Dr Marilena Loizidou

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Personal Profile

Name: Marilena Loizidou Email: m.loizidou@ucl.ac.uk
Title: Dr Tel: 020 7794 0500 x 35575; x35303
Department: Research Department of Gen Surgery Fax:
Position: Senior Lecturer Address: Academic Department of Surgery, UCL Medical School, 9th floor, Royal Free Hospital, London, NW3 2QG
Research Domain: Cancer, Nanotechnology (Frontier Disciplines), Personalised Medicine Web Page:  

Profile

Research Description

COLORECTAL CANCER: We have delineated cellular and molecular mechanisms and mapped overexpression of a growth promoting peptide (Endothelin-1) and its receptor (Endothelin A receptor). We evaluated endothelin A receptor antagonism as a novel treatment agent and demostrated cancer killing. Agents (against endothelin A receptors) are being entered in clinical trials of patients with advanced colorectal cancer. The aim is to provide effective drug treatments for advanced colorectal cancer. MULTIDRUG RESISTANT CANCERS (breast and bladder): We have described a novel drug delivery system: photochemical internalisation of chemotherapy. This involves delivery of chemotherapeutics in an endosome whose membrane contains photodynamic agents. The latter are activated upon illumination resulting in the endosomal membrane bursting and chemotherapeutic agent delivered intracellularly. Other nanoscale drug delivery systems are also under investigation. The aim is to bypass drug-resistance which tends to develop in the majority of solid cancers. REGENERATIVE MEDICINE: We are constructing a nanopolymer based scaffold for the small intestine. The scaffold incorporates different cell types and will encourage nerve regeneration and the production of a blood supply. The ultimate aim is to tissue engineer tissue to treat small bowel syndrome.

Research Activities

Carbon nanotubes for the targeted delivery of chemotherapeutics to colorectal and breast cancer.

Experimental cancer therapeutics- ETAR antagonism, colorectal cancer

Gold Nanoparticles for the imaging of colorectal cancer using X-ray diffraction and fluorescence.

Mechanisms of tissue repair, scarring and fibrosis

Quantum Dots for dual imaging and delivery of therapy to colorectal cancer.

Education Description

CURRENT: (a) (Co)Creator and Tutor of the intercalated BSc in Surgical Sciences; (b)(Co)Creator and Tutor of the MSc in Nanotechnology and Regenerative Medicine; (c) Module Organiser for the MSc in Surgical Sciences PAST ACTIVITIES: (Co)Creator of the intercalated BSc in Tumour Biology

UCL Collaborators

Dr Jill Norman; Prof David Abraham; Prof Christopher Denton; Mr Olagunju Ogunbiyi; Prof Jim Owen; Miss Janice Tsui; Dr Hazel Welch; Dr Mick Dashwood; Prof Brian Davidson; Prof Alexander Seifalian; Dr Josephine Helen Woodhams

External Collaborators

Karen Lyons; Benoit De Crombrugghe; James Bonner; Kristofer Rubin; Thomas Kreig; Oliver Distler; Andrew Leask

Publications

    2014

    • Ricketts KP, Cheema U, Nyga A, Castoldi A, Guazzoni C, Magdeldin T, Emberton M, Gibson AP, Royle GJ, Loizidou M (2014). A 3D In Vitro Cancer Model as a Platform for Nanoparticle Uptake and Imaging Investigations.. Small, , - . doi:10.1002/smll.201400194
    • Rabadia H, Lopez-Devila V, Magdeldin T, Dashtarzheneh AK, Asger B, Kallis C, Dwek M, Welch H, Cheema U, Ramesh B, Loizidou M (2014). Testing the efficacy of targeted theranostic liposomes in in-vitro cancer models.
    • Haque SU, Welch H, Dashwood M, Ramesh B, Loizidou M (2014). Efficacy of Zibotentan in Colorectal Cancer-Response.. Mol Cancer Ther, , - . doi:10.1158/1535-7163.MCT-14-0002
    • Pradyumna D, Dashtarzheneh AK, Rabadia H, Asger BA, Magdeldin T, Lopez-Davila V, Ricketts K, Welch H, Loizidou M, Ramesh B (2014). Development of a novel 3D matrix for in vitro tumour model studies.

    2013

    • Lopez-Davila V, Welch H, Loizidou M (2013). Response of colorectal cancer cells to different MEK inhibitors.
    • Bovis MJ, Woodhams JH, Rojnik M, Kocbek P, Kos J, Bown SG, MacRobert AJ, Loizidou M (2013). M-THPC delivery via pegylated plga nanoparticles for in vivo photodynamic therapy (PDT).
    • Gan G, Roberts N, Lopez-Davila V, Loizidou M, Welch H (2013). Effective targeting of MEK (MAP kinase, kinase) in breast cancer cells.
    • Haque SU, Dashwood MR, Heetun M, Shiwen X, Farooqui N, Ramesh B, Welch H, Savage FJ, Ogunbiyi O, Abraham DJ, Loizidou M (2013). Efficacy of the specific endothelin A receptor antagonist zibotentan (ZD4054) in colorectal cancer: a preclinical study.. Mol Cancer Ther, , - . doi:10.1158/1535-7163.MCT-12-0975
    • Magdeldin T, Nyga A, Asghari A, Welch H, Loizidou M, Cheema U, Ricketts K, Gibson A, Royle G, Guazzoni C, Castolidi A, Montemurro G (2013). Imaging gold nanoparticles in a novel tissue engineered 3d in vitro cancer model.
    • Nagendran M, Gurusamy KS, Aggarwal R, Loizidou M, Davidson BR (2013). Virtual reality training for surgical trainees in laparoscopic surgery.. Cochrane Database Syst Rev, 8, CD006575 - . doi:10.1002/14651858.CD006575.pub3
    • Magdeldin T, Nyga A, Loizidou M, Cheema U (2013). 3D in vitro cancer model: A tissue engineering approach to cancer research.
    • Nyga A, Loizidou M, Emberton M, Cheema U (2013). A novel tissue engineered three-dimensional in vitro colorectal cancer model.. Acta biomaterialia, 9(8), 7917 - 7926.
    • Nyga A, Loizidou M, Emberton M, Cheema U (2013). A novel tissue engineered three-dimensional in vitro colorectal cancer model.. Acta Biomater, 9(8), 7917 - 7926. doi:10.1016/j.actbio.2013.04.028
    • Haque S-U, Welch H, Loizidou M (2013). Endothelin-1. Handbook of Biologically Active Peptides, , 512 - 518. doi:10.1016/B978-0-12-385095-9.00070-1

    2012

    • Knowles JP, Shi-Wen X, Haque SU, Bhalla A, Dashwood MR, Yang S, Taylor I, Winslet MC, Abraham DJ, Loizidou M (2012). Endothelin-1 stimulates colon cancer adjacent fibroblasts.. Int J Cancer, 130(6), 1264 - 1272. doi:10.1002/ijc.26090
    • Bovis MJ, Woodhams JH, Loizidou M, Scheglmann D, Bown SG, Macrobert AJ (2012). Improved in vivo delivery of m-THPC via pegylated liposomes for use in photodynamic therapy.. J Control Release, 157(2), 196 - 205. doi:10.1016/j.jconrel.2011.09.085
    • Haque S, Welch H, Loizidou M (2012). Cancer Peptides: Endothelin-1 Actions in Tumourigenesis. In Kastin AJ (Ed.), The Handbook of Biologically Active Peptides (pp. - ). : Academic Press.
    • López-Dávila V, Seifalian AM, Loizidou M (2012). Organic nanocarriers for cancer drug delivery.. Curr Opin Pharmacol, 12(4), 414 - 419. doi:10.1016/j.coph.2012.02.011
    • Ricketts K, Nyga A, Guazzoni C, Castoldi A, Magdeldin T, Montemurro G, Welch H, Cheema U, Royle G, Loizidou M (2012). Imaging Gold Nanoparticles in a Novel Tissue Engineered 3D in Vitro Cancer Model.
    • Castoldi A, Guazzoni C, Montemurro GV, Ricketts K, Royle G, Loizidou M, Cheema U, Nyga A, Bjeoumikhov A (2012). Theranostics imaging of tumours labelled with gold nanoparticles: Concept validation. IEEE Nuclear Science Symposium Conference Record, , 3778 - 3782. doi:10.1109/NSSMIC.2012.6551867
    • Adigbli DK, Seebaluk J, Macrobert AJ, Loizidou M (2012). Bioluminescence mediated photodynamic therapy in breast cancer cell line.
    • Goodyear G, Seebaluck J, Bartnik A, Loizidou M, Welch H (2012). Gene silencing reveals a role for oestrogen finger protein (EFP) in tamoxifen resistance.
    • Dashwood MR, Loizidou M (2012). Determination of cell-specific receptor binding using a combination of immunohistochemistry and in vitro autoradiography: relevance to therapeutic receptor targeting in cancer.. Methods Mol Biol, 878, 137 - 147. doi:10.1007/978-1-61779-854-2_9

    2011

    • Nyga A, Cheema U, Loizidou M (2011). 3D tumour models: novel in vitro approaches to cancer studies.. J Cell Commun Signal, 5(3), 239 - 248. doi:10.1007/s12079-011-0132-4
    • Gurusamy KS, Farooqui N, Loizidou M, Dijk S, Taanman JW, Whiting S, Farquharson MJ, Fuller BJ, Davidson BR (2011). Influence of zinc and zinc chelator on HT-29 colorectal cell line.. Biometals, 24(1), 143 - 151. doi:10.1007/s10534-010-9382-5
    • Gurusamy KS, Farooqui N, Loizidou MC, Dijk S, Taanman JW, Whiting S, Farquharson MJ, Fuller BJ, Davidson BR (2011). Influence of zinc and zinc chelator on HT-29 colorectal cell line. Biometals, 24(1), 143 - 151.
    • Haque S, Loizidou M, Shiwen X, Abraham D, Farooqui N, Welch H, Winslet M, Ogunbiyi O, Growcott J, Dashwood M (2011). Characterisation of endothelin-1 binding sites in colorectal cancer and antagonistic action of the endothelin a receptor antagonist zibotentan(ZD4054).
    • Haque S, Welch H, Dashwood M, Shiwen X, Abraham D, Heetun M, Farooqui N, Taylor I, Winslet M, Loizidou M (2011). Endothelin-1 stimulated gene induction within colorectal fibroblasts and the effect of endothelin receptor antagonism on key genes.
    • Bagnato A, Loizidou MC, Pflug B, Curwen J, Growcott J (2011). Role of the endothelin axis and its antagonists in the treatment of cancer. British Journal of Pharmacology, , - . doi:10.1111/j.1476-5381.2011.01217.x.
    • Yildirimer L, Thanh NTK, Loizidou M, Seifalian AM (2011). Toxicological considerations of clinically applicable nanoparticles. Nano Today, 6(6), 585 - 607.

    2010

    • Loizidou M, Seifalian AM (2010). Nanotechnology and its applications in surgery.. Br J Surg, 97(4), 463 - 465. doi:10.1002/bjs.7074
    • Haque S, Loizidou M, Shiwen X, Abraham D, Farooqui N, Welch H, Ogunbiyi O, Growcott J, Dashwood M (2010). Localisation and characterisation of ET-1 binding to human colorectal cancers and evaluation of the orally active ETA receptor antagonist zibotentan (ZD4054).
    • Gurusamy KS, Farooqui N, Loizidou M, Dijk S, Taanman JW, Whiting S, Farquharson MJ, Fuller BJ, Davidson BR (2010). Influence of zinc and zinc chelator on HT-29 colorectal cell line.
    • Heetun M, Haque S, Farooqui N, Dashwood M, Shiwen X, Abraham D, Winslet M, Loizidou M (2010). Efficacy of the specific ETA receptor antagonist zibotentan (ZD4054) in cancer cells and fibroblasts from colorectal cancer.
    • Pimenta D, Haque S, Heetun M, Dashwood M, Shiwen X, Farooqui N, Abraham D, Taylor I, Loizidou M (2010). The endothelin axis in drug sensitive and multidrug resistant bladder cancer cells.
    • Haque S, Loizidou M, Shiwen X, Abraham D, Farooqui N, Welch H, Ogunbiyi O, Growcott J, Dashwood M (2010). Localisation and characterization of ET-1 binding to human colorectal cancers and evaluation of the orally active ETA receptor antagonist Zibotentan (ZD4054).
    • Welch H, Harrison M, McCormack O, Loizidou M (2010). Deregulation of the oestrogen-finger protein EFP contributes to hormone-independent growth of breast tumours.
    • Welch HM, Harrison M, McCormack O, Gallagher E, McGoldrick A, Chung W, Cooke F, Kerin M, Dervan P, Winslet M, Loizidou M (2010). Deregulation of the oestrogen-finger protein EFP contributes to hormone-independent growth of breast tumours.

    2009

    • Heetun M, Haque S, Loizidou M (2009). p53 at a Glance: The Story so Far. Oncology News, 4(2), 49 - 51.
    • Haque S, Heetun M, Taylor I, Shiwen X, Winslet M, Loizidou M (2009). Efficacy of the Specific ETA Receptor Antagonist Zibotentan in Colorectal Cancer Cells and Colorectal Fibroblasts.
    • Bhalla A, Haque S, Taylor I, Winslet M, Loizidou M (2009). Endothelin receptor antagonism and cancer. European Journal of Clinical Investigation, 39, 74 - 77.
    • Gurusamy KS, Aggarwal R, Palanivelu L, Davidson BR (2009). Virtual reality training for surgical trainees in laparoscopic surgery. Cochrane Database of Systematic Reviews, (1), CD006575 - . doi:10.1002/14651858.CD006575.pub2
    • Wright KE, Liniker E, Loizidou M, Moore C, MacRobert AJ, Phillips JB (2009). Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model. British Journal of Cancer, 101(4), 658 - 665.
    • Pimenta D, Haque S, Heetun M, Dashwood M, Shiwen W, Farooqui N, Abraham D, Loizidou M (2009). The Endothelin Axis in Drug Sensitive and Multidrug Resistant Bladder Cancer Cells.
    • Malam Y, Loizidou M, Seifalian AM (2009). Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol.Sci., 30(11), 592 - 599.

    2008

    • Loizidou M (2008). Endothelin-1 promoting actions in the growth and angiogenesis of solid cancers.. In Black C, Dashwood M, Abraham D (Ed.), Vascular complications of human disease: Mechanisms and consequences (pp. 187 - 196). : .
    • Yang SY, Sales KM, Loizidou M, Winslet M (2008). Colorectal cancer: Chemotherapy resistance, apoptosis and future directions in therapy.. , 3(1), 20 - 21.
    • Sousi E, Adigbli DK, Wilson DG, Farooqui N, Taylor I, Loizidou M (2008). Photochemical internalisation potentiates the killing of multi-drug resistant cancer cells without any change in the function of P-GP drug-efflux pumps. Colorectal Disease, 10, 2 - .

    2007

    • Sousi E, Farooqui N, Taylor I, MacRobert A, Loizidou M (2007). Circumvention of multi-drug resistance using photochemical internalisation of chemotherapy.
    • Loizidou M, Hoosein M, Knowles J, Xu S, Grigoriades A, Dashwood M, Abraham D, Taylor I (2007). ET-1 promotes desmoplasia in human colorectal fibroblasts.
    • Adigbli DK, Wilson DGG, Loizidou M (2007). Genetic Events Underlying Colorectal Carcinogenesis. Oncology News, 2(1), 20 - 22.
    • Grant K, Knowles J, Dawas K, Burnstock G, Taylor I, Loizidou M (2007). Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines. British Journal of Surgery, 94(1), 106 - 112. doi:10.1002/bjs.5536
    • Wilson D, Adigbli D, Macrobert A, Risley P, Loizidou M (2007). Photochemical internalization of chemotherapy increases killing of multidrug resistant cancer cells..
    • Hoosein MM, Dashwood MR, Dawas K, Ali HMMDA, Grant K, Savage F, Taylor I, Loizidou M (2007). Altered endothelin receptor subtypes in colorectal cancer. European Journal of Gastroenterology and Hepatology, 19(9), 775 - 782. doi:10.1097/MEG.0b013e3282c563de
    • Adigbli DK, Wilson DGG, Farooqui N, Risley P, Taylor I, MacRobert AJ, Loizidou M (2007). Photochemical internalisation of chemotherapy potentiates killing of multidrug resistant breast and bladder cancer cells.. British Journal of Cancer, 97(4), 507 - 512. doi:10.1038/sj.bjc.6603895
    • Grant K, Taylor I, Loizidou M (2007). Cancer Peptides: Endothelin-1. In Kastin A (Ed.), The Handbook of Biologically Active Peptides (pp. 447 - 452). : .
    • Hoosein MM, Taylor I, Loizidou M (2007). Role of the endothelin axis in colorectal cancer. Oncology News, 2(4), 15 - 17.

    2006

    • Knowles J, Loizidou M, Dashwood M, Abraham D, Xu S, Taylor I (2006). Endothelin-1 stimulates colorectal cancer adjacent-fibroblasts. European Journal of Surgical Oncology, 32, 54 - .
    • Stubbs B, Loizidou M, Falzon M, Douek M (2006). Are angiogenesis and lymphangiogenesis correlated with lynph node metastases in breast cancer?.
    • Chamary VL, Loizidou M, Boulos PB, Burnstock G (2006). Changes in vasoconstrictor and vasodilator neurotransmitters in nerves supplying arterioles in developing colorectal polyps. Colorectal Disease, 8(3), 230 - 234.
    • Grant K, Loizidou M, Taylor I (2006). Endothelin. Handbook of Biologically Active Peptides, , 447 - 452. doi:10.1016/B978-012369442-3/50067-2
    • Stubbs B, Douek M, Loizidou M, Hall-Craggs M, Usiskin S, Falzon M (2006). Evaluating the role of breast cancer angiogenesis and lymphangiogenesis on dynamic contrast enhanced MRI.
    • Wilson DG, Macrobert A, Adigbli D, Risley P, Taylor I, Loizidou M (2006). Photochemical internalisation of chemotherapeutic drugs enhances killing of resistant cancer cells.
    • Knowles J, Loizidou M, Abrahams D, Dashwood M, Xu S, Taylor I (2006). Endothelin-1 influences desmoplasia in colorectal cancer.

    2005

    • Pakzad F, Loizidou M, Ell PJ, Taylor I (2005). Measuring early adaptive response to 5-fluorocil therapy using FLT-positron emission tomography. British Journal of Surgery, 92(10), 1304 - 1304.
    • Adigbli D, MacRobert A, Loizidou M (2005). Photochemical internalization of chemotherapeutic agents to circumvent multidrug resistance. Ejc Supplements, 3(2), 431 - 431.
    • Pakzad F, Loizidou M, Ell PJ, Taylor I (2005). Activation of thymidine salvage pathway measured with FLT PET, as a potential indicator of response to 5FU in colorectal cancer. Journal of Clinical Oncology, 23(16), 264S - 264S.
    • Knowles J, Loizidou M, Taylor I (2005). Endothelin-1 and angiogenesis in cancer. Current Vascular Pharmacology, 3(4), 309 - 314.
    • Pakzad F, Loizidou M, Ell PJ, Taylor I (2005). An assessment of cellular response to 5-fluorouracil FLT positron emission tomography. British Journal of Surgery, 92, 87 - 88.

    2004

    • Hoosein MM, Dashwood M, Grant K, Savage F, Loizidou M, Taylor I (2004). Endothelin receptor profiles in colorectal cancer. British Journal of Surgery, 91(9), 1231 - 1231.
    • Francis DL, Loizidou M, Visvikis D, De Vos S, Luthra S, Taylor I, Ell P (2004). Assessing response to 5FU chemotherapy using a new PET tracer: FLT.

    2003

    • Francis DL, Loizidou M, Visvikis D, De Vos S, Luthra SK, Taylor I, Ell PJ (2003). Monitoring 5FU chemotherapy response in colorectal cancer using PET.
    • Linn TY, Loizidou M, Savage F, Taylor I (2003). Modulation of colorectal cancer cell adhesion by Endothelin-1.
    • Grant K, Loizidou M, Taylor I (2003). Endothelin 1: A multifunctional molecule in cancer. British Journal of Cancer, 88(2), 163 - 166.
    • Hoosein M, Dashwood M, Grant K, Savage F, Loizidou M, Taylor I (2003). Endothelin receptor expression in human colorectal cancer.
    • Grant K, Loizidou M, Taylor I (2003). The mitogenic mechanisms of endothelin-1 in colorectal cancer. British Journal Of Surgery, 90(5), 604 - 604.

    2002

    • Grant K, Loizidou M, Farooqui N, Taylor I (2002). The mitogenic mechanisms of endothelin-1 in colorectal cancer.
    • Aliev G, Smith MA, Seyidova D, Neal ML, Shi J, Loizidou M, Turmaine M, Friedland RP, Taylor I, Burnstock G, Perry G, Lamanna JC (2002). Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium. Journal of Submicroscopic Cytology and Pathology, 34(1), 37 - 50.
    • Xu W, Liu LZ, Loizidou M, Ahmed M, Charles IG (2002). The role of nitric oxide in cancer. Cell Research, 12(5-6), 311 - 320.
    • Francis DL, Arulampalam THA, Visvikis D, Costa DC, Ell PJ, Taylor I (2002). Whole body FDG-pet for surgical staging of colorectal liver metastases.
    • Arulampalam THA, Costa DC, Loizidou M, Ell PJ, Taylor I (2002). PET for the evaluation of colorectal liver metastases.
    • Arulampalam THA, Costa DC, Visvikis D, Loizidou M, Ell PJ, Taylor I (2002). Preoperative evaluation of colorectal liver metastases using positron emission tomography. British Journal of Surgery, 89(5), 647 - 648.
    • Taylor I, Arulampalam THA, Costa DC, Loizidou M, Ell PJ (2002). Positron emission tomography for the evaluation of colorectal cancer metastases.

    2001

    • Arulampalam THA, Costa DC, Loizidou M, Boulos PB, Ell PJ, Taylor I (2001). The use of PET for the evaluation of recurrent or metastatic colorectal cancer. British Journal Of Surgery, 88(s1), 56 - 56.
    • Asham E, Shankar A, Loizidou M, Fredericks S, Miller K, Boulos PB, Burnstock G, Taylor I (2001). Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ETA receptor antagonism. BRIT J CANCER, 85(11), 1759 - 1763. doi:10.1054/bjoc.2001.2193
    • Arulampalam THA, Costa DC, Bomanji J, Loizidou M, Boulos PB, Ell PJ, Taylor I (2001). The use of PET for the evaluation of recurrent or metastatic colorectal cancer. doi:10.1111/j.1463-1318.2001.00001.x
    • Asham E, Shankar A, Loizidou M, Fredericks S, Miller K, Boulos PB, Burnstock G, Taylor I (2001). Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ETA receptor antagonism. British Journal of Cancer, 85(11), 1759 - 1763. doi:10.1054/bjoc.2001.2193
    • Arulampalam THA, Costa DC, Loizidou M, Ell PJ, Taylor I (2001). Positron emission tomography for the evaluation of colorectal liver metastases.
    • Arulampalam THA, Costa DC, Bomanji JB, Loizidou M, Taylor I, Ell PJ (2001). The role of PET in colorectal cancer management.
    • Arulampalam THA, Costa DC, Loizidou M, Visvikis D, Ell PJ, Taylor I (2001). Positron emission tomography and colorectal cancer. British Journal of Surgery, 88(2), 176 - 189.
    • Arulampalam THA, Costa DC, Loizidou M, Vaizey CJ, Boulos PB, Ell PJ, Taylor I (2001). Does PET have a role in staging colorectal cancer?.
    • Arulampalam THA, Costa DC, Bomanji JB, Loizidou M, Ell PJ, Taylor I (2001). The utility of PET for assessing patients with colorectal liver metastases.
    • Arulampalam THA, Costa DC, Loizidou M, Boulos PB, Ell PJ, Taylor I (2001). The use of PET for the evaluation of recurrent or metastatic colorectal cancer.
    • Arulampalam THA, Costa DC, Bomanji J, Loizidou M, Ell PJ, Taylor I (2001). The utility of PET for assessing patients with colorectal liver metastases.
    • Arulampalam THA, Costa DC, Bomanji JB, Loizidou M, Boulos PB, Ell PJ, Taylor I (2001). The use of PET for the evaluation of recurrent or metastatic colorectal cancer.
    • Arulampalam THA, Costa DC, Loizidou M, Vaizey CJ, Boulos PB, Ell PJ, Taylor I (2001). Does PET have a role in staging primary colorectal cancer?.
    • Arulampalam THA, Costa DC, Bomanji J, Loizidou M, Taylor I, Ell PJ (2001). The role of PET in colorectal cancer management.

    2000

    • Ali H, Dashwood M, Dawas K, Loizidou M, Savage F, Taylor I (2000). Endothelin receptor expression in colorectal cancer. Journal of Cardiovascular Pharmacology, 36(5 Supp), S69 - S71.
    • Dawas K, Dashwood M, Loizidou M, Ali H, Burnstock G, Taylor I (2000). Expression of endothelin receptors in human colorectal liver metastases.
    • Dawas K, Dashwood M, Loizidou M, Ali H, Burnstock G, Taylor I (2000). Expression of endothelin receptors in human colorectal liver metastases.
    • Arulampalam THA, Lovett B, Loizidou M, Costa DC, Boulos PB, Ell PJ, Taylor I (2000). The role of positron emission tomography in the management of recurrent colorectal cancer.
    • Dawas K, Loizidou M, Rubin T, Ali H, Burnstock G, Taylor I (2000). Endothelin ETA receptor antagonism decreases colorectal cancer cell growth.
    • (2000). Endothelin receptor expression in colorectal cancer. Journal of Cardiovascular Pharmacology, 36 (Su, S69 - S71.
    • (2000). Recent trials in colorectal cancer. Colorectal Disease, 2, 45 - 49.
    • Ali H, Loizidou M, Dashwood M, Savage F, Sheard C, Taylor I (2000). Stimulation of colorectal cancer cell line growth by ET-1 and its inhibition by ETA antagonists. Gut, 47(5), 685 - 688.
    • Chamary VL, Robson T, Loizidou M, Boulos PB, Burnstock G (2000). Progressive loss of perivascular nerves adjacent to colorectal cancer. European Journal of Surgical Oncology, 26(6), 588 - 593.

    1999

    • Ali H, Loizidou M, Dashwood M, Savage F, Boulos PB, Taylor I (1999). Endothelin receptor expression in colorectal cancer. British Journal of Cancer, 80, 91 - 91.
    • Asham EH, Loizidou M, Burnstock G, Taylor I (1999). The effect of endothelin-1 antagonism on tumour development.
    • Chamary VL, Belai A, Loizidou M, Jordan R, Boulos PB, Taylor I, Burnstock G (1999). Perivascular innervation of submucosal arterioles of colonic polyps. Gut, 44, A141 - A141.
    • Shankar A, Loizidou M, Burnstock G, Taylor I (1999). Noradrenaline improves the tumour to normal blood flow ratio and drug delivery in a model of liver metastases. BRIT J SURG, 86(4), 453 - 457.
    • Dawas K, Loizidou M, Shankar A, Ali H, Taylor I (1999). Angiogenesis in cancer: the role of endothelin-1. Annals of the Royal College of Surgeons of England, 81(5), 306 - 310.
    • Davies CL, Loizidou M, Cooper AJ, Taylor I (1999). Effect of gamma-linoleic acid on cellular uptake of structurally related anthrocylclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines. European Journal of Cancer, 35(10), 1534 - 1540.
    • Shankar A, Loizidou M, Burnstock G, Taylor I (1999). Noradrenaline improves the tumour to normal blood flow ratio and drug delivery in a model of liver metastases. British Journal of Surgery, 86(4), 453 - 457.
    • Dawas K, Loizidou M, Rickin T, Ali H, Burnstock G, Taylor I (1999). Endothelin E T A receptor antagonism decreases colorectal cancer cell growth.
    • Ali H, Loizidou M, Dashwood M, Savage F, Boulos PB, Taylor I (1999). Endothelin receptor expression in colorectal cancer.
    • Dawas K, Loizidou M, Shankar A, Ali H, Taylor I (1999). Angiogenesis in cancer: the role of endothelin-1.. Ann R Coll Surg Engl, 81(5), 306 - 310.

    1998

    • Shankar A, Loizidou M, Taylor I (1998). The role of Endothelin-1 in colorectal malignancy. Cancer Topics, 10(9), 10 - 12.
    • Shankar A, Loizidou M, Aliev G, Fredericks S, Holt D, Boulos PB, Burnstock G, Taylor I (1998). Raised endothelin 1 levels in patients with colorectal liver metastases.
    • Ali H, Loizidou M, Sheard C, Grigoropoulos N, Savage F, Dawas K, Boulos PB, Taylor I (1998). Endothelin receptors are up-regulated in colorectal cancer.
    • Chamary V, Robson T, Loizidou M, Boulos PB, Taylor I, Burnstock G (1998). Loss of perivascular nerves in the submucosa adjacent to colorectal cancer.
    • Asham EH, Loizidou M, Taylor I (1998). Endothelin-1 and tumour development. European Journal of Surgical Oncology, 24(1), 57 - 60.
    • Shankar A, Loizidou M, Aliev G, Fredericks S, Boulos PB, Holt D, Burnstock G, Taylor I (1998). Raised endothelin-1 levels in patients with colorectal liver metastases. British Journal of Surgery, 85(4), 502 - 506.
    • Chong IYS, Bradley V, Davies C, Loizidou M, Cooper AJ, Taylor I (1998). Drug resistance evaluation by functional assay and immunofluorescence in bladder cancer. British Journal of Surgery, 85(5), 710 - 710.

    1997

    • Ashraf S, Loizidou M, Crowe R, Turmaine M, Taylor I, Burnstock G (1997). Blood vessels in liver metastases from both sarcoma and carcinoma lack perivascular innervation and smooth muscle cells.. Clin Exp Metastasis, 15(5), 484 - 498.
    • Shankar A, Loizidou M, Burnstock G, Taylor I (1997). Vasoconstrictors improve delivery of hepatic arterial 5-flourouracil in a model of colorectal liver metastases.
    • Kuruppu D, Christophi C, O'Brien PE, Jeppsson B, Loizidou M, Taylor I (1997). Microvascular architecture of hepatic metastases in a mouse model. HPB Surgery, 10(3), 149 - 158.
    • Loesch A, Turmaine M, Loizidou M, Crowe R, Ashraf S, Taylor I, Burnstock G (1997). Increase in immunoreactivity for endothelin-1 in blood vessels of rat liver metastases: experimental sarcoma and carcinoma. Journal of Anatomy, 191(Pt 2), 291 - 299.
    • Ashraf S, Loizidou M, Crowe R, Turmaine M, Taylor I, Burnstock G (1997). Blood vessels in liver metastases from both sarcoma and carcinoma lack perivascular innervation and smooth muscle cells. Clinical and Experimental Metastasis, 15(5), 484 - 498. doi:10.1023/A:1018466608614
    • Asham E, Shankar A, Frederick S, Miller K, Loizidou M, Holt D, Burnstock G, Taylor I (1997). Production and secretion of endothelin 1 in colorectal cancer.

    1996

    • Loizidou MC, Carpenter R, Laurie H, Alexander P, Taylor I (1996). Growth enhancement of implanted human colorectal cancer cells by the addition of fibroblasts in vivo. British Journal of Surgery, 83(1), 24 - 28.
    • Shankar A, Loizidou M, Taylor I (1996). The vascularity of colorectal liver metastases. European Journal of Surgical Oncology, 22(4), 389 - 396.
    • Shankar A, Loizidou M, Taylor I (1996). The vascularity of colorectal liver metastases.. Eur J Surg Oncol, 22(4), 389 - 396.
    • Ashraf S, Crowe R, Loizidou MC, Turmaine M, Taylor I, Burnstock G (1996). The absence of autonomic perivascular nerves in human colorectal liver metastases. British Journal of Cancer, 73(3), 349 - 359.
    • Davies CL, Duffy PM, MacRobert AJ, Loizidou MC, Cooper AJ, Taylor I (1996). Localization of anthracycline accumulation in sensitive and resistant urothelial tumor cell lines. Cancer Detection and Prevention, 20(6), 625 - 633.

    1995

    • Ashraf S, Crowe R, Loizidou MC, Turmaine M, Taylor I, Burnstock G (1995). Blood-Vessels in Colorectal Liver Metastases Are Not Innervated. British Journal of Surgery, 82(5), 706 - 706.
    • Davies CL, MacRobert AJ, Loizidou M, Cooper A, Mudan S, Taylor I (1995). Comparison of Anthracycline Uptake in Sensitive and Drug-Resistant Tumor-Cells. British Journal of Surgery, 82(5), 704 - 704.

    1994

    • Schumacher U, Higgs D, Loizidou M, Pickering R, Leathem A, Taylor I (1994). Helix-Pomatia Agglutinin Binding Is A Useful Prognostic Indicator in Colorectal-Carcinoma. Cancer, 74(12), 3104 - 3107.

    1992

    • Hind R, Loizidou M, Fleming J, Taylor I (1992). Biodistribution of lipiodol following hepatic arterial injection. British Journal of Surgical Oncology, 18, 162 - 167.
    • Francis J, Carty N, Amirkhosravi M, Loizidou M, Cooper A, Taylor I (1992). The effect of warfarin and factor VII on tissue procoagulant activity and metastases. British Journal of Cancer, 65, 329 - 334.
    • Hind R, Loizidou M, Perring S, Fleming J, Batty V, Birch S, Taylor I (1992). Biodistribution of lipiodol following hepatic arterial injection in patients with colorectal hepatic metastases. British Journal of Surgery, 79, 952 - 954.
    • Hind RE, Loizidou M, Perring S, Fleming J, Batty V, Birch S, Taylor I (1992). Biodistribution of Lipiodol following hepatic arterial injection. British Journal of Surgery, 79(9), 952 - 954. doi:10.1002/bjs.1800790933

    1991

    • Loizidou M, Lawrance R, Holt S, Cooper A, Alexander P, Taylor I (1991). Facilitation by partial hepatectomy of tumour growth within the rat liver following intraportal injection of syngeneic tumour cells. Clinical and Experimental Metastasis, 9(4), 335 - 349.
    • Lawrance R, Loizidou C, A A, P T, I (1991). Importance of the omentum in the development of intra-abdominal metastases. British Journal of Surgery, 78, 117 - 119.
    • Theocharis S, Margeli A, Fasitsas C, Loizidou M, Deliconstantinos G (1991). Acute exposure to cadmium causes time-dependent liver injury in rats. Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, 99(1-2), 127 - 130.
    • Sonnenberg A, Janssen H, Daams H, Van Der Raaij-Helmer LMH, Falcioni R, Kennel SJ, Aplin JD, Baker J, Garrod D, Loizidou M, Calafat J (1991). Integrin α6/β4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. Journal of Cell Biology, 113(4), 907 - 917.

    1990

    • Hunt T, Loizidou M, Britten A, Fleming J, Taylor I (1990). Do changes in liver blood flow correlate with the extent of replacement by liver metastases?. Surgical Research Communications, 9(4), 279 - 288.
    • Wright D, Cooper A, Loizidou M, Smallwood J, Carpenter R, Taylor I (1990). Monocyte - derived giant cell formation in patients with breast cancer. European Journal of Surgical Oncology, 17, 245 - 250.
    • Lawrance R, Cooper A, Loizidou M, Alexander P, Taylor I (1990). Blood transfusion and recurrence of colorectal cancer: the role of platelet derived growth factors. British Journal of Surgery, 77, 1106 - 1109.

    1989

    • Carty N, Loizidou M, Taylor I (1989). The effect of syngeneic blood transfusion of chemically induced colon cancer in the rat,. Surgical Research Communications, 7, 79 - 83.

    • Goodyear G, Seebaluck J, Bartnik A, Loizidou MC, Welch H (). Gene silencing reveals a role for oestrogen finger protein (EFP) in tamoxifen resistance.
    • Adigbli A, Seebaluk J, MacRobert A, Loizidou M (). Bioluminescence mediated photodynamic therapy in breast cancer cell line.
    • Haque S, Winslet M, Loizidou M, Taylor I (). Endothelin receptors as an emerging target in colorectal cancers. Therapeutic Strategies-Oncology, , 86 - 91.
    • Loizidou M (). Towards the small and the beautiful: smart targeting and smart technologies for novel cancer treatments. Current Opinions in Pharmacology, 12(4), 389 - 391. doi:10.1016/j.coph.2012.06.007