Prof Juan Casas Romero


Personal Profile

Name: Juan Casas Romero Email:
Title: Prof Tel:
Department: Institute of Cardiovascular Science Fax:
Position: Professor of Cardiovascular Epidemiology Address: , , ,
Research Domain: Cardiometabolic Science, Genetics (Frontier Disciplines), Global Health, Personalised Medicine, Populations & Lifelong Health, Reproduction & Development Web Page:  


Research Description

My major interest is in the application of the Mendelian randomisation principles  to identify causal factors  in cardiovascular disease and pre-eclampsia. More recently, I am interested in the use of genetics to select and validate therapeutic targets.  For this, I make use of large-scale observational studies that I have established or being involved in the last years, those include:

The UCLEB consortium: A group of cohorts from UCL, LSHTM, Edinburgh and Bristol in which we are currently conducting large-scale genotyping using the Metabochip. Work funded by the British Heart Foundation.  

The GenPE study: a large case-control study in pre-eclampsia. This study has recruited over 3700 cases and 4777 controls and 2800 umbilical cord samples, this  study is still ongoing, for details please see I have recently completed a genome-wide association study in Pre-eclampsia, under the umbrella of the WTCCC2. 

British Women Heart & Health Study: From April 2009 I am working as co-Director of the British Women's Heart & Health Study a cohort of over 4000 women in 23 British towns, resource use to investigate the causes and a consequence of cardiovascular disease.

Cardiovascular disease Latin-America: In collaboration with Dr. Bautista at Wisconsin university, we have established a large consortium of population-based studies from Latin America to evaluate the impact of obesity and cardiovascular disease in the region (

Research Activities

Education Description

During my time at LSHTM, I have participated in teaching activities that teaching has span from extended epidemiology, design and analyses of epidemiological studies, study design to genetic epidemiology. During the last five years, I also co-organize the non-communicable disease epidemioloy unit.

UCL Collaborators

External Collaborators



    • Meier P, Ebrahim S, Otto CM, Casas JP (2013). Oxygen therapy in acute myocardial infarction – good or bad?. Cochrane Database Syst Rev, 8, ED000065 - . doi:10.1002/14651858.ED000065
    • Gaunt TR, Zabaneh D, Shah S, Guyatt A, Ladroue C, Kumari M, Drenos F, Shah T, Talmud PJ, Casas JP, Lowe G, Rumley A, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Humphries SE, Day IN (2013). Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip.. Thromb Haemost, 110(5), 995 - 1003. doi:10.1160/TH13-02-0087
    • Harrison SC, Smith AJ, Jones GT, Swerdlow DI, Rampuri R, Bown MJ, Aneurysm Consortium , Folkersen L, Baas AF, de Borst GJ, Blankensteijn JD, Price JF, van der Graaf Y, McLachlan S, Agu O, Hofman A, Uitterlinden AG, Franco-Cereceda A, Ruigrok YM, van't Hof FN, Powell JT, van Rij AM, Casas JP, Eriksson P, Holmes MV, Asselbergs FW, Hingorani AD, Humphries SE (2013). Interleukin-6 receptor pathways in abdominal aortic aneurysm.. Eur Heart J, 34(48), 3707 - 3716. doi:10.1093/eurheartj/ehs354
    • Shah S, Casas JP, Gaunt TR, Cooper J, Drenos F, Zabaneh D, Swerdlow DI, Shah T, Sofat R, Palmen J, Kumari M, Kivimaki M, Ebrahim S, Smith GD, Lawlor DA, Talmud PJ, Whittaker J, Day IN, Hingorani AD, Humphries SE (2013). Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.. Eur Heart J, 34(13), 972 - 981. doi:10.1093/eurheartj/ehs243
    • Choi M, Prieto-Merino D, Dale C, Nüesch E, Amuzu A, Bowling A, Ebrahim S, Casas JP (2013). Effect of changes in moderate or vigorous physical activity on changes in health-related quality of life of elderly British women over seven years.. Qual Life Res, 22(8), 2011 - 2020. doi:10.1007/s11136-012-0332-2
    • LeishGEN Consortium , Wellcome Trust Case Control Consortium 2 , Fakiola M, Strange A, Cordell HJ, Miller EN, Pirinen M, Su Z, Mishra A, Mehrotra S, Monteiro GR, Band G, Bellenguez C, Dronov S, Edkins S, Freeman C, Giannoulatou E, Gray E, Hunt SE, Lacerda HG, Langford C, Pearson R, Pontes NN, Rai M, Singh SP, Smith L, Sousa O, Vukcevic D, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Wilson ME, Deloukas P, Peltonen L, Christiansen F, Witt C, Jeronimo SM, Sundar S, Spencer CC, Blackwell JM, Donnelly P (2013). Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.. Nat Genet, 45(2), 208 - 213. doi:10.1038/ng.2518
    • Bautista LE, Vera-Cala LM, Ferrante D, Herrera VM, Miranda JJ, Pichardo R, Sánchez Abanto JR, Ferreccio C, Silva E, Oróstegui Arenas M, Chirinos JA, Medina-Lezama J, Pérez CM, Schapochnik N, Casas JP (2013). A 'polypill' aimed at preventing cardiovascular disease could prove highly cost-effective for use in Latin America.. Health Aff (Millwood), 32(1), 155 - 164. doi:10.1377/hlthaff.2011.0948
    • Gaunt TR, Lowe GD, Lawlor DA, Casas JP, Day IN (2013). A gene-centric analysis of activated partial thromboplastin time and activated protein C resistance using the HumanCVD focused genotyping array.. Eur J Hum Genet, 21(7), 779 - 783. doi:10.1038/ejhg.2012.242
    • Miranda JJ, Herrera VM, Chirinos JA, Gómez LF, Perel P, Pichardo R, González A, Sánchez JR, Ferreccio C, Aguilera X, Silva E, Oróstegui M, Medina-Lezama J, Pérez CM, Suárez E, Ortiz AP, Rosero L, Schapochnik N, Ortiz Z, Ferrante D, Casas JP, Bautista LE (2013). Major cardiovascular risk factors in Latin America: a comparison with the United States. The Latin American Consortium of Studies in Obesity (LASO).. PLoS One, 8(1), e54056 - . doi:10.1371/journal.pone.0054056
    • Ebrahim S, Pearce N, Smeeth L, Casas JP, Jaffar S, Piot P (2013). Tackling non-communicable diseases in low- and middle-income countries: is the evidence from high-income countries all we need?. PLoS Med, 10(1), e1001377 - . doi:10.1371/journal.pmed.1001377
    • Bodalia PN, Grosso AM, Sofat R, Macallister RJ, Smeeth L, Dhillon S, Casas JP, Wonderling D, Hingorani AD (2013). Comparative efficacy and tolerability of anti-epileptic drugs for refractory focal epilepsy: systematic review and network meta-analysis reveals the need for long term comparator trials.. Br J Clin Pharmacol, 76(5), 649 - 667. doi:10.1111/bcp.12083
    • Dale CE, Bowling A, Adamson J, Kuper H, Amuzu A, Ebrahim S, Casas JP, Nüesch E (2013). Predictors of patterns of change in health-related quality of life in older women over 7 years: evidence from a prospective cohort study.. Age Ageing, 42(3), 312 - 318. doi:10.1093/ageing/aft029
    • Leon DA, Shkolnikov VM, Borinskaya S, Casas JP, Evans A, Gil A, Kee F, Kiryanov N, McKee M, O'Doherty MG, Ploubidis GB, Polikina O, Vassiliev M, Blankenberg S, Watkins H (2013). Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies.. Eur J Epidemiol, 28(5), 393 - 404. doi:10.1007/s10654-013-9808-9
    • Ripke S Fau - O'Dushlaine C, O'Dushlaine C Fau - Chambert K, Chambert K Fau - Moran JL, Moran Jl Fau - Kahler AK, Kahler Ak Fau - Akterin S, Akterin S Fau - Bergen SE, Bergen Se Fau - Collins AL, Collins Al Fau - Crowley JJ, Crowley Jj Fau - Fromer M, Fromer M Fau - Kim Y, Kim Y Fau - Lee SH, Lee Sh Fau - Magnusson PKE, Magnusson Pk Fau - Sanchez N, Sanchez N Fau - Stahl EA, Stahl Ea Fau - Williams S, Williams S Fau - Wray NR, Wray Nr Fau - Xia K, Xia K Fau - Bettella F, Bettella F Fau - Borglum AD, Borglum Ad Fau - Bulik-Sullivan BK, Bulik-Sullivan Bk Fau - Cormican P, Cormican P Fau - Craddock N, Craddock N Fau - de Leeuw C, de Leeuw C Fau - Durmishi N, Durmishi N Fau - Gill M, Gill M Fau - Golimbet V, Golimbet V Fau - Hamshere ML, Hamshere Ml Fau - Holmans P, Holmans P Fau - Hougaard DM, Hougaard Dm Fau - Kendler KS, Kendler Ks Fau - Lin K, Lin K Fau - Morris DW, Morris Dw Fau - Mors O, Mors O Fau - Mortensen PB, Mortensen Pb Fau - Neale BM, Neale Bm Fau - O'Neill FA, O'Neill Fa Fau - Owen MJ, Owen Mj Fau - Milovancevic MP, Milovancevic Mp Fau - Posthuma D, Posthuma D Fau - Powell J, Powell J Fau - Richards AL, Richards Al Fau - Riley BP, Riley Bp Fau - Ruderfer D, Ruderfer D Fau - Rujescu D, Rujescu D Fau - Sigurdsson E, Sigurdsson E Fau - Silagadze T, Silagadze T Fau - Smit AB, Smit Ab Fau - Stefansson H, Stefansson H Fau - Steinberg S, Steinberg S Fau - Suvisaari J, Suvisaari J Fau - Tosato S, Tosato S Fau - Verhage M, Verhage M Fau - Walters JT, Walters JT, Levinson Df Fau - Gejman PV, Gejman Pv Fau - Kendler KS, Kendler Ks Fau - Laurent C, Laurent C Fau - Mowry BJ, Mowry Bj Fau - O'Donovan MC, O'Donovan Mc Fau - Owen MJ, Owen Mj Fau - Pulver AE, Pulver Ae Fau - Riley BP, Riley Bp Fau - Schwab SG, Schwab Sg Fau - Wildenauer DB, Wildenauer Db Fau - Dudbridge F, Dudbridge F Fau - Holmans P, Holmans P Fau - Shi J, Shi J Fau - Albus M, Albus M Fau - Alexander M, Alexander M Fau - Campion D, Campion D Fau - Cohen D, Cohen D Fau - Dikeos D, Dikeos D Fau - Duan J, Duan J Fau - Eichhammer P, Eichhammer P Fau - Godard S, Godard S Fau - Hansen M, Hansen M Fau - Lerer FB, Lerer Fb Fau - Liang K, Liang Ky Fau - Maier W, Maier W Fau - Mallet J, Mallet J Fau - Nertney DA, Nertney Da Fau - Nestadt G, Nestadt G Fau - Norton N, Norton N Fau - O'Neill FA, O'Neill Fa Fau - Papadimitriou GN, Papadimitriou Gn Fau - Ribble R, Ribble R Fau - Sanders AR, Sanders Ar Fau - Silverman JM, Silverman Jm Fau - Walsh D, Walsh D Fau - Williams NM, Williams Nm Fau - Wormley B, Wormley B, Arranz Mj Fau - Bakker S, Bakker S Fau - Bender S, Bender S Fau - Bramon E, Bramon E Fau - Collier D, Collier D Fau - Crespo-Facorro B, Crespo-Facorro B Fau - Hall J, Hall J Fau - Iyegbe C, Iyegbe C Fau - Jablensky A (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia.. Nature Genetics, Ahead of Publication, - .
    • Sánchez-Santos MT, Mesa-Frias M, Choi M, Nüesch E, Asunsolo-Del Barco A, Amuzu A, Smith GD, Ebrahim S, Prieto-Merino D, Casas JP (2013). Area-level deprivation and overall and cause-specific mortality: 12 years' observation on British women and systematic review of prospective studies.. PLoS One, 8(9), e72656 - . doi:10.1371/journal.pone.0072656
    • Timmis A, Meier P, Ebrahim S, Casas JP, Otto C (2013). Heart and the Cochrane Collaboration.. Heart, 99(19), 1379 - 1380. doi:10.1136/heartjnl-2013-304475
    • Meier P, Timmis A, Casas JP, Otto C (2013). Cochrane Corner: is there a benefit of using intracoronary vasodilators in ST segment elevation myocardial infarction?. Heart, 99(19), 1381 - 1382. doi:10.1136/heartjnl-2013-304476
    • Shah T, Engmann J, Finan C, Holmes MV, Kumari M, Kivimaki M, Casas JP, Hingorani AD, Dale C, Amuzu A, Warren H, Ebrahim S, Dudbridge F, Shah S, White J, Giambartolomei C, Zabaneh D, Plagnol V, McLachlan S, Price J, Cavadino A, Power C, Hypponen E, Wong A, Ong K, Richards M, Hardy R, Kuh D, Wareham N, Gaunt T, Davies T-L, Lawlor DA, Day IN, Drenos F, Cooper J, Talmud PJ, Humphries SE, Sofat R, Caulfield M, Ben-Shlomo Y, Whincup P, Morris R, Strachan MWJ, Whittaker JC (2013). Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS ONE, 8(8), - . doi:10.1371/journal.pone.0071345
    • Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EP, Li M, Leusink M, Trompet S, Verschuren JJ, Hovingh GK, Dehghan A, Nelson CP, Kotti S, Danchin N, Scholz M, Haase CL, Rothenbacher D, Swerdlow DI, Kuchenbaecker KB, Staines-Urias E, Goel A, van 't Hooft F, Gertow K, de Faire U, Panayiotou AG, Tremoli E, Baldassarre D, Veglia F, Holdt LM, Beutner F, Gansevoort RT, Navis GJ, Mateo Leach I, Breitling LP, Brenner H, Thiery J, Dallmeier D, Franco-Cereceda A, Boer JM, Stephens JW, Hofker MH, Tedgui A, Hofman A, Uitterlinden AG, Adamkova V, Pitha J, Onland-Moret NC, Cramer MJ, Nathoe HM, Spiering W, Klungel OH, Kumari M, Whincup PH, Morrow DA, Braund PS, Hall AS, Olsson AG, Doevendans PA, Trip MD, Tobin MD, Hamsten A, Watkins H, Koenig W, Nicolaides AN, Teupser D, Day IN, Carlquist JF, Gaunt TR, Ford I, Sattar N, Tsimikas S, Schwartz GG, Lawlor DA, Morris RW, Sandhu MS, Poledne R, Maitland-van der Zee AH, Khaw KT, Keating BJ, van der Harst P, Price JF, Mehta SR, Yusuf S, Witteman JC, Franco OH, Jukema JW, de Knijff P, Tybjaerg-Hansen A, Rader DJ, Farrall M, Samani NJ, Kivimaki M, Fox KA, Humphries SE, Anderson JL, Boekholdt SM, Palmer TM, Eriksson P, Paré G, Hingorani AD, Sabatine MS, Mallat Z, Casas JP, Talmud PJ (2013). Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.. J Am Coll Cardiol, 62(21), 1966 - 1976. doi:10.1016/j.jacc.2013.06.044
    • Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, Cooper J, Talmud PJ, Humphries SE, Sundstrom J, Hubacek JA, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Abdollahi MR, Slooter AJ, Szolnoki Z, Sandhu M, Wareham N, Frikke-Schmidt R, Tybjærg-Hansen A, Fillenbaum G, Heijmans BT, Katsuya T, Gromadzka G, Singleton A, Ferrucci L, Hardy J, Worrall B, Rich SS, Matarin M, Whittaker J, Gaunt TR, Whincup P, Morris R, Deanfield J, Donald A, Davey Smith G, Kivimaki M, Kumari M, Smeeth L, Khaw KT, Nalls M, Meschia J, Sun K, Hui R, Day I, Hingorani AD, Casas JP (2013). Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.. Int J Epidemiol, 42(2), 475 - 492. doi:10.1093/ije/dyt034
    • Shah T, Zabaneh D, Gaunt T, Swerdlow DI, Shah S, Talmud PJ, Day IN, Whittaker J, Holmes MV, Sofat R, Humphries SE, Kivimaki M, Kumari M, Hingorani AD, Casas JP (2013). Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.. Circ Cardiovasc Genet, 6(2), 163 - 170. doi:10.1161/CIRCGENETICS.112.964254
    • Shah S, Casas JP, Drenos F, Whittaker J, Deanfield J, Swerdlow DI, Holmes MV, Kivimaki M, Langenberg C, Wareham N, Gertow K, Sennblad B, Strawbridge RJ, Baldassarre D, Veglia F, Tremoli E, Gigante B, de Faire U, Kumari M, Talmud PJ, Hamsten A, Humphries SE, Hingorani AD (2013). Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis.. Circ Cardiovasc Genet, 6(1), 63 - 72. doi:10.1161/CIRCGENETICS.112.963140


    • Staines-Urias E, Paez MC, Doyle P, Dudbridge F, Serrano NC, Ioannidis JP, Keating BJ, Hingorani AD, Casas JP (2012). Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis.. Int J Epidemiol, 41(6), 1764 - 1775. doi:10.1093/ije/dys162
    • Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-DeHoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM, Look AHEAD Research Group , DIAGRAM consortium , Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Sever P, Poulter N, Caulfield M, Dominiczak A, Shields DC, Bhatt DL, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW, Farrall M, FitzGerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs FW, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ (2012). Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.. Am J Hum Genet, 90(3), 410 - 425. doi:10.1016/j.ajhg.2011.12.022
    • Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J, Palmen J, Tzoulaki I, Wong A, Jefferis BJ, Maniatis N, Drenos F, Gigante B, Hardy R, Laxton RC, Leander K, Motterle A, Simpson IA, Smeeth L, Thomson A, Verzilli C, Kuh D, Ireland H, Deanfield J, Caulfield M, Wallace C, Samani N, Munroe PB, Lathrop M, Fowkes FG, Marmot M, Whincup PH, Whittaker JC, de Faire U, Kivimaki M, Kumari M, Hypponen E, Power C, Humphries SE, Talmud PJ, Price J, Morris RW, Ye S, Casas JP, Hingorani AD (2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.. Eur Heart J, 33(3), 393 - 407. doi:10.1093/eurheartj/ehr225
    • Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium (2012). The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.. Lancet, 379(9822), 1214 - 1224. doi:10.1016/S0140-6736(12)60110-X
    • Ebrahim S, Casas JP (2012). Statins for all by the age of 50 years?. Lancet, 380(9841), 545 - 547. doi:10.1016/S0140-6736(12)60694-1
    • Hingorani AD, Sofat R, Morris RW, Whincup P, Lowe GD, Mindell J, Sattar N, Casas JP, Shah T (2012). Is it important to measure or reduce C-reactive protein in people at risk of cardiovascular disease?. Eur Heart J, 33(18), 2258 - 2264. doi:10.1093/eurheartj/ehs168
    • Gaunt TR, Shah S, Nelson CP, Drenos F, Braund PS, Adeniran I, Folkersen L, Lawlor DA, Casas JP, Amuzu A, Kivimaki M, Whittaker J, Eriksson P, Zhang H, Hancox JC, Tomaszewski M, Burton PR, Tobin MD, Humphries SE, Talmud PJ, Macfarlane PW, Hingorani AD, Samani NJ, Kumari M, Day IN (2012). Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip.. Circ Cardiovasc Genet, 5(6), 630 - 638. doi:10.1161/CIRCGENETICS.112.962852
    • Nüesch E, Dale CE, Amuzu A, Kuper H, Bowling A, Ploubidis GB, Lowe G, Rumley A, Ebrahim S, Casas JP (2012). Inflammation, coagulation and risk of locomotor disability in elderly women: findings from the British Women's Heart and Health Study.. Eur J Epidemiol, 27(8), 633 - 645. doi:10.1007/s10654-012-9706-6
    • Holmes MV, Hingorani AD, Casas JP (2012). CYP2C19 Genotype and Cardiovascular Events Reply. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 307(14), 1484 - 1485. doi:10.1001/jama.2012.446
    • Sofat R, Casas JP, Grosso AM, Prichard BNC, Smeeth L, MacAllister R, Hingorani AD (2012). Could NICE guidance on the choice of blood pressure lowering drugs be simplified?. BRITISH MEDICAL JOURNAL, 344, - . doi:10.1136/bmj.d8078
    • Sofat R, Casas JP, Webster AR, Bird AC, Mann SS, Yates JR, Moore AT, Sepp T, Cipriani V, Bunce C, Khan JC, Shahid H, Swaroop A, Abecasis G, Branham KE, Zareparsi S, Bergen AA, Klaver CC, Baas DC, Zhang K, Chen Y, Gibbs D, Weber BH, Keilhauer CN, Fritsche LG, Lotery A, Cree AJ, Griffiths HL, Bhattacharya SS, Chen LL, Jenkins SA, Peto T, Lathrop M, Leveillard T, Gorin MB, Weeks DE, Ortube MC, Ferrell RE, Jakobsdottir J, Conley YP, Rahu M, Seland JH, Soubrane G, Topouzis F, Vioque J, Tomazzoli L, Young I, Whittaker J, Chakravarthy U, de Jong PT, Smeeth L, Fletcher A, Hingorani AD (2012). Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype.. Int J Epidemiol, 41(1), 250 - 262. doi:10.1093/ije/dyr204
    • International Stroke Genetics Consortium (ISGC) , Wellcome Trust Case Control Consortium 2 (WTCCC2) , Bellenguez C, Bevan S, Gschwendtner A, Spencer CC, Burgess AI, Pirinen M, Jackson CA, Traylor M, Strange A, Su Z, Band G, Syme PD, Malik R, Pera J, Norrving B, Lemmens R, Freeman C, Schanz R, James T, Poole D, Murphy L, Segal H, Cortellini L, Cheng YC, Woo D, Nalls MA, Müller-Myhsok B, Meisinger C, Seedorf U, Ross-Adams H, Boonen S, Wloch-Kopec D, Valant V, Slark J, Furie K, Delavaran H, Langford C, Deloukas P, Edkins S, Hunt S, Gray E, Dronov S, Peltonen L, Gretarsdottir S, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Boncoraglio GB, Parati EA, Attia J, Holliday E, Levi C, Franzosi MG, Goel A, Helgadottir A, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Worrall BB, Kittner SJ, Mitchell BD, Kissela B, Meschia JF, Thijs V, Lindgren A, Macleod MJ, Slowik A, Walters M, Rosand J, Sharma P, Farrall M, Sudlow CL, Rothwell PM, Dichgans M, Donnelly P, Markus HS (2012). Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.. Nat Genet, 44(3), 328 - 333. doi:10.1038/ng.1081
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    • Wensley F, Gao P, Burgess S, Kaptoge S, Di Angelantonio E, Shah T, Engert JC, Clarke R, Davey-Smith G, Nordestgaard BG, Saleheen D, Samani NJ, Sandhu M, Anand S, Pepys MB, Smeeth L, Whittaker J, Casas JP, Thompson SG, Hingorani AD, Danesh J (2011). Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ, 342, d548 - . doi:10.1136/bmj.d548
    • Zabaneh D, Kumari M, Sandhu M, Wareham N, Wainwright N, Papamarkou T, Hopewell J, Clarke R, Li K, Palmen J, Talmud PJ, Kronenberg F, Lamina C, Summerer M, Paulweber B, Price J, Fowkes G, Stewart M, Drenos F, Shah S, Shah T, Casas JP, Kivimaki M, Whittaker J, Hingorani AD, Humphries SE (2011). Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts. Atherosclerosis, 217, 447 - 451.


    • Casas JP, Ninio E, Panayiotou A, Palmen J, Cooper JA, Ricketts SL, Sofat R, Nicolaides AN, Corsetti JP, Fowkes FG, Tzoulaki I, Kumari M, Brunner EJ, Kivimaki M, Marmot MG, Hoffmann MM, Winkler K, März W, Ye S, Stirnadel HA, Boekholdt SM, Khaw KT, Humphries SE, Sandhu MS, Hingorani AD, Talmud PJ (2010). PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.. Circulation, 121(21), 2284 - 2293. doi:10.1161/CIRCULATIONAHA.109.923383
    • Serrano NC, Díaz LA, Casas JP, Hingorani AD, Moreno de Lucca D, Páez MC (2010). Frequency of eNOS polymorphisms in the Colombian general population.. BMC Genet, 11, 54 - . doi:10.1186/1471-2156-11-54
    • Strange A, Capon F, Spencer CCA, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JGM, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Huffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WHI, McManus R, Mossner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CNA, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Stahle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PLJM, Hayday A, Burden AD, Griffiths CEM, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC, Genetic Anal Psoriasis Consortium , Wellcome Trust Case Control (2010). A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. NAT GENET, 42(11), 985 - U106. doi:10.1038/ng.694
    • Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, Shah T, Sandhu MS, Ricketts SL, Boekholdt SM, Wareham N, Khaw KT, Kumari M, Kivimaki M, Marmot M, Asselbergs FW, van der Harst P, Dullaart RP, Navis G, van Veldhuisen DJ, Van Gilst WH, Thompson JF, McCaskie P, Palmer LJ, Arca M, Quagliarini F, Gaudio C, Cambien F, Nicaud V, Poirer O, Gudnason V, Isaacs A, Witteman JC, van Duijn CM, Pencina M, Vasan RS, D'Agostino RB, Ordovas J, Li TY, Kakko S, Kauma H, Savolainen MJ, Kesaniemi YA, Sandhofer A, Paulweber B, Sorli JV, Goto A, Yokoyama S, Okumura K, Horne BD, Packard C, Freeman D, Ford I, Sattar N, McCormack V, Lawlor DA, Ebrahim S, Smith GD, Kastelein JJ, Deanfield J, Casas JP (2010). Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation, 121, 52 - 62.
    • Casas JP, Kwong J, Ebrahim S (2010). Telemonitoring for chronic heart failure: not ready for prime time. Cochrane Database Syst Rev, 8, ED000008 - .
    • Shah T, Newcombe P, Smeeth L, Addo J, Casas JP, Whittaker J, Miller MA, Tinworth L, Jeffery S, Strazzullo P, Cappuccio FP, Hingorani AD (2010). Ancestry as a determinant of mean population C-reactive protein values: implications for cardiovascular risk prediction. Circ Cardiovasc Genet, 3, 436 - 444.
    • Sofat R, Casas JP, Kumari M, Talmud PJ, Ireland H, Kivimaki M, Marmot M, Hughes AD, Thom S, Ebrahim S, Whittaker JC, Smeeth L, Lawlor DA, Humphries SE, Hingorani AD (2010). Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals. Atherosclerosis, 213, 184 - 190.
    • Burgess S, Thompson SG, Andrews G, Samani NJ, Hall A, Whincup P, Morris R, Lawlor DA, Davey Smith G, Timpson N, Ebrahim S, Ben-Shlomo Y, Brown M, Ricketts S, Sandhu M, Reiner A, Psaty B, Lange L, Cushman M, Hung J, Thompson P, Beilby J, Warrington N, Palmer LJ, Nordestgaard BG, Tybjaerg-Hansen A, Zacho J, Wu C, Lowe G, Tzoulaki I, Kumari M, Yamamoto JF, Chiodini B, Franzosi M, Hankey GJ, Jamrozik K, Palmer L, Rimm E, Pai J, Heckbert S, Bis J, Anand S, Engert J, Collins R, Clarke R, Melander O, Berglund G, Ladenvall P, Johansson L, Jansson JH, Hallmans G, Hingorani A, Humphries S, Manson J, Watkins H, Hopewell J, Saleheen D, Frossard R, Danesh J, Sattar N, Robertson M, Shepherd J, Schaefer E, Hofman A, Witteman JC, Kardys I, de Faire U, Bennet A, Ford I, Packard C, Casas JP, Smeeth L, Wensley F, Bowden J, Di Angelantonio E, Gao P, Shah T, Verzilli C, Walker M, Whittaker J (2010). Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Stat Med, 29, 1298 - 1311.


    • Holmes MV, Shah T, Vickery C, Smeeth L, Hingorani AD, Casas JP (2009). Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.. PLoS One, 4(12), e7960 - . doi:10.1371/journal.pone.0007960
    • Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Bellenguez C, Davison D, Freeman C, Strange A, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Attwood AP, Stephens J, Sambrook J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP (2009). Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet, 41, 1330 - 1334.
    • Bautista LE, Casas JP, Herrera VM, Miranda JJ, Perel P, Pichardo R, Gonzalez A, Sanchez JR, Ferreccio C, Aguilera X, Silva E, Orostegui M, Gomez LF, Chirinos JA, Medina-Lezama J, Perez CM, Suarez E, Ortiz AP, Rosero L, Schapochnik N, Ortiz Z, Ferrante D (2009). The Latin American Consortium of Studies in Obesity (LASO). Obes Rev, 10, 364 - 370.
    • Bellamy L, Casas JP, Hingorani AD, Williams D (2009). Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet, 373, 1773 - 1779.
    • Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD (2009). Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. Hum Mol Genet, 18, 2305 - 2316.
    • Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet, 85, 628 - 642.
    • Hingorani AD, Shah T, Casas JP, Humphries SE, Talmud PJ (2009). C-reactive protein and coronary heart disease: predictive test or therapeutic target?. Clin Chem, 55, 239 - 255.
    • Newcombe PJ, Verzilli C, Casas JP, Hingorani AD, Smeeth L, Whittaker JC (2009). Multilocus Bayesian meta-analysis of gene-disease associations. Am J Hum Genet, 84, 567 - 580.
    • Rao R, Tah V, Casas JP, Hingorani A, Whittaker J, Smeeth L, Sharma P (2009). Ischaemic stroke subtypes and their genetic basis: a comprehensive meta-analysis of small and large vessel stroke. Eur Neurol, 61, 76 - 86.
    • Shah T, Casas JP, Cooper JA, Tzoulaki I, Sofat R, McCormack V, Smeeth L, Deanfield JE, Lowe GD, Rumley A, Fowkes FG, Humphries SE, Hingorani AD (2009). Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts. Int J Epidemiol, 38, 217 - 231.
    • Herrera VM, Casas JP, Miranda JJ, Perel P, Pichardo R, Gonzalez A, Sanchez JR, Ferreccio C, Aguilera X, Silva E, Orostegui M, Gomez LF, Chirinos JA, Medina-Lezama J, Perez CM, Suarez E, Ortiz AP, Rosero L, Schapochnik N, Ortiz Z, Ferrante D, Diaz M, Bautista LE (2009). Interethnic differences in the accuracy of anthropometric indicators of obesity in screening for high risk of coronary heart disease. Int J Obes (Lond), 33, 568 - 576.


    • CRP CGC (2008). Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation. European Journal of Epidemiology, 23(8), 531 - 540. doi:10.1007/s10654-008-9249-z
    • Brunner EJ, Kivimaki M, Witte DR, Lawlor DA, Davey Smith G, Cooper JA, Miller M, Lowe GD, Rumley A, Casas JP, Shah T, Humphries SE, Hingorani AD, Marmot MG, Timpson NJ, Kumari M (2008). Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. PLoS Med, 5, e155 - .
    • Casas JP (2008). Commentary: Social class, C-reactive protein and coronary heart disease. Int J Epidemiol, 37, 299 - 300.
    • Casas JP, Shah T, Hingorani AD, Danesh J, Pepys MB (2008). C-reactive protein and coronary heart disease: a critical review. J Intern Med, 264, 295 - 314.
    • Verzilli C, Shah T, Casas JP, Chapman J, Sandhu M, Debenham SL, Boekholdt MS, Khaw KT, Wareham NJ, Judson R, Benjamin EJ, Kathiresan S, Larson MG, Rong J, Sofat R, Humphries SE, Smeeth L, Cavalleri G, Whittaker JC, Hingorani AD (2008). Bayesian meta-analysis of genetic association studies with different sets of markers. Am J Hum Genet, 82, 859 - 872.
    • Kivimaki M, Lawlor DA, Smith GD, Kumari M, Donald A, Britton A, Casas JP, Shah T, Brunner E, Timpson NJ, Halcox JP, Miller MA, Humphries SE, Deanfield J, Marmot MG, Hingorani AD (2008). Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. PLoS One, 3(8), - . doi:10.1371/journal.pone.0003013
    • Miranda JJ, Kinra S, Casas JP, Davey Smith G, Ebrahim S (2008). Non-communicable diseases in low- and middle-income countries: context, determinants and health policy. Trop Med Int Health, 13, 1225 - 1234.
    • Peck G, Smeeth L, Whittaker J, Casas JP, Hingorani A, Sharma P (2008). The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults. PLoS One, 3, e3691 - .
    • Perel P, Miranda JJ, Ortiz Z, Casas JP (2008). Relation between the global burden of disease and randomized clinical trials conducted in Latin America published in the five leading medical journals. PLoS One, 3, e1696 - .
    • Clarke R, Emberson JR, Breeze E, Casas JP, Parish S, Hingorani AD, Fletcher A, Collins R, Smeeth L (2008). Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. Eur Heart J, 29, 800 - 809.


    • Ariyaratnam R, Casas JP, Whittaker J, Smeeth L, Hingorani AD, Sharma P (2007). Genetics of ischaemic stroke among persons of non-European descent: a meta-analysis of eight genes involving approximately 32,500 individuals. PLoS Med, 4, e131 - .
    • Bellamy L, Casas JP, Hingorani AD, Williams DJ (2007). Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ, 335, 974 - .
    • Smeeth L, Casas JP, Hingorani AD (2007). The role of infection in cardiovascular disease: more support but many questions remain. Eur Heart J, 28, 1178 - 1179.
    • Seminara D, Khoury MJ, O'Brien TR, Manolio T, Gwinn ML, Little J, Higgins JP, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam AP, Danesh J, Davey Smith G, Dolan S, Duncan R, Gruis NA, Hashibe M, Hunter D, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, Riboli E, Salanti G, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Ioannidis JP (2007). The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology, 18, 1 - 8.
    • Mayahi L, Heales S, Owen D, Casas JP, Harris J, MacAllister RJ, Hingorani AD (2007). (6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm. Arterioscler Thromb Vasc Biol, 27, 1334 - 1339.


    • Casas JP, Vallance P, Smeeth L, Hingorani AD, MacAllister RJ (2006). Renoprotective effects of renin-angiotensin-system inhibitors - Reply. LANCET, 367(9514), 900 - 902.
    • Casas JP, Cavalleri GL, Bautista LE, Smeeth L, Humphries SE, Hingorani AD (2006). Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol, 164, 921 - 935.
    • Casas JP, Hingorani AD, MacAllister RJ, Smeeth L (2006). Progression of renal disease - can we forget about inhibition of the renin-angiotensin system? Authors' reply. NEPHROL DIAL TRANSPL, 21(9), 2352 - 2353. doi:10.1093/ndt/gfl316
    • Perel P, Casas JP, Ortiz Z, Miranda JJ (2006). Noncommunicable diseases and injuries in Latin America and the Caribbean: time for action. PLoS Med, 3, e344 - .
    • Quiros FR, Morillo CA, Casas JP, Cubillos LA, Silva FA (2006). CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973]. Trials, 7, 21 - .
    • Serrano NC, Diaz LA, Paez MC, Mesa CM, Cifuentes R, Monterrosa A, Gonzalez A, Smeeth L, Hingorani AD, Casas JP (2006). Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias. PLoS Med, 3, e520 - .
    • Ioannidis JP, Gwinn M, Little J, Higgins JP, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Dolan S, Duncan R, Gruis NA, Hartge P, Hashibe M, Hunter DJ, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, O'Brien TR, Petersen G, Riboli E, Salanti G, Seminara D, Smeeth L, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Khoury MJ (2006). A road map for efficient and reliable human genome epidemiology. Nat Genet, 38, 3 - 5.
    • Bautista LE, Smeeth L, Hingorani AD, Casas JP (2006). Estimation of bias in nongenetic observational studies using "mendelian triangulation". Ann Epidemiol, 16, 675 - 680.
    • Casas JP, Cooper J, Miller GJ, Hingorani AD, Humphries SE (2006). Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies. Ann Hum Genet, 70, 145 - 169.
    • Casas JP, Shah T, Cooper J, Hawe E, McMahon AD, Gaffney D, Packard CJ, O'Reilly DS, Juhan-Vague I, Yudkin JS, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Kooistra T, Stephens JW, Hurel SJ, Livingstone S, Colhoun HM, Miller GJ, Bautista LE, Meade T, Sattar N, Humphries SE, Hingorani AD (2006). Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol, 35, 922 - 931.
    • Healy DG, Abou-Sleiman PM, Casas JP, Ahmadi KR, Lynch T, Gandhi S, Muqit MM, Foltynie T, Barker R, Bhatia KP, Quinn NP, Lees AJ, Gibson JM, Holton JL, Revesz T, Goldstein DB, Wood NW (2006). UCHL-1 is not a Parkinson's disease susceptibility gene. Ann Neurol, 59, 627 - 633.
    • Hingorani AD, Shah T, Casas JP (2006). Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease risk. Eur Heart J, 27, 1261 - 1263.
    • Yu CK, Casas JP, Savvidou MD, Sahemey MK, Nicolaides KH, Hingorani AD (2006). Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis. BMC Pregnancy Childbirth, 6, 7 - .


    • Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD (2005). Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet, 365, 224 - 232.
    • Silva SY, Villamizar C, Villamizar N, Silva F, Luengas C, Casas JP, Villa-Roel C, Lopez-Jaramillo P (2005). Colombian study to assess the use of noninvasive determination of the endothelium-mediated vasodilation (CANDEV) II: does location of the occlusion device affects the accuracy of the diagnosis?. Endothelium, 12, 107 - 111.
    • D'Aiuto F, Casas JP, Shah T, Humphries SE, Hingorani AD, Tonetti MS (2005). C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus. Atherosclerosis, 179, 413 - 417.
    • Casas JP, Chua W, Loukogeorgakis S, Vallance P, Smeeth L, Hingorani AD, MacAllister RJ (2005). Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet, 366, 2026 - 2033.


    • Serrano NC, Casas JP, Diaz LA, Paez C, Mesa CM, Cifuentes R, Monterrosa A, Bautista A, Hawe E, Hingorani AD, Vallance P, Lopez-Jaramillo P (2004). Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. Hypertension, 44, 702 - 707.
    • Casas JP, Hingorani AD, Humphries SE, Smeeth L, Bautista LE (2004). Do meta-analyses of association studies of endothelial nitric oxide synthase variants and ischemic heart disease provide conclusive answers? Response. CIRCULATION, 110(11), E305 - E306.
    • Casas JP, Bautista LE, Humphries SE, Hingorani AD (2004). Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation, 109, 1359 - 1365.
    • MacAllister R, Hingorani AD, Casas JP (2004). Ximelagatran or warfarin in atrial fibrillation?. Lancet, 363, 735 - 736.
    • Cubillos-Garzon LA, Casas JP, Morillo CA, Bautista LE (2004). Congestive heart failure in Latin America: the next epidemic. Am Heart J, 147, 412 - 417.
    • Healy DG, Abou-Sleiman PM, Lees AJ, Casas JP, Quinn N, Bhatia K, Hingorani AD, Wood NW (2004). Tau gene and Parkinson's disease: a case-control study and meta-analysis. J Neurol Neurosurg Psychiatry, 75, 962 - 965.
    • Maas R, Boger RH, Schwedhelm E, Casas JP, Lopez-Jaramillo P, Serrano N, Diaz LA (2004). Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia. JAMA, 291, 823 - 824.
    • Casas JP, Hingorani AD, Bautista LE, Sharma P (2004). Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol, 61, 1652 - 1661.


    • Casas JP, Cubillos-Garzon LA, Morillo CA (2003). Regional pathologies and globalization of clinical trials: has the time for regional trials arrived?. Circulation, 107, e194 - .
    • Perez M, Casas JP, Cubillos-Garzon LA, Serrano NC, Silva F, Morillo CA, Lopez-Jaramillo P (2003). Using waist circumference as a screening tool to identify Colombian subjects at cardiovascular risk. Eur J Cardiovasc Prev Rehabil, 10, 328 - 335.
    • Cubillos-Garzon LA, Casas JP, Morillo CA (2003). Sildenafil in secondary pulmonary hypertension. Int J cardiol, 89, 101 - 102.


    • Lopez-Jaramillo P, Casas JP (2002). Blockade of endothelial enzymes: new therapeutic targets. J HUM HYPERTENS, 16, S100 - S103. doi:10.1038/sj/jhh/1001353
    • Lopez-Jaramillo P, Casas JP, Morillo CA (2002). C-reactive protein and cardiovascular diseases in Andean population. Circulation, 105, E10 - .
    • Lopez-Jaramillo P, Casas JP (2002). Endothelial dysfunction, angiotensin-converting enzyme inhibitors and calcium antagonists. J Hum Hypertens, 16 Suppl 1, S34 - S37.


    • Lopez-Jaramillo P, Casas JP, Serrano N (2001). Preeclampsia: from epidemiological observations to molecular mechanisms. Braz J Med Biol Res, 34, 1227 - 1235.
    • Lopez-Jaramillo P, Casas JP, Bautista L, Serrano NC, Morillo CA (2001). An integrated proposal to explain the epidemic of cardiovascular disease in a developing country. From socioeconomic factors to free radicals. Cardiology, 96, 1 - 6.
    • Bautista LE, Lopez-Jaramillo P, Vera LM, Casas JP, Otero AP, Guaracao AI (2001). Is C-reactive protein an independent risk factor for essential hypertension?. J Hypertens, 19, 857 - 861.