Dr Eugene Schuster

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Personal Profile

Name: Eugene Schuster Email: e.schuster@ucl.ac.uk
Title: Dr Tel: 020 7679 2468
Department: Genetics, Evolution & Environment Fax: 020 7679 7096
Position: Senior Research Fellow Address: Darwin Building, Gower Street, London, WC1E 6BT
Research Domain: Populations & Lifelong Health Web Page:  

Profile

Research Description

Recent ageing studies have revealed a very surprising finding:  Ageing can be regulated.  Even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing.  Down regulation of the insulin/IGF-1 signaling (IIS) pathway can result in long-lived worms, flies, mice and possibly humans.  Mutations in insulin/insulin-like ligand receptors disrupt a downstream phosphorylation cascade resulting in the nuclear localization of a foxO forhead transcription factor, gene expression changes in hundreds to thousands of genes and long –lived animals.  Our main focus is to understand the mechanisms of foxO gene regulation in long-lived worms and to determine the extent of conversation of these mechanism across a wide range of species.

Research Activities

Cell signalling

Regulation of Ageing

Education Description

Lectures on Functional Genomic and System Biology in Ageing Research in "Biology of Ageing" BIOL3017

Tutorial on Gene Regulatory Networks in "Analysis of Biological Complexity"

UCL Collaborators

Prof Dame Linda Partridge; Prof David Gems; Dr Daniel Pearce; Prof Michael Duchen; Dr Babis Rallis; Dr Lazaros Foukas

External Collaborators

Publications

    2014

    • Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D (2014). DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans.. PLoS Genet, 10(2), e1004109 - . doi:10.1371/journal.pgen.1004109

    2013

    • Taiwo O, Wilson GA, Emmett W, Morris T, Bonnet D, Schuster E, Adejumo T, Beck S, Pearce DJ (2013). DNA methylation analysis of murine hematohematopoietic side population cells during aging.. Epigenetics, 8(10), - .
    • Harvey R, Schuster E, Jennings BH (2013). Pleiohomeotic Interacts with the Core Transcription Elongation Factor Spt5 to Regulate Gene Expression in Drosophila. PLoS One, 8(7), - . doi:10.1371/journal.pone.0070184
    • Cabreiro F, Au C, Vergara-Irigaray N, Cocheme HM, Noori T, Weinkove D, Schuster E, Greene NDE, Gems D (2013). Metformin retards aging in C.elegans by altering microbial folate and methionine metabolism. Cell, 153, 228 - 239. doi:10.1016/j.cell.2013.02.035

    2012

    • Derecka K, Blythe MJ, Malla S, Genereux DP, Guffanti A, Pavan P, Moles A, Snart C, Ryder T, Ortori CA, Barrett DA, Schuster EF, Stöger R (2012). Transient exposure to low levels of insecticide affects metabolic network of honeybee larvae. Proceedings of the National Academy of Sciences of the United States of America, submitted, - .
    • Gioti A, Wigby S, Wertheim B, Schuster E, Martinez P, Pennington CJ, Partridge L, Chapman T (2012). Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females. Proceedings of the Royal Society B: Biological Sciences, , - . doi:10.1098/rspb.2012.1634

    2011

    • Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, Hoddinott MP, Cocheme HM, Schuster EF, Thornton JM, Partridge L (2011). Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Molecular Systems Biology, 7, - . doi:10.1038/msb.2011.36

    2010

    • Schuster E, McElwee JJ, Tullet JMA, Doonan R, Matthijssens F, Reece-Hoyes JS, Hope IA, Vanfleteren JR, Thornton JM, Gems D (2010). DamID in C-elegans reveals longevity-associated targets of DAF-16/FoxO. MOL SYST BIOL, 6, - . doi:10.1038/msb.2010.54
    • Schuster E, McElwee JJ, Tullett JM, Doonan R, Matthijssens F, Reece-Hoyes JS, Vanfleteren JR, Thornton JM, Gems D (2010). DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO. Molecular Systems Biology, 6, 399 - .

    2009

    • Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ (2009). Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.. Science, 326(5949), 140 - 144. doi:10.1126/science.1177221

    2008

    • Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ (2008). Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. The FASEB Journal, 22(3), 807 - 818.

    2007

    • McElwee JJ, Schuster E, Blanc E, Piper MD, Thomas JH, Patel DS, Selman C, Withers DJ, Thornton JM, Partridge L, Gems DH (2007). Evolutionarily conservation of regulated longevity assurance mechanisms. Genome Biology, 8(7), R132 - . doi:10.1186/gb-2007-8-7-r132
    • Schuster EF, Blanc E, Partridge L, Thornton J (2007). Correcting for sequence biases in present/absent calls. GENOME BIOL, 8(6), - . doi:10.1186/gb-2007-8-6-r125
    • Schuster EF, Blanc E, Partridge L, Thornton J (2007). Estimation and correction of non-specific binding in a large-scale spike-in experiment. GENOME BIOL, 8(6), - . doi:10.1186/gb-2007-8-6-r126

    2006

    • Selman C, Kerrison ND, Cooray A, Piper MD, Lingard SJ, Barton RH, Schuster EF, Blanc E, Gems D, Nicholson JK, Thornton JM, Partridge L, Withers DJ (2006). Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiol Genomics, 27(3), 187 - 200.
    • McElwee JJ, Schuster E, Blanc E, Thornton J, Gems D (2006). Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans.. Mech Ageing Dev, 127(5), 458 - 472. doi:10.1016/j.mad.2006.01.006
    • McElwee JJ, Gems D, Schuster E, Blanc E, Thornton J (2006). Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472] (DOI:10.1016/j.mad.2006.01.006). Mechanisms of Ageing and Development, 127(12), 922 - 936. doi:10.1016/j.mad.2006.10.002

    2005

    • Choi JD, Underkoffler LA, Wood AJ, Collins JN, Williams PT, Golden JA, Schuster EF, Loomes KM, Oakey RJ (2005). A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island.. Mol Cell Biol, 25(13), 5514 - 5522. doi:10.1128/MCB.25.13.5514-5522.2005
    • Wertheim B, Kraaijeveld AR, Schuster E, Blanc E, Hopkins M, Pletcher SD, Strand MR, Partridge L, Godfray HC (2005). Genome-wide gene expression in response to parasitoid attack in Drosophila.. Genome Biol, 6(11), R94 - . doi:10.1186/gb-2005-6-11-r94

    2004

    • McElwee JJ, Schuster E, Blanc E, Thomas JH, Gems D (2004). Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance.. J Biol Chem, 279(43), 44533 - 44543. doi:10.1074/jbc.M406207200

    2002

    • Schuster EF, Stoger R (2002). CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases. , 13, 117 - 119.

    2001

    • Peters MA, Jarvik GP, Janer M, Chakrabarti L, Kolb S, Goode EL, Gibbs M, DuBois CC, Schuster EF, Hood L, Ostrander EA, Stanford JL (2001). Genetic linkage analysis of prostate cancer families to Xq27-28. , 51, 107 - 113.

    2000

    • Goode EL, Stanford JL, Chakrabarti L, Gibbs M, Kolb S, McIndoe RA, Buckley VA, Schuster EF, Neal CL, Miller EL, Brandzel S, Hood L, Ostrander EA, Jarvik GP (2000). Linkage analysis of 150 high-risk prostate cancer families at 1q24-25. , 18, 251 - 275.

    1999

    • Gibbs M, Chakrabarti L, Stanford JL, Goode EL, Kolb S, Schuster EF, Buckley VA, Shook M, Hood L, Jarvik GP, Ostrander EA (1999). Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer. , 64, 1087 - 1095.
    • Gibbs M, Stanford JL, McIndoe RA, Jarvik GP, Kolb S, Goode EL, Chakrabarti L, Schuster EF, Buckley VA, Miller EL, Brandzel S, Li S, Hood L, Ostrander EA (1999). Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. , 64, 776 - 787.

    1996

    • Aldaz H, Schuster E, Baker TA (1996). The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis.. Cell, 85(2), 257 - 269.

    1995

    • BAKER TA, KREMENTSOVA E, SCHUSTER E, LUO L (1995). COMPLETE TRANSPOSITION REQUIRES 4 ACTIVE MONOMERS IN THE MU-TRANSPOSASE TETRAMER. J CELL BIOCHEM, , 98 - 98.