Prof Donald Peebles

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Personal Profile

Name: Donald Peebles Email: d.peebles@ucl.ac.uk
Title: Prof Tel: 020 7679 6051
Department: Maternal & Fetal Medicine Fax: 020 3108 2036
Position: Chair of Obstetrics Address: Medical School Building, 74 Huntley Street, London, WC1E 6AU
Research Domain: Basic Life Sciences, Infection, Immunology & Inflammation, Neuroscience, Personalised Medicine, Populations & Lifelong Health, Reproduction & Development Web Page: Personal Web Page

Profile

Research Description

For the past 5 years I have been the UCL Chair of Maternal Fetal Medicine leading a Department of 20 clinicians and scientists. Current research includes studies of 1) maternal innate immunity, infection, inflammation and preterm labour 2) the role of hypoxia and inflammation in causation of perinatal brain injury 3) fetal physiology (especially fetal responses to acute and chronic substrate deprivation) and 4) the development of novel molecular and cellular methods for treatment of fetal disease. Current projects include a first in human study of maternal gene therapy to treat severe intrauterine fetal growth restriction; a case control study to define the interaction between the maternal vaginal/cervical microbiome and cervical innate immunity in the aetiology of preterm labour and preclinical studies to define novel therapies for fetal brain injury.


Research Activities

Cardiovascular Biology and Medicine

Gene transfer technology

Genetic aetiology of intrauterine growth restriction

Investigation and prevention of perinatally acquired brain injury

Perinatal Neuroscience

Perinatal Neuroscience

pediatric sepsis

Education Description

My current teaching related activities include:

Lead for Clinical Academic Training Programme in Womens Health, UCL: currently 3 CLs, 3 ACFs.

Academic representative on the UCLP TRainining Programme Management Committee for Obstetrics and Gynaecology (2008 - ) I am an active member of the TPMC and was extensively involved in the preparation of the successful bid by UCLPartners to become the Lead provider of postgraduate training for NCl and NE London in 2011.

Module Lead IfWH MSc Pregnancy and Childbirth

Member Institute of Women’s Health Undergraduate Committee

Member Institute of Women’s Health Postgraduate Committee 

I supervise 2 PhD students

Supervise and teach 3 RCOG recognised subspecialty trainees in Materno-Fetal Medicine

I am an Academic Mentor

Undergraduate teaching/mentorship 2 hours/week

UCL Collaborators

Prof Gennadij Raivich; Prof Gudrun Moore; Prof Nikki Robertson; Prof Nigel Klein; Dr Anna David; Prof Sebastian Brandner; Prof John Martin; Prof Ian Zachary; Prof Kristjan Jessen; Prof Rhona Mirsky; Dr Ian Evans; Miss Eridan Rocha Ferreira; Dr Anthony Mathur; Prof Robin Callard; Prof Deenan Pillay; Dr Mona Bajaj-Elliot; Dr Mariya Hristova

External Collaborators

Publications

    2014

    • Addison S, Munroe P, Mein C, Cohen M, Fowler D, Sebire NJ, Peebles D, Taylor A, Abrams D, Thayyil S (2014). 8.2 cardiac ion channelopathies in unexplained stillbirths.. Arch Dis Child Fetal Neonatal Ed, 99 Suppl 1, A11 - . doi:10.1136/archdischild-2014-306576.31
    • James CP, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles DM (2014). Systemic Innate Immune Response in the First Trimester Is Related to DEFB1 Genotype, and Is Distinct in Women Who Develop PPROM and Deliver before 34 Weeks of Gestation. REPRODUCTIVE SCIENCES, 21(3), 239A - 239A.
    • Lange S, Rocha Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M, Raivich G (2014). Peptidylarginine Deiminases (PADs) - Novel Drug Targets for Prevention of Neuronal Damage following Hypoxic Ischemic Insult (HI) in Neonates.. J Neurochem, , - . doi:10.1111/jnc.12744
    • Carr D, Wallace JM, Aitken RP, Milne JS, Mehta V, Martin JF, Zachary IC, Peebles D, David AL (2014). Uteroplacental adenovirus VEGF gene therapy increases fetal growth velocity in growth-restricted sheep pregnancies.. Hum Gene Ther, , - . doi:10.1089/hum.2013.214
    • Demetriou C, Abu-Amero S, Thomas AC, Ishida M, Aggarwal R, Al-Olabi L, Leon LJ, Stafford JL, Syngelaki A, Peebles D, Nicolaides KH, Regan L, Stanier P, Moore GE (2014). Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight.. PLoS One, 9(1), e85454 - . doi:10.1371/journal.pone.0085454
    • James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2014). 8.4 Serum beta defensin concentration in the first trimester is related to genotype, and is higher in women who develop PPROM and deliver before 34 weeks.. Arch Dis Child Fetal Neonatal Ed, 99 Suppl 1, A12 - . doi:10.1136/archdischild-2014-306576.33
    • Castanon A, Landy R, Brocklehurst P, Evans H, Peebles D, Singh N, Walker P, Patnick J, Sasieni P (2014). PPO.60 Risk of preterm delivery with increasing depth of excision for cervical intraepithelial neoplasia in England: nested case-control study.. Arch Dis Child Fetal Neonatal Ed, 99 Suppl 1, A169 - A170. doi:10.1136/archdischild-2014-306576.499
    • James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2014). Systemic innate immune response in the first trimester is related to DEFB1 genotype, and is distinct in women who develop PPROM and deliver before 34 weeks of gestation. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 121(7), E11 - E11.
    • Migale R, MacIntyre DA, Lee YS, Charalambous A, Herbert BR, Waddington SN, Peebles D, Hagberg H, Johnson MR, Bennett PR (2014). TLR4-mediated activation of AP-1 drives the expression of labour associated genes in mouse myometrium. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 121(7), E10 - E10.
    • MacIntyre DA, Lee YS, Migale R, Herbert BR, Waddington SN, Peebles D, Hagberg H, Johnson MR, Bennett PR (2014). Activator protein 1 is a key terminal mediator of inflammation-induced preterm labor in mice. FASEB JOURNAL, 28(5), 2358 - 2368. doi:10.1096/fj.13-247783
    • Swanson AM, Ofir K, Glazewska AA, Scott SJ, Mehta V, Boyde M, Barker H, Martin J, Zachary I, Peebles DM, David AL (2014). Locally Administered Uterine Artery Ad.VEGF(165) Gene Therapy in Growth Restricted Guinea Pig Pregnancy. REPRODUCTIVE SCIENCES, 21(3), 374A - 375A.
    • Rocha-Ferreira E, Thei L, Peebles D, Behrens A, Akira S, Raivich G, Hristova M (2014). Signal Transduction and Activation of Transcription Factor 3 (STAT3) Mediates Neonate Hypoxic Ischaemic Brain Injury. REPRODUCTIVE SCIENCES, 21(3), 372A - 372A.
    • Rocha-Ferreira E, Francesch-Domenech E, Thei L, Rahim A, Lange S, Peebles D, Hristova M, Raivich G (2014). The Role of Infection and the TNF Family of Cytokines in Neonatal Hypoxic-Ischemic Brain Injury.. REPRODUCTIVE SCIENCES, 21(3), 108A - 109A.
    • Migale R, MacIntyre DA, Lee YS, Charalambous A, Herbert BR, Waddington SN, Peebles D, Hagberg H, Johnson MR, Bennett PR (2014). TLR4-Mediated Activation of AP-1 Drives the Expression of Labour Associated Genes in Mouse Myometrium. REPRODUCTIVE SCIENCES, 21(3), 249A - 249A.
    • Mehta V, Abi-Nader KN, Shangaris P, Shaw SW, Filippi E, Benjamin E, Boyd M, Peebles DM, Martin J, Zachary I, David AL (2014). Local Over-Expression of VEGF-DΔNΔC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis.. PLoS One, 9(6), e100021 - . doi:10.1371/journal.pone.0100021

    2013

    • Demetriou C, Abu-Amero S, Thomas AC, Ishida M, Aggarwal R, Al-Olabi L, Leon LJ, Stafford JL, Syngelaki A, Peebles D, Nicolaides KH, Regan L, Stanier P, Moore GE (2013). Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight.
    • Carr DJ, Aitken RP, Milne JS, Peebles DM, Martin JF, Zachary IC, Wallace JM, David AL (2013). DNA Methylation of Somatotropic Axis Genes in Relation to Postnatal Growth and Metabolism Following Ad. VEGF Treatment of Growth-Restricted Sheep Fetuses.
    • James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2013). Association of human beta defensin-1 (DEFB1) polymorphisms and in vivo protein expression: first population-based analysis.
    • Hillman S, Peebles DM, Williams DJ (2013). Paternal metabolic and cardiovascular risk factors for fetal growth restriction: a case-control study.. Diabetes Care, 36(6), 1675 - 1680. doi:10.2337/dc12-1280
    • James CP, Klein N, Bajaj-Elliott M, Peebles D (2013). Progesterone Modulates Cervical Antimicrobial Immunity..
    • Carr DJ, Aitken RP, Milne JS, Mehta V, Peebles DM, Martin JF, Zachary IC, Wallace JM, David AL (2013). Prenatal adenovirus vascular endothelial growth factor gene therapy: a promising new treatment for fetal growth restriction.
    • Carr DJ, Aitken RP, Milne JS, Peebles DM, Martin JF, Zachary IC, Wallace JM, David AL (2013). DNA methylation of somatropic axis genes in relation to postnatal growth and metabolism following Ad.VEGF treatment of growth-restricted sheep fetuses.
    • James CP, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2013). Variation in Beta Defensin 1 Genotype Is Associated with Preterm Birth..
    • Castanon A, Brocklehurst P, Peebles D, Evans H, Singh N, Landy R, Walker P, Patnick J, Sasieni P (2013). Risk of preterm delivery after treatment for cervical intraepithelial neoplasia in England, United Kingdom. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 120, 229 - 229.

    2012

    • Hillman S, Whitten M, Peebles D, Williams D (2012). An Insulin Resistant Phenotype in Men Who Father Pregnancies Affected by Fetal Growth Restriction.. REPRODUCTIVE SCIENCES, 19(S3), 151A - 151A.
    • Azizia M, Lloyd J, Allen M, Klein N, Peebles D (2012). Immune status in very preterm neonates.. Pediatrics, 129(4), e967 - e974. doi:10.1542/peds.2011-1579
    • Mehta V, Peebles D, David AL (2012). Animal models for prenatal gene therapy: choosing the right model.. Methods Mol Biol, 891, 183 - 200. doi:10.1007/978-1-61779-873-3_9
    • Mehta V, Abi-Nader KN, Carr D, Wallace J, Coutelle C, Waddington SN, Peebles D, David AL (2012). Monitoring for potential adverse effects of prenatal gene therapy: use of large animal models with relevance to human application.. In (Ed.), (pp. 291 - 328). : . doi:10.1007/978-1-61779-873-3_14
    • Peebles D (2012). Radical change for the fetus. JOURNAL OF PHYSIOLOGY-LONDON, 590(8), 1773 - 1773. doi:10.1113/jphysiol.2012.231217
    • Kendall G, Hristova M, Zbarsky V, Clements A, Peebles DM, Robertson NJ, Raivich G (2012). Distribution of pH changes in mouse neonatal hypoxic ischemic insult. Dev Neurosci, in press, - .
    • Mehta V, Abi-Nader KN, Peebles DM, Benjamin E, Wigley V, Torondel B, Filippi E, Shaw SW, Boyd M, Martin J, Zachary I, David AL (2012). Long-term increase in uterine blood flow is achieved by local overexpression of VEGF-A(165) in the uterine arteries of pregnant sheep.. Gene Ther, 19(9), 925 - 935. doi:10.1038/gt.2011.158
    • Mehta V, Boyd M, Barker H, Avdic-Belltheus A, Carr D, Martin J, Zachary I, Peebles D, David AL (2012). Local Administration of Ad.VEGF-A(165) to the Utero-Placental Circulation Enhances Fetal Growth and Reduces Brain Sparing in an FGR Model of Guinea Pig Pregnancy. REPRODUCTIVE SCIENCES, 19(S3), 78A - 78A.
    • Peebles D, Castanon A, Brocklehurst P, Evans H, Singh N, Walker P, Patnick J, Sasieni PD (2012). Risk of Preterm Delivery after Treatment for Cervical Intraepithelial Neoplasia. REPRODUCTIVE SCIENCES, 19(S3), 300A - 300A.
    • Albar D, Alviani C, Harris K, Klein N, Peebles D (2012). Bacteria Identified by PCR in Fetal Membranes Following Preterm Labour Associated with Increased Toll Receptor Expression. REPRODUCTIVE SCIENCES, 19(S3), 121A - 121A.
    • Carr DJ, Aitken RP, Milne JS, Peebles DM, Martin JF, Zachary IC, Wallace JM, David AL (2012). Prenatal Ad.VEGF Gene Therapy Increases Fetal Growth Velocity and Expression of VEGF Receptors in an Ovine Paradigm of Fetal Growth Restriction. REPRODUCTIVE SCIENCES, 19(S3), 78A - 78A.
    • Castanon A, Sasieni P, Brocklehurst P, Peebles D, Evans H, Walker P, Singh N, Patnick J (2012). Risk of preterm birth after treatment for cervical intraepithelial neoplasia among women attending colposcopy in England: Retrospective-prospective cohort study. BMJ (Online), 345(7874), - . doi:10.1136/bmj.e5174
    • Addison S, Sebire NJ, Taylor AM, Abrams D, Peebles D, Mein C, Munroe PB, Thayyil S (2012). High quality genomic DNA extraction from postmortem fetal tissue.. J Matern Fetal Neonatal Med, 25(11), 2467 - 2469. doi:10.3109/14767058.2012.704442
    • Schuler PK, Herrey A, Wade A, Brooks R, Peebles D, Lambiase P, Walker F (2012). Pregnancy outcome and management of women with an implantable cardioverter defibrillator: a single centre experience.. Europace, 14(12), 1740 - 1745. doi:10.1093/europace/eus172
    • Abi-Nader KN, Boyd M, Flake AW, Mehta V, Peebles D, David AL (2012). Animal models for prenatal gene therapy: the sheep model.. Methods Mol Biol, 891, 219 - 248. doi:10.1007/978-1-61779-873-3_11

    2011

    • Carr DJ, Aitken RP, Milne JS, Peebles DM, Martin JF, Zachary IC, Wallace JM, David AL (2011). Prenatal Ad.VEGF gene therapy - a promising new treatment for fetal growth restriction.
    • Kenyon AP, Peebles D (2011). Myth: tocolysis for prevention of preterm birth has a major role in modern obstetrics.. Semin Fetal Neonatal Med, 16(5), 242 - 246. doi:10.1016/j.siny.2011.04.008
    • Mehta V, Peebles DM, Boyd M, Zachary IC, Martin JF, David AL (2011). Gene Targeting to the Utero-Placental Circulation of Pregnant Guinea Pigs.
    • Carr DJ, Aitken RP, Milne JS, Peebles DM, Martin JF, Zachary IC, Wallace JM, David AL (2011). Maternal Delivery of Ad.VEGF GeneTherapy Increases Fetal Growth Velocity in an Ovine Paradigm of Fetal Growth Restriction.
    • Filippi E, Staughton J, Peregrine E, Jones P, Huttly W, Peebles DM, Pandya P , David AL (2011). Uterine artery Doppler and adverse pregnancy outcome in women with extreme levels of feto-placental proteins used for Down’s syndrome screening.. Ultrasound in Obstetrics and Gynecology, , - .
    • David AL, McIntosh J, Peebles DM, Cook T, Waddington S, Weisz B, Wigley V, Abi-Nader K, Boyd M, Davidoff AM, Nathwani AC (2011). Recombinant adeno-associated virus-mediated in utero gene transfer gives therapeutic transgene expression in the sheep.. Hum Gene Ther, 22(4), 419 - 426. doi:10.1089/hum.2010.007
    • Kendall GS, Hristova M, Horn S, Dafou D, Acosta-Saltos A, Almolda B, Zbarsky V, Rumajogee P, Heuer H, Castellano B, Pfeffer K, Nedospasov SA, Peebles DM, Raivich G (2011). TNF gene cluster deletion abolishes lipopolysaccharide-mediated sensitization of the neonatal brain to hypoxic ischemic insult.. Lab Invest, 91(3), 328 - 341. doi:10.1038/labinvest.2010.192
    • Abi-Nader KN, Mehta V, Shaw SW, Bellamy T, Smith N, Millross L, Laverick B, Filippi E, Boyd M, Peebles DM, David AL (2011). Telemetric monitoring of fetal blood pressure and heart rate in the freely moving pregnant sheep: a feasibility study.. Lab Anim, 45(1), 50 - 54. doi:10.1258/la.2010.010059
    • Addison S, Sebire NJ, Judge-Kronis L, Taylor AM, Abrams D, Scott R, Robertson NJ, Peebles D, Mein C, Munroe PB, Thayyil S (2011). GENOMIC DEOXYRIBONUCLEIC ACID EXTRACTION FROM POST MORTEM FETAL TISSUE. PEDIATRIC RESEARCH, 70, 406 - 406. doi:10.1038/pr.2011.631
    • Rahim AA, Buckley SMK, Peebles DM, Waddington SN, Chan JKY (2011). Perinatal gene delivery to the CNS. Therapeutic Delivery, 2(4), 483 - 491. doi:10.4155/tde.11.16
    • Buckley SMK, Rahim AA, David AL, Peebles DM, Waddington SN, Chan JKY, Coutelle C (2011). Recent advances in fetal gene therapy. Therapeutic Delivery, 2(4), 461 - 469. doi:10.4155/tde.11.17
    • Kendall GS, Hristova M, Zbarsky V, Clements A, Peebles DM, Robertson NJ, Raivich G (2011). Distribution of pH changes in mouse neonatal hypoxic-ischaemic insult.. Dev Neurosci, 33(6), 505 - 518. doi:10.1159/000333850
    • Mattar CN, Nathwani AC, Waddington SN, Dighe N, Kaeppel C, Nowrouzi A, McIntosh J, Johana NB, Ogden B, Fisk NM, Davidoff AM, David A, Peebles D, Valentine MB, Appelt JU, von KC, Schmidt M, Biswas A, Choolani M, Chan JK (2011). Stable Human FIX Expression After 0.9G Intrauterine Gene Transfer of Self-complementary Adeno-associated Viral Vector 5 and 8 in Macaques. Mol.Ther., 19(11), 1950 - 1960. doi:10.1038/mt.2011.107
    • Carr DJ, Aitken RP, Milne JS, Peebles DM, Martin J, Zachary I, David AL, Wallace JM (2011). Alterations in postnatal growth and metabolism following prenatal treatment of intrauterine growth restriction with Ad.VEGF gene therapy in the sheep.
    • Mehta V, Abi-Nader KN, Shangaris P, Shaw SWS, Boyd M, Zachary IC, Martin JF, Peebles DM, David AL (2011). The Effects of Local Over-Expression of VEGF-D on the Uterine Arteries and Uterine Artery Endothelial Cells of Pregnant Sheep.
    • Carr DJ, Aitken RP, Milne JS, Peebles DM, Martin J, Zachary I, Wallace JM, David AL (2011). Maternal Ad.VEGF gene therapy increases fetal growth in growth-restricted sheep fetuses.

    2010

    • Mehta V, Abi-Nader K, Buitendyk M, Boyd M, Zachary IC, Martin JF, Peebles DM, David AL (2010). The effects of local over-expression of VEGF on uterine arteries and uterine artery endothelial cells of pregnant sheep.
    • Abi-Nader KN, Mehta V, Wigley V, Filippi E, Tezcan B, Boyd M, Peebles DM, David AL (2010). Doppler ultrasonography for the noninvasive measurement of uterine artery volume blood flow through gestation in the pregnant sheep.. Reprod Sci, 17(1), 13 - 19. doi:10.1177/1933719109344772
    • Mattar CN, Nathwani AC, Dighe N, Waddington S, McIntosh J, Biswas A, Fisk N, Davidoff AM, David A, Peebles D, Nowrouzi A, Kappel C, Schmidt M, Choolani M, Chan J (2010). Late-Gestation Intravascular Delivery of Self-Complementary AAV Leads to Sustained Transgene Expression with the Possibility of Vector Integration Events in the Liver.
    • Hristova M, Cuthill D, Zbarsky V, Acosta-Saltos A, Wallace A, Blight K, Buckley SM, Peebles D, Heuer H, Waddington SN, Raivich G (2010). Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development.. Glia, 58(1), 11 - 28. doi:10.1002/glia.20896
    • Greutmann M, Von Klemperer K, Brooks R, Peebles D, O'Brien P, Walker F (2010). Pregnancy outcome in women with congenital heart disease and residual haemodynamic lesions of the right ventricular outflow tract.. Eur Heart J, 31(14), 1764 - 1770. doi:10.1093/eurheartj/ehq157
    • Mehta V, Abi-Nader K, Buitendyk M, Shaw SWS, Boyd M, Zachary IC, Martin JF, Peebles DM, David AL (2010). The Effects of Local Over-Expression of VEGF on the Uterine Arteries and Uterine Artery Endothelial Cells of Pregnant Sheep.
    • David AL, Abi-Nader KN, Weisz B, Shaw SW, Themis M, Cook T, Coutelle C, Rodeck CH, Peebles DM (2010). Ultrasonographic development of the fetal sheep stomach and evaluation of early gestation ultrasound-guided in utero intragastric injection.. Taiwan J Obstet Gynecol, 49(1), 23 - 29. doi:10.1016/S1028-4559(10)60004-6
    • Filippi E, Staughton J, Peregrine E, Jones P, Huttly W, Peebles D, Pandya P, David A (2010). Uterine artery Doppler and adverse pregnancy outcome in women with extreme levels of feto-placental proteins used for Down's syndrome screening.. Ultrasound Obstet Gynecol, , - . doi:10.1002/uog.8901
    • Rahim AA, Wong AM, Buckley SM, Chan JK, David AL, Cooper JD, Coutelle C, Peebles DM, Waddington SN (2010). In utero gene transfer to the mouse nervous system.. Biochem Soc Trans, 38(6), 1489 - 1493. doi:10.1042/BST0381489

    2009

    • Acosta-Saltos A, Hristova M, Zbarsky V, Acosta-Saltos F, Peebles D, Behrens A, Raivich G (2009). Role of c-Jun in Neonatal Hypoxic-Ischemic Brain Injury.
    • Jones HE, Azizia M, Harris KA, Hartley JC, Klein N, Peebles D (2009). The Role of Infection in Preterm Labour: Broad-Range 16S rDNA PCR Identifies a Variety of Bacterial Candidates.
    • Jones HE, Harris KA, Azizia M, Bank L, Carpenter B, Hartley JC, Klein N, Peebles D (2009). Differing prevalence and diversity of bacterial species in fetal membranes from very preterm and term labor.. PLoS One, 4(12), e8205 - . doi:10.1371/journal.pone.0008205
    • Mehta V, Abi-Nader K, Torondel B, Wigley V, Tezcan B, Fillipi E, Petts G, Boyd M, Rodeck C, Zachary I, Martin J, Peebles D, David A (2009). Long-term changes in uterine blood flow and vascular reactivity in pregnant sheep following local delivery of an adenovirus encoding VEGF to the uterine arteries. BJOG-INT J OBSTET GY, 116(10), 1411 - 1412.
    • Lagercrantz H, Hanson MA, Ment LR, peebles D (2009). The Newborn Brain.
    • Abi Nader KN, Mehta V, Torondel B, Wigley V, Zachary I, Martin J, Boyd M, Tezcan B, Filippi E, Petts G, Rodeck C, Peebles D, David AL (2009). The effect of local over-expression of VEGF on the uterine arteries of pregnant sheep long term.
    • Hristova M, Cuthill D, Zbarsky V, Acosta-Saltos A, Wallace A, Acosta-Saltos F, Blight K, Peebles D, Waddington S, Raivich G (2009). Periventricular Fountains of Microglia and the Down-Regulation of Microglial Activation (luring Postnatal Mouse Development.
    • Quinn J, Von Klemperer K, Brooks R, Peebles D, Walker F, Cohen H (2009). Use of high intensity adjusted dose low molecular weight heparin in women with mechanical heart valves during pregnancy: a single-center experience.. Haematologica, 94(11), 1608 - 1612. doi:10.3324/haematol.2008.002840

    2008

    • Quinn J, Brooks R, Peebles D, Walker F, Cohen H (2008). Dose-escalated low molecular weight heparin provides effective anticoagulation for women with mechanical heart valves during pregnancy: a single-centre experience.
    • David AL, Peebles D (2008). Gene therapy for the fetus: is there a future?. BEST PRACT RES CL OB, 22(1), 203 - 218. doi:10.1016/i.bpobgyn.2007.08.008
    • Weisz B, David AL, Chitty L, Peebles D, Pandya P, Patel P, Rodeck CH (2008). Association of isolated short femur in the mid-trimester fetus with perinatal outcome.. Ultrasound Obstet Gynecol, 31(5), 512 - 516. doi:10.1002/uog.5349
    • Lambert JR, Austin SK, Peebles D, Cohen H (2008). Audit of the peri-delivery use of unfractionated heparin in women on therapeutic low-molecular weight heparin.. Br J Haematol, 142(3), 453 - 456. doi:10.1111/j.1365-2141.2008.07198.x
    • David AL, McIntosh J, Weisz B, Boyd M, Cook T, Wigley V, Kymalainen H, Abi-Nader K, Rodeck CH, Peebles DM, Nathwani A (2008). Long term perinatal gene transfer after clinically applicable delivery of prenatal gene therapy in the sheep.
    • Weisz B, David AL, Chitty L, Peebles D, Pandya P, Patel P, Rodeck CH (2008). The association of midtrimester short femur with perinatal outcome. Ultrasound in Obstetrics and Gynecology, 31(5), 512 - 516.
    • Hristova M, Zbarsky V, Cuthill D, Wallace A, Peebles D, Raivich G (2008). Regulation of microglial activation in the developing murine brain..
    • Hristova M, Zbarsky V, Kendall G, Makwana M, Miller F, Kaplan D, Raivich G, Peebles D (2008). The role of mitogen kinase kinase (MEK) and its inhibition in perinatal brain injury.
    • Wang X, Carmichael DW, Cady EB, Gearing O, Bainbridge A, Ordidge RJ, Raivich G, Peebles DM (2008). Greater hypoxia-induced cell death in prenatal brain after bacterial-endotoxin pretreatment is not because of enhanced cerebral energy depletion: a chicken embryo model of the intrapartum response to hypoxia and infection.. Journal of Cerebral Blood Flow and Metabolism, 28(5), 948 - 960. doi:10.1038/sj.jcbfm.9600586
    • David AL, Torondel B, Wigley V, Abi-Nader K, Zachary I, Martin J, Boyd M, Cook T, Rodeck C, Peebles D (2008). Long-term increases in vasorelaxation and blood flow to the pregnant sheep uterus following local delivery of adenovirus VEGF to uterine arteries..
    • David AL, Torondel B, Zachary I, Wigley V, Abi Nader K, Mehta V, Buckley SMK, Cook T, Boyd M, Rodeck CH, Martin J, Peebles DM (2008). Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep.. Gene Therapy, 15, 1344 - 1350.
    • David AL, Peebles D (2008). Gene therapy for the fetus: is there a future?. Best Pract Res Clin Obstet Gynaecol, 22(1), 203 - 218. doi:10.1016/j.bpobgyn.2007.08.008
    • David AL, McIntosh J, Nathwani A, Cook T, Boyd M, Weisz B, Wigley V, Abi Nader K, Rodeck CH, Peebles DM (2008). Long-term expression of human factor IX after ultrasound-guided delivery of AAV8 hFIX to fetal sheep in utero.
    • Peebles D (2008). Antibiotic use and women in preterm labour. BRIT J HOSP MED, 69(11), 610 - 611.
    • David AL, McIntosh J, Nathwani A, Cook T, Boyd M, Weisz B, Wigley V, Abi-Nader K, Rodeck C, Peebles D (2008). Long term expression of human factor IX after ultrasound-guided fetal gene therapy in sheep.

    2007

    • Farrugia MK, Woolf AS, Fry CH, Peebles DM, Cuckow PM, Godley ML (2007). Radiotelemetered urodynamics of obstructed ovine fetal bladders: correlations with ex vivo cystometry and renal histopathology. BJU International, 99(6), 1517 - 1522. doi:10.1111/j.1464-410X.2007.06799.x
    • Waddington SN, Buckley SM, David AL, Peebles DM, Rodeck CH, Coutelle C (2007). Fetal gene transfer. Curr Opin Mol Ther, 9, 432 - 438.
    • David AL, Peregrine E, Jones P, Huttly W, Peebles DM, Pandya P, Rodeck CH (2007). Uterine artery Doppler in women with abnormal first and second trimester serum screening. doi:10.1002/uog.4547
    • David AL, Torondel B, Zachary I, Ramirez MJ, Buckley SM, Cook T, Boyd M, Rodeck CH, Martin J, Peebles D (2007). Local delivery of adenovirus VEGF to the uterine arteries increases vessel relaxation and uterine artery blood flow in the sheep.
    • Hristova M, Zbarskyl V, Kendall G, Makwana M, Peebles D, Miller FD, Kaplan DR, Raivich G (2007). Neuronal MEK in brain damage and perinatal brain injury. NEURON GLIA BIOL, 2, S158 - S159.
    • Raivich G, Kendall G, Hristova M, Peebles DM, Nedospasov SA, Pfeffer K (2007). Inflammation and the neurodegenerative process in perinatal brain damage.
    • Quinn J, Brooks R, Walker F, Peebles D, Cohen H (2007). Dose-escalated low molecular weight heparin provides effective anticoagulation for women with mechanical heart valves during pregnancy: A single-centre experience.
    • Iwata O, Iwata S, Thornton JS, De Vita E, Bainbridge A, Herbert L, Scaravilli F, Peebles D, Wyatt JS, Cady EB, Robertson NJ (2007). "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets.. Brain Research, 1154, 173 - 180. doi:10.1016/j.brainres.2007.03.083
    • Weisz B, David AL, Chitty D, Peebles DM, Pandya P, Rodeck CH (2007). The association of isolated mid-trimester short femur with perinatal outcome.. doi:10.1002/uog.4143
    • Peregrine E, Peebles DM (2007). Fetal growth and growth restriction. In Rodeck CH, Whittle M (Ed.), Fetal Medicine: Basic Science and Clinical Practice (pp. - ). : Churchill Livingstone.
    • Lloyd J, Allen M, Azizia M, Klein N, Peebles D (2007). Monocyte major histocompatibility complex class II expression in term and preterm labor. OBSTET GYNECOL, 110(6), 1335 - 1342.
    • Lambert J, Austin S, Peebles D, Cohen H (2007). Managing peri-delivery anticoagulation in women on therapeutic dose low-molecular weight heparin: a role for unfractionated heparin.
    • Austin SK, Nash ML, Peebles D, Cohen H (2007). Successful management of late obstetric complications in the antiphospholipid syndrome.
    • Hristova M, Zbarsky V, Cuthill D, Wallace A, Peebles D, Raivich G (2007). Regulation of microglial activation during postnatal mouse development. NEURON GLIA BIOL, 2, S47 - S47.
    • Lloyd J, Aziza M, Allen M, Klein N, Peebles D (2007). Correlation between MHC class II expression on cord blood monocytes and outcome in term and preterm neonates. BJOG-INT J OBSTET GY, 114(8), 1035 - 1035.

    2006

    • Lloyd J, Riley K, Wyatt J, Peebles D (2006). The influence of birthweight for gestational age on neurodevelopmental outcome at 1 year of age in premature infants weighing < 1000 g. EARLY HUM DEV, 82(9), 616 - 617.
    • Wang XL, Raivich G, Peebles DM (2006). Effect of mild hyperthermia on hypoxia induced neural cell death in chick embryos in ovo..
    • Weisz B, David A, Chitty L, Peebles D, Pandya P, Rodeck C (2006). The association of midtrimester short femur with perinatal outcome. doi:10.1016/j.ajog.2006.10.251
    • Lloyd J, Allen ML, Klein NJ, Peebles DM (2006). Correlation between MHC class II expression on cord blood monocytes and outcome in term and preterm neonates..
    • David A, Weisz B, Ruthe A, Peebles DM, Coutelle C, Rodeck CH, Themis M (2006). Gene transfer to human fetal tissues in vitro. BJOG-INT J OBSTET GY, 113(7), 863 - 863.
    • Farrugia MK, Godley ML, Woolf AS, Peebles DM, Cuckow PM, Fry CH (2006). Experimental short-term partial fetal bladder outflow obstruction: II. Compliance and contractility associated with urinary flow impairment. Journal of Pediatric Urology, 2(4), 254 - 260.
    • Farrugia MK, Long DA, Godley ML, Peebles DM, Fry CH, Cuckow PM, Woolf AS (2006). Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment. Journal of Pediatric Urology, 2(4), 243 - 253.
    • Iwata S, Iwata O, Thornton JS, Shanmugalingam S, Bainbridge A, Peebles D, Wyatt JS, Cady EB, Robertson NJ (2006). Superficial brain is cooler in small piglets: neonatal hypothermia implications.. Annals of Neurology, 60(5), 578 - 585. doi:10.1002/ana.20978
    • Peebles D (2006). Animal models of fetal growth restriction and cerebral compromise. In Baker P, Sibley C (Ed.), The placenta and neurodisability. (pp. - ). : Mac Keith Press.
    • Rennie J, Peebles D (2006). Pestivirus as a cause of white matter damage - down but not out. Dev Med Child Neurol, 48, 243 - . doi:10.1017/S0012162206000533
    • Rodeck CH, Weisz B, Peebles DM, Jauniaux E (2006). Hypothesis: The Placental 'Steal' Phenomenon - A Possible Hazard of Amnioreduction.. Fetal Diagnosis and Therapy, 21(3), 302 - 306.
    • David AL, Weisz B, Gregory L, Themis M, Cook T, Roubliova X, Deprest J, Coutelle C, Rodeck CH, Peebles DM (2006). Ultrasound guided injection and occlusion of the trachea in fetal sheep.. Ultrasound in Obstetrics and Gynecology, 28(1), 82 - 88.
    • Kendall G, Clements A, Varley H, Peebles D, Raivich G (2006). The sensitising effects of inflammation on hypoxic-ischaemic brain injury. EARLY HUM DEV, 82(9), 615 - 616.
    • Kendall G, Varley H, Peebles DM, Raivich G (2006). Time window for sensitising effects of inflammation on hypoxic-ischaemic brain injury..
    • Kendall GS, Robertson NJ, Iwata I, Peebles D, Raivich G (2006). N-Methyl-isobutyl-amiloride ameliorates brain injury when commenced before hypoxia-ischaemia in neonatal mice. Pediatric Research, , - .
    • Lloyd J, Riley K, Wyatt J, Peebles D (2006). The influence of birthweight for gestational age on neurodevelopmental outcome at 1 year of age in premature infants..
    • David ALM, Peebles DM, Gregory L, Waddington SN, Themis M, WeiszB R, A L, L C, T R, C H C, C (2006). Clinically applicable procedure for gene delivery to fetal gut by ultrasound-guided gastric injection: toward prenatal prevention of early-onset intestinal diseases.. Human Gene Therapy, 17(7), 767 - 769. doi:10.1089/hum.2006.17.767
    • Peebles D, Myatt L (2006). Inflammation and pregnancy.
    • Iwata O, Bainbridge A, Iwata S, DeVita E, West DA, Thornton JS, Shanmugalingam S, Cheong J, Priest A, Peebles D, Ordidge R, Cady EB, Wyatt JS, Robertson NJ (2006). Cerebral insult severity, therapeutic time window and regional severity of secondary energy failure in newborn piglets.

    2005

    • Iwata O, Iwata S, Thornton J, DeVita E, Bainbridge A, West DA, Raivich G, Peebles D, Ordidge R, Cady E, Wyatt J, Robertson N (2005). Delayed hypothermia, "latent phase" and neuronal injury in a piglet model of hypoxia-ischaemia.
    • Coutelle C, Themis M, Waddington SN, Buckley SMK, Gregory LG, Nivsarkar MS, David AL, Peebles D, Weisz B, Rodeck C (2005). Gene therapy progress and prospects: Fetal gene therapy - first proofs of concept - some adverse effects. GENE THER, 12(22), 1601 - 1607.
    • Peebles DM (2005). Management of preterm premature ruptured membranes.. In Norman J, Greer IA (Ed.), Preterm Delivery: Managing risk in clinical practice (pp. - ). : Cambridge University Press.
    • Ordidge RJ, Carmichael DW, Wang X, Peebles DM (2005). Perinatal MR studies in animal models.. In (Ed.), Biomedical Magnetic Resonance (pp. 141-154 - 154). : Jaypee Brothers.
    • Kendall G, Peebles D (2005). Acute fetal hypoxia: the modulating effect of infection.. Early Hum Dev, 81(1), 27 - 34. doi:10.1016/j.earlhumdev.2004.10.012
    • Iwata O, De Vita E, Bainbridge A, Iwata S, West DA, Raivich G, Peebles D, Cady EB, Ordidge R, Wyatt JS, Robertson NJ (2005). Cerebral energy depletion during hypoxia-ischaemia, therapeutic window, and regional severity of secondary energy failure in newborn piglets.
    • Iwata O, Bainbridge A, Iwata S, West DA, De Vita E, Thornton JS, Raivich G, Peebles D, Cady EB, Ordidge R, Wyatt J, Robertson N (2005). Evolution of secondary energy failure is spatially heterogeneous in a piglet model..
    • Carmichael DW, Wang X, Bainbridge A, Thornton JS, Cady EB, Raivich G, Ordidge RJ, Peebles DM (2005). The response to acute hypoxia and infection studied by MRI/MRS in a chicken embryo model of perinatal brain injury..
    • Iwata O, De Vita E, Bainbridge A, Iwata S, West DA, Raivich G, Peebles D, Cady EB, Ordidge R, Wyatt JS, Robertson NJ (2005). Cerebral energy depletion during hypoxia-ischaemia, duration of “therapeutic window”, and regional severity of secondary energy failure in piglets..
    • Weisz B, David AL, Gregory LG, Perocheau D, Ruthe A, Waddington SN, Themsis M, Cook T, Coutelle C, Rodeck CH, Peebles DM (2005). Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy.. American Journal of Obstetrics and Gynecology, 193(3pt2), 1105 - 1109. doi:10.1016/j.ajog.2005.06.077
    • Dixon JC, Cady EB, Priest AN, Thornton JS, Peebles DM (2005). Growth restriction and the cerebral metabolic response to acute hypoxia of chick embryos in-ovo: a proton magnetic resonance spectroscopy study.. Developmental Brain Research, 160(2), 203 - 210.
    • Coutelle C, Themis M, Waddington SN, Buckley SM, Gregory LG, Nivsarkar MS, David AL, Peebles D, Weisz B, Rodeck C (2005). Gene Therapy Progress and Prospects: Fetal gene therapy - first proofs of concept - some adverse effects. Gene Therapy, 12, 1601 - 1607.
    • Iwata O, Bainbridge A, Iwata S, West DA, De Vita E, Thornton JS, Raivich G, Peebles D, Cady EB, Ordidge R, Wyatt JS, Robertson NJ (2005). Evolution of secondary energy failure is spatially heterogeneous in a piglet model..
    • Iwata O, Thornton JS, Sellwood MW, Iwata S, Sakata Y, Noone MA, O'Brien FE, Bainbridge A, De Vita E, Raivich G, Peebles D, Scaravilli F, Cady EB, Ordidge R, Wyatt JS, Robertson NJ (2005). Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia.. Annals of Neurology, 58(1), 75 - 87. doi:10.1002/ana.20528
    • Hall NJ, Ade-Ajayi N, Peebles D, Pierro A (2005). Antenatally diagnosed duplication cyst of the tongue: modern imaging modalities assist perinatal management. PEDIATR SURG INT, 21(4), 289 - 291.
    • Morrison JJ, Chitty LS, Peebles D, Rodeck CH (2005). Recreational drugs and fetal gastroschisis: maternal hair analysis in the peri-conceptional period and during pregnancy. BJOG., 112(8), 1022 - 1025.
    • Kendall G, Peebles D (2005). Acute fetal hypoxia: the modulating effect of infection.. Early Human Development, 81, 27 - 34.

    2004

    • Peebles DM, Gregory LG, David A, Themis M, Waddington SN, Knapton HJ, Miah M, Cook T, Lawrence L, Nivsarkar M, Rodeck CH, Coutelle C (2004). Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero.. Gene Therapy, 11, 70 - 78. doi:10.1038/sj.gt.3302130
    • Weisz B, David AL, Peebles DM, Perocheau D, Themis M, Cook T, Coutelle C, Rodeck CH (2004). Ultrasound guided delivery of gene therapy to the early gestation fetal sheep brain..
    • Peebles D (2004). Twin-to-twin transfusion syndrome:treatment with endoscopic laser surgery or serial amnio-reduction?. BJOG, 111, 1305 - 1306.
    • Wang X, Dixon J, Raivich G, Peebles D (2004). The effect of endotoxin and hypoxia on the brain of chick embryos in ovo..
    • Weisz B, David AL, Peebles DM, Gregory L, Perocheau D, Themis M, Cook T, Coutelle C, Rodeck CH (2004). Targeting the fetal gut for prenatal gene therapy..
    • Peebles D (2004). Fetal consequences of chronic substrate deprivation.. Seminars in Fetal and Neonatal Medicine, 9, 379 - 386.
    • Wang XL, Dixon J, Raivich G, Peebles D (2004). The effect of endotoxin and hypoxia on the brain of chick embryos in ovo..
    • David A, Weisz B, Peebles D, Roubliova X, Perocheau D, Themis M, Cook T, Coutelle C, Deprest J, Rodeck C (2004). Ultrasound guided placement of an occlusive balloon in the trachea of fetal sheep.
    • David AL, Peebles D, Gregory L, Themis M, Cook T, Nivsarkar M, Perocheau D, Weisz B, Rodeck CH, Coutelle C (2004). Towards prenatal gene therapy for cystic fibrosis: ultrasound guided delivery of recombinant adenoviral vectors to the fetal sheep trachea results in efficient marker gene expression in the airway epithelia.
    • Camilleri RS, Peebles D, Portmann C, Everington T, Cohen H (2004). -455G/A beta-fibrinogen gene polymorphism, factor V Leiden, prothrombin G20210A mutation and MTHFR C677T, and placental vascular complications.. Blood Coagul Fibrinolysis, 15(2), 139 - 147.
    • Camilleri RS, Peebles D, Portmann C, Everington T, Cohen H (2004). -455G/A fibrinogen gene polymorphism, factor V Leiden, prothrombin G20210A mutation and MTHFR C677T and placental vascular complications. Blood coagulation and fibrinolysis, 15, 139 - 147.
    • Smith RP, Miller SL, Igosheva N, Peebles DM, Glover V, Jenkin G, Hanson MA, Fisk NM (2004). Cardiovascular and endocrine responses to cutaneous electrical stimulation after fentanyl in the ovine fetus. American Journal of Obstetrics and Gynecology, 190(3), 836 - 842.
    • Iwata O, De Vita E, O'Brien F, Thornton JS, Iwata S, Peebles D, Scaravilli F, Cady EB, Ordidge RJ, Wyatt JS, Robertson NJ (2004). Delayed hypothermia is neuroprotective in moderate, but not severe, perinatal hypoxic-ischaemic brian injury.
    • Iwata O, De Vita E, Thornton J, O'Brien F, Iwata S, Shanmugalingam S, Peebles D, Scaravilli F, Cady E, Ordidge R, Wyatt JS, Robertson NJ (2004). Delayed hypothermia is neuroprotective in moderate, but not severe, perinatal hypoxic-ischaemic injury..
    • Weisz B, David A, Peebles D, Gregory L, Perocheau D, Waddington S, Themis M, Cook T, Coutelle C, Rodeck C (2004). Targeting the fetal respiratory muscles for prenatal gene therapy for Duchenne muscular dystrophy.
    • Peebles D, Gregory LG, David A, Themis M, Waddington SN, Knapton HJ, Miah M, Cook T, Lawrence L, Nivsarkar M, Rodeck C, Coutelle C (2004). Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero. GENE THER, 11(1), 70 - 78. doi:10.1038/sj.gt.3302130
    • Weisz B, David AL, Peebles DM, Gregory L, Perocheau D, Themis M, Terry C, Coutelle C, Rodeck CH (2004). Targeting the fetal gut for prenatal gene therapy..
    • Kendall G, Peebles D (2004). Acute fetal hypoxia: the modulating effect of infection.. Early Human Development, 81, 27 - 34.
    • Peebles DM (2004). Fetal growth restriction.. Seminars in Fetal and Neonatal Medicine, 9, 355 - 356.

    2003

    • Thiruchelvam N, Nyirady P, Peebles DM, Fry CH, Cuckow PM, Woolf AS (2003). Urinary outflow obstruction increases apoptosis and deregulates Bcl-2 and Bax expression in the fetal ovine bladder. American Journal of Pathology, 162(4), 1271 - 1282.
    • Peebles DM, Dixon JC, Thornton JS, Cady EB, Priest A, Miller SL, Blanco CE, Mulder AL, Ordidge RJ, Rodeck CH (2003). Magnetic resonance proton spectroscopy and diffusion weighted imaging of chick embryo brain in ovo. Developmental Brain Research, 141(1-2), 101 - 107. doi:10.1016/S0165-3806(03)00002-6
    • David AL, Themis M, Waddington SN, Gregory L, Buckley SMK, Nivsarkar M, Cook T, Peebles D, Rodeck CH, Coutelle C (2003). The current status and future direction of fetal gene therapy. Gene Therapy and Molecular Biology, 7, 181 - 209.
    • Green LR, Englefield PE, Miller S, Anthony FW, Bal M, Peebles D, Hanson MA, Blanco CE (2003). The effect of chronic hypoxia and protein malnutrition on IGF axis expression in the chick at hatching.
    • Gregory LG, Peebles D, David A, Themis M, Waddington SN, Knapton HJ, Miah M, Terry C, Lawrence L, Nivsarkar M, Rodeck C, Coutelle C (2003). Widespread and efficient adenovirus-mediated gene transfer to the airways by DEAE dextran and sodium caprate in adult mice and fetal sheep after minimally invasive tracheal application.
    • Chipchase J, Peebles DM, Rodeck CH (2003). Severe pre-eclampsia and cerebral blood volume response to postural change. Obstetrics and Gynecology, 101(1), 86 - 92. doi:10.1016/S0029-7844(02)02443-2
    • Thornton J, Dixon JC, Priest AN, Bainbridge A, Cady E, Rodeck CH, Peebles DM, Ordidge RJ (2003). Proton-MRS of transient cerebral hypoxia in a chicken embryo model of fetal growth restriction.
    • Peebles DM, Miller S, Newman JP, Scott R, Hanson MA (2003). The effect of systemic administration of lipopolysaccharide on cerebral haemodynamics and oxygenation in the 0.65 gestation ovine fetus in utero. British Journal of Obstetrics and Gynaecology, 110(8), 735 - 743.
    • Mallard C, Odeback AK, Peebles D, Hagberg H, Kjellmer I (2003). White matter injury following systemic endotoxaemia and asphyxia in the fetal sheep. Neurochemical Research, 28, 215 - 223.
    • David AL, Peebles DM, Gregory L, Themis M, Cook T, Coutelle C, Rodeck CH (2003). Percutaneous ultrasound-guided injection of the trachea in fetal sheep: a novel technique to target the fetal airways. Fetal Diagnosis and Therapy, 18, 385 - 390.
    • Coutelle C, Themis M, Waddington S, Gregory L, Nivsarkar M, Buckley S, Cook T, Rodeck C, Peebles D, David A (2003). The hopes and fears of in utero gene therapy for genetic disease - a review. Placenta, 24, S114 - S121.
    • David ALM, Cook T, Waddington S, Peebles D, Nivsarkar M, Knapton H, Miah M, Dahse T, Noakes D, Schneider H, Rodeck CH, Coutelle C, Themis M (2003). Ultrasound guided percutaneous delivery of adenoviral vectors encoding the beta-galactosidase and human factor IX genes to early gestation fetal sheep in utero. Human Gene Therapy, 14, 353 - 364. doi:10.1089/104303403321208952

    2002

    • Peebles DM, Hanson MA (2002). Antepartum hypoxia and the developing fetus. In Donn SM, Sinha SK, Chiswick ML (Ed.), Current Issues in Fetal and Neonatal Asphyxial Brain Injury (pp. - ). : Future Publishing Co.
    • Chipchase J, Kirkby D, Peebles DM, Cope M, Rodeck CH (2002). Cerebral haemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labour. Journal of Perinatal Medicine, 30, 502 - 509.
    • David AL, Peebles DM, Themis M, Cook T, Coutelle C, Rodeck CH (2002). In utero gene therapy using an adenoviral vector in the fetal sheep at early gestation.
    • Hagberg H, Peebles D, Mallard C (2002). Models of white matter injury: comparison of infectious, hypoxic-ischaemic and excitotoxic insults. Mental Retardation and Developmental Disabilities Research Reviews, 8, 30 - 38.
    • Miller SL, Green LR, Peebles DM, Hanson MA, Blanco CE (2002). Effects of chronic hypoxia and protein malnutrition on growth in the developing chick. American Journal of Obstetrics and Gynecology, 186, 261 - 267.
    • Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJD, Peebles DM, Woolf AS, Cuckow PM (2002). Fetal sheep bladder outflow obstruction perturbs detrusor contractility, volume-pressure relationships and innervation. The Journal of Urology, 168, 1615 - 1620.
    • Nyirady P, Thiruchelvam N, Fry CH, Godley ML, Winyard PJ, Peebles DM, Woolf AS, Cuckow PM (2002). Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation. The Journal of Urology, 168(4), 1615 - 1620.
    • Nyirady P, Thiruchelvam N, Cuckow PM, Fry CH, Peebles DM, Woolf AS (2002). Cell turnover in the developing and obstructed fetal bladder. doi:10.1046/j.1464-410X.89.s2.2.x
    • David AL, Peebles DM, Miah M, Themis M, Nivsarkar M, Tucker N, Dahse T, Cook T, Coutelle C, Rodeck CH (2002). Ultrasound-guided delivery of viral vectors encoding the beta-galactosidase and human factor IX genes to early gestation fetal sheep in utero. Journal of Obstetrics and Gynaecology, 22(Supple), - .
    • Peebles DM, Wyatt JS (2002). Synergy between antenatal exposure to infection and intrapartum events in causation of perinatal brain injury at term. British Journal of Obstetrics and Gynaecology, 109, 737 - 739.

    2001

    • Newman JP, Peebles DM, Hanson MA (2001). Adenosine produces changes in cerebral hemodynamics and metabolism as assessed by near-infrared spectroscopy in late-gestation fetal sheep in utero.. Pediatr Res, 50(2), 217 - 221. doi:10.1203/00006450-200108000-00009
    • Deng J, Kalache KD, Hanson MA, Peebles DM, Linney AD, Lees WR, Rodeck CH (2001). Conversion of Umbilicial Arterial Doppler Waveforms (UADWs) to Cardiac Cycle Triggering Signals (CCTSs) - A Preparatory Study of On-Line Motion-Gated Three-Dimensional (3D) Fetal Echocardiography. Ultrasound in Medicine and Biology, 27(1), 51 - 59.
    • Kalache KD, Masturzo B, Pierro A, Peebles D, Chitty LS (2001). Prenatal evaluation of fetal neck masses in preparation for the EXIT procedure: the value of pulmonary Doppler ultrasonography (PDU). Prenat.Diagn., 21(4), 308 - 310.
    • Miller SL, Peebles DM, Thornton J, Ordidge R, Cady EB, Mulder T, Blanco CE (2001). Magnetic resonance imaging and spectroscopy of developing chick brain during normoxia and hypoxia..
    • Thornton J, Cady EB, Ordidge RJ, Miller S, Peebles DM (2001). Transient hypoxia studied by proton spectroscopy and diffusion-weighted imaging in embryonic chicken brain in ovo..
    • Miller SL, Green LR, Peebles DM, Hanson MA, Blanco CE (2001). Effects of chronic hypoxia and protein malnutrition on growth in the developing chick. American Journal of Obstetrics and Gynecology, 186(2), 261 - 267.
    • Thornton J, Cady EB, Ordidge RJ, Miller S, Peebles DM (2001). Transient hypoxia studied by proton spectroscopy and diffusion-weighted imaging in embryonic chicken brain in ovo.
    • David AL, Peebles DM, Themis M, Cook T, Coutelle C, Rodeck CH (2001). In utero gene therapy by ultrasound-guided percutaneous administration of adenovirus vector into the muscle of sheep.
    • Deng J, Birkett AG, Kalache KD, Hanson MA, Peebles DM, Linney AD, Lees WR, Rodeck CH (2001). Conversion of umbilical arterial doppler waveforms to cardiac cycle triggering signals : A preparatory study for online motion-gated three-dimensional fetal echocardiography. Ultrasound in Medicine and Biology, 27(1), 51 - 59.
    • Nyirady P, Thiruchevlan N, Fry CH, Peebles DH, Godley ML, Winyard PJD, Woolf AS, Rodeck CH, Cuckow PH (2001). PUV in an animal model - electromechanical properties of detrusor smooth muscle. doi:10.1046/j.1464-410X.2001.0880s1001.x

    2000

    • Miller SL, Green LR, Peebles DM, Hanson MA, Blanco CE (2000). Limitation of fetal growth in conditions of chronic hypoxia and/or malnutrition. PEDIATR RES, 47(4), 292A - 292A.
    • Deng J, Birkett AG, Kalache KD, Hanson MA, Peebles DM, Linney AD, Lees WR, Rodeck CH (2000). Conversion of Doppler spectra to 'ECG' triggering signals for on-line motion-gated three-dimensional fetal echocardiography..
    • Peebles DM, O'Brien P (2000). New optical methods of intrapartum fetal surveillance. In Rodeck CH, Whittle M (Ed.), Fetal Medicine: Basic Science and Clinical Practice (pp. - ). : W.B.Saunders. London UK.
    • Newman JP, Peebles DM, Harding SR, Springett R, Hanson MA (2000). Hemodynamic and metabolic responses to moderate asphyxia in brain and skeletal muscle of late-gestation fetal sheep. Journal of Applied Physiology, 88(1), 82 - 90.
    • Chipchase J, Peebles DM (2000). Management of antepartum fetal death. In Baker P, Kingdom J (Ed.), Intrauterine Growth Restriction (pp. - ). : Springer-Verlag..

    1999

    • Newman J, Peebles D, Harding S, Hanson MA (1999). Changes in the redox state of cytochrome oxidase during administration of adenosine to unanaesthetised fetal sheep in utero.
    • Chipchase J, Kirkby DR, Cope M, Peebles D (1999). Absolute cerebral haemoglobin concentration and oxygen saturation measurements with an intensity modulated optical spectrometer in the fetus during labour.

    1998

    • Bennet L, Peebles DM, Edwards AD, Rios A, Hanson MA (1998). The cerebral hemodynamic response to asphyxia and hypoxia in the near-term fetal sheep as measured by near infrared spectroscopy. Pediatric Research, 44(6), 1 - 7.
    • Newman JP, Harding S, Peebles DM, Hanson MA (1998). Comparison of brain cytochorme oxidase oxidation state in the adaptation to moderate and severe asphyxia in the unanaesthetised near-term fetal sheep using near infrared spectroscopy.
    • Newman JP, Peebles DM, Hanson MA (1998). Changes in the concentration of oxidised cytochrome oxidase measured by near infrared spectroscopy simultaneously in the brain and carcass muscle of unanaesthetised fetal sheep during acute hypoxaemia. Journal of the Society for Gynecologic Investigation, 5, 155a - .
    • Peebles DM, Newman JP, Harding S, Hanson MA (1998). Changes in the redox state of cytochrome oxidase during administration of adenosine to unanaesthetised fetal sheep in utero.
    • Bennet L, Peebles DM, Edwards AD, Rios A, Hanson MA (1998). The cerebral hemodynamic response to asphyxia and hypoxia in the near-term fetal sheep as measured by near infrared spectroscopy.. Pediatr Res, 44(6), 951 - 957. doi:10.1203/00006450-199812000-00022
    • Newman JP, Peebles D, Harding S, Springett R, Hanson MA (1998). Cardiovascular redistribution and tissue oxygenation measured by near-infrared (NIR) spectroscopy in unanaesthetized fetal sheep. J PHYSIOL-LONDON, 507P, 52P - 53P.
    • Peebles DM (1998). Holoprosencephaly. Prenatal Diagnosis, 18, 477 - 480.

    1997

    • Peebles DM, O'Brien P (1997). Fetal cerebral oxygenation and haemodynamics during labour measured by near infrared spectroscopy. Mental Retardation and Developmental Disabilities Research Reviews, 3, 59 - 68.
    • Peebles DM (1997). Cerebral haemodynamics and oxygenation in the fetus: the role of intrapartum near infrared spectroscopy. Clinics in Perinatology, 24(3), 547 - 566.

    1995

    • Aldrich CJ, D'Antona D, Spencer JA, Wyatt JS, Peebles DM, Delpy DT, Reynolds EO (1995). Late fetal heart decelerations and changes in cerebral oxygenation during the first stage of labour. BJOG: An International Journal of Obstetrics and Gynaecology, 102, 9 - 13.
    • Aldrich CJ, D'Antona D, Spencer JA, Wyatt JS, Peebles DM, Delpy DT, Reynolds EO (1995). The effect of maternal pushing on fetal cerebral oxygenation and blood volume during the second stage of labour. BJOG: An International Journal of Obstetrics and Gynaecology, 102, 448 - 453.
    • Aldrich CJ, D'Antona D, Spencer JA, Wyatt JS, Peebles DM, Delpy DT, Reynolds EO (1995). The effect of maternal posture on fetal cerebral oxygenation during labour.. BJOG: An International Journal of Obstetrics and Gynaecology, 102, 14 - 19.
    • OBRIEN P, MORRISON J, ELREFAEY H, LAWRENCE S, BOWER SJ, PEEBLES D, BROADBENT M, GORDON A, BURRELL S (1995). DOCTORS WHO SMOKE - DOCTORS SHOULD ADVISE BUT DO NOT HAVE TO LEAD BY EXAMPLE. BRIT MED J, 311(7010), 945 - 945.

    1994

    • LOREK A, CADY E, PENRICE J, WYATT J, TAKEI Y, EDWARDS D, WYLEZINSKA M, KIRKBRIDE V, OWENREECE H, BROWN G, ALDRIDGE R, PEEBLES D, COOPER C, ROTH S, DELPY D, REYNOLDS O (1994). CEREBRAL LACTATE AND N-ACETYLASPARTATE/CHOLINE RATIOS AND DELAYED ENERGY FAILURE FOLLOWING ACUTE HYPOXIA-ISCHEMIA IN THE NEWBORN PIG. PEDIATR RES, 36(1), A25 - A25.
    • Peebles DM, Spencer JA, Edwards AD, Wyatt JS, Reynolds EO, Cope M, Delpy DT (1994). Relation between frequency of uterine contractions and human fetal cerebral oxygen saturation studied during labour by near infrared spectroscopy. BJOG: An International Journal of Obstetrics and Gynaecology, 101, 44 - 48.
    • Lorek A, Takei Y, Peebles D, Edwards AD, Roth S, Cady E, Wyatt JS, for TUCLPBRG (1994). Secondary energy failure after acute cerebral hypoxia-ischaemia in newborn pigs..
    • BENNET L, PEEBLES DM, EDWARDS AD, HANSON MA (1994). CEREBRAL HEMODYNAMIC-CHANGES IN UNANESTHETIZED FETAL SHEEP MEASURED BY NEAR-INFRARED SPECTROSCOPY (NIRS) IN ACUTE-HYPOXIA. J PHYSIOL-LONDON, 479P, P24 - P25.
    • Aldrich CJ, D'Antona D, Wyatt JS, Spencer JA, Peebles DM, Reynolds EO (1994). Fetal cerebral oxygenation measured by near-infrared spectroscopy shortly before birth and acid-base status at birth. Obstetrics and Gynecology, 84, 861 - 866.
    • Lorek A, Cady EB, Takei Y, Wyatt JS, Penrice J, Edwards AD, Peebles D, Wylezinska M, Owen-Reece H, Kirkbride V, Cooper C, Aldridge RF, Roth SC, Brown G, Delpy DT, Reynolds EOR (1994). Relation between cerebral nucleotide triphosphate depletion due to acute hypoxia-ischaemia and secondary energy failure in the newborn piglet..
    • Lorek A, Cady EB, Penrice JM, Wyatt JS, Takei Y, Edwards AD, Wylezinska M, Kirkbride V, Owen-Reece H, Brown G, Aldridge RF, Peebles D, Cooper C, Roth S, Delpy DT, Reynolds EOR (1994). Cerebral lactate and N-acetylaspartate/choline ratios and delayed energy failure following acute hypoxia-ischaemia in the newborn pig..
    • Lorek A, Takei Y, Cady EB, Wyatt JS, Penrice J, Edwards AD, Peebles D, Wylezinska M, Owen-Reece H, Kirkbride V (1994). Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatric Research, 36(6), 699 - 706.
    • ALDRICH CJ, DANTONA D, WYATT JS, SPENCER JAD, PEEBLES DM, DELPY DT, REYNOLDS EOR (1994). HUMAN FETAL CEREBRAL OXYGEN-SATURATION (SMCO(2)) MEASURED DURING LABOR CAN PREDICT ACID-BASE STATE AT DELIVERY. PEDIATR RES, 36(1), A3 - A3.

    1993

    • Takei Y, Edwards AD, Lorek A, Peebles DM, Belai A, Cope M, Delpy DT, Reynolds EO (1993). Effects of N-omega-nitro-L-arginine methyl ester on the cerebral circulation of newborn piglets quantified in vivo by near-infrared spectroscopy. Pediatric Research, 34, 354 - 359.
    • EDWARDS AD, TAKEI Y, PEEBLES DM, LOREK A, COPE M, DELPY DT, REYNOLDS EOR (1993). INVIVO QUANTITATION OF EFFECTS OF L-NAME ON THE CEREBRAL-CIRCULATION OF ANESTHETIZED NEWBORN PIGLETS BY NEAR-INFRARED SPECTROSCOPY. J PHYSIOL-LONDON, 459, P193 - P193.
    • Cady EB, Wyatt JS, Takei Y, Lorek A, Penrice J, Edwards AD, Roth S, Brown G, Peebles D, Owen-Reece H, Kirkbride V, Aldridge RF, Wylezinska M, Cooper C, Delpy DT, Reynolds EOR (1993). Cerebral energy failure secondary to acute hypoxia-ischaemia: Continuous 7 tesla 31P and 1H magnetic resonance spectroscopy studies over 48 hours..
    • Cady EB, Wyatt JS, Takei Y, Lorek A, Cooper C, Edwards AD, Roth S, Peebles D, Aldridge RF, Wylezinska M, Delpy DT, Reynolds EOR (1993). Cerebral energy failure secondary to acute hypoxia-ischaemia in the newborn pig studied by 1H magnetic resonance spectroscopy..
    • Wyatt JS, Peebles DM (1993). Near infrared spectroscopy and intrapartum fetal surveillance. In Spencer JADS, Ward RHT (Ed.), Intrapartum Fetal Surveillance (pp. 329 - 342). : RCOG Press.
    • Peebles DM, Wyatt JS (1993). Near infrared spectroscopy and intrapartum fetal monitoring. Contemporary Reviews in Obstetrics and Gynaecology, 5, 124 - 129.
    • Cady EB, Wyatt JS, Lorek A, Takei Y, Penrice J, Edwards AD, Roth S, Brown G, Peebles D, Owen-Reece H, Kirkbride V, Aldridge RF, Wylezinska M, Cooper C, Delpy DT, Reynolds EOR (1993). Delayed cerebral energy failure following recovery from acute hypoxia-ischaemia in the newborn piglet: 31P and 1H magnetic resonance spectroscopy studies..
    • Cady EB, Wyatt JS, Takei Y, Lorek A, Edwards AD, Roth S, Peebles D, Aldridge RF, Wylezinska M, Delpy DT, Reynolds EOR (1993). 31P magnetic resonance spectroscopy studies of cerebral energy failure secondary to acute hypoxia-ischaemia in the newborn pig..

    1992

    • Peebles DM, Edwards AD, Wyatt JS, Cope M, Delpy DT, Reynold EO (1992). Changes in human fetal cerebral oxygenation and blood volume during delivery.. American Journal of Obstetrics and Gynecology, 167, 1916 - 1917.
    • Edwards AD, McCormick DC, Roth SC, Elwell CE, Peebles DM, Cope M, Wyatt JS, Delpy DT, Reynolds EO (1992). Cerebral hemodynamic effects of treatment with modified natural surfactant investigated by near infrared spectroscopy. Pediatric Research, 32(2), 532 - 536.
    • Peebles DM, Edwards AD, Wyatt JS, Bishop AP, Cope M, Delpy DT, Reynolds EO (1992). Changes in human fetal cerebral hemoglobin concentration and oxygenation during labor measured by near-infrared spectroscopy.. American Journal of Obstetrics and Gynecology, 166, 1369 - 1373.

    1991

    • Peebles DM, Edwards AD, Wyatt JS, Bishop AP, Cope M, Delpy DT, Reynolds EO (1991). Effect of oxytocin on fetal brain oxygenation during labour. The Lancet, 338(8761), 254 - 255.