Prof Glen Jeffery

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Personal Profile

Name: Glen Jeffery Email: g.jeffery@ucl.ac.uk
Title: Prof Tel: 020 7608 6837
Department: Inst Ophthalmology - Visual Neuroscience Fax: 020 7608 6850
Position: Professor of Neuroscience Address: Institute of Ophthalmology, UCL, 11-43 Bath Street, London , EC1V 9EL
Research Domain: Experimental Medicine, Neuroscience, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

Retinal structure, development and visual areas of the brain. Comparative evolution of the brain

Research Activities

Vision

Visual function and disease

Education Description

UCL Collaborators

Dr Martin Stocker; Prof David Hunt; Prof Tom Salt; Prof Semir Zeki; Prof Andrew Webster; Prof Jim Bowmaker

External Collaborators

Publications

    2013

    • Kam JH, Lenassi E, Malik TH, Pickering MC, Jeffery G (2013). Complement Component C3 Plays a Critical Role in Protecting the Aging Retina in a Murine Model of Age-Related Macular Degeneration.. Am J Pathol, , - . doi:10.1016/j.ajpath.2013.04.008

    2009

    • Lundh VL, Kam JH, Bainbridge J, Catchpole I, Gough G, Coffey P, Jeffery G (2009). Complement factor h is critical in the maintenance of retinal perfusion. Am.J.Pathol., 175(1), 412 - 421.
    • Al Hussaini H, Schneiders M, Lundh P, Jeffery G (2009). Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells. Exp.Eye Res., 88(3), 610 - 612.
    • Adams T, Shahabi G, Hoh-Kam J, Jeffery G (2009). Held under arrest: Many mature albino RPE cells display polyploid features consistent with cell cycle retention.. Experimental Eye Reseatch, Epub ahead of pr, - .
    • Neveu MM, Jeffrey G, Moore AT, Dakin SC (2009). Deficits in local and global motion perception arising from abnormal eye movements. Journal of Vision, 9(4), 1 - 15. doi:10.1167/9.4.9
    • Cottril P, Davis W, Semo M, Bowmaker J, Hunt D, Jeffery G (2009). Developmental dynamics of cone photoreceptors in the eel. BMC Developmental Biology, ebub, - .

    2008

    • Bowmaker JK, Semo M, Hunt DM, Jeffery G (2008). Eel visual pigments revisited: the fate of retinal cones during metamorphosis. Vis.Neurosci., 25(3), 249 - 255.
    • Jeffery G, Levitt JB, Cooper HM (2008). Segregated hemispheric pathways through the optic chiasm distinguish primates from rodents. Neuroscience, 157(3), 637 - 643.
    • Manuel M, Pratt T, Liu M, Jeffery G, Price DJ (2008). Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance. BMC.Dev.Biol., 8, 59 - .
    • Vugler AA, Semo M, Joseph A, Jeffery G (2008). Survival and remodeling of melanopsin cells during retinal dystrophy. Vis.Neurosci., 25(2), 125 - 138. doi:10.1017/S0952523808080309
    • Neveu MM, von dem HE, Morland AB, Jeffery G (2008). The fovea regulates symmetrical development of the visual cortex. J.Comp Neurol., 506(5), 791 - 800.
    • Al Hussaini H, Kam JH, Vugler A, Semo M, Jeffery G (2008). Mature retinal pigment epithelium cells are retained in the cell cycle and proliferate in vivo. Mol.Vis., 14, 1784 - 1791.

    2007

    • Semo N, Vugler AA, Jeffery G (2007). Paradoxical opsin expressing cells in the inner retina that are augmented following retinal degeneration. European Journal of Neuroscience, 25(8), 2296 - 2306. doi:10.1111/j.1460-9568.2007.05461.x
    • Stockman A, Sharpe LT, Tufail A, Kell PD, Ripamonti C, Jeffery G (2007). The effect of sildenafil citrate (Viagra®) on visual sensitivity. Journal of Vision, 8(7), 4,1 - 15. doi:10.1167/7.8.4
    • Tibber MS, Becker DL, Jeffery G (2007). Levels of transient gap junctions between the retinal pigment epithelium and the neuroblastic retina are influenced by catecholamines and correlate with patterns of cell production. The Journal of Comparative Neurology, 503(1), 128 - 134.
    • Neveu MM, Jeffery G (2007). Chiasm formation in man is fundamentally different from that in the mouse. Eye, 21(10), 1264 - 1270.
    • Cunea A, Jeffery G (2007). The ageing photoreceptor. Vis.Neurosci., 24(2), 151 - 155.

    2006

    • Tibber MS, Whitmore AV, Jeffery G (2006). Cell division and cleavage orientation in the developing retina are regulated by L-DOPA. The Journal of Comparative Neurology, 496(3), 369 - 381.
    • Lavado A, Jeffery G, Tovar V, de la Villa P, Montoliu L (2006). Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin. Journal of Neurochemistry, 96(4), 1201 - 1211.
    • Kotecha A, Izadi S, Jeffery G (2006). Age-related changes in the thickness of the human lamina cribrosa. The British journal of ophthalmology, 90(12), 1531 - 1534.
    • Stockman A, Sharpe LT, Smithson HE, Tufail A, Kell PD, Jeffery G (2006). Viagra® slows the visual response to flicker. Current Biology, 16(2), R44 - R45. doi:10.1016/j.cub.2006.01.016
    • Neveu MM, Holder GE, Ragge NK, Sloper JJ, Collin JR, Jeffery G (2006). Early midline interactions are important in mouse optic chiasm formation but are not critical in man: a significant distinction between man and mouse. European Journal of Neuroscience, 23(11), 3034 - 3042. doi:10.1111/j.1460-9568.2006.04827.x
    • Wu H, Cowing JA, Michaelides M, Wilkie SE, Jeffery G, Jenkins SA, Nazari MMY, Mester V, Bird AC, Robson AG, Holder GE, Moore AT, Hunt DM, Webster AR (2006). Mutation in the gene KCNV2, encoding a voltage-gated potassium channel subunit cause “cone dystrophy with a supernormal rod electroretinogram” in humans.. The American Journal of Human Genetics, 79(3), 574 - 579.
    • Kralj-Hans I, Tibber M, Jeffery G, Mobbs P (2006). Differential Effect of Dopamine on Mitosis in Early Postnatal Albino and Pigmented Rat Retinae. Journal of Neurobiology, 66(1), 47 - 55.

    2005

    • Sami DA, Saunders D, Thompson DA, Russell-Eggitt IM, Nischal KK, Jeffrey G, Dattani M, Clement RA, Liasis A, Taylor DS (2005). The achiasmia spectrum: congenitally reduced chiasmal decussation. Br J Ophthalmol, 89(10), 1311 - 1317. doi:10.1136/bjo.2005.068171
    • Pointer MA, Cheng CH, Bowmaker JK, Parry JW, Soto N, Jeffery G, Cowing JA, Hunt DM (2005). Adaptations to an extreme environment: retinal organisation and spectral properties of photoreceptors in Antarctic notothenioid fish. Journal of Experimental Biology, 208(Pt 12), 2363 - 2376.
    • Gimenez E, Lavado A, Jeffery G, Montoliu L (2005). Regional abnormalities in retinal development are associated with local ocular hypopigmentation. The Journal of Comparative Neurology, 485(4), 338 - 347.
    • Jeffery G, Erskine L (2005). Variation in the architecture and development of the vertebrate optic chiasm.. progress in Retinal and Eye Research, 24, 721 - 753.
    • Semo M, Llamosas MM, Foster RG, Jeffery G (2005). Melanopsin (Opn4) positive cells in the cat retina are randomly distributed across the ganglion cell layer. Visual Neuroscience, 22(1), 111 - 116.
    • Neveu MM, Holder GE, Sloper JJ, Jeffery G (2005). Optic chiasm formation in humans is independent of foveal development. European Journal of Neuroscience, 22(7), 1825 - 1829. doi:10.1111/j.1460-9568.2005.04364.x
    • Baker GE, Dovey M, Davda P, Guibal C, Jeffery G (2005). Protein kinase C immunoreactivity in the pigmented and albino rat retina. European Journal of Neuroscience, 22(10), 2481 - 2488.
    • von dem Hagen E, Huston G, Hoffmann P, Jeffery G, Morland A (2005). Retinal abnormalities in human albinism translates into a reduction of grey matter in the occipital cortex. European Journal of Neuroscience, 22, 2481 - 2488. doi:10.1111/j.1460-9568.2005.04433.x
    • Jeffery G, Erskine L (2005). Variations in the architecture and development of the vertebrate optic chiasm. Progress in Retinal and Eye Research, 24(6), 721 - 753.

    2004

    • Gimenez E, Lavado A, Giraldo P, Cozar P, Jeffery G, Montoliu L (2004). A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.. Pigment Cell Research, 17(4), 363 - 370.
    • Aijaz S, Erskine L, Jeffery G, Bhattacharya SS, Votruba M (2004). Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer.. Investigative Ophthalmology and Visual Science, 45(6), 1667 - 1673.
    • Lengyel I, Tufail A, Hosaini HA, Luthert P, Bird AC, Jeffery G (2004). Association of drusen deposition with choroidal intercapillary pillars in the aging human eye.. Investigative Ophthalmology and Visual Science, 45(9), 2886 - 2892. doi:10.1167/iovs.03-1083
    • Peirson SN, Bovee-Geurts PH, Lupi D, Jeffery G, DeGrip WJ, Foster RG (2004). Expression of the candidate circadian photopigment melanopsin (Opn4) in the mouse retinal pigment epithelium.. Molecular Brain Research, 123(1), 132 - 135.
    • Dawson WW, Jeffery G, Dawson JC, Kessler MJ, Rodriguez J, Westergaard GC (2004). Fundus pigment distribution in rhesus monkeys.. Veterinary Ophthalmology, 7(6), 391 - 396.
    • Tibber MS, Kralj-Hans I, Savage J, Mobbs PG, Jeffery G (2004). The orientation and dynamics of cell division within the plane of the developing vertebrate retina.. European Journal of Neuroscience, 19(3), 497 - 504.

    2003

    • Lavado A, Gimenez E, Giraldo P, Cozar P, Jeffery G, Montoliu L (2003). PP-22 A transgenic mouse model with inducible expression of the tyrosinase gene. Pigment Cell Research, 16(5), 600 - .
    • Neveu MM, Jeffery G, Burton LC, Sloper JJ, Holder GE (2003). Age-related changes in the dynamics of human albino visual pathways. European Journal of Neuroscience, 18(7), 1939 - 1949.
    • Semo M, Peirson S, Lupi D, Lucas RJ, Jeffery G, Foster RG (2003). Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) mice. European Journal of Neuroscience, 17(9), 1793 - 1801.
    • Tibber MS, Kralj-Hans I, Savage J, Mobbs PG, Jeffery G (2003). Planar polarity in developing mammalian and avian retina.
    • Kralj-Hans , Jeffery , G , Catsicas , Mobbs , P (2003). In vivo confocal imaging of mitosis in the ventricular zone of pigmented and albino rat retina.

    2002

    • Donatien P, Aigner B, Jeffery G (2002). Variations in cell density in the ganglion cell layer of the retina as a function of ocular pigmentation. European Journal of Neuroscience, 15(10), 1597 - 1602.
    • Cirone J, Sharp C, Jeffery G, Salt TE (2002). Distribution of metabotropic glutamate receptors in the superior colliculus of the adult rat, ferret and cat. Neuroscience, 109(4), 779 - 786.
    • Donatien P, Jeffery G (2002). Correlation between rod photoreceptor numbers and levels of ocular pigmentation. Investigative Ophthalmology and Visual Science, 43(4), 1198 - 1203.
    • Williams AL, Reese BE, Jeffery G (2002). Role of retinal afferents in regulating growth and shape of the lateral geniculate nucleus. The Journal of Comparative Neurology, 445(3), 269 - 277.

    2001

    • Gimenez E, Giraldo P, Jeffery G, Montoliu L (2001). Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene. Genesis, 30(1), 21 - 25.
    • Cayouette M, Whitmore A, Jeffery G, Raff MC (2001). Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium. Journal of Neuroscience, 21, 5643 - 5651.
    • Semo M, Bryce J, Jeffery G (2001). Oxygen modulates cell death in the proliferating retina. European Journal of Neuroscience, 13(6), 1257 - 1260.
    • Jeffery G (2001). Architecture of the optic chiasm and the mechanisms that sculpt its development. Physiological Reviews, 81(4), 1393 - 1414.
    • Grant S, Patel NN, Philp AR, Grey CN, Lucas RD, Foster RG, Bowmaker JK, Jeffery G (2001). Rod photopigment deficits in albinos are specific to mammals and arise during retinal development. Visual Neuroscience, 18(2), 245 - 251.
    • Williams AL, Jeffery G (2001). Growth dynamics of the developing lateral geniculate nucleus. The Journal of Comparative Neurology, 430(3), 332 - 342.

    2000

    • (2000). Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1. Human Molecular Genetics, 9(19), 2781 - 2788.
    • (2000). Retinal cell addition and rod production depend on early stages of ocular melanin synthesis. The Journal of Comparative Neurology, 420(4), 437 - 444.

    1999

    • (1999). Visual abnormalities in albino wallabies. The Journal of Comparative Neurology, 403, 33 - 38.
    • (1999). Retinal mitosis is regulated by dopa, a melanin precursor that may influence the time at which cells exit the cell cycle: analysis of patterns of cell production in pigmented and albino retinae. The Journal of Comparative Neurology, 405, 394 - 405.

    • Jeffery G, Kokkinopoulos I, Colman A, Hogg C, Heckenlively J, Jeffery G. (). Age related retinal inflammation is reduced by 670nm light via increased mitochondrial membrane potential. Neurobiology of Aging, , epub ahead of print - epub.
    • Jeffery G (). Development of Macular Disorders. British Journal of Ophthalmolgy, , epub ahead of print - epub.
    • Jeffery G (). Aged peripheral retinal lesions originating from the ciliary body sweep away the retinal pigmented epithelium.. British Journal of Ophthalmology, , epub ahead of print - epub.
    • Jeffery G (). Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function.. , , epub ahead of print - epub.
    • Jeffery G (). Glatiramer acetate elevates cell production in the mature retinal pigment epithelium.. Visual Neuroscience, , epub ahead of print - epub.
    • Jeffery G (). Arctic reindeer extend their visual range into the ultraviolet. The Journal of Experimental Biology, 214, 2014 - 2019.
    • Jeffery G (). Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss.. Plosone, 6(4), e18921 - .
    • Jeffery G (). Awareness and filling-in of the human blind spot: linking psychophysics with retinal topography. IOVS, , 541 - 548.
    • Jeffery G (). Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages.. Plosone, , e13127 - .
    • Jeffery G (). Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery. Molecular Vision, , 570 - 581.
    • Jeffery G (). The retinal pigment epithelium of the eye regulates the development of scleral cartilage. Developmental Biology, , 40 - 52.