Prof John Collinge

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Personal Profile

Name: John Collinge Email: j.collinge@ucl.ac.uk
Title: Prof Tel: 020 7837 4888
Department: Neurodegenerative Diseases Fax:
Position: Professor of Neurology Address: National Hospital for Neurology & Neurosurgery, UCL, Queen Square, London , WC1N 3BG
Research Domain: Basic Life Sciences, Neuroscience Web Page: Personal Web Page

Profile

Research Description

The Department of Neurodegenerative Disease’s research portfolio encompasses prion diseases (predominantly within the embedded MRC Prion Unit), Alzheimer’s disease and related disorders, Huntington’s disease, motor neurone disease and frontotemporal dementia and studies of the pathways of cellular senescence. The research philosophy is to combine basic and clinical translational research; many of the key contributions towards understanding the basic biology of these diseases have come from clinical and neuropathological observations, and efficient translation of basic laboratory research to the clinic is essential to provide benefits for patients at the earliest opportunity.

The MRC Prion Unit was established in 1998 and is located at the UCL Institute of Neurology where it is closely integrated with the University Department of Neurodegenerative Disease. The Unit was formed to provide a national centre of excellence with all necessary facilities to pursue a major long-term research strategy in prion and related diseases. 

Prions, unlike other infectious agents or germs, appear to lack their own genes and consist of aggregated misshapen forms of one of the body’s own proteins, the prion protein or PrP. Despite lacking genes, prions can exist as distinct strains with quite different properties. These unique features have wide implications in biology and evolution, and prions and prion diseases are of intense international research interest. However, in addition to the importance of this basic science, the Unit’s mission is also to tackle key public health issues posed by bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD).

It is becoming increasingly clear that other much commoner degenerative brain diseases, such as Alzheimer’s and Parkinson’s disease, also involve accumulation of rogue or abnormal forms of one or more of the body’s proteins resulting in damage to brain cells. Prion diseases, in addition to their intrinsic interest and importance, can be considered a paradigm for these other “protein misfolding” diseases. 

Our research programmes are highly multidisciplinary and focus both on areas of public health concern and a long-term approach to the understanding of prion disease. They include studies of molecular structure, genetics, biochemistry, immunology, cell and animal models, and clinical research - including treatment trials. Two major programmes to develop novel therapies are underway.


Research Activities

Cellular mechanisms underlying neurodegeneration

Neurodegenerative Disease

Neurological disease

Education Description

UCL Collaborators

Prof Parmjit Jat; Prof John Hardy; Prof Henry Houlden; Prof Andrew Lees; Prof Ivan Gout; Dr Simon Mead; Prof Kailash Bhatia; Prof Sarah Tabrizi; Dr Peter-Christian Kloehn; Dr Marc Soutar; Prof Nicholas Wood; Prof Martin Rossor; Dr Helene Plun-Favreau; Dr Stephanie Schorge; Prof Mike O'hare

External Collaborators

Publications

    2014

    • Mirabile I, Jat PS, Brandner S, Collinge J (2014). Identification of clinical target areas in the brainstem of prion infected mice.. Neuropathol Appl Neurobiol, , - . doi:10.1111/nan.12189
    • Jackson GS, Burk-Rafel J, Edgeworth JA, Sicilia A, Abdilahi S, Korteweg J, Mackey J, Thomas C, Wang G, Mead S, Collinge J (2014). A highly specific blood test for vCJD.. Blood, 123(3), 452 - 453. doi:10.1182/blood-2013-11-539239
    • Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan H-M, Cai Y, Bloom GS, Jat P, Collinge J, Kloehn P-C (2014). Cellular prion replication is controlled by expression of extracellular matrix proteins. PRION, 8, 21 - 21.
    • West BT, Collinge J, Kloehn P-C (2014). A loss of gene function approach to better understand the role of cholesterol in prion replication. PRION, 8, 29 - 29.
    • Slattery CF, Beck JA, Harper L, Adamson G, Abdi Z, Uphill J, Campbell T, Druyeh R, Mahoney CJ, Rohrer JD, Kenny J, Lowe J, Leung KK, Barnes J, Clegg SL, Blair M, Nicholas JM, Guerreiro RJ, Rowe JB, Ponto C, Zerr I, Kretzschmar H, Gambetti P, Crutch SJ, Warren JD, Rossor MN, Fox NC, Collinge J, Schott JM, Mead S (2014). R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.. Alzheimers Dement, , - . doi:10.1016/j.jalz.2014.05.1751
    • Slattery C, Beck J, Harper L, Adamson G, Abdi Z, Uphill J, Campbell T, Druyeh R, Mahoney C, Rohrer J, Kenny J, Lowe J, Leung K, Barnes J, Clegg S, Blair M, Nicholas J, Guerreiro R, Rowe J, Ponto C, Zerr I, Kretzschmar H, Gambetti P, Crutch S, Warren J, Rossor M, Fox N, Collinge J, Schott J, Mead S (2014). Trem2 variants increase risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.. J Neurol Neurosurg Psychiatry, 85(8), e3 - . doi:10.1136/jnnp-2014-308883.7
    • Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, Hernández I, Ruiz A, Boada M, Borroni B, Padovani A, Cruchaga C, Cairns NJ, Benussi L, Binetti G, Ghidoni R, Forloni G, Galimberti D, Fenoglio C, Serpente M, Scarpini E, Clarimón J, Lleó A, Blesa R, Waldö ML, Nilsson K, Nilsson C, Mackenzie IR, Hsiung GY, Mann DM, Grafman J, Morris CM, Attems J, Griffiths TD, McKeith IG, Thomas AJ, Pietrini P, Huey ED, Wassermann EM, Baborie A, Jaros E, Tierney MC, Pastor P, Razquin C, Ortega-Cubero S, Alonso E, Perneczky R, Diehl-Schmid J, Alexopoulos P, Kurz A, Rainero I, Rubino E, Pinessi L, Rogaeva E, St George-Hyslop P, Rossi G, Tagliavini F, Giaccone G, Rowe JB, Schlachetzki JC, Uphill J, Collinge J, Mead S, Danek A, Van Deerlin VM, Grossman M, Trojanowski JQ, van der Zee J, Deschamps W, Van Langenhove T, Cruts M, Van Broeckhoven C, Cappa SF, Le Ber I, Hannequin D, Golfier V, Vercelletto M, Brice A, Nacmias B, Sorbi S, Bagnoli S, Piaceri I, Nielsen JE, Hjermind LE, Riemenschneider M, Mayhaus M, Ibach B, Gasparoni G, Pichler S, Gu W, Rossor MN, Fox NC, Warren JD, Spillantini MG, Morris HR, Rizzu P, Heutink P, Snowden JS, Rollinson S, Richardson A, Gerhard A, Bruni AC, Maletta R, Frangipane F, Cupidi C, Bernardi L, Anfossi M, Gallo M, Conidi ME, Smirne N, Rademakers R, Baker M, Dickson DW, Graff-Radford NR, Petersen RC, Knopman D, Josephs KA, Boeve BF, Parisi JE, Seeley WW, Miller BL, Karydas AM, Rosen H, van Swieten JC, Dopper EG, Seelaar H, Pijnenburg YA, Scheltens P, Logroscino G, Capozzo R, Novelli V, Puca AA, Franceschi M, Postiglione A, Milan G, Sorrentino P, Kristiansen M, Chiang HH, Graff C, Pasquier F, Rollin A, Deramecourt V, Lebert F, Kapogiannis D, Ferrucci L, Pickering-Brown S, Singleton AB, Hardy J, Momeni P (2014). Frontotemporal dementia and its subtypes: a genome-wide association study.. Lancet Neurol, 13(7), 686 - 699. doi:10.1016/S1474-4422(14)70065-1
    • Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M, the United Kingdom Brain Expression Consortium , Johnson AD, Ruiz A, Bihoreau MT, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Hernández I, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, George-Hyslop PS, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Scarpini E, Bonuccelli U, Mancuso M, Siciliano G, Moebus S, Mecocci P, Zompo MD, Maier W, Hampel H, Pilotto A, Frank-García A, Panza F, Solfrizzi V, Caffarra P, Nacmias B, Perry W, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Haines JL, Lathrop M, Pericak-Vance MA, Launer LJ, Van Broeckhoven C, Farrer LA, van Duijn CM, Ramirez A, Seshadri S, Schellenberg GD, Amouyel P, Williams J (2014). Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease.. PLoS One, 9(6), e94661 - . doi:10.1371/journal.pone.0094661
    • Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J (2014). Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease Aβ Synaptotoxicity.. J Neurosci, 34(18), 6140 - 6145. doi:10.1523/JNEUROSCI.3526-13.2014
    • Grizenkova J, Akhtar S, Brandner S, Collinge J, Lloyd SE (2014). Microglial Cx3cr1 knockout reduces prion disease incubation time in mice.. BMC Neurosci, 15, 44 - . doi:10.1186/1471-2202-15-44
    • Thompson A, MacKay A, Rudge P, Lukic A, Porter M-C, Lowe J, Collinge J, Mead S (2014). Behavioural and Psychiatric Symptoms in Prion Disease. American Journal of Psychiatry, 171(3), 265 - 274. doi:10.1176/appi.ajp.2013.12111460
    • Beck J, Adamson G, Campbell T, Uphill J, Poulter M, Collinge J, Mead S, Pittman A, Houlden H, Shoai M, Hardy J, Kenny J, Rohrer JD, Mummery CJ, Warren JD, Schott JM, Fox NC, Rossor MN, de Silva R (2014). Validation of next-generation sequencing technologies in genetic diagnosis of dementia. Neurobiology of Aging, 35(1), 261 - 265. doi:10.1016/j.neurobiolaging.2013.07.017
    • Mead S, Wadsworth JD, Porter MC, Linehan JM, Pietkiewicz W, Jackson GS, Brandner S, Collinge J (2014). Variant Creutzfeldt-Jakob Disease With Extremely Low Lymphoreticular Deposition of Prion Protein.. JAMA Neurol, , - . doi:10.1001/jamaneurol.2013.5378
    • Brown CA, Schmidt C, Poulter M, Hummerich H, Kloehn P-C, Jat P, Mead S, Collinge J, Lloyd SE (2014). In vitro screen of prion disease susceptibility genes using the scrapie cell assay. HUMAN MOLECULAR GENETICS, 23(19), 5102 - 5108. doi:10.1093/hmg/ddu233
    • Minikel EV, Zerr I, Collins SJ, Ponto C, Boyd A, Klug G, Karch A, Kenny J, Collinge J, Takada LT, Forner S, Fong JC, Mead S, Geschwind MD (2014). Ascertainment bias causes false signal of anticipation in genetic prion disease.. Am J Hum Genet, 95(4), 371 - 382. doi:10.1016/j.ajhg.2014.09.003
    • Mead S, Burnell M, Lowe J, Lukic A, Porter M-C, Thompson A, Carswell C, Kaski D, Kenny J, Bjurgsrom N, Gorham M, Druyeh R, Wadsworth J, Brandner S, Hyare H, Walker AS, Rudge P, Collinge J (2014). Stratified medicine approach in sporadic Creutzfeldt-Jakob disease greatly increases power in simulated clinical trials. PRION, 8, 10 - 10.
    • Wright D, Purro SA, Nicoll AJ, Collinge J (2014). PrP-A beta binding as a quality control for ADDL preparations. PRION, 8, 111 - 111.
    • Jackson GS, Burk-Rafel J, Mead S, Collinge J (2014). Blood Test for Variant Creutzfeldt-Jakob Disease-Reply.. JAMA Neurol, 71(8), 1054 - 1055. doi:10.1001/jamaneurol.2014.1539
    • Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR (2014). N-terminal Domain of Prion Protein Directs its Oligomeric Association.. J Biol Chem, , - . doi:10.1074/jbc.M114.566588
    • Sandberg MK, Al-Doujaily H, Sharps B, De Oliveira MW, Schmidt C, Richard-Londt A, Lyall S, Linehan JM, Brandner S, Wadsworth JD, Clarke AR, Collinge J (2014). Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.. Nat Commun, 5, 4347 - . doi:10.1038/ncomms5347
    • Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan HM, Cai Y, Bloom GS, Jat P, Collinge J, Klöhn PC (2014). Identification of a gene regulatory network associated with prion replication.. EMBO J, , - . doi:10.15252/embj.201387150
    • Brown CA, Schmidt C, Poulter M, Hummerich H, Klöhn PC, Jat P, Mead S, Collinge J, Lloyd SE (2014). In-vitro screen of prion disease susceptibility genes using the scrapie cell assay.. Hum Mol Genet, , - . doi:10.1093/hmg/ddu233
    • Owen J, Beck J, Campbell T, Adamson G, Gorham M, Thompson A, Smithson S, Rosser E, Rudge P, Collinge J, Mead S (2014). Predictive testing for inherited prion disease: report of 22 years experience.. Eur J Hum Genet, , - . doi:10.1038/ejhg.2014.42
    • Thompson A, Mackay A, Rudge P, Lukic A, Porter MC, Lowe J, Collinge J, Mead S (2014). Behavioral and psychiatric symptoms in prion disease.. Am J Psychiatry, 171(3), 265 - 274. doi:10.1176/appi.ajp.2013.12111460
    • Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ (2014). mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo.. Nat Commun, 5, 3374 - . doi:10.1038/ncomms4374
    • Jackson GS, Burk-Rafel J, Edgeworth JA, Sicilia A, Abdilahi S, Korteweg J, Mackey J, Thomas C, Wang G, Schott JM, Mummery C, Chinnery PF, Mead S, Collinge J (2014). Population Screening for Variant Creutzfeldt-Jakob Disease Using a Novel Blood Test: Diagnostic Accuracy and Feasibility Study.. JAMA Neurol, , - . doi:10.1001/jamaneurol.2013.6001
    • Porter M-C, De Vita E, Simpson I, Ourselin S, Lowe J, Franko E, Bjurstrom N, Rudge P, Mead S, Collinge J, Thornton J, Hyare H (2014). Multi-parameter MRI analysis in the national prion monitoring cohort. PRION, 8, 111 - 112.

    2013

    • Begum R (2013). Functional analysis of Hectd2: a prion disease modifier associated with incubation time.
    • Akhtar S, Grizenkova J, Wenborn A, Hummerich H, Fernandez de Marco M, Brandner S, Collinge J, Lloyd SE (2013). Sod1 deficiency reduces incubation time in mouse models of prion disease.. PLoS One, 8(1), e54454 - . doi:10.1371/journal.pone.0054454
    • Reiniger L, Mirabile I, Lukic A, Wadsworth JD, Linehan JM, Groves M, Lowe J, Druyeh R, Rudge P, Collinge J, Mead S, Brandner S (2013). Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases.. Acta Neuropathol Commun, 1(1), 8 - . doi:10.1186/2051-5960-1-8
    • Mead S, Gandhi S, Beck J, Caine D, Gallujipali D, Carswell C, Hyare H, Joiner S, Ayling H, Lashley T, Linehan JM, Al-Doujaily H, Sharps B, Revesz T, Sandberg M, Reilly M, Koltzenburg M, Forbes A, Rudge P, Brandner S, Warren JD, Wadsworth JDF, Wood NW, Holton JL, Collinge J (2013). A Novel Prion Disease Presenting with Diarrhea and Autonomic Neuropathy. New England Journal of Medicine, , - .
    • Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, European Alzheimer's Disease Initiative (EADI) , Genetic and Environmental Risk in Alzheimer's Disease (GERAD) , Alzheimer's Disease Genetic Consortium (ADGC) , Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) , Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P (2013). Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.. Nat Genet, , - . doi:10.1038/ng.2802
    • Asante EA, Linehan JM, Smidak M, Tomlinson A, Grimshaw A, Jeelani A, Jakubcova T, Hamdan S, Powell C, Brandner S, Wadsworth JD, Collinge J (2013). Inherited Prion Disease A117V Is Not Simply a Proteinopathy but Produces Prions Transmissible to Transgenic Mice Expressing Homologous Prion Protein.. PLoS Pathog, 9(9), e1003643 - . doi:10.1371/journal.ppat.1003643
    • Goold R, McKinnon C, Rabbanian S, Collinge J, Schiavo G, Tabrizi SJ (2013). Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane. JOURNAL OF CELL SCIENCE, 126(16), 3552 - 3562. doi:10.1242/jcs.120477
    • Fratta P, Poulter M, Lashley T, Rohrer JD, Polke JM, Beck J, Ryan N, Hensman D, Mizielinska S, Waite AJ, Lai MC, Gendron TF, Petrucelli L, Fisher EM, Revesz T, Warren JD, Collinge J, Isaacs AM, Mead S (2013). Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia.. Acta Neuropathol, , - . doi:10.1007/s00401-013-1147-0
    • Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2013). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.. Nat Genet, 45(6), 712 - . doi:10.1038/ng0613-712a
    • Reiniger L, Mirabile I, Lukic A, Linehan J, Groves M, Rudge P, Collinge J, Mead S, Brandner S (2013). Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases.
    • Thompson AG, Lowe J, Fox Z, Lukic A, Porter MC, Ford L, Gorham M, Gopalakrishnan GS, Rudge P, Walker AS, Collinge J, Mead S (2013). The Medical Research Council prion disease rating scale: a new outcome measure for prion disease therapeutic trials developed and validated using systematic observational studies.. Brain, 136(Pt 4), 1116 - 1127. doi:10.1093/brain/awt048
    • De Vita E, Ridgway GR, Scahill RI, Caine D, Rudge P, Yousry TA, Mead S, Collinge J, Jäger HR, Thornton JS, Hyare H (2013). Multiparameter MR imaging in the 6-OPRI variant of inherited prion disease.. AJNR Am J Neuroradiol, 34(9), 1723 - 1730. doi:10.3174/ajnr.A3504
    • Lloyd SE, Mead S, Collinge J (2013). Genetics of prion diseases.. Curr Opin Genet Dev, 23(3), 345 - 351. doi:10.1016/j.gde.2013.02.012
    • Beck J, Poulter M, Hensman D, Rohrer JD, Mahoney CJ, Adamson G, Campbell T, Uphill J, Borg A, Fratta P, Orrell RW, Malaspina A, Rowe J, Brown J, Hodges J, Sidle K, Polke JM, Houlden H, Schott JM, Fox NC, Rossor MN, Tabrizi SJ, Isaacs AM, Hardy J, Warren JD, Collinge J, Mead S (2013). Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.. Am J Hum Genet, 92(3), 345 - 353. doi:10.1016/j.ajhg.2013.01.011
    • Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J, Alzheimer Genetic Analysis G (2013). TREM2 variants in Alzheimer's disease. N Engl J Med, 368, 117 - 127. doi:10.1056/NEJMoa1211851
    • Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J, Alzheimer Genetic Analysis Group (2013). TREM2 variants in Alzheimer's disease.. N Engl J Med, 368(2), 117 - 127. doi:10.1056/NEJMoa1211851
    • Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J (2013). Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.. Nat Commun, 4, 2416 - . doi:10.1038/ncomms3416
    • Jackson GS, D-GEN LTD, Collinge J, Edgeworth JA (2013). Assay for Prions.
    • Wadsworth JD, Joiner S, Linehan JM, Balkema-Buschmann A, Spiropoulos J, Simmons MM, Griffiths PC, Groschup MH, Hope J, Brandner S, Asante EA, Collinge J (2013). Atypical scrapie prions from sheep and lack of disease in transgenic mice overexpressing human prion protein.. Emerg Infect Dis, 19(11), 1731 - 1739. doi:10.3201/eid1911.121341
    • Klöhn PC, Castro-Seoane R, Collinge J (2013). Exosome release from infected dendritic cells: A clue for a fast spread of prions in the periphery?. J Infect, , - . doi:10.1016/j.jinf.2013.07.024
    • Angus-Leppan H, Rudge P, Mead S, Collinge J, Vincent A (2013). Autoantibodies in Sporadic Creutzfeldt-Jakob Disease.. JAMA Neurol, , 1 - 4. doi:10.1001/jamaneurol.2013.2077
    • Angus-Leppan H, Rudge P, Mead S, Collinge J, Vincent A (2013). Creutzfeld-jakob disease-reply.. JAMA Neurol, 70(12), 1589 - . doi:10.1001/jamaneurol.2013.4777

    2012

    • Carswell C, Thompson A, Lukic A, Stevens J, Rudge P, Mead S, Collinge J, Hyare H (2012). MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease.. BMC Neurol, 12, 153 - . doi:10.1186/1471-2377-12-153
    • Hyare H, Ramlackhansingh A, Gelosa G, Edison P, Rudge P, Brandner S, Brooks DJ, Collinge J, Mead S (2012). 11C-PiB PET does not detect PrP-amyloid in prion disease patients including variant Creutzfeldt-Jakob disease.. J Neurol Neurosurg Psychiatry, 83(3), 340 - 341. doi:10.1136/jnnp.2010.233692
    • Carswell C, Rañopa M, Pal S, Macfarlane R, Siddique D, Thomas D, Webb T, Wroe S, Walker S, Darbyshire J, Collinge J, Mead S, Rudge P (2012). Video Rating in Neurodegenerative Disease Clinical Trials: The Experience of PRION-1.. Dement Geriatr Cogn Dis Extra, 2(1), 286 - 297.
    • Kloehn P, Castro-Seoane R, Hummerich H, Sweeting T, Tattum H, Linehan J, de Marco MF, Brandner S, Collinge J (2012). Plasmacytoid dendritic cells sequester high prion titers at early stages of prion infection. PRION, 6, 7 - 7.
    • Porter MC, Hyare H, De Vita E, Thompson A, Lukic A, Yousry T, Rudge P, Mead S, Collinge J, Thornton J (2012). VOXELWISE ANALYSIS OF CEREBRAL DIFFUSION TENSOR IMAGING IN PRION DISEASES. doi:10.1136/jnnp-2011-301993.64
    • Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, O'Malley C, Farmer M, Parkinson N, Fisher EM, Asante EA, Brandner S, Collinge J, Isaacs AM (2012). Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.. Brain, 135(Pt 3), 819 - 832. doi:10.1093/brain/aws006
    • Mahoney CJ, Beck J, Rohrer JD, Lashley T, Mok K, Shakespeare T, Yeatman T, Warrington EK, Schott JM, Fox NC, Rossor MN, Hardy J, Collinge J, Revesz T, Mead S, Warren JD (2012). Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features.. Brain, 135(Pt 3), 736 - 750. doi:10.1093/brain/awr361
    • Klöhn PC, Farmer M, Linehan JM, O'Malley C, Fernandez de Marco M, Taylor W, Farrow M, Khalili-Shirazi A, Brandner S, Collinge J (2012). PrP antibodies do not trigger mouse hippocampal neuron apoptosis.. Science, 335(6064), 52 - . doi:10.1126/science.1215579
    • McNaughton D, Knight W, Guerreiro R, Ryan N, Lowe J, Poulter M, Nicholl DJ, Hardy J, Revesz T, Lowe J, Rossor M, Collinge J, Mead S (2012). Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series.. Neurobiol Aging, 33(2), 426.e13 - 426.e21. doi:10.1016/j.neurobiolaging.2010.10.010
    • Collinge J (2012). Prion propagation and its wider implications. PRION, 6, 1 - 1.
    • Beck J, Collinge J, Mead S (2012). Prion protein gene M232R variation is probably an uncommon polymorphism rather than a pathogenic mutation.. Brain, 135(Pt 2), e209 - . doi:10.1093/brain/awr294
    • Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante EA, Wenborn A, Fizet J, Poulter M, Wiseman FK, Fisher EM, Tybulewicz VL, Brandner S, Collinge J, Lloyd SE (2012). Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.. Proc Natl Acad Sci U S A, 109(34), 13722 - 13727. doi:10.1073/pnas.1208917109
    • Quarterman E, Pannell M, Adams N, Farrow M, Collinge J (2012). High throughput screen of pharmacologically active compounds using chronically infected neuroblastoma (PK1) cells. PRION, 6, 102 - 102.
    • Hyare H, Ramlackhansingh A, Gelosa G, Edison P, Rudge P, Brandner S, Brooks DJ, Collinge J, Mead S (2012). C-11-PiB PET does not detect PrP-amyloid in prion disease patients including variant Creutzfeldt-Jakob disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 83(3), 340 - 341.
    • Castro-Seoane R, Hummerich H, Sweeting T, Tattum MH, Linehan JM, Fernandez de Marco M, Brandner S, Collinge J, Klöhn PC (2012). Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.. PLoS Pathog, 8(2), e1002538 - . doi:10.1371/journal.ppat.1002538
    • Collinge J (2012). Cell biology. The risk of prion zoonoses.. Science, 335(6067), 411 - 413. doi:10.1126/science.1218167
    • Mead S, Uphill J, Beck J, Poulter M, Campbell T, Lowe J, Adamson G, Hummerich H, Klopp N, Rückert IM, Wichmann HE, Azazi D, Plagnol V, Pako WH, Whitfield J, Alpers MP, Whittaker J, Balding DJ, Zerr I, Kretzschmar H, Collinge J (2012). Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.. Hum Mol Genet, 21(8), 1897 - 1906. doi:10.1093/hmg/ddr607
    • Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Kölsch H, Heun R, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Davies G, Harris SE, Starr JM, Deary IJ, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Jones L, Holmans PA, O'Donovan MC, Owen MJ, Williams J (2012). The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease.. J Alzheimers Dis, 28(2), 377 - 387. doi:10.3233/JAD-2011-110824
    • Alner K, Hyare H, Mead S, Rudge P, Wroe S, Rohrer JD, Ridgway GR, Ourselin S, Clarkson M, Hunt H, Fox NC, Webb T, Collinge J, Cipolotti L (2012). Distinct neuropsychological profiles correspond to distribution of cortical thinning in inherited prion disease caused by insertional mutation.. J Neurol Neurosurg Psychiatry, 83(1), 109 - 114. doi:10.1136/jnnp-2011-300167
    • Mead S, Beck J, Poulter M, Rohrer J, Adamson G, Hensman D, Polke J, Campbell T, Uphill J, Borg A, Tabrizi S, Isaacs A, Hardy J, Warren J, Collinge J (2012). Large C9ORF72 hexanucleotide expansions arise spontaneously in the healthy population but can be distinguished from pathogenic mutations by Sothern Blotting.

    2011

    • Mead S, Ranopa M, Gopalakrishnan GS, Thompson AG, Rudge P, Wroe S, Kennedy A, Hudson F, MacKay A, Darbyshire JH, Collinge J, Walker AS (2011). PRION-1 scales analysis supports use of functional outcome measures in prion disease.. Neurology, 77(18), 1674 - 1683. doi:10.1212/WNL.0b013e3182364890
    • Reiniger L, Lukic A, Linehan J, Rudge P, Collinge J, Mead S, Brandner S (2011). Tau, prions and Aβ: the triad of neurodegeneration.. Acta Neuropathol, 121(1), 5 - 20. doi:10.1007/s00401-010-0691-0
    • Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ (2011). Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.. EMBO J, 30(15), 3065 - 3077. doi:10.1038/emboj.2011.224
    • Carswell C, Drynda R, Martins S, Clarke A, Brandner S, Mead S, Collinge J, Khalili-Shirazi A (2011). PAW35 Anti-prion protein monoclonal antibodies at low doses effectively treat prion disease in mice without side-effects (vol 81, pg e33, 2010). J NEUROL NEUROSUR PS, 82(7), 826 - 826. doi:10.1136/jnnp.2010.226340.63corr1
    • Lloyd S, Mead S, Collinge J (2011). Genetics of prion disease.. Top Curr Chem, 305, 1 - 22. doi:10.1007/128_2011_157
    • Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, Alzheimer's Disease Neuroimaging Initiative , van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S, CHARGE consortium , Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M, EADI1 consortium , Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J (2011). Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.. Nat Genet, 43(5), 429 - 435. doi:10.1038/ng.803
    • Rohrer JD, Warren JD, Reiman D, Uphill J, Beck J, Collinge J, Rossor MN, Isaacs AM, Mead S (2011). A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes.. J Neurol, 258(8), 1494 - 1496. doi:10.1007/s00415-011-5966-4
    • Goold R, Rabbanian S, Sutton L, Andre R, Arora P, Moonga J, Clarke AR, Schiavo G, Jat P, Collinge J, Tabrizi SJ (2011). Rapid cell-surface prion protein conversion revealed using a novel cell system. NAT COMMUN, 2, - . doi:10.1038/ncomms1282
    • Rollinson S, Rohrer JD, van der Zee J, Sleegers K, Mead S, Engelborghs S, Collinge J, De Deyn PP, Mann DM, Van Broeckhoven C, Pickering-Brown SM (2011). No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.. Neurobiol Aging, 32(4), 754 - 755. doi:10.1016/j.neurobiolaging.2009.04.009
    • Ratté S, Vreugdenhil M, Boult JK, Patel A, Asante EA, Collinge J, Jefferys JG (2011). Threshold for epileptiform activity is elevated in prion knockout mice.. Neuroscience, 179, 56 - 61. doi:10.1016/j.neuroscience.2011.01.053
    • Begum R, Lloyd S, Collinge J (2011). Functional analysis of a prion disease modifier linked to incubation time.
    • Akhtar S, Wenborn A, Brandner S, Collinge J, Lloyd SE (2011). Sex effects in mouse prion disease incubation time.. PLoS One, 6(12), e28741 - . doi:10.1371/journal.pone.0028741
    • Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J (2011). Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites.. Nat Commun, 2, 336 - . doi:10.1038/ncomms1341
    • Kaski DN, Pennington C, Beck J, Poulter M, Uphill J, Bishop MT, Linehan JM, O'Malley C, Wadsworth JD, Joiner S, Knight RS, Ironside JW, Brandner S, Collinge J, Mead S (2011). Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors.. Brain, 134(Pt 6), 1829 - 1838. doi:10.1093/brain/awr079
    • Wadsworth JD, Dalmau-Mena I, Joiner S, Linehan JM, O'Malley C, Powell C, Brandner S, Asante EA, Ironside JW, Hilton DA, Collinge J (2011). Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study.. J Pathol, 223(4), 511 - 518. doi:10.1002/path.2821
    • Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J (2011). Prion propagation and toxicity in vivo occur in two distinct mechanistic phases.. Nature, 470(7335), 540 - 542. doi:10.1038/nature09768
    • Edgeworth JA, Farmer M, Sicilia A, Tavares P, Beck J, Campbell T, Lowe J, Mead S, Rudge P, Collinge J, Jackson GS (2011). Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay.. Lancet, 377(9764), 487 - 493. doi:10.1016/S0140-6736(10)62308-2
    • Lukic A, Mead S, Rudge P, Collinge J (2011). Comment on validation of diagnostic criteria for variant Creutzfeldt-Jakob disease.. Ann Neurol, 69(1), 212 - . doi:10.1002/ana.22273
    • Wadsworth JDF, Collinge J (2011). Molecular pathology of human prion disease. ACTA NEUROPATHOL, 121(1), 69 - 77. doi:10.1007/s00401-010-0735-5
    • Reiniger L, Lukic A, Linehan J, Rudge P, Collinge J, Mead S, Brandner S (2011). Prion protein-induced tau phosphorylation: insight into a universal mechanism triggered by cerebral amyloid.
    • Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Peters O, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J (2011). Correction: genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.. PLoS One, 6(2), - . doi:10.1371/annotation/a0bb886d-d345-4a20-a82e-adce9b047798
    • Edgeworth JA, Sicilia A, Linehan J, Brandner S, Jackson GS, Collinge J (2011). A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding Assay.. J Gen Virol, 92(Pt 3), 718 - 726. doi:10.1099/vir.0.027201-0
    • Stevens JC, Beck J, Lukic A, Ryan N, Abbs S, Collinge J, Fox NC, Mead S (2011). Familial Alzheimer's disease and inherited prion disease in the UK are poorly ascertained.. J Neurol Neurosurg Psychiatry, 82(9), 1054 - 1057. doi:10.1136/jnnp.2009.199653
    • Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, Jones N, Abraham R, Ivanov D, Pahwa JS, Moskvina V, Dowzell K, Thomas C, Stretton A, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuiness B, Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Livingston G, Bass NJ, Gurling H, McQuillin A, Jones L, Holmans PA, O'Donovan M, Owen MJ, Williams J (2011). No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.. Am J Med Genet B Neuropsychiatr Genet, 156B(7), 764 - 771. doi:10.1002/ajmg.b.31216

    2010

    • Mead S, Linehan J, Beck J, Caine D, Gandhi S, Wadsworth JD, Joiner S, Gallujipali D, Hyare H, Lees A, Holton J, Sandberg M, Revesz T, Carswell C, Warren JD, Collinge J, Wood N (2010). PATU2 Novel truncation mutation of PRNP causes chronic diarrhoea, sensory neuropathy and autonomic failure associated with prion protein deposition in the cerebral blood vessels and small bowel.. J Neurol Neurosurg Psychiatry, 81(11), e24 - . doi:10.1136/jnnp.2010.226340.31
    • Grizenkova J, Akhtar S, Collinge J, Lloyd SE (2010). The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.. PLoS One, 5(12), e15019 - . doi:10.1371/journal.pone.0015019
    • Siddique D, Hyare H, Wroe S, Webb T, Macfarlane R, Rudge P, Collinge J, Powell C, Brandner S, So PW, Walker S, Mead S, Yousry T, Thornton JS (2010). Magnetization transfer ratio may be a surrogate of spongiform change in human prion diseases.. Brain, 133(10), 3058 - 3068. doi:10.1093/brain/awq243
    • Wadsworth JD, Asante EA, Collinge J (2010). Review: contribution of transgenic models to understanding human prion disease.. Neuropathol Appl Neurobiol, 36(7), 576 - 597. doi:10.1111/j.1365-2990.2010.01129.x
    • Grizenkova J, Akhtar S, Collinge J, Lloyd SE (2010). The Rarb Region of Mmu14 is Associated with Prion Disease Incubation Time. PRION, 4(3), 201 - 201.
    • Tattum MH, Jones S, Pal S, Khalili-Shirazi A, Collinge J, Jackson GS (2010). A highly sensitive immunoassay for the detection of prion-infected material in whole human blood without the use of proteinase K.. Transfusion, 50(12), 2619 - 2627. doi:10.1111/j.1537-2995.2010.02731.x
    • Collinge J (2010). Medicine. Prion strain mutation and selection.. Science, 328(5982), 1111 - 1112. doi:10.1126/science.1190815
    • Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, FReJA Consortium , Dickson DW, Rademakers R, Graff-Radford NR, Parisi JE, Petersen RC, Hatanpaa KJ, White CL, Weiner MF, Geser F, Van Deerlin VM, Trojanowski JQ, Miller BL, Seeley WW, van der Zee J, Kumar-Singh S, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bigio EH, Deng HX, Halliday GM, Kril JJ, Munoz DG, Mann DM, Pickering-Brown SM, Doodeman V, Adamson G, Ghazi-Noori S, Fisher EM, Holton JL, Revesz T, Rossor MN, Collinge J, Mead S, Isaacs AM (2010). FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.. Acta Neuropathol, 120(1), 33 - 41. doi:10.1007/s00401-010-0698-6
    • Urwin H, Authier A, Nielsen JE, Metcalf D, Powell C, Froud K, Malcolm DS, Holm I, Johannsen P, Brown J, Fisher EM, van der Zee J, Bruyland M, FReJA Consortium , Van Broeckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM (2010). Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations.. Hum Mol Genet, 19(11), 2228 - 2238. doi:10.1093/hmg/ddq100
    • Guerreiro RJ, Beck J, Gibbs JR, Santana I, Rossor MN, Schott JM, Nalls MA, Ribeiro H, Santiago B, Fox NC, Oliveira C, Collinge J, Mead S, Singleton A, Hardy J (2010). Genetic variability in CLU and its association with Alzheimer's disease.. PLoS One, 5(3), e9510 - . doi:10.1371/journal.pone.0009510
    • Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Peters O, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J (2010). Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.. PLoS One, 5(11), e13950 - . doi:10.1371/journal.pone.0013950
    • Hyare H, Thornton J, Stevens J, Mead S, Rudge P, Collinge J, Yousry TA, Jäger HR (2010). High-b-value diffusion MR imaging and basal nuclei apparent diffusion coefficient measurements in variant and sporadic Creutzfeldt-Jakob disease.. AJNR Am J Neuroradiol, 31(3), 521 - 526. doi:10.3174/ajnr.A1860
    • Lloyd SE, Maytham EG, Grizenkova J, Hummerich H, Collinge J (2010). A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse.. Neurogenetics, 11(2), 185 - 191. doi:10.1007/s10048-009-0219-8
    • D'Castro L, Wenborn A, Gros N, Joiner S, Cronier S, Collinge J, Wadsworth JD (2010). Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid.. PLoS One, 5(12), e15679 - . doi:10.1371/journal.pone.0015679
    • Nicoll AJ, Trevitt CR, Tattum MH, Risse E, Quaterman E, Ibarra AA, Jackson GS, Sessions RB, Farrow M, Waltho JP, Clarke AR, Collinge J (2010). A pharmacological chaperone for the structured domain of human prion protein. PRION, 4(3), 130 - 130.
    • Hosszu LL, Tattum MH, Jones S, Trevitt CR, Wells MA, Waltho JP, Collinge J, Jackson GS, Clarke AR (2010). The H187R mutation of the human prion protein induces conversion of recombinant prion protein to the PrP(Sc)-like form.. Biochemistry, 49(40), 8729 - 8738. doi:10.1021/bi100572j
    • Lukic A, Beck J, Joiner S, Fearnley J, Sturman S, Brandner S, Wadsworth JD, Collinge J, Mead S (2010). Heterozygosity at polymorphic codon 219 in variant creutzfeldt-jakob disease.. Arch Neurol, 67(8), 1021 - 1023. doi:10.1001/archneurol.2010.184
    • Wadsworth JD, Dalmau-Mena I, Joiner S, Linehan JM, O'Malley C, Powell C, Brandner S, Asante EA, Ironside JW, Hilton DA, Collinge J (2010). Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study.. J Pathol, , - . doi:10.1002/path.2821
    • Hyare H, Scahill R, Thornton JS, Collinge J, Siddique D, Carswell C, De Vita E, Yousry T, Rudge P, Mead S (2010). PAW23 Voxel-based analysis of magnetisation transfer ratio as a potential biomarker in prion diseases.. doi:10.1136/jnnp.2010.226340.52
    • Rudge P, Fox NC, Cipolotti L, Mead S, Hyare H, Rohrer J, Collinge J (2010). POD03 Distinct neuropsychological profiles correspond to distribution of cortical thinning in inherited prion disease caused by insertional mutation.. J Neurol Neurosurg Psychiatry, 81(11), e42 - e43. doi:10.1136/jnnp.2010.226340.103
    • Lukic A, Wadsworth J, Brandner S, Rudge P, Hyare H, Collinge J, Reiniger L, Mead S, Gilmore C, Humberstone M (2010). POD01 Misleading MRI in two recent patients with variant Creutzfeldt-Jakob disease emphasises the importance of tissue diagnosis.. J Neurol Neurosurg Psychiatry, 81(11), e42 - . doi:10.1136/jnnp.2010.226340.101
    • Thompson A, Rudge P, Wroe S, Mead S, Darbyshire J, Mackay A, Ranopa M, Collinge J, Gopalakrishnan G, Walker S (2010). POD04 Analysis of eight rating scales supports the use of functional outcome measures in prion disease clinical trials: experience from the PRION-1 trial and the National Prion Monitoring cohort.. doi:10.1136/jnnp.2010.226340.104
    • O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM (2010). Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.. J Neurosci, 30(43), 14411 - 14419. doi:10.1523/JNEUROSCI.3537-10.2010
    • Nicoll AJ, Trevitt CR, Tattum MH, Risse E, Quarterman E, Ibarra AA, Wright C, Jackson GS, Sessions RB, Farrow M, Waltho JP, Clarke AR, Collinge J (2010). Pharmacological chaperone for the structured domain of human prion protein.. Proc Natl Acad Sci U S A, 107(41), 17610 - 17615. doi:10.1073/pnas.1009062107
    • Edgeworth JA, Gros N, Alden J, Joiner S, Wadsworth JD, Linehan J, Brandner S, Jackson GS, Weissmann C, Collinge J (2010). Spontaneous generation of mammalian prions.. Proc Natl Acad Sci U S A, 107(32), 14402 - 14406. doi:10.1073/pnas.1004036107
    • Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J (2010). Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein.. J Gen Virol, 91(Pt 10), 2651 - 2657. doi:10.1099/vir.0.024380-0
    • Beck JA, Poulter M, Campbell TA, Adamson G, Uphill JB, Guerreiro R, Jackson GS, Stevens JC, Manji H, Collinge J, Mead S (2010). PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit.. Hum Mutat, 31(7), E1551 - E1563. doi:10.1002/humu.21281
    • Asante EA, Linehan JM, Smidak M, Brandner S, Collinge J (2010). Inherited prion disease A117V is transmissible to transgenic mice expressing PRNP 117-valine. PRION, 4(3), 156 - 156.
    • Mead S, Gandhi S, Carswell C, Ayling H, Beck J, Caine D, Gallujipali D, Hyare H, Joiner S, Lees AJ, Linehan J, Revesz T, Sandberg M, Wadsworth JDF, Warren JD, Wood NW, Holton JL, Collinge J (2010). Novel truncation mutation of PRNP causes chronic diarrhoea, sensory neuropathy and autonomic failure associated with prion protein deposition in the cerebral blood vessels and small bowel. PRION, 4(3), 201 - 202.
    • Edgeworth JA, Gros N, Alden J, Joiner S, Wadsworth J, Linehan J, Brandner S, Jackson G, Weissmann C, Collinge J (2010). Spontaneous formation of prions in brain tissue. PRION, 4(3), 140 - 140.
    • Castro-Seoane R, Hummerich H, Sweeting T, Sandberg M, Collinge J, Klohn PC (2010). Quantification of Infectious Titres Using a Generalized Linear Model. PRION, 4(3), 219 - 219.
    • Mead S, Thompson A, Gopalakrishnan G, Ranopa M, Rudge P, Wroe S, Hudson F, MacKay A, Darbyshire J, Collinge J, Walker S (2010). Analysis of Eight Rating Scales Supports the use of Functional Outcome Measures in Prion Disease Clinical Trials: Experience from the PRION-1 trial and the National Prion Monitoring Cohort.
    • Mead S, Hyare H, Collinge J, Rudge P (2010). Variant or sporadic Creutzfeldt-Jakob disease? reply. LANCET, 375(9718), 889 - 890.
    • Hyare H, Wroe S, Siddique D, Webb T, Fox NC, Stevens J, Collinge J, Yousry T, Thornton JS (2010). Brain-water diffusion coefficients reflect the severity of inherited prion disease. NEUROLOGY, 74(8), 658 - 665.
    • Tattum MH, Jones S, Pal S, Collinge J, Jackson GS (2010). Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification.. Transfusion, 50(5), 996 - 1002. doi:10.1111/j.1537-2995.2010.02595.x
    • Chia R, Tattum MH, Jones S, Collinge J, Fisher EM, Jackson GS (2010). Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis.. PLoS One, 5(5), e10627 - . doi:10.1371/journal.pone.0010627
    • Carswell C, Khalili-Shirazi A, Brandner S, Martins S, Drynda R, Collinge J, Mead S, Clarke A (2010). PAW35 Anti-prion protein monoclonal antibodies at low doses effectively treat prion disease in mice without side-effects.. J Neurol Neurosurg Psychiatry, 81(11), e33 - . doi:10.1136/jnnp.2010.226340.63

    2009

    • Urwin H, Ghazi-Noori S, Collinge J, Isaacs A (2009). The role of CHMP2B in frontotemporal dementia. Biochemical Society Transactions, 37(1), 208 - 212. doi:10.1042/BST0370208
    • Webb TEF, Whittaker J, Collinge J, Mead S (2009). Age of onset and death in inherited prion disease are heritable. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B(4), 496 - 501. doi:10.1002/ajmg.b.30844
    • Lloyd SE, Maytham EG, Pota H, Grizenkova J, Molou E, Uphill J, Hummerich H, Whitfield J, Alpers MP, Mead S, Collinge J (2009). HECTD2 is associated with susceptibility to mouse and human prion disease.. PLoS Genet, 5(2), e1000383 - . doi:10.1371/journal.pgen.1000383
    • Rossor M, Collinge J, Fox N, Howard R, Mallucci G, Mummery C, Warren J (2009). Cognitive impairment and dementia. In Clarke C, Howard R, Rossor M, Shorvon S (Ed.), Neurology: a Queen Square textbook (pp. 245 - 288). : Wiley-Blackwell.
    • Lloyd SE, Rossor M, Fox N, Mead S, Collinge J (2009). HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.. BMC Med Genet, 10, 90 - . doi:10.1186/1471-2350-10-90
    • Rohrer JD, Beck J, Warren JD, King A, Al Sarraj S, Holton J, Revesz T, Collinge J, Mead S (2009). Corticobasal syndrome associated with a novel 1048_1049insG progranulin mutation.. J Neurol Neurosurg Psychiatry, 80(11), 1297 - 1298. doi:10.1136/jnnp.2008.169383
    • Kaski D, Pennington C, Beck J, Poulter M, Uphill J, Bishop M, Lineham J, Powell C, Brandner S, Knight R, Collinge J, Mead S (2009). INHERITED PRION DISEASE WITH 4-OCTAPEPTIDE REPEAT INSERTION - A DISEASE THAT REQUIRES THE INTERACTION OF MULTIPLE GENETIC RISK FACTORS. doi:10.1136/jnnp.2009.191759p
    • Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2009). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.. Nat Genet, 41(10), 1088 - 1093. doi:10.1038/ng.440
    • Webb T, Mead S, Beck J, Uphill J, Pal S, Hampson S, Wadsworth JD, Dalmau Mena I, O'Malley C, Wroe S, Schapira A, Brandner S, Collinge J (2009). Seven year discordance in age at onset in monozygotic twins with inherited prion disease (P102L). Neuropathology and Applied Neurobiology, 35(4), 427 - 432. doi:10.1111/j.1365-2990.2009.01012.x
    • Hosszu LLP, Trevitt CR, Jones S, Batchelor M, Scott DJ, Jackson GS, Collinge J, Waltho JP, Clarke AR (2009). Conformational properties of beta-PrP. Journal of Biological Chemistry, 284(33), 21981 - 21990. doi:10.1074/jbc.M809173200
    • Lloyd SE, Grizenkova J, Pota H, Collinge J (2009). Shadoo (Sprn) and prion disease incubation time in mice. Mammalian Genome, 20(6), 367 - 374. doi:10.1007/s00335-009-9194-5
    • Hart T, Hosszu LLP, Trevitt CR, Jackson GS, Waltho JP, Collinge J, Clarke AR (2009). Folding kinetics of the human prion protein probed by temperature jump. Proceedings of the National Academy of Sciences of the United States of America, 106(14), 5651 - 5656. doi:10.1073/pnas.0811457106
    • Collinge J, Gorham M, Hudson F, Kennedy A, Keogh G, Pal S, Rossor M, Rudge P, Siddique D, Spyer M, Thomas D, Walker S, Webb T, Wroe S, Darbyshire J (2009). Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial. The Lancet Neurology, 8(4), 334 - 344. doi:10.1016/S1474-4422(09)70049-3
    • Rollinson S, Rizzu P, Sikkink S, Baker M, Halliwell N, Snowden J, Traynor BJ, Ruano D, Cairns N, Rohrer JD, Mead S, Collinge J, Rossor M, Akay E, Guerreiro R, Rademakers R, Morrison KE, Pastor P, Alonso E, Martinez-Lage P, Graff-Radford N, Neary D, Heutink P, Mann DMA, Van Swieten J, Pickering-Brown SM (2009). Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. Neurobiology of Aging, 30(4), 656 - 665. doi:10.1016/j.neurobiolaging.2009.01.009
    • Ingram RJ, Isaacs JD, Kaur G, Lowther DE, Reynolds CJ, Boyton RJ, Collinge J, Jackson GS, Altmann DM (2009). A role of cellular prion protein in programming T-cell cytokine responses in disease. The FASEB Journal, 23(6), 1672 - 1684. doi:10.1096/fj.08-116087
    • Asante EA, Gowland I, Grimshaw A, Linehan JM, Smidak M, Houghton R, Osiguwa O, Tomlinson A, Joiner S, Brandner S, Wadsworth JD, Collinge J (2009). Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins. Journal of General Virology, 90(3), 546 - 558. doi:10.1099/vir.0.007930-0
    • Lukic A, Beck JA, Wadsworth JDF, Brandner S, Collinge J, Mead S (2009). HETEROZYGOSITY AT POLYMORPHIC CODON 219 IN TWO VARIANT CREUTZFELDT-JAKOB DISEASE PATIENTS. doi:10.1136/jnnp.2009.191759o
    • Collinge J (2009). Prion disease. In Gelder MG, Lopez-Ibor Jnr JJ, Andreasen NC (Ed.), Oxford textbook of psychiatry (pp. 404 - 415). : Oxford University Press.
    • Mead S, Rudge P, Hudson F, Walker S, Darbyshire J, Collinge J, PRION-1 Investigators (2009). Clinical trials and methodological problems in prion diseases Reply. LANCET NEUROL, 8(9), 782 - 783.
    • Mead S, Gajulapalli D, Walker S, Wroe S, Rudge P, Collinge J (2009). THE NATIONAL PRION MONITORING COHORT: A LONGITUDINAL OBSERVATIONAL STUDY OF UK HUMAN PRION INFECTION.
    • Siddique D, Wroe S, Hyare H, Webb T, Macfarlane R, Collinge J, Walker S, Yousry T, Thornton JS (2009). A CORRELATION OF GLOBAL AND TISSUE-SPECIFIC CEREBRAL MAGNETISATION TRANSFER RATIOS WITH DISEASE SEVERITY IN INHERITED PRION DISEASE.
    • Siddique D, Wroe S, Hyare H, Webb T, Macfarlane R, Collinge J, Walker S, Yousry T, Thornton J (2009). Whole Brain MTR25% a Valuable Outcome Measure in Prion Disease Therapeutic Trials.
    • Edgeworth JA, Jackson GS, Clarke AR, Weissmann C, Collinge J (2009). Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces. Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3479 - 3483. doi:10.1073/pnas.0813342106
    • Tayebi M, Collinge J, Hawke S (2009). Unswitched immunoglobulin M response prolongs mouse survival in prion disease. Journal of General Virology, 90(3), 777 - 782. doi:10.1099/vir.0.005041-0
    • Nicoll A, Collinge J (2009). Preventing prion pathogenicity by targeting the cellular prion protein. Infectious Disorders - Drug Targets, 9(1), 48 - 57.
    • Mead S, Poulter M, Uphill J, Beck J, Whitfield J, Webb TEF, Campbell T, Adamson G, Deriziotis P, Tabrizi SJ, Hummerich H, Verzilli C, Alpers MP, Whittaker JC, Collinge J (2009). Genetic risk factors for variant Creutzfeldt–Jakob disease: a genome-wide association study. The Lancet Neurology, 8(1), 57 - 66. doi:10.1016/S1474-4422(08)70265-5
    • Collinge J (2009). Prion disease. In Gelder MG, Andreasen NC, Lopez-Ibor JJ, Geddes JR (Ed.), New Oxford Textbook of Psychiatry (pp. 351 - 361). : Oxford University Press.
    • Collinge J (2009). Human prion diseases. In Zuckerman A (Ed.), Principles & practice of clinical virology (pp. 939 - 968). : John Wiley & Sons.
    • Kaski D, Mead S, Hyare H, Cooper S, Jampana R, Overell J, Knight R, Collinge J, Rudge P (2009). Variant CJD in an individual heterozygous for PRNP codon 129. LANCET, 374(9707), 2128 - 2128.
    • Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, Al-Dujaily H, Hummerich H, Beck J, Mein CA, Verzilli C, Whittaker J, Alpers MP, Collinge J (2009). A novel protective prion protein variant that colocalizes with kuru exposure.. N Engl J Med, 361(21), 2056 - 2065. doi:10.1056/NEJMoa0809716
    • Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schurmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frolich L, Hampel H, Hull M, Rujescu D, Goate AM, Kauwe JSK, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Muhleisen TW, Nothen MM, Moebus S, Jockel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2009). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (vol 41, pg 1088, 2009). NAT GENET, 41(10), 1156 - 1156. doi:10.1038/ng1009-1156d
    • Antonyuk SV, Trevitt CR, Strange RW, Jackson GS, Sangar D, Batchelor M, Cooper S, Fraser C, Jones S, Georgiou T, Khalili-Shirazi A, Clarke AR, Hasnain SS, Collinge J (2009). Crystal structure of human prion protein bound to a therapeutic antibody. Proceedings of the National Academy of Sciences of the United States of America, 106(8), 2554 - 2558. doi:10.1073/pnas.0809170106

    2008

    • Collinge J, Alpers MP (2008). Introduction.. Philos Trans R Soc Lond B Biol Sci, 363(1510), 3607 - 3612. doi:10.1098/rstb.2008.0103
    • O'Shea M, Maytham EG, Linehan JM, Brandner S, Collinge J, Lloyd SE (2008). Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse.. Genetics, 180(1), 559 - 566. doi:10.1534/genetics.108.090894
    • Whitfield JT, Pako WH, Collinge J, Alpers MP (2008). Mortuary rites of the South Fore and kuru. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3721 - 3724. doi:10.1098/rstb.2008.0074
    • Webb TEF, Poulter M, Beck J, Uphill J, Adamson G, Campbell T, Linehan J, Powell C, Brandner S, Pal S, Siddique D, Wadsworth JD, Joiner S, Alner K, Petersen C, Hampson S, Rhymes C, Treacy C, Storey E, Geschwind MD, Nemeth AH, Wroe S, Collinge J, Mead S (2008). Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series. Brain, 131(10), 2632 - 2646. doi:10.1093/brain/awn202
    • Webb TEF, Pal S, Siddique D, Heaney DC, Linehan JM, Wadsworth JDF, Joiner S, Beck J, Wroe SJ, Stevenson V, Brandner S, Mead S, Collinge J (2008). First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation. Journal of Neuropathology and Experimental Neurology, 67(9), 838 - 841. doi:10.1097/NEN.0b013e318182f36e
    • O'Shea M, Maytham EG, Linehan JM, Brandner S, Collinge J, Lloyd SE (2008). Investigation of Mcp1 as a quantitative trait gene for prion disease incubation time in mouse. Genetics, 180(1), 559 - 566. doi:10.1534/genetics.108.090984
    • Rohrer JD, Warren JD, Barnes J, Mead S, Beck J, Pepple T, Boyes R, Omar R, Collinge J, Stevens JM, Warrington EK, Rossor MN, Fox NC (2008). Mapping the progression of progranulin-associated frontotemporal lobar degeneration. Nature Clinical Practice Neurology, 4(8), 455 - 460. doi:10.1038/ncpneuro0869
    • Isaacs AM, Powell C, Webb TE, Linehan JM, Collinge J, Brandner S (2008). Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases. Neuropathology and Applied Neurobiology, 34(4), 446 - 456. doi:10.1111/j.1365-2990.2008.00963.x
    • White MD, Farmer M, Mirabile I, Brandner S, Collinge J, Mallucci GR (2008). Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease. Proceedings of the National Academy of Sciences of the United States of America, 105(29), 10238 - 10243. doi:10.1073/pnas.0802759105
    • Powell AD, Toescu EC, Collinge J, Jefferys JGR (2008). Alterations in Ca2+-buffering in prion-null mice: Association with reduced afterhyperpolarizations in CA1 hippocampal neurons. Journal of Neuroscience, 28(15), 3877 - 3886. doi:10.1523/JNEUROSCI.0675-08.2008
    • Rohrer JD, Warren JD, Omar R, Mead S, Beck J, Revesz T, Holton J, Stevens JM, Al-Sarraj S, Pickering-Brown SM, Hardy J, Fox NC, Collinge J, Warrington EK, Rossor MN (2008). Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene. Archives of Neurology, 65(4), 506 - 513. doi:10.1001/archneur.65.4.506
    • Beck J, Rohrer JD, Campbell T, Isaacs A, Morrison KE, Goodall EF, Warrington EK, Stevens J, Revesz T, Holton J, Al-Sarraj S, King A, Scahill R, Warren JD, Fox NC, Rossor MN, Collinge J, Mead S (2008). A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain, 131(3), 706 - 720. doi:10.1093/brain/awm320
    • Wadsworth JDF, Powell C, Beck JA, Joiner S, Linehan JM, Brandner S, Mead S, Collinge J (2008). Molecular diagnosis of human prion disease. Methods in Molecular Biology, 459, 197 - 227. doi:10.1007/978-1-59745-234-2_14
    • van der Zee J, Urwin H, Engelborghs S, Bruyland M, Vandenberghe R, Dermaut B, De Pooter T, Peeters K, Santens P, De Deyn PP, Fisher EM, Collinge J, Isaacs AM, Van Broeckhoven C (2008). CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro.. Hum Mol Genet, 17(2), 313 - 322. doi:10.1093/hmg/ddm309
    • Wadsworth JD, Collinge J (2008). Prions of vertebrates. In Mahy BWJ, Van Regenmoretl MHV (Ed.), Encyclopedia of virology (pp. 330 - 336). : Elsevier Academic Press.
    • Wadsworth JDF, Joiner S, Linehan JM, Asante EA, Brandner S, Collinge J (2008). Review: The origin of the prion agent of kuru: molecular and biological strain typing. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3747 - 3753. doi:10.1098/rstb.2008.0069
    • Collinge J, Alpers MP (2008). Reminiscences and reflections on kuru, personal and scientific. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3613 - . doi:10.1098/rstb.2008.0098
    • Wadsworth JD, Powell C, Beck JA, Joiner S, Linehan J, Brandner S, Mead S, Collinge J (2008). Molecular diagnosis of human prion disease. In Hill AF (Ed.), Methods in molecular biology: prion protein protocols (pp. 197 - 228). : Humana Press.
    • Brandner S, Whitfield J, Boone K, Puwa A, O'Malley C, Linehan JM, Joiner S, Scaravilli F, Calder I, Alpers MP, Wadsworth JD, Collinge J (2008). Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3755 - 3763. doi:10.1098/rstb.2008.0091
    • Wadsworth JDF, Joiner S, Linehan JM, Desbruslais M, Fox K, Cooper S, Cronier S, Asante EA, Mead S, Brandner S, Hill AF, Collinge J (2008). Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice.. Proceedings of the National Academy of Sciences of the United States of America, 105(10), 3885 - 3890. doi:10.1073/pnas.0800190105
    • Beck JA, Campbell TA, Adamson G, Poulter M, Uphill JB, Molou E, Collinge J, Mead S (2008). Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. Journal of Medical Genetics, 45(12), 813 - 817. doi:10.1136/jmg.2008.061804
    • Mead S, Poulter M, Beck J, Uphill J, Jones C, Ang CE, Mein CA, Collinge J (2008). Successful amplification of degraded DNA for use with high-throughput SNP genotyping platforms. Human Mutation, 29(12), 1452 - 1458. doi:10.1002/humu.20782
    • Cronier S, Gros N, Tattum MH, Jackson GS, Clarke AR, Collinge J, Wadsworth JD (2008). Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin. Biochemical Journal, 416(2), 297 - 305. doi:10.1042/BJ20081235
    • Collinge J (2008). Review. Lessons of kuru research: background to recent studies with some personal reflections. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3689 - 3696. doi:10.1098/rstb.2008.0121
    • Collinge J, Whitfield J, McKintosh E, Frosh A, Mead S, Hill AF, Brandner S, Thomas D, Alpers MP (2008). A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3725 - 3739. doi:10.1098/rstb.2008.0068
    • Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Beck J, Campbell T, Al-Dujaily H, Hummerich H, Alpers MP, Collinge J (2008). Genetic susceptibility, evolution and the kuru epidemic. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3741 - 3746. doi:10.1098/rstb.2008.0087
    • Isaacs JD, Garden OA, Kaur G, Collinge J, Jackson GS, Altmann DM (2008). The cellular prion protein is preferentially expressed by CD4+ CD25+ Foxp3+ regulatory T cells.. Immunology, 125(3), 313 - 319. doi:10.1111/j.1365-2567.2008.02853.x
    • Ratte S, Prescott SA, Collinge J, Jefferys JGR (2008). Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD. Neurobiology of Disease, 32(1), 96 - 104. doi:10.1016/j.nbd.2008.06.007
    • Collinge J, Alpers MP (2008). Introduction: It was an extraordinary meeting that is reflected in the proceedings published in this issue of the Philosophical Transactions of the Royal Society. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1510), 3607 - 3612.

    2007

    • Khalili-Shirazi A, Kaisar M, Mallinson G, Jones S, Bhelt D, Fraser C, Clarke AR, Hawke SH, Jackson GS, Collinge J (2007). beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrP(Sc). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1774(11), 1438 - 1450. doi:10.1016/j.bbapap.2007.08.028
    • Pal S, Siddique D, Hyare H, Hewitt P, Collinge J, Wroe SJ (2007). Ante-mortem presentation of blood transfusion association vCJD.
    • Pal S, Webb T, Alner K, Hewitt P, Brander S, Wadsworth JD, Collinge J, Wroe SJ (2007). Atypical presentation of variant Creutzfeldt-Jakob disease in a 73-year-old transfusion recipient.
    • Rohrer JD, Warren JD, Omar R, Mead S, Beck J, Stevens JM, Revesz T, Holton J, Collinge J, Hardy J, Warrington EK, Fox NC, Rossor MN (2007). Parietal lobe deficits are a feature of frontotemporal lobar degeneration caused by a mutation in the progranulin gene.
    • Mead S, Webb TE, Campbell TA, Beck J, Linehan JM, Rutherfoord S, Joiner S, Wadsworth JD, Heckmann J, Wroe S, Doey L, King A, Collinge J (2007). Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129. Neurology, 69(8), 730 - 738. doi:10.1212/01.wnl.0000267642.41594.9d
    • Rohrer JD, Warren JD, Omar R, Barnes J, Mead S, Beck J, Collinge J, Stevens JM, Warrington EK, Rossor MN, Fox NC (2007). Longitudinal clinical, radiological and neuropsychological profile of an at-risk family member from a kindred with progranulin-associated frontotemporal lobar degeneration.
    • Knight WD, Kennedy J, Mead S, Rossor MN, Beck J, Collinge J, Mummery C (2007). A novel presenilin 1 deletion (p.L166del) associated with early onset familial Alzheimer's disease. European Journal of Neurology, 14(7), 829 - 831. doi:10.1111/j.1468-1331.2007.01857.x
    • Macfarlane RG, Wroe SJ, Collinge J, Yousry TA, Jager HR (2007). Neuroimaging findings in human prion disease. Journal of Neurology, Neurosurgery and Psychiatry, 78(7), 664 - 670.
    • Mallucci GR, White MD, Farmer M, Dickinson A, Khatun H, Powell AD, Brandner S, Jefferys JG, Collinge J (2007). Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice. Neuron, 53(3), 325 - 335. doi:10.1016/j.neuron.2007.01.005
    • Pal S, Jones S, Collinge J, Jackson GS (2007). A novel method for immunodiagnosis of variant Creutzfeldt- Jakob disease.
    • Webb T, Pal S, Siddique D, Heaney D, Brandner S, Wroe S, Stevenson V, Collinge J (2007). Sporadic Creutzfeldt-Jakob disease occurring in two siblings.
    • Wadsworth JDF, Joiner S, Fox K, Linehan JM, Desbruslais M, Brandner S, Asante EA, Collinge J (2007). Prion infectivity in variant Creutzfeldt-Jakob disease rectum. Gut, 56(1), 90 - 94. doi:10.1136/gut.2006.091637
    • Stone LA, Jackson GS, Collinge J, Wadsworth JD, Clarke AR (2007). Inhibition of proteinase K activity by copper(II) ions. Biochemistry, 46(1), 245 - 252.
    • Kovacs T, Beck JA, Papp MI, Lantos PL, Aranyi Z, Szirmai IG, Farsang M, Stuke A, Csillik A, Collinge J (2007). Familial prion disease in a Hungarian family with a novel 144-base pair insertion in the prion protein gene. Journal of Neurology, Neurosurgery and Psychiatry, 78(3), 321 - 323. doi:10.1136/jnnp.2006.104372
    • Wadsworth JD, Collinge J (2007). Update on human prion disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1772(6), 598 - 609. doi:10.1016/j.bbadis.2007.02.010
    • Mead S, Joiner S, Desbruslais M, Beck JA, O'Donoghue M, Lantos P, Wadsworth JD, Collinge J (2007). Creutzfeldt-Jakob disease, prion protein gene codon 129VV, and a novel PrPSc type in a young British woman. Archives of Neurology, 64(12), 1780 - 1784.
    • Siddique D, Wroe SJ, Hyare H, Webb TEF, Pal S, Collinge J, Walker S, Yousry T, Thornton J (2007). Correlation of magnetisation transfer ratio histogram measures with clinical disease severity in Inherited Prion Disease.
    • Siddique D, Wroe S, Hyare H, Webb T, Pal S, Collinge J, Walker S, Yousry T, Thornton JS (2007). A correlation of magnetisation transfer ratio histogram measures with clinical disease severity in inherited prion disease.
    • Webb T, Mead S, Poulter M, Beck J, Uphill J, Campbell T, Adamson G, Pal S, Siddique D, Treacy C, Brandner S, Wroe S, Collinge J (2007). Inherited prion disease with the P102L mutation: Update of a worldwide kindred originating in England and multiple unrelated European kindreds.
    • Smithson S, Leonard S, James MA, King C, Newbury-Ecob RA, Wroe SJ, Collinge J, Mead S (2007). Inherited Creutzfeldt-Jakob disease: phenotypes, genotypes and public health implications.
    • Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FWB, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ (2007). Disease-associated prion protein oligomers inhibit the 26S proteasome.. Molecular Cell, 26(2), 175 - 188. doi:10.1016/j.molcel.2007.04.001
    • Collinge J, Clarke AR (2007). A general model of prion strains and their pathogenicity. Science, 318(5852), 930 - 936. doi:10.1126/science.1138718

    2006

    • Wroe SJ, Pal S, Siddique D, Hyare H, MacFarlane R, Joiner S, Linehan JM, Brandner S, Wadsworth JDF, Hewitt P, Collinge J (2006). Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report. The Lancet, 368(9552), 2061 - 2067.
    • Wells MA, Jelinska C, Hosszu LLP, Craven CJ, Clarke AR, Collinge J, Waltho JP, Jackson GS (2006). Multiple forms of copper (II) co-ordination occur throughout the disordered N-terminal region of the prion protein at pH 7.4. Biochemical Journal, 400(3), 501 - 510.
    • Rohrer JD, Mead S, Omar R, Poulter M, Warren JD, Collinge J, Rossor MN (2006). Prion protein (PRNP) genotypes in frontotemporal lobar degeneration syndromes. Annals of Neurology, 60(5), 616 - 616.
    • Wells MA, Jackson GS, Jones S, Hosszu LLP, Craven CJ, Clarke AR, Collinge J, Waltho JP (2006). A reassessment of copper(II) binding in the full-length prion protein. Biochemical Journal, 399(3), 435 - 444.
    • Kotta K, Paspaltsis I, Bostantjopoulou S, Latsoudis H, Plaitakis A, Kazis D, Collinge J, Sklaviadis T (2006). Novel mutation of the PRNP gene of a clinical CJD case. BMC Infectious Diseases, 6, 169 - . doi:10.1186/1471-2334-6-169
    • Isaacs JD, Ingram RJ, Collinge J, Altmann DM, Jackson GS (2006). The human prion protein residue 129 polymorphism lies within a cluster of epitopes for T cell recognition.. J Neuropathol Exp Neurol, 65(11), 1059 - 1068. doi:10.1097/01.jnen.0000240467.18381.49
    • Collinge J, Alpers MP (2006). Incubation period of human prion disease - Reply. LANCET, 368(9539), 914 - 915.
    • Mead S, Poulter M, Beck J, Webb TEF, Campbell TA, Linehan JM, Desbruslais M, Joiner S, Wadsworth JDF, King A, Lantos P, Collinge J (2006). Inherited prion disease with six octapeptide repeat insertional mutation - molecular analysis of phenotypic heterogeneity. Brain, 129(9), 2297 - 2317.
    • Tattum MH, Cohen-Krausz S, Thumanu K, Wharton CW, Khalili-Shirazi A, Jackson GS, Orlova EV, Collinge J, Clarke AR, Saibil HR (2006). Elongated oligomers assemble into mammalian PrP amyloid fibrils (vol 357, pg 975, 2006). J MOL BIOL, 361(4), 811 - 811. doi:10.1016/j.jmb.2006.06.001
    • Waldman AD, Cordery RJ, MacManus DG, Godbolt A, Collinge J, Rossor MN (2006). Regional brain metabolite abnormalities in inherited prion disease and asymptomatic gene carriers demonstrated in vivo by quantitative proton magnetic resonance spectroscopy. Neuroradiology, 48(6), 428 - 433. doi:10.1007/s00234-006-0068-1
    • Collinge J, Whitfield J, McKintosh E, Beck J, Mead S, Thomas DJ, Alpers MP (2006). Kuru in the 21st century - an acquired human prion disease with very long incubation periods. The Lancet, 367(9528), 2068 - 2074.
    • Lewis PA, Properzi F, Prodromidou K, Clarke AR, Collinge J, Jackson GS (2006). Removal of the glycosylphosphatidylinositol anchor from PrPSc by cathepsin D does not reduce prion infectivity. Biochemical Journal, 395(2), 443 - 448.
    • Tattum MH, Cohen-Krausz S, Khalili-Shirazi A, Jackson GS, Orlova EV, Collinge J, Clarke AR, Saibil HR (2006). Elongated oligomers assemble into mammalian PrP amyloid fibrils. Journal of Molecular Biology, 357(3), 975 - 985.
    • Godbolt AK, Beck JA, Collinge JC, Cipolotti L, Fox NC, Rossor MN (2006). A second family with familial AD and the V717L APP mutation has a later age at onset. Neurology, 66(4), 611 - 612.
    • Trevitt CR, Collinge J (2006). A systematic review of prion therapeutics in experimental models. Brain, 129(9), 2241 - 2265.
    • Trevitt CR, Collinge J (2006). A systematic review of prion therapeutics in experimental models. BRAIN, 129, 2241 - 2265. doi:10.1093/brain/aw1150
    • Mead S, Poulter M, Beck J, Webb TEF, Campbell TA, Linehan JM, Desbruslais M, Joiner S, Wadsworth JDF, King A, Lantos P, Collinge J (2006). Inherited prion disease with six octapeptide repeat insertional mutation - molecular analysis of phenotypic heterogeneity. BRAIN, 129, 2297 - 2317. doi:10.1093/brain/aw1226
    • Lewis PA, Tattum MH, Jones S, Bhelt D, Batchelor M, Clarke AR, Collinge J, Jackson GS (2006). Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation. Journal of General Virology, 87(8), 2443 - 2449.
    • Skibinski G, Parkinson N, Fisher E, Collinge J, Freja Consortium (2006). Mutations in the endosomal ESCRTIII complex subunit CHMP2B in frontotemporal dementia.
    • Asante EA, Linehan JM, Gowland I, Joiner S, Fox K, Cooper S, Osiguwa O, Gorry M, Welch J, Houghton R, Desbruslais M, Brandner S, Wadsworth JD, Collinge J (2006). Dissociation of pathological and molecular phenotype of variant Creutzfeldt-Jakob disease in transgenic human prion protein 129 heterozygous mice. Proceedings of the National Academy of Sciences of the United States of America, 103(28), 10759 - 10764. doi:10.1073/pnas.0604292103
    • Wadsworth JDF, Joiner S, Linehan JM, Cooper S, Powell C, Mallinson G, Buckell J, Gowland I, Asante EA, Budka H, Brandner S, Collinge J (2006). Phenotypic heterogeneity in inherited prion disease (P102L) is associated with differential propagation of protease-resistant wild-type and mutant prion protein. Brain, 129(6), 1557 - 1569.
    • Hill AF, Joiner S, Beck JA, Campbell TA, Dickinson A, Poulter M, Wadsworth JDF, Collinge J (2006). Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations. Brain, 129(3), 676 - 685.
    • Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE, Pall HS, Hardiman O, Collinge J, Shaw PJ, EMC F, Study MRCPIALS, Consortium F (2006). ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B).. Neurology, 67(6), 1074 - 1077. doi:10.1212/01.wnl.0000231510.89311.8b
    • Collinge J, Wadsworth JDF (2006). Molecular basis of prion diseases. In Siegel GJ, Albers RW, Brady ST, Price DL (Ed.), Basic neurochemistry: molecular, cellular, and medical aspects (pp. 791 - 803). : Elsevier Academic Press.
    • Webb T, Pal S, Siddique D, Brandner S, Wroe S, Collinge J (2006). Bilateral sequential alien limb in a pathologically confirmed case of Creutzfeldt-Jakob disease (SCJD).
    • Wadsworth JDF, Collinge J (2006). Molecular pathology of prion diseases. In Turner M (Ed.), Creutzfeldt-Jakob disease: managing the risk of transfusion transmission (pp. 1 - 36). : American Association of Blood Banks Press.
    • Jackson GS, ELECTROPHORETICS LTD, MEDICAL RESEARCH COUNCIL, UNIVERSITY COLLEGE LONDON, Ward MA, Collinge J, McGregor E, Leeds NL, Campbell J, Westbrook JA, Byers HL (2006). Diagnosis of neurodegenerative diseases.

    2005

    • Siddique D, Kennedy A, Thomas D, Wroe S, Stevens J, Wadsworth J, Brandner S, Linehan J, Joiner S, Jones J, Frosh A, Hill D, Tolley N, Rossor M, Collinge J (2005). Tonsil biopsy in the investigation of suspected variant Creutzfeldt-.Jakob disease - A cohort study of 50 patients.
    • Wroe S, Thomas D, Rossor M, Walker A, Keogh G, Siddique D, Webb T, Pal S, Darbyshire J, Collinge J (2005). PRION-1 TRIAL: Therapies for human prion disease (ISRCTN06722585).
    • McKintosh E, Jackson G, Flechsig E, Prodromidou K, Hirsch P, Linehan J, Brandner S, Clarke A, Weissmann C, Collinge J (2005). A detergent-enzyme method for effective prion decontamination of surgical steel.
    • Mallucci G, Collinge J (2005). Rational targeting for prion therapeutics. Nature Reviews Neuroscience, 6(1), 23 - 34.
    • Lloyd SE, Collinge J (2005). Genetic susceptibility to Prion diseases in humans and mice. Current Genomics, 6(1), 1 - 11.
    • Jackson GS, McKintosh E, Flechsig E, Prodromidou K, Hirsch P, Linehan J, Brandner S, Clarke AR, Weissmann C, Collinge J (2005). An enzyme-detergent method for effective prion decontamination of surgical steel. Journal of General Virology, 86(3), 869 - 878.
    • Mead S, Prout K, Collinge J (2005). Questionnaire to reduce the risk of iatrogenic prion disease transmission. Journal of Hospital Infection, 60(4), 378 - 379.
    • Kennedy A, Siddique D, Thomas DJ, Hill D, Tolley N, Collinge J (2005). Tonsil biopsy in the investigation of suspected variant Creutzfeldt-Jakob disease - A cohort study of 50 patients.
    • Kristiansen M, Messenger MJ, Klohn PC, Brandner S, Wadsworth JD, Collinge J, Tabrizi SJ (2005). Disease-related prion protein forms aggresomes in neuronal cells leading to caspase-activation and apoptosis. Journal of Biological Chemistry, 280(46), 38851 - 38861. doi:10.1074/jbc.M506600200
    • Hosszu LL, Wells MA, Jackson GS, Jones S, Batchelor M, Clarke AR, Craven CJ, Waltho JP, Collinge J (2005). Definable equilibrium states in the folding of human prion protein. Biochemistry, 44(50), 16649 - 16657.
    • Jones S, Batchelor M, Bhelt D, Clarke AR, Collinge J, Jackson GS (2005). Recombinant prion protein does not possess SOD-1 activity. Biochemical Journal, 392(2), 309 - 312.
    • Collinge J (2005). Creutzfeldt-Jakob disease and other prion diseases. In O'Brien JT, Ames D, Burns A (Ed.), Dementia (pp. 763 - 776). : Oxford University Press.
    • Khalili-Shirazi A, Quaratino S, Londei M, Jackson G, Collinge J (2005). Protein conformation influences immune responses to prion protein..
    • Cordery RJ, Alner K, Cipolotti L, Ron M, Kennedy A, Collinge J, Rossor MN (2005). The neuropsychology of variant CJD: a comparative study with inherited and sporadic forms of prion disease. Journal of Neurology, Neurosurgery and Psychiatry, 76(3), 330 - 336.
    • Khalili-Shirazi A, Quaratino S, Londei M, Summers L, Tayebi M, Clarke AR, Hawke SH, Jackson GS, Collinge J (2005). Protein conformation significantly influences immune responses to prion protein. The Journal of Immunology, 174(6), 3256 - 3263.
    • Collinge J (2005). Molecular neurology of prion disease. Journal of Neurology, Neurosurgery and Psychiatry, 76(7), 906 - 919.
    • Hirsch N, Beckett A, Collinge J, Scaravilli F, Tabrizi S, Berry S (2005). Lymphocyte contamination of laryngoscope blades - a possible vector for transmission of variant Creutzfeldt-Jakob disease. Anaesthesia, 60(7), 664 - 667.
    • Skibinski G, Parkinson NJ, Brown JM, Chakrabarti L, Lloyd SL, Hummerich H, Nielsen JE, Hodges JR, Spillantini MG, Thusgaard T, Brandner S, Brun A, Rossor MN, Gade A, Johannsen P, Sorensen SA, Gydesen S, EMC F, Collinge J (2005). Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia. NAT GENET, 37(8), 806 - 808. doi:10.1038/ng1609
    • Khalili-Shirazi A, Summers L, Linehan J, Mallinson G, Anstee D, Hawke S, Jackson GS, Collinge J (2005). PrP glycoforms are associated in a strain-specific ratio in native PrPSc. Journal of General Virology, 86(9), 2635 - 2644.
    • Joiner S, Linehan JM, Brandner S, Wadsworth JDF, Collinge J (2005). High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease. Gut, 54(10), 1506 - 1508.

    2004

    • Beringue V, Vilette D, Mallinson G, Archer F, Kaisar M, Tayebi M, Jackson GS, Clarke AR, Laude H, Collinge J, Hawke S (2004). PrPSc binding antibodies are potent inhibitors of prion replication in cell lines. Journal of Biological Chemistry, 279(38), 39671 - 39676.
    • Hill AF, Collinge J (2004). Prion strains and species barriers.. Contrib Microbiol, 11, 33 - 49.
    • Medical Research COUNCIL, Jackson GS, Collinge J, Clarke AR (2004). Prion decontamination.
    • Asante EA, Li YG, Gowland I, Jefferys JG, Collinge J (2004). Pathogenic human prion protein rescues PrP null phenotype in transgenic mice. Neuroscience Letters, 360(1-2), 33 - 36.
    • Beck JA, Poulter M, Campbell TA, Uphill JB, Adamson G, Geddes JF, Revesz T, Davis MB, Wood NW, Collinge J, Tabrizi SJ (2004). Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease. Human Molecular Genetics, 13(12), 1219 - 1224. doi:10.1093/hmg/ddh134
    • Beck JA, Poulter M, Campbell T, Uphill JB, Adamson G, Geddes JF, Revesz T, Davis M, Wood NW, Collinge J, Tabrizi SJ (2004). Nuclear somatic mosaicism in sporadic early-onset Alzheimer's disease.
    • Hosszu LLP, Jackson GS, Trevitt CR, Jones S, Batchelor M, Bhelt D, Prodromidou K, Clarke AR, Waltho JP, Collinge J (2004). The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC. Journal of Biological Chemistry, 279(27), 28515 - 28521.
    • Frosh A, Smith LC, Jackson CJ, Linehan JM, Brandner S, Wadsworth JDF, Collinge J (2004). Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein. The Lancet, 364(9441), 1260 - 1262.
    • Godbolt A, Beck J, Collinge J, Garrard P, Warren JD, Fox NC, Rossor MN (2004). A presenilin 1 R2781 mutation presenting with language impairment. Neurology, 63(9), 1702 - 1704.
    • Mallucci G, Collinge J (2004). Update on Creutzfeldt-Jakob disease. Current Opinion in Neurology, 17(6), 641 - 647.
    • Wadsworth JD, Asante EA, Desbruslais M, Linehan JM, Joiner S, Gowland I, Welch J, Stone L, Lloyd SE, Hill AF, Brandner S, Collinge J (2004). Human prion protein with valine 129 prevents expression of variant CJD phenotype. Science, 306(5702), 1793 - 1796. doi:10.1126/science.1103932
    • Tayebi M, Enever P, Sattar Z, Collinge J, Hawke S (2004). Disease-associated prion protein elicits immunoglobulin M responses in vivo. Molecular Medicine, 10(7-12), 104 - 111.
    • Collinge J (2004). Human prion diseases. In Zuckerman AJ, Banatvala JE, Pattison JR, Griffiths PD, Schoub BD (Ed.), Principles and practice of clinical virology (pp. 779 - 811). : John Wiley.
    • Hill AF, Asante EA, Collinge J (2004). Bioassays for prions. In Nunnally BK, Krull IS (Ed.), Prions and mad cow disease (pp. 151 - 179). : Marcel Dekker.
    • Brown J, Gydesen S, Johannsen P, Gade A, Skibinski G, Chakrabarti L, Brun A, Spillantini M, Yancopoulou D, Thusgaard T, Sorensen A, Fisher E, Collinge J, FReJA (2004). Frontotemporal dementia linked to chromosome 3.. Dement Geriatr Cogn Disord, 17(4), 274 - 276. doi:10.1159/000077153
    • Lloyd SE, Thompson SR, Beck JA, Linehan JM, Wadsworth JD, Brandner S, Collinge J, Fisher EMC (2004). Identification and characterization of a novel mouse prion gene allele.. Mamm Genome, 15(5), 383 - 389. doi:10.1007/s00335-004-3041-5
    • Kristiansen M, Klohn PC, Messenger MJ, Sutton LM, Podesta JE, Collinge J, Tabrizi SJ (2004). Prion infection renders neuronal cells more susceptible to proteasome inhibition and apoptotic stimuli.
    • Tabrizi SJ, Beck JA, Poulter M, Campbell T, Uphill JB, Adamson G, Geddes JF, Revesz T, Davis M, Wood N, Collinge J (2004). Somatic mosaicism in sporadic early-onset Alzheimer's disease.
    • Lloyd SE, Linehan JM, Desbruslais M, Joiner S, Buckell J, Brandner S, Wadsworth JD, Collinge J (2004). Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice. Journal of General Virology, 85(8), 2471 - 2478.
    • Hafezparast M, Brandner S, Linehan J, Martin JE, Collinge J, Fisher EMC (2004). Prion disease incubation time is not affected in mice heterozygous for a dynein mutation. Biochemical and Biophysical Research Communications, 326(1), 18 - 22.

    2003

    • Hill AF, Collinge J (2003). Subclinical prion infection in humans and animals.. Br Med Bull, 66, 161 - 170.
    • Hill AF, Collinge J (2003). Subclinical prion infection. In Rappocciolo E (Ed.), Trends in microbiology (pp. 578 - 584). : Oxford University Press.
    • Collinge J, Brandner S, Kennedy A, Rossor M, Smith P, Stevens J, Rudge P (2003). A 38-year-old man with a 9 month history of neurological and cognitive impairment. The Lancet Neurology, 2(3), 189 - 194.
    • White AR, Enever P, Tayebi M, Mushens R, Linehan J, Brandner S, Anstee D, Collinge J, Hawke S (2003). Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature, 422(6927), 80 - 83. doi:10.1038/nature01457
    • Johannsen P, Gydesen S, Brown J, Gade A, Chakrabarti L, Skibinski G, Englund E, Brun A, Rossor M, Soerensen SA, Fisher E, Collinge J (2003). Chromosome 3 related frontotemporal dementia. INT PSYCHOGERIATR, 15, 81 - 81.
    • MEDICAL RESEARCH COUNCIL, Jackson GS, Collinge J (2003). Method for determining susceptibility to prion disease.
    • MEDICAL RESEARCH COUNCIL, Jackson GS, Collinge J, Wadsworth JDF, Clarke AR, Hawke S (2003). Sarcosyl buffer and its use for the purification of prion protein.
    • Mead S, Stumpf MP, Whitfield J, Beck JA, Poulter M, Campbell T, Uphill JB, Goldstein D, Alpers M, EMC F, Collinge J (2003). Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics.. Science, 300(5619), 640 - 643. doi:10.1126/science.1083320
    • Hill AF, Collinge J (2003). Subclinical prion infection. Trends in Microbiology, 11(12), 578 - 584.
    • Mallucci G, Dickinson A, Linehan J, Klohn PC, Brandner S, Collinge J (2003). Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science, 302(5646), 871 - 874. doi:10.1126/science.1090187
    • Beringue V, Mallinson G, Kaisar M, Tayebi M, Sattar Z, Jackson G, Anstee D, Collinge J, Hawke S (2003). Regional heterogeneity of cellular prion protein isoforms in the mouse brain.. Brain, 126(Pt 9), 2065 - 2073. doi:10.1093/brain/awg205
    • Mead S, Heckmann J, Rutherfoord S, Poulter M, Collinge J (2003). Inherited prion disease caused by octapeptide repeat insertion: Genetic modifiers and haplotype background in large UK and South African families.
    • Ratte S, Collinge J, Jefferys JGR (2003). AMPA/KA receptor independent epileptiform bursts in the hippocampus of a mouse model of variant CJD.
    • McKintosh E, Tabrizi SJ, Collinge J (2003). Prion diseases. Journal of Neurovirology, 9(2), 183 - 193.
    • Hill AF, Joiner S, Wadsworth JD, Sidle KC, Bell JE, Budka H, Ironside JW, Collinge J (2003). Molecular classification of sporadic Creutzfeldt-Jakob disease.. Brain, 126(Pt 6), 1333 - 1346.
    • King A, Doey L, Rossor M, Mead S, Collinge J, Lantos P (2003). Phenotypic variability in the brains of a family with a prion disease characterized by a 144-base pair insertion in the prion protein gene.. Neuropathol Appl Neurobiol, 29(2), 98 - 105.
    • Janssen JC, Beck JA, Campbell TA, Dickinson A, Fox NC, Harvey RJ, Houlden H, Rossor MN, Collinge J (2003). Early onset familial Alzheimer's disease: Mutation frequency in 31 families.. Neurology, 60(2), 235 - 239.
    • Orth M, Tabrizi SJ (2003). Models of Parkinson's disease.. Mov Disord, 18(7), 729 - 737. doi:10.1002/mds.10447
    • Wadsworth JD, Hill AF, Beck JA, Collinge J (2003). Molecular and clinical classification of human prion disease.. Br Med Bull, 66, 241 - 254.
    • Tabrizi SJ, Collinge J (2003). Transmissable spongiform encephalopathies of humans and animals. In Cohen J, Powderly WG (Ed.), Infectious diseases (pp. 297 - 305). : Mosby.

    2002

    • Makrinou E, Antoniou M, Collinge J, Collinge J (2002). Genomic characterisation of the human prion protein (PrP) gene locus.
    • Hill AF, Collinge J (2002). Strain variations and species barriers. In (Ed.), Prions - A challenge for science, medicine and public health systems (pp. 48 - 57). : Basel: Karger.
    • Makrinou E, Collinge J, Antoniou M (2002). Genomic characterization of the human prion protein (PrP) gene locus. Mammalian Genome, 13(12), 696 - 703.
    • La Bella V, Collinge J, Pocchiari M, Piccoli F (2002). Variant Creutzfeldt-Jakob disease in an Italian woman. The Lancet, 360(9338), 997 - 998.
    • Joiner S, Linehan J, Brandner S, Wadsworth JD, Collinge J (2002). Irregular presence of abnormal prion protein in appendix in variant Creutzfeldt-Jakob disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 73(5), 597 - 598.
    • Hill AF, Collinge J (2002). Species-barrier-independent prion replication in apparently resistant species. Apmis, 110(1), 44 - 53.
    • Asante EA, Linehan JM, Desbruslais M, Joiner S, Gowland I, Wood AL, Welch J, Hill AF, Lloyd SE, Wadsworth JD, Collinge J (2002). BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. The EMBO Journal, 21(23), 6358 - 6366.
    • Mead S, Mahal S, Beck J, Farall M, Fisher EMC, Collinge J (2002). Identification of new prion disease susceptibility loci. J NEUROL NEUROSUR PS, 73(2), 223 - 223.
    • Janssen JC, Beck JA, Campbell TA, Dickinson A, Fox NC, Harvey RJ, Houlden H, Rosser MN, Collinge J (2002). Early onset familial alzheimer's disease: Mutation frequency in 31 families. J NEUROL NEUROSUR PS, 73(2), 219 - 219.
    • Janssen JC, Fox NC, Harvey RJ, Houlden H, Rossor MN, Beck JA, Campbell TA, Dickinson A, Collinge J (2002). Early-onset familial Alzheimer's disease: Mutation frequency in 31 families. NEUROBIOL AGING, 23(1), S311 - S311.
    • Collinge J (2002). Molecular pathology of human prion disease. NEUROBIOL AGING, 23(1), S428 - S428.
    • Collinge J, Wadsworth J (2002). Distribution of infectivity in variant Creutzfeldt-Jakob disease - Reply. LANCET, 359(9308), 801 - 801.
    • Mallucci GR, Ratte S, Asante EA, Linehan J, Gowland I, Jefferys JGR, Collinge J (2002). Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration (vol 21, pg 202, 2002). EMBO J, 21(5), 1240 - 1240.
    • Asante EA, Gowland I, Linehan JM, Mahal SP, Collinge J (2002). Expression pattern of a mini human PrP gene promoter in transgenic mice.. Neurobiol Dis, 10(1), 1 - 7.
    • Gydesen S, Brown JM, Brun A, Chakrabarti L, Gade A, Johannsen P, Rossor M, Thusgaard T, Grove A, Yancopoulou D, Spillantini MG, EMC F, Collinge J, Sorensen SA (2002). Chromosome 3 linked frontotemporal dementia (FTD-3).. Neurology, 59(10), 1585 - 1594.
    • Mallucci GR, Ratte S, Asante EA, Linehan J, Gowland I, Jefferys JGR, Collinge J (2002). Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. The EMBO Journal, 21(3), 202 - 210.
    • O'Riordan S, McMonagle P, Janssen JC, Fox NC, Farrell M, Collinge J, Rossor MN, Hutchinson M (2002). Presenilin-1 mutation (E280G), spastic paraparesis, and cranial MRI whitematter abnormalities. Neurology, 59(7), 1108 - 1110.
    • Lloyd SE, Uphill JB, Targonski PV, Fisher EM, Collinge J (2002). Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice. Neurogenetics, 4(2), 77 - 81.

    2001

    • Sattar Z, Tayebi M, Kaisar M, Khalili-Shirazi A, Mallinson G, Jackson GS, Collinge J, Hawke S (2001). PrP conformation and genotype profoundly influence anti-PrP antibody specificity.
    • Hill AF, Collinge J (2001). Strain variations and species barriers.. Contrib Microbiol, 7, 48 - 57.
    • Mead S, Mahal SP, Beck J, Campbell T, Farrall M, Fisher EMC, Collinge J (2001). Sporadic - but not variant - Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP Exon 1. AM J HUM GENET, 69(6), 1225 - 1235. doi:10.1086/324710
    • Janssen JC, Lantos PL, Fox NC, Harvey RJ, Beck J, Dickinson A, Campbell TA, Collinge J, Hanger DP, Cipolotti L, Stevens JM, Rossor MN (2001). Autopsy-confirmed familial early-onset Alzheimer disease caused by the L153V presenilin 1 mutation. Archives of Neurology, 58(6), 953 - 958.
    • Lloyd SE, Onwuazor ON, Beck JA, Mallinson G, Farrall M, Targonski P, Collinge J, Fisher EMC (2001). Identification of multiple quantitative trait loci linked to prion disease incubation period in mice.. Proceedings of the National Academy of Sciences of the United States of America, 98, 6279 - 6283. doi:10.1073/pnas.101130398
    • Mahal SP, Asante EA, Antoniou M, Collinge J (2001). Isolation and functional characterisation of the promoter region of the human prion protein gene.. Gene, 268(1-2), 105 - 114.
    • Jackson GS, Collinge J (2001). The molecular pathology of CJD: old and new variants.. Mol Pathol, 54(6), 393 - 399.
    • Jackson GS, Murray I, Hosszu LL, Gibbs N, Waltho JP, Clarke AR, Collinge J (2001). Location and properties of metal-binding sites on the human prion protein. Proceedings of the National Academy of Sciences of the United States of America, 98(15), 8531 - 8535. doi:10.1073/pnas.151038498
    • Murphy LM, Hasnain SS, Strange RW, Grossmann JG, Clarke AR, Jackson GS, Collinge J (2001). A new copper binding site in N-terminal truncated recombinant human PrP91-231. J INORG BIOCHEM, 86(1), 351 - 351.
    • Kulczycki J, Collinge J, Lojkowska W, Parnowski T, Wierzba-Bobrowicz T (2001). Report on the first polish case of the Gerstmann-Sträussler-Scheinker syndrome.. Folia Neuropathol, 39(1), 27 - 31.
    • Asante EA, Collinge J (2001). Transgenic studies of the influence of the PrP structure on TSE diseases.. Adv Protein Chem, 57, 273 - 311.
    • Collinge J (2001). Prion diseases of humans and animals: their causes and molecular basis.. Annu Rev Neurosci, 24, 519 - 550. doi:10.1146/annurev.neuro.24.1.519
    • Jackson GS, Beck JA, Navarrete C, Brown J, Sutton PM, Contreras M, Collinge J (2001). HLA-DQ7 antigen and resistance to variant CJD. Nature, 414(6861), 269 - 270.
    • Pepys MB, Caughey B, Kelly JW, Ellis RJ, Collinge J, Perutz MF, Masel J (2001). Prion protein interconversions - Discussion. PHILOS T R SOC B, 356(1406), 200 - 202.
    • Pepys HB, Collinge J, Barron LD, Collinge J, Masel J, Tahari-Alaoui A, Lansbury P, Exley C, Feizi T (2001). The molecular biology of prion propagation - Discussion. PHILOS T R SOC B, 356(1406), 194 - 195.
    • Clarke AR, Jackson GS, Collinge J (2001). The molecular biology of prion propagation. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 356(1406), 185 - 194.
    • Wadsworth JD, Joiner S, Hill AF, Campbell TA, Desbruslais M, Luthert PJ, Collinge J (2001). Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. The Lancet, 358(9277), 171 - 180. doi:10.1016/S0140-6736(01)05403-4
    • Beck JA, Mead S, Campbell TA, Dickinson A, Wientjens DP, Croes EA, Van Duijn CM, Collinge J (2001). Two-octapeptide repeat deletion of prion protein associated with rapidly progressive dementia.. Neurology, 57(2), 354 - 356.
    • Imperial College Innovations LTD, Collinge J, Clarke AR, Waltho JP, Jackson GS, Hosszu LLP (2001). Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases.
    • Jackson GS, Beck JA, Navarrete C, Brown J, Sutton PM, Contreras M, Collinge J (2001). Pathogenesis - HLA-DQ7 antigen and resistance to variant CJD. NATURE, 414(6861), 269 - 270.
    • Flechsig E, Hegyi I, Enari M, Schwarz P, Collinge J, Weissmann C (2001). Transmission of scrapie by steel-surface-bound prions.. Mol Med, 7(10), 679 - 684.
    • Makrinou E, Collinge J, Antoniou M (2001). Genomic characterisation of the human PRNP/PRND locus.. AM J HUM GENET, 69(4), 369 - 369.
    • Mead SH, Mahal SP, Farrall M, Fisher EMC, Collinge J (2001). Association of prion protein gene single nucleotide polymorphism haplotypes with Creutzfeldt-Jakob disease.. AM J HUM GENET, 69(4), 182 - 182.
    • Hasnain SS, Murphy LM, Strange RW, Grossmann JG, Clarke AR, Jackson GS, Collinge J (2001). XAFS study of the high-affinity copper-binding site of human PrP(91-231) and its low-resolution structure in solution.. J Mol Biol, 311(3), 467 - 473. doi:10.1006/jmbi.2001.4795

    2000

    • Jackson GS, Collinge J (2000). Prion disease - the propagation of infectious protein topologies. MICROBES INFECT, 2(12), 1445 - 1449.
    • Janssen JC, Hall M, Fox NC, Harvey RJ, Beck J, Dickinson A, Campbell T, Collinge J, Lantos PL, Cipolotti L, Stevens JM, Rossor MN (2000). Alzheimer's disease due to an intronic presenilin-1 (PSEN1 intron 4) mutation: a clinicopathological study. Brain, 123, 894 - 907.
    • Collinge J (2000). Prion diseases. In Ledingham JGG, Warrell DA (Ed.), Concise Oxford textbook of medicine (pp. 1307 - 1311). : Oxford University Press.
    • Collinge J (2000). Creutzfeldt-Jakob disease and other prion diseases. In O'Brien JT, Ames D, Burns A (Ed.), Dementia (pp. - ). : Hodder Arnold.
    • Barrow PA, Mallucci G, Collinge J, Jefferys JGR (2000). Rescue of a physiological phenotype in mice with ablated PrP gene but expressing a transgene cassette for PrP. J PHYSIOL-LONDON, 523, 203P - 204P.
    • Mead S, Beck J, Dickinson A, Fisher E, Collinge J (2000). Examination of the human prion protein-like gene doppel for genetic susceptibility to sporadic and variant Creutzfeldt-Jakob disease.. Neuroscience Letters, 290(2), 117 - 120.
    • King A, Rossor M, Doey L, Collinge J, Lantos P (2000). Phenotypic variations in a familiar prion disease characterised by a 144 base pair insertion in the Prion protein gene. BRAIN PATHOL, 10(4), 669 - 669.
    • D-GEN LTD, Collinge J, Clarke AR, Jackson GS (2000). Biological materials and methods useful in the diagnosis and treatment of prion diseases.
    • Collinge J (2000). Human prion diseases. BRAIN PATHOL, 10(4), 607 - 607.
    • D-GEN LTD, Collinge J, Wadsworth JDF, Thomas PJD (2000). Method to type prion proteins.
    • Hill AF, Joiner S, Linehan J, Desbruslais M, Lantos PL, Collinge J (2000). Species-barrier-independent prion replication in apparently resistant species.. Proc Natl Acad Sci U S A, 97(18), 10248 - 10253.

    1999

    • Almer G, Hainfellner JA, Brücke T, Jellinger K, Kleinert R, Bayer G, Windl O, Kretzschmar HA, Hill A, Sidle K, Collinge J, Budka H (1999). Fatal familial insomnia: a new Austrian family.. Brain, 122 ( Pt 1), 5 - 16.
    • Hill AF, Antoniou M, Collinge J (1999). Protease-resistant prion protein produced in vitro lacks detectable infectivity.. J Gen Virol, 80 ( Pt 1), 11 - 14.
    • Telling GC, Collinge J (1999). Transmissible spongiform encephalopathies of humans and animals. In Armstrong D, Cohen J (Ed.), Central nervous system (pp. 191 - 195). : Mosby International.
    • Mallucci GR, Campbell TA, Dickinson A, Beck J, Holt M, Plant G, de Pauw KW, Hakin RN, Clarke CE, Howell S, Davies-Jones GA, Lawden M, Smith CM, Ince P, Ironside JW, Bridges LR, Dean A, Weeks I, Collinge J (1999). Inherited prion disease with an alanine to valine mutation at codon 117 in the prion protein gene.. Brain, 122 ( Pt 10), 1823 - 1837.
    • Hosszu LL, Baxter NJ, Jackson GS, Power A, Clarke AR, Waltho JP, Craven CJ, Collinge J (1999). Structural mobility of the human prion protein probed by backbone hydrogen exchange.. Nat Struct Biol, 6(8), 740 - 743. doi:10.1038/11507
    • Collinge J (1999). Variant Creutzfeldt-Jakob disease.. Lancet, 354(9175), 317 - 323. doi:10.1016/S0140-6736(99)05128-4
    • Wadsworth JD, Jackson GS, Hill AF, Collinge J (1999). Molecular biology of prion propagation.. Curr Opin Genet Dev, 9(3), 338 - 345.
    • Wadsworth JD, Hill AF, Joiner S, Jackson GS, Clarke AR, Collinge J (1999). Strain-specific prion-protein conformation determined by metal ions.. Nat Cell Biol, 1(1), 55 - 59. doi:10.1038/9030
    • Jackson GS, Hill AF, Joseph C, Hosszu L, Power A, Waltho JP, Clarke AR, Collinge J (1999). Multiple folding pathways for heterologously expressed human prion protein.. Biochim Biophys Acta, 1431(1), 1 - 13.
    • Jackson GS, Hosszu LL, Power A, Hill AF, Kenney J, Saibil H, Craven CJ, Waltho JP, Clarke AR, Collinge J (1999). Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.. Science, 283(5409), 1935 - 1937.
    • Hill AF, Butterworth RJ, Joiner S, Jackson G, Rossor MN, Thomas DJ, Frosh A, Tolley N, Bell JE, Spencer M, King A, Al Sarraj S, Ironside JW, Lantos PL, Collinge J (1999). Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. The Lancet, 353, 183 - 189.
    • Ashworth A, Lloyd S, Brown J, Gydesen S, Sorensen SA, Brun A, Englund E, Humphreys C, Housman D, Badura M, Stanton V, Taylor K, Cameron J, Munroe D, Johansson J, Rossor M, Fisher EMC, Collinge J (1999). Molecular genetic characterisation of frontotemporal dementia on chromosome 3. Dementia and Geriatric Cognitive Disorders, 10(Suppl.1), 93 - 101.
    • Palmer MS, Beck JA, Campbell TA, Humphries CB, Roques PK, Fox NC, Harvey R, Rossor MN, Collinge J (1999). Pathogenic presenilin 1 mutations (P436S & I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223. Online.. Hum Mutat, 13(3), 256 - . doi:10.1002/(SICI)1098-1004(1999)13:3<256::AID-HUMU12>3.0.CO;2-M

    1998

    • Collinge J, Hawke S (1998). B lymphocytes in prion neuroinvasion: central or peripheral players?. Nat Med, 4(12), 1369 - 1370. doi:10.1038/3955
    • Fisher E, Telling G, Collinge J (1998). Prions and the prion disorders.. Mamm Genome, 9(7), 497 - 502.
    • Piccardo P, Langeveld JP, Hill AF, Dlouhy SR, Young K, Giaccone G, Rossi G, Bugiani M, Bugiani O, Meloen RH, Collinge J, Tagliavini F, Ghetti B (1998). An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.. Am J Pathol, 152(6), 1415 - 1420.
    • Brett FM, Cervenakova L, Collinge J, Farrell MA, Gibbs CJ, Traynor B, Staunton H (1998). Sporadic fatal dementia with thalamic gliosis and D178N PrP genotype but with absence of spongiform change and negative PrP immunocytochemistry.. J NEUROPATH EXP NEUR, 57(5), 492 - 492.
    • Sidle K, Will B, Lantos P, Collinge J (1998). Transmission studies of fatal familial insomnia.
    • Collinge J (1998). Assessing risks of BSE transmission to humans.
    • Collinge J, Beck J, Campbell TA, Desbuslais M, Gowland I, Hill A, Mahal S, Meads J, Sidle KCL, Jefferys JGR (1998). Molecular, genetic and transgenetic studies of human prion disease.
    • Jackson GS, Hill A, Joseph C, Clarke AR, Collinge J (1998). Structural properties of recombinant human prion protein. In Morrison DO (Ed.), Prions and brain diseases in animals and humans. (pp. 197 - 202). : Plenum.
    • Hill AF, Sidle KC, Joiner S, Keyes P, Martin TC, Dawson M, Collinge J (1998). Molecular screening of sheep for bovine spongiform encephalopathy.. Neurosci Lett, 255(3), 159 - 162.
    • Collinge J, Rossor MN, Thomas D, Frosh A, Tolley N (1998). Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum - Tonsil biopsy helps diagnose new variant Creutzfeldt-Jakob disease. BRIT MED J, 317(7156), 472 - 472.
    • Harvey RJ, Ellison D, Hardy J, Hutton M, Rogues P, Collinge J, Fox NC, Rossor MN (1998). Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine->serine (L250S) substitution at codon 250 of the presenilin 1 gene. Journal of Neurology, Neurosurgery and Psychiatry, 64, 44 - 49.
    • Alvarez XA, Barker S, Binetti G, Boller F, Bracco L, Breteler M, Brun A, Cacabelos R, Caims N, Cappa S, Cipolotti L, Collinge J, Englund E, Forleo P, Forstl H, Grassi E, Harvey R, Hodges J, Gustafson L, Kurz A, Lantos P, Lautenschlager N, Lebert F, Muggia S, Pasquier F, Passant U, Ravid R, Rossor M, Sorbi S, Spinnler H, Stevens J, Van Swieten J, Warrington E, Xuereb J (1998). Provisional clinical and neuroradiological criteria for the diagnosis of Pick's disease. European Journal of Neurology, 5, 519 - 520.
    • Jackson G, Hill A, Joseph C, Clarke A, Collinge J (1998). Structural properties of recombinant human prion protein.
    • Collinge J (1998). Human prion diseases: Aetiology and clinical features. In Growdon JH, Rossor M (Ed.), The dementias (pp. 113 - 148). : Newton, Butterworth-Heinemann.

    1997

    • Collinge J, Palmer MS, Sidle KCL, Hill AF, Gowland I, Meads J, Asante E, Bradley R, Doey LJ, Lantos PL (1997). Unaltered susceptibility to BSE in transgenic mice expressing human prion protein (vol 378, pg 779, 1995). NATURE, 389(6650), 526 - 526.
    • Fox NC, Kennedy AM, Harvey RJ, Lantos PL, Roques P, Collinge J, Hardy J, Hutton M, Stevens JM, Warrington EK, Rossor MN (1997). Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene - pedigree but not mutation specific age at onset provides evidence for a further genetic factor. Brain, 120, 491 - 501.
    • Piccardo P, Tagliavini F, Dlouhy SR, Young K, Seiler C, Rossi G, Hill AF, Bugiani M, Bugiani O, Langeveld JPM, Collinge J, Ghetti B (1997). Species and disease specific prion protein (PrP) isoforms are detected by antibodies (abs) raised against a highly conserved mid-region sequence. BRAIN PATHOL, 7(4), 1248 - 1248.
    • Budka H, Hainfellner JA, Almer G, BrOcke T, Windl O, Kretzschmar HA, Hill A, Collinge J (1997). A new Austrian family with fatal familial insomnia: Brain pathology without detectable PrPres. BRAIN PATHOL, 7(4), 1267 - 1267.
    • Lantos PL, Bhatia K, Doey LJ, al-Sarraj S, Doshi R, Beck J, Collinge J (1997). Is the neuropathology of new variant Creutzfeldt-Jakob disease and kuru similar?. Lancet, 350(9072), 187 - 188.
    • Hill AF, Will RG, Ironside J, Collinge J (1997). Type of prion protein in UK farmers with Creutzfeldt-Jakob disease. LANCET, 350(9072), 188 - 188.
    • Collinge J, Hill AF, Ironside J, Zeidler M (1997). Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy - Reply. LANCET, 349(9061), 1323 - 1323.
    • Basun H, Almkvist O, Axelman K, Brun A, Campbell TA, Collinge J, Forsell C, Froelich S, Wahlund LO, Wetterberg L, Lannfelt L (1997). Clinical characteristics of a chromosome 17-linked rapidly progressive familial frontotemporal dementia.. Arch Neurol, 54(5), 539 - 544.
    • Piccardo P, Tagliavini F, Dlouhy SR, Young K, Seiler C, Rossi G, Hill AF, Bugiani O, Collinge J, Ghetti B (1997). An antiserum to residues 95-108 of human PrP detects PrPres in a variety of human and animal prion diseases.. J NEUROPATH EXP NEUR, 56(5), 73 - 73.
    • Colling SB, Khana M, Collinge J, Jefferys JG (1997). Mossy fibre reorganization in the hippocampus of prion protein null mice.. Brain Res, 755(1), 28 - 35.
    • Collinge J, Hill AF, Sidle KCL, Ironside J (1997). Biochemical typing of scrapie strains - Reply. NATURE, 386(6625), 564 - 564.
    • Smith CJ, Drake AF, Banfield BA, Bloomberg GB, Palmer MS, Clarke AR, Collinge J (1997). Conformational properties of the prion octa-repeat and hydrophobic sequences.. FEBS Lett, 405(3), 378 - 384.
    • Collinge J, Hill AF, Sidle KCL, Ironside J (1997). Typing prion isoforms - Reply. NATURE, 386(6622), 233 - 234.
    • Esiri MM, Gordon WI, Collinge J, Patten JS (1997). Peripheral neuropathy in Creutzfeldt-Jakob disease. NEUROLOGY, 48(3), 784 - 784.
    • Hill AF, Zeidler M, Ironside J, Collinge J (1997). Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy.. Lancet, 349(9045), 99 - 100. doi:10.1016/S0140-6736(97)24002-X
    • Deslys JP, Lasmézas CI, Streichenberger N, Hill A, Collinge J, Dormont D, Kopp N (1997). New variant Creutzfeldt-Jakob disease in France.. Lancet, 349(9044), 30 - 31.
    • Collinge J (1997). Human prion diseases and bovine spongiform encephalopathy (BSE).. Hum Mol Genet, 6(10), 1699 - 1705.
    • Mallucci GR, Collinge J (1997). Neuropsychiatric presentations of prion disease. CURR OPIN PSYCHIATR, 10(1), 59 - 62.
    • Collinge J (1997). Assessing risks of BSE transmission to humans. In Goebel K (Ed.), International seminar on nuclear war and planetary emergencies (pp. 54 - 54). : World Scientific.
    • Hill AF, Desbruslais M, Joiner S, Sidle KCL, Gowland I, Collinge J, Doey LJ, Lantos P (1997). The same prion strain causes vCJD and BSE. NATURE, 389(6650), 448 - 450.
    • Aguzzi A, Collinge J (1997). Post-exposure prophylaxis after accidental prion inoculation.. Lancet, 350(9090), 1519 - 1520. doi:10.1016/S0140-6736(05)63941-4
    • Lachmann P, Allen I, Anderson R, Biggs P, Bostock C, Collinge J, Heap B, Kimberlin R, Klug A, Raff M, Swales J, Southwood R, Wilesmith J, Will B, Weissman C (1997). Update on BSE. INTERDISCIPL SCI REV, 22(3), 181 - 186.
    • Budka H, Hainfellner JA, Jellinger K, Kleinert R, Maier H, Pilz P, Sciot R, Martin JJ, BojsenMoller M, Laursen H, StTeglbjaerg P, Haltia M, Kovanen J, Delisle MB, Dormont D, Lasmezas C, Gray F, Hauw JJ, Seilhean D, Heldt N, Mikol J, Vital C, Foncin JF, ElHachimi K, Kopp N, Bergmann M, Bilzer T, CervosNavarro J, Diringer H, Feiden W, Goebel HH, Bohl J, Gullotta F, Jendroska K, Kretzschmar HA, Linke RP, Meyermann R, Boellaard JW, Mehraein P, Schlote W, Schroder JM, Schroder R, Volk B, Walter GF, Hori A, Wiestler OD, Balloyannis SJ, Davaki P, Patsouris E, Georgsson G, Farrell M, Keohane C, Bugiani O, Macchi G, Masullo C, Costanzi G, Pocchiari M, Rizzutto N, Schiffer D, Trabattoni GR, Giangaspero F, Jansen GH, Grinde B, Mork SJ, Skullerud K, Lima C, Pimentel J, CruzSanchez FF, Berciano JA, MartinezLage J, Navarro C, Cabello A, Brun A, Kristensson K, Lundberg PO, Olsson Y, Collinge J, Esiri MM, Graham D, Ironside JW, Lantos PL, MacKenzie JM, Scaravilli F, Weller RO, Will RG, Allen IV, Mirakhur M, Majtenyi K, Liberski PP, Petrescu A, Mitrova E, Popovic M, Aguzzi A, Janzer RC, Pizzolato G, Stamm B, Vandevelde M, Masters CL, Tateishi J, Kitamoto T, Brown P (1997). The human prion diseases: from neuropathology to pathobiology and molecular genetics - Final report of an EU Concerted Action. NEUROPATH APPL NEURO, 23(5), 416 - 422.

    1996

    • Collinge J, Sidle KC, Meads J, Ironside J, Hill AF (1996). Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.. Nature, 383(6602), 685 - 690. doi:10.1038/383685a0
    • Collinge J (1996). New diagnostic tests for prion diseases.. N Engl J Med, 335(13), 963 - 965. doi:10.1056/NEJM199609263351310
    • Windl O, Dempster M, Estibeiro JP, Lathe R, de Silva R, Esmonde T, Will R, Springbett A, Campbell TA, Sidle KC, Palmer MS, Collinge J (1996). Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene.. Hum Genet, 98(3), 259 - 264.
    • Collinge J, Beck J, Campbell T, Estibeiro K, Will RG (1996). Prion protein gene analysis in new variant cases of Creutzfeldt-Jakob disease. LANCET, 348(9019), 56 - 56.
    • Colling SB, Collinge J, Jefferys JG (1996). Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents.. Neurosci Lett, 209(1), 49 - 52.
    • Campbell TA, Palmer MS, Will RG, Gibb WR, Luthert PJ, Collinge J (1996). A prion disease with a novel 96-base pair insertional mutation in the prion protein gene.. Neurology, 46(3), 761 - 766.
    • Tabrizi SJ, Scaravilli F, Howard RS, Collinge J, Rossor MN (1996). Creutzfeldt-Jakob disease in a young woman.. The Lancet, 347(9006), 945 - 948.
    • Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Kretzschmar HA, Lantos PL, Masullo C, Pocchiari M, Schlote W, Tateishi J, Will RG (1996). Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). PATHOLOGE, 17(2), 171 - 175.
    • Palmer MS, van Leeven RH, Mahal SP, Campbell TA, Humphreys CB, Collinge J (1996). Sequence variation in intron of prion protein gene, crucial for complete diagnostic strategies.. Hum Mutat, 7(3), 280 - 281. doi:10.1002/(SICI)1098-1004(1996)7:3<280::AID-HUMU17>3.0.CO;2-Z
    • Collinge J (1996). Prion diseases. In Weatherall DJ, Ledingham J, Warrell D (Ed.), Oxford textbook of medicine (pp. 3977 - 3981). : Oxford University Press.
    • Rossor MN, Fox NC, Beck J, Campbell TC, Collinge J (1996). Incomplete penetrance of familial Alzheimer's disease in a pedigree with a novel presenilin-1 gene mutation. LANCET, 347(9014), 1560 - 1560.
    • Collinge J, Rossor M (1996). A new variant of prion disease.. Lancet, 347(9006), 916 - 917.
    • Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Kretzschmar HA, Lantos PL, Masullo C, Pocchiari M, Schlote W, Tateishi J, Will RG (1996). [Consensus report: tissue handling in suspected Creutzfeldt-Jakob disease and other spongiform encephalopathies (prion diseases) in the human. European Union Biomed-1 Concerted Action].. Pathologe, 17(2), 171 - 175.

    1995

    • Whittington MA, Sidle KC, Gowland I, Meads J, Hill AF, Palmer MS, Jefferys JG, Collinge J (1995). Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein.. Nat Genet, 9(2), 197 - 201. doi:10.1038/ng0295-197
    • MULLAN M, BENNETT C, FIGUEREDO C, HUGHES D, MANT R, OWEN M, WARREN A, MCINNIS M, MARSHALL A, LANTOS P, COLLINGE J, GOATE A, HOULDEN H, CRAWFORD F (1995). CLINICAL-FEATURES OF EARLY-ONSET, FAMILIAL ALZHEIMERS-DISEASE LINKED TO CHROMOSOME-14. AM J MED GENET, 60(1), 44 - 52.
    • Collinge J (1995). Molecular genetics of human prion disease and the development of transgenic models. In Prusiner SB (Ed.), Current topics in microbiology and immunology (pp. 35 - 36). : Scientific Publishing Services (P) Ltd.
    • Collinge J, Palmer MS, Sidle KC, Hill AF, Gowland I, Meads J, Asante E, Bradley R, Doey LJ, Lantos PL (1995). Unaltered susceptibility to BSE in transgenic mice expressing human prion protein.. Nature, 378(6559), 779 - 783. doi:10.1038/378779a0
    • Britton TC, al-Sarraj S, Shaw C, Campbell T, Collinge J (1995). Sporadic Creutzfeldt-Jakob disease in a 16-year-old in the UK.. Lancet, 346(8983), 1155 - .
    • Collinge J, Palmer MS, Sidle KC, Gowland I, Medori R, Ironside J, Lantos P (1995). Transmission of fatal familial insomnia to laboratory animals.. Lancet, 346(8974), 569 - 570.
    • YULUG IG, KATSANIS N, DEBELLEROCHE J, COLLINGE J, FISHER EMC (1995). AN IMPROVED PROTOCOL FOR THE ANALYSIS OF SOD1 GENE-MUTATIONS, AND A NEW MUTATION IN EXON-4 (VOL 4, PG 1101, 1995). HUM MOL GENET, 4(8), 1474 - 1474.
    • Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gullotta F, Haltia M, Hauw JJ (1995). Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol, 5(3), 319 - 322.
    • Yulug IG, Katsanis N, de Belleroche J, Collinge J, Fisher EM (1995). An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon 4.. Hum Mol Genet, 4(6), 1101 - 1104.
    • WHITTINGTON MA, SIDLE KCL, GOWLAND I, MEADS J, HILL AF, PALMER MS, JEFFERYS JGR, COLLINGE J (1995). RESCUE OF NEUROPHYSIOLOGICAL PHENOTYPE SEEN IN PRP NULL MICE BY TRANSGENE ENCODING HUMAN PRION PROTEIN, (VOL 9, PG 197, 1995). NAT GENET, 9(4), 451 - 451.
    • Bateman D, Hilton D, Love S, Zeidler M, Beck J, Collinge J (1995). Sporadic Creutzfeldt-Jakob disease in a 18-year-old in the UK.. Lancet, 346(8983), 1155 - 1156.
    • ASHWORTH A, BROWN J, GYDESEN S, SORENSEN A, ROSSOR MN, HARDY J, PALMER MS, COLLINGE J (1995). A LOCUS FOR FAMILIAL NON SPECIFIC DEMENTIA MAPS TO CHROMOSOME-3. AM J HUM GENET, 57(4), 1063 - 1063.
    • CLARK RF, HUTTON M, FULDNER RA, FROELICH S, KARRAN E, TALBOT C, CROOK R, LENDON C, PRIHAR G, HE C, KORENBLAT K, MARTINEZ A, WRAGG M, BUSFIELD F, BEHRENS MI, MYERS A, NORTON J, MORRIS J, MEHTA N, PEARSON C, LINCOLN S, BAKER M, DUFF K, ZEHR C, PEREZTUR J, HOULDEN H, RUIZ A, OSSA J, LOPERA F, ARCOS M, MADRIGAL L, COLLINGE J, HUMPHREYS C, ASHWORTH A, SARNER S, FOX N, HARVEY R, KENNEDY A, ROQUES P, CLINE RT, PHILLIPS CA, VENTER JC, FORSELL L, AXELMAN K, LILIUS L, JOHNSTON J, COWBURN R, VIITANEN M, WINBLAD B, KOSIK K, HALTIA M, POYHONEN M, DICKSON D, MANN D, NEARY D, SNOWDEN J, LANTOS P, LANNFELT L, ROSSOR M, ROBERTS GW, ADAMS MD, HARDY J, GOATE A (1995). THE STRUCTURE OF THE PRESENILIN-1 (S182) GENE AND IDENTIFICATION OF 6 NOVEL MUTATIONS IN EARLY-ONSET AD FAMILIES. NAT GENET, 11(2), 219 - 222.
    • Ashworth A, Brown J, Gydesen S, Sorensen SA, Rossor MN, Hardy J, Collinge J (1995). Frontal lobe or 'nonspecific' dementias are genetically heterogeneous.. Neurology, 45(9), 1781 - .
    • Brown J, Ashworth A, Gydesen S, Sorensen A, Rossor M, Hardy J, Collinge J (1995). Familial non-specific dementia maps to chromosome 3.. Hum Mol Genet, 4(9), 1625 - 1628.
    • Houlden H, Crook R, Duff K, Hutton M, Collinge J, Roques P, Rossor M, Hardy J (1995). Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.. Neurosci Lett, 188(3), 202 - 204.
    • Smith C, Collinge J (1995). Molecular pathology of prion diseases.. Essays Biochem, 29, 157 - 174.

    1994

    • Telling GC, Scott M, Hsiao KK, Foster D, Yang SL, Torchia M, Sidle KC, Collinge J, DeArmond SJ, Prusiner SB (1994). Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.. Proc Natl Acad Sci U S A, 91(21), 9936 - 9940.
    • Ashworth A, Campbell T, Palmer M, Collinge J, Brown J (1994). G/T polymorphism in CRYA2 gene.. Hum Mol Genet, 3(9), 1712 - .
    • Collinge J, Palmer MS (1994). Human prion diseases.. Baillieres Clin Neurol, 3(2), 241 - 247.
    • Collinge J, Whittington MA, Sidle KC, Smith CJ, Palmer MS, Clarke AR, Jefferys JG (1994). Prion protein is necessary for normal synaptic function.. Nature, 370(6487), 295 - 297. doi:10.1038/370295a0
    • Collinge J, Palmer MS, Sidle KC, Mahal SP, Campbell T, Brown J, Hardy J, Brun AE, Gustafson L, Bakker E (1994). Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease.. J Neurol Neurosurg Psychiatry, 57(6), 762 - .
    • COLLINGE J (1994). MOLECULAR-BIOLOGY OF PRION DISEASES - PREFACE. PHILOS T ROY SOC B, 343(1306), 353 - 353.
    • Collinge J, Palmer MS (1994). Prion diseases. In Burns A, Levy R (Ed.), Dementia (pp. 835 - 853). : Chapman and Hall.
    • Collinge J, Palmer MS (1994). Human prion diseases. In Harding AE (Ed.), Genetics in Neurology (pp. 241 - 257). : Bailliere Tindall.
    • Houlden H, Crook R, Hardy J, Roques P, Collinge J, Rossor M (1994). Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus.. Neurosci Lett, 174(2), 222 - 224.
    • Collinge J, Palmer MS (1994). Molecular genetics of human prion diseases.. Philos Trans R Soc Lond B Biol Sci, 343(1306), 371 - 378. doi:10.1098/rstb.1994.0031

    1993

    • Palmer MS, Mahal SP, Campbell TA, Hill AF, Sidle KC, Laplanche JL, Collinge J (1993). Deletions in the prion protein gene are not associated with CJD.. Hum Mol Genet, 2(5), 541 - 544.
    • Collinge J, Palmer MS (1993). Prion diseases in humans and their relevance to other neurodegenerative diseases.. Dementia, 4(3-4), 178 - 185.
    • Collinge J, Palmer MS, Rossor MN, Janota I, Lantos PL (1993). Prion dementia.. Lancet, 341(8845), 627 - .
    • Collinge J, Palmer MS, Campbell T, Sidle KC, Carroll D, Harding A (1993). Inherited prion disease (PrP lysine 200) in Britain: two case reports.. BMJ, 306(6873), 301 - 302.
    • Weber T, Tumani H, Holdorff B, Collinge J, Palmer M, Kretzschmar HA, Felgenhauer K (1993). Transmission of Creutzfeldt-Jakob disease by handling of dura mater.. Lancet, 341(8837), 123 - 124.
    • Collinge J (1993). Inherited prion diseases. In Harding AE (Ed.), Advances in neurology: inherited ataxias (pp. 155 - 165). : Raven Press.
    • Collinge J (1993). Inherited prion diseases.. Adv Neurol, 61, 155 - 165.
    • HOULDEN H, CROOK R, DUFF K, COLLINGE J, ROQUES P, ROSSOR M, HARDY J (1993). CONFIRMATION THAT THE APOLIPOPROTEIN E4 ALLELE IS ASSOCIATED WITH LATE-ONSET, FAMILIAL ALZHEIMERS-DISEASE. NEURODEGENERATION, 2(4), 283 - 286.
    • HARDY J, HOULDEN H, COLLINGE J, KENNEDY A, NEWMAN S, ROSSOR M, LANNFELT L, LILIUS L, WINBLAD B, CROOK R, DUFF K (1993). APOLIPOPROTEIN-E GENOTYPE AND ALZHEIMERS-DISEASE. LANCET, 342(8873), 737 - 738.
    • Brown J, Gydesen S, Sorensen SA, Brun A, Smith S, Houlden H, Twells R, Mullan M, Rossor M, Collinge J (1993). Genetic characterization of a familial non-specific dementia originating in Jutland, Denmark.. J Neurol Sci, 114(2), 138 - 143.
    • Palmer MS, Collinge J (1993). Mutations and polymorphisms in the prion protein gene.. Hum Mutat, 2(3), 168 - 173. doi:10.1002/humu.1380020303

    1992

    • Poulter M, Baker HF, Frith CD, Leach M, Lofthouse R, Ridley RM, Shah T, Owen F, Collinge J, Brown J (1992). Inherited prion disease with 144 base pair gene insertion. 1. Genealogical and molecular studies.. Brain, 115 ( Pt 3), 675 - 685.
    • Palmer MS, Collinge J (1992). Human prion diseases. In Rossor M (Ed.), Unusual dementias (pp. 627 - 651). : Bailliere Tindall.
    • ANDERTON B, COLLINGE J, POWELL J, PRUSINER SB (1992). AN INTRODUCTION TO PRION RESEARCH.
    • COLLINGE J, PRUSINER SB (1992). TERMINOLOGY OF PRION DISEASES.
    • CROW TJ, POULTER M, BAKER HF, FRITH CD, LEACH M, LOFTHOUSE R, RIDLEY RM, SHAH T, OWEN F, COLLINGE J, BROWN G, HARDY J, MULLAN MJ, HARDING AE, BENNETT C, DOSHI R (1992). FAMILIAL DEMENTIA IN RELATION TO THE 144 BP INSERT AND ITS IMPLICATIONS.
    • COLLINGE J, PRUSINER SB (1992). PRIONS AND NEURODEGENERATIVE DISEASES.
    • Collinge J, Prusiner SB (1992). Terminology of prion disease. In Prusiner SB, Collinge J, Powell J, Anderton B (Ed.), Prion diseases of humans & animals (pp. 5 - 12). : Ellis Horwood.
    • Collinge J, Palmer S (1992). Molecular genetics of inherited, sporadic and iatrogenic prion disease. In Prusiner SB, Collinge J, Powell J, Anderton B (Ed.), Prion diseases of humans and animals (pp. 95 - 119). : Ellis Horwood.
    • Anderton BH, Collinge J, Powell J, Prusiner SB (1992). An introduction to prion research. In Prusiner SB, Collinge J, Powell J, Anderton B (Ed.), Prion diseases of humans and animals (pp. 3 - 4). : Ellis Horwood.
    • Prusiner SB, Collinge J (1992). Prions and neurodegenerative diseases. In Prusiner SB, Collinge J, Powell J, Anderton B (Ed.), Prion diseases of humans & animals (pp. 568 - 569). : Ellis Horwood.
    • Crow TJ, Poulter M, Baker HF, Frith CD, Leach M, Lofthouse R, Ridley RM, Shah T, Owen F, Collinge J, Brown G, Hardy J, Mullan MJ, Harding AE, Bennett C, Doshi R (1992). Familial dementia in relation to the 144bp insert and its implications. In Prusiner SB, Collinge J, Powell J, Anderton B (Ed.), Prion diseases of humans & animals (pp. 200 - 214). : Ellis Horwood.
    • Palmer MS, Collinge J (1992). Human prion diseases.. Curr Opin Neurol Neurosurg, 5(6), 895 - 901.
    • Lantos PL, McGill IS, Janota I, Doey LJ, Collinge J, Bruce MT, Whatley SA, Anderton BH, Clinton J, Roberts GW (1992). Prion protein immunocytochemistry helps to establish the true incidence of prion diseases.. Neurosci Lett, 147(1), 67 - 71.
    • Palmer MS, Collinge J (1992). Human prion diseases.. Baillieres Clin Neurol, 1(3), 627 - 651.
    • Collinge J, Brown J, Hardy J, Mullan M, Rossor MN, Baker H, Crow TJ, Lofthouse R, Poulter M, Ridley R (1992). Inherited prion disease with 144 base pair gene insertion. 2. Clinical and pathological features.. Brain, 115 ( Pt 3), 687 - 710.
    • Collinge J, Palmer MS (1992). Prion diseases.. Curr Opin Genet Dev, 2(3), 448 - 454.
    • COLLINGE J, PALMER MS (1992). MOLECULAR-GENETICS OF INHERITED, SPORADIC AND IATROGENIC PRION DISEASE.
    • Owen F, Poulter M, Collinge J, Leach M, Lofthouse R, Crow TJ, Harding AE (1992). A dementing illness associated with a novel insertion in the prion protein gene.. Brain Res Mol Brain Res, 13(1-2), 155 - 157.

    1991

    • BROWN J, SMITH S, BRUN A, COLLINGE J, GYDESEN S, HARDY J, MULLAN M, GOATE A (1991). GENETIC-CHARACTERIZATION OF A NOVEL FAMILIAL DEMENTIA. ANN NY ACAD SCI, 640, 181 - 183.
    • Owen F, Poulter M, Collinge J, Leach M, Shah T, Lofthouse R, Chen YF, Crow TJ, Harding AE, Hardy J (1991). Insertions in the prion protein gene in atypical dementias.. Exp Neurol, 112(2), 240 - 242.
    • Collinge J, Poulter M, Davis MB, Baraitser M, Owen F, Crow TJ, Harding AE (1991). Presymptomatic detection or exclusion of prion protein gene defects in families with inherited prion diseases.. Am J Hum Genet, 49(6), 1351 - 1354.
    • Roberts GW, Collinge J (1991). Playing clue with prion disease.. Lab Invest, 65(6), 607 - 609.
    • COLLINGE J, PALMER M (1991). CJD DISCREPANCY - REPLY. NATURE, 353(6347), 802 - 802.
    • COLLINGE J (1991). SPONGIFORM ENCEPHALOPATHIES - REPLY. NEUROPATH APPL NEURO, 17(4), 346 - 346.
    • Palmer MS, Dryden AJ, Hughes JT, Collinge J (1991). Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease.. Nature, 352(6333), 340 - 342. doi:10.1038/352340a0
    • Collinge J, Palmer MS, Dryden AJ (1991). Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease.. Lancet, 337(8755), 1441 - 1442.
    • BAKER HF, POULTER M, CROW TJ, FRITH CD, LOFTHOUSE R, RIDLEY RM, COLLINGE J (1991). AMINO-ACID POLYMORPHISM IN HUMAN PRION PROTEIN AND AGE AT DEATH IN INHERITED PRION DISEASE. LANCET, 337(8752), 1286 - 1286.
    • Collinge J, Delisi LE, Boccio A, Johnstone EC, Lane A, Larkin C, Leach M, Lofthouse R, Owen F, Poulter M (1991). Evidence for a pseudo-autosomal locus for schizophrenia using the method of affected sibling pairs.. Br J Psychiatry, 158, 624 - 629.
    • Brown J, Smith S, Brun A, Collinge J, Gydesen S, Hardy J, Mullan M, Goate A (1991). Genetic characterization of a novel familial dementia.. Ann N Y Acad Sci, 640, 181 - 183.
    • RIDLEY RM, BAKER HF, POULTER M, LOFTHOUSE R, OWEN F, COLLINGE J, CROW TJ (1991). GENETICS OF HUMAN TRANSMISSIBLE DEMENTIA.
    • COLLINGE J (1991). PRION DISEASE - REDEFINING THE PHENOTYPE.
    • Walsh C, Collinge J, Crow TJ (1991). Molecular and clinical genetics in relation to psychiatric disease.. In Granville-Grossman K (Ed.), Recent Advances in Clinical Psychiatry (pp. 119 - 137). : Churchill-Livingstone.
    • Collinge J (1991). Prion disease: redefining the phenotype. In Bradley R, Savey M, Marchant B (Ed.), Sub-acute spongiform encephalopathies (pp. 225 - 231). : Dordrecht: Kluwer.
    • Ridley RM, Baker HF, Poulter M, Lofthouse R, Collinge J, Crow TJ (1991). Genetics of human transmissible dementia. In Bradley R, Savey M, Marchant B (Ed.), Sub-acute spongiform encephalopathies (pp. 203 - 218). : Dordrecht: Kluwer.
    • Collinge J, Curtis D (1991). Decreased hippocampal expression of a glutamate receptor gene in schizophrenia.. Br J Psychiatry, 159, 857 - 859.

    1990

    • OWEN F, POULTER M, COLLINGE J, CROW TJ (1990). A CODON 129 POLYMORPHISM IN THE PRIP GENE. NUCLEIC ACIDS RES, 18(10), 3103 - 3103.
    • COLLINGE J, OWEN F, POULTER M, HARDING AE, ROSSOR M, MULLEN M, LEACH M, CROW TJ (1990). PRION PROTEIN GENE ANALYSIS IN PRESENILE DEMENTING AND ATAXIC ILLNESSES. NEUROBIOL AGING, 11(3), 321 - 321.
    • Owen F, Poulter M, Collinge J, Crow TJ (1990). Codon 129 changes in the prion protein gene in Caucasians.. Am J Hum Genet, 46(6), 1215 - 1216.
    • Owen F, Poulter M, Shah T, Collinge J, Lofthouse R, Baker H, Ridley R, McVey J, Crow TJ (1990). An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease.. Brain Res Mol Brain Res, 7(3), 273 - 276.
    • Collinge J, Owen F, Poulter M, Leach M, Crow TJ, Rossor MN, Hardy J, Mullan MJ, Janota I, Lantos PL (1990). Prion dementia without characteristic pathology.. Lancet, 336(8706), 7 - 9.
    • ROBERTS GW, COLLINGE J (1990). BOVINE SPONGIFORM ENCEPHALOPATHY. BRIT MED J, 300(6729), 943 - 943.

    1989

    • Collinge J, Harding AE, Owen F, Poulter M, Lofthouse R, Boughey AM, Shah T, Crow TJ (1989). Diagnosis of Gerstmann-Sträussler syndrome in familial dementia with prion protein gene analysis.. Lancet, 2(8653), 15 - 17.
    • COLLINGE J, BOCCIO A, DELISI L, JOHNSTONE E, LOFTHOUSE R, OWEN F, POULTER M, RISBY D, SHAH T, TJ C (1989). Evidence for a pseudoautosomal locus for schizophrenia. Cytogenet Cell Genet, 51(1-4), 978 - 978.
    • Owen F, Poulter M, Lofthouse R, Collinge J, Crow TJ, Risby D, Baker HF, Ridley RM, Hsiao K, Prusiner SB (1989). Insertion in prion protein gene in familial Creutzfeldt-Jakob disease.. Lancet, 1(8628), 51 - 52.

    1987

    • Collinge J, Roberts CJ (1987). Study of the action of cicletanine in hyperuricemic patients.. J Clin Pharmacol, 27(10), 802 - 806.

    1983

    • Collinge J, Pycock CJ, Taberner PV (1983). Studies on the interaction between cerebral 5-hydroxytryptamine and gamma-aminobutyric acid in the mode of action of diazepam in the rat.. Br J Pharmacol, 79(3), 637 - 643.

    1982

    • Collinge J, Pycock C (1982). Differential actions of diazepam on the release of [3H]5-hydroxytryptamine from cortical and midbrain raphe slices in the rat.. Eur J Pharmacol, 85(1), 9 - 14.

    • Rossi M, Mead S, Collinge J, Rudge P, Vincent A (). Neuronal antibodies in patients with suspected or confirmed sporadic Creutzfeldt-Jakob Disease. Journal of Neurology, Neurosurgery, and Psychiatry, , - .