Prof David Abraham

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Personal Profile

Name: David Abraham Email: david.abraham@ucl.ac.uk
Title: Prof Tel: 0207 794 0432
Department: Inflammation Fax: 0207 830 2428
Position: Professor of Cell and Molecular Biology Address: Royal Free Campus, Rowland Hill Street, London, NW3 2PF
Research Domain: Basic Life Sciences, Cardiometabolic Science, Experimental Medicine, Infection, Immunology & Inflammation, Personalised Medicine, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

Profile

Research Description

Our research programme employs basic scientific, clinical and translational methodologies to address fundamental questions related to diseases pathogenesis, assessment and treatment of connective tissue disease, specifically focusing on the scleroderma spectrum. The laboratory research focuses on understanding basic disease mechanisms in connective tissue disease and fibrosis. This has potential impact far beyond SSc. Five major research areas have emerged: 1. Biomarkers for disease including autoantibody profiles 2. Novel pro-inflammatory and fibrotic mediators 3. The origins of fibroblasts and myofibroblast differentiation 4. Molecular genetics of disease sub-sets 5. Development and study of Pre-clinical models. We have a unique clinical resource consisting of patient sample banks comprising of an ever increasing number of new and serial serum and plasma samples across the disease spectrum. We also have a tissue and cell bank which contains OCT and paraffin embedded tissue samples (skin, lung, Kidney) and frozen paired fibroblast cell lines (from lesional and non-lesional sites), and control fibroblast lines. Our genetic studies are supported by a nucleic acid bank which houses genomic DNA and RNA from over 4,000 patients within the disease spectrum. Our candidate gene approach links to gene and protein expression profiling analysis using microarrays, SNP genechips and proteomics. We have also utilised and developed a number of pre-clinical models for scleroderma. These include both inflammatory and non-inflammatory driven animal models of connective tissue scarring and fibrosis affecting the skin, heart, lungs, muscle, and kidney. These pre-clinical models in addition to primary cultures of leukocyte populations and fibroblasts have proved invaluable for the assessment of anti-inflammatory, immuno-modulators and anti-fibrotic compounds prior to their use in clinical trials.

Research Activities

Inflammatory-driven fibrosis

Mechanisms of tissue repair, scarring and fibrosis

Molecular pathogenesis of fibroproliferative lung disease

Education Description

UCL Collaborators

Dr Jill Norman; Dr Shlomit Flint Ashery; Prof Rachel Chambers; Prof Christopher Denton; Prof Jim Owen; Miss Janice Tsui; Dr Robin Mcanulty; Dr Mick Dashwood; Dr Marilena Loizidou

External Collaborators

Karen Lyons; Darryl Knight; Gisli Jenkins; Benoit De Crombrugghe; James Bonner; Kristofer Rubin; Thomas Kreig; Oliver Distler; Andrew Leask

Publications

    2013

    • Maurer B, Distler A, Dees C, Khan K, Denton CP, Abraham D, Gay RE, Michel BA, Gay S, Distler JH, Distler O (2013). Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors.. Ann Rheum Dis, , - . doi:10.1136/annrheumdis-2013-203729
    • Wolf SI, Howat S, Abraham DJ, Pearson JD, Lawson C (2013). Agonistic anti-ICAM-1 antibodies in scleroderma: Activation of endothelial pro-inflammatory cascades. VASCULAR PHARMACOLOGY, 59(1-2), 19 - 26. doi:10.1016/j.vph.2013.05.002
    • Lindahl GE, Stock CJ, Shi-Wen X, Leoni P, Sestini P, Howat SL, Bou-Gharios G, Nicholson AG, Denton CP, Grutters JC, Maher TM, Wells AU, Abraham DJ, Renzoni EA (2013). Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.. Respir Res, 14, 80 - . doi:10.1186/1465-9921-14-80
    • Hart CA, Tsui J, Khanna A, Abraham DJ, Baker DM (2013). Stem cells of the lower limb: Their role and potential in management of critical limb ischemia.. Exp Biol Med (Maywood), , - . doi:10.1177/1535370213503275
    • Abraham D, Handler C, Pearson J (2013). Translational cardiovascular research in the quest for new therapies. VASCULAR PHARMACOLOGY, 58(3), V - V. doi:10.1016/S1537-1891(13)00027-X
    • Sonnylal S, Shiwen X, Jones H, Tam A, Sreeram VR, Ponticos M, Norman JT, Agrawal P, Abraham DJ, de Crombrugge B (2013). Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. Journal of Cell Science, , - .
    • Donovan J, Abraham D, Norman J (2013). Platelet-derived growth factor signaling in mesenchymal cells.. Front Biosci (Landmark Ed), 18, 106 - 119.
    • Stock CJ, Sato H, Fonseca C, Banya WA, Molyneaux PL, Adamali H, Russell AM, Denton CP, Abraham DJ, Hansell DM, Nicholson AG, Maher TM, Wells AU, Lindahl GE, Renzoni EA (2013). Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.. Thorax, 68(5), 436 - 441. doi:10.1136/thoraxjnl-2012-201786
    • Donovan J, Shiwen X, Norman J, Abraham D (2013). Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts.. Fibrogenesis Tissue Repair, 6(1), 10 - . doi:10.1186/1755-1536-6-10
    • Haque SU, Dashwood MR, Heetun M, Shiwen X, Farooqui N, Ramesh B, Welch H, Savage FJ, Ogunbiyi O, Abraham DJ, Loizidou M (2013). Efficacy of the specific endothelin A receptor antagonist zibotentan (ZD4054) in colorectal cancer: a preclinical study.. Mol Cancer Ther, , - . doi:10.1158/1535-7163.MCT-12-0975
    • Wedlake LJ, Khan K, Ahmedi B, Thomas K, Abraham D, Andreyev HJN (2013). Letter in Response to Article: A Pilot Study Examining Circulating Interleukin-6 and Transforming Growth Factor-beta Levels During Pelvic Radiation Therapy Reply. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 36(1), 102 - 103. doi:10.1097/COC.0b013e31827f18be
    • De Lauretis A, Sestini P, Pantelidis P, Hoyles R, Hansell DM, Goh NS, Zappala CJ, Visca D, Maher TM, Denton CP, Ong VH, Abraham DJ, Kelleher P, Hector L, Wells AU, Renzoni EA (2013). Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis.. J Rheumatol, 40(4), 435 - 446. doi:10.3899/jrheum.120725
    • Derrett-Smith EC, Dooley A, Gilbane A, Trinder S, Khan K, Baliga R, Holmes A, Hobbs A, Abraham D, Denton CP (2013). Endothelial injury in a TGFβ dependent mouse model of scleroderma induces pulmonary arterial hypertension.. Arthritis Rheum, , - . doi:10.1002/art.38078

    2012

    • Peters AS, Brunner G, Blumbach K, Abraham DJ, Krieg T, Eckes B (2012). Cyclic mechanical stress downregulates endothelin-1 and its responsive genes independently of TGF beta 1 in dermal fibroblasts. EXPERIMENTAL DERMATOLOGY, 21(10), 765 - 770. doi:10.1111/exd.12010
    • Shi-wen X, Thompson K, Khan K, Liu S, Murphy-Marshman H, Baron M, Denton CP, Leask A, Abraham DJ (2012). Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.. Rheumatology (Oxford), 51(12), 2146 - 2154. doi:10.1093/rheumatology/kes234
    • Khan K, Xu S, Nihtyanova S, Derrett-Smith E, Abraham D, Denton CP, Ong VH (2012). Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis.. Ann Rheum Dis, 71(7), 1235 - 1242. doi:10.1136/annrheumdis-2011-200955
    • Fragiadaki M, Witherden A, Mason RM, Abraham D (2012). High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. Mol Biol Cell, 22(11), 1836 - 1844. doi:10.1111/j.1469-7580.2011.01473.x
    • Moinzadeh P, Fonseca C, Abraham DJ, Ong VH, Denton CP (2012). ANALYSIS OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE IL-7R AND IL-7 GENE IN SSc PATIENTS.
    • Tam A, Sonnylal S, Leask A, Denton CP, de Crombrugghe B, Norman J, Abraham DJ (2012). EPITHELIAL-TO-MESENCHYMAL TRANSITION AND LUNG FIBROSIS.
    • Knowles JP, Shi-Wen X, Haque SU, Bhalla A, Dashwood MR, Yang S, Taylor I, Winslet MC, Abraham DJ, Loizidou M (2012). Endothelin-1 stimulates colon cancer adjacent fibroblasts.. Int J Cancer, 130(6), 1264 - 1272. doi:10.1002/ijc.26090
    • Khan K, Shiwen X, Abraham DJ, Denton CP, Ong V (2012). OVEREXPRESSION OF IL-6 IN EARLY dcSSc MAY DRIVE FIBROTIC RESPONSE VIA JAK2/STAT3 SIGNALLING PATHWAYS.
    • Lagares D, Busnadiego O, Lamas S, Rodríguez-Pascual F, García-Fernández RA, Kapoor M, Liu S, Leask A, Carter DE, Abraham D, Shi-Wen X, Carreira P, Fontaine BA, Shea BS, Tager AM (2012). Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis and Rheumatism, 64(5), 1653 - 1664. doi:10.1002/art.33482
    • Dooley A, Bruckdorfer KR, Abraham DJ (2012). Modulation of fibrosis in systemic sclerosis by nitric oxide and antioxidants.. Cardiol Res Pract, 2012, 521958 - . doi:10.1155/2012/521958
    • Joshi D, Tsui J, Yu R, Shiwen X, Selvakumar S, Abraham DJ, Baker DM (2012). Potential of Novel EPO Derivatives in Limb Ischemia.. Cardiol Res Pract, 2012, 213785 - . doi:10.1155/2012/213785
    • Moinzadeh P, Denton CP, Abraham D, Ong V, Hunzelmann N, Eckes B, Krieg T (2012). Biomarkers for skin involvement and fibrotic activity in scleroderma.. J Eur Acad Dermatol Venereol, 26(3), 267 - 276. doi:10.1111/j.1468-3083.2011.04206.x
    • Khan K, Thoua N, Dooley A, Derrett-Smith E, Ong V, Abraham DJ, Denton CP (2012). GUT FIBROSIS IS ASSOCIATED WITH REDUCED COLONIC CONTRACTILITY IN A TGF-beta MOUSE MODEL.

    2011

    • Denton CP, Hoyles RK, Derrett-Smith E, Abraham DJ (2011). Tissue-Specific Knockout/Knockdown of Type 2 TGF-beta Receptor and Protection against Bleomycin Injury/Fibrosis. AM J RESP CRIT CARE, 184(8), 983 - 984.
    • Hoyles RK, Derrett-Smith EC, Khan K, Shiwen X, Howat SL, Wells AU, Abraham DJ, Denton CP (2011). An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor.. Am J Respir Crit Care Med, 183(2), 249 - 261. doi:10.1164/rccm.201002-0279OC
    • Khan K, Shi-wen X, Abraham DJ, Denton CP, Ong V (2011). Enhanced IL-6 Trans-Signalling in Early dcSSc May Drive Fibrotic Response Via JAK2/STAT3 Signalling Pathways.
    • Derrett-Smith E, Hoyles R, Moinzadeh P, Chighizola CB, Khan K, Ong V, Abraham DJ, Denton CP (2011). Expression Profiling of Skin and Lung Tissue and Explanted Fibroblasts in a Transgenic Mouse Model of Scleroderma.
    • Chighizola CB, Moinzadeh P, Khan K, Wood TA, Meroni PL, Abraham DJ, Whitfield ML, Ong V, Denton CP (2011). Identification of a Gene Expression Signature in Limited Cutaneous Systemic Sclerosis That Includes Several Vascular Genetic Factors.
    • Derrett-Smith E, Dooley A, Baliga R, Hobbs A, Abraham DJ, Denton CP (2011). Intermittent Systemic VEGF Inhibition Induces Pulmonary Arterial Hypertension In a Transgenic Mouse Model of Scleroderma. Arthritis and Rheumatism, 63(10), S1022 - S1023.
    • Parapuram SK, Xu SW, Elliott C, Welch ID, Jones H, Baron M, Denton CP, Abraham DJ, Leask A (2011). Loss of PTEN Expression by Dermal Fibroblasts Causes Skin Fibrosis. J INVEST DERMATOL, 131(10), 1996 - 2003. doi:10.1038/jid.2011.156
    • Holmes AM, Ponticos M, Shi-Wen X, Denton CP, Abraham DJ (2011). Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin.. J Cell Commun Signal, 5(3), 173 - 177. doi:10.1007/s12079-011-0140-4
    • Morgan-Rowe L, Nikitorowicz J, Shiwen X, Leask A, Tsui J, Abraham D, Stratton R (2011). Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues.. Fibrogenesis Tissue Repair, 4, 13 - . doi:10.1186/1755-1536-4-13
    • Fragiadaki M, Ikeda T, Witherden A, Mason RM, Abraham D, Bou-Gharios G (2011). High doses of TGF-beta potently suppress type I collagen via the transcription factor CUX1. MOLECULAR BIOLOGY OF THE CELL, 22(11), 1836 - 1844. doi:10.1091/mbc.E10-08-0669
    • Wolf SI, Howat SL, Denton C, Abraham DJ, Pearson JD, Lawson C (2011). Identification of agonistic anti-ICAM-1 antibodies in serum from scleroderma patients.
    • Joshi D, Patel H, Baker DM, Shiwen X, Abraham DJ, Tsui JC (2011). Development of an in vitro model of myotube ischemia.. Lab Invest, 91(8), 1241 - 1252. doi:10.1038/labinvest.2011.79
    • Dashwood MR, Dooley A, Shi-Wen X, Abraham DJ, Dreifaldt M, Souza DS (2011). Perivascular fat-derived leptin: a potential role in improved vein graft performance in coronary artery bypass surgery.. Interact Cardiovasc Thorac Surg, 12(2), 170 - 173. doi:10.1510/icvts.2010.247874
    • Liu SX, Xu SW, Abraham DJ, Leask A (2011). CCN2 Is Required for Bleomycin-Induced Skin Fibrosis in Mice. ARTHRITIS RHEUM-US, 63(1), 239 - 246. doi:10.1002/art.30074
    • McCann MR, Monemdjou R, Ghassemi-Kakroodi P, Fahmi H, Perez G, Liu SX, Xu SW, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A, Kapoor M (2011). mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. ARTHRITIS RES THER, 13(1), - . doi:10.1186/ar3226
    • McCann MR, Monemdjou R, Ghassemi-Kakroodi P, Fahmi H, Perez G, Liu SX, Xu SW, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A, Kapoor M (2011). mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis (vol 13, pg 402, 2011). ARTHRITIS RES THER, 13(2), - . doi:10.1186/ar3285
    • Buniak JN, Shiwen X, Abraham DJ, Denton CD, Black CM, Stratton RJ (2011). Absence of Epithelial to Mesenchymal Transition Despite Activation of Keratinocytes in Scleroderma Skin.

    2010

    • Liu SX, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A (2010). Expression of integrin beta 1 by fibroblasts is required for tissue repair in vivo. J CELL SCI, 123(21), 3674 - 3682. doi:10.1242/jcs.070672
    • Fragiadaki M, Ikeda T, Mason R, Abraham D, Bou-Gharios G (2010). Repression of collagen type I by TGF-beta induced CUX1. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28(5), S65 - S65.
    • Dooley A, Shi-Wen X, Aden N, Tranah T, Desai N, Denton CP, Abraham DJ, Bruckdorfer R (2010). Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate.. Rheumatology (Oxford), 49(11), 2024 - 2036. doi:10.1093/rheumatology/keq208
    • Joshi D, Tsui J, Ho TK, Selvakumar S, Abraham DJ, Baker DM (2010). Review of the role of erythropoietin in critical leg ischemia.. Angiology, 61(6), 541 - 550. doi:10.1177/0003319709358697
    • Aden N, Nuttall A, Shiwen X, de Winter P, Leask A, Black CM, Denton CP, Abraham DJ, Stratton RJ (2010). Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis.. J Invest Dermatol, 130(9), 2191 - 2200. doi:10.1038/jid.2010.120
    • Fonseca C, Abraham DJ, Renzoni E (2010). Endothelin in Pulmonary Fibrosis. Am J Respir Cell Mol Biol, , - .
    • Derrett-Smith EC, Dooley A, Khan K, Shi-wen X, Abraham D, Denton CP (2010). Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma.. Arthritis Res Ther, 12(2), R69 - . doi:10.1186/ar2986
    • Eastwood M, Shi-wen X, Denton CP, Renzoni E, Abraham DJ (2010). Altered gene expression in fibroblasts cultured in 3-D collagen lattices subjected to biomechanical load.
    • Derrett-Smith EC, Dooley A, Khan K, Shi-wen X, Abraham DJ, Denton CP (2010). Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma.. Arthritis Res Ther., 12(2), - .
    • Shi-Wen X, Eastwood M, Denton CP, Leask A, Abraham DJ (2010). The PPAR gamma agonist rosiglitazone reverses the persistent fibrotic phenotype of scleroderma fibroblasts.
    • Eastwood M, Chen Y, Shi-wen X, Denton CP, Black CM, Abraham DJ (2010). Thrombospondin 1-a key mediator of matrix contraction depend on MEK/ERK in SSc pathogenesis.
    • Zolnowska M, Ponticos M, Pantelidis P, Denton CP, Abraham D, Fonseca C (2010). ANALYSIS OF POLYMORPHISMS IN THE HOMEOBOX TRANSCRIPTION FACTOR NKX2-5 GENE IN PATIENTS WITH SYSTEMIC SCLEROSIS. CLIN EXP RHEUMATOL, 28(2), S139 - S139.
    • Ho TK, Tsui J, Xu S, Leoni P, Abraham DJ, Baker DM (2010). Angiogenic effects of stromal cell-derived factor-1 (SDF-1/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia.. J Vasc Surg, 51(3), 689 - 699. doi:10.1016/j.jvs.2009.10.044
    • Rossi A, Sozio F, Sestini P, Renzoni EA, Khan K, Denton CP, Abraham DJ, Weber E (2010). Lymphatic and blood vessels in scleroderma skin, a morphometric analysis. HUM PATHOL, 41(3), 366 - 374. doi:10.1016/j.humpath.2009.08.009
    • Sonnylal S, Shi-wen X, Leoni P, Naff K, Van Pelt C, Nakamura H, Leask A, Bou-Gharios G, Abraham D, de Crombrugghe B (2010). Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.. Arthritis Rheum., 62(5), 1523 - 1532.
    • Shi-wen X, Eastwood M, Stratton RJ, Denton CP, Leask A, Abraham DJ (2010). Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.. Rheumatology (Oxford), 49(2), 259 - 263. doi:10.1093/rheumatology/kep371
    • Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D, Denton CP (2010). Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis. CLIN EXP RHEUMATOL, 28(5), S63 - S63.

    2009

    • Beirne P, Pantelidis P, Charles P, Wells AU, Abraham DJ, Denton CP, Welsh KI, Shah PL, du Bois RM, Kelleher P (2009). Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis. EUR RESPIR J, 34(6), 1376 - 1382. doi:10.1183/09031936.00028209
    • Aslam R, Khan K, Shiwen X, Abraham DJ, Black CM, Baker DM (2009). The Interplay of Matrix Metaloproteinases and tissue inhibitors of matrix metaloproteinases may account for basement membrane changes in critical limb ischaemia.
    • Liu SX, Kapoor M, Denton CP, Abraham DJ, Leask A (2009). Loss of beta 1 Integrin in Mouse Fibroblasts Results in Resistance to Skin Scleroderma in a Mouse Model. ARTHRITIS RHEUM, 60(9), 2817 - 2821. doi:10.1002/art.24801
    • Kapoor M, McCann M, Liu SX, Huh K, Denton CP, Abraham DJ, Leask A (2009). Loss of Peroxisome Proliferator-Activated Receptor gamma in Mouse Fibroblasts Results in Increased Susceptibility to Bleomycin-Induced Skin Fibrosis. ARTHRITIS RHEUM, 60(9), 2822 - 2829. doi:10.1002/art.24761
    • Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar V, Hoyles R, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl G (2009). Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.. Arthritis Rheum., 60(7), 2142 - 2155.
    • Shiwen X, Leask A, Abraham DJ, Fonseca C (2009). Endothelin receptor selectivity: evidence from in vitro and pre-clinical models of scleroderma.. Eur J Clin Invest, 39 Suppl 2, 19 - 26. doi:10.1111/j.1365-2362.2009.02117.x
    • Ponticos M, Harvey C, Ikeda T, Abraham D, Bou-Gharios G (2009). JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.. Nucleic Acids Res., 37(16), 5378 - 5389.
    • Abraham DJ, Krieg T, Distler J, Distler O (2009). Overview of pathogenesis of systemic sclerosis.. Rheumatology (Oxford), 48 Suppl 3, iii3 - iii7. doi:10.1093/rheumatology/ken481
    • Chen YL, Leask A, Abraham DJ, Kennedy L, Xu SW, Denton CP, Black CM, Eastwood M (2009). Thrombospondin 1 is a key mediator of TGF beta-mediated cell contractility in systemic sclerosis via a MEK/ERK-dependent mechanism. CLIN EXP RHEUMATOL, 27(3), S83 - S83.
    • Lindahl G, Leoni P, Ponticos M, Xu SW, Renzoni E, Holmes A, Black CM, Denton CP, Abraham DJ (2009). CONSTITUTIVE NUCLEAR ACCUMULATION OF CBF IN SYSTEMIC SCLEROSIS PULMONARY FIBROBLASTS: A PUTATIVE TRANSCRIPTIONAL MECHANISM UNDERLYING THE FIBROTIC PHENOTYPE.
    • Dooley A, Xu SW, Aden N, Tranah T, Desai N, Denton CP, Black CM, Abraham DJ, Bruckdorfer R (2009). MODULATION OF TYPE I COLLAGEN SYNTHESIS AND FIBROBLAST FUNCTION IN SYSTEMIC SCLEROSIS BY THE GREEN TEA ANTIOXIDANT (-)-EPIGALLOCATECHIN-3-GALLATE.
    • Shiwen X, Parapuram S, Pala D, Carter D, Eastwood M, Denton C, Black C, Leask A, Abraham D (2009). TGF-BETA INDUCTION OF THE MYOFIBROBLAST PHENOTYPE REQUIRES TAK-1. RHEUMATOLOGY, 48, I77 - I77.
    • Shiwen X, Rajkumar V, Denton CP, Leask A, Abraham DJ (2009). Pericytes display increased CCN2 expression upon culturing.. J Cell Commun Signal, 3(1), 61 - 64. doi:10.1007/s12079-009-0053-7
    • Denton CP, Khan K, Hoyles RK, Shiwen X, Leoni P, Chen Y, Eastwood M, Abraham DJ (2009). Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.. J Invest Dermatol, 129(1), 194 - 204. doi:10.1038/jid.2008.171
    • Fonseca C, Abraham D, Ponticos M (2009). Neuronal regulators and vascular dysfunction in Raynaud's phenomenon and systemic sclerosis.. Curr Vasc Pharmacol, 7(1), 34 - 39.
    • Xu SW, Liu S, Eastwood M, Sonnylal S, Denton CP, Abraham DJ, Leask A (2009). Rac inhibition reverses the phenotype of fibrotic fibroblasts.. PLoS One, 4(10), e7438 - . doi:10.1371/journal.pone.0007438
    • Shi-wen X, Parapuram SK, Pala D, Chen Y, Carter DE, Eastwood M, Denton CP, Abraham DJ, Leask A (2009). Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts.. Arthritis Rheum, 60(1), 234 - 241. doi:10.1002/art.24223
    • Pimenta D, Haque S, Heetun M, Dashwood M, Shiwen W, Farooqui N, Abraham D, Loizidou M (2009). The Endothelin Axis in Drug Sensitive and Multidrug Resistant Bladder Cancer Cells.
    • Ponticos M, Harvey C, Ikeda T, Abraham D, Bou-Gharios G (2009). JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.. Nucleic Acids Res, 37(16), 5378 - 5389. doi:10.1093/nar/gkp544

    2008

    • Liu SX, Kapoor M, Shi-wen X, Kennedy L, Denton CP, Glogauer M, Abraham DJ, Leask A (2008). Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice. ARTHRITIS RHEUM, 58(7), 2189 - 2195. doi:10.1002/art.23595
    • Aden N, Xu SW, Nuttall A, Denton CP, Black CM, Abraham DJ, Stratton RJ (2008). Role of epidermis in scleroderma.
    • de Winter P, Leoni P, Abraham D (2008). Connective tissue growth factor: structure-function relationships of a mosaic, multifunctional protein.. Growth Factors, 26(2), 80 - 91. doi:10.1080/08977190802025602
    • Abraham DJ (2008). Endothelin receptor selectivity: Evidence from in vitro and pre-clinical SSc models. EUR J CLIN INVEST, 38, 58 - 58.
    • Hoyles RK, Khan K, Shiwen X, Howat SL, Lindahl GE, Leoni P, du Bois RM, Wells AU, Black CM, Abraham DJ, Denton CP (2008). Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis - Exaggerated response to alveolar epithelial injury in a novel mouse model. ARTHRITIS RHEUM, 58(4), 1175 - 1188. doi:10.1002/art.23379
    • Hoyles RK, Khan K, Xu SW, Howat S, Wells AU, Abraham DJ, Black CM, Denton CP (2008). Inducible disruption of TGF signalling in resident lung fibroblasts prevents experimental fibrosis.
    • Shi-Wen X, Leask A, Abraham D (2008). Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis.. Cytokine Growth Factor Rev, 19(2), 133 - 144. doi:10.1016/j.cytogfr.2008.01.002
    • Chen Y, Leask A, Abraham DJ, Pala D, Shiwen X, Khan K, Liu S, Carter DE, Wilcox-Adelman S, Goetinck P, Denton CP, Black CM, Pitsillides AA, Sarraf CE, Eastwood M (2008). Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.. Arthritis Rheum, 58(2), 577 - 585. doi:10.1002/art.23146
    • Fonseca C, Pantelidis P, Abraham D (2008). CTGF polymorphism associated with systemic sclerosis - Reply. NEW ENGLAND JOURNAL OF MEDICINE, 358(3), 309 - 309.
    • Tsui JCS, Baker D (2008). Current State of Medical Therapies for Peripheral Vascular Disease. In Abraham D, Handler C, Dashwood M, Coghlan G (Ed.), Vascular Complications in Human Disease: Mechanisms and Consequences (pp. 139 - 149). : Springer-Verlag. doi:10.1007/978-1-84628-919-4_11
    • Loizidou M (2008). Endothelin-1 promoting actions in the growth and angiogenesis of solid cancers.. In Black C, Dashwood M, Abraham D (Ed.), Vascular complications of human disease: Mechanisms and consequences (pp. 187 - 196). : .
    • Ho TK, Xu S, Leoni P, Aden N, DiSalvo C, Walesby R, Black CM, Abraham DJ, Hamilton G, Baker D (2008). Increased SDF-1alpha and CXCR4 but not SDF-1beta expression in human critical limb ischaemia.
    • Ho TK, Xu S, Leoni P, Abraham DJB, C M Hamilton G, Baker D (2008). The Angiogenic effects of CXCL12 variants and the expressions of CXCL12 variants and CXCR4 in human critical limb ischaemia..
    • (2008). Vascular Complications in Human Disease: Mechanisms and Consequences. doi:10.1007/978-1-84628-919-4
    • Baker D, Denton C (2008). Vascular Complications of Systemic Sclerosis: A Molecular Perspective. In Abraham D, Handler C, Dashwood M, Coghlan G (Ed.), Vascular Complications in Human Disease: Mechanisms and Consequences (pp. 119 - 127). : Springer-Verlag. doi:10.1007/978-1-84628-919-4_9
    • Aden N, Shiwen X, Aden D, Black C, Nuttall A, Denton CP, Leask A, Abraham D, Stratton R (2008). Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer.. Rheumatology (Oxford), 47(12), 1754 - 1760. doi:10.1093/rheumatology/ken370
    • Abraham D (2008). Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?. Rheumatology (Oxford), 47 Suppl 5, v8 - v9. doi:10.1093/rheumatology/ken278
    • Abraham D, Dashwood M (2008). Endothelin--role in vascular disease.. Rheumatology (Oxford), 47 Suppl 5, v23 - v24. doi:10.1093/rheumatology/ken282
    • Leask A, Shi-wen X, Khan K, Chen Y, Holmes A, Eastwood M, Denton CP, Black CM, Abraham DJ (2008). Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function.. J Cell Sci, 121(20), 3459 - 3467.
    • Abraham DJ (2008). TGF-beta and smad signalling in fibrosis. EXP DERMATOL, 17(10), 887 - 890.
    • Khan K, Hoyles RK, Shiwen X, Howat S, Abraham DJ, Denton CP (2008). Conditional post-natal deletion of T beta RII defines a pivotal role for resident fibroblasts in the fibrotic response to lung injury.
    • Khan K, Hoyles RK, Xu SW, Abraham DJ, Denton CP (2008). Disruption of TGFbeta signalling in dermal fibroblasts delays skin wound healing and reduces fibrocyte recruitment.
    • Howat SL, Renzoni EA, Shi-Wen X, Black CM, Leask A, Abraham DJ, Pearson JD (2008). Upregulation of Id1 and Id3 expression in lung fibrosis.

    2007

    • Shi-wen X, Kennedy L, Renzoni EA, Bou-Gharios G, du Bois RM, Black CM, Denton CP, Abraham DJ, Leask A (2007). Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.. Arthritis Rheum, 56(12), 4189 - 4194. doi:10.1002/art.23134
    • Abraham D, Distler O (2007). How does endothelial cell injury start? The role of endothelin in systemic sclerosis.. Arthritis Res Ther, 9 Suppl 2, S2 - . doi:10.1186/ar2186
    • Kennedy L, Liu S, Xu SW, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A (2007). CCN2 is necessary for the function of mouse embryonic fibroblasts (vol 313, pg 952, 2007). EXP CELL RES, 313(16), 3671 - 3671. doi:10.1016/j.yexcr.2007.06.016
    • Xu SW, Renzoni EA, Kennedy L, Howat S, Chen YL, Pearson JD, Bou-Gharios G, Dashwood MR, du Bois RM, Black CM, Denton CP, Abraham DJ, Leask A (2007). Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. MATRIX BIOL, 26(8), 625 - 632. doi:10.1016/j.matbio.2007.06.003
    • Fonseca C, Lindahl G, Ponticos M, Sestini P, Renzoni EA, Spagnolo P, Pantelidis P, Leoni P, Holmes AM, McHugh N, Stock CJ, Shi-Wen X, Denton CP, Black C, Welsh KI, du Bois RM, Abraham DJ (2007). A polymorphism in the CTGF promoter region associated with systemic sclerosis. New England Journal of Medicine, 357(12), 1210 - 1220.
    • Kennedy L, Liu S, Shi-Wen X, Chen Y, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A (2007). The contribution of connective tissue growth factor (CTGF, CCN2) to fibroblast biology.
    • Dooley A, Gao BR, Xu SW, Abraham DJ, Black CM, Jacobs M, Bruckdorfer KR (2007). Effect of nitric oxide and peroxynitrite on type I collagen synthesis in normal and scleroderma dermal fibroblasts. FREE RADICAL BIO MED, 43(2), 253 - 264. doi:10.1016/j.freeradbiomed.2007.04.017
    • Leask A, Shi-Wen X, Black CM, Abraham DJ (2007). Protein kinase c epsilon is required for cutaneous wound closure and myofibroblast formation.
    • Liu SX, Xu S, Kennedy L, Pala D, Chen Y, Eastwood M, Carter DE, Black CM, Abraham DJ, Leask A (2007). FAK is required for TGF beta-induced JNK phosphorylation in fibroblasts: Implications for acquisition of a matrix-remodeling phenotype. MOL BIOL CELL, 18(6), 2169 - 2178. doi:10.1091/mbc.E06-12-1121
    • Abraham DJ, Eckes B, Rajkumar V, Krieg T (2007). New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma.. Curr Rheumatol Rep, 9(2), 136 - 143.
    • Khan K, Leoni P, Hoyles RK, Shiwen X, Abraham DJ, Denton CP (2007). Constitutive activation of p42/44 MAP Kinase signalling in mice with fibroblast-specific deletion of TRII.
    • Shiwen X, Liu S, Kennedy L, Black CM, Denton CP, Least A, Abraham DJ (2007). Focal adhesion kinase is necessary for pro-fibrotic gene expression in normal and scleroderma fibroblasts.
    • Kennedy L, Liu SX, Xu SW, Chen YL, Eastwood M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A (2007). CCN2 is necessary for the function of mouse embryonic fibroblasts. EXP CELL RES, 313(5), 952 - 964. doi:10.1016/j.yexcr.2006.12.006
    • Varga J, Abraham D (2007). Systemic sclerosis: a prototypic multisystem fibrotic disorder. JOURNAL OF CLINICAL INVESTIGATION, 117(3), 557 - 567. doi:10.1172/JCI31139
    • Dashwood MR, Dooley A, Shi-Wen X, Abraham DJ, Souza DS (2007). Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?. J Vasc Res, 44(3), 175 - 181. doi:10.1159/000099833
    • Ho TK, Griffiths M, Dashwood M, Stratton R, Black CM, Abraham DJ, Hamilton G, Baker D (2007). Endothelin-1 promotes proliferation and angiogenesis via the ETB receptor.
    • Loizidou M, Hoosein M, Knowles J, Xu S, Grigoriades A, Dashwood M, Abraham D, Taylor I (2007). ET-1 promotes desmoplasia in human colorectal fibroblasts.
    • Krieg T, Abraham D, Lafyatis R (2007). Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions. doi:10.1186/ar2188
    • Deleuran B, Abraham DJ (2007). Possible implication of the effector CD4(+) T-cell subpopulation T(H)17 in the pathogenesis of systemic scleroderma. NAT CLIN PRACT RHEUM, 3(12), 682 - 683. doi:10.1038/ncprheum0618

    2006

    • Leask A, Kennedy L, Shi-Wen X, Carter DE, Lyons KM, Black CM, Abraham DJ (2006). CTGF(CCN2) is essential for fibroblast function. doi:10.1016/j.matbio.2006.08.235
    • Ho TK, Xu S, Abraham DJ, Black CM, Baker D (2006). The chemokine stromal-derived factor-1 (SDF-1/CXCL12) beta is the more potent variant in human microvascular cell survival and proliferation.
    • Hoyles RK, Khan K, Shiwen X, Lindahl GE, Garcia P, Wells AU, Black CM, Abraham DJ, Denton CP (2006). Alveolar epithelial cell injury triggers lung fibrosis in a mouse model of scleroderma..
    • Fonseca C, Renzoni E, Sestini P, Pantelidis P, Lagan A, Bunn C, McHugh N, Welsh KI, Du Bois RM, Denton CP, Black C, Abraham D (2006). Endothelin axis polymorphisms in patients with scleroderma. Arthritis and Rheumatism, 54(9), 3034 - 3042.
    • Xu SW, Rodriguez-Pascual F, Lamas S, Holmes A, Howat S, Pearson JD, Dashwood MR, du Bois RM, Denton CP, Black CM, Abraham DJ, Leask A (2006). Constitutive ALKS-independent C-jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: Evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. MOL CELL BIOL, 26(14), 5518 - 5527. doi:10.1128/MCB.00625-06
    • Leask A, Abraham DJ (2006). All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J CELL SCI, 119(23), 4803 - 4810. doi:10.1242/jcs.03270
    • Hoyles RK, Khan K, Shiwen X, Lindahl GE, Garcia P, Wells AU, Black CM, Abraham DJ, Denton CP (2006). Perturbed transforming growth factor beta signalling in fibroblasts increases the susceptibility of alveolar epithelial cells to injury in a novel mouse model of systemic sclerosis.
    • Rajkumar VS, Shiwen X, Bostrom M, Leoni P, Muddle J, Ivarsson M, Gerdin B, Denton CP, Bou-Gharios G, Black CM, Abraham DJ (2006). Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. American Journal Of Pathology, 169(6), 2254 - 2265. doi:10.2353/ajpath.2006.060196
    • Dooley A, Gao B, Bradley N, Abraham DJ, Black CM, Jacobs M, Bruckdorfer KR (2006). Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine.. Rheumatology, 45(6), 676 - 684.
    • Menon RP, Menon MR, Shi-Wen X, Renzoni E, Bou-Gharios G, Black CM, Abraham DJ (2006). Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1.. Exp Cell Res, 312(9), 1463 - 1474. doi:10.1016/j.yexcr.2006.01.011
    • Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A (2006). CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.. J Biol Chem, 281(16), 10715 - 10726. doi:10.1074/jbc.M511343200
    • Ponticos M, Holmes AM, Fonseca C, Bou-Gharios G, Denton CP, Black CM, Abraham DJ (2006). A novel TGF-beta response element located in the human collagen type I alpha 2 far upstream enhancer is SMAD-independent.
    • Shiwen X, Leask A, Renzoni E, Howat S, Bou-Gharios G, Pearson J, du Bois R, Denton CP, Abraham DJ, Black CM (2006). Bosentan attenuates the profibrotic gene expression profile of lung fibroblasts in scleroderma.
    • Chen Y, Shi-wen X, Eastwood M, Black CM, Denton CP, Leask A, Abraham DJ (2006). Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.. Arthritis and Rheumatism, 54(4), 1309 - 1316.
    • Denton CP, Khan K, Leoni P, Shiwen X, Abraham DJ, Black CM (2006). Key features of late-stage systemic sclerosis are replicated through conditional deletion of the type II TGF beta receptor in fibroblasts.
    • Hoyles RK, Shiwen X, Lindahl GE, Khan K, Abraham DJ, Black CM, Denton CP (2006). Lung fibroblast gene expression and fibroblast - Alveolar epithelial cell cross-talk in a transgenic mouse model of systemic sclerosis.
    • Leask A, Kennedy L, van Beek J, Chen Y, Shi-Wen X, Denton CP, Abraham DJ, Black CM (2006). Matrix contraction by scleroderma fibroblasts requires TGF beta receptor ALK5, ras/MEK/ERK and syndecan 4.
    • Aden NH, Shiwen X, Denton CP, Black CM, Abraham DJ, Stratton RJ (2006). Proteomic studies of scleroderma lesional skin show delayed keratinocyte maturation.
    • Leask A, Kennedy L, Chen YL, Shi-Wen X, Wilcox-Adelman S, Goetinck P, Black CM, Abraham DJ (2006). Matrix contraction by dermal fibroblasts requires syndecan 4: Insights into pathological scarring in chronic fibrotic disease.
    • Denton CP, Black CM, Abraham DJ (2006). Mechanisms and consequences of fibrosis in systemic sclerosis.. Nat Clin Pract Rheumatol, 2(3), 134 - 144. doi:10.1038/ncprheum0115
    • Waters CE, Xu SW, Denton CP, Abraham DJ, Pearson JD (2006). Signaling pathways regulating intercellular adhesion molecule 1 expression by endothelin 1 - Comparison with interleukin-1 beta in normal and scleroderma dermal fibroblasts. ARTHRITIS RHEUM, 54(2), 649 - 660. doi:10.1002/art.21572
    • Ho TK, Shiwen X, DiSalvo C, Walesby RK, Black CM, Abraham DJ, Baker D (2006). Angiogenic roles of stromal-derived factor-1(SDF-1/CXCL12) variants and in-vivo CXCR4 expression in microvessels of human critical limb ischaemia..
    • Ho TK, Griffiths M, Stratton R, Black CMA, D J B, D (2006). Endothelin-1 promotes proliferation and angiogenesis in cultured endothelial cells via the ETB receptor.
    • Knowles J, Loizidou M, Dashwood M, Abraham D, Xu S, Taylor I (2006). Endothelin-1 stimulates colorectal cancer adjacent-fibroblasts. European Journal of Surgical Oncology, 32, 54 - .
    • Ho TK, Abraham DJ, Black CM, Baker D (2006). Hypoxia-Inducible Factor 1 in Lower Limb Ischemia.. Vascular, 14(6), 321 - 327.
    • Ho TK, Rajkumar V, Khan K, DiSalvo C, Walesby RK, Black CMA, D J B, D (2006). Increased angiogenic response but deficient arteriolization and abnormal microvessel ultrastructure in human critical limb ischaemia..
    • Ho TK, Rajkumar V, Ponticos M, Leoni P, Black DCM, Abraham DJ, Baker DM (2006). Increased endogenous angiogenic response and hypoxia-inducible factor-1 alpha in human critical limb ischemia. Journal of Vascular Surgery, 43(1), 125 - 133.
    • Ho TK, Rajkumar V, Ponticos M, Garcia P, Khan K, Hart C, DiSalvo C, Walesby RK, Abraham DJ, Black C, Baker D (2006). Increased hypoxia inducible factor-1alpha and localisation of erythropoietin in human critical limb ischaemia.
    • Ho TK, Rajkumar V, Black CM, Abraham DJ, Baker DM (2006). Increased angiogenic response but deficient arteriolization and abnormal microvessel ultrastructure in critical leg ischaemia. British Journal Of Surgery, 93, 1368 - 1376.

    2005

    • Carulli MT, Ong VH, Ponticos M, Shiwen X, Abraham DJ, Black CM, Denton CP (2005). Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation.. Arthritis Rheum, 52(12), 3772 - 3782. doi:10.1002/art.21396
    • Dziadzio M, Smith RE, Abraham DJ, Black CM, Denton CP (2005). Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score.. Rheumatology (Oxford), 44(12), 1518 - 1524. doi:10.1093/rheumatology/kei088
    • Chen Y, Shi-Wen X, van Beek J, Kennedy L, McLeod M, Renzoni EA, Bou-Gharios G, Wilcox-Adelman S, Goetinck PF, Eastwood M, Black CM, Abraham DJ, Leask A (2005). Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.. Am J Pathol, 167(6), 1699 - 1711.
    • Abraham DJ, Varga J (2005). Scleroderma: from cell and molecular mechanisms to disease models.. Trends Immunol, 26(11), 587 - 595. doi:10.1016/j.it.2005.09.004
    • Abraham D, Ponticos M, Nagase H (2005). Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases.. Curr Vasc Pharmacol, 3(4), 369 - 379.
    • Leask A, Xu SW, Renzoni EA, Bou-Gharios G, du Bois RM, Abraham DJ, Black CM (2005). Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma..
    • Denton CP, Khan K, Leoni P, Xu SW, Abraham DJ, Black CM (2005). Conditional fibroblast-specific deletion of type 2 transforming growth factor beta receptor replicates digital contractures of late-stage scleroderma..
    • Dashwood MR, Savage K, Dooley A, Shi-Wen X, Abraham DJ, Souza DS (2005). Effect of vein graft harvesting on endothelial nitric oxide synthase and nitric oxide production.. Ann Thorac Surg, 80(3), 939 - 944. doi:10.1016/j.athoracsur.2005.03.042
    • Sabetkar M, Holmes A, Rajkumar V, Xu SW, Lyons KM, Bruckdorfer RK, Leask A, Abraham DJ, Black CM (2005). The role of CCN2 in tissue remodelling: Impaired migration of CCN2-deficient mouse embryonic fibroblasts..
    • Dziadzio M, Usinger W, Leask A, Abraham D, Black CM, Denton C, Stratton R (2005). N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma.. Quarterly Journal of Medicine, 98(7), 485 - 492.
    • Dashwood M, Loesch A, Dooley A, Shi-Wen X, Abraham D, Johansson B, Souza DSR (2005). Coronary artery bypass surgery (CABG), vein graft failure and nitric oxide (NO)..
    • Fisher I, Abraham D, Bouri K, Hoffman EP, Muntoni F, Morgan J (2005). Prednisolone-induced changes in dystrophic skeletal muscle. FASEB J, 19(7), 834 - 836.
    • Denton CP, Lindahl GE, Khan K, Shiwen X, Ong VH, Gaspar NJ, Lazaridis K, Edwards DR, Leask A, Eastwood M, Leoni P, Renzoni EA, Bou Gharios G, Abraham DJ, Black CM (2005). Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).. Journal of Biological Chemistry, 280(16), 16053 - 16065. doi:10.1074/jbc.M413134200
    • Carulli MT, Ong VH, Abraham DJ, Coghlan GJ, Black CM, Denton CP (2005). Evaluation of CCL2 as a potential biomarker of pulmonary vascular disease in limited cutaneous systemic sclerosis.
    • Ho TK, Rajkumar V, Black C, Abraham D, Baker D (2005). Critical limb ischaemia classification and therapeutic angiogenesis,. International Journal of Angiology, 14, 49 - 59.
    • Ho TK, Abraham DJ, Black CM, Rajkumar V, DiSalvo C, Walesby RK, Hart C, Baker DM (2005). Increased hypoxia inducible factor-1alpha expression and angiogenesis in critical limb ischaemia in human. British Journal of Surgery, 92, 81 - 81.
    • Rajkumar VS, Howell K, Csiszar K, Denton CP, Black CM, Abraham DJ (2005). Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis.. Arthritis Res Ther, 7(5), R1113 - R1123. doi:10.1186/ar1790

    2004

    • Ponticos M, Abraham D, Alexakis C, Lu QL, Black C, Partridge T, Bou-Gharios G (2004). Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.. Matrix Biology, Feb; 22(8), 619 - 628.
    • Dziadzio M, Smith RE, Abraham DJ, Stratton RJ, Gabrielli A, Black CM, Denton CP (2004). Serological assessment of type I collagen burden in scleroderma spectrum disorders: a systematic review.. Clinical and Experimental Rheumatology, 22(3), 356 - 367.
    • Lindahl GE, Shiwen X, Chambers RC, Denton CP, Abraham DJ, Black CM, Laurent GJ (2004). DNA BINDING-ACTIVITY OF CCAAT-BINDING FACTOR (CBF) IS STRONGLY ENHANCED IN ACTIVATED LUNG FIBROBLASTS FROM PATENTS WITH SYSTEMIC SCLEROSIS. RHEUMATOLOGY, 43, 98 - 99.
    • Leask A, Abraham DJ (2004). TGF-beta signaling and the fibrotic response.. FASEB J, 18(7), 816 - 827. doi:10.1096/fj.03-1273rev
    • Leask A, Denton CP, Abraham DJ (2004). Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.. J Invest Dermatol, 122(1), 1 - 6. doi:10.1046/j.0022-202X.2003.22133.x
    • Chen Y, Abraham DJ, Shi-Wen X, Pearson JD, Black CM, Lyons KM, Leask A (2004). CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.. Molecular Biology of the Cell, 15(12), 5635 - 5646.
    • Renzoni EA, Abraham DJ, Howat S, Shi-Wen X, Sestini P, Bou-Gharios G, Wells AU, Veeraraghavan S, Nicholson AG, Denton CP, Leask A, Pearson JD, Black CM, Welsh KI, du Bois RM (2004). Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.. Respiratory Research, 5(1), 24 - .
    • Ponticos M, Taguri N, Holmes AM, Abraham DJ, Black CM (2004). TGF-ss-producing T cells in systemic sclerosis.
    • Holmes AM, Howat S, Xu SW, Leask A, Ponticos M, Pearson J, Abraham DJ, Black CM (2004). Transcriptional profiling of the scleroderma fibroblast: Evidence of a dysregulated response to TGF ss.
    • Ponticos M, Partridge T, Black CM, Abraham DJ, Bou-Gharios G (2004). Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.. Molecular and Cellular Biology, 24(14), 6151 - 6161.
    • Xu SW, Chen YL, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, Leask A, Abraham DJ (2004). Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Molecular Biology of the Cell, 15(6), 2707 - 2719. doi:10.1091/mbc.E03-12-0902
    • Bou-Gharios G, Ponticos M, Rajkumar V, Abraham D (2004). Extra-cellular matrix in vascular networks.. Cell Prolif, 37(3), 207 - 220. doi:10.1111/j.1365-2184.2004.00306.x
    • Denton CP, Abraham DJ (2004). Transgenic analysis of scleroderma: understanding key pathogenic events in vivo.. Autoimmun Rev, 3(4), 285 - 293. doi:10.1016/j.autrev.2003.10.003
    • Xu SW, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, Leask A, Abraham DJ (2004). Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.. Journal of Biological Chemistry, 279(22), 23098 - 23103. doi:10.1074/jbc.M311430200
    • Xu SW, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, Leask A, Abraham DJ (2004). Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.. J Biol Chem, 279(22), 23098 - 23103. doi:10.1074/jbc.M311430200
    • Holmes AM, Shi-Wen X, Black CM, Abraham DJ (2004). DYSREGULATION OF THE EXPRESSION OF TGF beta ACCESSORY RECEPTORS IN THE SSC FIBROBLAST. RHEUMATOLOGY, 43, 99 - 100.

    2003

    • Denton CP, Zheng B, Evans LA, Shi-wen X, Ong VH, Fisher I, Lazaridis K, Abraham DJ, Black CM, de Crombrugghe B (2003). Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice. Journal of Biological Chemistry, 278(27), 25109 - 25119. doi:10.1074/jbc.M300636200
    • van der Slot AJ, Zuurmond AM, Bardoel AF, Wijmenga C, Pruijs HE, Sillence DO, Brinckmann J, Abraham DJ, Black CM, Verzijl N, DeGroot J, Hanemaaijer R, TeKoppele JM, Huizinga TW, Bank RA (2003). Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. Journal of Biological Chemistry, 278(42), 40967 - 40972.
    • Holmes A, Abraham DJ, Chen Y, Denton C, Shi-wen X, Black CM, Leask A (2003). Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1. Journal of Biological Chemistry, 278(43), 41728 - 41733.
    • Leask A, Abraham DJ (2003). The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology.. Biochem Cell Biol, 81(6), 355 - 363. doi:10.1139/o03-069
    • Ponticos M, Holmes AM, Rajkumar V, Wen XS, Leask A, Abraham DJ, Black CM (2003). Connective tissue growth factor (CTGF) mediates extracellular matrix deposition in bleomycin-induced lung fibrosis via the MEK/ERK signaling pathways..
    • Leask A, Holmes A, Black CM, Abraham DJ (2003). Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. Journal of Biological Chemistry, 278(15), 13008 - 13015. doi:10.1074/jbc.M210366200
    • Ong VH, Evans LA, Shiwen X, Fisher IB, Rajkumar V, Abraham DJ, Black CM, Denton CP (2003). Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse. Arthritis and Rheumatism, 48(7), 1979 - 1991. doi:10.1002/art.11164

    2002

    • Stratton R, Rajkumar V, Ponticos M, Nichols B, Shiwen X, Black CM, Abraham DJ, Leask A (2002). Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway. The FASEB Journal, 16(14), 1949 - 1951.
    • Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, Leask A (2002). CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney International, 62(4), 1149 - 1159.
    • Muntoni F, Fisher I, Morgan JE, Abraham D (2002). Steroids in Duchenne muscular dystrophy: from clinical trials to genomic research. Neuromuscul.Disord, 12 Suppl 1, S162 - S165.
    • Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-wen X, Chen Y, Venstrom K, Dou X, Ponticos M, Black C, Bernabeu C, Jackman JK, Findell PR, Connolly MK (2002). Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis and Rheumatism, 46(7), 1857 - 1865.
    • Griffiths N, Stratton R, Dashwood M, Tsui J, Abraham D, Black C, Baker D (2002). Endothelin-1 promotes angiogenesis in human microvascular endothelial cells acting in synergy with VEGF and via the ET(B) receptor.
    • Leask A, Holmes A, Abraham DJ (2002). Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Current Rheumatology Reports, 4(2), 136 - 142.
    • Leask A, Sa S, Chen YJ, Holmes A, Xu SW, Stratton R, Black C, Abraham D (2002). Connective tissue growth factor (CTGF) and fibrosis. Molecular Biology of the Cell, 12, 2538 - .
    • De Val S, Ponticos M, Antoniv TT, Wells DJ, Abraham D, Partridge T, Bou-Gharios G (2002). Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer. Journal of Biological Chemistry, 277(11), 9286 - 9292.
    • Morgan JE, Gross JG, Pagel CN, Beauchamp JR, Fassati A, Thrasher AJ, Di Santo JP, Fisher IB, Shiwen X, Abraham DJ, Partridge TA (2002). Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site. The Journal of Cell Biology, 157(4), 693 - 702. doi:10.1083/jcb.200108047

    2001

    • Leask A, Sa S, Holmes A, Shiwen X, Black CM, Abraham DJ (2001). The control of ccn2*(ctgf) gene expression in normal and scleroderma fibroblasts. Molecular Pathology, 54(3), 180 - 183.
    • Denton CP, Abraham DJ (2001). Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis. Current Opinion in Rheumatology, 13(6), 505 - 511.
    • Stratton R, Shiwen X, Martini G, Holmes A, Leask A, Haberberger T, Martin GR, Black CM, Abraham D (2001). Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. Journal of Clinical Investigation, 108(2), 241 - 250.
    • Stratton R, Xu SW, Martini G, Holmes A, Leask A, Haberberger T, Martin GR, Black CM, Abraham D (2001). Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. Journal of Clinical Investigation, 108(2), 241 - 250.
    • Leung KY, Wait R, Welson SY, Yan JX, Abraham DJ, Black CM, Pearson JD, Dunn MJ (2001). A reference map of human lung MRC-5 fibroblast proteins using immobilized pH gradient-isoelectric focusing-based two-dimensional electrophoresis. Proteomics, 1(6), 787 - 794.
    • Holmes A, Abraham DJ, Sa S, Shiwen X, Black CM, Leask A (2001). CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. Journal of Biological Chemistry, 276(14), 10594 - 10601.
    • Denton CP, Shiwen X, Zheng B, Rajkumar V, Abraham DJ, de Crombrugghe R, Black CM (2001). A fibrotic phenotype is induced by expression of a mutant human TGF beta receptor in transgenic mice. RHEUMATOLOGY, 40, 78 - 79.
    • Holmes AM, Leask A, Shi-wen X, Sa S, Xu Y, Martin GR, Abraham DJ, Black CM (2001). Control of fibroblast extracellular matrix production by CTGF: regulation by TGF beta, TNF-alpha and IL-1. RHEUMATOLOGY, 40, 13 - 13.
    • Shi-wen X, Denton CP, Dashwood MR, Holmes AM, Bou-Gharios G, Pearson JD, Black CM, Abraham DJ (2001). Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. Journal of Investigative Dermatology, 116(3), 417 - 425.
    • Xu SW, Denton CP, Dashwood MR, Holmes AM, Bou-Gharios G, Pearson JD, Black CM, Abraham DJ (2001). Fibroblast matrix gene expression and connective tissue remodeling: Role of endothelin-1. J INVEST DERMATOL, 116(3), 417 - 425.
    • Leask A, Sa S, Chen YJ, Holmes A, Xu SW, Stratton R, Black C, Abraham D (2001). Connective tissue growth factor (CTGF) and fibrosis. Molecular Biology of the Cell, 12, 2538 - .
    • Fisher I, Morgan J, Abraham D, Brittan H, Dunn M, Muntoni F (2001). Glucocorticoid-induced changes in the gene expression of dystrophic mouse muscle. Neuromuscular Disorders, 11(6-7), 663 - 663.
    • Wollheim FA, Denton CP, Abraham DJ (2001). Sixth international workshop on scleroderma research, Oxford, UK, 30 July - 2 August 2000. Arthritis Research and Therapy, 3(1), 34 - 40. doi:10.1186/ar137

    2000

    • Abraham DJ, Shiwen X, Black CM, Sa S, Xu Y, Leask A (2000). Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. Journal of Biological Chemistry, 275(20), 15220 - 15225.
    • Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM, Martin GR, Black CM, Abraham DJ (2000). Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. Experimental Cell Research, 259(1), 213 - 224.
    • Gao B, Abraham D, Black CM, Jacobs M, Bruckdorfer KR (2000). Effects of nitric oxide and peroxynitrite on collagen biosynthesis by normal and scleroderma skin fibroblasts. Nitric Oxide, 4(3), 287 - 288.

    1999

    • Fonseca C, Abraham D, Black CM (1999). Lung fibrosis. Springer Semin.Immunopathol., 21(4), 453 - 474.
    • Gao B, Cash D, Abraham D, Black C, Bruckdorfer KR, Jacobs M (1999). Sera from patients with primary Raynaud's disease and limited scleroderma alter vascular responsiveness in the rabbit aorta.

    1998

    • Shi-wen X, Denton CP, Holmes A, Dashwood MR, Abraham DJ, Black CM (1998). Endothelins: Effect on matrix biosynthesis and proliferation in normal and scleroderma fibroblasts. Journal of Cardiovascular Pharmacology, 31, - .
    • Shi-wen X, Denton CP, Dashwood MR, Abraham DJ, Black CM (1998). Endothelins-1 regulation of intracellular adhesion molecule-1 expression in normal and sclerodermal fibroblasts. Journal of Cardiovascular Pharmacology, 31, - .

    1997

    • Abraham DJ, Vancheesaran R, Dashwood MR, Rajkumar VS, Pantelides P, Shi-wen X, Du Bois RM, Black CM (1997). Increased levels of endothelin-1 and differential endothelin Type A and B receptor expression in scleroderma-associated fibrotic lung disease. American Journal of Pathology, 151(3), 831 - 841.

    1995

    • Shiwen X, Vancheeswaran R, Bou-Gharios G, O'Hare MJ, Olsen I, Abraham D, Black C (1995). Scleroderma-derived human fibroblasts retain abnormal phenotypic and functional characteristics following retroviral transduction with the SV40 tsT antigen. Experimental Cell Research, 220(2), 407 - 414.
    • Xu SVRB-GGOMJOIADBC (1995). Scleroderma-derived human fibroblasts retain abnormal phenotypic and functional characteristics following retroviral transduction with the SV40 tsT antigen.. Exp Cell Res., 220(2), 407 - 414.

    1994

    • Shi-Wen XPMVRMJHDBCOI (1994). Expression and shedding of intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 by normal and scleroderma fibroblasts.. Arthritis Rheum., 37(11), 1689 - 1697.
    • Shi-Wen X, Panesar M, Vancheeswaran R, Mason J, Haskard D, Black C, Olsen I, Abraham D (1994). Expression and shedding of intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 by normal and scleroderma fibroblasts. Effects of interferon-γ, tumour necrosis factor α, and estrogen. Arthritis and Rheumatism, 37(11), 1689 - 1697.
    • Abraham DB-GGTGSHOI (1994). Regulation of CD2-mediated heterotypic interactions of murine T lymphocytes.. Cell Immunol, 156(2), 342 - 356.

    1993

    • Olsen I, Bou-Gharios G, Abraham D, Chain B (1993). Lysosomal enzyme transfer from different types of lymphoid cell. Experimental Cell Research, 209(1), 133 - 139.
    • Bou-Gharios G, Abraham D, Olsen I (1993). Lysosomal storage diseases: mechanisms of enzyme replacement therapy. Histochemical Journal, 25(9), 593 - 605.
    • Olsen I, Adams G, Watson G, Chain B, Abraham D (1993). Multi-level regulation of lysosomal gene expression in lymphocytes. Biochemical and Biophysical Research Communications, 195(1), 327 - 335.

    1992

    • Beauchamp JRADJB-GGPTAOI (1992). Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture.. Am J Pathol., 140, 387 - 401.

    1991

    • Bou-Gharios GMJPTADOI (1991). Contact-dependent transfer of a lysosomal enzyme from lymphocytes to fibroblasts.. J Cell Sci., 100(3), 443 - 449.
    • Abraham DLSMAP-ZCPTHKJHOI (1991). Expression and function of surface antigens on scleroderma fibroblasts. Arthritis Rheum, 34(9), 1164 - 1172.

    1988

    • Olsen IADSIB-GGMHWB (1988). Cell contact induces the synthesis of a lysosomal enzyme precursor in lymphocytes and its direct transfer to fibroblasts.. Biochim Biophys Acta., 968(3), 312 - 322.
    • Abraham DMHWBOI (1988). Lymphocytes transfer only the lysosomal form of alpha-D-mannosidase during cell-to-cell contact.. Exp Cell Res, 175(1), 158 - 168.

    1986

    • Abraham DB-GGMHOISRWB (1986). Effects of mitogenic stimulation on lymphocyte alpha-D-mannosidases.. Eur J Cell Biol, 40(2), 167 - 175.
    • Abraham DDPDAOJSRWB (1986). Structural analysis of the major urinary oligosaccharides in feline alpha-mannosidosis.. Biochem J, 233(3), 899 - 904.

    1984

    • Abraham DBWFDAHMEJJLJTOJPACSRWB (1984). The enzymic defect and storage products in canine fucosidosis.. Biochem J, 222(1), 25 - 33.

    1983

    • Abraham DBWFJRDSRWB (1983). The catabolism of mammalian glycoproteins. Comparison of the storage products in bovine, feline and human mannosidosis.. Biochem J, 215(3), 573 - 579.
    • Abraham DJSRWBGDPRDA (1983). Swainsonine affects the processing of glycoproteins in vivo.. FEBS Lett., 163(1), 110 - 113.

    • Abraham DB-GGOISISRWB (). Forms and intracellular distribution of alpha-D-mannosidases in murine liver and spleen.. Int J Biochem, 20(4), 439 - 447.
    • Abraham DMHOIWB (). Direct enzyme transfer from lymphocytes corrects a lysosomal storage disease.. Biochem Biophys Res Commun, 129(2), 417 - 425.