Dr Matthew Piper


Personal Profile

Name: Matthew Piper Email: m.piper@ucl.ac.uk
Title: Dr Tel: 0207 679 2219
Department: Genetics, Evolution & Environment Fax:
Position: Senior Research Fellow Address: Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, London, WC1E 6BT
Research Domain: Ageing, Basic Life Sciences, Genetics (Frontier Disciplines), Personalised Medicine, Populations & Lifelong Health Web Page:  


Research Description

Dietary restriction (DR or calorie restriction) is an evolutionarily conserved intervention that extends healthy lifespan. I am interested in the nutrients and molecular mechanisms required to elicit this effect - in particular the role of protein. Knowledge of these interactions will aid our understanding of the role of nutrient balance in adult health, appetite and longevity.

Research Activities

Computer Vision

The role of nutrition in adult health and longevity

Education Description

3rd Year Biology of Ageing

UCL Collaborators

Dr Dorina Cadar; Dr Gabriel Brostow

External Collaborators

Dr Spencer Behmer; Prof Stephen Simpson; Dr Eric Blanc; Professor Linda Partridge; Dr Sebastian Gronke; Dr Carlos Ribeiro



    • Piper MD, Selman C, Speakman JR, Partridge L (2014). Using doubly-labeled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster.. J Genet Genomics, 41(9), 505 - 512. doi:10.1016/j.jgg.2014.07.004
    • Emran S, Yang M, He X, Zandveld J, Piper MD (2014). Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration.. Aging (Albany NY), 6(5), 390 - 398.


    • Piper MDW, He X, Niemeyer C, Kerr F, Blanc E, Leitão-Gonçalves R, Ribeiro C, Yang M, Hoddinott MP, Partridge L, Linford NJ, Hopfen C, Soultoukis GA, Pletcher SD (2013). A holidic medium for Drosophila melanogaster. Nature Methods, , - . doi:10.1038/nmeth.2731
    • Ziehm M, Piper MD, Thornton JM (2013). Analysing variation in Drosophila aging across independent experimental studies: a meta-analysis of survival data.. Aging Cell, 12(5), 917 - 922. doi:10.1111/acel.12123


    • Alic N, Hoddinott MP, Foley A, Slack C, Piper MD, Partridge L (2012). Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies.. PLoS One, 7(9), e45367 - . doi:10.1371/journal.pone.0045367


    • Piper MD, Partridge L, Raubenheimer D, Simpson SJ (2011). Dietary restriction and aging: a unifying perspective.. Cell Metab, 14(2), 154 - 160. doi:10.1016/j.cmet.2011.06.013
    • Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2011). Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.. Nature, 477(7365), 482 - 485. doi:10.1038/nature10296
    • Partridge L, Alic N, Bjedov I, Piper MD (2011). Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network.. Exp Gerontol, 46(5), 376 - 381. doi:10.1016/j.exger.2010.09.003
    • Kerr F, Augustin H, Piper MD, Gandy C, Allen MJ, Lovestone S, Partridge L (2011). Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease.. Neurobiol Aging, 32(11), 1977 - 1989. doi:10.1016/j.neurobiolaging.2009.10.015


    • Piper MD, Wong R, Grandison RC, Bass TM, Martinez PM, Partridge L (2010). Water-independent effects of dietary restriction in Drosophila.. Proc Natl Acad Sci U S A, 107(14), E54 - E56. doi:10.1073/pnas.0914686107


    • Grandison RC, Piper MD, Partridge L (2009). Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature, 462(7276), 1061 - 1064. doi:10.1038/nature08619
    • Iqbal A, Piper M, Faragher RG, Naughton DP, Partridge L, Ostler EL (2009). Chemical changes in aging Drosophila melanogaster. Age (Dordr.)., , - .
    • Wong R, Piper MD, Wertheim B, Partridge L (2009). Quantification of food intake in Drosophila. PLoS One., 4(6), e6063 - .
    • Grandison RC, Wong R, Bass TM, Partridge L, Piper MD (2009). Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster. PLoS One., 4(1), e4067 - .


    • Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ (2008). Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. The FASEB Journal, 22(3), 807 - 818.
    • Wong R, Piper MDW, Blanc E, Partridge L (2008). Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster. NAT METHODS, 5(3), 214 - 215. doi:10.1038/nmeth0308-213
    • Piper MD, Selman C, McElwee JJ, Partridge L (2008). Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?. J.Intern.Med., 263(2), 179 - 191.
    • Piper MD, Bartke A (2008). Diet and aging. Cell Metab., 8(2), 99 - 104.


    • Piper MD, Partridge L (2007). Dietary restriction in Drosophila: Delayed aging or experimental artefact?. PLoS.Genet., 3, e57 - .
    • Piper M, Mair W, Partridge L (2007). Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction". EXP GERONTOL, 42(4), 253 - 255. doi:10.1016/j.exger.2007.01.002
    • McElwee JJ, Schuster E, Blanc E, Piper MD, Thomas JH, Patel DS, Selman C, Withers DJ, Thornton JM, Partridge L, Gems DH (2007). Evolutionarily conservation of regulated longevity assurance mechanisms. Genome Biology, 8(7), R132 - . doi:10.1186/gb-2007-8-7-r132
    • Bass TM, Grandison RC, Wong R, Martinez P, Partridge L, Piper MD (2007). Optimization of dietary restriction protocols in Drosophila. J.Gerontol.A Biol.Sci.Med.Sci., 6, 1071 - 1081.
    • Boer VM, Tai SL, Vuralhan Z, Arifin Y, Walsh MC, Piper MDW, de Winde JH, Pronk JT, Daran JM (2007). Transcriptional responses of Saccharomyces cerevisiae to preferred and nonpreferred nitrogen sources in glucose-limited chemostat cultures. FEMS YEAST RES, 7(4), 604 - 620. doi:10.1111/j.1567-1364.2007.00220.x


    • Selman C, Kerrison ND, Cooray A, Piper MD, Lingard SJ, Barton RH, Schuster EF, Blanc E, Gems D, Nicholson JK, Thornton JM, Partridge L, Withers DJ (2006). Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiol Genomics, 27(3), 187 - 200.


    • Broughton SJ, Piper MD, Ikeya T, Bass TM, Jacobson J, Driege Y, Martinez P, Hafen E, Withers DJ, Leevers SJ, Partridge L (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.. Proceedings of the National Academy of Sciences of the United States of America, 102(8), 3105 - 3110.
    • Piper MDW, Selman C, McElwee JJP, L (2005). Models of insulin signalling and longevity.. Drug Discovery Today, 2, 249 - 256.
    • Piper MD, Mair W, Partridge L (2005). Counting the calories: the role of specific nutrients in extension of life span by food restriction. J Gerontol.A Biol Sci.Med.Sci., 60(5), 549 - 555.
    • Piper MDW, Skorupa DP, L (2005). Diet, metabolism and lifespan in Drosophila.. Experimental Gerontology, 40, 857 - 862.
    • Mair W, Piper MDWP, L (2005). Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biology, 3(e223), 0001 - 0007. doi:10.1371/journal.pbio.0030223


    • Partridge L, Piper MDW, and Mair W (2004). Dietary restriction in Drosophila.. Mechanisms of Ageing and Development, 126, 938 - 950.
    • van Maris AJA, Geertman JMA, Vermeulen A, Groothuizen MK, Winkler AA, Piper MDW, van Dijken JP, Pronk JT (2004). Directed evolution of pyruvate decarboxylase-negative Saccharomyces cerevisiae, yielding a C-2-independent, glucose-tolerant, and pyruvate-hyperproducing yeast. APPL ENVIRON MICROB, 70(1), 159 - 166. doi:10.1128/AEM.70.1.159-166.2004
    • Jansen MLA, Daran-Lapujade P, de Winde JH, Piper MDW, Pronk JT (2004). Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity. APPL ENVIRON MICROB, 70(4), 1956 - 1963. doi:10.1128/AEM.70.4.1956-1963.2004
    • Gelling CL, Piper MD, Hong SP, Kornfeld GD, Dawes IW (2004). Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae. J Biol Chem., 279(8), 7072 - 7081.


    • Daran-Lapujade P, Daran JM, Kotter P, Petit T, Piper MDW, Pronk JT (2003). Comparative genotyping of the Saccharomyces cerevisiae laboratory strains S288C and CEN.PK113-7D using oligonucleotide microarrays. FEMS YEAST RES, 4(3), 259 - 269. doi:10.1016/S1567-1356(03)00156-9
    • Lascaris R, Bussemaker HJ, Boorsma A, Piper M, van der Spek H, Grivell L, Blom J (2003). Hap4p overexpression in glucose-grown Saccharomyces cerevisiae induces cells to enter a novel metabolic state.. Genome Biol, 4(1), R3 - .
    • Boer VM, de Winde JH, Pronk JT, Piper MDW (2003). The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J BIOL CHEM, 278(5), 3265 - 3274. doi:10.1074/jbc.M209759200
    • Vuralhan Z, Morais MA, Tai SL, Piper MDW, Pronk JT (2003). Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae. APPL ENVIRON MICROB, 69(8), 4534 - 4541. doi:10.1128/AEM.69.8.4534-4541.2003


    • Piper MDW, Daran-Lapujade P, Bro C, Regenberg B, Knudsen S, Nielsen J, Pronk JT (2002). Reproducibility of oligonucleotide microarray transcriptome analyses - An interlaboratory comparison using chemostat cultures of Saccharomyces cerevisiae. J BIOL CHEM, 277(40), 37001 - 37008. doi:10.1074/jbc.M204490200
    • Piper MDW, Hong SP, Eissing T, Sealey P, Dawes IW (2002). Regulation of the yeast glycine cleavage genes is responsive to the availability of multiple nutrients. FEMS YEAST RES, 2(1), 59 - 71.


    • Piper MD, Hong SP, Ball GE, Dawes IW (2000). Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae.. J Biol Chem, 275(40), 30987 - 30995. doi:10.1074/jbc.M004248200


    • Hong SP, Piper MD, Sinclair DA, Dawes IW (1999). Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif.. J Biol Chem, 274(15), 10523 - 10532.