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Prof Hugh Gurling
Personal Profile
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Profile
Research Description
Research in the Molecular Psychiatry lab has used genetics as a method to understand the abnormal neurobiology causing schizophrenia, affective disorders and alcoholism.
The lab. has completed genome wide linkage scans on family samples of schizophrenia, bipolar disorder and Tourette syndrome in order to localise susceptibility genes to specific regions of chromosomes.
Genetic association studies with large case control samples were then used to fine map specific genes at the chromosomal linkage hot spots. The lab. showed that the CLINT1 (EPSIN 4), FXYD6, PCM1 and UHMK1(KIST) genes were implicated in genetic susceptibility to schizophrenia.
The P2RX7 TRPM2 and another unknown gene on chromosome 12 were implicated in genetic susceptibility to bipolar disorder. Next, genome wide association scans with 500K or 1 million SNP arrays have been completed on schizophrenia and bipolar case control samples and are planned for the alcoholism case control sample, including sub samples of Wernicke Korsakov's syndrome and alcoholic cirrhosis of the liver. Some of the genes involved in affective disorders are also involved in susceptibility to alcoholism.
Families of glutamate receptor genes as well as calcium channel genes have now been implicated in schizophrenia as well as bipolar disorder.
A second major effort in the lab. concerns the use of systems biology and pharmacogenomics to point the way to new drug and preventive strategies for the psychoses. Initially gene expression studies of antipsychotic drugs were carried out to identify glutamatergic receptor changes. Later, microarray studies of lithium, clozapine and haloperidol were carried out. This was followed by pathways analysis.
More recently genetic association data on bipolar disorders and schizophrenia has been converged with gene expression data on lithium, clozapine and haloperidol. The laboratory has established large case control samples in which known aetiological base pair changes have been implicated and it has been possible to correlate clinical changes at the level of brain morphology with genetic effects from the PCM1 gene on chromosome 8.
The lab. has also been collaborating with research groups at UCL and Imperial College who have established convincing animal models for ADHD and alcoholism. This has led to the finding of two human genes which are increasing susceptibility to alcoholism and ADHD.
Research Activities
Genetics and Neurobiology of Mental Illness
molecular neurobiology
Education Description
Teaching on genetics and neurobiology of psychiatry on MRCPsych, MSc, BSc taught courses. The Molecular Psychiatry Laboratory hosts PhD degrees in molecular genetics and neurobiology.
UCL Collaborators
Prof Anthony Dickenson; Dr Clare Stanford; Prof Marsha Morgan; Dr Andrew Mcquillin; Prof Steve Hunt
External Collaborators
Publications
- Ruderfer DM, Chambert K, Moran J, Talkowski M, Chen ES, Gigek C, Gusella JF, Blackwood DH, Corvin A, Gurling HM, Hultman CM, Kirov G, Magnusson P, O'Donovan MC, Owen MJ, Pato C, St Clair D, Sullivan PF, Purcell SM, Sklar P, Ernst C (2013). Mosaic copy number variation in schizophrenia.. Eur J Hum Genet, , - . doi:10.1038/ejhg.2012.287
- Kandaswamy R, McQuillin A, Sharp SI, Fiorentino A, Anjorin A, Blizard RA, Curtis D, Gurling HM (2013). Genetic Association, Mutation Screening, and Functional Analysis of a Kozak Sequence Variant in the Metabotropic Glutamate Receptor 3 Gene in Bipolar Disorder.. JAMA Psychiatry, , 1 - 8. doi:10.1001/jamapsychiatry.2013.38
- Szyszka P, Sharp SI, Dedman A, Gurling HM, McQuillin A (2012). A nonconservative amino acid change in the UPF3B gene in a patient with schizophrenia.. Psychiatr Genet, 22(3), 150 - 151. doi:10.1097/YPG.0b013e32834accbe
- Rizig MA, McQuillin A, Ng A, Robinson M, Harrison A, Zvelebil M, Hunt SP, Gurling HM (2012). A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia.. J Psychopharmacol, 26(9), 1218 - 1230. doi:10.1177/0269881112450780
- Pereira AC, McQuillin A, Puri V, Anjorin A, Bass N, Kandaswamy R, Lawrence J, Curtis D, Sklar P, Purcell SM, Gurling HM (2011). Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder.. Am J Med Genet B Neuropsychiatr Genet, 156(2), 177 - 187. doi:10.1002/ajmg.b.31153
- Lydall GJ, Bass NJ, McQuillin A, Lawrence J, Anjorin A, Kandaswamy R, Pereira A, Guerrini I, Curtis D, Vine AE, Sklar P, Purcell SM, Gurling HM (2011). Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder.. Psychiatr Genet, 21(6), 294 - 306. doi:10.1097/YPG.0b013e32834915c2
- Curtis D, Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Lawrence J, Anjorin A, Choudhury K, Datta SR, Puri V, Krasucki R, Pimm J, Thirumalai S, Quested D, Gurling HM (2011). Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.. Psychiatr Genet, 21(1), 1 - 4. doi:10.1097/YPG.0b013e3283413382
- Chen X, Lee G, Maher BS, Fanous AH, Chen J, Zhao Z, Guo A, van den Oord E, Sullivan PF, Shi J, Levinson DF, Gejman PV, Sanders A, Duan J, Owen MJ, Craddock NJ, O'Donovan MC, Blackman J, Lewis D, Kirov GK, Qin W, Schwab S, Wildenauer D, Chowdari K, Nimgaonkar V, Straub RE, Weinberger DR, O'Neill FA, Walsh D, Bronstein M, Darvasi A, Lencz T, Malhotra AK, Rujescu D, Giegling I, Werge T, Hansen T, Ingason A, Nöethen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Cantor RM, Ophoff R, Corvin A, Morris DW, Gill M, Pato CN, Pato MT, Macedo A, Gurling HM, McQuillin A, Pimm J, Hultman C, Lichtenstein P, Sklar P, Purcell SM, Scolnick E, St Clair D, Blackwood DH, Kendler KS, GROUP investigators , International Schizophrenia Consortium (2011). GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.. Mol Psychiatry, 16(11), 1117 - 1129. doi:10.1038/mp.2010.96
- Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF, Wellcome Trust Case-Control Consortium (2011). Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.. Mol Psychiatry, 16(1), 2 - 4. doi:10.1038/mp.2009.107
- Lydall GJ, Saini J, Ruparelia K, Montagnese S, McQuillin A, Guerrini I, Rao H, Reynolds G, Ball D, Smith I, Thomson AD, Morgan MY, Gurling HM (2011). Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence.. Neurosci Lett, 500(3), 162 - 166. doi:10.1016/j.neulet.2011.05.240
- Kasiakogia-Worlley K, McQuillin A, Lydall GJ, Patel S, Kottalgi G, Gunwardena P, Cherian R, Rao H, Hillman A, Gobikrishnan N, Douglas E, Qureshi SY, Jauhar S, Ball D, Okane A, Owens L, Dedman A, Sharp SI, Kandaswamy R, Guerrini I, Thomson AD, Smith I, Dar K, Morgan MY, Gurling HM (2011). Lack of allelic association between markers at the DRD2 and ANKK1 gene loci with the alcohol-dependence syndrome and criminal activity.. Psychiatr Genet, 21(6), 323 - 324. doi:10.1097/YPG.0b013e3283458a68
- Datta SR, McQuillin A, Rizig M, Blaveri E, Thirumalai S K, G L, J B, N J P, V C, K P, J C, C F, G W, N C, D Z, M P, A K, R SC, D G, D HM (2010). A threonine to isoleucine mis-sense mutation in the pericentriolar material 1 (PCM1) gene is strongly associated with schizophrenia.. Molecular Psychiatry, , - .
- Ganeshan B, Miles KA, Young RC, Chatwin CR, Gurling HM, Critchley HD (2010). Three-dimensional textural analysis of brain images reveals distributed grey-matter abnormalities in schizophrenia.. Eur Radiol, 20(4), 941 - 948. doi:10.1007/s00330-009-1605-1
- Perlis RH, Smoller JW, Ferreira MA, McQuillin A, Bass N, Lawrence J, Sachs GS, Nimgaonkar V, Scolnick EM, Gurling H, Sklar P, Purcell S (2009). A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.. American Journal of Psychiatry, 166(6), 718 - 725.
- Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Robinson M, Lawrence J, Anjorin A, Sklar P, Gurling HM, Curtis D (2009). No evidence for excess runs of homozygosity in bipolar disorder.. Psychiatric Genetics, 19(4), 165 - 170.
- Bass NJ, Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, Lawrence J, Quested D, Pimm J, Curtis D, Gurling HM (2009). Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia.. Behavioral and Brain Functions, 5, 28 - .
- Ng MYM, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T, Riley B, Paunio T, Pulver AE, Irmansyah H, P A E, M W, D B W, N M L, C M, B J B, L M, M S, P G, D L A, G L, B F, M D G, H M D G, P V L, E M, H B, W W, E M F, P T, M T H, H-G O, Y K, K S W, B F, A W, D O, A P, L N, G L, V K L, K Y P, G D, D S, S G O, M J OD, M C N, N H, E nRaventos H, Nicolini H, Albus M, Maier W, Nimgaonkar VL, Terenius L, Mallet J, Jay M, Godard S, Nertney D, Alexander M, Crowe RR, Silverman JM, Basset AS, Roy M-A, Mérette C, Pato CN, Pato MT, LouwRoos J, Kohn Y, Amann-Zalcenstein D, Kalsi G, McQuillin A, Curtis D, Brynjolfson J, Sigmundsson T, Petursson H, Sanders AR, Duan J, Jazin E, Myles-Worsley M, KarayiorgouM LM (2009). Meta-analysis of 32 genomewide linkage studies of schizophrenia. Molecular Psychiatry, 14(8), 774 - 785.
- Sharp SI, McQuillin A, Gurling HM (2009). Genetics of attention-deficit hyperactivity disorder (ADHD).. Neuropharmacology, 57, 590 - 600.
- Sklar P, Ferreira MAR, Craddock N, Meng Y, Ruderfer D, Fran J, Daly MJ, Holmans P, O'Donovan M, Scolnick EM, Corvin AP, Blackwood DH, Gurling HM, Purcell SM (2009). Collaborative Genome-Wide Analysis Supports a Role for ANK3 and CACNA1C in Bipolar Disorder.
- Guerrini I, Thomson AD, Gurling HM (2009). Molecular genetics of alcohol-related brain damage.. Alcohol Alcohol, 44(2), 166 - 170. doi:10.1093/alcalc/agn101
- Ferreira MOD, M Meng YAJI, A Ruderfer1 DMJ, L Fan J Kirov GPRG, E Smoller JWG, D Stone JN, I Chambert KH, M L Nimgaonkar VM, V Thase MEC, S Sachs GSF, J Gordon-Smith KA, K G Gabriel SBF, C Blumenstiel BD, M Breen GG, M Morris DWE, A Muir WJM, K Williamson RM, D J McLean ASC, D VanBeck MP, A Kandaswamy RM, A Collier DAB, N J Young AHL, J Ferrier JNA, A Farmer AC, D Scolnick EM, P Daly MJC, A P Holmans PAB, D H Gurling HMO, M J Purcell SHS, P Craddock N (2008). Collaborative genome-wide association analysis of 10,596 individuals supports a role for Ankyrin-G (ANK3) and the alpha-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) in bipolar disorder. Nature Genetics, 40(9), 1056 - 1058.
- Knapp S, Hosie AM, Anstee QM, Thomos P, Mortensen M, Martinez A, Tymowska-Lalanne Z, McQuillin A, Gurling HM, Morgan MY, Kuo YT, Herlihy A, Bell JD, Robinson I, Fisher E, Brown S, Stephens D, Smart TG, Thomas HC (2008). IDENTIFICATION OF A MODEL OF ALCOHOL PREFERENCE AND ITS SIMILARITY TO HUMAN ALCOHOLISM.
- Sklar P, Smoller J, Fan J, Ferreira M, Perlis R, Chambert K, Nimgaonkar V, McQueen MB, Faraone SV, Kirby A, deBakker PIK, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie K, Franklin J, Muir WJ, McGhee KA, MacIntyre DA, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM (2008). Whole-genome association study of bipolar disorder. Molecular Psychiatry, 13(6), 558 - 569. doi:10.1038/sj.mp.4002151
- Puri V, McQuillin A, Choudhury K, Datta S, Pimm J, Thirumalai S, Krasucki R, Lawrence J, Quested D, Bass NJ, Moorey H, Fountoulaki G, Kar Ray M, Sule A, Curtis D, Gurling HMD (2008). Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia. European Journal of Human Genetics, , - .
- McQuillin A, Bass NJ, Choudhury K, Puri V, Kosmin M, Lawrence J, Curtis D, Gurling HMD (2008). Replication and combined genetic analyses show that a non conservative amino acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar and unipolar affective disorders. Molecular Psychiatry, , - .
- Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary IJ, Harris E, Isometsä ET, Lawrence , Lönnqvist J, Muir M, Palotie A, Partonen T, Paunio T, Pylkkö E, Robinson M, Soronen P, Suominen K, Suvisaari J, Thirumalai S, StClair D, Gurling H, Peltonen L, P D DA (2008). Heterogeneity and Interplay in Schizophrenia and Bipolar Disorder. Molecular Psychiatry, , - .
- Stone JL, O'Donovan MC, Gurling H, Kirov GK, Blackwood DH, Corvin A, Craddock NJ, Gill M, Hultman CM, Lichtenstein P, McQuillin A, Pato CN, Ruderfer DM, Owen MJ, St Clair D, Sullivan PF, Sklar P, Ruderfer DM, Korn J, Kirov GK, Macgregor S, McQuillin A, Morris DW, O'Dushlaine CT, Daly MJ, Visscher PM, Holmans PA, Hultman CM, Kirov GK, Lichtenstein P, Pato CN, Scolnick EM, St Clair D, Nikolov I, Norton N, Williams H, Toncheva D, Milanova V, Choudhury K, Datta S, Pimm J, Thirumalai S, Puri V, Krasucki R, Lawrence J, Quested D, Bass N, Curtis D, Crombie C, Fraser G, Leh Kwan S, Walker N, Muir WJ, McGhee KA, Pickard B, Malloy P, Maclean AW, Van Beck M, Visscher PM, Macgregor S, Pato MT, Medeiros H, Middleton F, Carvalho C, Morley C, Fanous A, Conti D, Knowles JA, Paz Ferreira C, Macedo A, Helena Azevedo M, Pato CN, Ruderfer DM, Korn J, McCarroll SA (2008). Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature, 445, 237 - 241.
- Puri V, McQuillin A, Choudhury K, Datta S, Pimm J, Thirumalai S, Krasucki R, Lawrence J, Quested D, Bass N, Moorey H, Morgan J, Punukollu B, Kandasami G, Curtis D, Gurling H (2007). Fine mapping by genetic association implicates the chromosome 1q23.3 Gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene. Biological Psychiatry, 61(7), 873 - 879. doi:10.1016/j.biopsych.2006.06.014
- McQuillin A, Rizig AM, Gurling H (2007). A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder. Pharmacogenetics and Genomics, 17(8), 605 - 617.
- Gurling H, Pimm J, McQuillin A (2007). Replication of genetic association studies between markers at the Epsin 4 gene locus and schizophrenia in two Han Chinese samples. Schizophrenia Research, 89(1-3), 357 - 359.
- Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, Lawrence J, Pimm J, Bass N, Lamb G, Moorey H, Morgan J, Punukollu B, Kandasami G, Kirwin S, Sule A, Quested D, Curtis D, Gurling HM (2007). Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia.. Behavioral and Brain Functions, 3(50), - .
- Petek E, Schwarzbraun T, Noor N, Patel M, Nakabayashi K, Choufani S, Windpassinger C, Stamenkovic M, Robertson MM, Aschauer HN, Gurling HM, Kroisel PM, Wagner K, Scherer SW, Vincent JB (2007). Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome. Molecular Genetics and Genomics, 277(1), 71 - 81.
- Choudhury K, McQuillin A, Thirumalai S, Lawrence J, Krasucki R, Puri V, Datta S, Quested D, Bass N, Pimm J, Kandasami G, Morgan J, Punukollu B, Nadeem H, Curtis D, Gurling H (2007). A genetic association study implicates the chromosome 11q23.3 gene FXYD6 encoding phopshohippolin in susceptibility to schizophrenia in University College London and Aberdeen case control samples. The American Journal of Human Genetics, 80(4), 664 - 672.
- Choudhury K, McQuillin A, Puri V, Pimm J, Datta S, Thirumalai S, Krasucki R, Lawrence J, Bass NJ, Quested D, Crombie C, Fraser G, Walker N, Nadeem H, Johnson S, Curtis D, St Clair D, Gurling HM (2007). A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia.. Am J Hum Genet, 80(4), 664 - 672. doi:10.1086/513475
- Petek E, Schwarzbaum T, Noor A, Patel M, Nakabayashi K, Choufani S, Windpassinger C, Stamenkovic M, Robertson MM, Aschauer HN, Gurling HM (2006). Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome. Molecular and Genetic Genomics, 277(1), 71 - 81.
- McQuillin A, Bass NJ, Kalsi G, Lawrence J, Puri V, Choudhury K, Detera-Wadleigh SD, Curtis D, Gurling HMD (2006). Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. Molecular Psychiatry, 11(2), 134 - 142. doi:10.1038/sj.mp.4001759
- Puri V, McQuillin A, Thirumalai S, Lawrence J, Krasucki R, Choudhury K, Datta S, Kerwin S, Quested D, Bass N, Pimm J, Lamb G, Moorey H, Kandasami G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Nadeem H, Curtis D, Gurling HM (2006). Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British Sample.. Biological Psychiatry, 59(2), 195 - 197. doi:10.1016/j.biopsych.2005.08.015
- Rizig MA, McQuillin A, Puri V, Choudhury K, Datta S, Thirumalai S, Lawrence J, Quested D, Pimm J, Bass N, Lamb G, Moorey H, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Kandasami G, Curtis D, Gurling H (2006). Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141(3), 296 - 300. doi:10.1002/ajmg.b.30288
- Gurling HM, Critchley H, Datta SR, McQuillin A, Blaveri E, Thirumalai S, Pimm J, Krasucki R, Kalsi G, Quested D, Lawrence J, Bass N, Choudhury K, Puri V, O'Daly O, Curtis D, Blackwood D, Muir W, Malhotra AK, Buchanan RW, Good CD, Frackowiak RS, Dolan RJ (2006). Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Archives of General Psychiatry, 63(8), 844 - 854. doi:10.1001/archpsyc.63.8.844
- Kalsi G, McQuillin A, Degn B, Lundorf MD, Bass NJ, Lawrence J, Choudhury K, Puri V, Nyegaard M, Curtis D, Mors O, Kruse T, Kerwin S, Gurling HMD (2006). Identification of the Slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24. American Journal of Psychiatry, 163(10), 1767 - 1776. doi:10.1176/appi.ajp.163.10.1767
- Pereira ACP, McQuillin A, Mors O, Olsen IM, Puri V, Choudhury K, Bass NJ, Gurling HM (2006). Detection and characterisation of the bipolar susceptibility gene Slynar in the mouse.
- Etain B, Mathieu F, Rietschel M, Maier W, Albus M, McKeon P, Roche S, Kealey C, Blackwood D, Muir W, Bellivier F, Henry C, Dina C, Gallina S, Gurling H, Malafosse A, Preisig M, Ferrero F, Cichon S, Schumacher J, Ohlraun S, Borrmann-Hassenbach M, Propping P, Abou Jamra R, Schulze TG, Marusic A, Dernovsek ZM, Giros B, Bourgeron T, Lemainque A, Bacq DB, C C, C N, M M L, M Leboyer M (2006). Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. Molecular Psychiatry, 7, 1359 - 4184. doi:10.1038/sj.mp.4001815
- Datta SR, McQuillin A, Rizig MA, Puri V, Choudhury KH, Thirumalai S, Lawrence J, Bass N, Curtis D, Gurling HM (2005). Detection of potential aetiological base pair changes causing genetic susceptibility to schizophrenia in the pericentriolar material 1 (PCM1) gene on chromosome 8p22 supports evidence from allelic association.
- McQuillin A, Kalsi G, Degn B, Lundorf MD, Bass NJ, Lawrence J, Choudhury K, Puri VH, Nyegaard M, Curtis D, Mors O, Kruse T, Gurling HM (2005). Allelic and haplotypic association with bipolar disorder implicates a 300 kilobase region on chromosome 12q24.3 containing novel brain expressed gene sequences.
- Guerrini I, Thomson AD, Cook CC, McQuillin A, Sharma V, Kopelman M, Reynolds G, Jauhar P, Harper C, Gurling HM (2005). Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 137B(1), 17 - 19. doi:10.1002/ajmg.b.30194
- Guerrini I, Cook CCH, Kest W, Devitgh A, McQuillin A, Curtis D, Gurling HMD (2005). Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2. BMC Genetics, 6(art.11), - . doi:10.1186/1471-2156-6-11
- Bass N, McQuillin A, Lawrence J, Choudhury , Puri V, Kalsi G, Curtis D, Gurling HM (2005). Evidence of allelic association of bipolar disorder with two genes P2RX7 and AY070435 6 MB apart on 12q24.
- Choudhury KH, Rizig MA, McQuillin A, Puri V, Datta SR, Thirumalai S, Lawrence J, Bass N, Curtis D, Gurling HM (2005). Genetic association and gene expression studies implicate the chromosome 11q23.3 gene FXYD2 in susceptibility to schizophrenia.
- Vincent JB, Melmer G, Bolton PF, Hodgkinson S, Holmes D, Curtis D, Gurling HM (2005). Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region.. Psychiatr Genet, 15(2), 83 - 90.
- Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H, Datta SR, Kalsi G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Curtis D, Gurling H (2005). The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia.. The American Journal of Human Genetics, 76(5), 902 - 907.
- Curtis D, Brett P, Dearlove AM, McQuillin A, Kalsi G, Robertson MM, Gurling HMD (2004). Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13. Psychiatric Genetics, 14(2), 83 - 87.
- Buttenschon HN, Mors O, Ewald H, McQuillin A, Kalsi G, Lawrence J, Gurling H, Kruse TA (2004). No Association between a neuronal nitric oxide synthase (NOSI) gene polymorphism on chromosome 12q24 and bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, (124B), 73 - 75.
- Vincent JB, Kolozsvari D, Roberts WS, Bolton PF, Gurling HMD, Scherer SW (2004). Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 129B(1), 82 - 84. doi:10.1002/ajmg.b.30069
- Rizig MA, McQuillin A, Datta SR, Pimm J, Thirumalai S, Moorey H, Quested DD, Kalsi G, Bass N, Lawrence J, Curtis D, Hubank M, Hunt SP, Gurling HMD (2004). A microarray gene expression and genetic association study of the RGS4 gene in schizophrenia.
- Rizig MA, McQuillin A, Hubank M, Hunt SP, Gurling HMD (2004). A microarray gene expression study of the side effects of the antipsychotic drugs clozapine and haloperidol: Antipsychotic metabolic signatures in the right side of the mouse brain as model for the treatment of schizophrenia.
- Carbonell J, Allen R, Kalsi G, McQuillin A, Livingston G, Katona C, Walker Z, Rands G, Stevens T, Crossan I, Curtis D, Gurling H (2003). Variations in the DCP1 gene, encoding the angiotensin converting enzyme ACE, is not associated with increased susceptibility to Alzheimer's disease. Psychiatric Genetics, 13, 47 - 50.
- Curtis D, Kalsi G, Brynjolfsson J, McInnis M, O'Neill J, Smyth C, Moloney E, Murphy P, McQuillin A, Petursson H, Gurling H (2003). Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q.. Psychiatric Genetics, 13(2), 77 - 84.
- Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo SH, Berrettini WH, Yoshikawa T, Peltonen L, Lonnqvist J, Nothen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin JL, Antonarakis SE, Akarsu N (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.. The American Journal of Human Genetics, 73(1), 49 - 62.
- Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lonnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoega T, Helgason T (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.. The American Journal of Human Genetics, 73(1), 34 - 48.
- (2002). A quick and simple method for detecting subjects with abnormal genetic background in case-control samples. Annals of Human Genetics, 66, 235 - 244.
- Jorgensen TH, Degn B, Wang AG, Vang M, Gurling H, Kalsi G, McQuillin A, Kruse TA, Mors O, Ewald H (2002). Linkage disequilibrium and demographic history of the isolated population of the Faroe Islands. European Journal of Human Genetics, 10, 381 - 387.
- McQuillin A, Kalsi G, Moorey H, Lamb G, Mayet S, Quested D, Baker P, Curtis D, Gurling HM (2002). A novel polymorphism in exon 11 of the WKL1 gene shows no association with schizophrenia. European Journal of Human Genetics, 10, 491 - 494.
- (2001). Enhanced cationic liposome-mediated transfection using the DNA-binding peptide mu (mu) from the adenovirus core. Gene Therapy, 8, 453 - 460.
- Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D (2001). Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.. The American Journal of Human Genetics, 68(3), 661 - 673.
- Blaveri E, Kalsi G, Lawrence J, Quested D, Moorey H, Lamb G, Kohen D, Shiwach R, Chowdhury U, Curtis D, McQuillin A, Gramoustianou ES, Gurling HM (2001). Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1). European Journal of Human Genetics, 9, 469 - 472.
- (2001). Mild learning difficulties and offending behaviour - is there a link with monoamine oxidase A deficiency?. Psychiatric Genetics, 11, 173 - 176.
- (2001). Gene expression in schizophrenia. American Journal of Psychiatry, 158, 1740 - 1741.
- Murray KD, Etheridge CJ, Shah SI, Matthews DA, Russell W, Gurling HM, Miller AD (2001). Enhanced cationic liposome-mediated transfection using the DNA-binding peptide mu (mu) from the adenovirus core.. Gene Ther, 8(6), 453 - 460. doi:10.1038/sj.gt.3301401
- Vincent JB, Neves-Pereira ML, Paterson AD, Yamamoto E, Parikh SV, Macciardi F, Gurling HM, Potkin SG, Pato CN, Macedo A, Kovacs M, Davies M, Lieberman JA, Meltzer HY, Petronis A, Kennedy JL (2000). An unstable trinucleotide-repeat region on chromosome 13 implicated in spinocerebellar ataxia: a common expansion locus.. Am J Hum Genet, 66(3), 819 - 829. doi:10.1086/302803
- Vincent JB, Herbrick JA, Gurling HM, Bolton PF, Roberts W, Scherer SW (2000). Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual.. Am J Hum Genet, 67(2), 510 - 514. doi:10.1086/303005
- McQuillin A, Lawrence J, Kalsi G, Chen A, Gurling H, Curtis D (1999). No allelic association between bipolar affective disorder and the tryptophan hydroxylase gene. Archives of General Psychiatry, 56(1), 99 - 101.
- McQuillin A, Lawrence J, Curtis D, Kalsi G, Smyth C, Hannesdottir S, Gurling H (1999). Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder. Psychological Medicine, 29(6), 1449 - 1454.
- Chen AC, Gurling HM (1999). D2 dopamine receptor but not AMPA and kainate glutamate receptor genes show altered expression in response to long term treatment with trans- and cis-flupenthixol in the rat brain.. Brain Res Mol Brain Res, 68(1-2), 14 - 21.
- Kalsi G, Gamble D, Curtis D, Brynjolfsson J, Sigmundsson T, Butler R, Read T, Murphy P, Petursson H, Gurling HM (1999). No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11.. Psychiatr Genet, 9(4), 197 - 199.
- Vincent JB, Masellis M, Lawrence J, Choi V, Gurling HM, Parikh SV, Kennedy JL (1999). Genetic association analysis of serotonin system genes in bipolar affective disorder.. Am J Psychiatry, 156(1), 136 - 138.
- Murray KD, McQuillin A, Stewart L, Etheridge CJ, Cooper RG, Miller AD, Gurling HM (1999). Cationic liposome-mediated DNA transfection in organotypic explant cultures of the ventral mesencephalon.. Gene Therapy, 6(2), 190 - 197.
- (1998). A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: further support for a susceptibility locus for schizophrenia at 22q12. Schizophrenia Research, 32, 115 - 121.
- (1998). No evidence of expansion of CAG or GAA repeats in schizophrenia families and monozygotic twins. Human Genetics, 103, 41 - 47.
- (1998). Point mutation in intron 10 of FMR1 is unlikely to be a cause of fragile X syndrome. Human Mutation, 12, 431 - 432.
- (1998). Report of the Chromosome 21 workshop, 5th International Congress of Psychiatric Genetics. Psychiatric Genetics, 8, 109 - 114.
- (1998). Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. Genomics, 47, 423 - 425.
- (1998). Brain changes in schizophrenia. Volumetric MRI study of families multiply affected with schizophrenia - The Maudsley Family Study 5. The British Journal of Psychiatry, 173, 132 - 138.
- (1998). Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long term treatment with cis and trans flupenthixol as a model for understanding the mode of action of schizophrenia drug treatme. Molecular Brain Research, 54, 92 - 100.
- Kalsi G, Curtis D, Brynjolfsson J, Sigmundsson T, Petursson H, Butler R, Read T, Murphy P, Gurling HM (1998). Tests of linkage, allelic and genotypic association between schizophrenia and the gene for the D3 dopamine receptor, DRD3.. Psychiatr Genet, 8(3), 187 - 189.
- (1998). Description of the genetic analysis workshop: 10 bipolar disorder linkage data sets. Genetic Epidemiology, 14, 563 - 568.
- Eapen V, O'Neill J, Gurling HMD, Robertson MM (1997). Sex of parent transmission effect in Tourette's syndrome: evidence for earlier age at onset in maternally transmitted cases suggests a genomic imprinting effect. Neurology, 48(4), 934 - 937.
- Gurling HMD, Vincent J, Melmer G, Bolton P, Hodgkinson S, Holmes D, Lord C, Rutter M (1997). Investigation of abnormal methylation and the CGG repeat expansion of the FMR-1 gene in familial autism and in cases autism with low level fragile X expression. Human Heredity, 222, 254 - 262.
- Smyth C, Kalsi G, Curtis D, Brynjolfsson J, O'Neill J, Rifkin L, Moloney E, Murphy P, Petursson H, Gurling HMD (1997). Two locus admixture linkage analysis of bipolar and unipolar disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22. Genomics, 39, 1 - 8.
- Smyth C, Kalsi G, Brynjolfsson J, Sherrington RS, O'Neill J, Curtis D, Rifkin L, Murphy P, Petursson H, Gurling HMD (1997). Linkage analysis of manic depression (bipolar affective disorder) in Icelandic and British kindreds using markers on the short arm of chromosome 18. Human Heredity, (222), 268 - 278.
- McQuillin A, Murray KD, Etheridge CJ, Stewart L, Cooper RG, Brett PM, Miller AD, Gurling HMD (1997). Optimisation of liposome mediated transfection of a neuronal cell line. NeuroReport, 8(6), 1481 - 1484.
- Kalsi G, Smyth C, Brynjolfsson J, O'Neill J, Curtis D, Rifkin L, Moloney E, Petursson H, Gurling HMD (1997). A test of Xq27-28 linkage in bipolar and unipolar (manic depressive) families selected for absent male to male transmission. The British Journal of Psychiatry, 171, 578 - 581.
- Sharma T, du B, Lewis S, Sigmundsson T, Gurling H, Murray R (1997). The Maudsley family study .1. Structural brain changes on magnetic resonance imaging in familial schizophrenia. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 21, 1297 - 1315.
- Brett PM, Curtis D, Robertson MM, Gurling HMD (1997). Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome. Biological Psychiatry, 42(10), 941 - 947.
- Turner A, Lawrence J, Chen A, Cook CCH, Gurling HMD (1997). Frequency of the A1/A2 alleles of the D2 dopamine receptor (DRD2) gene in a screened British, Caucasian control group. Addiction Biology, 2, 207 - 213.
- Gurling HM, Bolton PF, Vincent J, Melmer G, Rutter M (1997). Molecular and cytogenetic investigations of the fragile X region including the Frax A and Frax E CGG trinucleotide repeat sequences in families multiplex for autism and related phenotypes.. Hum Hered, 47(5), 254 - 262.
- Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P, Barnard EA, Petursson H, Gurling HM (1997). Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5.. Am J Med Genet, 74(1), 50 - 52.
- Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P, Petursson H, Barnard EA, Gurling HM (1997). Exclusion of linkage of schizophrenia to the gene for the glutamate GluR5 receptor.. Biol Psychiatry, 41(2), 243 - 245.
- Kalsi G, Sherrington R, Mankoo BS, Brynjolfsson J, Sigmundsson T, Curtis D, Read T, Murphy P, Butler R, Petursson H, Gurling HM (1996). Linkage study of the D5 dopamine receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees.. Am J Psychiatry, 153(1), 107 - 109.
- Cook CH, Palsson G, Turner A, Holmes DS, Brett PM, Curtis D, Petursson H, Gurling HMD (1996). A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism. The British Journal of Psychiatry, 169(2), 243 - 248.
- Brett PM, Curtis D, Robertson MM, Dahlitz M, Gurling HMD (1996). Linkage analysis and exclusion of regions of chromosomes 3 and 8 in Gilles de la Tourette syndrome following the identification of a balanced reciprocal translocation 46 XY, t(3:8)(p21.3 q24.1) in a case of Tourette syndrome. Psychiatric Genetics, 6(3), 99 - 105.
- Vincent JB, Konecki DS, Munstermann E, Bolton P, Poustka A, Poustka F, Gurling HM (1996). Point mutation analysis of the FMR-1 gene in autism.. Mol Psychiatry, 1(3), 227 - 231.
- Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P, Petursson H, Barnard EA, Gurling HM (1996). Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia.. Am J Psychiatry, 153(12), 1634 - 1636.
- Brett PM, Curtis D, Robertson MM, Gurling HMD (1995). Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior. American Journal of Psychiatry, 152(3), 437 - 440.
- Kalsi G, Curtis D, Brynjolfsson J, Butler R, Sharma T, Murphy P, Read T, Petursson H, Gurling HM (1995). Investigation by linkage analysis of the XY pseudoautosomal region in the genetic susceptibility to schizophrenia.. Br J Psychiatry, 167(3), 390 - 393.
- Brett PM, Curtis D, Robertson MM, Gurling HMD (1995). The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase. Biological Psychiatry, 37(8), 533 - 540.
- Kalsi G, Mankoo BS, Curtis D, Brynjolfsson J, Read T, Sharma T, Murphy P, Petursson H, Gurling HM (1995). Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites.. Psychol Med, 25(3), 531 - 537.
- Cook CC, Gurling HM (1994). The D2 dopamine receptor gene and alcoholism: a genetic effect in the liability for alcoholism.. J R Soc Med, 87(7), 400 - 402.
- Brett PM, Le Bourdelles B, See CG, Whiting PJ, Attwood J, Woodward K, Robertson MM, Kalsi G, Povey S, Gurling HMD (1994). Genomic cloning and localization by FISH and linkage analysis of the human gene encoding the primary subunit NMDAR1 (GRIN1) of the NMDA receptor channel. Annals of Human Genetics, 58(2), 95 - 100.
- Kalsi G, Mankoo BS, Brynjolfsson J, Curtis D, Read T, Murphy P, Sharma T, Petursson H, Gurling HM (1994). The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia.. Psychiatr Genet, 4(4), 219 - 227.
- Curtis D, Kalsi G, Gurling HM (1994). Pseudoautosomal linkage in schizophrenia.. Br J Psychiatry, 165(1), 117 - 119.
- Curtis D, Sherrington R, Brett PM, Holmes DS, Kalsi G, Brynjolfsson J, Petursson H, Rifkin L, Murphy P, Moloney E, Melmer G, Gurling HMD (1993). Genetic linkage analysis of manic depression in Iceland. Journal of the Royal Society of Medicine, 86(9), 506 - 510.
- Cook CC, Gurling HM, Curtis D (1993). DOLINK--a computer program to facilitate management of genetic data and analyses.. Ann Hum Genet, 57(Pt 4), 307 - 310.
- Curtis D, Brynjolfsson J, Petursson H, Holmes S, Sherrington R, Brett PM, Rifkin L, Murphy P, Moloney E, Melmer G, Gurling HMD (1993). Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A). Annals of Human Genetics, 57(1), 27 - 39.
- Brett PM, Melmer G, Robertson MM, Gurling HMD (1993). A microsatellite polymorphism at the THRB locus.
- Brett PM, Robertson M, Gurling H, Curtis D (1993). Failure to find linkage and increased homozygosity for the dopamine D3 receptor gene in Tourette's syndrome.
- Curtis D, Robertson MM, Gurling HM (1992). Autosomal dominant gene transmission in a large kindred with Gilles de la Tourette syndrome.. Br J Psychiatry, 160, 845 - 849.
- Mankoo BS, Sherrington R, De La Concha A, Kalsi G, Curtis D, Melmer G, Gurling HM (1991). Two microsatellite polymorphisms at the D5S39 locus.. Nucleic Acids Res, 19(8), 1963 - .
- MELMER G, VINCENT J, GURLING HM (1991). ISOLATION OF EXONS BY PCR AMPLIFICATION WITH OLIGONUCLEOTIDES CORRESPONDING TO SPLICE SITE CONSENSUS SEQUENCES. CYTOGENET CELL GENET, 58(3-4), 2150 - 2151.
- VINCENT J, GURLING HM, MELMER G (1991). OLIGONUCLEOTIDES AS SHORT AS 8-MERS CAN BE USED FOR PCR AMPLIFICATION. CYTOGENET CELL GENET, 58(3-4), 2155 - 2155.
- VINCENT J, GURLING HM, MELMER G (1991). ISOLATION OF PUTATIVE HTF ISLANDS BY PCR. CYTOGENET CELL GENET, 58(3-4), 1904 - 1905.
- MELMER G, GURLING HM (1991). HYBRIDIZATION OF THE VNTR CORE OLIGONUCLEOTIDE GNNGTGGG TO 350 COSMIDS FROM CHROMOSOME-7. CYTOGENET CELL GENET, 58(3-4), 1923 - 1924.
- Gurling HM, Curtis D, Murray RM (1991). Psychological deficit from excessive alcohol consumption: evidence from a co-twin control study.. Br J Addict, 86(2), 151 - 155.
- Melmer G, Brynjolfsson J, Curtis D, Holmes D, Brett PM, Rifkin L, Murphy P, Sherrington R, Petursson H, Gurling H (1991). Report of current progress in linkage analysis of manic depression in Iceland and at University College and Middlesex School of Medicine.
- Melmer G, Sherrington R, Mankoo B, Kalsi G, Curtis D, Gurling HM (1991). A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76.. Genomics, 11(3), 767 - 769.
- Curtis D, Gurling HM (1991). Using a dummy quantitative variable to deal with multiple affection categories in genetic linkage analysis.. Ann Hum Genet, 55(Pt 4), 321 - 327.
- Brett PM, Melmer G, Gurling HMD (1991). A microsatellite polymorphism at the D3S11 locus.
- Holmes D, Brynjolfsson J, Brett PM, Curtis D, Petursson H, Sherrington R, Gurling H (1991). No evidence for a susceptibility locus predisposing to manic depression in the region of the dopamine (D2) receptor gene. The British Journal of Psychiatry, 158(5), 635 - 641.
- Mankoo BS, Melmer G, Kalsi G, Sherrington R, Gurling HM (1991). A TaqI polymorphism detected by a genomic clone at the locus D5S39 (5q11-13).. Nucleic Acids Res, 19(7), 1720 - .
- Brett PM, Curtis D, Melmer G, Sherrington R, Holmes D, Robertson M, Gurling H (1991). Linkage analysis in a large pedigree multiply affected with Gilles de la Tourette syndrome.
- De La Concha A, McKie J, Hodgkinson S, Mankoo BS, Gurling HM (1991). Stereospecific effect of flupenthixol on neuroreceptor gene expression.. Brain Res Mol Brain Res, 10(2), 123 - 127.
- Brett PM, Curtis D, Gourdie A, Schnieden V, Jackson G, Holmes D, Robertson M, Gurling H (1990). Possible linkage of Tourette syndrome to markers on short arm of chromosome 3 (C3p21-14).
- Gurling HM (1990). Recent advances in the genetics of psychiatric disorder. In (Ed.), Ciba Found Symp (pp. 48 - 57). : .
- Gurling H (1990). Genetic linkage and psychiatric disease. Nature, 344(6264), 298 - 298. doi:10.1038/344298a0
- Hodgkinson SM, M J Gurling HM (1990). The role of genetic factors in the etiology of the affective disorders. Behavior Genetics, 20(2), 235 - 250.
- Curtis D, Gurling H (1990). Unsound methodology in investigating a pseudoautosomal locus in schizophrenia. The British Journal of Psychiatry, 156, 415 - 416.
- Gurling HM, Sherrington RP, Brynjolfsson J, Read T, Curtis D, Mankoo BJ, Potter M, Petursson H (1989). Recent and future molecular genetic research into schizophrenia.. Schizophr Bull, 15(3), 373 - 382.
- Brett PM, Robertson M, Sherrington RP, Holmes D, Dahlitz M, Gurling HMD (1989). Linkage analysis of Gilles de la Tourette syndrome (GTS) in a large British pedigree.
- Gurling HM (1988). Testing the retrovirus hypothesis of manic depression and schizophrenia with molecular genetic techniques.. J R Soc Med, 81(6), 332 - 334.
- Gurling HM, Sherrington RP, Brynjolfsson J, Potter M, McInnis M, Petursson H, Hodgkinson S (1988). Molecular genetics and heterogeneity in manic depression.. Mol Neurobiol, 2(2), 125 - 132.
- Hodgkinson S, Gurling HM, Marchbanks RH, McInnis M, Petursson H (1987). Minisatellite mapping in manic depression.. J Psychiatr Res, 21(4), 589 - 596.
- Gurling HM, Murray RM (1987). Genetic influence, brain morphology, and cognitive deficits in alcoholic twins.. Prog Clin Biol Res, 241, 71 - 82.
- Mullan MJ, Gurling HM, Oppenheim BE, Murray RM (1986). The relationship between alcoholism and neurosis: evidence from a twin study.. Br J Psychiatry, 148, 435 - 441.
- Gurling HM, Murray RM, Ron MA (1986). Increased brain radiodensity in alcoholism. A co-twin control study.. Arch Gen Psychiatry, 43(8), 764 - 767.
- Feder J, Gurling HM, Darby J, Cavalli-Sforza LL (1985). DNA restriction fragment analysis of the proopiomelanocortin gene in schizophrenia and bipolar disorders.. Am J Hum Genet, 37(2), 286 - 294.
- Gurling HM, Grant S, Dangl J (1985). The genetic and cultural transmission of alcohol use, alcoholism, cigarette smoking and coffee drinking: a review and an example using a log linear cultural transmission model.. Br J Addict, 80(3), 269 - 279.
- Gurling HM (1984). Genetic epidemiology in medicine--recent twin research.. Br Med J (Clin Res Ed), 288(6410), 3 - 5.
- Gurling HM, Oppenheim BE, Murray RM (1984). Depression, criminality and psychopathology associated with alcoholism: evidence from a twin study.. Acta Genet Med Gemellol (Roma), 33(2), 333 - 339.
- Gurling HM, Reveley MA, Murray RM (1984). Increased cerebral ventricular volume in monozygotic twins discordant for alcoholism.. Lancet, 1(8384), 986 - 988.
- Murray RM, Clifford C, Gurling HM, Topham A, Clow A, Bernadt M (1983). Current genetic and biological approaches to alcoholism.. Psychiatr Dev, 1(2), 179 - 192.
- Murray RM, Clifford CA, Gurling HM (1983). Twin and adoption studies. How good is the evidence for a genetic role?. Recent Dev Alcohol, 1, 25 - 48.
- Murray RM, Gurling HM (1982). Alcoholism: polygenic influence on a multifactorial disorder.. Br J Hosp Med, 27(4), 328 - 334.
- Gurling HM, Murray RM, Clifford CA (1981). Investigations into the genetics of alcohol dependence and into its effects on brain function.. Prog Clin Biol Res, 69 Pt C, 77 - 87.
- Reveley AM, Gurling HM, Murray RM (1981). Mortality and psychosis in twins.. Prog Clin Biol Res, 69 Pt B, 175 - 178.
- Clifford CA, Fulker DW, Gurling HM, Murray RM (1981). Preliminary findings from a twin study of alcohol use.. Prog Clin Biol Res, 69 Pt C, 47 - 52.
- Reveley MA, Gurling HM, Glass I, Glover V, Sandler M (1980). Platelet gamma-aminobutyric acid-aminotransferase and monoamine oxidase in schizophrenia.. Neuropharmacology, 19(12), 1249 - 1250.
- Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira AC, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S C, D G, H M M, P B M, O B, A D (). Support of association between BRD1 and both schizophrenia and bipolar affective disorder.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, , - .
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