Prof Mark Lewis

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Personal Profile

Name: Mark Lewis Email: mark.lewis@ucl.ac.uk
Title: Prof Tel: 020 7915 1199
Department: Eastman Dental Institute Fax: 020 7915 1238
Position: Honorary Professor Address: 256 Grays Inn Road, , London, WC1X 8LD
Research Domain: Basic Life Sciences, Cancer, Experimental Medicine, Neuroscience, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

The research of my group falls within the remit of the Biomaterials and Tissue Engineering Divison and aims to both understand the underlying biology of regeneration and repair events and to generate approches for potential clinical intervention. We are particularly interested in the regeneration and repair of soft tissues involving the cellular reponse of myoblasts and fibroblasts and their interactions with their environment. This includes other cells (e.g. osteoblasts, keratinocytes), extracellular matrix and, highly topically, bioactive, biodegradable and biocompatible scaffolds for tissue engineering applications.My research now therefore follows the two general themes of REPAIR (fibroblasts) and REGENERATION (skeletal muscle). The REPAIR arm revolves around the function of fibroblasts in both normal and wounded oral mucosa and skin. My group has particularly concentrated on the biological signals that drive the fibroblast to myofibroblast transition; initially this was in 2D systems but we now routinely used 3D organotypic cultures to investigate the role of ECM receptors, proteases, cell interactions (with keratinocytes) and mechanical forces. The translational aspect of the work is encompassed with industrial collaborations regarding autologous cell transplantation of fibroblasts between different body sites. In addition, the 3D systems are proving amenable to manipulation in terms of study of oral cancer; this work is seeing most progress in the creation and validation of novel detection methods for normal and abnormal cells (dielectrophoresis). The REGENERATION arm concentrates on the basic structural and functional biology of skeletal muscle with special emphasis on the craniofacial jaw muscles. Our work has shown that the principle stimuli in this system is mechanical force as we now seek to dissect the molecular pathways that such stimulation activates. One such critical pathway is activation of proteases/integrins. Of great and topical interest are the continued application of cell biology knowledge to the formation of "tissue engineered" constructs and progenitor cells in these systems. Our work here looks to harness the power of precursor cells from skeletal muscle and to ultimately "engineer" a system with muscle correctly integrated with other musculoskeletal systems (bone, tendon, ligament) and the neural system. The translational aspect of this work aims to take the knowledge regarding muscle response to physical forces and apply this to dentofacial and other orthopeadic therapies to improve outcomes in terms of stability and success.

Research Activities

Regeneration and repair of soft tissue inc. mucosa and skeletal muscle

Education Description

?Faculty for the ?Modular training for the Bioprocess Industries (MBI)? training module ? Stem Cell and Regenerative Medicine Bioprocessing; UCL Biochemical Engineering.
? Project supervision in the Division of Surgery and Interventional Sciences: MSc in Tumour Biology, BSc (intercalated) Neurosciences, BSc Biomedical Sciences, BSc (intercalated) Orthopaedic Science, MSc Surgical Science, and MSc in Musculoskeletal Science.
?Faculty for MSc Orthodontics (UCL Eastman Dental Institute)
? Faculty for MClinDent Endodontics (UCL Eastman Dental Institute)
? Faculty for MSc Musculoskeletal Science (UCL Institute of Orthopaedic and Musculoskeletal Sciences, Division of Surgery and Interventional Sciences)
? Faculty for Diploma in Clinical Dental Sciences (UCL Eastman Dental Institute)
? Faculty for Diploma/Certificate in Restorative Dental Practice (UCL Eastman Dental Institute)

UCL Collaborators

Prof Pierre-Marc Bouloux; Dr Stefano Fedele; Dr Vivek Mudera

External Collaborators

Publications

    2013

    • Ödman AM, Hunt NP, Matloub Moawad HA, Sinanan ACM, Lewis MP, Kiliaridis S (2013). Molecular changes in detrained & retrained adult jaw muscle. European Journal of Orthodontics, 35(5), 659 - 663. doi:10.1093/ejo/cjs083
    • Shah R, Knowles JC, Hunt NP, Lewis MP (2013). Development of a novel smart scaffold for human skeletal muscle regeneration.. J Tissue Eng Regen Med, , - . doi:10.1002/term.1780
    • Sharples AP, Al-Shanti N, Hughes DC, Lewis MP, Stewart CE (2013). The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy. GROWTH HORMONE & IGF RESEARCH, 23(3), 53 - 61. doi:10.1016/j.ghir.2013.03.004
    • Mulhall HJ, Hughes MP, Kazmi B, Lewis MP, Labeed FH (2013). Epithelial cancer cells exhibit different electrical properties when cultured in 2D and 3D environments. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1830(11), 5136 - 5141. doi:10.1016/j.bbagen2013.07.008
    • Martin NRW, Passey SL, Player DJ, Khodabukus A, Ferguson RA, Sharples AP, Mudera V, Baar K, Lewis MP (2013). Factors affecting the structure and maturation of human tissue engineered skeletal muscle. Biomaterials, , - .
    • Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP (2013). Impaired hypertrophy in myoblasts is improved with testosterone administration. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 138, 152 - 161. doi:10.1016/j.jsbmb.2013.05.005

    2012

    • Sharples AP, Player DJ, Martin NRW, Mudera V, Stewart CE, Lewis MP (2012). Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs. Aging Cell, , - .
    • Shah R, Ready D, Knowles JC, Hunt NP, Lewis MP (2012). Sequential identification of a degradable phosphate glass scaffold for skeletal muscle regeneration.. J Tissue Eng Regen Med, , - . doi:10.1002/term.1581
    • Sculthorpe N, Solomon AM, Sinanan AC, Bouloux PM, Grace F, Lewis MP (2012). Androgens affect myogenesis in vitro and increase local IGF-1 expression.. Med Sci Sports Exerc, 44(4), 610 - 615. doi:10.1249/MSS.0b013e318237c5c0
    • Smith AS, Passey S, Greensmith L, Mudera V, Lewis MP (2012). Characterization and optimization of a simple, repeatable system for the long term in vitro culture of aligned myotubes in 3D.. J Cell Biochem, 113(3), 1044 - 1053. doi:10.1002/jcb.23437
    • Moawad HA, Sinanan ACM, Lewis MP, Hunt NP (2012). Grouping patients for masseter muscle genotype-phenotype studies. Angle Orthodontist, 82(2), 261 - 266. doi:10.2319/122810-750.1

    2011

    • Sharples AP, Al-Shanti N, Lewis MP, Stewart CE (2011). Reduction of Myoblast Differentiation Following Multiple Population Doublings in Mouse C2C12 Cells: A Model to Investigate Ageing?. JOURNAL OF CELLULAR BIOCHEMISTRY, 112(12), 3773 - 3785. doi:10.1002/jcb.23308
    • Kurtulus I, Kazmi B, Lewis MP, Solakoglu S, Schuster V, Scully C, Gokbuget A, Wahl G (2011). Altered functional activity patterns of fibroblasts related to periodontitis by systemic plasminogen deficiency (ligneous periodontitis). QUINTESSENCE INT, 42(7), 601 - 609.
    • Mulhall HJ, Labeed FH, Kazmi B, Costea DE, Hughes MP, Lewis MP (2011). Cancer, pre-cancer and normal oral cells distinguished by dielectrophoresis. ANAL BIOANAL CHEM, 401(8), 2455 - 2463. doi:10.1007/s00216-011-5337-0

    2010

    • Harzer W, Maricic N, Gedrange T, Lewis MP, Hunt NP (2010). Molecular diagnosis in orthodontics, facial orthopedics, and orthognathic surgery: implications for treatment progress and relapse. Seminars in Orthodontics, 16(2), 118 - 127.
    • Smith AST, Shah R, Hunt NP, Lewis MP (2010). The role of connective tissue and extracellular matrix signaling in controlling muscle development, function, and response to mechanical forces. Seminars in Orthodontics, 16(2), 135 - 142.
    • Carlqvist KH, Lewis MP, Hunt NP, Shah R (2010). Regeneration of jaw muscle - potential cellular mechanisms. Seminars in Orthodontics, 16(2), 147 - 152.
    • Retzepi M, Lewis MP, Donos N (2010). Effect of diabetes and metabolic control on de novo bone formation following guided bone regeneration.. Clin Oral Implants Res, 21(1), 71 - 79. doi:10.1111/j.1600-0501.2009.01805.x
    • Mudera V, Smith AS, Brady MA, Lewis MP (2010). The effect of cell density on the maturation and contractile ability of muscle derived cells in a 3D tissue-engineered skeletal muscle model and determination of the cellular and mechanical stimuli required for the synthesis of a postural phenotype.. J Cell Physiol, 225(3), 646 - 653. doi:10.1002/jcp.22271
    • Mulhall H, Patel M, Alqahtani K, Mason C, Lewis MP, Wall I (2010). Effect of capillary shear stress on recovery and osteogenic differentiation of muscle-derived precursor cell populations.. J Tissue Eng Regen Med, , - . doi:10.1002/term.355
    • Mulhall H, Patel M, Alqahtani K, Mason C, Lewis MP, WALL I (2010). Effect of capillary shear stress on recovery and osteogenic differentiation of muscle-derived precursor cell populations. J Tissue Eng Regen Med, , - . doi:10.1002/term.355
    • Shah R, Lewis MP (2010). The future? Craniofacial skeletal muscle engineering as an aid for the management of craniofacial deformities. Seminars in Orthodontics, 16(2), 153 - 162.
    • Retzepi M, Lewis MP, Donos N (2010). Effect of diabetes and metabolic control on de novo bone formation following guided bone regeneration. Clinical Oral Implants Research, 21(1), 71 - 79.

    2009

    • Kazmi B, Inglefield CJ, Lewis MP (2009). Autologous Cell Therapy: Current Treatments and Future Prospects. WOUNDS, 21(9), 234 - 242.
    • Lewis MP, Smith A, Shah R, Al-Qahtani K, Carlqvist K, Sinanan AC, Mudera V (2009). A little bit of this and a little bit of that! 3D tissue engineered skeletal muscle-Generating basic mechanisms in maintenance and turnover. doi:10.1016/j.cbpa.2009.04.034
    • Kayhanian H, Jones S, Phillips J, Lewis MP, Brown R, Mudera V (2009). Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs. Journal of Tissue Engineering and Regenerative Medicine, 3(1), 72 - 75. doi:10.1002/term.128
    • Suchak A, Hunt NP, Shah R, Sinanan ACM, Lloyd T, Lewis MP (2009). Myosin proteins identified from masseter muscle using quantitative reverse transcriptase-polymerase chain reaction - a pilot study of the relevance to orthodontics. European Journal of Orthodontics, 31(2), 196 - 201.
    • Proczek K, Lewis MP, Shah R, Hunt NP (2009). Importance of age in orthodontics: a study of craniofacial muscle maturation.
    • Kurtulus I, Kazmi B, Lewis MP, Solakoglu S (2009). Different functional activity pattern of fibroblasts from a case of ligneous periodontitis.
    • Wall IB, Bhadal N, Broad S, Whawell SA, Mudera V, Lewis MP (2009). Force generation and protease gene expression in organotypic co-cultures of fibroblasts and keratinocytes. Journal of Tissue Engineering and Regenerative Medicine, 3(8), 647 - 650. doi:10.1002/term.206
    • Retzepi M, Lewis MP, Donos N (2009). The effect of experimental diabetes and insulin therapy on guided bone regeneration.
    • Lewis MP, Mudera V, Cheema U, Shah R (2009). Muscle tissue engineering. In Meyer U, Meyer T, Handschel J, Wiesmann HP (Ed.), Fundamentals of Tissue Engineering and Regenerative Medicine (pp. 243 - 253). : Springer-Verlag.
    • Mudera V, Cheema U, Shah R, Lewis MP (2009). Improving biomaterials in tendon and muscle regeneration. In Di Silvio L (Ed.), Cellular Response to Biomaterials (pp. 237 - 251). : Woodhead Publishing Ltd..

    2008

    • Bitar M, Salih V, Knowles JC, Lewis MP (2008). Iron-phosphate glass fiber scaffolds for the hard-soft interface regeneration: the effect of fiber diameter and flow culture condition on cell survival and differentiation. Journal of Biomedical Materials Research Part A, 87(4), 1017 - 1026.
    • Kayhanian H, Jones S, Phillips J, Lewis MP, Mudera V (2008). Innervation and muscle cell infiltration of plastic compressed collagen constructs.
    • Mulhall HJ, Kazmi B, Labeed F, Hughes MP, Lewis MP (2008). The use of dielectrophoresis in oral cancer.
    • Tippett HL, Dodgson LK, Hunt NP, Lewis MP (2008). Indices of extracellular matrix turnover in human masseter muscles as markers of craniofacial form - a preliminary study. European Journal of Orthodontics, 30(2), 217 - 225.
    • Ödman AM, Hunt NP, Kiliaridis S, Matloub Moawad HA, Lewis MP (2008). Do masticatory functional changes influence masseter muscle of adult rats.
    • Shah R, Knowles JC, Hunt NP, Lewis MP (2008). Engineered craniofacial muscle constructs: another step towards implantable jaw muscle.
    • Abu-Maizar A, Hunt NP, Lewis MP (2008). Satellite cell activity in masseter muscle.
    • Bhadal N, Wall IB, Porter SR, Broad S, Lindahl GE, Whawell SA, Lewis MP (2008). The effect of mechanical strain on protease production by keratinocytes. British Journal of Dermatology, 158(2), 396 - 398.
    • Grant JER, Shah R, Lewis MP, Hunt NP (2008). Self-organizing human masseter muscle-derived constructs.
    • Ng JJ, Shah R, Ashley PF, Lewis MP (2008). Biodegradable scaffolds for pulp cell growth: pilot study.
    • Brady MA, Lewis MP, Mudera V (2008). Synergy between myogenic and non-myogenic cells in a 3D tissue-engineered craniofacial skeletal muscle construct. Journal of Tissue Engineering and Regenerative Medicine, 2(7), 408 - 417.
    • Sinanan ACM, Hunt NP, Lewis MP (2008). Ex vivo myogenesis of human adult masseter NCAM/CD56+ cells.
    • Retzepi M, Parkar MH, Wall I, Lewis MP, Donos N (2008). Genome wide pathway analysis of diabetes effect on osseous healing.
    • Kazmi B, Porter SR, Lewis MP (2008). Oral and dermal fibroblast organotypic co-cultures show differences in phenotype.
    • Sinanan ACM, Machell JRA, Wynne-Hughes GT, Hunt NP, Lewis MP (2008). Alphavbeta3 and alphavbeta 5 integrins and their role in muscle precursor cell adhesion. Biology of the Cell, 100(8), 465 - 477.
    • Carlqvist K, Brett PM, Lewis MP (2008). Craniofacial MDPCs could be used in clinical bone regeneration applications.
    • AlQahtani KM, Buxton PG, Parkar MH, Lewis MP (2008). Isolation of craniofacial muscle progenitor cells based on adhesion properties.
    • Hakim W, Smith A, Kazmi B, Kalmann B, Solomon A, Salih V, Greensmith L, Mudera V, Lewis MP (2008). Muscle-nerve interactions in chimaeric in vitro 3D collagen models.
    • Ashley PF, Kazmi B, Sivapragasam Y, Waddington RJ, Lewis MP (2008). Culturing human dental pulp explants in vitro.

    2007

    • Jones S, Morgan M, Lewis MP, Brown RA, Mudera V (2007). Innervation and muscle cell infiltrates in tissue-engineered collagen constructs in vivo.
    • McLoon LK, Thorstenson KM, Solomon A, Lewis MP (2007). Myogenic precursor cells in craniofacial muscles. Oral Diseases, 13(2), 134 - 140.
    • Solomon A, Sinanan ACM, Bouloux PMG, Lewis MP (2007). Effects of androgens on differentiation of human muscle-derived cells in vitro are related to changes in local IGF-1 expression.
    • Shah R, Hunt NP, Mudera V, Knowles JC, Lewis MP (2007). Novel glasses to engineer human craniofacial muscle.
    • Lygoe KA, Wall I, Stephens P, Lewis MP (2007). The role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation.. Biology of the Cell, 99(11), 601 - 614. doi:10.1042/BC20070008
    • Ng JJ, Shah R, Ashley PF, Lewis MP (2007). Culture of human dental pulp cells on glass fibre.
    • Campbell OJ, Shah R, Hunt NP, Lewis MP (2007). Expression of transglutaminases in human craniofacial skeletal muscle.
    • Kazmi B, Bhadal N, Wall I, Mudera V, Lewis MP (2007). Development of organotypic skin models to investigate the healing properties of oral and dermal fibroblasts.
    • Hakim W, Solomon A, Salih V, Mudera V, Lewis MP (2007). Muscle-nerve interactions in an in vitro 3D collagen gel model.
    • Grant JER, Shah R, Lewis MP, Hunt NP (2007). Self-organising human masseter muscle-derived constructs. doi:10.1093/ejo/cjm091
    • Lygoe KA, Wall I, Stephens P, Lewis MP (2007). Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biology of the Cell, 99(11), 601 - 614.
    • Ates K, Yang SY, Orrell RW, Sinanan AC, Simons P, Solomon A, Beech S, Goldspink G, Lewis MP (2007). The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle.. FEBS Letters, 581(14), 2727 - 2732.
    • Aggarwal S, Mudera V, Lewis MP (2007). In-situ differentiation of muscle derived cells under a mechanical stimulus.
    • Hunt NP, Shah R, Sinanan ACM, Lewis MP (2007). L'ingérence de la musculature dans les malocclusions: concepts actuels sur le rôle des muscles dans l'étiologie et le traitement de la malocclusion. Orthodontie Française, 78(2), 79 - 88. doi:10.1051/orthodfr:2007008
    • Broche LM, Bhadal N, Lewis MP, Porter SR, Hughes MP, Labeed FH (2007). Early detection of oral cancer - is dielectrophoresis the answer?. Oral Oncology, 43(2), 199 - 203.

    2006

    • Brady M, Brown RA, Mudera V, Lewis MP (2006). A new tissue engineered 3D-differentiated muscle model to investigate skeletal muscle plasticity.
    • Brady M, Brown R, Lewis MP, Mudera V (2006). Fusion of primary human skeletal muscle cells within a 3D-construct.
    • Suchak A, Hunt NP, Lewis MP, Sinanan ACM (2006). Vertical facial phenotype and gene expression in masseter muscle. doi:10.1093/ejo/cjl095
    • Hunt NP, Shah R, Sinanan ACM, Lewis MP (2006). Northcroft Memorial Lecture 2005. Muscling in on malocclusions: current concepts on the role of muscles in the aetiology and treatment of malocclusion. Journal of Orthodontics, 33(3), 187 - 197.
    • Hooper SJ, Crean SJV, Lewis MAO, Spratt DA, Wade WG, Wilson MJ (2006). Viable bacteria present within oral squamous cell carcinoma tissue. Journal of Clinical Microbiology, 44(5), 1719 - 1725.
    • Hodgson TA, Lewis NJ, Darbar UR, Welfare RD, Boulter A, Porter SR (2006). The short-term efficacy of osseointegrated implants in patients with non-malignant oral mucosal disease: a case series.
    • Sharwani A, Jerjes W, Hopper C, Lewis MP, El-Maaytah M, Khalil HSM, MacRobert AJ, Upile T, Salih V (2006). Photodynamic therapy down-regulates the invasion promoting factors in human oral cancer. Archives of Oral Biology, 51(12), 1104 - 1111. doi:10.1016/j.archoralbio.2006.05.012
    • (2006). Moving a 'head' with stem cells.
    • Khoshkhounejad G, Lewis MP, Hunt NP (2006). Contractile forces - an aid to formation of three-dimensional myotube cultures. doi:10.1093/ejo/cjl095
    • Brady M, Brown RA, Lewis M, Mudera V (2006). A New Tissue Engineered 3D-Differentiated Muscle Model to Investigate Skeletal Muscle Plasticity.
    • Campbell OJ, Lewis MP, Hunt NP, Shah RS (2006). Expression of transglutaminases in human craniofacial skeletal muscle. doi:10.1093/ejo/cjl095
    • Sinanan AC, Buxton PG, Lewis MP (2006). Muscling in on stem cells.. Biol Cell, 98(4), 203 - 214. doi:10.1042/BC20050050
    • Lewis N, Ready D, Howlett JA (2006). Culture dependant detection of Staphylococcus aureus in denture plaque.
    • Shah R, Ahmed I, Knowles JC, Hunt NP, Sinanan ACM, Lewis MP (2006). Novel scaffolds for tissue engineering of human skeletal muscles.
    • Sinanan ACM, Buxton PG, Lewis MP (2006). Muscling in on stem cells. Biology of the Cell, 98(4), 203 - 214.

    2005

    • Shah R, Knowles JC, Hunt NP, Lewis MP (2005). The engineering of human craniofacial muscle on a soluble glass fibre construct.
    • Lewis MP, Salih V, Knowles JC, Bitar M (2005). Biocompatible phosphate glass fibre scaffolds.
    • Sivapragasam Y, Lewis MP, Ashley PF (2005). In-vitro culture of human dental pulp cells (partial investigation).
    • Shah R, Sinanan ACM, Knowles JC, Hunt NP, Lewis MP (2005). Craniofacial muscle engineering using a 3-dimensional phosphate glass fibre construct. Biomaterials, 26(13), 1497 - 1505. doi:10.1016/j.biomaterials.2004.04.049
    • Ahmed I, Lewis MP, Knowles JC (2005). Quantification of anions and cations from ternary phosphate based glasses with fixed 50 and 55 mol% P2O5 using ion chromatography. Physics and Chemistry of Glasses, 46(6), 547 - 552.
    • Auluck A, Mudera V, Hunt NP, Lewis MP (2005). A three-dimensional in vitro model system to study the adaptation of craniofacial skeletal muscle following mechanostimulation. European Journal of Oral Sciences, 113(3), 218 - 224. doi:10.1111/j.1600-0722.2005.00215.x
    • Ahmed I, Lewis MP, Nazhat SN, Knowles JC (2005). Quantification of anion and cation release from a range of ternary phosphate-based glasses with fixed 45mol% P2O5. Journal of Biomaterials Applications, 20(1), 65 - 80.
    • Ahmed I, Lewis MP, Nazhat SN, Knowles JC (2005). Quantification of anion and cation release from a range of ternary phosphate-based glasses with fixed 45 mol% P2O5. J BIOMATER APPL, 20(1), 65 - 80. doi:10.1177/088532805049396
    • Abou Neel EA, Ahmed I, Blaker JJ, Bismarck A, Boccaccini AR, Lewis MP, Nazhat SN, Knowles JC (2005). Effect of iron on the surface, degradation and ion release properties of phosphate-based glass fibres. Acta Biomaterialia, 1(5), 553 - 563.
    • Bhadal N, Whawell SA, Lewis MP (2005). The effect of mechanical strain on plasminogen activator in skin keratinocytes.
    • Ahmed I, Lewis MP, Knowles JC (2005). Quantification of anions and cations from ternary phosphate based glasses with fixed 50 and 55 mol% P2O5 using ion chromatography. PHYS CHEM GLASSES, 46(6), 547 - 552.
    • Abou Neel EA, Ahmed I, Blaker JJ, Bismarck A, Boccaccini AR, Lewis MP, Nazhat SN, Knowles JC (2005). Effect of iron on the surface, degradation and ion release properties of phosphate-based glass fibres.. Acta Biomater, 1(5), 553 - 563. doi:10.1016/j.actbio.2005.05.001
    • Bhadal N, Whawell SA, Lewis MP (2005). The effect of mechanical strain on plasminogen activator in keratinocytes.
    • Bitar M, Salih V, Knowles JC, Lewis MP (2005). Phosphate-based glass fibre system: an inductive approach to bone-ligament interface repair.
    • Ahmed I, Lewis MP, Olsen I, Knowles JC (2005). Properties and structural characterisation of a range of ternary phosphate-based glasses and glass fibres.
    • Oliver S, Gulabivala K, Lewis MP (2005). Development of a protocol for in vitro culture of pulpal cells.
    • Brady M, Brown R, Lewis MP, Mudera V (2005). Mechanical behaviour of primary human skeletal muscle cells and isolated non-myogenic cells within a 3D- construct.
    • Bitar M, Knowles JC, Lewis MP, Salih V (2005). Soluble phosphate glass fibres for repair of bone-ligament interface. Journal of Materials Science: Materials in Medicine, 16(12), 1131 - 1136.

    2004

    • Ahmed I, Collins CA, Lewis MP, Olsen I, Knowles JC (2004). Processing, characterisation and biocompatibility of iron-phosphate glass fibres for tissue engineering. Biomaterials, 25(16), 3223 - 3232.
    • Ahmed I, Collins C, Olsen I, Lewis MP, Knowles JC (2004). Iron phosphate glass fibres for tissue engineering.
    • Sinanan ACM, Hunt NP, Lewis MP (2004). Human adult craniofacial muscle-derived cells: neural-cell-adhesion-molecule (NCAM; CD56)-expressing cells appear to contain multipotential stem cells. Biotechnology and Applied Biochemistry, 40(1), 25 - 34. doi:10.1042/BA20030185
    • Ahmed I, Collins C, Olsen I, Lewis MP, Knowles JC (2004). Iron-phosphate Glass Fibres for Tissue Engineering..
    • Lygoe KA, Speight PM, Lewis MP (2004). à5 integrin: its role in myofibroblast differentiation, contraction and migration.
    • Bitar M, Salih V, Mudera V, Knowles JC, Lewis MP (2004). Soluble phosphate glasses: in vitro studies using human cells of hard and soft tissue origin. Biomaterials, 25(12), 2283 - 2292. doi:10.1016/j.biomaterials.2003.08.054
    • Ahmed I, Lewis MP, Olsen I, Knowles JC (2004). Phosphate glasses for tissue engineering: Part 2. Processing and characterisation of a ternary-based P2O5-CaO-Na2O glass fibre system. Biomaterials, 25(3), 501 - 507.
    • Lygoe KA, Norman JT, Marshall JF, Lewis MP (2004). àv integrins play an important role in myofibroblast differentiation. Wound Repair and Regeneration, 12(4), 461 - 470.
    • Ahmed I, Lewis MP, Olsen I, Knowles JC (2004). Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5-CaO-Na2O glass system. Biomaterials, 25(3), 491 - 499.
    • Ahmed I, Collins C, Olsen I, Lewis MP, Knowles JC (2004). Phosphate-based glass fibres for tissue engineering applications.
    • Auluck A, Hunt NP, Lewis MP (2004). Adaptation of skeletal muscle connective tissue in response to stretch.
    • Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ (2004). Tumour-derived TGF-á1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. British Journal of Cancer, 90(4), 822 - 832. doi:10.1038/sj.bjc.6601611
    • Lygoe KA, Norman JT, Marshall JF, Lewis MP (2004). AlphaV integrins play an important role in myofibroblast differentiation.. Wound Repair and Regeneration, 12(4), 461 - 470.
    • Ahmed I, Collins C, Olsen I, Lewis MP, Knowles JC (2004). Phosphate-Based Glass Fibres for Tissue Engineering Applications..
    • Bitar M, Knowles JC, Salih V, Lewis MP (2004). Biocompatible phosphate glass fibre scaffolds. Engineering of the hard/soft tissue interface.
    • Thomas GJ, Lygoe KA, Nystrom ML, Speight PM, Lewis MP (2004). Tumour-derived TGF-beta 1 induces myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells.

    2003

    • Lygoe KA, Speight PM, Lewis MP (2003). Integrin involvement in myofibroblast differentiation of human gingival and human skin fibroblasts..
    • Ahmed I, Lewis MP, Olsen I, Knowles JC (2003). Processing, Characterisation and Biocompatibility of Iron-Phosphate Glass-Fibres for Tissue Engineering.
    • Lygoe KA, Speight PM, Lewis MP (2003). Integrin involvement in myofibroblast differentiation of human gingival and human skin fibroblasts.
    • Shah R, Hunt NP, Lewis MP (2003). Soluble phosphate-based glass fibres as a scaffold for regenerating masseter muscle.
    • Ahmed I, Knowles JC, Lewis MP (2003). Processing, characterisation and biocompatibility of iron phosphate glass fibres for tissue engineering.
    • Lewis MP, Dodgson L, Singh A, Hunt NP, Tippett HL (2003). Modification of craniofacial skeletal muscle regeneration by anti-proteases..
    • Lewis MP, Dodgson L, Singh A, Hunt NP, Tippett HL (2003). Modification of craniofacial skeletal muscle regeneration by anti-proteases.
    • Lewis MP, Lygoe KA, Nystrom ML, Speight PM, Thomas GJ (2003). Oral squamous cell carcinoma-derived TGF-á promotes myofibroblast differentiation and scatter-factor-dependent invasion.
    • Lewis MP, Lygoe KA, Nystrom ML, Speight PM, Thomas GJ (2003). Oral squamous cell carcinoma-derived TGF-beta promotes myofibroblast differentiation and scatter-factor-dependent invasion.. J DENT RES, 82, B112 - B112.

    2002

    • Wynne-Hughes GT, Hunt NP, Lewis MP (2002). The integrin surface receptor profile on human masseter muscle cell.
    • Dodgson LK (2002). In vivo expression of matrix metalloproteinases in human masseter muscle.
    • Bitar M, Ahmed I, Knowles JC, Salih V, Lewis MP (2002). Development of novel soluble glasses for tissue engineering of hard tissue.
    • Lewis MP (2002). Nucleus and gene expression. Current Opinion in Cell Biology, 3, 257 - 258.
    • Shah R, Knowles JC, Hunt NP, Lewis MP (2002). Human craniofacial skeletal muscle tissue engineering using a soluble glass fibre substrate.
    • Lewis MP (2002). Cell-to-cell contact and extracellular matrix. Current Opinion in Cell Biology, 5, 525 - 526.
    • Lewis MP (2002). Membranes and organelles. Current Opinion in Cell Biology, 4, 395 - 396.
    • Lewis MP (2002). Cell differentiation, cell division, growth and death. Current Opinion in Cell Biology, 6, 671 - 672.

    2001

    • Lewis MP, Sinanan ACM, Thomas GJ, Hunt NP, Tippett HL (2001). Cell-ECM interactions in human craniofacial myoblast migration.
    • Thomas GJ, Lewis MP, Hart IR, Marshall JF, Speight PM (2001). àVá6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9. International Journal of Cancer, 92(5), 641 - 650. doi:10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P
    • Thomas GJ, Lewis MP, Marshall JF, Speight PM (2001). αvβ6 integrin promotes invasion of squamous carcinoma cells through upregulation of MMP-9.
    • Thomas GJ, Poomsawat S, Lewis MP, Marshall JF, Speight PM (2001). alpha v beta 6-dependent upregulation of MMP-9 promotes keratinocyte migration.. J DENT RES, 80(4), 1155 - 1155.
    • Thomas GJ, Poomsawat S, Lewis MP, Hart IR, Speight PM, Marshall JF (2001). àvá6 integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes. Journal of Investigative Dermatology, 116(6), 898 - 904.
    • Wynne-Hughes GT, Hunt NP, Lewis MP (2001). Identification of integrin surface receptor proteins on human masseter muscle cell cultures.
    • Wynne-Hughes GT, Hunt NP, Lewis MP (2001). Integrin profile of human masseter muscle cell cultures.
    • Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF (2001). Expression of the àvá6 integrin promotes migration and invasion in squamous carcinoma cells. Journal of Investigative Dermatology, 117(1), 67 - 73. doi:10.1046/j.0022-202x.2001.01379.x
    • Shah B, Lewis MAO, Bedi R (2001). Oral submucous fibrosis in a 11-year-old Bangladeshi girl living in the United Kingdom. British Dental Journal, 191(3), 130 - 132.
    • Lewis MP, Machell JRA, Hunt NP, Sinanan ACM, Tippett HL (2001). The extracellular matrix of muscle - implications for manipulation of the craniofacial musculature. European Journal of Oral Sciences, 109(4), 209 - 221. doi:10.1034/j.1600-0722.2001.00021.x
    • Thomas GJ, Poomsawat S, Lewis MP, Marshall JF, Speight PM (2001). àvá6-dependent upregulation of MMP-9 promotes keratinocyte migration.

    2000

    • Lewis MP, Machell JRA, Wynne-Hughes GT, Whawell SA, Thomas GJ, Hunt NP, Sinanan ACM (2000). Cooperation between àná3 and àná5 integrin in human masseter muscle myoblast fusion.
    • Thomas GJ, Lewis MP, Marshall JF, Speight PM (2000). The role of àná 6 integrin in modulating epithelial cell behaviour.
    • Singh A, Nelson-Moon Z, Thomas GJ, Hunt NP, Lewis MP (2000). Identification of matrix metalloproteinases and their tissue inhibitors type 1 and 2 in human masseter muscle. Archives of Oral Biology, 45(6), 431 - 440.
    • Machell JRA, Hunt NP, Lewis MP (2000). The expression of alpha-v-integrin subunit in cultures of skeletal muscle cells.
    • Lewis MP, Tippett HL, Sinanan ACM, Morgan MJ, Hunt NP (2000). Gelatinase-B (matrix metalloproteinase-9; MMP-9) secretion is involved in the migratory phase of human and murine muscle cell cultures. Journal of Muscle Research and Cell Motility, 21(3), 223 - 233.
    • Thomas GJ, Lewis MP, Marshall JF, Speight PM (2000). The role of alpha nu beta 6 integrin in modulating epithelial cell behaviour.. J DENT RES, 79, 521 - 521.
    • Speight PM, Anderson WD, Whawell SA, Thomas GJ, Lewis MP (2000). à-smooth muscle actin induced in human oral fibroblasts by malignant epithelium.
    • Thomas GJ, Whawell SA, Lewis MP, Marshall JF, Speight PM (2000). αvβ6-dependent increase in MMP-9 secretion enhances keratinocyte migration.

    1999

    • Singh A, Hunt NP, Lewis MP (1999). In-vivo analysis of MMP and TIMP expression in human masseter muscle.
    • (1999). Response to an article by Hamilton et al. on 'Effects of colony stimulating factor-1 on human extravillous trophoblast growth and invasion'.
    • Lewis MP, Machell JRA, Thomas GJ, Whawell SA, Hunt NP (1999). The role of alpha-v integrins in masseter muscle myoblast migration and fusion.
    • Thomas GT, Lewis MP, Speight PM (1999). Matrix metalloproteinases and oral cancer. Oral Oncology, 35(3), 227 - 233.
    • Tippett HL, Madgwick AJA, Hunt NP, Lewis MP (1999). Characterisation of cell cultures from the human masseter muscle. British Journal of Orthodontics, 26(3), 175 - 177.
    • Norman J, Marshall J, Lewis M (1999). Co-ordination of renal fibrogenesis by collagen-binding integrins.
    • Thomas GJ, Lewis MP, Marshall JF, Speight PM (1999). The alpha-v beta-6 integrin modulates epithelial cell function: implications for wound healing and tumourigenesis.
    • Whawell SA, Thomas GJ, Lewis MP, Speight PM (1999). Increased invasion by alpha-v integrin expressing epithelial cells is mediated by plasminogen activators.

    1998

    • Price NL, Hunt NP, Lewis MP (1998). The expression of embryonic fibronectin splicing variants in human masseter muscle.
    • Thomas GJ, Lewis MP, Speight PM (1998). Regulation of matrix metalloproteinase (MMP) production by alpha-v integrins in oral carcinoma cell lines.
    • Thomas GJ, Lewis MP, Speight PM (1998). Alpha-v integrins mediate matrix metalloproteinase (MMP) production by oral epithelial cells on fibronectin.
    • Lewis MP, Norman JT (1998). Differential response of activated versus non-activated renal fibroblasts to tubular epithelial cells: a model of initiation and progression of fibrosis?. Experimental Nephrology, 6(2), 132 - 143.
    • Hunt NP, Nelson-Moon ZM, Tan IS, Lewis MP, Madgwick AJA (1998). Masseter muscle: an innocent victim or prime suspect in long face deformity?. doi:10.1093/ejo/20.4.463
    • Lewis MP, Hunt NP, Madgwick AJA, Tippett HL (1998). Regulation of MMPs/TIMPs in an in vitro model of human masseter muscle.
    • Price NL, Hunt NP, Lewis MP (1998). Expression of an embryonic fibronectin splicing variant in human masseter muscle. Archives of Oral Biology, 43(11), 911 - 915.
    • Thomas GJ, Lewis MP, Jones J, Speight PM (1998). Regulation of matrix metalloproteinase (MMP) production by integrin-ligand interactions in oral epithelial cells.

    1996

    • Brosens JJ, Takeda S, Acevedo CH, Lewis MP, Kirby PL, Symes EK, Krausz T, Purohit A, Gellersen B, White JO (1996). Human endometrial fibroblasts immortalized by simian virus 40 large T antigen differentiate in response to a decidualization stimulus. Endocrinology, 137(6), 2225 - 2231.
    • Lewis MP, Tan IS, Morgan MJ, Olsen I, Hunt NP (1996). Vertical facial deformity and extra-cellular matrix expression in masseter muscle.
    • Lewis MP, Fine LG, Norman JT (1996). Pexicrine effects of basement membrane components on paracrine signalling by renal tubular cells. Kidney International, 49(1), 48 - 58.
    • Norman JT, Lewis MP (1996). Matrix metalloproteinases (MMPs) in renal fibrosis. Kidney International, 49(Suppl. 54), S61 - S63.
    • Lewis MP, Clements M, Takeda S, Kirby PL, Seki H, Lonsdale LB, Sullivan MHF, Elder MG, White JO (1996). Partial characterization of an immortalised human trophoblase cell line, ICL-1, which possesses a CSF-1 autocrine loop. Placenta, 17, 137 - 146.

    1995

    • Norman JT, Gatti L, Wilson PD, Lewis M (1995). Matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases expression by tubular epithelia and interstitial fibroblasts in the normal kidney and in fibrosis. Experimental Nephrology, 3(2), 88 - 89.
    • NORMAN JT, LEWIS MP, FINE LG, ORPHANIDES C (1995). THE ROLE OF EXTRACELLULAR-MATRIX (ECM) AND GROWTH-FACTORS IN THE ACTIVATION OF RENAL FIBROBLASTS. J AM SOC NEPHROL, 6(3), 905 - 905.
    • LEWIS MP, FINE LG, NORMAN JT (1995). RAT RENAL FIBROBLASTS AND TUBULAR EPITHELIAL-CELLS BOTH PRODUCE ENZYMES THAT REGULATE MATRIX TURNOVER. KIDNEY INT, 47(2), 673 - 673.
    • LEWIS MP, NORMAN JT (1995). PRO-FIBROGENIC RELEVANCE OF EXPRESSION OF SMOOTH-MUSCLE ACTIN (SMA) BY RENAL FIBROBLASTS - CORRELATION WITH TISSUE INBIBITOR OF METALLOPROTEINASE-1 (TIMP-1) EXPRESSION. J AM SOC NEPHROL, 6(3), 899 - 899.

    1994

    • Lewis MP, Sullivan MHF, Elder MG (1994). Regulation by Interleukin-1á of growth and collagenase production by choriocarcinoma cells. Placenta, 15(1), 13 - 20.

    1993

    • Lewis MP, Morlese JF, Sullivan MHF, Elder MG (1993). Evidence for decidua-trophoblast interactions in early human pregnancy. Human Reproduction, 8(6), 965 - 968.

    • Suchak A, Hunt NP, Shah R, Sinanan ACM, Lloyd T, Lewis MP (). Myosin proteins identified from masseter muscle using quantitative reverse transcriptase polymerase chain reaction – a pilot study of relevance to orthodontics. European Journal of Orthodontics, , - .
    • Bitar M, Salih V, Knowles JC, Lewis MP (). Iron-phosphate glass fiber scaffolds for the hard-soft interface regeneration: The effect of fiber diameter and flow culture condition on cell survival and differentiation. Journal of Biomedical Materials Research Part A, , - .