Prof Geoff Laurent

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Personal Profile

Name: Geoff Laurent Email: g.laurent@ucl.ac.uk
Title: Prof Tel:
Department: Div of Medicine Fax:
Position: Emeritus Professor of Pulmonary Biochemistry Address: , , ,
Research Domain: Basic Life Sciences, Personalised Medicine Web Page:  

Profile

Research Description

Professor Laurent is the Director of the Centre for Respiratory Research at University College London where he directs a team of scientists and physicians conducting research into basic aspects of the mechanisms of inflammation and remodelling, as well as programmes in translational reseach leading to clinical trials in collaboration with industry. He has published over 200 articles in international journals of biomedical research and was recently awarded the European Respiratory Societies Presidential Award for his contribution to lung science. He is the Editor-in-Chief of the International Journal of Biochemistry and Cell Biology, an associate editor of the American Journal of Respiratory Cell and Molecular Biology and has edited several books including a four volume Encyclopedia of Respiratory Medicine. In June 2006 he was appointed a Fellow of the Academy of Medical Sciences. He was appointed Director of the European Respiratory Society Lung Science Conference in August 2006. He is also the President of the British Association for Lung Research.

Research Activities

Investigating the mechanisms, inflammation and tissue remodelling in chronic diseases.

Education Description

UCL Collaborators

External Collaborators

Publications

    2012

    • Wilkosz S, Edwards LA, Bielsa S, Hyams C, Taylor A, Davies RJ, Laurent GJ, Chambers RC, Brown JS, Lee YC (2012). Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae.. Am J Respir Cell Mol Biol, 46(2), 180 - 187. doi:10.1165/rcmb.2011-0182OC
    • Pechkovsky DV, Prêle CM, Wong J, Hogaboam CM, McAnulty RJ, Laurent GJ, Zhang SS, Selman M, Mutsaers SE, Knight DA (2012). STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF.. Am J Pathol, 180(4), 1398 - 1412. doi:10.1016/j.ajpath.2011.12.022

    2011

    • Manunta MD, McAnulty RJ, Tagalakis AD, Bottoms SE, Campbell F, Hailes HC, Tabor AB, Laurent GJ, O'Callaghan C, Hart SL (2011). Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.. PLoS One, 6(10), e26768 - . doi:10.1371/journal.pone.0026768
    • Kargul J, Laurent GJ (2011). Liver growth, development and disease-New research revealing new horizons. INT J BIOCHEM CELL B, 43(2), 171 - 171. doi:10.1016/j.biocel.2010.11.016
    • Kargul J, Laurent GJ (2011). Organelles in Focus launch. INT J BIOCHEM CELL B, 43(4), 459 - 459. doi:10.1016/j.biocel.2010.09.006
    • Kargul J, Laurent GJ (2011). Targeting metabolic pathways for cancer therapy. INT J BIOCHEM CELL B, 43(7), 947 - 947. doi:10.1016/j.biocel.2011.04.008

    2010

    • Heightman MJ, Booth HL, Laurent GJ, Hill MR, McAnulty RM (2010). TISSUE INHIBITOR OF METALLOPROTEINASE-3 (TIMP3) PROTECTS AGAINST INFLAMMATORY PROCESSES IN INTERSTITIAL LUNG DISEASE (ILD). doi:10.1136/thx.2010.150896.3
    • Kargul J, Laurent GJ (2010). E-i-C editorial: Structure and function of the SOX transcription factors. INT J BIOCHEM CELL B, 42(3), 375 - 375. doi:10.1016/j.biocel.2009.12.019
    • Eickelberg O, Laurent GJ (2010). The Quest for the Initial Lesion in Idiopathic Pulmonary Fibrosis Gene Expression Differences in IPF Fibroblasts. AM J RESP CELL MOL, 42(1), 1 - 2. doi:10.1165/rcmb.2009-0245ED
    • Kargul J, Laurent GJ (2010). Mechanisms of inflammation. INT J BIOCHEM CELL B, 42(4), 479 - 479. doi:10.1016/j.biocel.2010.02.001
    • Kargul J, Laurent GJ (2010). MicroRNAs in development and disease. INT J BIOCHEM CELL B, 42(8), 1233 - 1233. doi:10.1016/j.biocel.2010.04.001

    2009

    • Kargul J, Laurent GJ (2009). Mitochondria matter: New concepts of dynamics and roles in pathophysiology. INT J BIOCHEM CELL B, 41(10), 1747 - 1747. doi:10.1016/j.biocel.2009.06.005
    • Kargul J, Laurent GJ (2009). Darwin's legacy in modern bioscience. INT J BIOCHEM CELL B, 41(2), 249 - 249. doi:10.1016/j.biocel.2008.10.014
    • Aguilar S, Scotton C, Nye E, Stamp G, Laurent G, Bonnet D, Janes S (2009). Bone Marrow Stem Cells Expressing Keratinocyte Growth Factor via an Inducible Lentivirus Protects against Bleomycin-induced Pulmonary Fibrosis. PLoS One, 4(11), e8013 - .
    • Atzori L, Lucatelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of Proteinase Activated Receptor-1 Signaling in Mice Confers Protection from fMLP-induced Goblet Cell Metaplasia.. American Journal of Respiratory Cell and Molecular Biology, , - .
    • Scotton CJ, Krupiczojc MA, Koenigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. Journal of Clinical Investigation, 119(9), 2550 - 2563.
    • Kargul J, Laurent GJ (2009). Epigenetics and human disease. INT J BIOCHEM CELL B, 41(1), 1 - 1. doi:10.1016/j.biocel.2008.09.017

    2008

    • Laurent GJ, McAnulty RJ, Hill MR, Chambers RC (2008). Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis. Proc Am Thorac Soc, 5(3), 311 - 315.
    • Kargul J, Laurent GJ (2008). Proteases and antiproteases in immune defense, tissue homeostasis and development. INT J BIOCHEM CELL B, 40(6-7), 1065 - 1065. doi:10.1016/j.biocel.2008.02.023

    2007

    • Kargul J, Laurent GJ (2007). Cancer research: Translating scientific advances into taming the global disease. INT J BIOCHEM CELL B, 39(7-8), 1277 - 1277. doi:10.1016/j.biocel.2007.04.001
    • Chua F, Dunsmore SE, Clingen PH, Mutsaers SE, Shapiro SD, Segal AW, Roes J, Laurent GJ (2007). Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. American Journal of Pathology, 170(1), 65 - 74. doi:10.2353/ajpath.2007.060352
    • Laurent GJ, Chambers RC, Hill MR, McAnulty R (2007). Regulation of matrix turnover: fibroblasts, forces, factors and fibrosis. Biochemical Society Transactions, 35(4), 647 - 651.
    • Maher TM, Wells AU, Laurent GJ (2007). Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?. Eur Respir J, 30(5), 835 - 839. doi:10.1183/09031936.00069307

    2006

    • Laurent GJ (2006). Signalling networks in focus. INT J BIOCHEM CELL B, 38(7), 1023 - 1023. doi:10.1016/j.biocel.2006.03.001
    • Kargul J, Laurent GJ (2006). Diabetes: New challenges for the control of disease globalisation. INT J BIOCHEM CELL B, 38(5-6), 685 - 686. doi:10.1016/j.biocel.2005.12.010
    • Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta(6) integrin-dependent TGF-beta activation and promotes acute lung injury. Journal of Clinical Investigation, 116(6), 1606 - 1614.
    • Laurent GJ (2006). Signalling networks in focus. INT J BIOCHEM CELL B, 38(4), 491 - 491. doi:10.1016/j.biocel.2005.11.010
    • Chua F, Laurent GJ (2006). Neutrophil elastase: mediator of extracellular matrix destruction and accumulation.. Proc Am Thorac Soc, 3(5), 424 - 427. doi:10.1513/pats.200603-078AW
    • Jenkins G, Su X, Su G, Scotton C, Camerer E, Laurent GJ, David G, Chambers R, Matthay M, Sheppard D (2006). Ligitation of protease-activated receptor 1 enhances αvβ6 integrin-dependent TGFβ activation and promotes acute lung injury. Journal of Clinical Investigation, 116(6), 1606 - 1614. doi:10.1172/JCI27183
    • Lipman MCI (2006). Human immunodeficiency virus. In (Ed.), Encyclopedia of Respiratory Medicine (pp. - ). : Elsevier.
    • Chambers RC (2006). Proteinase-activated receptors. In Shapiro SD, Laurent GJ (Ed.), Encyclopaedia of Respiratory Medicine (pp. - ). : Elsevier.
    • Bellingan GJ, Al-Khafaji A (2006). Ventilator associated pneumonia. In Laurent GJ, Shapiro SD (Ed.), Encyclopedia of Respiratory Medicine (pp. 464 - 469). : Elsevier.
    • Bellingan GJ, Finney S (2006). Acute Respiratory Distress Syndrome. In Laurent GJ, Shapiro S (Ed.), Encylcopedia of Respiratory Medicine (pp. 11 - 19). : Elsevier.
    • Chambers RC (2006). Thrombin. In Shapiro SD, Laurent GJ (Ed.), Encyclopaedia of Respiratory Medicine (pp. - ). : Elsevier.
    • Hill MR, Papafili A, Booth H, Lawson P, Hubner M, Beynon H, Read C, Lindahl G, Marshall RP, McAnulty RJ, Laurent GJ (2006). Functional prostaglandin-endoperoxide synthase 2 polymorphism predicts poor outcome in sarcoidosis. American Journal of Respiratory and Critical Care Medicine, 174(8), 915 - 922. doi:10.1164/rccm.200512-1839OC
    • Wu JY, Vlastos AT, Pelte MFC, M A B, A K, K H L, G I-F, I (2006). Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. International Journal of Cancer, 118(5), 1215 - 1226.

    2005

    • Laurent GJ (2005). Muscle wasting: On the brink of new therapies. INT J BIOCHEM CELL B, 37(10), 1931 - 1931. doi:10.1016/j.biocel.2005.06.020
    • Laurent GJ (2005). No bit PARt for PAR-1. AM J RESP CELL MOL, 33(3), 213 - 215. doi:10.1165/rcmb.F304
    • Chua F, Gauldie J, Laurent GJ (2005). Pulmonary fibrosis: searching for model answers.. Am J Respir Cell Mol Biol, 33(1), 9 - 13. doi:10.1165/rcmb.2005-0062TR
    • DeGiorgio-Miller AM, Treharne LH, McAnulty RJ, ColeridgeSmith PD, Laurent GJ, Herrick SE (2005). Procollagen type I gene expression and cell proliferation is increased in lipodermatosclerosis. British Journal of Dermatology, 152(2), 242 - 249.
    • Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis.. American Journal Of Pathology, 166(5), 1353 - 1365..
    • Blanc-Brude O, Archer F, Leoni P, Derian C, Bolsover SR, Laurent GJ, Chambers RC (2005). Factor Xa stimulates fibroblast procollagen production, proliferation and calcium signaling via PAR1 activation. Experimental Cell Research, 304(1), 16 - 27.
    • Chua F, Sly PD, Laurent GJ (2005). Pediatric lung disease: from proteinases to pulmonary fibrosis.. Pediatr Pulmonol, 39(5), 392 - 401. doi:10.1002/ppul.20171

    2004

    • Lindahl GE, Shiwen X, Chambers RC, Denton CP, Abraham DJ, Black CM, Laurent GJ (2004). DNA BINDING-ACTIVITY OF CCAAT-BINDING FACTOR (CBF) IS STRONGLY ENHANCED IN ACTIVATED LUNG FIBROBLASTS FROM PATENTS WITH SYSTEMIC SCLEROSIS. RHEUMATOLOGY, 43, 98 - 99.
    • Laurent GJ, Radola BJ, Breen CG (2004). A case of scientific fraud.. The International Journal of Biochemistry and Cell Biology, 36(11), 2097 - .
    • Laurent GJ (2004). Special issue on "modulatory adhesion molecules in tissue homeostasis" - Editorial. INT J BIOCHEM CELL B, 36(6), 959 - 959. doi:10.1016/j.biocel.2004.02.008
    • Laurent GJ (2004). Directed issue on stem cells. INT J BIOCHEM CELL B, 36(4), 553 - 553. doi:10.1016/j.biocel.2003.11.010
    • Hodges RJ, Jenkins RG, Wheeler-Jones CPD, Copeman DM, Bottoms SE, Bellingan GJ, Nanthakumar CB, Laurent GJ, Hart SL, Foster ML, McAnulty RJ (2004). Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production.. American Journal Of Pathology, 165(5), 1663 - 1676.
    • Papakrivopoulou J, Lindahl GE, Bishop JE, Laurent GJ (2004). Differential roles of extracellular signal-regulated kinase 1/2 and p38MAPK in mechanical load-induced procollagen alpha1(I) gene expression in cardiac fibroblasts.. Cardiovascular Research, 61(4), 736 - 744.
    • Marshall RP, Gohlke P, Chambers RC, Howell DC, Bottoms SE, Unger T, McAnulty RJ, Laurent GJ (2004). Angiotensin II and the fibroproliferative response to acute lung injury. American Journal of Physiology - Lung Cellular and Molecular Physiology, 286(1), L156 - L164.
    • Hill MR, Briggs L, Montano MM, Estrada A, Laurent GJ, Selman M, Pardo A (2004). Promoter variants in tissue inhibitor of metalloproteinase-3 (TIMP-3) protect against susceptibility in pigeon breeders' disease.. Thorax, 59(7), 586 - 590. doi:10.1136/thx.2003.012690
    • Laurent GJ (2004). Getting grant applications funded: lessons from the past and advice for the future.. Thorax, 59(12), 1010 - 1011.
    • Mutsaers SE, McAnulty RJ, Laurent GJ, Knight DA (2004). Evaluation of experimental models of idiopathic pulmonary fibrosis. Drug discovery today:Disease models, 1(3), 329 - 336.
    • Atzori L, Chua F, Dunsmore SE, Willis D, Barbarisi M, McAnulty RJ, Laurent GJ (2004). Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol.. Thorax, 59(3), 217 - 223.
    • Moffatt JD, Page CP, Laurent GJ (2004). Shooting for PARs in lung diseases.. Current Opinion in Pharmacology, 4(3), 221 - 229.
    • Moodley YP, Caterina P, Scaffidi AK, Misso NL, Papadimitriou JM, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA (2004). Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis.. The Journal of Pathology, 202(4), 486 - 495.
    • Laurent GJ (2004). Special Issue on HIV.. The International Journal of Biochemistry and Cell Biology, 36(9), 1665 - .
    • Laurent GJ (2004). Autophagy: too much or too little recycling in the cell?. INT J BIOCHEM CELL B, 36(12), 2364 - 2364. doi:10.1016/j.biocel.2004.06.011

    2003

    • Laurent GJ (2003). Directed issue: renin-angiotensin systems: State of the art. INT J BIOCHEM CELL B, 35(6), 757 - 757. doi:10.1016/S1357-2725(03)00002-5
    • Laurent GJ (2003). Editorial: Directed issue on proteasomes. INT J BIOCHEM CELL B, 35(5), 545 - 545. doi:10.1016/S1357-2725(03)00044-X
    • Moodley YP, Scaffidi AK, Misso NL, Keerthisingam C, McAnulty RJ, Laurent GJ, Mutsaers SE, Thompson PJ, Knight DA (2003). Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation. American Journal Of Pathology, 163(1), 345 - 354.
    • Jenkins RG, Meng QH, Hodges RJ, Lee LK, Bottoms SE, Laurent GJ, Willis D, Ayazi Shamlou P, McAnulty RJ, Hart SL (2003). Formation of LID vector complexes in water alters physicochemical properties and enhances pulmonary gene expression in vivo.. Gene Therapy, 10(12), 1026 - 1034. doi:10.1038/sj.gt.3301963
    • Moodley Y, Rigby P, Bundell C, Bunt S, Hayashi H, Misso N, McAnulty R, Laurent G, Scaffidi A, Thompson P, Knight D (2003). Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36.. American Journal Of Pathology, 162(3), 771 - 779.
    • Yuben PM, Misso NL, Scaffidi AK, Fogel-Petrovic M, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA (2003). Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs. American Journal of Respiratory Cell and Molecular Biology, 29(4), 490 - 498.
    • Jenkins RG, McAnulty RJ, Hart SL, Laurent GJ (2003). Pulmonary Gene Therapy. Realistic hope for the future, or false dawn in the promised land?. Monaldi Archives of Chest Disease, 59, 17 - 24.
    • Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA (2003). Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. American Journal of Pathology, 162(2), 533 - 546.
    • Dik WA, McAnulty RJ, Versnel MA, Naber BA, Zimmermann LJ, Laurent GJ, Mutsaers SE (2003). Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats. Thorax, 58(9), 765 - 771.
    • Jenkins RG, McAnulty RJ, Hart SL, Laurent GJ (2003). Pulmonary Gene Therapy. Realistic hope for the future, or false dawn in the promised land?. Monaldi Arch Chest Dis, 59(1), 21 - 28.

    2002

    • Laurent GJ (2002). Molecular and cellular mechanisms of aging. INT J BIOCHEM CELL B, 34(11), 1317 - 1317.
    • Lindahl GE, Chambers RC, Papakrivopoulou J, Dawson SJ, Jacobsen MC, Bishop JE, Laurent GJ (2002). Activation of fibroblast procollagen alpha 1 (I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter. Journal of Biological Chemistry, 277(8), 6153 - 6161. doi:10.1074/jbc.M108966200
    • Bellingan GJ, Xu P, Cooksley H, Cauldwell H, Shock A, Bottoms S, Haslett C, Mutsaers SE, Laurent GJ (2002). Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. Journal of Experimental Medicine, 196(11), 1515 - 1521. doi:10.1084/jem.20011794
    • Sulaiman H, Dawson L, Laurent GJ, Bellingan GJ, Herrick SE (2002). Role of plasminogen activators in peritoneal adhesion formation. Biochemical Society Transactions, 30(2), 126 - 131.
    • Chambers RC, Laurent GJ (2002). Coagulation cascade proteases and tissue fibrosis. Biochemical Society Transactions, 30(2), 194 - 200.
    • McAnulty RJ, Laurent GJ (2002). Fibroblasts. In Barnes PJ, Drazen JM, Rennard S, Thomson NC (Ed.), Asthma and COPD Basic mechanisms and clinical management (pp. 139 - 144). : Academic Press.
    • Scaffidi AK, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA (2002). Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts. British Journal of Pharmacology, 136(5), 793 - 801.
    • Howell DC, Laurent GJ, Chambers RC (2002). Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochemical Society Transactions, 30(2), 211 - 216.
    • Marshall RP, Webb S, Hill MR, Humphries SE, Laurent GJ (2002). Genetic polymorphisms associated with susceptibility and outcome in ARDS. Chest, 121(3 Supp), 68S - 69S.
    • Jenkins G, Hart SL, Hodges RJ, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ (2002). Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung. Chest, 121(3 Supp), 102S - 104S.
    • Papafili A, Hill MR, Brull DJ, McAnulty RJ, Marshall RP, Humphries SE, Laurent GJ (2002). Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(10), 1631 - 1636. doi:10.1161/01.ATV.0000030340.80207.C5
    • Dunsmore SD, Chambers RC, Laurent GJ (2002). Matrix Proteins.. In Gibson J, Geddes D, Costabel U, Sterk P, Corrin B (Ed.), Respiratory Medicine 3rd Edition (pp. 82 - 92). : Harcourt Health Sciences.
    • Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, Humphries SE, Hill MR, Laurent GJ (2002). Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 166(5), 646 - 650. doi:10.1164/rccm.2108086
    • Foley-Comer AJ, Herrick SE, Al Mishlab T, Prele CM, Laurent GJ, Mutsaers SE (2002). Evidence for incorporation of free-floating mesothelial cells as a mechanism of serosal healing. Journal of Cell Science, 115(7), 1383 - 1389.
    • Simler NR, Howell DC, Marshall RP, Goldsack NR, Hasleton PS, Laurent GJ, Chambers RC, Egan JJ (2002). The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats. European Respiratory Journal, 19(6), 1124 - 1127.

    2001

    • Keerthisingam CB, Jenkins RG, Harrison NK, Hernandez-Rodriguez NA, Booth H, Laurent GJ, Hart SL, Foster ML, McAnulty RJ (2001). Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. American Journal Of Pathology, 158(4), 1411 - 1422.
    • Coker RK, Laurent GJ, Jeffery PK, duBois RM, Black CM, McAnulty RJ (2001). Localisation of transforming growth factor beta1 and beta3 mRNA transcripts in normal and fibrotic human lung.. Thorax, 56(7), 549 - 556.
    • Blanc-Brude OP, Chambers RC, Leoni P, Dik WA, Laurent GJ (2001). Factor Xa is a fibroblast mitogen via binding to effector-cell protease receptor-1 and autocrine release of PDGF. American Journal of Physiology - Cell Physiology, 281(2), C681 - C689.
    • Dabbagh K, Laurent GJ, Shock A, Leoni P, Papakrivopoulou J, Chambers RC (2001). Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways. Journal of Cellular Physiology, 186(1), 73 - 81.
    • Howell DC, Goldsack NR, Marshall RP, McAnulty RJ, Starke R, Purdy G, Laurent GJ, Chambers RC (2001). Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. American Journal Of Pathology, 159(4), 1383 - 1395.
    • Sulaiman H, Gabella G, Davis C, Mutsaers SE, Boulos P, Laurent GJ, Herrick SE (2001). Presence and distribution of sensory nerve fibers in human peritoneal adhesions. Annals of Surgery, 234(2), 256 - 261.
    • Warn R, Harvey P, Warn A, Foley-Comer A, Heldin P, Versnel M, Arakaki N, Daikuhara Y, Laurent GJ, Herrick SE, Mutsaers SE (2001). HGF/SF induces mesothelial cell migration and proliferation by autocrine and paracrine pathways. Experimental Cell Research, 267(2), 258 - 266.

    2000

    • Marshall RP, Puddicombe A, Cookson WO, Laurent GJ (2000). Adult familial cryptogenic fibrosing alveolitis in the United Kingdom. THORAX, 55(2), 143 - 146.
    • Marshall RP, McAnulty RJ, Laurent GJ (2000). Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor. American Journal of Respiratory and Critical Care Medicine, 161(6), 1999 - 2004.
    • Jenkins RG, Herrick SE, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ, Hart SL (2000). An integrin-targetted non-viral vector for pulmonary Gene Therapy. Gene Therapy, 7, 393 - 400.
    • Sulaiman H, Gabella G, Davis C, Mutsaers SE, Boulos P, Laurent GJ, Herrick SE (2000). Growth of nerve fibres into murine peritoneal adhesions. The Journal of Pathology, 192(3), 396 - 403.
    • Chambers RC, Leoni P, Blanc-Brude OP, Wembridge DE, Laurent GJ (2000). Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. Journal of Biological Chemistry, 275(45), 35584 - 35591.
    • Akers IA, McAnulty RJ, Laurent GJ (2000). Fibroblasts and myofibroblasts. In Page CP, Banner KH, Spina D (Ed.), Cellular mechanisms in airway inflammation (pp. 159 - 198). : Birkhauser Verlag.
    • Marshall RP, Bellingan G, Webb S, Puddicombe A, Goldsack N, McAnulty RJ, Laurent GJ (2000). Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome. American Journal of Respiratory and Critical Care Medicine, 162(5), 1783 - 1788.
    • (2000). Human peritoneal adhesions are highly cellular, innervated and vascularised. The Journal of Pathology, 192(1), 62 - 72.
    • Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, Laurent GJ, McAnulty RJ (2000). Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. American Journal of Physiology - Lung Cellular and Molecular Physiology, 278(1), L193 - L201.
    • Bellingan GM, R L, G (2000). Fibrosis in ARDS: how close is the link between inflammation and fibroproliferation?. In Vincent JL (Ed.), Yearbook of Intensive Care and Emergency Medicine (pp. 217 - 224). : Springer.
    • Bellingan GJ, Laurent GJ (2000). Acute Lung injury; from Inflammation to Repair..
    • Chambers RC (2000). Role of Thrombin in Acute Lung Injury.. In Bellingan GJ, Laurent GJ (Ed.), Mechanisms of Acute Lung Injury (pp. 115 - 128). : IOS Press.
    • Herrick SE, Mutsaers SE, Ozua P, Sulaiman H, Omer A, Boulos P, Foster ML, Laurent GJ (2000). Human peritoneal adhesions are highly cellular, innervated, and vascularized. The Journal of Pathology, 192(1), 67 - 72.

    1999

    • Jenkins RG, Hart SL, Chambers RC, Herrick SE, Kinnon C, Laurent GJ, McAnulty RJ (1999). Enhanced gene delivery to the lung using a novel integrin mediated vector.
    • Parsons M, Kessler E, Laurent GJ, Brown RA, Bishop JE (1999). Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen C-proteinase. Experimental Cell Research, 252(2), 319 - 331.
    • Laurent GJ, McAnulty RJ, Chambers RC, Keerthisingam CB (1999). Regulation of procollagen genes. From forces to factors.. Journal of Chemical Sciences, 111(1), 291 - 299. doi:10.1007/BF02869918

    1998

    • Goldsack NR, Chambers RC, Dabbagh K L, G J (1998). Molecules in Focus: Thrombin. Int J Biochem Cell Biol., 30.(6), 641 - 646. doi:10.1016/S1357-2725(98)00011-9
    • Coker RK, Laurent GJ (1998). Pulmonary fibrosis: cytokines in the balance. European Respiratory Journal, 11(6), 1218 - 1221.
    • Chambers RC, Laurent GJ, Westergren T (1998). Cadmium inhibits proteoglycan and procollagen production by cultured human lung fibroblasts. AM J RESPIR CELL MOL BIOL, 19(3), 498 - 506.
    • Mutsaers SE, Harrison NK, McAnulty RJ, Liao JY, Laurent GJ, Musk AW (1998). Fibroblast mitogens in bronchoalveolar lavage (BAL) fluid from asbestos-exposed subjects with and without clinical evidence of asbestosis: no evidence for the role of PDGF, TNF-alpha, IGF-1, or IL-1 beta. The Journal of Pathology, 185(2), 199 - 203.
    • Coker RK, Laurent GJ, Dabbagh K, Dawson J, McAnulty RJ (1998). A novel transforming growth factor beta2 antisense transcript in mammalian lung. Biochemical Journal, 332(Pt 2), 297 - 301.
    • Rogers DF, Laurent GJ (1998). New ideas on the pathophysiology and treatment of lung disease. THORAX, 53(3), 200 - 203.
    • Goldsack NR, Chambers RC, Dabbagh K, Laurent GJ (1998). Thrombin. INT J BIOCHEM CELL BIOL, 30(6), 641 - 646.
    • Mutsaers SE, Foster ML, Chambers RC, Laurent GJ, McAnulty RJ (1998). Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats. American Journal of Respiratory Cell and Molecular Biology, 18(5), 611 - 619.
    • Dabbagh K, Chambers RC, Laurent GJ (1998). From clot to collagen: coagulation peptides in interstitial lung disease [editorial]. European Respiratory Journal, 11(5), 1002 - 1005.
    • Dabbagh K, Laurent GJ, McAnulty RJ, Chambers RC (1998). Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism. Thrombosis and Haemostasis, 79(2), 405 - 409.
    • Chambers RC, Dabbagh K, McAnulty RJ, Gray AJ, Blanc-Brude OP, Laurent GJ (1998). Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochemical Journal, 333(Pt 1), 121 - 127.
    • Mutsaers SE, Marshall RP, Goldsack NR, Laurent GJ, McAnulty RJ (1998). Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats. Pulmonary Pharmacology and Therapeutics, 11(2-3), 221 - 225.

    1997

    • Coker RK, Laurent GJ (1997). Anticytokine approaches in pulmonary fibrosis: bringing factors into focus. THORAX, 52(3), 294 - 296.
    • Chambers RC, Laurent GJ (1997). The Lung.. In Comper WD (Ed.), Structure and Function of the Extracellular Matrix (pp. 378 - 409). : Harwood Academic Publishers.
    • Chambers RC, Laurent GJ (1997). Putative Role for Cadmium in the Pathogenesis of Emphysema.. In Mohr U (Ed.), Correlations between in vitro and in vivo Investigations in Inhalation Toxicology (pp. 365 - 379). : ILSI Press.
    • Marshall RP, McAnulty RJ, Laurent GJ (1997). The pathogenesis of pulmonary fibrosis: is there a fibrosis gene?. The International Journal of Biochemistry and Cell Biology, 29(1), 107 - 120.
    • Chambers RC, Laurent GJ (1997). Collagens.. In Crystal RG, West JB, Weibel ER, Barnes PJ (Ed.), The Lung: Scientific Foundations (pp. 709 - 727). : Lippincott-Raven.
    • McAnulty RJ, Hernandez-Rodriguez NA, Mutsaers SE, Coker RK, Laurent GJ (1997). Indomethacin suppresses the anti-proliferative effects of transforming growth factor-beta isoforms on fibroblast cell cultures.. Biochemical Journal, 321(Pt 3), 639 - 643.
    • Mutsaers SE, McAnulty RJ, Laurent GJ, Versnel MA, Whitaker D, Papadimitriou JM (1997). Cytokine regulation of mesothelial cell proliferation in vitro and in vivo. European Journal of Cell Biology, 72(1), 24 - 29.
    • Coker RK, Laurent GJ, Shahzeidi S, Lympany PA, DuBois RM, Jeffery PK, McAnulty RJ (1997). Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. American Journal Of Pathology, 150(3), 981 - 991.
    • Mutsaers SE, Bishop JE, McGrouther G, Laurent GJ (1997). Mechanisms of tissue repair: from wound healing to fibrosis. INT J BIOCHEM CELL BIOL, 29(1), 5 - 17.

    1996

    • Coker RK, Laurent GJ, Shahzeidi S, Hernández-Rodríguez NA, Pantelidis P, du Bois RM, Jeffery PK, McAnulty RJ (1996). Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lung.. Eur Respir J, 9(12), 2501 - 2507.
    • Dawes KE, Cambrey AD, Campa JS, Bishop JE, McAnulty RJ, Peacock AJ, Laurent GJ (1996). Changes in collagen metabolism in response to endothelin-1: evidence for fibroblast heterogeneity.. Int J Biochem Cell Biol, 28(2), 229 - 238.

    1995

    • GRAY AJ, BISHOP JE, REEVES JT, MECHAM RP, LAURENT GJ (1995). PARTIALLY DEGRADED FIBRIN(OGEN) STIMULATES FIBROBLAST PROLIFERATION IN-VITRO. AM J RESP CELL MOL, 12(6), 684 - 690.
    • Butt RP, Laurent GJ, Bishop JE (1995). Collagen production and replication by cardiac fibroblasts is enhanced in response to diverse classes of growth factors.. Eur J Cell Biol, 68(3), 330 - 335.
    • Bishop JE, Laurent GJ (1995). Collagen turnover and its regulation in the normal and hypertrophying heart.. Eur Heart J, 16 Suppl C, 38 - 44.
    • McAnulty RJ, Chambers RC, Laurent GJ (1995). Regulation of fibroblast procollagen production: Transforming growth factor-β1 induces prostaglandin E2 but not procollagen synthesis via a pertussis toxin sensitive G-protein.. Biochemical Journal, 307, 63 - 68.
    • Hernandez Rodriguez NA, Cambrey AD, Harrison NK, Chambers RC, Gray AJ, Southcott AM, duBois AM, Black CM, Scully MF, McAnulty RJ, Laurent GJ (1995). Role of thrombin in pulmonary fibrosis.. The Lancet, 346, 1071 - 1073.
    • Bishop JE, Rhodes S, Laurent GJ, Low RB, Stirewalt WS (1995). The regulation of collagen deposition in the hypertrophying heart.. Ann N Y Acad Sci, 752, 236 - 239.
    • Mays PK, McAnulty RJ, Campa JS, Laurent GJ (1995). Age-related alterations in collagen and total protein metabolism determined in cultured rat dermal fibroblasts: age-related trends parallel those observed in rat skin in vivo.. Int J Biochem Cell Biol, 27(9), 937 - 945.
    • Gray AJ, Park PW, Broekelmann TJ, Laurent GJ, Reeves JT, Stenmark KR, Mecham RP (1995). The mitogenic effects of the B beta chain of fibrinogen are mediated through cell surface calreticulin.. J Biol Chem, 270(44), 26602 - 26606.
    • Winlove CP, Bishop JE, Chambers RC, Laurent GJ (1995). The structure and function of extracellular matrix in the pulmonary vasculature.. In Bishop JE, Reevs JT, Laurent GJ (Ed.), The Pulmonary Vasculature (pp. 21 - 46). : Portland Press.
    • Butt RP, Laurent GJ, Bishop JE (1995). Mechanical load and polypeptide growth factors stimulate cardiac fibroblast activity.. Ann N Y Acad Sci, 752, 387 - 393.

    1994

    • Chambers RC, McAnulty RJ, Shock A, Campa JS, NewmanTaylor AJ, Laurent GJ (1994). Cadmium selectively inhibits fibroblast procollagen production and proliferation.. American Journal of Physiology - Lung Cellular and Molecular Physiology, 267, 300 - 308.

    1991

    • Shock A, Rabe KF, Dent G, Chambers RC, Gray AJ, Chung KF, Barnes PJ, Laurent GJ (1991). Eosinophils adhere to and stimulate replication of lung fibroblasts in vitro.. Clinical and Experimental Neurology, 86, 185 - 190.