Dr Nicolas Daudet

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Personal Profile

Name: Nicolas Daudet Email: n.daudet@ucl.ac.uk
Title: Dr Tel: 020 7679 8932
Department: The Ear Institute Fax: 020 7679 8990
Position: Senior Lecturer Address: UCL Ear Institute, 332 Gray's Inn Rd, London, WC1X 8EE
Research Domain: Communication, Language & Hearing, Neuroscience, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

In birds and cold-blood vertebrates, sensory hair cells of the inner ear spontaneously regenerate following tissue damage, but in mammals this ability has been lost. Why? And could we use regeneration in the human ear to treat certain forms of deafness?
Research in my lab focuses on the molecular mechanisms of sensory hair cell development and regeneration, and the roles of the Notch signalling pathway in these processes. Ongoing projects include the dynamic analysis of Notch activity during hair cell formation and regeneration in the chicken inner ear, and the identification of genes and signalling pathways interacting with Notch signalling during inner ear development.

Research Activities

Intracellular and intercellular signalling mechanisms in health and disease

Molecular mechanisms of inner ear development and regeneration

Education Description

UCL Collaborators

Dr Jonathan Gale; Prof Michael Duchen; Dr Sally Dawson

External Collaborators

Publications

    2014

    • Taylor R, Bullen A, Johnson SL, Grimm-Günter EM, Rivero F, Marcotti W, Forge A, Daudet N (2014). Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.. Hum Mol Genet, , - . doi:10.1093/hmg/ddu417

    2012

    • Freeman SD, Daudet N (2012). Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.. PLoS One, 7(10), e46387 - . doi:10.1371/journal.pone.0046387
    • Chrysostomou E, Gale JE, Daudet N (2012). Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition.. Development, 139(20), 3764 - 3774. doi:10.1242/dev.074476
    • Mistrík P, Daudet N, Morandell K, Ashmore JF (2012). Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter.. J Physiol, 590(Pt 22), 5597 - 5610. doi:10.1113/jphysiol.2012.241448
    • Freeman S, Chrysostomou E, Kawakami K, Takahashi Y, Daudet N (2012). Tol2-mediated gene transfer and in ovo electroporation of the otic placode: a powerful and versatile approach for investigating embryonic development and regeneration of the chicken inner ear.. Methods Mol Biol, 916, 127 - 139. doi:10.1007/978-1-61779-980-8_10

    2010

    • Bird JE, Daudet N, Warchol ME, Gale JE (2010). Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear.. J Neurosci, 30(37), 12545 - 12556. doi:10.1523/JNEUROSCI.3042-10.2010

    2009

    • Daudet N, Gibson R, Shang J, Bernard A, Lewis J, Stone J (2009). Notch regulation of progenitor cell behaviour in quiescent and regenerating auditory epithelium of mature birds.. Developmental Biology, Feb 1:326(1), 86 - 100. doi:10.1016/j.ydbio.2008.10.033
    • Freeman S, Daudet N (2009). The role of the transcription factor Sox21 in the developing chick inner ear. doi:10.1016/j.mod.2009.06.898
    • Chrysostomou E, Gale J, Daudet N (2009). Investigating the dynamics of Notch signalling in the embryonic chick inner ear using a reporter-based approach. doi:10.1016/j.mod.2009.06.594

    2007

    • Daudet N, Ariza-McNaughton L, Lewis J (2007). Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development, 134(12), 2369 - 2378. doi:10.1242/dev.001842

    2005

    • Daudet N, Lewis J (2005). Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation.. Development, 132(3), 541 - 551. doi:10.1242/dev.01589
    • Bermange A, Daudet N, Leslie J, Brooker R, Lewis J (2005). An early role for Notch signaling during development of the zebrafish inner ear..

    2002

    • Daudet N, Ripoll C, Moles JP, Rebillard G (2002). Expression of members of Wnt and Frizzled gene families in the postnatal rat cochlea.. Brain Res Mol Brain Res, 105(1-2), 98 - 107.
    • Daudet N, Ripoll C, Lenoir M (2002). Transforming growth factor-alpha-induced cellular changes in organotypic cultures of juvenile, amikacin treated rat organ of corti.. The Journal of Comparative Neurology, 442(1), 6 - 22. doi:10.1002/cne.1418
    • Daudet N, Lebart MC (2002). Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing autitory hair cells.. Cell Motility and the Cytoskeleton, 12(4), 326 - 336. doi:10.1002/cm.10092

    2000

    • Lenoir M, Daudet N, Parietti C, Humbert G, Ripoll C, Gallego M, Pujol R, Vago P (2000). [Regenerative potential in the organ of Corti after otic intoxication].. J Soc Biol, 194(3-4), 159 - 164.
    • Parietti C, Daudet N, Lenor M, Vago P (2000). Morphological and molecular changes in the mammalian cochlea after sensory hair cell losses (vol 42, pg 86, 2000). CYTOMETRY, 41(2), 152 - 152.

    1999

    • Lenoir M, Daudet N, Humbert G, Renard N, Gallego M, Pujol R, Eybalin M, Vago P (1999). Morphological and molecular changes in the inner hair cell region of the rat cochlea after amikacin treatment.. J Neurocytol, 28(10-11), 925 - 937.
    • Vago P, Parietti C, Daudet N, Humbert G, Gallégo M, Pujol R, Lenoir M (1999). [Regenerative potential of the sensory epithelium of the mammalian organ of Corti after poisoning with ototoxic antibiotics].. Morphologie, 83(262), 9 - 12.

    1998

    • Daudet N, Vago P, Ripoll C, Humbert G, Pujol R, Lenoir M (1998). Characterization of atypical cells in the juvenile rat organ of corti after aminoglycoside ototoxicity.. J Comp Neurol, 401(2), 145 - 162.