Prof Jenny Morgan

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Personal Profile

Name: Jenny Morgan Email: jennifer.morgan@ucl.ac.uk
Title: Prof Tel: 0207 905 2874
Department: ICH - Molecular Neurosciences Fax:
Position: Professor of Cell Biology Address: Dubowitz Neuromuscular Centre, Institute of Child Health, UCL, 30 Guildford St, London, WC1N1EH
Research Domain: Populations & Lifelong Health, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page:  

Profile

Research Description

The aim of my research programme is to understand the biology of skeletal muscle, with particular emphasis on identifying the cell types that contribute to muscle regeneration and how they may be manipulated to enhance muscle repair and regeneration.

Research Activities

Paediatric Neurology

Stem cells and skeletal muscle regeneration

Education Description

UCL Collaborators

Prof Adrian Thrasher; Prof Michael Duchen; Prof Mary Reilly; Prof William Mckenna; Prof Francesco Muntoni; Prof Perry Elliott

External Collaborators

Publications

    2013

    • Boldrin L, Morgan JE (2013). Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle.. PLoS One, 8(1), e54599 - . doi:10.1371/journal.pone.0054599
    • Calhabeu F, Hayashi S, Morgan JE, Relaix F, Zammit PS (2013). Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells. ONCOGENE, 32(5), 651 - 662. doi:10.1038/onc.2012.73
    • Briggs D, Morgan JE (2013). Recent progress in satellite cell/myoblast engraftment -- relevance for therapy.. FEBS J, 280(17), 4281 - 4293. doi:10.1111/febs.12273

    2012

    • Boldrin L, Neal A, Zammit PS, Muntoni F, Morgan JE (2012). Donor satellite cell engraftment is significantly augmented when the host niche is preserved and endogenous satellite cells are incapacitated.. Stem Cells, 30(9), 1971 - 1984. doi:10.1002/stem.1158
    • Ross J, Benn A, Jonuschies J, Boldrin L, Muntoni F, Morgan JE, Hewitt JE, Brown SC (2012). Defects in glycosylation impair satellite stem cell function and niche composition in the muscles of the dystrophic large mouse. Stem Cells, 30(10), 2330 - 2341. doi:10.1002/stem.1197
    • Cirak S, Feng L, Anthony K, Arechavala-Gomeza V, Torelli S, Sewry C, Morgan JE, Muntoni F (2012). Restoration of the dystrophin-associated glycoprotein complex after exon skipping therapy in Duchenne muscular dystrophy.. Mol Ther, 20(2), 462 - 467. doi:10.1038/mt.2011.248
    • Boldrin L, Morgan JE (2012). Labelling satellite cells on human muscle fibres.
    • Neal A, Boldrin L, Morgan JE (2012). The satellite cell in male and female, developing and adult mice: evidence for functionally distinct stem cell populations.
    • Neal A, Boldrin L, Morgan JE (2012). The satellite cell in male and female, developing and adult mouse muscle: distinct stem cells for growth and regeneration.. PLoS One, 7(5), e37950 - . doi:10.1371/journal.pone.0037950

    2011

    • Zaharieva I, Cirak S, Morgan JE, Muntoni F (2011). Identifying genomic pre-clinical biomarkers for diagnostics and therapeutics of Duchenne muscular dystrophy.
    • Reza M, Laval S, Morgan JE, Muntoni F, Bushby K, Straub V, Lochmuller H (2011). Optimal dystrophin mini-construct for gene delivery to skeletal muscle.
    • Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Garralda ME, Wells D, Dickson G, Wood MJA, Wilton SD, Straub V, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F (2011). Exon skipping and dystrophin restoration in Duchenne muscular dystrophy patients after systemic phosphorodiamidate morpholino oligomer treatment.
    • Asfahani R, Meng J, Muntoni F, Morgan JE (2011). Human skeletal-muscle derived CD133+cells as a promising tool for cell therapy of Duchenne muscular dystrophy.
    • Anthony K, Morgan JE, Muntoni F (2011). Quantification of exon skipping in Duchenne muscular dystrophy by qRT-PCR.
    • Meng J, Adkin CF, Xu SW, Muntoni F, Morgan JE (2011). Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice.. PLoS One, 6(3), e17454 - . doi:10.1371/journal.pone.0017454
    • Kinali M, Arechavala-Gomeza V, Cirak S, Glover A, Guglieri M, Feng L, Hollingsworth KG, Hunt D, Jungbluth H, Roper HP, Quinlivan RM, Gosalakkal JA, Jayawant S, Nadeau A, Hughes-Carre L, Manzur AY, Mercuri E, Morgan JE, Straub V, Bushby K, Sewry C, Rutherford M, Muntoni F (2011). Muscle histology vs MRI in Duchenne muscular dystrophy.. Neurology, 76(4), 346 - 353. doi:10.1212/WNL.0b013e318208811f
    • Meng J, Muntoni F, Morgan JE (2011). Stem cells to treat muscular dystrophies - where are we?. Neuromuscul Disord, 21(1), 4 - 12. doi:10.1016/j.nmd.2010.10.004
    • Morgan JE (2011). Satellite cells and skeletal muscle regeneration. doi:10.1016/j.nmd.2011.06.756
    • Kim J, Anthony K, Cloke V, Yau M, Abbs S, Morgan JE (2011). The feasibility of exon skipping to restore the reading frame in DMD patients with duplications.
    • Boldrin L, Zammit PS, Muntoni F, Morgan JE (2011). The host muscle environment has got a profound effect on satellite cell function.
    • Neal A, Boldrin L, Morgan JE (2011). Age and sex related differences in satellite cell number, proliferation and self renewal.
    • Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda ME, Bourke J, Wells DJ, Dickson G, Wood MJ, Wilton SD, Straub V, Kole R, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F (2011). Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study.. Lancet, 378(9791), 595 - 605. doi:10.1016/S0140-6736(11)60756-3
    • Ono Y, Calhabeu F, Morgan JE, Katagiri T, Amthor H, Zammit PS (2011). BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells. CELL DEATH DIFFER, 18(2), 222 - 234. doi:10.1038/cdd.2010.95
    • Anthony K, Cirak S, Torelli S, Tasca G, Feng L, Arechavala-Gomeza V, Armaroli A, Guglieri M, Straathof CS, Verschuuren JJ, Aartsma-Rus A, Helderman-van den Enden P, Bushby K, Straub V, Sewry C, Ferlini A, Ricci E, Morgan JE, Muntoni F (2011). Dystrophin quantification and clinical correlations in Becker muscular dystrophy: implications for clinical trials.. Brain, 134(Pt 12), 3547 - 3559. doi:10.1093/brain/awr291
    • Jonuschies J, Boldrin L, Thrasher A, Morgan JE, Muntoni F (2011). Assessment of potential promoters for lentiviral gene therapy in DMD. HUM GENE THER, 22(10), A5 - A5.
    • Jonuschies J, Boldrin L, Thrasher A, Morgan JE, Muntoni F (2011). Assessment of potential promoters for lentiviral gene therapy in DMD. HUM GENE THER, 22(10), A62 - A63.
    • Muses S, Morgan JE, Wells DJ (2011). Restoration of dystrophin expression using the Sleeping Beauty transposon.. PLoS Curr, 3, RRN1296 - . doi:10.1371/currents.RRN1296
    • Boldrin L, Morgan JE (2011). Human satellite cells: identification on human muscle fibres.. PLoS Curr, 3, RRN1294 - . doi:10.1371/currents.RRN1294
    • Muses S, Morgan JE, Wells DJ (2011). A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies. PLOS ONE, 6(9), - . doi:10.1371/journal.pone.0024826

    2010

    • Ono Y, Boldrin L, Knopp P, Morgan JE, Zammit PS (2010). Functional heterogeneity of muscle satellite cells in both somite-derived and branchiomeric muscles. FASEB JOURNAL, 24, - .
    • Boldrin L, Muntoni F, Morgan JE (2010). Are Human and Mouse Satellite Cells Really the Same?. HEALTH TECHNOL ASSES, 14(42), 941 - 955. doi:10.1369/jhc.2010.956201
    • Cirak S, Feng L, Torelli S, Arechavala-Gomeza V, Kinali M, Shrewsbury S, Morgan JE, Sewry C, Muntoni F (2010). Induction of dystrophin in DMD patients by antisense oligonucleotide AVI-4658 restores the dystrophin glycoprotein complex. doi:10.1016/j.nmd.2010.07.150
    • Johnson D, Reza M, Morgan JE, Barresi R, Lochmuller H, Muntoni F (2010). MRC NMD Biobank service: an overview.
    • Meng J, Beley C, Adkin C, Muntoni F, Garcia L, Morgan JE (2010). Dystrophin expression in DMD pericytes after infection with U7 lentivirus designed to skip dystrophin exon 51.
    • Neal A, Boldrin L, Morgan JE (2010). Satellite cell heterogeneity.
    • Boldrin L, Collins C, Gnocchi V, Zammit P, Morgan JE (2010). Pax3/Pax7 transcriptional activity is in vivo required for muscle differentiation.
    • Briggs D, Boldrin L, Morgan JE (2010). Phenotypic separation of satellite stem cells using flow cytometry.
    • Malerba A, Sharp P, Graham I, Arechavala V, Foster K, Morgan JE, Muntoni F, Wells D, Dickson G (2010). Chronic long term administration of phosphorodiamidate morpholino oligomer profoundly ameliorates activity, muscle strength and phenotype in dystrophic mdx mice.
    • Cirak S, Feng L, Arechavala V, Torelli S, Ganeshaguru K, Kinali M, Shrewsbury S, Morgan JE, Sewry C, Muntoni F (2010). Induction of dystrophin in Duchenne muscular dystrophy patients by antisense oligonucleotide AVI-4658 restores the dystrophin-associated glycoprotein complex.
    • Jonuschies J, Boldrin L, Muntoni F, Morgan JE (2010). Lentivirus-mediated stem cell therapy for Duchenne muscular dystrophy.
    • Malerba A, Sharp P, Graham IR, Arechavala-Gomeza V, Foster K, Morgan JE, Muntoni F, Wells D, Dickson G (2010). Clinically Applicable Dosing Regimens of Phosphorodiamidate Morpholino Oligomer Profoundly Improve Behaviour, Activity, and Dystrophic phenotype in mdx mice.
    • Boldrin L, Muntoni F, Morgan JE (2010). Are human and mouse satellite cells really the same?. J Histochem Cytochem, 58(11), 941 - 955. doi:10.1369/jhc.2010.956201
    • Arechavala-Gomeza V, Kinali M, Feng L, Guglieri M, Edge G, Main M, Hunt D, Lehovsky J, Straub V, Bushby K, Sewry CA, Morgan JE, Muntoni F (2010). Revertant fibres and dystrophin traces in Duchenne muscular dystrophy: implication for clinical trials.. Neuromuscul Disord, 20(5), 295 - 301. doi:10.1016/j.nmd.2010.03.007
    • Morgan JE, Zammit PS (2010). Direct effects of the pathogenic mutation on satellite cell function in muscular dystrophy.. Exp Cell Res, 316(18), 3100 - 3108. doi:10.1016/j.yexcr.2010.05.014
    • Popplewell LJ, Adkin C, Arechavala-Gomeza V, Aartsma-Rus A, de Winter CL, Wilton SD, Morgan JE, Muntoni F, Graham IR, Dickson G (2010). Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials.. Neuromuscul Disord, 20(2), 102 - 110. doi:10.1016/j.nmd.2009.10.013
    • Meng J, Adkin CF, Arechavala-Gomeza V, Boldrin L, Muntoni F, Morgan JE (2010). The contribution of human synovial stem cells to skeletal muscle regeneration.. Neuromuscul Disord, 20(1), 6 - 15. doi:10.1016/j.nmd.2009.11.007
    • Arechavala-Gomeza V, Kinali M, Feng L, Brown SC, Sewry C, Morgan JE, Muntoni F (2010). Immunohistological intensity measurements as a tool to assess sarcolemma-associated protein expression.. Neuropathol Appl Neurobiol, 36(4), 265 - 274. doi:10.1111/j.1365-2990.2009.01056.x
    • Morgan J, Rouche A, Bousero P, Houssaini A, Gross J, Fiszman MY, Alameddine HS (2010). MMP-9 overexpression improves myogenic cell migration and engraftment. Muscle and Nerve, 42(4), 584 - 595.

    2009

    • Kinali M, Arechavala-Gomeza V, Feng L, Cirak S, Hunt D, Adkin C, Guglieri M, Abbs S, Nihoyannopoulos P, Garralda ME, Rutherford M, McCulley C, Popplewell L, Graham IR, Dickson G, Wood MJA, Wells DJ, Wilton SD, Holt T, Kole R, Straub V, Bushby K, Sewry C, Morgan JE, Muntoni F (2009). Restoration of dystrophin expression in Duchenne muscular dystrophy: A single blind, placebo-controlled dose escalation study using morpholino oligomer AVI-4658. doi:10.1016/j.nmd.2009.06.358
    • rechavala-Gomeza V, Kinali M, Feng L, Brown SC, Sewry C, Morgan JE, Muntoni F (2009). Immunohistological intensity measurements as a tool to assess. Neuropathol Appl Neurobiol, , - .
    • Boldrin L, Zammit PS, Muntoni F, Morgan JE (2009). Mature Adult Dystrophic Mouse Muscle Environment Does Not Impede Efficient Engrafted Satellite Cell Regeneration and Self-Renewal. Stem Cells, 27(10), 2478 - 2487.
    • Kinali M, Arechavala-Gomeza V, Feng L, Cirak S, Hunt D, Adkin C, Guglieri M, Ashton E, Abbs S, Nihoyannopoulos P, Garralda ME, Rutherford M, McCulley C, Popplewell L, Graham IR, Dickson G, Wood MJ, Wells DJ, Wilton SD, Kole R, Straub V, Bushby K, Sewry C, Morgan JE, Muntoni F (2009). Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study. Lancet Neurol., 8(10), 918 - 928.
    • Meng J, Adkin CF, rechavala-Gomeza V, Boldrin L, Muntoni F, Morgan JE (2009). The contribution of human synovial stem cells to skeletal. Neuromuscul Disord, , - .
    • Ono Y, Boldrin L, Knopp P, Morgan JE, Zammit PS (2009). Muscle satellite cells are a functionally heterogeneous population in both somite-derived and branchiomeric muscles. Dev.Biol., , - .
    • Collins CA, Gnocchi VF, White RB, Boldrin L, Perez-Ruiz A, Relaix F, Morgan JE, Zammit PS (2009). Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation. PLoS ONE, 4(2), e4475 - .
    • Boldrin L, Zammit P, Muntoni F, Morgan J (2009). The Mature Adult Dystrophic Mouse Muscle Environment Does Not Impede Efficient Engrafted Satellite Cell Regeneration And Self-Renewal. Stem Cells, , - .

    2008

    • Isman O, Roberts ML, Morgan JE, Graham IR, Goldring K, Lawrence-Watt DJ, Lu QL, Dunckley MG, Porter AC, Partridge TA, Dickson G (2008). Adenovirus-based targeting in myoblasts is hampered by nonhomologous vector integration. Hum.Gene Ther., 19(10), 1000 - 1008.
    • Meng J, Morgan JE (2008). Overexpression of MyoD1 in human synovial stem cells facilitates their myogenic differentiation in vitro. doi:10.1016/j.nmd.2008.06.126
    • Boldrin L, Collins CA, Gnocchi VF, Zammit PS, Morgan JE (2008). Pax3/Pax7 transcriptional activity is required both in vitro and in vivo for muscle differentiation. doi:10.1016/j.nmd.2008.06.124

    2007

    • Arechavala-Gomeza V, Graham IR, Popplewell LJ, Adams AM, artsma-Rus A, Kinali M, Morgan JE, van Deutekom JC, Wilton SD, Dickson G, Muntoni F (2007). Comparative analysis of antisense oligonucleotide sequences for targeted skipping of exon 51 during dystrophin pre-mRNA splicing in human muscle. Human Gene Therapy, 18(9), 798 - 810. doi:10.1089/hum.2006.061
    • Morgan J, Muntoni F (2007). Mural cells paint a new picture of muscle stem cells. Nat Cell Biol, 9(3), 249 - 251.
    • Collins CA, Zammit PS, Ruiz AP, Morgan JE, Partridge TA (2007). A population of myogenic stem cells that survives skeletal muscle aging. Stem Cells, 25(4), 885 - 894.
    • Boldrin L, Morgan JE (2007). Activating muscle stem cells: therapeutic potential in muscle diseases. Curr.Opin.Neurol., 20(5), 577 - 582.
    • Chan J, Waddington SN, O'Donoghue K, Kurata H, Guillot PV, Gotherstrom C, Themis M, Morgan JE, Fisk NM (2007). Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse. Stem Cells, 25(4), 875 - 884.
    • Ehrhardt J, Brimah K, Adkin C, Partridge T, Morgan J (2007). Human muscle precursor cells give rise to functional satellite cells in vivo. Neuromuscul.Disord., 17(8), 631 - 638.

    2006

    • Tam JL, Triantaphyllopoulos K, Todd H, Raguz S, de Wit T, Morgan JE, Partridge TA, Makrinou E, Grosveld F, Antoniou M (2006). The human desmin locus: gene organization and LCR-mediated transcriptional control. Genomics, 87(6), 733 - 746.
    • Chan J, O'Donoghue K, Gavina M, Torrente Y, Kennea N, Mehmet H, Stewart H, Watt DJ, Morgan JE, Fisk NM (2006). Galectin-1 induces skeletal muscle differentiation in human fetal mesenchymal stem cells and increases muscle regeneration. Stem Cells, 24(8), 1879 - 1891.
    • Yokota T, Lu QL, Morgan JE, Davies KE, Fisher R, Takeda S, Partridge TA (2006). Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration. J Cell Sci, 119(Pt 13), 2679 - 2687.

    2005

    • Morgan JE (2005). Stem cells to treat muscular dystrophies. Acta Myol., 24(3), 181 - 183.
    • Fisher I, Abraham D, Bouri K, Hoffman EP, Muntoni F, Morgan J (2005). Prednisolone-induced changes in dystrophic skeletal muscle. FASEB J, 19(7), 834 - 836.
    • Ehrhardt J, Morgan J (2005). Regenerative capacity of skeletal muscle. Curr.Opin.Neurol., 18(5), 548 - 553.
    • Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA, Morgan JE (2005). Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell, 122(2), 289 - 301. doi:10.1016/j.cell.2005.05.010
    • Chan J, O'Donoghue K, de la FJ, Roberts IA, Kumar S, Morgan JE, Fisk NM (2005). Human fetal mesenchymal stem cells as vehicles for gene delivery. Stem Cells, 23(1), 93 - 102.
    • Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A, Partridge T, Buckingham M (2005). Direct isolation of satellite cells for skeletal muscle regeneration. Science, 309(5743), 2064 - 2067. doi:10.1126/science.1114758

    2004

    • Pattwell DM, McArdle A, Morgan JE, Patridge TA, Jackson MJ (2004). Release of reactive oxygen and nitrogen species from contracting skeletal muscle cells. Free Radic.Biol Med, 37(7), 1064 - 1072.
    • Collins CA, Heslop L, Zammit PS, Olsen I, Partridge TA (2004). Identification of distinct stem cell subpopulations in the adult satellite cell compartment. Neuromuscular Disorders, 14(8-9), 614 - 614.
    • Zammit PS, Carvajal JJ, Golding JP, Morgan JE, Summerbell D, Zolnerciks J, Partridge TA, Rigby PW, Beauchamp JR (2004). Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements. Dev Biol, 273(2), 454 - 465.
    • Weir AP, Morgan JE, Davies KE (2004). A-utrophin up-regulation in mdx skeletal muscle is independent of regeneration. Neuromuscul.Disord, 14(1), 19 - 23.
    • Brimah K, Ehrhardt J, Mouly V, Butler-Browne GS, Partridge TA, Morgan JE (2004). Human muscle precursor cell regeneration in the mouse host is enhanced by growth factors. Hum Gene Ther, 15(11), 1109 - 1124.
    • Cousins JC, Woodward KJ, Gross JG, Partridge TA, Morgan JE (2004). Regeneration of skeletal muscle from transplanted immortalised myoblasts is oligoclonal. Journal of Cell Science, 117(Pt 15), 3259 - 3269. doi:10.1242/jcs.01161

    2003

    • Morgan JE, Partridge TA (2003). Muscle satellite cells. Int J Biochem.Cell Biol, 35(8), 1151 - 1156.
    • Collins CA, Morgan JE (2003). Duchenne's muscular dystrophy: animal models used to investigate pathogenesis and develop therapeutic strategies. Int J Exp Pathol, 84(4), 165 - 172.

    2002

    • Suzuki K, Murtuza B, Heslop L, Morgan JE, Smolenski RT, Suzuki N, Partridge TA, Yacoub MH (2002). Single fibers of skeletal muscle as a novel graft for cell transplantation to the heart. J Thorac Cardiovasc Surg, 123(5), 984 - 992.
    • Morgan JE, Gross JG, Pagel CN, Beauchamp JR, Fassati A, Thrasher AJ, Di Santo JP, Fisher IB, Shiwen X, Abraham DJ, Partridge TA (2002). Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site. The Journal of Cell Biology, 157(4), 693 - 702. doi:10.1083/jcb.200108047
    • Muntoni F, Fisher I, Morgan JE, Abraham D (2002). Steroids in Duchenne muscular dystrophy: from clinical trials to genomic research. Neuromuscul.Disord, 12 Suppl 1, S162 - S165.

    2001

    • Fisher I, Morgan J, Abraham D, Brittan H, Dunn M, Muntoni F (2001). Glucocorticoid-induced changes in the gene expression of dystrophic mouse muscle. Neuromuscular Disorders, 11(6-7), 663 - 663.
    • Mann CJ, Honeyman K, Cheng AJ, Ly T, Lloyd F, Fletcher S, Morgan JE, Partridge TA, Wilton SD (2001). Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse. Proc.Natl.Acad Sci U.S.A, 98(1), 42 - 47.
    • Cooper RN, Irintchev A, Di Santo JP, Zweyer M, Morgan JE, Partridge TA, Butler-Browne GS, Mouly V, Wernig A (2001). A new immunodeficient mouse model for human myoblast transplantation. Hum Gene Ther, 12(7), 823 - 831.

    2000

    • Pagel CN, Morgan JE, Gross JG, Partridge TA (2000). Thymic myoid cells as a source of cells for myoblast transfer. Cell Transplant., 9(4), 531 - 538.
    • Heslop L, Morgan JE, Partridge TA (2000). Evidence for a myogenic stem cell that is exhausted in dystrophic muscle. J.Cell Sci., 113 ( Pt 12), 2299 - 2308.

    1999

    • Bou-Gharios G, Wells DJ, Lu QL, Morgan JE, Partridge T (1999). Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast. Gene Ther., 6(6), 1021 - 1029.
    • Blaveri K, Heslop L, Yu DS, Rosenblatt JD, Gross JG, Partridge TA, Morgan JE (1999). Patterns of repair of dystrophic mouse muscle: studies on isolated fibers. Dev.Dyn., 216(3), 244 - 256.
    • Gross JG, Bou-Gharios G, Morgan JE (1999). Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery. Cell Tissue Res., 298(2), 371 - 375.
    • Harris JM, Morgan JE, Rosenblatt JD, Peckham M, Edwards YH, Partridge TA, Porter AGC (1999). Forced MyHCIIB expression following targeted genetic manipulation of conditionally immortalized muscle precursor cells. Experimental Cell Research, 253(2), 523 - 532.
    • Gross JG, Morgan JE (1999). Muscle precursor cells injected into irradiated mdx mouse muscle persist after serial injury. Muscle Nerve, 22(2), 174 - 185.
    • Ationu A, Humphries A, Lalloz MR, Arya R, Wild B, Warrilow J, Morgan J, Bellingham AJ, Layton DM (1999). Reversal of metabolic block in glycolysis by enzyme replacement in triosephosphate isomerase-deficient cells. Blood, 94(9), 3193 - 3198.
    • Beauchamp JR, Morgan JE, Pagel CN, Partridge TA (1999). Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source. J.Cell Biol., 144(6), 1113 - 1122.

    1998

    • Floyd SS, Jr C, P R O, M R K, S D, C S Y, J H, S D B, L M, J M, M S F, G W E, M H, J (1998). Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles. Gene Ther., 5(1), 19 - 30.
    • Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling D (1998). Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J., 17(6), 1688 - 1699.

    1997

    • Feero WG, Li S, Rosenblatt JD, Sirianni N, Morgan JE, Partridge TA, Huang L, Hoffman EP (1997). Selection and use of ligands for receptor-mediated gene delivery to myogenic cells. Gene Ther., 4(7), 664 - 674.
    • Partridge T, Beauchamp J, Morgan J, Tremblay JP, Huard J, Watt D, Wernig A, Irintchev A, Grounds M, Springer ML, Bartlett RJ, Mendell J, Vilquin JT, Bower JJ (1997). Meeting of the Cell Transplantation Society in Miami. Cell Transplant., 6(2), 195 - 198.

    1996

    • Morgan JE, Fletcher RM, Partridge TA (1996). Yields of muscle from myogenic cells implanted into young and old mdx hosts. Muscle Nerve, 19(2), 132 - 139.

    1995

    • Pagel CN, Morgan JE (1995). Myoblast transfer and gene therapy in muscular dystrophies. Microsc.Res.Tech., 30(6), 469 - 479.

    1994

    • Morgan JE, Beauchamp JR, Pagel CN, Peckham M, Ataliotis P, Jat PS, Noble MD, Farmer K, Partridge TA (1994). Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: a model system for the derivation of tissue-specific and mutation-specific cell lines. Dev.Biol., 162(2), 486 - 498.

    1993

    • Morgan JE, Pagel CN, Sherratt T, Partridge TA (1993). Long-term persistence and migration of myogenic cells injected into pre-irradiated muscles of mdx mice. J.Neurol.Sci., 115(2), 191 - 200.
    • McGeachie JK, Grounds MD, Partridge TA, Morgan JE (1993). Age-related changes in replication of myogenic cells in mdx mice: quantitative autoradiographic studies. J.Neurol.Sci., 119(2), 169 - 179.

    1992

    • Morgan JE, Partridge TA (1992). Cell transplantation and gene therapy in muscular dystrophy. Bioessays, 14(9), 641 - 645.
    • Moens P, Partridge TA, Morgan JE, Beckers-Bleukx G, Marechal G (1992). Regeneration after free muscle grafting in normal and dystrophic (mdx) mice. J.Neurol.Sci., 111(2), 209 - 213.
    • Morgan JE, Moore SE, Walsh FS, Partridge TA (1992). Formation of skeletal muscle in vivo from the mouse C2 cell line. J.Cell Sci., 102 ( Pt 4), 779 - 787.

    1991

    • Watt DJ, Morgan JE, Partridge TA (1991). Allografts of muscle precursor cells persist in the non-tolerized host. Neuromuscul.Disord., 1(5), 345 - 355.
    • Coulton G, Skynner M, Pagel C, Morgan J, Partridge T (1991). In situ hybridisation of a Y chromosome-specific probe to male myoblasts after implantation into female skeletal muscle. Biochem.Soc.Trans., 19(2), 195S - .
    • Pagel C, Watt D, Naudeer S, Partridge T, Morgan J (1991). The change in dystrophin phenotype in heterozygous mdx mice. J.Neuropathol.Exp.Neurol., 50(3), 278 - 280.

    1990

    • Hoffman EP, Morgan JE, Watkins SC, Partridge TA (1990). Somatic reversion/suppression of the mouse mdx phenotype in vivo. J.Neurol.Sci., 99(1), 9 - 25.
    • Morgan JE, Hoffman EP, Partridge TA (1990). Normal myogenic cells from newborn mice restore normal histology to degenerating muscles of the mdx mouse. J.Cell Biol., 111(6 Pt 1), 2437 - 2449.
    • Carter ND, Morgan JE, Monaco AP, Schwartz MS, Jeffery S (1990). Dystrophin expression and genotypic analysis of two cases of benign X linked myopathy (McLeod's syndrome). J.Med.Genet., 27(6), 345 - 347.

    1989

    • Morgan JE, Coulton GR, Partridge TA (1989). Mdx muscle grafts retain the mdx phenotype in normal hosts. Muscle Nerve, 12(5), 401 - 409.
    • Partridge TA, Morgan JE, Coulton GR, Hoffman EP, Kunkel LM (1989). Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts. Nature, 337(6203), 176 - 179.

    1988

    • Morgan JE (1988). Myogenicity in vitro and in vivo of mouse muscle cells separated on discontinuous Percoll gradients. J.Neurol.Sci., 85(2), 197 - 207.
    • Coulton GR, Morgan JE, Partridge TA, Sloper JC (1988). The mdx mouse skeletal muscle myopathy: I. A histological, morphometric and biochemical investigation. Neuropathol.Appl.Neurobiol., 14(1), 53 - 70.
    • Morgan JE, Watt DJ, Sloper JC, Partridge TA (1988). Partial correction of an inherited biochemical defect of skeletal muscle by grafts of normal muscle precursor cells. J.Neurol.Sci., 86(2-3), 137 - 147.
    • Morgan JE (1988). Phosphorylase kinase activities in damaged mouse skeletal muscles. J.Neurol.Sci., 86(2-3), 149 - 158.
    • Cavanna JS, Coulton G, Morgan JE, Brockdorff N, Forrest SM, Davies KE, Brown SD (1988). Molecular and genetic mapping of the mouse mdx locus. Genomics, 3(4), 337 - 341.
    • Coulton GR, Curtin NA, Morgan JE, Partridge TA (1988). The mdx mouse skeletal muscle myopathy: II. Contractile properties. Neuropathol.Appl.Neurobiol., 14(4), 299 - 314.

    1987

    • Morgan JE, Coulton GR, Partridge TA (1987). Muscle precursor cells invade and repopulate freeze-killed muscles. J.Muscle Res.Cell Motil., 8(5), 386 - 396.
    • Watt DJ, Morgan JE, Clifford MA, Partridge TA (1987). The movement of muscle precursor cells between adjacent regenerating muscles in the mouse. Anat.Embryol.(Berl), 175(4), 527 - 536.

    1984

    • Watt DJ, Morgan JE, Partridge TA (1984). Use of mononuclear precursor cells to insert allogeneic genes into growing mouse muscles. Muscle Nerve, 7(9), 741 - 750.
    • Watt DJ, Morgan JE, Partridge TA (1984). Long term survival of allografted muscle precursor cells following a limited period of treatment with cyclosporin A. Clin.Exp.Immunol., 55(2), 419 - 426.

    1982

    • Watt DJ, Lambert K, Morgan JE, Partridge TA, Sloper JC (1982). Incorporation of donor muscle precursor cells into an area of muscle regeneration in the host mouse. J.Neurol.Sci., 57(2-3), 319 - 331.