Dr Kiran Nistala

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Personal Profile

Name: Kiran Nistala Email: k.nistala@ucl.ac.uk
Title: Dr Tel:
Department: Inflammation Fax:
Position: Clinical Research Fellow / Honorary Clinical Consultant Address: Fourth floor, Rayne Institute, 5 University Street, London,
Research Domain: Infection, Immunology & Inflammation, Personalised Medicine Web Page:  

Profile

Research Description

I have studied T cell immunology in juvenile idiopathic arthritis during my PhD and demonstrated a link between a pro-inflammatory population of cells, called Th17, found in the inflamed joint and the severity of the child's arthritis. In 2012 I was awarded a Wellcome Trust Clinician Scientist Fellowship and have been investigating the transcriptional control of regulatory B cells together with Professor Mauri, UCL. 


Research Activities

Regulatory B cell biology

TH17 in Juvenile Idiopathic Arthritis

Education Description

UCL Collaborators

External Collaborators

Publications

    2014

    • Piper C, Pesenacker AM, Bending D, Thirugnanabalan B, Varsani H, Wedderburn LR, Nistala K (2014). T cell GM-CSF expression in juvenile arthritis is contingent upon Th17 plasticity.. Arthritis Rheumatol, , - . doi:10.1002/art.38647
    • Nistala K, Mauri C (2014). The quest for personalized B-cell depletion therapy in rheumatic disease. Arthritis Research and Therapy, 16(3), - . doi:10.1186/ar4595
    • Mauri C, Nistala K (2014). Interleukin-35 takes the 'B' line.. Nat Med, 20(6), 580 - 581. doi:10.1038/nm.3594

    2013

    • Pesenacker AM, Bending D, Ursu S, Wu Q, Nistala K, Wedderburn LR (2013). CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines.. Blood, 121(14), 2647 - 2658. doi:10.1182/blood-2012-08-443473
    • Nistala K, Wedderburn LR (2013). Update in juvenile myositis.. Curr Opin Rheumatol, 25(6), 742 - 746. doi:10.1097/01.bor.0000434674.62644.02
    • Nistala K, Varsani H, Wittkowski H, Vogl T, Krol P, Shah V, Mamchaoui K, Brogan PA, Roth J, Wedderburn LR (2013). Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis. Arthritis Res Ther, 15, R131 - . doi:10.1186/ar4311
    • Nistala K, Wedderburn LR (2013). Update in juvenile myositis. Current Opinion in Rheumatology, 25(6), 742 - 746. doi:10.1097/01.bor.0000434674.62644.02

    2012

    • Ruperto N, Brunner HI, Quartier P, Constantin T, Wulffraat N, Horneff G, Brik R, McCann L, Kasapcopur O, Rutkowska-Sak L, Schneider R, Berkun Y, Calvo I, Erguven M, Goffin L, Hofer M, Kallinich T, Oliveira SK, Uziel Y, Viola S, Nistala K, Wouters C, Cimaz R, Ferrandiz MA, Flato B, Gamir ML, Kone-Paut I, Grom A, Magnusson B, Ozen S, Sztajnbok F, Lheritier K, Abrams K, Kim D, Martini A, Lovell DJ, PRINTO , PRCSG (2012). Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis.. N Engl J Med, 367(25), 2396 - 2406. doi:10.1056/NEJMoa1205099
    • Pesenacker AM, Nistala K, Wedderburn LR (2012). Regulatory T cells expressing the killer cell lectin-like receptor cd161 have a greater potential for pro-inflammatory cytokine production and are enriched in childhood arthritis.
    • Omoyinmi E, Hamaoui R, Pesenacker A, Nistala K, Moncrieffe H, Ursu S, Wedderburn LR, Woo P (2012). Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis.. Rheumatology (Oxford), 51(10), 1881 - 1886. doi:10.1093/rheumatology/kes162

    2011

    • Haas JD, Nistala K, Petermann F, Saran N, Chennupati V, Schmitz S, Korn T, Wedderburn LR, Förster R, Krueger A, Prinz I (2011). Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.. PLoS One, 6(5), e20171 - . doi:10.1371/journal.pone.0020171
    • Nistala K, Adams S, Cambrook H, Ursu S, Olivito B, de Jager W, Evans JG, Cimaz R, Bajaj-Elliott M, Wedderburn LR (2011). Th17 cells that undergo plasticity to a Th1 phenotype in human autoimmune arthritis can be detected by the expression of CD161 within the inflamed joint. CLIN EXP RHEUMATOL, 29(2), 449 - 449.
    • Hassan A, Todd A, Nistala K, Pilkington C, Maillard SM (2011). To explore the use of the PedsQL Subjective Questionnaire to assess levels of fatigue in children with Juvenile Dermatomyositis. CLIN EXP RHEUMATOL, 29(2), 438 - 439.
    • Nistala K, Pesenacker A, Wu Q, Ursu S, Wedderburn LR (2011). Regulatory T cells with a pro-inflammatory phenotype express the Th17 marker 'CD161' and are enriched in the joints of children with arthritis.
    • Moncrieffe H, Nistala K, Eaton S, Wedderburn LR (2011). A novel defect: CD39+T cells are enriched in the inflamed joint but do not suppress.

    2010

    • Hunter P, Nistala K, Jina N, Eddaoudi A, Thomson W, Hubank M, Wedderburn LR (2010). Biological Predictors of Extension of Oligoarticular Juvenile Idiopathic Arthritis from Synovial Fluid Cellular Composition and Gene Expression. Arthritis and Rheumatism, 62(3), 896 - 907.
    • Nistala K, Adams S, Cambrook H, Ursu S, Olivito B, de Jager W, Evans JG, Cimaz R, Bajaj-Elliott M, Wedderburn LR (2010). Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment.. Proc Natl Acad Sci U S A, 107(33), 14751 - 14756. doi:10.1073/pnas.1003852107
    • Moncrieffe H, Nistala K, Kamhieh Y, Evans J, Eddaoudi A, Eaton S, Wedderburn LR (2010). High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population.. J Immunol, 185(1), 134 - 143. doi:10.4049/jimmunol.0803474
    • Edwards LA, Nistala K, Mills DC, Stephenson HN, Zilbauer M, Wren BW, Dorrell N, Lindley KJ, Wedderburn LR, Bajaj-Elliott M (2010). Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection.. PLoS One, 5(11), e15398 - . doi:10.1371/journal.pone.0015398

    2009

    • Nistala K, Woo P, Wedderburn LR (2009). Juvenile idiopathic arthritis. In Firestein GS, Budd RC, Harris Jr ED, McInnes IB, Ruddy S, Sergent JS (Ed.), Kelly's Textbook of Rheumatology (pp. 1657 - 1675). : Saunders Elsevier.
    • Edwards LA, Nistala K, Mills DC, Dorrell N, Lindley KJ, Wedderburn L, Bajaj-Elliott M (2009). Campylobacter Jejuni-Mediated Effects On Dendritic Cell IL-12/IL-23 Axis: Impact On T Cell Mediated Immunity.
    • Nistala K, Wedderburn LR (2009). Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis. Rheumatology, 48(6), 602 - 606. doi:10.1093/rheumatology/kep028

    2008

    • Nistala K, Moncrieffe H, Varsani H, Hunter P, Newton K, Wedderburn L (2008). IL-17-producing T cells are enriched in the joints of children with arthritis, and correlate with clinical phenotype.
    • Nistala K, Sala-Soriano E, Hunter P, Wedderburn LR (2008). Synovial Th17 cells in juvenile idiopathic arthritis (JIA) express the Th17 master transcription factor RORC variant 2 and their numbers correlate with CCL20 levels in the joint.
    • Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P, Wedderburn LR (2008). Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis and Rheumatism, 58(3), 875 - 887. doi:10.1002/art.23291
    • Hunter P, Ana N, Nistala K, Eddaoudi A, Hubank M, Wedderbum LR (2008). Molecular tools with which to predict extension to severe disease in oligoarticular juvenile idiopathic arthritis (JIA).

    2007

    • Moncrieffe H, Nistala K, Wedderburn LR (2007). Novel FOXP3 staining and migratory phenotype of synovial regulatory T cells in juvenile idiopathic arthritis (JIA).
    • Nistala K, Babar J, Johnson K, Campbell-Stokes P, Foster K, Ryder C, McDonagh JE (2007). Clinical assessment and core outcome variables are poor predictors of hip arthritis diagnosed by MRI in juvenile idiopathic arthritis.. Rheumatology (Oxford), 46(4), 699 - 702. doi:10.1093/rheumatology/kel401
    • Nistala K, Wedderburn LR (2007). Synovial regulatory T cells in juvenile idiopathic arthritis (JIA) exhibit an inflammatory migratory phenotype.

    2006

    • Nistala K, Johnson K, Campbell-Stokes P, Barbar J, McDonagh JE (2006). MRI based assessment of sacroiliac joints in juvenile idiopathic arthritis (JIA).

    2004

    • Eastwood D, Gilmour KC, Nistala K, Meaney C, Chapel H, Sherrell Z, Webster AD, Davies EG, Jones A, Gaspar HB (2004). Prevalence of SAP gene defects in male patients diagnosed with common variable immunodeficiency. Clin.Exp.Immunol., 137(3), 584 - 588.
    • Eastwood D, Gilmour KC, Nistala K, Gaspar HB, Davies EG, Jones A, Meaney C, Chapel H, Sherrell Z, Webster AD (2004). Prevalence of SAP gene defects in male patients diagnosed with common variable immunodeficiency. Clinical and Experimental Immunology, 137(3), 584 - 588. doi:10.1111/j.1365-2249.2004.02581.x

    2003

    • Nistala K, Hyer W, Halligan S (2003). Jejunal haemorrhage in Henoch-Schönlein syndrome.. Arch Dis Child, 88(5), 434 - .
    • Nistala K, Gaspar HB, Davies G, Gaspar J, Veys P, Thrasher AJ (2003). Late 'top-up' second transplants in severe combined immunodeficiency patients with defective immune function.
    • Nicholl R, Nistala K (2003). Risks of treating infected neonatal lines.. Arch Dis Child Fetal Neonatal Ed, 88(2), F163 - .
    • Nistala K, Nicholl R (2003). Should preterm neonates with a central venous catheter and coagulase negative staphylococcal bacteraemia be treated without removal of the catheter?. Arch Dis Child, 88(5), 458 - 459.

    2002

    • Murray KJ, Nistala K (2002). Coexistent sickle cell disease and juvenile rheumatoid arthritis: 2 cases with delayed diagnosis and severe destructive arthropathy - Reply. J RHEUMATOL, 29(8), 1802 - 1803.

    2001

    • Nistala K, Gilmour KC, Cranston T, Davies EG, Goldblatt D, Gaspar HB, Jones AM (2001). X-linked lymphoproliferative disease: three atypical cases.. Clin Exp Immunol, 126(1), 126 - 130.
    • Nistala K, Murray KJ (2001). Co-existent sickle cell disease and juvenile rheumatoid arthritis. Two cases with delayed diagnosis and severe destructive arthropathy.. J Rheumatol, 28(9), 2125 - 2128.
    • Nistala K , Gilmour KC , Cranston T , Davies EG , Goldblatt D , Gaspar HB , Jones AM (2001). X-linked lymphoproliferative disease: three atypical cases.. Clin.Exp.Immunol., 126, 126 - 130.