Prof Kwee Yong


Personal Profile

Name: Kwee Yong Email:
Title: Prof Tel:
Department: Research Department of Haematology Fax:
Position: Professor of Clinical Haematology Address: , , ,
Research Domain: Personalised Medicine Web Page:  


Research Description

Research Activities

Education Description

UCL Collaborators

External Collaborators



    • Groeneveldt L, Mein G, Garrod R, Jewell AP, Van Someren K, Stephens R, D'Sa SP, Yong KL (2013). A mixed exercise training programme is feasible and safe and may improve quality of life and muscle strength in multiple myeloma survivors.. BMC Cancer, 13, 31 - . doi:10.1186/1471-2407-13-31


    • Stengel C, Cheung CW, Quinn J, Yong K, Khwaja A (2012). Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype.. Leukemia, 26(8), 1761 - 1770. doi:10.1038/leu.2012.69
    • Rabin N, Percy L, Khan I, Quinn J, D'Sa S, Yong KL (2012). Improved response with post-ASCT consolidation by low dose thalidomide, cyclophosphamide and dexamethasone as first line treatment for multiple myeloma.. Br J Haematol, 158(4), 499 - 505. doi:10.1111/j.1365-2141.2012.09188.x
    • Percy LA, Moore SE, Qian W, Dorman J, Rabin N, Watts M, Linch DC, Yong KL (2012). Re-infused lymphocyte dose does not influence disease control following upfront autologous stem cell transplantation for multiple myeloma.. Br J Haematol, 157(4), 494 - 496. doi:10.1111/j.1365-2141.2011.09023.x
    • Glassford J, Kassen D, Quinn J, Stengel C, Kallinikou K, Khwaja A, Yong KL (2012). Inhibition of cell cycle progression by dual phosphatidylinositol-3-kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH translocations. BLOOD CANCER JOURNAL, 2, - . doi:10.1038/bcj.2011.44


    • Quinn J, Percy L, Glassford J, Somana K, Rodriguez-Justo M, Yong K (2010). CD20-positive multiple myeloma - differential expression of cyclins D1 and D2 suggests a heterogeneous disease. British Journal of Haematology, 149(1), 156 - 159.
    • Booth NJ, McQuaid AJ, Sobande T, Kissane S, Agius E, Jackson SE, Salmon M, Falciani F, Yong K, Rustin MH, Akbar AN, Vulmanovic-Stejic M (2010). Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J Immunol, 184(8), 4317 - 4326.
    • Quinn J, Glassford J, Percy L, Munson P, Marafioti T, Rodriguez-Justo M, Yong K (2010). APRIL promotes cell cycle progression in primary multiple myeloma cells: influence of D-type cyclin group and translocation status. Blood, , - .


    • Baou M, Jewell A, Muthurania A, Wickremasinghe RG, Yong KL, Carr R, Marsh P, Murphy JJ (2009). Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells. Leukemia, 23, 986 - 989. doi:10.1038/leu.2008.340
    • Quinn J, Rabin N, Rodriguez-Justo M, Choi D, Yong K (2009). Multiple myeloma presenting with spinal cord compression during pregnancy. , 88(2), 181 - 182.


    • Kyriakou C, Rabin N, Pizzey A, Nathwani A, Yong K (2008). Short term homing of human bone marrow derived mesenchymal stem cells (hMSCs) in a xenogeneic animal model is influenced by animal age and is increased by enforced expression of CXCR4. Haematologica, 93(10), 1457 - 1465.


    • Rasaiyaah J, Yong K, Katz DR, Kellam P, Chain BM (2007). Dendritic cells and myeloid leukaemias: plasticity and commitment in cell differentiation. British Journal of Haematology, 138(3), 281 - 290.
    • Rabin N, Kyriakou C, Coulton L, Gallagher OM, Buckle C, Benjamin R, Singh N, Glassford J, Otsuki T, Nathwani AC, Croucher PI, Yong KL (2007). A new xenograft model of myeloma bone disease demonstrating the efficacy of human mesenchymal stem cells expressing osteoprotegerin by lentiviral gene transfer.. Leukemia, , - .
    • Glassford J, Rabin N, Lam EW, Yong KL (2007). Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells.. Br J Haematol, 139(2), 243 - 254. doi:10.1111/j.1365-2141.2007.06789.x


    • Kyriakou CA, Yong KL, Benjamin R, Pizzey A, Dogan A, Singh N, Davidoff AM, Nathwani AC (2006). Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFlk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model.. The Journal of Gene Medicine, 8(3), 253 - 264.
    • Morsi H, Yong KL, Jewell AP (2006). Preferential survival of acute lymphoblastic leukemia cells at 33 degrees C is associated with up-regulation of bcl-2.. Leukemia and Lymphoma, 47(6), 1117 - 1122.


    • Kyriakou C, Thomson K, D'Sa S, Flory A, Hanslip J, Goldstone AH, Yong KL (2005). Low-dose thalidomide in combination with oral weekly cyclophosphamide and pulsed dexamethasone is a well tolerated and effective regimen in patients with relapsed and refractory multiple myeloma.. British Journal of Haematology, 129(6), 763 - 770.
    • Rew SB, Peggs K, Sanjuan I, Pizzey AR, Koishihara Y, Kawai S, Kosaka M, Ozaki S, Chain B, Yong KL (2005). Generation of potent antitumor CTL from patients with multiple myeloma directed against HM1.24.. Clinical Cancer Research, 11, 3377 - 3384. doi:10.1158/1078-0432.CCR-04-0650
    • Abelman W, Virchis A, Yong K (2005). Extramedullary myeloma representing as a pericardial effusion with tamponade: two case reports and a further review of 19 cases in the literature.. Leukemia and Lymphoma, 46(1), 137 - 142.
    • Porakishvili N, Kulikova N, Jewell AP, Youinou PY, Nedelec S, Yong K, Nathwani A, Heelan B, Duke V, Hamblin TJ, Wallace P, Ely P, Clark EA, Lydyard PM (2005). CD180 is more highly expressed by B cell chronic lymphocytic leukaemia (B-CLL) cells using IgVh mutated than those using IgVh unmutated genes. British Journal of Haematology, 131(3), 313 - 319.


    • Morsi H, Yong KL, Jewell AP (2004). Evaluation of the Taguchi methods for the simultaneous assessment of the effects of multiple variables in the tumour microenvironment.. International Seminars in Surgical Oncology, 1(1), 7 - .
    • D'Sa S, Yong K, Kyriakou C, Bhattacharya S, Peggs KS, Foulkes B, Watts MJ, Ings SJ, Ardeshna KM, Goldstone AH, Williams CD (2004). Etoposide, methylprednisolone, cytarabine and cisplatin successfully cytoreduces resistant myeloma patients and mobilizes them for transplant without adverse effects.. British Journal of Haematology, 125(6), 756 - 765.
    • Avivi I, Chakrabarti S, Milligan D, Waldmann H, Hale G, Osman H, Ward K, Fegan C, Yong K, Goldstone A, Linch D, Mackinnon S (2004). Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 10(3), 186 - 194.
    • Porakishvili N, Kardava L, Jewell AP, Yong K, Glennie MJ, Akbar A, Lydyard PM (2004). Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway.. Haematologica, 89(4), 435 - 443.
    • Burns SO, Hardy SJ, Buddle J, Yong KL, Jones GE, Thrasher AJ (2004). Maturation of DC is associated with changes in motile characteristics and adherence. Cell Motility and the Cytoskeleton, 57, 118 - 132.
    • Ahmed F, Ings SJ, Pizzey AR, Blundell MP, Thrasher AJ, Ye HT, Fahey A, Linch DC, Yong KL (2004). Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model. Blood, 103(6), 2079 - 2087. doi:10.1182/blood-2003-06-1770


    • Ahmed F, Ings SJ, Pizzey AR, Blundell MP, Thrasher AJ, Ye HT, Fahey A, Linch DC, Yong KL (2003). Impaired bone marrow homing of cytokine activated CD34+ cells in the NOD/SCID model. BLOOD, , - .
    • Turner MR, Warren JD, Jacobs JM, Groves MJ, Yong K, Honan WP, Thomas PK, Reilly MM (2003). Microvasculitic paraproteinaemic polyneuropathy and B-cell lymphoma. Journal of the Peripheral Nervous System, 8(2), 100 - 107.
    • Peggs KS, Mackinnon S, Williams CD, D'Sa S, Thuraisundaram D, Kyriacou C, Morris EC, Hale G, Waldmann H, Linch DC, Goldstone AH, Yong K (2003). Reduced intensity transplantation with in vivo T-cell depletion and adjuvant dose-escalating donor lymphocyte infusions for chemotherapy-senstive myeloma: limited efficacy of graft-versus-tumor activity.. Biology of Blood and Marrow Transplantation, 9(4), 257 - 265. doi:10.1053/bbmt.2003.50009
    • Borthwick NJ, Akbar AN, Buckley C, Pilling D, Salmon M, Jewell AP, Yong KL (2003). Transendothelial migration confers a survival advantage to activated T lymphocytes: role of LFA-1/ICAM-1 interactions. Clinical and Experimental Immunology, 134, 246 - 252.
    • D'Sa S, Peggs K, Pizzey A, Verfuerth S, Thuraisundaram D, Watts M, White H, Hale G, Waldmann H, Goldstone A, MACKINNON S, Yong K (2003). T- and B-cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T-cell-depleted, reduced-intensity allogeneic stem cell transplantation with an alemtuzumab-containing conditioning regimen followed by escalated donor ly. British Journal of Haematology, 123(2), 309 - 322.
    • PEGGS KS, Verfuerth S, D'Sa S, Yong K, MACKINNON S (2003). Assessing diversity: immune reconstitution and T-cell receptor BV spectratype analysis following stem cell transplantation. British Journal of Haematology, 120, 154 - 165.


    • Peggs KS, Paneesha S, Kottaridis PD, Chakraverty RK, Tobias G, Reilly M, Mahendra P, Yong K (2002). Peripheral blood stem cell transplantation for POEMS syndrome.. Bone Marrow Transplantation, 30(6), 401 - 404.
    • Chakrabarti S, Avivi I, MACKINNON S, Ward K, KOTTARIDIS PD, Osman H, Waldmann H, Hale G, Fegan CD, Yong K, GOLDSTONE AH, Linch DC, Milligan DW (2002). Respiratory virus infections in transplant recipients after reduced-intensity conditioning with Campath-1H: high incidence but low mortality. British Journal of Haematology, 119(4), 1125 - 1132.
    • Watts MJ, Somervaille TC, Ings SJ, Ahmed F, Khwaja A, Yong K, Linch DC (2002). Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices.. British Journal of Haematology, 118(1), 117 - 123.
    • Perez-Simon JA, Kottaridis PD, Martino R, Craddock C, Caballero D, Chopra R, Garcia-Conde J, Milligan DW, Schey S, Urbano-Ispizua A, Parker A, Leon A, Yong K, Sureda A, Hunter A, Sierra J, Goldstone AH, Linch DC, San Miguel JF, Mackinnon S Spanish and United Kingdom Collaborative Groups for Nonmyeloablative TRANSPLANTATION (2002). Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders.. Blood, 100(9), 3121 - 3127.
    • Chakraverty R, Peggs K, Chopra R, Milligan D, Kottaridis P, Verfuerth S, Geary J, Thuraisundaram D, Branson K, Mahendra P, Craddock C, Parker A, Hunter A, Hale G, Waldmann H, Williams C, Yong K, Linch DC, Goldstone A, Mackinnon S (2002). Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen.. Blood, 99(3), 1071 - 1078.
    • Yong KL, Fahey A, Pizzey A, Linch DC (2002). Influence of cell cycling and cell division on transendothelial migration of CD34+ cells.. British Journal of Haematology, , - .
    • Yong KL, Fahey A, Pahal G, Linch DC, Pizzey A, Thomas NSB, Jauniaux E, Kinnon C, Thrasher AJ (2002). Fetal haemapoietic cells display enhanced migration across endothelium. British Journal of Haematology, 116, 392 - 400. doi:10.1046/j.1365-2141.2002.03273.x
    • Chakrabarti S, Mackinnon S, Chopra R, Kottaridis PD, Peggs K, O'Gorman P, Chakraverty R, Marshall T, Osman H, Mahendra P, Craddock C, Waldmann H, Hale G, Fegan CD, Yong K, Goldstone AH, Linch DC, Milligan DW (2002). High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.. Blood, 99(12), 4357 - 4363.


    • Porakishvili N, Roschupkina T, Kalber T, Jewell AP, Patterson K, Yong K, Lydyard PM (2001). Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B- chronic lymphocytic leukaemia (B-CLL). Clinical and Experimental Immunology, 126(1), 29 - 36.
    • Chakraverty R, Rabin N, Peggs K, Robinson S, Duncan JR, Yong K (2001). Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation.. Bone Marrow Transplantation, 27(11), 1215 - 1217.


    • Noble KE, Harkness D, Yong KL (2000). Interleukin 10 regulates cellular responses in monocyte/endothelial cell co-cultures.. British Journal of Haematology, 108(3), 497 - 504.
    • Peggs KS, Ings SJ, Kottaridis PD, Yong K, Williams CD, Goldstone AH, Mackinon S (2000). Cytomegalovirus infection and disease after autologous CD34-selected peripheral blood stem cell transplantation for multiple myeloma: no evidence of increased incidence based on polymerase-chain-reaction monitoring.. Blood, 96(1), 369 - 370.


    • Yong KL (1999). Blood and its disorders. In Westwood OMR (Ed.), The scientific basis for health care (pp. 417 - 432). : C.V. Mosby.
    • Yong KL, Jewell AP (1999). Diseases of the Gut, Liver and Biliary Tract. In Westwood OMR (Ed.), The scientific basis for health care (pp. 461 - 478). : C.V. Mosby.
    • Noble KE, Wickremasinghe RG, DeCornet C, Panayiotidis P, Yong KL (1999). Monocytes stimulate expression of the Bcl-2 family member, A1, in endothelial cells and confer protection against apoptosis.. The Journal of Immunology, 162(3), 1376 - 1383.
    • Yong K, Fahey A, Reeve L, Nicholls C, Thomas NS, Pizzey A, Ings SJ, Watts MJ, Linch DC (1999). Cord blood progenitor cells have greater transendothelial migratory activity and increased responses to SDF-1 and MIP-3beta compared with mobilized adult progenitor cells.. , , - .
    • Noble KE, Wickremasinghe RG, DeCornet C, Panayiotidis P, Yong KL (1999). Monocytes stimulate expression of the Bcl-2 family mamber ,A1, in endothelia cells and confer protection against apoptosis. The Journal of Immunology, 162(3), 1376 - 1383.
    • Porakishvili N, Roshupkina T, Jewell AP, Patterson K, Yong K, Lydyard PM (1999). Circulating CD4+ cells in patients with B-chronic lymphocytic leukaemia (B-CLL) express perforin (PF) and serine esterase (SE). Immunology, 98(Suppl), 20 - .
    • Yong KL, Jewell AP (1999). Diseases of the Central Nervous System. In Westwood OMR (Ed.), The scientific basis for health care (pp. 525 - 538). : C.V. Mosby.
    • Yong KL, Jewell AP (1999). Diseases of the endocrine system. In Westwood OMR (Ed.), The scientific basis for health care (pp. 479 - 492). : C.V. Mosby.


    • Yong KL, Watts M, Shaun T, Sullivan A, Ings S, Linch DC (1998). Transmigration of CD34+ cells across specialized and nonspecialized endothelium requires prior activation by growth factors and is mediated by PECAM-1 (CD31). Blood, 91(4), 1196 - 1205.
    • Grundy JE, Lawson KM, MacCormac LP, Fletcher JM, Yong KL (1998). Cytomegalovirus-infected endothelial cells recruit neutrophils by the secretion of C-X-C chemokines and transmit virus by direct neutrophil-endothelial cell contact and during neutrophil transendothelial migration. The Journal of Infectious Diseases, 177, 1465 - 1474.


    • Jewell AP, Yong KL (1997). Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukaemia.. Acta Haematologica, 97(1), 67 - 72.
    • Craigen JL, Yong KL, Jordan NJ, MacCormac LP, Westwick J, Akbar AN, Grundy JE (1997). Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration.. Immunology, 92(1), 138 - 145.
    • Borthwick NJ, Akbar AN, MacCormac LP, Salmon M, Yong KL (1997). Selective migration of highly differentiated primed T cells across human umbilical vein endothelial cells.. Biochemical Society Transactions, 25(2), 258S - .
    • Borthwick NJ, Akbar AN, MacCormac LP, Lowdell M, Craigen JL, Hassan I, Grundy JE, Salmon M, Yong KL (1997). Selective migration of highly differentiated primed T cells, defined by low expression of CD45RB, across human umbilical vein endothelial cells: effects of viral infection on transmigration.. Immunology, 90(2), 272 - 280.


    • Yong KL (1996). Granulocyte colony-stimulating factor (G-CSF) increases neutrophil migration across vascular endothelium independent of an effect on adhesion: comparison with granulocyte-macrophage colony-stimulating factor (GM-CSF).. British Journal of Haematology, 94(1), 40 - 47.
    • Pedersen TL, Yong K, Pedersen JO, Hansen NE, Dano K, Plesner T (1996). Impaired migration in vitro of neutrophils from patients with paroxysmal nocturnal haemoglobinuria.. British Journal of Haematology, 95(1), 45 - 51.
    • Noble KE, Panayiotidis P, Collins PW, Hoffbrand AV, Yong KL (1996). Monocytes induce E-selectin gene expression in endothelial cells: role of CD11/CD18 and extracellular matrix proteins.. European Journal of Immunology, 26(12), 2944 - 2951.


    • Collins PW, Noble KE, Reittie JR, Hoffbrand AV, Pasi KJ, Yong KL (1995). Induction of tissue factor expression in human monocyte/endothelium cocultures.. British Journal of Haematology, 91(4), 963 - 970.


    • Khwaja A, Addison IE, Johnson B, Yong K, Linch DC (1994). Interleukin-3 administration enhances human monocyte function in vivo.. British Journal of Haematology, 88(3), 515 - 519.
    • Jewell AP, Worman CP, Lydyard PM, Yong KL, Giles FJ, Goldstone AH (1994). Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo.. British Journal of Haematology, 88(2), 268 - 274.
    • Jewell AP, Yong KL, Worman CP, Tsakona CP, Giles FJ, Goldstone AH (1994). Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL.. British Journal of Haematology, 86(2), 441 - 443.
    • Roberts PJ, Khwaja A, Lie AK, Bybee A, Yong K, Thomas NS, Linch DC (1994). Differentiation-linked changes in tyrosine phosphorylation, functional activity, and gene expression downstream from the granulocyte-macrophage colony-stimulating factor receptor.. Blood, 84(4), 1064 - 1073.


    • Roberts PJ, Yong KL, Khwaja A, Johnson BV, Pizzey AR, Carver JE, Addison IE, Linch DC (1993). Pentoxifylline at clinically achievable levels inhibits FMLP-induced neutrophil responses, but not priming, upregulation of cell-adhesion molecules, or migration induced by GM-CSF.. , , - .
    • Yong KL, Linch DC (1993). Granulocyte-macrophage-colony-stimulating factor differentially regulates neutrophil migration across IL-1-activated and nonactivated human endothelium.. The Journal of Immunology, 150(6), 2449 - 2456.


    • Khwaja A, Yong K, Jones HM, Chopra R, McMillan AK, Goldstone AH, Patterson KG, Matheson C, Ruthven K, Abramson SB, et AL (1992). The effect of macrophage colony-stimulating factor on haemopoietic recovery after autologous bone marrow transplantation.. British Journal of Haematology, 81(2), 288 - 295.
    • Jewell AP, Yong KL, Worman CP, Giles FJ, Goldstone AH, Lydyard PM (1992). Cytokine induction of leucocyte adhesion molecule-1 (LAM- 1) expression on chronic lymphocytic leukaemia cells.. Leukemia, 6(5), 400 - 404.
    • Yong KL, Rowles PM, Patterson KG, Linch DC (1992). Granulocyte-macrophage colony-stimulating factor induces neutrophil adhesion to pulmonary vascular endothelium in vivo: role of beta 2 integrins.. Blood, 80(6), 1565 - 1575.
    • Yong KL, Linch DC (1992). Differential effects of granulocyte- and granulocyte-macrophage colony-stimulating factors (G- and GM-CSF) on neutrophil adhesion in vitro and in vivo.. European Journal of Haematology, 49(5), 251 - 259.
    • Yong K, Salooja N, Donahue RE, Hegde U, Linch DC (1992). Human macrophage colony-stimulating factor levels are elevated in pregnancy and in immune thrombocytopenia.. Blood, 80(11), 2897 - 2902.


    • Yong K, Cohen H, Khwaja A, Jones HM, Linch DC (1991). Lack of effect of granulocyte-macrophage and granulocyte colony-stimulating factors on cultured human endothelial cells.. Blood, 77(8), 1675 - 1680.
    • Khwaja A, Johnson B, Addison IE, Yong K, Ruthven K, Abramson S, Linch DC (1991). In vivo effects of macrophage colony-stimulating factor on human monocyte function.. British Journal of Haematology, 77(1), 25 - 31.
    • Yong K, Addison IE, Johnson B, Webster AD, Linch DC (1991). Role of leucocyte integrins in phagocyte responses to granulocyte-macrophage colony stimulating factor (GM-CSF): in vitro and in vivo studies on leucocyte adhesion deficiency neutrophils.. British Journal of Haematology, 77(2), 150 - 157.


    • Khwaja A, Roberts PJ, Jones HM, Yong K, Jaswon MS, Linch DC (1990). Isoquinolinesulfonamide protein kinase inhibitors H7 and H8 enhance the effects of granulocyte-macrophage colony-stimulating factor (GM-CSE) on neutrophil function and inhibit GM-CSF receptor internalization.. Blood, 76(5), 996 - 1003.
    • Yong K, Khwaja A (1990). Leucocyte cellular adhesion molecules.. Blood Reviews, 4(4), 211 - 225.


    • O'Donnell CJ, Yong K, Joplin GF (1989). Assessment of computed tomographic artefact in the pituitary fossa following needle implantation of radioactive rods.. Clinical Radiology, 40(2), 154 - 157.


    • Giles FJ, Singer CR, Gray AG, Yong KL, Brozovic M, Davies SC, Grant IR, Hoffbrand AV, Machin SJ, Mehta AB, et AL (1988). Alpha-interferon therapy for essential thrombocythaemia.. The Lancet, 2(8602), 70 - 72.