Dr J.p. Martinez-Barbera

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Personal Profile

Name: J.p. Martinez-Barbera Email: j.martinez-barbera@ucl.ac.uk
Title: Dr Tel: 020 7905 2821
Department: ICH Development Bio & Cancer Prog Fax:
Position: Wellcome Trust Research Fellow Address: Birth Defects Research Centre, Institute of Child Health UCL, 30 Guildford Street, London, WC1N 1EH
Research Domain: Basic Life Sciences, Neuroscience, Populations & Lifelong Health, Reproduction & Development, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

Profile

Research Description

My research program aims to understand normal development and pathology of the brain and associated structures, such as the pituitary gland and eyes. Developmental disorders of the brain have an overall significant prevalence in humans and include congenital defects as well as childhood brain tumours. For the last several years my group has provided important insights into normal brain and pituitary development. In addition, we have contributed significantly to the understanding of the aetiology and pathogenesis of human congenital hypopituitarism and pituitary tumours (eg craniophryngioma). Our aim is to reveal the aetiology and pathogenesis of these human disorders using a multidisciplinary approach. The Institute of Child Health is perfectly placed to carry out this research due to its strong links to Great Ormond Street Hospital for Children (GOSH). My group collaborates with several clinicians from GOSH, including endocrinologists, neuropathologists and oncologists.

Specific aims of my research are: (1) To identify the genetic basis and to determine the mechanisms underlying developmental disorders of the brain and pituitary gland, as a means of understanding the corresponding human defects and to establish new diagnostic and prognostic methods in humans; (2) To develop new methods to treat pituitary tumours (eg craniopharyngioma) using our unique genetic tools with the ultimate goal of translating the findings into the clinic for the benefit of the patients.

Current ongoing research:

1.Identification of the genetic basis of developmental brain and pituitary disorders. We have identified a large number of genes that when mutated result in brain defects in mice and proven that some of them are relevant for human conditions. However, the genetic causes are still missing for the majority of the cases.

2. Determining the mechanisms that lead from genes to brain and pituitary disorders. We need to understand gene function during normal development if we aim to reveal how mutant genes lead to human disease. This knowledge can be translated into improved management of the patients. We use a multidisciplinary approach to understand gene function in normal and abnormal embryonic development.

3. Understanding a novel model involved in pituitary oncogenesis. We have recently revealed a paracrine model whereby mutated pituitary stem cells induce tumours. We are studying the molecular and cellular mechanisms of this model, which may have broader implications in the field of oncogenesis.

4. Development of new methods to treat pituitary tumours:  There is a real clinical need to improve treatments for human tumours such as childhood craniopharyngioma. Our research has identified several pathways that are elevated in these tumours, suggesting that the inhibition using specific inhibitors could lead to novel treatments. We are using unique genetic tools that we have developed to perform pre-clinical studies. Specific inhibitors against several pathways are being tested in our models for childhood craniopharyngioma.





Research Activities

Embryonic stem cell research

Signalling pathways involved in normal pituitary development and in tumorigenesis

Transcription factors in early forebrain and pituitary development

Education Description



1993-1999. Part-time
lecturer (90 hours/year) at the University of Cadiz (Spain). I
was
solely responsible for two of the courses taught in the Department of
Biochemistry
and Molecular Biology: (i) ”Molecular Biology and Biotechnology
(1993-1995);
(ii) Biochemistry (1996-1999). This teaching activity involved
both practical
and theoretical courses. From 1996, during my post-doctoral
training in Sweden,
until 1998, I went back to Spain for eight weeks each year
to deliver my
lectures. Eventually, I resigned from this position in Spain in
1999, since I
was fully committed to research in UK.



2006-.
Every January, I have
delivered a two-hour
lecture entitled:” Axis formation in the mouse” in the BSc
course organised
by Prof. Claudio Stern (Mechanisms of Development).

















UCL Collaborators

Prof Mehul Dattani; Dr Mike Hubank

External Collaborators

Publications

    2014

    • Balmer GM, Bollini S, Dubé KN, Martinez-Barbera JP, Williams O, Riley PR (2014). Dynamic haematopoietic cell contribution to the developing and adult epicardium.. Nat Commun, 5, 4054 - . doi:10.1038/ncomms5054

    2013

    • Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, Dattani MT, Pevny LH, Martinez-Barbera JP (2013). Sox2(+) Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential.. Cell Stem Cell, 13(4), 433 - 445. doi:10.1016/j.stem.2013.07.004
    • Andoniadou CL, Martinez-Barbera JP (2013). Developmental mechanisms directing early anterior forebrain specification in vertebrates.. Cell Mol Life Sci, 70(20), 3739 - 3752. doi:10.1007/s00018-013-1269-5
    • McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto KH, Nagano M, Shigeyoshi Y, Pfeifer M, Hulse T, Buchanan CR, Pitteloud N, Martinez-Barbera JP, Dattani MT (2013). Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.. J Clin Endocrinol Metab, 98(3), E547 - E557. doi:10.1210/jc.2012-3067
    • Webb EA, Almutair A, Kelberman D, Bacchelli C, Chanudet E, Lescai F, Andoniadou CL, Banyan A, Alsawaid A, Alrifai MT, Alahmesh MA, Balwi M, Mousavy-Gharavy SN, Lukovic B, Burke D, McCabe MJ, Kasia T, Kleta R, Stupka E, Beales PL, Thompson DA, Chong WK, Alkuraya FS, Martinez-Barbera JP, Sowden JC, Dattani MT (2013). ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies.. Brain, , - . doi:10.1093/brain/awt218
    • Schoenmakers N, Sun Y, Bak B, van Trotsenburg ASP, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Gharavy SNM, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TME, Hokken-Koelega ACS, Del Blanco DG, Rangasami JJ, Ruivenkamp CAL, Laros JFJ, Kriek M, Kant SG, Bosch CAJ, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GCJ, Pereira AM, den Dunnen JT, Wade MG, Breuning MH, Hennekam RC, Dattani MT, Wit JM, Bernard DJ, Chatterjee K (2013). Loss-of-function mutations in the immunoglobulin superfamily member 1 gene (IGSF1) cause a novel, X-linked syndrome of central hypothyroidism and testicular enlargement.

    2012

    • Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Gharavy SN, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TM, Hokken-Koelega AC, Del Blanco DG, Rangasami JJ, Ruivenkamp CA, Laros JF, Kriek M, Kant SG, Bosch CA, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GC, Pereira AM, den Dunnen JT, Wade MG, Breuning MH, Hennekam RC, Chatterjee K, Dattani MT, Wit JM, Bernard DJ (2012). Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement.. Nat Genet, 44(12), 1375 - 1381. doi:10.1038/ng.2453
    • Sun Y, Ruivenkamp CAL, Laros JFJ, Kriek M, Kant SG, Bosch CAJ, Den Dunnen JTD, Breuning MH, Bak B, Bernard DJ, Schoenmakers N, Voshol P, Chatterjee K, Van Trotsenburg ASP, Vulsma T, Kempers MJ, Hennekam RC, Oostdijk W, Stokvis-Brantsma WH, Wit JM, Cambridge E, White JK, Le Tissier P, Gharavy SNM, Martinez-Barbera JP, Persani L, Campi I, Beck-Peccoz P, Bonomi M, Zhu H, Davis TME, Hokken-Koelega ACS, Del Blanco DG, Rangasami JJ, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GCJ, Pereira AM, Wade MG, Dattani MT (2012). Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nature Genetics, 44(12), 1375 - 1381. doi:10.1038/ng.2453
    • Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH, Dattani MT, Martinez-Barbera JP (2012). Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma.. Acta Neuropathol, 124(2), 259 - 271. doi:10.1007/s00401-012-0957-9
    • Reynaud R, Jayakody SA, Monnier C, Saveanu A, Bouligand J, Guedj AM, Simonin G, Lecomte P, Barlier A, Rondard P, Martinez-Barbera JP, Guiochon-Mantel A, Brue T (2012). PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.. J Clin Endocrinol Metab, 97(6), E1068 - E1073. doi:10.1210/jc.2011-3056
    • West EL, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M, Ali RR (2012). Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors.. Stem Cells, 30(7), 1424 - 1435. doi:10.1002/stem.1123
    • Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP (2012). SOX2 regulates the hypothalamic-pituitary axis at multiple levels.. J Clin Invest, 122(10), 3635 - 3646. doi:10.1172/JCI64311

    2011

    • McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D, Farooqi IS, Raza J, Walker J, Kavanaugh SI, Tsai PS, Pitteloud N, Martinez-Barbera JP, Dattani MT (2011). Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.. J Clin Endocrinol Metab, 96(10), E1709 - E1718. doi:10.1210/jc.2011-0454
    • Alatzoglou KS, Andoniadou CL, Kelberman D, Buchanan CR, Crolla J, Arriazu MC, Roubicek M, Moncet D, Martinez-Barbera JP, Dattani MT (2011). SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours.. Hum Mutat, 32(12), 1376 - 1380. doi:10.1002/humu.21606
    • Jayakody SA, Andoniadou C, Signore M, Gaston-Massuet C, Pevny LH, Brue T, Martinez-Barbera J-P (2011). Investigating genetic factors underlying hypopituitarism and septo-optic dysplasia in humans.
    • Norris FC, Cleary JO, Modat M, Sinclair B, Mccue K, Wells JA, Martinez-Barbera JP, Brander S, Fisher E, Scambler PJ, Ourselin S, Lythgoe MF (2011). Mouse phenotyping using high resolution 3D microscopic magnetic resonance imaging.
    • Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP (2011). HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.. Development, 138(22), 4931 - 4942. doi:10.1242/dev.066597
    • Dattani MT, Martinez-Barbera JP (2011). The future of genomic endocrinology.. Front Endocrinol (Lausanne), 2, 11 - . doi:10.3389/fendo.2011.00011
    • Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP (2011). Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.. Proc Natl Acad Sci U S A, 108(28), 11482 - 11487. doi:10.1073/pnas.1101553108
    • Cleary JO, Modat M, Norris FC, Price AN, Jayakody SA, Martinez-Barbera JP, Greene ND, Hawkes DJ, Ordidge RJ, Scambler PJ, Ourselin S, Lythgoe MF (2011). Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping.. Neuroimage, 54(2), 769 - 778. doi:10.1016/j.neuroimage.2010.07.039

    2010

    • McCabe MJ, Tziaferi V, Gaston-Massuet C, Gregory LC, Walker J, Tsai PS, Pitteloud N, Martinez-Barbera JP, Dattani MT (2010). Mutations in the Gene Encoding Fibroblast Growth Factor 8, FGF8, Are Associated with Complex Midline and Hypothalamo-Pituitary Defects..
    • Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody S, Charolidi N, Le Tissier P, Dattani M, Martinez-Barbera JP (2010). Enhancement of the Canonical Wnt Pathway in Rathke's Pouch Results in Pituitary Tumours Reminiscent of Human Adamantinomatous Craniopharyngioma.

    2009

    • Pauws E, Hoshino A, Bentley L, Prajapati S, Keller C, Hammond P, Martinez-Barbera J-P, Moore GE, Stanier P (2009). Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Human Molecular Genetics, 18(21), 4171 - 4179.
    • Longbottom R, Fruttiger M, Douglas RH, Martinez-Barbera JP, Greenwood J, Moss SE (2009). Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.. Proc Natl Acad Sci U S A, 106(44), 18728 - 18733. doi:10.1073/pnas.0902593106
    • Gaston-Massuet C, Martinez-Barbera JP, Kelberman D, Dattani M (2009). Absence of SIX3 mutations in patients with congenital hypopituitarism. American Journal of Medical Genetics, Part A, 149(12), 2874 - 2876. doi:10.1002/ajmg.a.33103
    • Pauws E, Hoshino A, Bentley L, Prajapati S, Keller C, Martinez-Barbera JP, Moore GE, Stanier P (2009). Loss of Tbx22 causes submucous cleft palate, ankyloglossia and choanal atresia.
    • Andoniadou CL, Gaston-Massuet C, Martinez-Barbera JP (2009). Hesx1 antagonises canonical Wnt signalling in anterior forebrain and pituitary gland.
    • Gaston-Massuet C, Kelberman D, Dattani M, Martinez-Barbera JP (2009). Absence of SIX3 mutations in patients with congenital hypopituitarism. Am J Med Genet A, 149A(12), 2874 - 2876. doi:10.1002/ajmg.a.33103
    • Charolidi N, Cynthia LA, Signore M, Richard GJ, Martinez-Barbera JP (2009). Developmental regulatory targets of the homeobox transcription factor HESX1. doi:10.1016/j.mod.2009.06.220
    • de Melo IS, Iglesias C, Benítez-Rondán A, Medina F, Martínez-Barberá JP, Bolívar J (2009). NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic activity in human cells.. Biochim Biophys Acta, 1793(12), 1876 - 1885. doi:10.1016/j.bbamcr.2009.10.011

    2008

    • Abrahamsen B, Zhao J, Asante CO, Cendan CM, Marsh S, Martinez-Barbera JP, Nassar MA, Dickenson AH, Wood JN (2008). The cell and molecular basis of mechanical, cold, and inflammatory pain. Science, 321(5889), 702 - 705.
    • Kelberman D, de Castro SC, Huang S, Crolla JA, Palmer R, Gregory JW, Taylor D, Cavallo L, Faienza MF, Fischetto R, Achermann JC, Martinez-Barbera JP, Rizzoti K, Lovell-Badge R, Robinson IC, Gerrelli D, Dattani MT (2008). SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development. J Clin Endocrinol Metab, 93(5), 1865 - 1873. doi:10.1210/jc.2007-2337
    • Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JMAAM-B, J P (2008). Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Developmental Biology, , - . doi:10.1016/j.ydbio.2008.08.008
    • Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M, Martinez-Barbera JP (2008). DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim.Biophys.Acta, 1783(1), 131 - 143. doi:10.1016/j.bbamcr.2007.08.010
    • Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT, Martinez-Barbera JP (2008). Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism.. Dis Model Mech, 1(4-5), 241 - 254. doi:10.1242/dmm.000711

    2007

    • Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP (2007). Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development, 134(8), 1499 - 1508. doi:10.1242/dev.02829
    • Val P, Martinez-Barbera JP, Swain A (2007). Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development, 134(12), 2349 - 2358.

    2006

    • Bort R, Signore M, Tremblay K, Martinez-Barbera JPAZ, K S (2006). ). Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Developmental Biology, 290, 44 - 56.
    • Sajed E, Gaston-Massuet C, Signore M, Dattani M, Martinez-Barbera JP (2006). Role of the homeobox gene Hesx1/HESX1 in forebrain and pituitary formation in mouse and humans.
    • Withington SL, Scott AN, Saunders DN, Lopes Floro K, Preis JL, Michalicek J, Maclean K, Sparrow DB, Martinez-Barbera JPAD, S L (2006). Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Developmental Biology, 294, 67 - 82.

    2005

    • Woods KS, Cundall M, Turton J, Rizotti K, Mehta A, Palmer R, Wong J, Chong WK, Al-Zyoud M, El-Ali M, Otonkoski T, Martinez-Barbera JP, Thomas PQ, Robinson IC, Lovell-Badge R, Woodward KJ, Dattani MT (2005). Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism. Am J Hum Genet, 76(5), 833 - 849. doi:10.1086/430134
    • Ivanova A, Signore M, Caro N, Greene ND, Copp AJ, Martinez-Barbera JP (2005). In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis, 43(3), 129 - 135.
    • Weninger WJ, Floro KL, Bennett MB, Withington SL, Preis JI, Barbera JPM, Mohun TJ, Dunwoodie SL (2005). Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development, 132(6), 1337 - 1348.
    • Signore M, Sajedi S, Gaston-Massuet C, Dattani M, Martinez-Barbera JP (2005). Role of the Homeobox Gene Hesx1 in forebrain and pituitary formation in mouse and human.
    • Ragge NK, Brown AG, Poloschek CM, Lorenz B, Henderson RA, Clarke MP, Russell-Eggitt I, Fielder A, Gerrelli D, Martinez-Barbera JP, Ruddle P, Hurst J, Collin JR, Salt A, Cooper ST, Thompson PJ, Sisodiya SM, Williamson KA, Fitzpatrick DR, van Heyningen V, Hanson IM (2005). Heterozygous mutations of OTX2 cause severe ocular malformations.. The American Journal of Human Genetics, 76(6), 1008 - 1022. doi:10.1086/430721

    2004

    • Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS (2004). Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development, (131), 797 - 806.
    • Rana R, Martinez-Barbera JP, Rodriguez TA, Lynch D, Hirst E, Smith JC, Beddington RSP (2004). Targeted deletion of the novel cytopalsmic dyelinmD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. Development, (131), 4999 - 5007.

    2003

    • Guo Y, Chan R, Ramsey H, Li W, Xie X, Shelley WC, Martinez-Barbera JP, Bort B, Zaret K, Yoder M, Hromas R (2003). The homeoprotein Hex is required for hemangioblast differentiation.. Blood, 102(7), 2428 - 2435. doi:10.1182/blood-2003-02-0634
    • Simeone A, Martinez-Barbera JP, Puelles E, Acampora D (2003). Role of Otx transcription factors in brain development. In (Ed.), Advances in Developmental Biology and Biochemistry (pp. 207 - 250). : Elsevier. doi:10.1016/S1569-1799(03)13007-9

    2002

    • Gogoi RN, Schubert FR, Martinez-Barbera JP, Acampora D, Simeone A, Lumsden A (2002). The pair-type homeobox gene Dmbx1marks the midbrain and pretectum. Mechanisms of Development, 114, 213 - 217.
    • Martinez-Barbera JP, Rodriguez TA, Greene NDE, Weninger WJ, Simeone A, Copp AJ, Beddington R, Dunwoodie S (2002). Folic acid prevents exencephaly in Cited2 deficient mice. Human Molecular Genetics, 11(3), 283 - 293. doi:10.1093/hmg/11.3.283

    2001

    • Martinez-Barbera JPABRS (2001). Getting your head around Hex and Hesx1: forebrain formation in mouse. International Journal of Developmental Biology, 45, 327 - 336.
    • Boyl PP, Signore M, Acampora D, Martinez-Barbera JP, Ilengo C, Annino A, Corte G, Simeone A (2001). Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR.. Development, 128(15), 2989 - 3000.
    • Pilo Boyl P, Signore M, Annino A, Martinez-Barbera JP, Acampora DASA (2001). Otx genes in development and evolution of the vertebrate brain.. International Journal of developmental Neuroscience, 19, 353 - 363.
    • Acampora D, Pilo Boyl P, Signore M, Martinez-Barbera JP, Ilengo C, Puelles E, Annino A, Reichert H, Corte GAS, A (2001). OTD/OTX2 functional equivalence depends on 5’ and 3’ UTR-mediated control of otx2 mRNA for nucleo-cytoplasmic export and epiblast restricted translation.. Development, 128, 4801 - 4813.
    • Acampora D, Pilo Boyl P, Martinez-Barbera JP, Annino A, Signore MAS, A (2001). Otx genes in evolution: are they involved in instructing the vertebrate brain morphology?. Journal of Anatomy, 199, 53 - 62.
    • Martinez-Barbera JP, Signore M, Boyl PP, Puelles E, Acampora D, Gogoi R, Schubert F, Lumsden A, Simeone A (2001). Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.. Development, 128(23), 4789 - 4800.
    • Dasen JS, Martinez-Barbera JP, Herman TS, Connell SO, Olson L, Ju B, Tollkuhn J, Buek SH, Rose DW, Rosenfeld MG (2001). Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes and Development, 15(23), 3193 - 3207. doi:10.1101/gad.932601

    2000

    • Martinez-Barbera JP, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D, Beddington RS (2000). The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.. Development, 127, 2433 - 2445.
    • Martinez-Barbera JP, Rodriguez TAABRS (2000). The homeobox gene Hesx1 is required in the anterior neural ectoderm for normal forebrain formation. Developmental Biology, 223, 422 - 430.
    • Dattani ML, Martinez-Barbera JP, Thomas PQ, Brickman JM, Gupta R, Wales JK, Hindmarsh PC, Beddington RS, Robinson IC (2000). Molecular genetics of septo-optic dysplasia.. Hormone Research, 53(26), 33 - .

    1999

    • Dattani MT, Martinez-Barbera JP, Thomas PQ, Brickman JM, Gupta R, Wales JK, Hindmarsh PC, Beddington RS, Robinson IC (1999). HESX1: a novel gene implicated in a familial form of septo-optic dysplasia. Acta Paediatr Suppl, 88(433), 49 - 54.

    1998

    • Dattani MT, Martinez-Barbera JP, Thomas PQ, Brickman JM, Gupta R, Martensson IL, Toresson H, Fox M, Wales JK, Hindmarsh PC, Krauss S, Beddington RS, Robinson IC (1998). Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet, 19(2), 125 - 133. doi:10.1038/477
    • Toresson H, Martinez-Barbera JP1, Bardsley A, Caubit XAK, S (1998). Conservation of BF1 expression in amphioxus and zebrafish suggests evolutionary ancestry of anterior cell types that contribute to the vertebrate telencephalon. Development, Genes and Evolution, 208, 431 - 439.
    • Nornes S, Clarkson M, Mikkola I, Pedersen M, Bardsley A, Martinez-Barbera JP, Krauss SAJ, T (1998). Zebrafish contains two Pax6 genes involved in eye development. Mechanisms of Development, 77, 185 - 196.

    1997

    • Martinez-Barbera JP, Toresson H, Da Rocha SAK, S (1997). Cloning and expression of three members of the zebrafish bmp family: Bmp2a, Bmp2b and Bmp4.. Gene, 198, 53 - 59.
    • Martinez-Barbera JP, Vila V, Valdivia MM, Castrillo JL (1997). Molecular Cloning of gilthead seabream (Sparus aurata) pituitary transcription factor GHF-1/Pit-1.. Gene, 185(1), 87 - 93.

    1996

    • Pendon C, Martinez-Barbera JP, Ortiz MAV, M M (1996). Bacterial production and purification of the fish pituitary hormone somatolactin.. Protein Expression and Purification, 7, 389 - 394.
    • Muñoz-Cueto JA, Martinez-Barbera JP, Pendon C, Rodriguez RBAS, M C (1996). Autoradiographic localization of growth hormone binding sites in Sparus aurata tissues using a recombinant gilhead seabream growth hormone. Comparative Biochemistry and Physiology, 114, 17 - 22. doi:10.1016/0742-8413(96)00005-9
    • Marti-Palanca H, Martinez-Barbera JP, Pendon C, Valdivia MM, Perez-Sánchez JAK, S (1996). Growth hormone as a function of age and dietary protein: Energy ratio in a marine teleost, the gilthead sea bream (Sparus aurata).. Growth Regulation, 6, 253 - 259.

    1995

    • Vila V, Jimenez O, Güell A, Vallejo D, De La Hoya M, Burgos A, Etxabe J, Martinez-Barbera JP, and Castrillo JL (1995). The pituitary transcription factor GHF-1/Pit-1: An evolutionary overview.. Netherland Journal of Zoology, 45, 229 - 234. doi:10.1163/156854295X00997
    • Martinez-Barbera JP, Pendon C, Martin-Palanca H, Calduch-Giner JA, Rodriguez RB, Valdivia MMAP-S, J (1995). The use of recombinant gilthead sea bream (Sparus aurata) growth hormone for radioiodination and standard preparation in radioimmunoassay.. Comparative Biochemistry and Physiology, 110, 335 - 340.

    1994

    • Pendon C, Martinez-Barbera JP, Valdivia MM (1994). Cloning of a somatolactin-encoding cDNA from Solea senegalensis. Gene, 147, 227 - 230.
    • Martínez-Barberá JP, Pendón C, Rodríguez RB, Pérez-Sánchez J, Valdivia MM (1994). Cloning, expression, and characterization of a recombinant gilthead seabream growth hormone.. Gen Comp Endocrinol, 96(2), 179 - 188. doi:10.1006/gcen.1994.1172
    • Pendon C, Martinez-Barbera JP, Perez Sanchez J, Rodriguez RB, Grenett H, Valdivia MM (1994). Cloning of the sole (Solea senegalensis) growth hormone-encoding cDNA. Gene, 145(2), 237 - 240. doi:10.1016/0378-1119(94)90012-4