Prof Jeremy Brockes

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Name: Jeremy Brockes Email: j.brockes@ucl.ac.uk
Title: Prof Tel:
Department: Structural & Molecular Biology Fax: 2076794494
Position: MRC Non-Clinical Research Professor Address: ISMB, Darwin Building, Gower Street, London, WC1E 6BT
Research Domain: Neuroscience, Personalised Medicine, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

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Research Description

see my web site at Structural and Molecular Biology as above

The most extensive repertoire of regenerative ability in adult vertebrates is found in the various species of salamander.My interests are in the cellular and molecular mechanisms underlying regeneration in salamanders, particularly limb regeneration. Limb regeneration proceeds by formation of the limb blastema, a mound of mesenchymal stem cells. The distinctive questions center around the origin and identity of the blastema. How does it arise by reprogramming of differentiated cells at the amputation plane? How is growth of the blastema regulated by the requirement for concomitant regeneration of peripheral nerves? How is the positional identity of blastemal cells determined ?

Recent work has identified molecules that are implicated in positional identity and nerve dependence. This has also provided an explanation of how nerve dependence is established in the development of the limb. Our interest in reprogramming in this context centers on the regulation of tumor suppressor genes in regeneration which seems to be critical for the early stages.

The most difficult questions of all are to understand regeneration as an evolutionary variable. Why can a salamander regenerate its limb and why does a mammal lack this ability? Our evidence from molecular phylogeny suggests that regeneration may have evolved locally in salamanders, rather than being a purely ancestral mechanism. This viewpoint of local evolution is strongly supported by recent transcriptomic and proteomic analysis by other laboratories. This is turn raises questions about the roles of salamander-specific gene products, and suggests new strategies for promoting regeneration in mammals.


Research Activities

Mechanisms underlying regeneration in salamanders

Education Description

Teaching second and third year molecular biology I give lectures on various topics in third year and tutorials in second year, as well as taking third year students for lab and literature projects.

UCL Collaborators

External Collaborators

Publications

    2013

    • Yun MH, Gates PB, Brockes JP (2013). Regulation of p53 is critical for vertebrate limb regeneration.. Proc Natl Acad Sci U S A, , - . doi:10.1073/pnas.1310519110

    2012

    • Kumar A, Brockes JP (2012). Nerve dependence in tissue, organ, and appendage regeneration.. Trends Neurosci, 35(11), 691 - 699. doi:10.1016/j.tins.2012.08.003

    2011

    • Kumar A, Delgado JP, Gates PB, Neville G, Forge A, Brockes JP (2011). The aneurogenic limb identifies developmental cell interactions underlying vertebrate limb regeneration.. Proc Natl Acad Sci U S A, 108(33), 13588 - 13593. doi:10.1073/pnas.1108472108
    • Shaikh N, Gates PB, Brockes JP (2011). The Meis homeoprotein regulates the axolotl Prod 1 promoter during limb regeneration.. Gene, 484(1-2), 69 - 74. doi:10.1016/j.gene.2011.06.003
    • Blassberg RA, Garza-Garcia A, Janmohamed A, Gates PB, Brockes JP (2011). Functional convergence of signalling by GPI-anchored and anchorless forms of a salamander protein implicated in limb regeneration.. J Cell Sci, 124, 47 - 56. doi:10.1242/jcs.076331

    2010

    • Garza-Garcia AA, Driscoll PC, Brockes JP (2010). Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders. Integrative and Comparative Biology, 50, 528 - 535.
    • Kumar A, Nevill G, Brockes JP, Forge A (2010). A comparative study of gland cells implicated in the nerve dependence of salamander limb regeneration.. J Anat, 217(1), 16 - 25. doi:10.1111/j.1469-7580.2010.01239.x
    • Godwin JW, Liem KF, Brockes JP (2010). Tissue factor expression in newt iris coincides with thrombin activation and lens regeneration.. Mech Dev, 127(7-8), 321 - 328. doi:10.1016/j.mod.2010.04.004

    2008

    • Brockes JP, Kumar A (2008). Comparative aspects of animal regeneration. Annual Review of Cell and Developmental Biology, 24, 525 - 549.

    2007

    • Kumar A, Brockes JP (2007). Preparation of cultured myofibers from larval salamander limbs for cellular plasticity studies. Nature Protocols, 209, 939 - 947. doi:10.1038/nprot.2007.134
    • Kumar A, Godwin JW, Gates PB, Garza-Garcia AA, Brockes JP (2007). Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate.. Science, 318(5851), 772 - 777. doi:10.1126/science.1147710
    • Kumar A, Gates PB, Brockes JP (2007). Positional identity of adult stem cells in salamander limb regeneration. Comptes Rendus Biologies, 330, 485 - 490. doi:10.1016/j.crvi.2007.01.006

    2006

    • Godwin JG, Brockes JP (2006). Regeneration, tissue injury and the immune response. Journal of Anatomy, 209, 423 - 432.

    2005

    • Brockes JP, Kumar A (2005). Appendage regeneration in adult vertebrates and implications for regenerative medicine. Science, 310, 1919 - 1923. doi:10.1126/science.1115200
    • Duckmanton A, Kumar A, Chang YT, Brockes JP (2005). A single-cell analysis of myogenic dedifferentiation induced by small molecules. Chemistry and Biology, 12, 1117 - 1126.

    2004

    • Brockes JP, Martin P (2004). New directions in tissue repair and regeneration - Papers of a Discussion Meeting held at the Royal Society on 24 and 25 September 2003 - Introduction. PHILOS T R SOC B, 359(1445), 743 - 743. doi:10.1098/rstb.2004.1473
    • Kumar A, Velloso C, Imokawa Y, Brockes JP (2004). The regenerative plasticity of isolated urodele myofibers and its regulation by Msx1.. PLoS Biology, 2(8), 1168 - 1176. doi:10.1371/journal.pbio.0020218
    • Imokawa Y, Gates PB, Chang Y-T, Simon H-G, Brockes JP (2004). Distinctive expression of Myf5 in relation to differentiation and plasticity of newt muscle cells.. International Journal of Developmental Biology, 48(4), 285 - 291.
    • Straube WL, Brockes JP, Drechsel DN, Tanaka EM (2004). Plasticity and reprogramming of differentiated cells in amphibian regeneration: partial purification of a serum factor that triggers cell cycle re-entry in differentiated muscle cells.. Cloning Stem Cells, 6(4), 333 - 344. doi:10.1089/clo.2004.6.333
    • Moroncini G, Kanu N, Solforosi L, Abalos G, Telling GC, Head M, Ironside J, Brockes JP, Burton DR, Williamson AR (2004). Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc. Proceedings of the National Academy of Sciences of the United States of America, 101(28), 10404 - 10409.
    • Brockes JP, Kanu N (2004). The prion protein in cell culture. In Telling GC (Ed.), Prions and Prion Diseases: Current Perspectives (pp. 57 - 81). : Taylor & Francis.
    • Imokawa Y, Simon A, Brockes JP (2004). A critical role for thrombin in vertebrate lens regeneration. Philosophical Transactions of the Royal Society B: Biological Sciences, 359(1445), 765 - 776.

    2003

    • Imokawa Y, Brockes JP (2003). Selective activation of thrombin is a critical determinant for vertebrate lens regeneration.. Current Biology, 13, 877 - 881. doi:10.1016/S0960-9822(03)00294-X
    • Bettencourt-Dias M, Mittnacht S, Brockes JP (2003). Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes. Journal of Cell Science, 116, 4001 - 4009.

    2002

    • Kanu N, Dreschsel DN, Imokawa Y, Williamson RA, Birkett CR, Bostock CJ, Brockes JP (2002). Transfer of scrapie prion infectivity by cell contact in culture. Current Biology, 12, 523 - 530.
    • Brockes JP, Kumar A (2002). Plasticity and reprogramming of differentiated cells in amphibian regeneration. Nature Reviews Molecular Cell Biology, 3, 566 - 574.
    • Morais da Silva S, Gates PB, Brockes JP (2002). The newt ortholog of CD59 is implicated in proximodistal identity during amphibian limb regeneration. Developmental Cell, 3, 547 - 555. doi:10.1016/S1534-5807(02)00288-5
    • Simon A, Brockes JP (2002). Thrombin activation of S-phase re-entry by cultured pigmented epithelial cells of adult newt iris. Experimental Cell Research, 281, 101 - 106.

    2001

    • Brockes JP, Velloso CP, Kumar A (2001). Regeneration as an evolutionary variable. Journal of Anatomy, 199, 3 - 12.
    • Silva SM, Gates PB, Eib D, Martens GM, Brockes JP (2001). The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development. Mechanisms of Development, 104, 125 - 128.
    • Velloso CP, Simon A, Brockes JP (2001). Mammalian postmitotic nuclei re-enter the cell cycle after serum stimulation in newt/mouse hybrid myotubes. Current Biology, 11, 855 - 858.

    2000

    • Kumar A, Velloso CP, Brockes JP (2000). Plasticity of postmitotic myotubes in adult regeneration. DEV BIOL, 222(1), 231 - 231.
    • Kumar A, Velloso CP, Imokawa Y, Brockes JP (2000). Plasticity of retrovirus-labelled myotubes in the newt limb regeneration blastema. Developmental Biology, 218(2), 125 - 136.
    • (2000). Generation of mononucleate cells from post-mitotic myotubes proceeds in the absence of cell cycle progression. Differentiation, 66, 239 - 246.

    1999

    • Brockes JP (1999). Topics in prion cell biology.. Curr Opin Neurobiol, 9(5), 571 - 577. doi:10.1016/S0959-4388(99)00016-1
    • Brockes JP (1999). Topics in prion cell biology [In Process Citation]. Current Opinion in Neurobiology, 9(5), 571 - 577.
    • Tanaka EM, Drechsel DN, Brockes JP (1999). Thrombin regulates S-phase re-entry by cultured newt myotubes. Current Biology, 9(15), 792 - 799.

    1998

    • Brockes JP (1998). Regeneration and cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1377(1), 1 - 11.
    • Stark DR, Gates PB, Brockes JP, Ferretti PA (1998). A hedgehop family member is expressed throughout regenerating and developing limbs. Developmental Dynamics, 212, 352 - 363.
    • Cash DM, Gates PB, Imokawa Y, Brockes JP (1998). Identification of newt Connective Tissue Growth Factor as a target of retinoid regulation in limb blastemal cells. Gene, 222, 119 - 124.
    • Brockes JP (1998). Progenitor cells for regeneration: dedifferentiation and immortalisation. In Ferretti P, Geraudie J (Ed.), Cellular and Molecular Basis of Regeneration; from Invertebrates to Humans (pp. 63 - 77). : John Wiley and Sons Limited.
    • Tanaka EM, Brockes JP (1998). A target of thrombin activation promotes cell cycle re-entry by urodele muscle cells. Wound Repair and Regeneration, 6, 371 - 381.
    • Brockes JP (1998). Regeneration and cancer.. Biochim Biophys Acta, 1377(1), M1 - 11.
    • Powell AJ, Gates PB, Wylie D, Velloso C, Brockes JP, Jat PS (1998). Immortalization of rat embryo fibroblasts by a 3'-untranslated region from the newt limb blastema. Experimental Cell Research, 240, 252 - 262.

    1997

    • (1997). Amphibian limb regeneration - rebuilding a complex structure. Science, 276, 81 - 87.
    • (1997). Newt myotubes re-enter the cell cycle by phosphorylation of the retinoblastoma protein. J CELL BIOL, 136, 155 - 165.

    1996

    • Viviano CM, Brockes JP (1996). Is retinoic acid an endogenous ligand during urodele limb regeneration?. Int J Dev Biol, 40(4), 817 - 822.
    • Pecorino LT, Entwistle A, Brockes JP (1996). Activation of a single retinoic acid receptor isoform mediates proximodistal respecification.. Curr Biol, 6(5), 563 - 569.
    • Brockes JP (1996). Retinoid signalling and retinoid receptors in amphibian limb regeneration.. Biochem Soc Symp, 62, 137 - 142.
    • Pecorino LT, Brockes JP, Entwistle A (1996). Semi-automated positional analysis using laser scanning microscopy of cells transfected in a regenerating newt limb.. J Histochem Cytochem, 44(6), 559 - 569.
    • Gann AAF, Gates PB, Stark D, Brockes JP (1996). Receptor isoform specificity in a cellular response to retinoic acid (vol 263, pg 673, 1996). P ROY SOC LOND B BIO, 263(1372), 941 - 941.

    1995

    • VIVIANO CM, HORTON CE, MADEN M, BROCKES JP (1995). SYNTHESIS AND RELEASE OF 9-CIS RETINOIC ACID BY THE URODELE WOUND EPIDERMIS. DEVELOPMENT, 121(11), 3753 - 3762.
    • Crews L, Gates PB, Brown R, Joliot A, Foley C, Brockes JP, Gann AA (1995). Expression and activity of the newt Msx-1 gene in relation to limb regeneration.. Proc Biol Sci, 259(1355), 161 - 171. doi:10.1098/rspb.1995.0024

    1994

    • Brockes JP, Lo DC (1994). Reversibility of the mononucleate-to-multinucleate myogenic transition during amphibian limb regeneration.. Eye (Lond), 8 ( Pt 2), 151 - 154. doi:10.1038/eye.1994.38
    • Pecorino LT, Lo DC, Brockes JP (1994). Isoform-specific induction of a retinoid-responsive antigen after biolistic transfection of chimaeric retinoic acid/thyroid hormone receptors into a regenerating limb.. Development, 120(2), 325 - 333.
    • Brockes JP (1994). New approaches to amphibian limb regeneration.. Trends Genet, 10(5), 169 - 173.

    1993

    • Doucas V, Brockes JP, Yaniv M, de Thé H, Dejean A (1993). The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1.. Proc Natl Acad Sci U S A, 90(20), 9345 - 9349.
    • Schilthuis JG, Gann AA, Brockes JP (1993). Chimeric retinoic acid/thyroid hormone receptors implicate RAR-alpha 1 as mediating growth inhibition by retinoic acid.. EMBO J, 12(9), 3459 - 3466.
    • Lo DC, Allen F, Brockes JP (1993). Reversal of muscle differentiation during urodele limb regeneration.. Proc Natl Acad Sci U S A, 90(15), 7230 - 7234.
    • Ragsdale CW, Gates PB, Hill DS, Brockes JP (1993). Delta retinoic acid receptor isoform delta 1 is distinguished by its exceptional N-terminal sequence and abundance in the limb regeneration blastema.. Mech Dev, 42(1-2), 113 - .
    • RAGSDALE CW, GATES PB, HILL DS, BROCKES JP (1993). DELTA-RETINOIC ACID RECEPTOR ISOFORM-DELTA(1) IS DISTINGUISHED BY ITS EXCEPTIONAL N-TERMINAL SEQUENCE AND ABUNDANCE IN THE LIMB REGENERATION BLASTEMA (VOL 40, PG 99, 1992). MECH DEVELOP, 42(1-2), 113 - 113.
    • Hill DS, Ragsdale CW, Brockes JP (1993). Isoform-specific immunological detection of newt retinoic acid receptor delta 1 in normal and regenerating limbs.. Development, 117(3), 937 - 945.
    • Brockes JP (1993). Expression of retinoic acid receptors in the normal and regenerating urodele limb.. Prog Clin Biol Res, 383B, 715 - 723.
    • Ragsdale CW, Gates PB, Hill DS, Brockes JP (1993). Delta retinoic acid receptor isoform delta 1 is distinguished by its exceptional N-terminal sequence and abundance in the limb regeneration blastema.. Mech Dev, 40(1-2), 99 - 112.

    1992

    • Brockes JP (1992). Introduction of a retinoid reporter gene into the urodele limb blastema.. Proc Natl Acad Sci U S A, 89(23), 11386 - 11390.
    • Ragsdale CW, Gates PB, Brockes JP (1992). Identification and expression pattern of a second isoform of the newt alpha retinoic acid receptor.. Nucleic Acids Res, 20(21), 5851 - .

    1991

    • Brown R, Brockes JP (1991). Identification and expression of a regeneration-specific homeobox gene in the newt limb blastema.. Development, 111(2), 489 - 496.
    • Brockes JP (1991). Some current problems in amphibian limb regeneration.. Philos Trans R Soc Lond B Biol Sci, 331(1261), 287 - 290. doi:10.1098/rstb.1991.0018
    • Ragsdale CW, Brockes JP (1991). Retinoids and their targets in vertebrate development.. Curr Opin Cell Biol, 3(6), 928 - 934.
    • Ferretti P, Brockes JP, Brown R (1991). A newt type II keratin restricted to normal and regenerating limbs and tails is responsive to retinoic acid.. Development, 111(2), 497 - 507.
    • BROWN R, BROCKES JP (1991). THE ROLE OF HOMEOBOX GENES IN AMPHIBIAN LIMB DEVELOPMENT AND REGENERATION.
    • Ferretti P, Brockes JP (1991). Cell origin and identity in limb regeneration and development.. Glia, 4(2), 214 - 224. doi:10.1002/glia.440040213

    1990

    • Brockes JP (1990). Retinoic acid and limb regeneration.. J Cell Sci Suppl, 13, 191 - 198.
    • Ferretti P, Brockes JP (1990). The monoclonal antibody 22/18 recognizes a conformational change in an intermediate filament of the newt, Notophthalmus viridescens, during limb regeneration.. Cell Tissue Res, 259(3), 483 - 493.
    • BROCKES JP (1990). MOLECULAR MECHANISMS RELEVANT TO REGENERATION.

    1989

    • Ragsdale CW, Petkovich M, Gates PB, Chambon P, Brockes JP (1989). Identification of a novel retinoic acid receptor in regenerative tissues of the newt.. Nature, 341(6243), 654 - 657. doi:10.1038/341654a0
    • Brockes JP (1989). Retinoids, homeobox genes, and limb morphogenesis.. Neuron, 2(4), 1285 - 1294.

    1988

    • Savard P, Gates PB, Brockes JP (1988). Position dependent expression of a homeobox gene transcript in relation to amphibian limb regeneration.. EMBO J, 7(13), 4275 - 4282.
    • Casimir CM, Gates PB, Patient RK, Brockes JP (1988). Evidence for dedifferentiation and metaplasia in amphibian limb regeneration from inheritance of DNA methylation.. Development, 104(4), 657 - 668.
    • Gordon H, Brockes JP (1988). Appearance and regulation of an antigen associated with limb regeneration in Notophthalmus viridescens.. J Exp Zool, 247(3), 232 - 243. doi:10.1002/jez.1402470306
    • Casimir CM, Gates PB, Ross-Macdonald PB, Jackson JF, Patient RK, Brockes JP (1988). Structure and expression of a newt cardio-skeletal myosin gene. Implications for the C value paradox.. J Mol Biol, 202(2), 287 - 296.
    • Ferretti P, Brockes JP (1988). Culture of newt cells from different tissues and their expression of a regeneration-associated antigen.. J Exp Zool, 247(1), 77 - 91. doi:10.1002/jez.1402470111
    • Fekete DM, Brockes JP (1988). Evidence that the nerve controls molecular identity of progenitor cells for limb regeneration.. Development, 103(3), 567 - 573.

    1987

    • Brockes JP (1987). The nerve dependence of amphibian limb regeneration.. J Exp Biol, 132, 79 - 91.
    • Brockes JP (1987). Assay and isolation of glial growth factor from the bovine pituitary.. Methods Enzymol, 147, 217 - 225.
    • Fekete DM, Brockes JP (1987). A monoclonal antibody detects a difference in the cellular composition of developing and regenerating limbs of newts.. Development, 99(4), 589 - 602.
    • FEKETE DM, BROCKES JP (1987). THE ANEUROGENIC LIMB - A PUZZLE IN CELL-INTERACTIONS. TRENDS NEUROSCI, 10(9), 364 - 368.

    1986

    • Brockes JP, Breakefield XO, Martuza RL (1986). Glial growth factor-like activity in Schwann cell tumors.. Ann Neurol, 20(3), 317 - 322. doi:10.1002/ana.410200308
    • Brockes JP, Kintner CR (1986). Glial growth factor and nerve-dependent proliferation in the regeneration blastema of Urodele amphibians.. Cell, 45(2), 301 - 306.

    1985

    • Kintner CR, Brockes JP (1985). Monoclonal antibodies to the cells of a regenerating limb.. J Embryol Exp Morphol, 89, 37 - 55.

    1984

    • Kintner CR, Brockes JP (1984). Monoclonal antibodies identify blastemal cells derived from dedifferentiating limb regeneration.. Nature, 308(5954), 67 - 69.
    • Brockes JP (1984). Assays for cholinergic properties in cultured rat Schwann cells.. Proc R Soc Lond B Biol Sci, 222(1226), 121 - 134.
    • Brockes JP (1984). Mitogenic growth factors and nerve dependence of limb regeneration.. Science, 225(4668), 1280 - 1287.
    • Lemke GE, Brockes JP (1984). Identification and purification of glial growth factor.. J Neurosci, 4(1), 75 - 83.
    • KINTNER CR, BROCKES JP (1984). MONOCLONAL-ANTIBODIES IDENTIFY BLASTEMAL CELLS DERIVED FROM DEDIFFERENTIATING MUSCLE IN NEWT LIMB REGENERATION. NATURE, 308(5954), 67 - 69.

    1983

    • Fritz LC, Brockes JP (1983). Immunochemical properties and cytochemical localization of the voltage-sensitive sodium channel from the electroplax of the eel (Electrophorus electricus).. J Neurosci, 3(11), 2300 - 2309.
    • Lemke GE, Brockes JP (1983). Glial growth factor: a mitogenic polypeptide of the brain and pituitary.. Fed Proc, 42(9), 2627 - 2629.
    • Fryxell KJ, Balzer DR, Brockes JP (1983). Development and applications of a solid-phase radioimmunoassay for the PO protein of peripheral myelin.. J Neurochem, 40(2), 538 - 546.
    • Fritz LC, Moore HP, Raftery MA, Brockes JP (1983). Immunochemical studies of the voltage-sensitive sodium channel from the electroplax of the eel Electrophorus electricus.. Cold Spring Harb Symp Quant Biol, 48 Pt 1, 181 - 185.
    • Brockes JP (1983). Glial growth factor--a new component of the brain and pituitary.. Birth Defects Orig Artic Ser, 19(4), 277 - 285.

    1982

    • Moore HP, Fritz LC, Raftery MA, Brockes JP (1982). Isolation and characterization of a monoclonal antibody against the saxitoxin-binding component from the electric organ of the eel Electrophorus electricus.. Proc Natl Acad Sci U S A, 79(5), 1673 - 1677.
    • Pappenheimer AM, Harper AA, Moynihan M, Brockes JP (1982). Diphtheria toxin and related proteins: effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells.. J Infect Dis, 145(1), 94 - 102.
    • BROCKES JP (1982). STUDIES ON CULTURED SCHWANN-CELLS. IN VITRO CELL DEV B, 18(3), 321 - 321.

    1981

    • Brockes JP, Fryxell KJ, Lemke GE (1981). Studies on cultured Schwann cells: the induction of myelin synthesis, and the control of their proliferation by a new growth factor.. J Exp Biol, 95, 215 - 230.
    • Fritz LC, Brockes JP (1981). Clustering of ion channels at the node of Ranvier.. Nature, 291(5812), 190 - .

    1980

    • Brockes JP, Lemke GE, Balzer DR (1980). Purification and preliminary characterization of a glial growth factor from the bovine pituitary.. J Biol Chem, 255(18), 8374 - 8377.
    • Brockes JP, Raff MC, Nishiguchi DJ, Winter J (1980). Studies on cultured rat Schwann cells. III. Assays for peripheral myelin proteins.. J Neurocytol, 9(1), 67 - 77.
    • LEMKE GE, BALZER DR, STYGALL KA, BROCKES JP (1980). GLIAL GROWTH-FACTOR - A NEW COMPONENT OF THE BRAIN AND PITUITARY. J CELL BIOL, 87(2), A74 - A74.

    1979

    • Brockes JP, Raff MC (1979). Studies on cultured rat Schwann cells. II. Comparison with a rat Schwann cell line.. In Vitro, 15(10), 772 - 778.
    • Brockes JP, Fields KL, Raff MC (1979). Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve.. Brain Res, 165(1), 105 - 118.
    • Raff MC, Brockes JP, Fields KL, Mirsky R (1979). Neural cell markers: the end of the beginning.. Prog Brain Res, 51, 17 - 22. doi:10.1016/S0079-6123(08)61290-X

    1978

    • Raff MC, Abney E, Brockes JP, Hornby-Smith A (1978). Schwann cell growth factors.. Cell, 15(3), 813 - 822.
    • Raff MC, Hornby-Smith A, Brockes JP (1978). Cyclic AMP as a mitogenic signal for cultured rat Schwann cells.. Nature, 273(5664), 672 - 673.
    • Fields KL, Brockes JP, Mirsky R, Wendon LM (1978). Cell surface markers for distinguishing different types of rat dorsal root ganglion cells in culture.. Cell, 14(1), 43 - 51.

    1977

    • Brockes JP, Fields KL, Raff MC (1977). A surface antigenic marker for rat Schwann cells.. Nature, 266(5600), 364 - 366.

    1976

    • Brockes JP, Berg DK, Hall ZW (1976). The biochemical properties and regulation of acetylcholine receptors in normal and denervated muscle.. Cold Spring Harb Symp Quant Biol, 40, 253 - 262.

    1975

    • Brockes JP, Hall ZW (1975). Acetylcholine receptors in normal and denervated rat diaphragm muscle. I. Purification and interaction with [125I]-alpha-bungarotoxin.. Biochemistry, 14(10), 2092 - 2099.
    • Brockes JP, Hall ZW (1975). Acetylcholine receptors in normal and denervated rat diaphragm muscle. II. Comparison of junctional and extrajunctional receptors.. Biochemistry, 14(10), 2100 - 2106.
    • BROCKES JP, HALL ZW (1975). ACETYLCHOLINE RECEPTORS IN NORMAL AND DENERVATED MUSCLE. BIOPHYS J, 15(2), A332 - A332.
    • Brockes JP, Hall ZW (1975). Synthesis of acetylcholine receptor by denervated rat diaphragm muscle.. Proc Natl Acad Sci U S A, 72(4), 1368 - 1372.

    1974

    • Brockes JP, Brown PR, Murray K (1974). Nucleotide sequences at the sites of action of the deoxyribonucleic acid modification enzyme of bacteriophage P1.. J Mol Biol, 88(2), 437 - 443.

    1973

    • Brockes JP (1973). The deoxyribonucleic acid-modification enzyme of bacteriophage P1. Subunit structure.. Biochem J, 133(4), 629 - 633.

    1972

    • Brockes JP, Brown PR, Murray K (1972). The deoxyribonucleic acid modification enzyme of bacteriophage P1.. Biochem J, 127(1), 1 - 10.
    • BROCKES JP, BROWN PR, MURRAY K (1972). DEOXYRIBONUCLEIC ACID MODIFICATION ENZYME OF BACTERIOPHAGE P1 - PURIFICATION AND PROPERTIES. BIOCHEM J, 127(1), 1 - &.