Dr Lesley Rees

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Personal Profile

Name: Lesley Rees Email: l.rees@ucl.ac.uk
Title: Dr Tel: 02074059200
Department: ICH - Nephro-Urology Unit Fax: 2078298841
Position: Reader in Paediatric Nephrology Address: Renal office, Gt Ormond St Hospital for Children NHS Trust, London, WC1N3JH
Research Domain: Web Page:  

Profile

Research Description

Improvements in medical technology have led to the ability to treat even the youngest children with chronic kidney disease (CKD) with dialysis and transplantation. However, many children suffer from handicaps due to poor growth and renal bone disease. In addition, young adults have a risk of death from cardiovascular disease (CVD) equivalent to an 85 year old. The main focus of my research has been to investigate these three most significant, and inter-related, complications. My key objectives are to reduce morbidity by improving understanding of the causes and to identify preventative measures or treatments. This work has been conducted using clinical, basic science and translational research.

1) Growth in CKD
Poor growth in association with CKD is common, and may be due to endocrinological, nutritional and biochemical abnormalities. I have systematically investigated the roles of each cause. I hypothesised that the hypothalamo-pituitary-growth hormone axis might be contributory. My investigations demonstrated abnormal nocturnal pulsatile secretion of growth hormone and its mediators in children with CKD and in those taking steroid therapy. This led me to hypothesise that growth hormone might be an effective treatment, so I conducted the first trial of growth hormone therapy in CKD and post transplant. I showed it to be efficacious and safe in the short term. However, at follow-up of these patients 10 years later, I was unable to demonstrate a long-term benefit. This directed me to study the impact of intensive nutrition. I led retrospective reviews of the growth of our patients and showed that nutrition is the most important factor in the prevention of growth failure in CKD; our unit is recognised worldwide for our feeding programmes.

2) Renal bone disease
Renal bone disease is a cause of poor growth and also pain and deformity.

Research Activities

Blood vessels and the kidney

Major complications of chronic kidney disease (CKD)

Education Description

MD student projects (principal supervisor, all students have passed)

1. 'Factors predisposing to arterial disease in children with chronic renal failure', 1999, University of London
2. 'Growth in renal disease', 2001, University of Edinburgh
3.'A study of the mechanisms of action of growth hormone therapy in renal disease', 2004, University of London
4.'A study of renal osteodystrophy', 2004, University of London
5.'A study of treatments for endothelial dysfunction in chronic renal failure', 2004, University of London


Current MD student:
'Mechanisms, clinical consequences and treatment of intradialytic hypotension' to submit this year

Principal supervisor for successful PhD 'Vascular calcification and its relationship to renal osteodystrophy', University of London, 2008

Since 1990, with consultant colleagues, I have organised the annual week's course on topics in paediatric nephrology at The Institute of Child Health. The course is intended to offer up-to-date information on developments in paediatric nephrology and urology to an international audience of Paediatric Nephrologists and Urologists.

In 1996 I established an annual study day on 'Paediatric Nephrology for General Paediatricians', at the ICH, attended by approximately 100 from the UK and abroad.

I have been part of scientific organising committees, reviewed abstracts and have chaired sessions for international nephrology meetings. I have been on the editorial board of two journals, and am currently on one. I have written 18 book chapters and I am senior author of a 'Handbook of Paediatric Nephrology' (Oxford University Press), which has been adopted as the protocol book in nephrology and has sold worldwide (>1500 copies).I have given 50 international invited lectures.

UCL Collaborators

Dr Paul Winyard; Dr David Long; Prof Irwin Nazareth

External Collaborators

Publications

    2012

    • Shroff R, Wan M, Gullett A, Ledermann S, Shute R, Knott C, Wells D, Aitkenhead H, Manickavasagar B, van't Hoff W, Rees L (2012). Ergocalciferol Supplementation in Children with CKD Delays the Onset of Secondary Hyperparathyroidism: A Randomized Trial. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 7(2), 216 - 223. doi:10.2215/CJN.04760511
    • Prytua A, Wells D, McLean T, Balona F, Gullett A, Knott C, Cantwell M, Hassen K, Ledermann S, Rees L, Shroff R (2012). Urinary and dialysate losses of vitamin D-binding protein in children on chronic peritoneal dialysis. PEDIATRIC NEPHROLOGY, 27(4), 643 - 649. doi:10.1007/s00467-011-2045-0

    2011

    • Lambert HJ, Stewart A, Gullett AM, Cordell HJ, Malcolm S, Feather SA, Goodship JA, Goodship THJ, Woolf AS, UK VUR Study Grp (2011). Primary, Nonsyndromic Vesicoureteric Reflux and Nephropathy in Sibling Pairs: A United Kingdom Cohort for a DNA Bank. CLIN J AM SOC NEPHRO, 6(4), 760 - 766. doi:10.2215/CJN.04580510
    • Shroff R, Knott C, Gullett A, Wells D, Marks SD, Rees L (2011). Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients.. Pediatr Nephrol, 26(12), 2227 - 2233. doi:10.1007/s00467-011-1920-z
    • Rees L, Mak RH (2011). Nutrition and growth in children with chronic kidney disease. NATURE REVIEWS NEPHROLOGY, 7(11), 615 - 623. doi:10.1038/nrneph.2011.137
    • Rees L, Azocar M, Borzych D, Watson AR, Buescher A, Edefonti A, Bilge I, Askenazi D, Leozappa G, Gonzales C, van Hoeck K, Secker D, Zurowska A, Ronnholm K, Bouts AHM, Stewart H, Ariceta G, Ranchin B, Warady BA, Schaefer F, Net IPPD (2011). Growth in Very Young Children Undergoing Chronic Peritoneal Dialysis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 22(12), 2303 - 2312. doi:10.1681/ASN.2010020192

    2010

    • Waters AM, Pappworth I, Marchbank K, Bockenhauer D, Tullus K, Pickering M, Strain L, Sebire N, Rees L (2010). Successful renal transplantation in Factor H Autoantibody Associated HUS with CFHR1 and 3 Deficiency and CFH Variant G2850T.. American journal of transplantation, , - .
    • Waters AM, Pappworth I, Marchbank K, Bockenhauer D, Tullus K, Pickering MC, Strain L, Sebire N, Shroff R, Marks SD, Goodship TH, Rees L (2010). Successful renal transplantation in factor H autoantibody associated HUS with CFHR1 and 3 deficiency and CFH variant G2850T.. Am J Transplant, 10(1), 168 - 172. doi:10.1111/j.1600-6143.2009.02870.x
    • Shroff RC, McNair R, Skepper JN, Figg N, Schurgers LJ, Deanfield J, Rees L, Shanahan CM (2010). Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification.. J Am Soc Nephrol, 21(1), 103 - 112. doi:10.1681/ASN.2009060640
    • Rees L, Shroff RC (2010). Phosphate binders in CKD: chalking out the differences.. Pediatr Nephrol, 25(3), 385 - 394. doi:10.1007/s00467-009-1329-0
    • Quinlan C, Cantwell M, Rees L (2010). Eosinophilic peritonitis in children on chronic peritoneal dialysis. PEDIATRIC NEPHROLOGY, 25(3), 517 - 522. doi:10.1007/s00467-009-1366-8
    • Rees L, Brandt ML (2010). Tube feeding in children with chronic kidney disease: technical and practical issues. doi:10.1007/s00467-009-1309-4
    • Cordell HJ, Darlay R, Charoen P, Stewart A, Gullett AM, Lambert HJ, Malcolm S, Feather SA, Goodship THJ, Woolf AS, Kenda RB, Goodship JA, UK VUR Study Grp (2010). Whole-Genome Linkage and Association Scan in Primary, Nonsyndromic Vesicoureteric Reflux. J AM SOC NEPHROL, 21(1), 113 - 123. doi:10.1681/ASN.2009060624
    • Borzych D, Rees L, Ha IS, Chua A, Valles PG, Lipka M, Zambrano P, Ahlenstiel T, Bakkaloglu SA, Spizzirri AP, Lopez L, Ozaltin F, Printza N, Hari P, Klaus G, Bak M, Vogel A, Ariceta G, Yap HK, Warady BA, Schaefer F, IPPN (2010). The bone and mineral disorder of children undergoing chronic peritoneal dialysis. KIDNEY INTERNATIONAL, 78(12), 1295 - 1304. doi:10.1038/ki.2010.316
    • Shroff R, Knott C, Rees L (2010). The virtues of vitamin D-but how much is too much?. PEDIATRIC NEPHROLOGY, 25(9), 1607 - 1620. doi:10.1007/s00467-010-1499-9

    2009

    • Rees L, Tizard EJ, Morgan AJ, Cubitt WD, Finerty S, Oyewole-Eletu TA, Owen K, Royed C, Stevens SJ, Shroff RC, Tanday MK, Wilson AD, Middeldorp JM, Amlot PL, Steven NM (2009). A Phase I Trial of Epstein-Barr Virus Gp350 Vaccine for Children With Chronic Kidney Disease awaiting Transplantation. Transplantation, 88, 1025 - 1029.
    • Krischock L, Gullett A, Bockenhauer D, Rees L, Trompeter RS, Marks SD (2009). Calcineurin-inhibitor free immunosuppression with mycophenolate mofetil and corticosteroids in paediatric renal transplantation improves renal allograft function without increasing acute rejection.. Pediatric Transplantation, 13, 475 - 481.
    • Borzych DB, Groothoff JWG, Arbeiter AA, van Hoeck KH, Pape LP, Klaus GK, Haffner DH, Mueller-Wiefel DMW, Rees LR, Lipka ML, Testa ST, Szczepanska MS, Drozdz DD, Watson AW, Vondrak KV, Printza NP, Zurowska AZ, Leozappa GL, Fischbach MF, Cochat PC, Ulinski TU, Ariceta GA, Warady AW, Schaefer FS (2009). Growth and nutritional status of children on Chronic PD; findings of the IPPN.
    • Rees L (2009). Haemodialysis. In Avner ED, Harmon WE, Niaudet P, Yoshikawa N (Ed.), Pediatric Nephrology (pp. 1818 - 1835). : Springer –Verlag.
    • Bockenhauer D, Adalat S, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van't Hoff W, Marks SD, Trompeter RS, Winyard PJ, Cansick J, Bingham C, Edghill EL, Shroff RC, Stanescu H, Ryffel G, Ellard S, Woolf AS (2009). hepatocyte nuclear factor 1 beta mutations are associated with hypomagnesaemia and renal magnesium wasting.
    • Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, van 'tHoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Cansick J, Mushtaq I, Dhillon HK, Bingham C, Edghill EL, Shroff R, Stanescu H, Ryffel GU, Ellard S, Bockenhauer D (2009). HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. Journal of the American Society of Nephrology, 20(5), 1123 - 1131.
    • Rossetti S, Kubly VJ, Consugar MB, Hopp K, Roy S, Horsley SW, Chauveau D, Rees L, Barratt TM, Van't Hoff WG, Niaudet WP, Torres VE, Harris PC (2009). Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease. Kidney International, 75(8), 848 - 855.
    • Mekahli D, Ledermann S, Rees L (2009). Long term follow up of infants with severe chronic kidney disease: 20 years follow-up. Pediatric Nephrology, 24(4), 917 - 917.
    • Mekahli D, Ledermann S, Rees L (2009). Long term follow up of infants with severe CKD;20 years follow up.
    • Rees L, Guignard J-P (2009). Renal disease. In (Ed.), Recent Advances in General Paediatrics (pp. 131 - 148). : John Libbey.
    • Quinlan C, Cantwell M, Rees L (2009). Eosinophilic peritonitis in children on chronic peritoneal. Pediatr Nephrol, , - .
    • Rees L, Brandt ML (2009). Tube feeding in children with chronic kidney disease:. Pediatr Nephrol, , - .
    • Mekahli D, Shaw V, Ledermann SE, Rees L (2009). Long-Term Outcome of Infants with Severe Chronic Kidney. Clin J Am Soc Nephrol, , - .
    • Rees L, Shroff RC (2009). Phosphate binders in CKD: chalking out the differences. Pediatr Nephrol, , - .
    • Rees L, Tizard EJ, Morgan AJ, Cubitt WD, Finerty S, Oyewole-Eletu TA, Owen K, Royed C, Stevens SJ, Shroff RC, Tanday MK, Wilson AD, Middeldorp JM, Amlot PL, Steven NM (2009). A phase I trial of epstein-barr virus gp350 vaccine for children with chronic kidney disease awaiting transplantation.. Transplantation, 88(8), 1025 - 1029. doi:10.1097/TP.0b013e3181b9d918
    • Hothi DK, Rees L, McIntyre C, Marek J (2009). IMPAIRED REGIONAL LEFT VENTRICULAR FUNCTION IN PAEDIATRIC HAEMODIALYSIS PATIENTS. PEDIATR NEPHROL, 24(9), 1816 - 1816.
    • Krischock L, Gullett A, Bockenhauer D, Rees L, Trompeter RS, Marks SD (2009). Calcineurin-inhibitor free immunosuppression with mycophenolate mofetil and corticosteroids in paediatric renal transplantation improves renal allograft function without increasing acute rejection.. Pediatr Transplant, 13(4), 475 - 481. doi:10.1111/j.1399-3046.2008.01031.x
    • Hothi DK, Rees L M, J B, J M, C W (2009). Pediatric myocardial stunning underscores the cardiac toxicity of conventional hemodialysis treatments. Clinical Journal of the American Society of nephrology, 4(4), 790 - 797.
    • Hothi DK, Rees L, Marek J, Burton J, McIntyre CW (2009). Pediatric myocardial stunning underscores the cardiac toxicity of conventional hemodialysis treatments.. Clin J Am Soc Nephrol, 4(4), 790 - 797. doi:10.2215/CJN.05921108
    • Rees L (2009). Long-term outcome after renal transplantation in childhood. Pediatric Nephrology, 24(3), 475 - 484.
    • Cansick J, Rees L, Koffman G, Van't Hoff W, Bockenhauer D (2009). A fatal case of cerebral oedema with hyponatraemia and massive polyuria after renal transplantation.. Pediatric Nephrology, 24, 1231 - 1234.

    2008

    • Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, Hiorns M, Donald AE, Deanfield J, Rees L, Shanahan CM (2008). Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation, 118(17), 1748 - 1757.
    • Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, Hiorns M, Donald AE, Deanfield J, Rees L, Shanahan CM (2008). Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis.. Circulation, 118(17), 1748 - 1757. doi:10.1161/CIRCULATIONAHA.108.783738
    • Shroff R, Egerton M, Bridel M, Shah V, Donald AE, Cole TJ, Hiorns MP, Deanfield JE, Rees L (2008). A bimodal association of vitamin D levels and vascular disease in children on dialysis. Journal of the American Society of Nephrology, 19(6), 1239 - 1246.
    • Shroff RC, Shah V, Hiorns MP, Schoppet M, Hofbauer LC, Hawa G, Schurgers LJ, Singhal A, Merryweather I, Brogan P, Shanahan C, Deanfield J, Rees L (2008). The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis. Nephrology Dialysis Transplantation, 23, 3263 - 3271.
    • Krishnan RG, Rees L, Tullus K, Bockenhauer D, Trompeter RS, Van't Hoff W, Sebire NJ, Marks SD (2008). A 30-year single centre experience of Membranoproliferative Glomerulonephritis.
    • Rees L (2008). What parathyroid hormone levels should we aim for in children with stage 5 chronic kidney disease; what is the evidence?. Pediatric Nephrology, 23(2), 179 - 184.
    • Waller S, Shroff R, Freemont AJ, Rees L (2008). Bone histomorphometry in children prior to commencing renal replacement therapy.. Pediatric Nephrology, 23, 1523 - 1529.
    • Rees L (2008). Management issues in children with renal disease. In Hodson E, Eddy A (Ed.), BMJ evidence based publications (pp. - ). : BMJ.
    • Rees L (2008). Management of the neonate with chronic renal failure.. Seminars in fetal and neonatal medicine, 13, 181 - 188.
    • Rees L (2008). Nutritional management in children with renal disese.. In Koletzko B (Ed.), Paediatric nutrition in practice. (pp. 234 - 238). : S Karger.
    • Bockenhauer D, Rees L, Neumann H, Foo Y (2008). A sporadic case of paraganglioma undetected by urine metabolite screening.. Pediatric Nephrology, 23, 1889 - 1891.

    2007

    • Abeyagunawardena AS, Sebire NJ, Risdon RA, Dillon MJ, Rees L, van 't Hoff W, Kumarasiri PV, Trompeter RS (2007). Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis. Pediatric Nephrology, 22(2), 215 - 221.
    • Rees L (2007). The kidney and urinary tract. In Lissauer T, Clayden G (Ed.), Illustrated Guide to Paediatrics (pp. - ). : Mosby Wolfe.
    • Shroff RC, Donald AE, Hiorns MP, Watson A, Feather S, Milford D, Ellins EA, Storry C, Ridout D, Deanfield J, Rees L (2007). Mineral metabolism and vascular damage in children on dialysis. Journal of the American Society of Nephrology, 18(11), 2996 - 3003.
    • Shroff RC, Donald AE, Hiorns MP, Watson A, Feather S, Milford D, Ellins EA, Storry C, Ridout D, Deanfield J, Rees L (2007). Mineral metabolism and vascular damage in children on dialysis.. J Am Soc Nephrol, 18(11), 2996 - 3003. doi:10.1681/ASN.2006121397
    • Shroff R, McNair R, Figg N, Donald A, Deanfield J, Rees L, Shanahan C (2007). Accelerated vascular calcification in dialysis patients is a vesicle-mediated process associated with apoptosis and osteoblastic differentiation in a model of intact human arteries.
    • Shroff R, Shah V, Schoppet M, Hofbauer L, Hawa G, Schurgers L, Donald A, Shanahan C, Deanfield J, Rees L (2007). Fetuin-A and osteoprotegerin are associated with vascular stiffness and calcification in children on dialysis.
    • Shroff R, Egerton M, Bridel M, Shah V, Donald A, Hiorns M, Deanfield J, Rees L (2007). Vitamin D has a bimodal effect on vascular structure and calcification in children on dialysis: Calcium-phosphate homeostasis and beyond.
    • Krischock L, Gullett A, Bockenhauer D, Rees L, Trompeter R, Marks S (2007). Calcineurin-inhibitor free immunosuppression with mycophenolate mofetil and steroids in pediatric renal transplantation improves renal allograft function without increasing acute rejection.
    • Cansick J, Waller S, Ridout D, Rees L (2007). Growth and PTH in prepubertal children on long-term dialysis.. Pediatr Nephrol, 22(9), 1349 - 1354. doi:10.1007/s00467-006-0348-3
    • Shroff R, McNair R, Figg N, Hiorns M, Donald A, Deanfield J, Rees L, Shanahan C (2007). Medial calcification in intact human arteries from children with chronic kidney disease is associated with apoptosis and osteogenic differentiation - clinical and laboratory correlations.
    • Shroff R, Egerton M, Bridel M, Shah V, Hiorns M, Donald A, Ellins E, Deanfield J, Rees L (2007). Vitamin D, inflammation and vascular calcification in children on dialysis.
    • Rees L (2007). Long-term peritoneal dialysis in infants. Peritoneal Dialysis International, 27 Suppl 2, S180 - S184.
    • Shroff R, McNair R, Figgs N, Donald A, Deanfield J, Rees L, Shanahan C (2007). An in vitro model of intact human arteries to study the pathophysiology of medial calcification in renal failure.
    • Waller S, Ridout D, Rees L (2007). Effect of haemodialysis on markers of bone turnover in children.. Pediatr Nephrol, 22(4), 586 - 592. doi:10.1007/s00467-006-0378-x
    • Waller S, Ridout D, Rees L (2007). Effect of haemodialysis on markers of bone turnover in children. Pediatric.Nephrology., 22, 586 - 592.
    • Waller S, Ridout D, Rees L (2007). Bone mineral density in children with chronic renal failure. Pediatric Nephrology, 22(1), 121 - 127.
    • Waller S, Ridout D, Rees L (2007). Bone mineral density in children with chronic renal failure.. Pediatr Nephrol, 22(1), 121 - 127. doi:10.1007/s00467-006-0292-2
    • Guignard J-P, Rees L (2007). Developpements recents en nephrologie pediatrique. In (Ed.), Paediatrica (pp. 61 - 62). : .
    • Rees L, Shroff R, Hutchinson C, Fernando ON, Trompeter RS (2007). Long-term outcome of paediatric renal transplantation: follow-up of 300 children from 1973 to 2000. Nephron Clinical Practice, 105(2), c68 - c76.
    • Rees L, Shaw V (2007). Nutrition in children with CRF and on dialysis.. Pediatric Nephrology, 22, 1689 - 1702.
    • Rees L, Webb NJA, Brogan PA (2007). Oxford Specialist Handbook of Paediatric Nephrology.
    • Marks SD, Rees L, Brogan P, Sebire NJ, Van't Hoff W (2007). Paediatric Renal Pathology. In Strobel S, Marks SD, Smith P, El Habbal MH, Spitz L (Ed.), The Great Ormond Street Colour Handbook (pp. - ). : Manson Publishing.
    • Barratt TM, Ledermann SE, Roy S, Rees L, Goonaskera CG, Dillon MJ, Nash M, van't Hoff W, Feather SA, Winyard PJD, de Bruyn R, Marks SD (2007). Renal Diseases. In Strobel S, Spitz L, Marks S, El Habbal M (Ed.), The Great Ormond Street Colour Handbook of Paediatrics and Child Health (pp. 297 - 311). : Manson Publishing.
    • Cansick J, Waller S, Ridout D, Rees L (2007). Growth and PTH in prepubertal children on long-term dialysis. Pediatric Nephrology, 22, 1349 - 1354.

    2006

    • Shroff R, McNair R, Figg N, Donald A, Deanfield J, Rees L, Shanahan C (2006). "An in-vitro model of intact human arteries to study the pathophysiology of medial calcification in renal failure".
    • Loukogeorgakis SP, Rees L, Dalton NR, MacAllister RJ, Deanfield JE (2006). "Remote ischemic preconditioning protects against ischemia reperfusion injury in pediatric renal transplantation".
    • Abeyagunawardena AS, Pallegoda A, Kumarasiri V, Risdon RA, Dillon MJ, Rees L, Van't Hoff W, Trompeter RS, Sebire NJ (2006). Histopathological predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis.
    • Taghizadeh A, Desai D, Ledermann S, Shroff R, Rees L, Marks S, Koffman G, Duffy P, Cuckow P (2006). "Renal transplantation or bladder augmentation first? A comparison of complications and outcomes".
    • Bockenhauer D, Rees L, van't HW (2006). An association of tubular dysfunction, cortical macrocysts and chronic kidney disease. Pediatric Nephrology, 21(4), 580 - 583.
    • Winyard PJ, Bharucha T, De BR, Dillon MJ, van't HW, Trompeter RS, Liesner R, Wade A, Rees L (2006). Perinatal renal venous thrombosis: presenting renal length predicts outcome. Archives of Disease in Childhood - Fetal and Neonatal Edition, 91(4), F273 - F278.

    2005

    • Shroff R, Rees L, Trompeter R, Hutchinson C, Ledermann S (2005). Long-term outcome of chronic dialysis in children. Pediatric Nephrology, , - .
    • Sebire NJ, Malone M, Risdon RA, Trompeter R, van't Hoff W, Rees L (2005). Paediatric percutaneous renal biopsy pathology: A review of 1,271 cases from a single centre.
    • Waller SC, Ridout D, Cantor T, Rees L (2005). Parathyroid hormone and growth in children with chronic renal failure. Kidney International, 67(6), 2338 - 2345. doi:10.1111/j.1523-1755.2005.00339.x
    • Waller SC, Ridout D, Cantor T, Rees L (2005). Parathyroid hormone and growth in children with chronic renal failure.. Kidney Int, 67(6), 2338 - 2345. doi:10.1111/j.1523-1755.2005.00339.x
    • Mallya M, Rees L (2005). PAX2 mutation and tumorigenesis. Journal of Medical Genetics, 42, S115 - S115.
    • Waller S, Ridout D, Cantor T, Rees L (2005). Differences between "intact" PTH and 1-84 PTH assays in chronic renal failure and dialysis.. Pediatr Nephrol, 20(2), 197 - 199. doi:10.1007/s00467-004-1735-2
    • Carasi C, van't Hoff WG, Rees L, Risdon RA, Trompeter RS, Dillon MJ (2005). Childhood thin GBM disease: review of 22 children with family studies and long-term follow-up. Pediatric Nephrology, 20(8), 1098 - 1105.
    • Kari JA, Rees L (2005). Growth hormone for children with chronic renal failure and on dialysis. Pediatric Nephrology, 20(5), 618 - 621.
    • Waller S, Ridout D, Cantor T, Rees L (2005). Differences between "intact" PTH and 1-84 PTH assays in chronic renal failure and dialysis. Pediatric Nephrology, 20(2), 197 - 199. doi:10.1007/s00467-004-1735-2

    2004

    • Shroff R, Hutchinson C, Trompeter R, Rees L, Ledermann S (2004). "Long-term outcome of peritoneal and haemodialysis in paediatric patients".
    • Ledermann SE, Rees L (2004). Long-term outcome of peritoneal dialysis and haemodialysis in pediatric patients. In Warady BA, Schaefer F, Fine RN, Alexander SR (Ed.), Pediatric Dialysis (pp. 485 - 499). : Kluwer Academic Publishers.
    • Shroff R, Rees L (2004). The post-transplant lymphoproliferative disorder-a literature review. Pediatric Nephrology, 19(4), 369 - 377.
    • Nagra A, Trompeter RS, Fernando ON, Koffman G, Taylor JD, Lord R, Hutchinson C, O'Sullivan C, Rees L (2004). The effect of heparin on graft thrombosis in pediatric renal allografts.. Pediatric Nephrology, 19(5), 531 - 535.

    2003

    • Waller S, Ledermann S, Trompeter R, van't Hoff W, Ridout D, Rees L (2003). Catch-up growth with normal parathyroid hormone levels in chronic renal failure. Pediatric Nephrology, 18(12), 1236 - 1241.
    • Waller S, Ledermann S, Trompeter R, van't Hoff W, Ridout D, Rees L (2003). Catch-up growth with normal parathyroid hormone levels in chronic renal failure.. Pediatr Nephrol, 18(12), 1236 - 1241. doi:10.1007/s00467-003-1284-0
    • Waller S, Reynolds A, Ridout D, Cantor T, Gao P, Rees L (2003). Parathyroid hormone and its fragments in children with chronic renal failure. Pediatric Nephrology, 18(12), 1242 - 1248.
    • Hutchinson C, Beckett M, Kiratli P, Gordon I, Trompeter RS, Rees L (2003). The significance of a defect on DMSA scan in children with renal transplants. Pediatric Transplantation, 7, 441 - 445.
    • Abeyagunawardena AS, Dillon MJ, Rees L, van't Hoff W, Trompeter RS (2003). The use of steroid-sparing agents in steroid-sensitive nephrotic syndrome. Pediatric Nephrology, 18(9), 919 - 924.
    • Pahari A, Rees L (2003). BK virus-associated renal problems--clinical implications. Pediatric Nephrology, 18(8), 743 - 748.
    • Shroff R, Wright E, Ledermann S, Hutchinson C, Rees L (2003). Chronic hemodialysis in infants and children under 2 years of age. Pediatric Nephrology, 18(4), 378 - 383.
    • Waller S, Reynolds A, Ridout D, Cantor T, Gao P, Rees L (2003). Parathyroid hormone and its fragments in children with chronic renal failure.. Pediatr Nephrol, 18(12), 1242 - 1248. doi:10.1007/s00467-003-1267-1

    2002

    • Bennett-Richards KJ, Kattenhorn M, Donald AE, Oakley GR, Varghese Z, Bruckdorfer KR, Deanfield JE, Rees L (2002). Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney International, 62(4), 1372 - 1378. doi:10.1111/j.1523-1755.2002.kid555.x
    • Bennett-Richards KJ, Kattenhorn M, Donald AE, Oakley GR, Varghese Z, Bruckdorfer KR, Deanfield JE, Rees L (2002). Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. KIDNEY INTERNATIONAL, 62(4), 1372 - 1378. doi:10.1046/j.1523-1755.2002.00555.x
    • Fairbanks LD, Cameron JS, Venkat-Raman G, Rigden SP, Rees L, Van'T HW, Mansell M, Pattison J, Goldsmith DJ, Simmonds HA (2002). Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long-term progression of renal disease. QJM, 95(9), 597 - 607.
    • Shroff R, Trompeter R, Cubitt D, Thaker U, Rees L (2002). Epstein-Barr virus monitoring in paediatric renal transplant recipients. PEDIATRIC NEPHROLOGY, 17(9), 770 - 775. doi:10.1007/s00467-002-0931-1
    • Rees L (2002). Management of the infant with end-stage renal failure. NEPHROLOGY DIALYSIS TRANSPLANTATION, 17(9), 1564 - 1567. doi:10.1093/ndt/17.9.1564
    • Pinkerton CR, Hann I, Weston CL, Mapp T, Wotherspoon A, Hobson R, Kelly DA, Vergani D, Hadzic D, Rees L, Burke M, Alero TJ (2002). Immunodeficiency-related lymphoproliferative disorders: prospective data from the United Kingdom Children's Cancer Study Group Registry. British Journal of Haematology, 118(2), 456 - 461.
    • Waller SC, Rees L, Woolf AS, Ellard S, Pearson ER, Hattersley AT, Bingham C (2002). Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the Hepatocyte Nuclear Factor-1beta gene. American Journal of Kidney Diseases, 40(6), 1325 - 1330.
    • Shroff R, Trompeter R, Cubitt D, Thaker U, Rees L (2002). Epstein-Barr virus monitoring in paediatric renal transplant recipients. Pediatric Nephrology, 19(9), 770 - 775.
    • Ledermann SE, Spitz L, Moloney J, Rees L, Trompeter RS (2002). Gastrostomy feeding in infants and children on peritoneal dialysis. Pediatric Nephrology, 17(4), 246 - 250.
    • Rees L, Kovacs G (2002). Growth and Puberty. In Cochat P (Ed.), European Society of Paediatric Nephrology Handbook (pp. 382 - 384). : Novartis.
    • Rees L (2002). Management of the infant with end-stage renal failure: editorial, child-adult interface. Nephrology Dialysis Transplantation, 17, 1564 - 1576.
    • Rees L (2002). Paediatric supplement. In Royal COP (Ed.), Treatment of adults and children with renal failure (pp. - ). : .
    • Bennett-Richards K, Kattenhorn M, Donald A, Oakley G, Varghese Z, Rees L, Deanfield JE (2002). Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure?. Circulation, 105(15), 1810 - 1815. doi:10.1161/01.CIR.0000014417.95833.1D

    2001

    • Kapila P, Jones J, Rees L (2001). Effect of chronic renal failure and prednisolone on the growth hormone-insulin-like growth factor axis. PEDIATRIC NEPHROLOGY, 16(12), 1099 - 1104.
    • Rees L (2001). The kidney and Urinary tract. In (Ed.), Illustrated guide to paediatrics (pp. 253 - 269). : Mosbey wolfe.
    • Kapila P, Jones J, Rees L (2001). Effect of CRF and prednisolone on the GH-IGF axis.. Pediatric Nephrology, 16, 1099 - 1105.

    2000

    • Maxwell H, Amlot P, Rees L (2000). Growth hormone and markers of immune function in children with renal transplants. Pediatric Nephrology, 14(6), 473 - 475.
    • Koziell A, Charmandari E, Hindmarsh PC, Rees L, Scambler P, Brook CG (2000). Frasier syndrome, part of the Denys Drash continuum or simply a WT1 gene associated disorder of intersex and nephropathy?. Clinical Endocrinology, 52(4), 519 - 524.
    • Marks SD, Rees L (2000). Spontaneous clinical improvement in dense deposit disease. Pediatric Nephrology, 14(4), 322 - 324.
    • Kari JA, Gonzalez C, Ledermann SE, Shaw V, Rees L (2000). Outcome and growth of infants with severe chronic renal failure. Kidney International, 57(4), 1681 - 1687.
    • Saleem MA, Ramanan AV, Rees L (2000). Recurrent focal segmental glomerulosclerosis in grafts treated with plasma exchange and increased immunosuppression. Pediatric Nephrology, 14(5), 361 - 364.
    • Rees L, Ward G, Rigden SPA (2000). Growth over 10 years following a 1-year trial of growth hormone therapy. Pediatric Nephrology, 14(4), 309 - 314.

    1999

    • Winyard PJD, Liesner R, Trompeter RS, Rees LR (1999). Neonatal renal venous thrombosis - predisposing factors, management and outcome.
    • Kari JA, Romagnoli J, Duffy PG, Fernando ON, Rees L, Trompeter RS (1999). Renal transplantation in children under 5 years of age. Pediatric Nephrology, 13, 730 - 737.

    1998

    • Sharifian M, Rees L, Trompeter RS, Rees L (1998). High incidence of bacteriuria following renal transplantation in children.. Nephrology Dialysis Transplantation, 13, 432 - 435.
    • McBride MB, Rigden S, Haycock GB, Dalton N, Van't Hoff W, Rees L, Raman GV, Moro F, Ogg CS, Cameron JS, Simmonds HA (1998). Presymptomatic detection of familial juvenile hyperuricaemic nephropathy in children. Pediatric Nephrology, 12, 357 - 364.
    • Maxwell H, Rees L (1998). Randomised controlled trial of recombinant human growth hormone in prepubertal and pubertal renal transplant recipients. British Association for Pediatric Nephrology.. Archives of Disease in Childhood, 79, 481 - 287.
    • Rees L, Thomas JA, Amlot PL (1998). Disappearance of an EBV+ post-transplant plasmacytoma with controlled reduction of immunosuppresion. The Lancet, 352(9130), 789 - 789.
    • Kari J, Shaw V, Vallance D, T R, L (1998). Effect of enteral feeding on lipid subfractions in children with chronic renal failure.. Pediatric Nephrology, 12, 401 - 404.
    • Maxwell H, Rees L, Nephrology BAP (1998). Randomised controlled trial of recombinant human growth hormone in prepubertal and pubertal renal transplant recipients. ARCHIVES OF DISEASE IN CHILDHOOD, 79(6), 481 - 487.
    • Rees L, Thomas A, Amiot PL (1998). Disappearance of an Epstein-Barr virus-positive post-transplant plasmacytoma with reduction of immunosuppression. LANCET, 352(9130), 789 - 789. doi:10.1016/S0140-6736(05)60684-8
    • Maxwell H, Haffner D, Rees L (1998). Catch-up growth occurs after renal transplantation in children of pubertal age.. Journal of Pediatrics, 133, 435 - 440.
    • McBride MB, Simmonds HA, Ogg CS, Cameron JS, Rigden S, Rees L, Van 't Hoff W, Moro F, Raman GV (1998). Efficacy of allopurinol in ameliorating the progressive renal disease in familial juvenile hyperuricaemic nephropathy (FJHN). A six-year update.. Advances in Experimental and Medical Biology, 431, 7 - 11.
    • van 'tHoff WG, Dixon M, Taylor J, Mistry P, Rolles K, Rees L, Leonard JV (1998). Combined liver-kidney transplantation in methylmalonic acidemia. Journal of Pediatrics, 132, 1043 - 1044.

    1997

    • Rees L (1997). (on behalf of the British Association for Peadiatric Nephrology).Compliance with growth hormone therapy in chronic renal failure and post transplant. Pediatric Nephrology, 11(6), 752 - 754.
    • Rees L, Nephrology BAP (1997). Compliance with growth hormone therapy in chronic renal failure and post transplant. PEDIATRIC NEPHROLOGY, 11(6), 752 - 754.
    • Rees L (1997). Human Growth Hormone in Renal Disease. British Journal of Renal Medicine, 2, 9 - 13.
    • Kari JA, Donald AE, Vallance DT, Bruckdorfer KR, Leone A, Mullen MJ, Bunce T, Dorado B, Deanfield JE, Rees L (1997). Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney International, 52, 468 - 472.
    • Cope AV, Sweny P, Sabin CA, Rees L, Griffiths PD, Emery VC (1997). Quantity of Cytomegalovirus viruia Is a major risk factor for Cytomegalovirus disease after renal transplantation. Journal of Medical Virology, 52(2), 200 - 205.
    • Demircin G, Rees L (1997). Retransplantation after post-transplant lymphoproliferative disease. Pediatric Nephrology, 11(3), 358 - 360.

    1996

    • Rees L (1996). Causes of failure to respond to recombinant human growth hormone (rhGH).. British Journal of Clinical Practice Symposium Supplement, 85, 32 - 33.
    • Peral B, Ong AC, San Millán JL, Gamble V, Rees L, Harris PC (1996). A stable, nonsense mutation associated with a case of infantile onset polycystic kidney disease 1 (PKD1).. Human and Molecular Genetics, 5, 539 - 542.
    • Maxwell H, Dalton RN, Nair DR, Turner C, Saunders AJ, Rigden SP, Rees L (1996). Effects of recombinant human growth hormone on renal function in children with renal transplants. Journal of Pediatrics, 128, 177 - 183.
    • Rees L, Maxwell H (1996). Factors influencing the response to growth hormone in children with renal disease. Pediatric Nephrology, 10, 337 - 339.
    • Rees L (1996). The role of recombinant human growth hormone (rhGH) in pubertal patients. British Journal of Clinical Practice Symposium Supplement, 85, 14 - 17.
    • Blake KD, Madden S, Taylor BW, Rees L (1996). Psychological and clinical effects of renal biopsy performed using sedation.. Pediatric Nephrology, 10, 693 - 695.
    • Maxwell H, Rees L (1996). Recombinant human growth hormone treatment in infants with chronic renal failure.. Archives of Disease in Childhood, 74, 40 - 43.
    • Rees L, Maxwell H (1996). The hypothalamo-pituitary-growth hormone insulin-like growth factor 1 axis in children with chronic renal failure.. Kidney International, 53, S109 - S114.
    • Rees L (1996). The kidney and urinary tract. In Lissauer T, Clayden G (Ed.), Illustrated guide to paediatrics (pp. 193 - 208). : Mosby-Wolfe.
    • Nijsten EW, Rees L (1996). Plasma exchange in steroid and anti-thymocyte globulin resistant allograft rejection in children. Pediatric Nephrology, 10, 613 - 615.

    1995

    • Rees L (1995). Growth in renal disease. In (Ed.), Cambridge encyclopaedia of human growth and development (pp. 284 - 285). : Cambridge University Press.
    • Maxwell H, Nair DR, Dalton RN, Rigden SP, Rees L (1995). Differential effects of recombinant human growth hormone on glomerular filtration rate and renal plasma flow in chronic renal failure.. Pediatric Nephrology, 9, 458 - 463.
    • Rees L (1995). Stop the growth hormone!. Medicom, , - .

    1994

    • SCHAEFER F, VELDHUIS J, ROBERTSON W, DUNGER D, SCHARER K, BARRATT T, HAMILL G, LEDERMAN S, TROMPETER R, PERFUMO F, REES L, FINE R, RIGDEN S, GEARY D, POSTLETHWAITHE R, MICHALK D (1994). IMMUNOREACTIVE AND BIOACTIVE LUTEINIZING-HORMONE IN PUBERTAL PATIENTS WITH CHRONIC-RENAL-FAILURE. KIDNEY INTERNATIONAL, 45(5), 1465 - 1476. doi:10.1038/ki.1994.191
    • Schaefer F, Veldhuis JD, Stanhope R, Jones J S, K O, G B, T M H, G L, S T, R S P, F R, L F, R N R, S G, D P, R M, D D, S (1994). Alterations in growth-hormone secretion and clearance in peripubertal boys with chronic-renal-failure and after renal-transplantation.. Journal of Clinical Endocrinology and Metabolism, 78, 1298 - 1306.
    • Rees L (1994). Growth post transplantation in children: steroids and growth inhibition.. In (Ed.), Pediatric renal transplantation (pp. 423 - 441). : Wiley Liss.
    • Rees L (1994). Paediatric Addenda. In (Ed.), Standards and audit in renal disease (pp. - ). : Royal College of Physicians.
    • Rees L (1994). The use of recombinant human erythropoietin in children with renal disese. Journal of Pharmaceutical Medicine, 4, 65 - 78.

    1993

    • Iragorri S, Pillay D, Scrine M, Trompeter RS, Rees L, Griffiths PD (1993). Prospective cytomegalovirus surveillance in paediatric renal transplant patients.. Pediatr Nephrol, 7(1), 55 - 60.
    • Iragorri S, Pillay D, Scrine M, Trompeter RS, Rees L, Griffiths PD (1993). Prospective cytomegalovirus surveillance in paediatric renal transplant patients.. Pediatric Nephrology, 7, 55 - 60.
    • Rees L, Black D (1993). Renal disease in Adolescence. In (Ed.), The Practice of Medicine in adolescence (pp. 147 - 161). : Edward Arnold.

    1992

    • Rees L (1992). Endocrine abnormalities in chronic renal failure that may affect growth.. Growth and growth factors, 7, 91 - 94.
    • Rees L (1992). Growth in renal disease. Growth Matters, 9, 5 - 6.
    • Houlston RS, Iraggori S, Murday V, Scrine M, Macdermot K, Slack J, Rees L (1992). Microcephaly, focal segmental glomerulonephritis and marfanoid habitus in two sibs.. Clinical Dysmorphology, 1, 111 - 113.

    1991

    • Pillay D, Patou G, Griffiths PD, Rees , L (1991). Secondary parvovirus B19 infection in an immunocompromised child.. Pediatric Infectious Diseases Journal, 10, 623 - 624.
    • Rees L, Rigden SP, Chantler C (1991). The influence of steroid therapy and recombinant human erythropoietin on the growth of children with renal disease.. Pediatric Nephrology, 5, 556 - 558.

    1990

    • Rees L, Rigden SPA, Chantler C (1990). Growth and endocrine function in children receiving long term steroid therapy. Acta Paediatrica Scandinavica, 336, 93 - 96.
    • Rees L, Rigden SPA, Chantler C (1990). Growth and Endocrine function in children with chronic renal failure. Acta Paediatrica Ccandinavica, S370, 20 - 27.
    • Rees L, Rigden SP, Ward G, Preece MA (1990). Treatment of short stature in renal disease with recombinant human growth hormone.. Archives of Disease in Childhood, 65, 856 - 660.
    • Rees L, Greene SA, Rigden SP, Haycock GB, Chantler C, Preece MA (1990). Oxandrolone for delayed puberty in boys taking long-term steroid therapy for renal disease.. Pediatric Nephrology, 4, 160 - 162.

    1989

    • Rees L, Rigden SP, Ward GM (1989). Chronic renal failure and growth.. Archives of Disease in Childhood, 64, 573 - 577.
    • Rees L, Rigden SPA, Haycock GB, Chantler C (1989). Growth and methods of improving growth in chronic renal failure managed conservatively. In (Ed.), Paediatric and Adolescent Endocrinology (pp. 15 - 26). : Karger.

    1988

    • Rees L, Greene SA, Adlard P, Jones J, Haycock GB, Rigden SP, Preece M, Chantler C (1988). Growth and endocrine function in steroid sensitive nephrotic syndrome.. Arch Dis Child, 63(5), 484 - 490.
    • Rees L, van SV (1988). Mothers and doctors. The Independent, , - .
    • Rees L, Greene SA, Adlard P, Jones J, Haycock GB, Rigden SP, Preece M, Chantler C (1988). Growth and endocrine function after renal transplantation.. Arch Dis Child, 63(11), 1326 - 1332.
    • Rees L, Greene SA, Adlard P, Jones J, Haycock GBR, S P P, M C, C (1988). Growth and endocrine function after renal transplantation.. Archives of Disease in Childhood, 63, 1326 - 1332.
    • Rees L, Greene SA, Adlard P, Jones J, Haycock GB, Rigden SP, Preece M, Chantler C (1988). Growth and endocrine function in steroid sensitive nephrotic syndrome.. Archives of Disease in Childhood, 63, 484 - 490.

    1987

    • Rees L, Chantler C (1987). Hormonal alterations that may affect the growth of children with chronic renal disease. In (Ed.), (pp. 989 - 1002). : Balliere Tindall.
    • Rigden SP, Start KM, Rees L (1987). Nutritional management of infants and toddlers with chronic renal failure.. Nutrition and Health, 5, 163 - 174.

    1986

    • Rees L, van SV (1986). Problems facing women who seek a career in paediatrics. Archives of Disease in Childhood, 61, 989 - .

    1985

    • Walker A, Rees L (1985). Mythical contraindications to vaccination.. The Lancet, 1(8435), 994 - 994.

    1984

    • Rees L, Forsling ML, Shaw JC, Brook CG (1984). Hyponatraemia in the first week of life in preterm infants. Part I. Arginine vasopressin secretion.. Archives of Disease in Childhood, 59, 414 - 422.
    • Rees LS, J C B, C G F, M L (1984). Hyponatraemia in the first week of life in preterm infants. Part II. Sodium and water balance.. Archives of Disease in Childhood, 59, 423 - 429.
    • van Someren V, Rees L (1984). Personal view. British Medical Journal (Clinical Research Ed.), 289, 827 - .

    1983

    • Rees LBCG, Forsling ML (1983). : Continuous urine collection in the study of vasopressin in the newborn.. Hormone Research, 17, 134 - 140.

    1982

    • Rees L (1982). Sodium and water balance in premature infants, with particular reference to the role of arginine vasopressin. MD University of Manchester.

    1980

    • Rees L, Vlies R A, J (1980). Hydrops fetalis, an unusual cause, presentation and method of diagnosis. Case report.. british Journal of Obstetrics and Gynaecology, 87, 1169 - 1170.
    • Rees L, Forsling M, Brook CGD (1980). Vasopressin concentrations in the neonatal period.. Clinical Endocrinology, 12, 357 - 362.

    1979

    • Rees L, Brook CDG (1979). Gradual reintroduction of full-strength milk after acute gastroenteritis in children.. The Lancet, 7, 770 - 771.
    • Gewitz M, Dinwiddie R, Rees L, Volikas O, Yuille T, O'Connell B, Marshall WC (1979). Mycoplasma hominis. A cause of neonatal meningitis.. Archives of Disease in Childhood, 54, 231 - 233.

    • Rees L, Tizard J, Morgan A, Cubitt D, Finerty S, Oyewole-Eletu T, Owen K, Royed C, Stevens S, Shroff R, Tanday M, Thaker U, Wilson D, Middeldorp J, Amlot P, Steven N (). A phase I trial of Epstein-Barr virus gp350 vaccine for children with end stage renal failure awaiting transplantation.. Transplantation, , - .
    • Shroff R, C M, R S, J N F, N LS, L D, J R, L S, C M (). Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. Journal of the American Society of Nephrology, , - .
    • Rees L, Shroff R (). Phosphate binders; chalking out the differences. Pediatric Nephrology, , - .
    • Mekhali D, Shaw V, Ledermann SE, Rees L (). Long term outcome of infants with severe CKD.. Clinical Journal of the American Society of Nephrology, , - .
    • Rees L, Brandt M (). Tube feeding in children with CKD; technical and practical issues.. Pediatric Nephrology, , - .