the treatment of Hirschsprung disease. J Pediatr Gastroenterol Nutr, 48 Suppl 2, S92 - S94.
    • Freem L, J T, N B, A J (2009). Development of intrinsic lung neurons from foregut-derived neural crest cells. doi:10.1016/j.mod.2009.06.878
    • Burns AJ, Bradshaw L, Freem LJ, Davey MG, Thapar N (2009). Analysis of talpid3 mutant chicken embryos reveals defects in gut and enteric nervous system development.
    • Metzger M, Caldwell C, Barlow AJ, Burns AJ, Thapar N (2009). Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders. Gastroenterology, 136(7), 2214 - 2225.

    2008

    • Burns AJ, Thapar N, Barlow AJ (2008). Development of the Neural Crest-derived Intrinsic Innervation of the Human Lung. American Journal of Respiratory Cell and Molecular Biology, 38(3), 269 - 275. doi:10.1165/rcmb.2007-0246OC
    • Thapar N, Lindley KJ, Kiparissi F, Elawad MA, Ashworth M, Veys P, Gaspar HB, Hill SM, Milla PJ, Shah N (2008). Treatment of intractable ulcerating enterocolitis of infancy by allogeneic bone marrow transplantation.. Clin Gastroenterol Hepatol, 6(2), 248 - 250. doi:10.1016/j.cgh.2007.11.019
    • Delalande J-M, Barlow AJ, Wallace AS, Thapar N, Burns AJ, Thomas AJ, Erickson CA (2008). The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells. Developmental Biology, 313(1), 279 - 292. doi:10.1016/j.ydbio.2007.10.028
    • Barlow AJ, Wallace AS, Thapar N, Burns AJ (2008). Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation. Development, 135(9), 1681 - 1691. doi:10.1242/dev.017418
    • Delalande JM, Barlow AJ, Thomas AJ, Wallace AS, Thapar N, Erickson CA, Burns AJ (2008). The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells.. Developmental Biology, 313(1), 279 - 292. doi:10.1016/j.ydbio.2007.10.028
    • Barlow AJ, Wallace AS, Thapar N, Burns AJ (2008). Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation. Development, 135(9), 1681 - 1691. doi:10.1242/dev.017418

    2007

    • Thapar N (2007). Future horizons in the treatment of enteric neuropathies.. J Pediatr Gastroenterol Nutr, 45 Suppl 2, S110 - S114. doi:10.1097/MPG.0b013e31812e667c
    • Burns AJ, Thapar N, Barlow AJ (2007). Development of the Neural Crest-derived Intrinsic Innervation of the Human Lung.

    2006

    • Bondurand N, Natarajan D, Barlow A, Thapar N, Pachnis V (2006). Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling.. Development, 133(10), 2075 - 2086.
    • Burns AJ, Thapar N (2006). Advances in ontogeny of the enteric nervous system. Neurogastroenterol Motil, 18(10), 876 - 887. doi:10.1111/j.1365-2982.2006.00806.x
    • Thapar N, Natarajan D, Caldwell C, Burns AJ, Pachnis V (2006). Isolation of enteric nervous system progenitors from Hirschsprung’s-like gut.

    2005

    • Thapar N, Shah N, Ramsay TD, Lindley KJ, Milla PJ (2005). Long-term outcome of intractable ulcerating enterocolitis of infancy. Journal of Pediatric Gastroenterology and Nutrition, 40(5), 582 - 588.

    2004

    • Thapar N, Sanderson IR (2004). Diarrhoea in children: an interface between developing and developed countries. The Lancet, 363(9409), 641 - 653.

    • Burns AJ, Thapar N (). Neural stem cell therapies for enteric nervous system disorders. Nature Reviews Gastroenterology and Hepatology, , - .
    • Calmont A, Thapar N, Scambler PJ, Burns AJ (). Absence of the vagus nerve in the stomach of Tbx1-/- mutant mice. Neurogastroenterology And Motility, , - .