Prof David Linch

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Personal Profile

Name: David Linch Email: david.linch@ucl.ac.uk
Title: Prof Tel:
Department: Research Department of Haematology Fax:
Position: Professor of Clinical Haematology Address: , , ,
Research Domain: Personalised Medicine Web Page:  

Profile

Research Description


Research Activities

Cell signalling through phospholipases, kinases and G-proteins during differentiation and secretion.

The genetics of acute lymphoblastic leukaemia

Education Description

UCL Collaborators

Prof Hans Stauss; Prof Stephen Mackinnon; Prof Ivan Gout; Prof Rosemary Gale; Dr Adele Fielding; Prof Geraint Thomas; Dr Elisabeth Nacheva

External Collaborators

Publications

    2013

    • Cunningham D, Hawkes EA, Jack A, Qian W, Smith P, Mouncey P, Pocock C, Ardeshna KM, Radford JA, McMillan A, Davies J, Turner D, Kruger A, Johnson P, Gambell J, Linch D (2013). Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles. LANCET, 381(9880), 1817 - 1826. doi:10.1016/S0140-6736(13)60313-X
    • Jenkinson S, Koo K, Mansour MR, Goulden N, Vora A, Mitchell C, Wade R, Richards S, Hancock J, Moorman AV, Linch DC, Gale RE (2013). Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial.. Leukemia, 27(1), 41 - 47. doi:10.1038/leu.2012.176

    2012

    • Swerdlow AJ, Cooke R, Bates A, Cunningham D, Falk SJ, Gilson D, Hancock BW, Harris SJ, Horwich A, Hoskin PJ, Linch DC, Lister TA, Lucraft HH, Radford JA, Stevens AM, Syndikus I, Williams MV (2012). Breast cancer risk after supradiaphragmatic radiotherapy for Hodgkin's lymphoma in England and Wales: a National Cohort Study.. J Clin Oncol, 30(22), 2745 - 2752. doi:10.1200/JCO.2011.38.8835
    • Gisselbrecht C, Schmitz N, Mounier N, Singh Gill D, Linch DC, Trneny M, Bosly A, Milpied NJ, Radford J, Ketterer N, Shpilberg O, Dührsen U, Hagberg H, Ma DD, Viardot A, Lowenthal R, Brière J, Salles G, Moskowitz CH, Glass B (2012). Rituximab maintenance therapy after autologous stem-cell transplantation in patients with relapsed CD20(+) diffuse large B-cell lymphoma: final analysis of the collaborative trial in relapsed aggressive lymphoma.. J Clin Oncol, 30(36), 4462 - 4469. doi:10.1200/JCO.2012.41.9416

    2011

    • Peggs KS, Kayani I, Edwards N, Kottaridis P, Goldstone AH, Linch DC, Hough R, Morris EC, Fielding A, Chakraverty R, Thomson KJ, Mackinnon S (2011). Donor lymphocyte infusions modulate relapse risk in mixed chimeras and induce durable salvage in relapsed patients after T-cell-depleted allogeneic transplantation for Hodgkin's lymphoma.. J Clin Oncol, 29(8), 971 - 978. doi:10.1200/JCO.2010.32.1711
    • Hayee B, Antonopoulos A, Murphy EJ, Rahman FZ, Sewell G, Smith BN, McCartney S, Furman M, Hall G, Bloom SL, Haslam SM, Morris HR, Boztug K, Klein C, Winchester B, Pick E, Linch DC, Gale RE, Smith AM, Dell A, Segal AW (2011). G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction.. Glycobiology, 21(7), 914 - 924. doi:10.1093/glycob/cwr023
    • Lowry L, Smith P, Qian W, Falk S, Benstead K, Illidge T, Linch D, Robinson M, Jack A, Hoskin P (2011). Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial.. Radiother Oncol, 100(1), 86 - 92. doi:10.1016/j.radonc.2011.05.013
    • Mohamedbhai SG, Sibson K, Marafioti T, Kayani I, Lowry L, Goldstone AH, Linch DC, Ardeshna KM (2011). Rituximab in combination with CODOX-M/IVAC: a retrospective analysis of 23 cases of non-HIV related B-cell non-Hodgkin lymphoma with proliferation index >95%.. Br J Haematol, 152(2), 175 - 181. doi:10.1111/j.1365-2141.2010.08447.x
    • Swerdlow AJ, Higgins CD, Smith P, Cunningham D, Hancock BW, Horwich A, Hoskin PJ, Lister TA, Radford JA, Rohatiner AZ, Linch DC (2011). Second cancer risk after chemotherapy for Hodgkin's lymphoma: a collaborative British cohort study.. J Clin Oncol, 29(31), 4096 - 4104. doi:10.1200/JCO.2011.34.8268
    • Green CL, Evans CM, Zhao L, Hills RK, Burnett AK, Linch DC, Gale RE (2011). The prognostic significance of IDH2 mutations in AML depends on the location of the mutation.. Blood, 118(2), 409 - 412. doi:10.1182/blood-2010-12-322479

    2010

    • Lambert JR, Bomanji JB, Peggs KS, Thomson KJ, Chakraverty RK, Fielding AK, Kottaridis PD, Roughton M, Morris EC, Goldstone AH, Linch DC, Ell PJ, Mackinnon S (2010). Prognostic role of PET scanning before and after reduced-intensity allogeneic stem cell transplantation for lymphoma.. Blood, 115(14), 2763 - 2768. doi:10.1182/blood-2009-11-255182
    • Stringaris K, Barrett AJ, Hills R, Linch DC, Gale R, Allen C, Garland P, Sargent R, de Lavallade H, Alsuliman A, Khoder A, Gabriel IH, Sekine T, Burnett A, Rezvani K, Apperley JF (2010). A Distinct Signature of Natural Killer Cell MR Gene Frequencies In Secondary AML Compared with De Novo AML and Normal Controls.
    • Lee L, Ahmed SO, Symeonidis A, Linch DC, Goldstone A, Chakraverty R, Mackinnon S, Kottaridis PD (2010). Cardiac toxicity in patients over the age of 60 undergoing autologous stem cell transplantation for lymphoma.
    • Mead AJ, Thomson KJ, Morris EC, Mohamedbhai S, Denovan S, Orti G, Fielding AK, Kottaridis PD, Hough R, Chakraverty R, Linch DC, Mackinnon S, Peggs KS (2010). HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning.. Blood, 115(25), 5147 - 5153. doi:10.1182/blood-2010-01-265413
    • Mead A, Thomson KJ, Morris EC, Mohamedbhai S, Orti G, Chakraverty R, Linch DC, Mackinnon S, Peggs KS (2010). HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced intensity conditioning.
    • Thomson KJ, Morris EC, Milligan D, Parker AN, Hunter AE, Cook G, Bloor AJ, Clark F, Kazmi M, Linch DC, Chakraverty R, Peggs KS, Mackinnon S (2010). T-cell-depleted reduced-intensity transplantation followed by donor leukocyte infusions to promote graft-versus-lymphoma activity results in excellent long-term survival in patients with multiply relapsed follicular lymphoma.. J Clin Oncol, 28(23), 3695 - 3700. doi:10.1200/JCO.2009.26.9100
    • Sellar RS, Corbett EL, D'Sa S, Linch DC, Ardeshna KM (2010). [Therapy of lymph node tuberculosis].. Praxis (Bern 1994), 99(17), 1043 - 1046. doi:10.1024/1661-8157/a000242
    • Ardeseina KM, Qian WD, Smith P, Warden J, Stevens L, Pocock CFE, Miall F, Cunningham D, Davies J, Walewski J, Ferhanoglu AB, Bradstock K, Linch DC (2010). An Intergroup Randomised Trial of Rituximab Versus a Watch and Wait Strategy In Patients with Stage II, III, IV, Asymptomatic, Non-Bulky Follicular Lymphoma (Grades 1, 2 and 3a) A Preliminary Analysis.
    • Green CL, Evans CM, Hills R, Zhao L, Burnett A, Linch DC, Gale R (2010). Younger Adult Acute Myeloid Leukemia (AML) Patients with IDH2 R140 Mutations Have a Significantly Better Prognosis Than Those with Either IDH2 R172 or IDH1 Mutations.
    • Sellar RS, Corbett EL, D'Sa S, Linch DC, Ardeshna KM (2010). Treatment for lymph node tuberculosis.. BMJ, 340, c63 - .
    • Burnett AK, Hills RK, Green C, Jenkinson S, Koo K, Patel Y, Guy C, Gilkes A, Milligan DW, Goldstone AH, Prentice AG, Wheatley K, Linch DC, Gale RE (2010). The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA.. Blood, 115(5), 948 - 956. doi:10.1182/blood-2009-08-236588
    • Linch DC, Yung L, Smith P, Maclennan K, Jack A, Hancock B, Cunningham D, Hoskin P, Qian W, Holte H, Boesen AM, Grigg A, Browett P, Trneny M (2010). Final analysis of the UKLG LY02 trial comparing 6-8 cycles of CHOP with 3 cycles of CHOP followed by a BEAM autograft in patients <65 years with poor prognosis histologically aggressive NHL.. Br J Haematol, 149(2), 237 - 243. doi:10.1111/j.1365-2141.2010.08081.x
    • Sellar RS, Corbett EL, D'Sa S, Linch DC, Ardeshna KM (2010). Lesson of the Week Treatment for lymph node tuberculosis. BRIT MED J, 340, - . doi:10.1136/bmj.c63
    • Green CL, Koo KK, Hills RK, Burnett AK, Linch DC, Gale RE (2010). Prognostic Significance of CEBPA Mutations in a Large Cohort of Younger Adult Patients With Acute Myeloid Leukemia: Impact of Double CEBPA Mutations and the Interaction With FLT3 and NPM1 Mutations. J CLIN ONCOL, 28(16), 2739 - 2747. doi:10.1200/JCO.2009.26.2501
    • Green CL, Evans CM, Hills RK, Burnett AK, Linch DC, Gale RE (2010). The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status.. Blood, 116(15), 2779 - 2782. doi:10.1182/blood-2010-02-270926
    • Gisselbrecht C, Glass B, Mounier N, Singh Gill D, Linch DC, Trneny M, Bosly A, Ketterer N, Shpilberg O, Hagberg H, Ma D, Brière J, Moskowitz CH, Schmitz N (2010). Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era.. J Clin Oncol, 28(27), 4184 - 4190. doi:10.1200/JCO.2010.28.1618
    • Green CL, Evans CM, Hills RK, Burnett AK, Linch DC, Gale RE (2010). The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. BLOOD, 116(15), 2779 - 2782. doi:10.1182/blood-2010-02-270926
    • Philip B, Thomas S, Marin V, Jathoul A, Kopec A, Linch DC, Pule M (2010). A Highly Compact Epitope-Based Marker Suicide Gene for More Convenient and Safer T Cell Adoptive Immunotherapy.
    • Peggs KS, Thomson K, Morris E, Kottaridis P, Hough R, Goldstone A, Fielding A, Ardeshna K, Chakraverty R, Linch DC, Mackinnon S (2010). Donor lymphocyte infusions guided by PET-CT offer durable salvage in relapsed Hodgkin's lymphoma post-allogeneic transplantation.

    2009

    • Green CL, Koo KK, Hills RK, Burnett AK, Linch DC, Gale RE (2009). PROGNOSTIC SIGNIFICANCE OF CEBPA MUTATIONS IN A LARGE COHORT OF YOUNGER ADULT PATIENTS WITH AML: IMPACT OF DOUBLE CEBPA MUTATIONS AND THE INTERACTION WITH FLT3 AND NPM1 MUTATIONS.
    • Bowen D, Groves MJ, Burnett AK, Patel Y, Allen C, Green C, Gale RE, Hills R, Linch DC (2009). TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis.. Leukemia, 23(1), 203 - 206. doi:10.1038/leu.2008.173
    • Lambert JR, Gale RE, Linch DC (2009). The production of JAK2 wild-type platelets is not downregulated in patients with JAK2 V617F mutant-positive essential thrombocythaemia.. Br J Haematol, 145(1), 128 - 130. doi:10.1111/j.1365-2141.2009.07597.x
    • Tosello V, Mansour MR, Barnes K, Paganin M, Sulis ML, Jenkinson S, Allen CG, Gale RE, Linch DC, Palomero T, Real P, Murty V, Yao X, Richards SM, Goldstone A, Rowe J, Basso G, Wiernik PH, Paietta E, Pieters R, Horstmann M, Meijerink JP, Ferrando AA (2009). WT1 mutations in T-ALL.. Blood, 114(5), 1038 - 1045. doi:10.1182/blood-2008-12-192039
    • Mansour MR, Sulis ML, Duke V, Foroni L, Jenkinson S, Koo K, Allen CG, Gale RE, Buck G, Richards S, Paietta E, Rowe JM, Tallman MS, Goldstone AH, Ferrando AA, Linch DC (2009). Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol.. J Clin Oncol, 27(26), 4352 - 4356. doi:10.1200/JCO.2009.22.0996
    • Lambert JR, Everington T, Linch DC, Gale RE (2009). In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm.. Blood, 114(14), 3018 - 3023. doi:10.1182/blood-2009-03-209916
    • Hancock BW, Qian WD, Linch D, Delchier JC, Smith P, Jakupovic I, Burton C, Souhami R, Wotherspoon A, Copie-Bergman C, Capella C, Traulle C, Levy M, Cortelazzo S, Ferreri AJM, Ambrosetti A, Pinotti G, Martinelli G, Vitolo U, Cavalli F, Gisselbrecht C, Zucca E (2009). Chlorambucil versus observation after anti-Helicobacter therapy in gastric MALT lymphomas: results of the international randomised LY03 trial. BRIT J HAEMATOL, 144(3), 367 - 375. doi:10.1111/j.1365-2141.2008.07486.x
    • Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike O, K C, S D, Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJ, Gale RE, Linch DC, Bayford J, Brown L, Quaye M, Kinnon C, Ancliff P, Webb DK, Schmidt M, von KC, Gaspar HB, Thrasher AJ (2009). Insertional mutagenesis combined with acquired somatic mutations causes leukaemogenesis following gene therapy of SCID-X1 patients. Journal of Clinical Investigation, 118(9), 3143 - 3150.
    • Mohamedbhai SG, Lowry L, Goldstone AH, Linch DC, Ardeshna KM (2009). Rituximab in combination with CODOX-M/IVAC: toxicity and efficacy in 17 adults with non-HIV related B-cell non-Hodgkin lymphomas with 495% proliferation index.
    • Thomson KJ, Morris EC, Bloor A, Cook G, Milligan D, Parker A, Clark F, Yung L, Linch DC, Chakraverty R, Peggs KS, Mackinnon S (2009). Favorable long-term survival after reduced-intensity allogeneic transplantation for multiple-relapse aggressive non-Hodgkin's lymphoma.. J Clin Oncol, 27(3), 426 - 432. doi:10.1200/JCO.2008.17.3328
    • Smith BN, Ancliff PJ, Pizzey A, Khwaja A, Linch DC, Gale RE (2009). Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds.. Br J Haematol, 144(5), 762 - 770. doi:10.1111/j.1365-2141.2008.07493.x
    • Lambert J, Linch DC, Gale RE (2009). MULTIPLE JAK2 V617F MUTATIONS ARE PRESENT IN MOST PATIENTS WITH ESSENTIAL THROMBOCYTHAEMIA: A NEW DISEASE PARADIGM.
    • Hoskin PJ, Lowry L, Horwich A, Jack A, Mead B, Hancock BW, Smith P, Qian WD, Patrick P, Popova B, Pettitt A, Cunningham D, Pettengell R, Sweetenham J, Linch D, Johnson PWM (2009). Randomized Comparison of the Stanford V Regimen and ABVD in the Treatment of Advanced Hodgkin's Lymphoma: United Kingdom National Cancer Research Institute Lymphoma Group Study ISRCTN 64141244. doi:10.1200/JCO.2009.23.3239

    2008

    • Gale RE, Green C, Allen C, Mead AJ, Burnett AK, Hills RK, Linch DC (2008). The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.. Blood, 111(5), 2776 - 2784.
    • Mead AJ, Khwaja A, Gale R, Linch DC (2008). FLT3 ITD and TKD Mutations Differ in Their Functional Consequence in Both Cell Line Models and Primary Hematopoietic Cells..
    • Gilleece MH, Pearce R, Linch DC, Wilson M, Towlson K, Mackinnon S, Potter M, Kazmi M, Gribben JG, Marks DI (2008). The outcome of haemopoietic stem cell transplantation in the treatment of lymphoplasmacytic lymphoma in the UK: a British Society Bone Marrow Transplantation study.. Hematology, 13(2), 119 - 127. doi:10.1179/102453308X315915
    • Mead AJ, Gale RE, Kottaridis PD, Matsuda S, Khwaja A, Linch DC (2008). Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication.. Br J Haematol, 141(4), 454 - 460. doi:10.1111/j.1365-2141.2008.07025.x
    • Guy C, Gilkes A, Gale R, Linch DC, Hills R, Burnett AK (2008). The Impact of MN1 Over-Expression on the Outcome of Younger Patients with AML Treated with Intensive Chemotherapy with or without ATRA Therapy.
    • Mackinnon S, Morris EC, Bloor A, Cook G, Milligan D, Parker A, Craddock C, Yung L, Linch DC, Chakraverty RK, Peggs KS, Thomson KJ (2008). Excellent long-term survival following reduced intensity allogeneic transplantation for multiply relapsed follicular lymphoma.
    • Mackinnon S, Morris EC, Bloor A, Cook G, Milligan D, Parker A, Craddock C, Yung L, Linch DC, Chakraverty RK, Peggs KS, Thomson KJ (2008). Favourable long-term survival following reduced intensity allogeneic transplantation for multiply relapsed aggressive non-Hodgkins lymphoma.
    • Thomson KJ, Peggs KS, Smith P, Cavet J, Hunter A, Parker A, Pettengell R, Milligan D, Morris EC, Goldstone AH, Linch DC, Mackinnon S (2008). Superiority of reduced-intensity allogeneic transplantation over conventional treatment for relapse of Hodgkin's lymphoma following autologous stem cell transplantation. BONE MARROW TRANSPL, 41(9), 765 - 770. doi:10.1038/sj.bmt.1705977
    • Green C, Linch DC, Gale RE (2008). Most acute myeloid leukaemia patients with intermediate mutant FLT3/ITD levels do not have detectable bi-allelic disease, indicating that heterozygous disease alone is associated with an adverse outcome.. Br J Haematol, 142(3), 423 - 426. doi:10.1111/j.1365-2141.2008.07196.x
    • Mead AJ, Gale RE, Hills RK, Gupta M, Young BD, Burnett AK, Linch DC (2008). Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease.. Blood, 112(2), 444 - 445. doi:10.1182/blood-2008-02-140392
    • Gale R, Hills R, Green C, Patel Y, Gilkes A, Lazenby M, Wheatley K, Linch DC, Burnett A (2008). The Impact of FLT3-ITD and NPM1 Mutational Status on the Outcome of ATRA Therapy in Patients with Non-APL AML: Results of the UK MRC AML12 Trial.
    • Mansour MR, Sulis ML, Duke V, Foroni L, Jenkinson S, Allen CG, Gale RE, Buck G, Richards S, Paietta E, Tallman M, Goldstone AH, Rowe JM, Ferrando AA, Linch DC (2008). Unlike Paediatric T-ALL, Notch-1 and FBXW7 Mutations Do Not Seem to Predict a Better Outcome in Adult Patients: Data from the UKALLXII/ECOG2993 Protocol..
    • Mead AJ, Thomson KJ, Morris EC, Chakraverty R, Linch DC, Mackinnon S, Peggs KS (2008). Mismatch at 1-2 HLA Loci Does Not Reduce Survival Following Alemtuzumab-Based Reduced Intensity Unrelated Donor Allogeneic Transplantation.
    • Lambert JR, Gale R, Linch DC (2008). The Relationship Between Wild Type and Mutant-Positive Platelets in Essential Thrombocythemia Patients with a JAK2 V617F Mutation.
    • Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC, Cazier JB, Young BD (2008). Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes, Chromosomes and Cancer, 47(9), 729 - 739.

    2007

    • Mansour MR, Duke V, Foroni L, Patel B, Allen CG, Ancliffe P, Gale RE, Linch DC (2007). Notch-1 mutations can be secondary events in some patients with T-cell acute lymphoblastic leukemia.. Clinical Cancer Research, 13(23), 6964 - 6969.
    • Smith BN, Ancliff PJ, Linch DC, Gale RE (2007). Identification of two novel homozygous HAX1 mutations in an autosomal recessive Jewish and two unrelated sporadic British families with severe congenital neutropenia.
    • Mead AJ, Linch DC, Hills RK, Wheatley K, Burnett AK, Gale RE (2007). FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia.. Blood, 110(4), 1262 - 1270.
    • Swerdlow AJ, Higgin CD, Smith P, Cunningham D, Hancock BW, Horwich A, Hoskin PJ, Lister A, Radford JA, Rohatiner AZ, Linch DC (2007). Myocardial infarction mortality risk after treatment for Hodgkin diseae: a collabortive British cohort study.. Journal of the National Cancer Institute, 99(3), 206 - 214. doi:10.1093/jnci/djk029
    • Virappane P, Gale RE, Hills RK, Kakkas K, Summers K, Stevens J, Green CL, Allen CG, Quentmeier H, Drexler H, Burnett AK, Linch DC, Bonnet D, Listens TA, Fitzgibbon J (2007). Wilms' tumour 1 mutation in normal karyotype aml.
    • Swerdlow AJ, Higgins CD, Smith P, Cunningham D, Hancock BW, Horwich A, Hoskin PJ, Lister A, Radford JA, Rohatiner AZS, Linch DC (2007). Myocardial infarction mortality risk after treatment for Hodgkin disease: A collaborative British cohort study.
    • Gisselbrecht C, Schmitz N, Mounier N, Ma D, Tmeny M, Hagberg H, Linch DC, Shpilberg O, Ketterer N, Glass B, Bosly A, Gill D, Gaulard P, Moskowitz C (2007). R-ICE versus R-DHAP in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL) followed by stem cell transplantation and maintenance treatment with rituximab or not: First interim analysis on 200 patients. CORAL study.
    • Rao AG, Ancliff PJ, Webb DK, Linch DC, Gale RE (2007). The occurrence of mutations in PTPN11 and KRAS is not dissimilar in patients with indolent juvenile myelomonocytic leukemia (JMML) from those with clinically more aggressive disease.
    • Bloor A, Thomson K, Chowdury N, Verfeuth S, Ings S, Chakraverty R, Goldstone A, Linch D, Peggs KAM, S (2007). High response rate to donor lymphocyte infusion (DLI) following allogeneic stem cell transplanatation for indolent non-Hodgkin's Lymphoma. Biology of Blood and Marrow Transplantation, , - .
    • Gale RE, Hills R, Wheatley K, Burnett AK, Linch DC (2007). Still a need for more robust evidence that FLT3/ITD status should influence the decision to proceed to transplantation in AML patients. BLOOD, 109(5), 2265 - 2265.
    • Thomson KJ, Peggs KS, Blundell E, Goldstone AH, Linch DC (2007). A second autologous transplant may be efficacious in selected patients with Hodgkin's lymphoma relapsing after a previous autograft.. Leuk Lymphoma, 48(5), 881 - 884. doi:10.1080/10428190701216394
    • Mansour M, Duke V, Patel B, Ancliff P, Foroni L, Gale RE, Linch DC (2007). Analysis of paired presentation and relapse samples in T-ALL suggests that, at least in some patients, Notch-1 mutations may be acquired as a secondary event.
    • Peggs KS, Sureda A, Qian W, Caballero D, Hunter A, Urbano-Ispizua A, Cavet J, Ribera JM, Parker A, Canales M, Mahendra P, Garcia-Conde J, Milligan D, Sanz G, Thomson K, Arranz R, Goldstone AH, Alvarez I, Linch DC, Sierra J, Mackinnon S, UK Spanish Collaborative Grps (2007). Reduced-intensity conditioning for allogeneic haematopoietic stem cell transplantation in relapsed and refractory Hodgkin lymphoma: impact of alemtuzumab and donor lymphocyte infusions on long-term outcomes. BRIT J HAEMATOL, 139(1), 70 - 80. doi:10.1111/j.1365-2141.2007.06759.x
    • Mackinnon S, Thomson KJ, Goldstone AH, Linch DC, Peggs KS (2007). Improved outcome following reduced intensity allogeneic transplantation in Hodgkin's lymphoma relapsing post-autologous transplantation.
    • Virappane P, Gale RE, Hills R, Kakkas I, Summers K, Stevens J, Green C, Allen C, Burnett AK, Linch DC, Bonnet D, Lister TA, Fitzgibbon J (2007). Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemoresistance in normal karyotype acute myeloid leukemia.
    • Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC, Cazier JB, Young B (2007). A genome-wide map of acquired uniparental disomy in acute myeloid leukemia.
    • Gale RE, Allen AJ, Nash MJ, Linch DC (2007). Long-term serial analysis of X-chromosome inactivation patterns and JAK2 V617F mutant levels in patients with essential thrombocythemia show that minor mutant-positive clones can remain stable for many years. Blood, 109(3), 1241 - 1243.

    2006

    • Gale RE, Allen AJR, Nash MJ, Linch DC (2006). Lack of correlation of clonality status with the level of Val617Phe JAK2 mutant in essential thrombocythaemia (ET) indicates that the JAK2 when present, is not the primary pathogenic event.
    • Ings SJ, Balsa C, Leverett D, Mackinnon S, Linch DC, Watts MJ (2006). Peripheral blood stem cell yield in 400 normal donors mobilised with granulocyte colony-stimulating factor (G-CSF): impact of age, sex, donor weight and type of G-CSF used.. British Journal of Haematology, 134(5), 517 - 525.
    • Descamps MJ, Barrett L, Groves M, Yung L, Birch R, Murray NM, Linch DC, Lunn MP, Reilly MM (2006). Primary sciatic nerve lymphoma: a case report and review of the literature.. J Neurol Neurosurg Psychiatry, 77(9), 1087 - 1089. doi:10.1136/jnnp.2006.087577
    • Betticher DC, Martinelli G, Radford JA, Kaufmann M, Dyer MJ, Kaiser U, Aulitzky WE, Beck J, von Rohr A, Kovascovics T, Cogliatti SB, Cina S, Maibach R, Cerny T, Linch DC (2006). Sequential high dose chemotherapy as initial treatment for aggressive sub-types of non-Hodgkin lymphoma: results of the international randomized phase III trial (MISTRAL).. Annals of Oncology, 17(10), 1546 - 1552.
    • Grandage VL, Everington T, Linch DC, Khwaja A (2006). Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.. Br J Haematol, 135(3), 303 - 316. doi:10.1111/j.1365-2141.2006.06291.x
    • Kyriakou C, Rabin N, Nathwani A, Pizzey A, Linch DC, Yong K (2006). Factors influencing short term in vivo biodistribution of human bone marrow derived mesenchymal stem cells (hMSCs) in a xenogeneic animal model..
    • Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ (2006). Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.. Blood, 108(7), 2182 - 2189. doi:10.1182/blood-2006-01-010249
    • Mansour MR, Linch DC, Foroni L, Goldstone AH, Gale RE (2006). High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia.. Leukemia, 20(3), 537 - 539. doi:10.1038/sj.leu.2404101
    • Everington TF, Linch DC, Khwaja A (2006). Reversal of apoptosis resistance and erythropoietin independent growth of primary erythroid progenitors from patients with polycythaemia vera (PV) by inhibitors of the Jak2 tyrosine kinase.
    • Everington TF, Henderson S, Gale R, Linch DC, Khwaja A (2006). Primary erythroblasts from patients with polycythaemia vera (PV) have a distinct gene expression signature from both idiopathic erythrocytosis (IE) and normal controls which shows limited changes in Jak-STAT target genes.
    • Mead AJ, Linch DC, Hills R, Wheatley K, Burnett AK, Gale RE (2006). The favourable prognostic impact of tyrosine kinase domain mutations of FLT3 in AML is related to the level of mutation.
    • Gale RE, Hills R, Wheatley K, Burnett AK, Linch DC (2006). Response: Allogeneic stem cell transplantation and FLT3/ITD status in AML. BLOOD, 108(1), 400 - 401.
    • Burton C, Linch D, Hoskin P, Milligan D, Dyer MJS, Hancock B, Mouncey P, Smith P, Qian W, MacLennan K, Jack A, Webb A, Cunningham D (2006). A phase III trial comparing CHOP to PMitCEBO with or without G-CSF in patients aged 60 plus with aggressive non-Hodgkin's lymphoma. BRITISH JOURNAL OF CANCER, 94(6), 806 - 813.

    2005

    • Gale RE, Hills R, Pizzey AR, Kottaridis PD, Swirsky D, Gilkes AF, Nugent E, Mills KI, Wheatley K, Solomon E, Burnett AK, Linch DC, Grimwade D (2005). The relationship between FLT3 mutation status, biological characteristics and response to targeted therapy in acute promyelocytic leukemia.. Blood, 106(12), 3768 - 3776. doi:10.1182/blood-2005-04-1746
    • Gale RE, Hills R, Pizzey AR, Kottaridis PD, Swirsky D, Gilkes AF, Nugent E, Mills KI, Wheatley K, Solomon E, Burnett AK, Linch DC, Grimwade DNCRIALWP (2005). Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia.. Blood, 106(12), 3768 - 3776. doi:10.1182/blood-2005-04-1746
    • Hoskin PJ, Smith P, Maughan TS, Gilson D, Vernon C, Syndikus I, Linch DC, British National Lymphoma Investigation (2005). Long-term results of a randomised trial of involved field radiotherapy vs extended field radiotherapy in stage I and II Hodgkin lymphoma.. Clin Oncol (R Coll Radiol), 17(1), 47 - 53.
    • Grandage VL, Gale RE, Linch DC, Khwaja A (2005). PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways.. Leukemia, 19(4), 586 - 594. doi:10.1038/sj.leu.2403653
    • Bowen DT, Frew ME, Hills R, Gale RE, Wheatley K, Groves MJ, Langabeer SE, Kottaridis PD, Moorman AV, Burnett AK, Linch DC (2005). RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.. Blood, 106(6), 2113 - 2119.
    • Ardeshna KM, Kakouros N, Qian W, Powell MG, Saini N, D'Sa S, Mackinnon S, Hoskin PJ, Goldstone AH, Linch DC (2005). Conventional second-line salvage chemotherapy regimens are not warranted in patients with malignant lymphomas who have progressive disease after first-line salvage therapy regimens.. Br J Haematol, 130(3), 363 - 372. doi:10.1111/j.1365-2141.2005.05603.x
    • Raghavan M, Gale RE, Skoulakis S, Chaplin T, Molloy GY, Linch DC, Burnett AK, Young BD (2005). An increased frequency of abnormalities including uniparental disomy is detected by SNP array compared with conventional karyotype analysis in acute myeloid leukemia..
    • Thomson KJ, Morris EC, Milligan D, Cook G, Cavet J, Craddock C, Hunter A, Schey S, Parker A, Goldstone AH, Linch DC, Peggs KS, Mackinnon S (2005). Reduced intensity allogeneic transplantation for non-Hodgkin's Lymphoma: Extended follow-up of an alemtuzumab-containing regimen..
    • Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM (2005). Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK (vol 131, pg 193, 2005). BRIT J HAEMATOL, 131(5), 673 - 673.
    • Gale RE, Hills R, Burnett AK, Linch , DC EA (2005). No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.. Blood, 106(10), 3658 - 3665. doi:10.1182/blood-2005-03-1323
    • Gale RE, Hills R, Kottaridis P, Srirangan S, Wheatley K, Burnett A, Linch DC (2005). No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.. Blood, 106(10), 3658 - 3665. doi:10.1182/blood-2005-03-1323
    • Mansour MR, Dogan A, Morris EC, Khwaja A, Linch DC, Mackinnon S, Peggs KS (2005). Allogeneic transplantation for hepatosplenic allphabeta T-cell lymphoma.. Bone Marrow Transplantation, 35(9), 824 - 829.
    • Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM (2005). Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK. BRITISH JOURNAL OF HAEMATOLOGY, 131(2), 193 - 200.
    • Mudie NY, Swerdlow AJ, Higgins CD, Smith P, Qiao ZK, Hancock BW, Hoskin PJ, Linch DC (2005). Risk of second malignancy after non-Hodgkin's lymphoma: A British cohort study. JOURNAL OF CLINICAL ONCOLOGY, 24(10), 1568 - 1574. doi:10.1200/JCO.2005.04.2200
    • Peggs KS, Mackinnon S, Linch DC (2005). The role of allogeneic transplantation in non-Hodgkin's lymphoma.. British Journal of Haematology, 128(2), 153 - 168.
    • Nathwani AC, Davidoff AM, Linch DC (2005). A review of gene therapy for haematological disorders. BRIT J HAEMATOL, 128(1), 3 - 17. doi:10.1111/j.1365-2141.05231.x
    • Hart DP, Avivi I, Thomson KJ, Peggs KS, Morris EC, Goldstone AH, Linch DC, Ell PJ, Bomanji JB, Mackinnon S (2005). Use of 18F-FDG positron emission tomography following allogeneic transplantation to guide adoptive immunotherapy with donor lymphocyte infusions.. Br J Haematol, 128(6), 824 - 829. doi:10.1111/j.1365-2141.2005.05388.x
    • Simon M, Grandage VL, Linch DC, Khwaja A (2005). Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia.. Oncogene, 24(14), 2410 - 2420. doi:10.1038/sj.onc.1208431
    • Grandage VL, Linch DC, Khwaja A (2005). Go6976 is a novel and potent inhibitor of JAK2 and JAK3 tyrosine kinases both in vitro and in cellular assays.
    • Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshina KM (2005). Central nervous system chemoprophylaxis in non-Hodgkin's lymphoma: A questionnaire-based survey evaluating current practice in the United Kingdom.
    • Thomson KJ, Peggs KS, Sureda A, Hunter A, Caballero MD, Cavet J, Urbano-Ispizua A, Parker A, Ribera JM, Mahendra P, Milligan D, Morris EC, Goldstone AH, Linch DC, Sierra J, Mackinnon S (2005). Impact of in vivo T cell depletion on outcome following reduced intensity transplantation with matched related donors for Hodgkin lymphoma: comparison between two prospective studies.
    • Thomson KJ, Peggs KS, Morris EC, Khwaja A, Linch DC, Goldstone AH, Mackinnon S (2005). Allogeneic stem cell transplantation with T cell depletion for acute myeloid leukaemia.
    • Grandage VL, Linch DC, Khwaja A (2005). Go6976, a novel and potent inhibitor of JAK2 and JAK3, reduces constitutive STAT activity and induces apoptosis in myeloid leukaemia and anaplastic lymphoma cells.
    • Mansour MR, Dogan A, Morris EC, Khwaja A, Linch DC, Mackinnon S, Peggs KS (2005). Allogeneic transplantation for hepatosplenic alphabeta T-cell lymphoma.. Bone Marrow Transplant, 35(9), 931 - 934. doi:10.1038/sj.bmt.1704897
    • Peggs KS, Hunter A, Chopra R, Parker A, Mahendra P, Milligan D, Craddock C, Pettengell R, Morris E, Hale G, Waldmann H, Goldstone AH, Linch DC, Mackinnon S (2005). Clinical evidence of a graft versus Hodgkin's Lymphoma effect following reduced intensity allogeneic transplantation.. The Lancet, 365(9475), 1934 - 1941. doi:10.1016/S0140-6736(05)66659-7
    • Betticher D, von Rohr A, Kovacsovics T, Martinelli G, Cerny T, Linch DC, Dyer MJS, Radford JA, Kaiser U, Kaufmann M, Aulitzky WE, Beck J, Maibach R, Cina S (2005). Sequential high-dose chemotherapy (SHDC) with autologous stem cell transplantation (ASCT) vs standard CHOP regimen for pts with untreated aggressive NHL. Result of the mistral trial from the Swiss Group for Clinical Cancer Research (SAKK).
    • Thomson KJ, Peggs KS, Smith P, Chopra R, Cavet J, Hunter A, Parker A, Pettengell R, Milligan D, Morris EC, Goldstone AH, Linch DC, Mackinnon S (2005). Improved outcome following reduced intensity allogeneic transplantation in Hodgkin's lymphoma relapsing post-autologous transplantation..
    • Mansour MR, Linch DC, Foroni L, Goldstone AH, Gale RE (2005). High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukaemia..
    • Thomson KJ, Peggs KS, Morris EC, Khwaja A, Linch DC, Goldstone AH, Mackinnon S (2005). Allogeneic stem cell transplantation for high-risk acute myeloid leukemia: No increase in relapse with alemtuzumab-depleted grafts..
    • Cooper N, Avivi I, Karl PS, Hart DQ, Thomson K, Bloor AJC, Goldstone AH, Linch DC, Ell P, Bomanji J, Mackinnon S (2005). The use of PET scans to direct immunotherapy following reduced intensity stem cell transplants in adults with lymphoid malignancies.
    • Nathwani AC, Davidoff AM, Linch DC (2005). A review of gene therapy for haematological disorders.. Br J Haematol, 128(1), 3 - 17. doi:10.1111/j.1365-2141.2004.05231.x

    2004

    • Guinn BA, Gilkes AF, Mufti GJ, Linch D, Burnett AK, Mills KI (2004). Use of cDNA microarray analysis to identify cancer testes antigen expression in presentation acute myeloid leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 125, 51 - .
    • Balsa C, Watts MJ, Ings SJ, Linch DC (2004). Unexpected differences in the thaw clonogenic recovery of pre-stressed peripheral blood stem cells according to the cryoprotectant used.
    • Grimwade D, Gale R, Hills R, Kottaridis P, Swirsky D, Gilkes A, Nugent E, Mills K, Wheatley K, Solomon E, Burnett AK, Linch DC, NCRI Adult Leukaemia Working Party (2004). The relationship between FLT3 mutation status, biological characteristics and outcome in patients with acute promyelocytic leukaemia.
    • Gandini D, Allen AJ, Nash MJ, Linch DC, Gale RE (2004). No mutations in the GATA-1 gene detected in patients with acquired essential thrombocythemia.. Haematologica, 89(5), 613 - 615.
    • Yung L, Smith P, Hancock BW, Hoskin P, Gilson D, Vernon C, Linch DC (2004). Long term outcome in adolescents with Hodgkin's lymphoma: poor results using regimens designed for adults. LEUKEMIA & LYMPHOMA, 45(8), 1579 - 1585.
    • Morris E, Thomson K, Craddock C, Mahendra P, Milligan D, Cook G, Smith GM, Parker A, Schey S, Chopra R, Hatton C, Tighe J, Hunter A, Peggs K, Linch D, Goldstone A, Mackinnon S (2004). Outcomes after alemtuzumab-containing reduced-intensity allogeneic transplantation regimen for relapsed and refractory non-Hodgkin lymphoma. Blood, 104(13), 3865 - 3871. doi:10.1182/blood-2004-03-1105
    • Avivi I, Chakrabarti S, Kottaridis P, Kyriaku C, Dogan A, Milligan D, Linch D, Goldstone AH, Mackinnon S (2004). Neurological complications following alemtuzumab-based reduced- intensity allogeneic transplantation. BONE MARROW TRANSPLANTATION, 34(2), 137 - 142.
    • Spicer J, Smith P, Maclennan K, Hoskin P, Hancock B, Linch D, Pettengell R (2004). Long-term follow-up of patients treated with radiotherapy alone for early-stage histologically aggressive non-Hodgkin's lymphoma. British Journal of Cancer, 90(6), 1151 - 1155.
    • Burton C, Ell PJ, Linch D (2004). The role of PET imaging in lymphoma.. British Journal of Haematology, 126, 772 - 784.
    • Avivi I, Chakrabarti S, Milligan D, Waldmann H, Hale G, Osman H, Ward K, Fegan C, Yong K, Goldstone A, Linch D, Mackinnon S (2004). Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 10(3), 186 - 194.
    • Peggs KS, Thomson K, Hart DL, Geary J, Morris E, Yong K, Goldstone A, Linch D, Mackinnon S (2004). Dose-escalated donor lymphocyte infusions following reduced intensity transplantation: toxicity, chimerism, and disease responses. Blood, 103(4), 1548 - 1556. doi:10.1182/blood-2003-05-1513
    • Kyriakou CA, Goldstone AH, Sureda A, Yong K, D'Sa S, Taghipour G, de Elvira CR, Linch DC, Schmitz N (2004). Patients with lymphoplasmacytic lymphoma can be salvaged with autologous stem cell transplantation, irrespectively of the number of previous treatment lines. Analysis of 146 cases from the European Bone Marrow Transplant Registry (EBMT)..
    • Jakupovic I, Grandage VL, Linch DC, Khwaja A (2004). Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells. Blood, 103(8), 3230 - 3232. doi:10.1182/blood-2003-06-1985
    • Watts MJ, Ings SJ, Balsa C, Penn C, Linch DC (2004). Thermally induced catastrophic cryocyte breaks.
    • Ahmed F, Ings SJ, Pizzey AR, Blundell MP, Thrasher AJ, Ye HT, Fahey A, Linch DC, Yong KL (2004). Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model. Blood, 103(6), 2079 - 2087. doi:10.1182/blood-2003-06-1770
    • Peggs KS, Thomson K, Hunter A, Chopra R, Mahendra P, Milligan D, Parker A, Pettengell R, Craddock C, Hale G, Waldmann H, Morris EC, Goldstone AH, Linch DC, Mackinnon S (2004). Exploiting alloreactivity in relapsed and refractory Hodgkin Lymphoma: long-term follow-up of a T-cell-depleted reduced intensity transplant protocol.
    • Hart DP, Thomson KJ, Bannerjee L, Morris EC, Linch DC, Goldstone AH, Peggs KS, Mackinnon S (2004). Very low dose aciclovir prophylaxis postallogeneic stem cell transplantation prevents varicella zoster infection without development of clinically relevant resistance.
    • Allen AJR, Nash MJ, Linch DC, Gale RE (2004). Increased expression of the low affinity IgG receptor FcR gamma IIA (CD32) in platelet RNA from patients with chronic myeloproliferative disorders demonstrated by representational difference analysis.
    • Peggs KS, Verfuerth S, Chow C, Thomson K, Goldstone AH, Linch DC, Mackinnon S (2004). Adoptive cellular therapy for cytomegalovirus following allogeneic stem cell transplantation: Toxicity and efficacy.
    • Peggs KS, Sureda A, Hunter A, Caballero MD, Cavet J, Urbano-Ispizua A, Parker A, Ribera JM, Mahendra P, Canales MA, Milligan D, Hernandez-Boluda JC, Morris HBC, Alvarez I, Goldstone AH, Linch DC, Sierra J, Mackinnon S (2004). Impact of in vivo T-cell depletion on outcome following reduced intensity transplantation for Hodgkin lymphoma: Comparison between 2 prospective studies.
    • Kyriakou CA, Goldstone AH, Sureda A, Yong K, Taghipour G, de Elvira CR, Linch DC, Mackinnon S, Schmitz N (2004). Role of allogeneic stem cell transplantation in lymphoplasmacytic lymphoma. Analysis of 61 cases from the European Bone Marrow Registry (EBMT)..
    • Watts MJ, Ings SJ, Balsa C, Penn C, Leverett D, Linch DC (2004). Successful customization of peripheral blood stem cell harvest volume and cell concentration during apheresis..

    2003

    • Kyriacou C, KOTTARIDIS PD, Eliahoo J, McKEAG N, Bomford J, McGarrigle HH, Linch DC, MACKINNON S, Chatterjee R (2003). Germ cell damage and Leydig celi insufficiency in recipients of nonmyeloablative transplantation for malignancies. Bone Marrow Transplantation, 31(1), 45 - 50.
    • Ahmed F, Ings SJ, Pizzey AR, Blundell MP, Thrasher AJ, Ye HT, Fahey A, Linch DC, Yong KL (2003). Impaired bone marrow homing of cytokine activated CD34+ cells in the NOD/SCID model. BLOOD, , - .
    • Ancliff P, Gale RE, Liesner R, Hann I, Linch D (2003). Long Term Follow up of Granulocyte Colony-stimulating factor receptor mautations in patients with severe congenital neutropenia: implications for leukaemogenesis and therapy. British Journal of Haematology, 120(4), 685 - 690. doi:10.1046/j.1365-2141.2003.04160.x
    • Somervaille TC, Linch DC, Khwaja A (2003). Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors.. Br J Haematol, 120(5), 876 - 886.
    • Ancliff PJ, Gale RE, Linch DC (2003). Neutrophil elastase mutations in congenital neutropenia.. Hematology, 8(3), 165 - 171. doi:10.1080/1024533031000107497
    • Kottaridis PD, Gale RE, Linch DC (2003). Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia.. Leuk Lymphoma, 44(6), 905 - 913. doi:10.1080/1042819031000067503
    • Bowen DT, Frew MEC, Hills R, Gale RE, Wheatley K, Groves MJ, Langabeer SE, Kottaridis PD, Burnett AK, Linch DC (2003). RAS gene mutation in acute myeloid leukemia; Analysis of cases from the medical research council AML 10 and 12 clinical trials..
    • Ardeshna KM, Kakouros N, Qian WD, Powell MG, Saini N, D'Sa S, Hoskin PJ, Goldstone AH, Linch DC (2003). Conventional second-line salvage chemotherapy regimens are not warranted in patients with malignant lymphomas who have progressive disease in response to first line salvage chemotherapy regimens..
    • Grandage VL, Linch DC, Khwaja A (2003). P13Kinase is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NFkB, MAPKinase and P53 pathways..
    • Simon M, Grandage VL, Linch DC, Khwaja A (2003). Constitutive activation of the Wnt/beta-catenin pathway impairs myelomonocytic differentiation of normal progenitors and is found in acute myeloid leukaemia..
    • Luong QT, Hills RK, Drayson MT, Wheatley K, Burnett AK, Linch DC, Bunce CM (2003). Expression of Nm23-H1 in AML correlates with white cell count at diagnosis and in vitro acts as a survival factor for primary AMLs cells; Evidence of a novel autocrine survival factor in AML..
    • Gandini D, Allen AJR, Nash MJ, Linch DC, Gale RE (2003). No mutations in the GATA-1 gene detected in patients with the acquired myeloproliferative disorder essential thrombocythaemia..
    • Peggs KS, Mackinnon S, Williams CD, D'Sa S, Thuraisundaram D, Kyriacou C, Morris EC, Hale G, Waldmann H, Linch DC, Goldstone AH, Yong K (2003). Reduced intensity transplantation with in vivo T-cell depletion and adjuvant dose-escalating donor lymphocyte infusions for chemotherapy-senstive myeloma: limited efficacy of graft-versus-tumor activity.. Biology of Blood and Marrow Transplantation, 9(4), 257 - 265. doi:10.1053/bbmt.2003.50009
    • Ardeshna KM, Smith P, Norton A, Hancock BW, Hoskin PJ, MacLennan KA, Marcus RE, Jelliffe A, Vaughan G, Hudson LDC (2003). Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trial.. The Lancet, 362(9383), 516 - 522. doi:10.1016/S0140-6736(03)14110-4
    • Kyriacou C, Kottaridis PD, Eliahoo J, McKeag N, Bomford J, McGarrigle HH, Linch DC, Mackinnon S, Chatterjee R (2003). Germ cell damage and Leydig cell insufficiency in recipients of nonmyeloablative transplantation for haematological malignancies.. Bone Marrow Transplantation, 31(1), 45 - 50.
    • Kottaridis PD, Gale RE, Linch DC (2003). Flt3 mutations and leukaemia.. Br J Haematol, 122(4), 523 - 538.
    • Chelvatheebam S, Langabeer SE, Linch DC, Hills RK, Greenwell P (2003). Incidence and prognostic significance of C-MPL expression in acute myeloid leukemia.. Leukemia Research, 27(9), 869 - 870.
    • Watts MJ, Ings SJ, Balsa C, Ahmed F, Scott M, Richardson K, Linch DC (2003). Storage of PBSC in liquid phase for 16 hours leads to occult progenitor cell damage only fully apparent after freeze thawing..
    • Peggs KS, Thomson K, Chopra R, Mahendra P, Milligan D, Parker A, Hunter A, Pettengell R, Craddock CF, Hale G, Waldmann H, Morris EC, Goldstone AH, Linch DC, Mackinnon S (2003). Long term results of reduced intensity transplantation in multiply relapsed and refractory Hodgkin's lymphoma: Evidence of a therapeutically relevant graft-versus-lymphoma effect..
    • Hart DP, Avivi I, Thomson KJ, Goldstone AH, Linch DC, Ell PJ, Bomanji JB, Morris EC, Peggs KS, Mackinnon S (2003). Use of Positron Emission Tomography following reduced intensity allograft for Hodgkin and Non Hodgkin Lymphoma to guide Donor Lymphocyte Infusion administration..
    • Hart DP, Thomson KJ, Bannerjee L, Morris EC, Linch DC, Goldstone AH, Peggs KS, Mackinnon S (2003). Very low dose aciclovir prophylaxis post allogeneic stem cell transplantation prevents varicella zoster infection without development of clinically relevant resistance..
    • Luong QT, Hills RK, Drayson MT, Wheatley K, Burnett AK, Linch DC, Bunce CM (2003). Expression of Nm23-H1 in AML correlates with white cell count at diagnosis and in vitro acts as a survival factor for primary AMLs cells; Evidence of a novel autocrine survival factor in AML. BLOOD, 102(11), 2255 - .

    2002

    • Watts MJ, Somervaille TCP, Ings SJ, Ahmed F, Khwaja A, Yong K, Linch DC (2002). Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS((R)) (v2 center dot 1) and Isolex((R)) 300i (v2 center dot 5) clinical scale devices. BRIT J HAEMATOL, 118(1), 117 - 123.
    • Chakrabarti S, Avivi I, MACKINNON S, Ward K, KOTTARIDIS PD, Osman H, Waldmann H, Hale G, Fegan CD, Yong K, GOLDSTONE AH, Linch DC, Milligan DW (2002). Respiratory virus infections in transplant recipients after reduced-intensity conditioning with Campath-1H: high incidence but low mortality. British Journal of Haematology, 119(4), 1125 - 1132.
    • Chatterjee R, KOTTARIDIS PD, McGarrigle HH, Linch DC (2002). Management of erectile dysfunction by combination therapy with testosterone and sildenafil in recipients of high-dose therapy for haematological malignancies. Bone Marrow Transplantation, (607), 610 - .
    • Linch DC, Yung L, Smith P, MacLennan K, Jack A, Hancock B, Cunningham D, Hoskin P, Holte H, Boesen AM, Grigg A, Browett P (2002). A randomised trial of CHOP x 6-8 vs CHOP x 3+BEAM + ASCT in 457 patients with poor prognosis histologically aggressive non- Hodgkins lymphoma. British Journal of Cancer, 86, S1 - S2.
    • Grimwade D, Outram SV, Flora R, Ings SJ, Pizzey AR, Morilla R, Craddock CF, Linch DC, Solomon E (2002). The T-lineage-affiliated CD2 gene lies within an open chromatin environment in acute promyelocytic leukemia cells.. , , - .
    • Peggs KS, Morris EC, Kottaridis PD, Geary J, Goldstone AH, Linch DC, Mackinnon S (2002). Conditioning regimen may influence outcome of ABO incompatible non-myeloablative haemtopoietic allogeneic stem cell transplantation.. Blood, 99, 4642 - 4644.
    • Langabeer SE, Gale RE, Harvey RC, Cook RW, Mackinnon S, Linch DC (2002). Transcription-mediated amplification and hybridisation protection assay to determine BCR-ABL transcript levels in patients with chronic myeloid leukaemia.. Leukemia, 16(3), 393 - 399. doi:10.1038/sj.leu.2402392
    • Chatterjee R, Kottaridis PD, McGarrigle HH, Linch DC (2002). Management of erectile dysfunction by combination therapy with testosterone and sildenafil in recipients of high-dose therapy for haematological malignancies.. Bone Marrow Transplantation, 29(7), 607 - 610.
    • Chatterjee R, Kottaridis PD, McGarrigle HH, Linch DC (2002). Post-transplant complications - Management of erectile dysfunction by combination therapy with testosterone and sildenafil in recipients of high-dose therapy for haematological malignancies. BONE MARROW TRANSPL, 29(7), 607 - 610. doi:10.1038/sj/bmt/1703421
    • Langabeer SE, Gale RE, Rollinson SJ, Morgan GJ, Linch DC (2002). Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.. Genes Chromosomes Cancer, 34(1), 24 - 32.
    • Watts MJ, Somervaille TC, Ings SJ, Ahmed F, Khwaja A, Yong K, Linch DC (2002). Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices.. Br J Haematol, 118(1), 117 - 123.
    • Ancliff PJ, Gale RE, Watts MJ, Liesner R, Hann IM, Strobel S, Linch DC (2002). Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia.. Blood, 100(2), 707 - 709. doi:10.1182/blood-2002-01-0060
    • Imrie KR, Linch DC, Czuczman MS (2002). Debate on the conservative and aggressive treatment options for the optimal management of indolent non-Hodgkin's lymphoma.. Anti-Cancer Drugs, 13(2), S19 - S24.
    • Perez-Simon JA, Kottaridis PD, Martino R, Craddock C, Caballero D, Chopra R, Garcia-Conde J, Milligan DW, Schey S, Urbano-Ispizua A, Parker A, Leon A, Yong K, Sureda A, Hunter A, Sierra J, Goldstone AH, Linch DC, San Miguel JF, Mackinnon S Spanish and United Kingdom Collaborative Groups for Nonmyeloablative TRANSPLANTATION (2002). Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders.. Blood, 100(9), 3121 - 3127.
    • Kyriacou CA, Goldstone AH, Taghipour G, Avivi I, Kottaridis PD, Dogan A, Linch DC, Schmitz N (2002). Patients with chemosensitive angioimmunoblastic lymphoma (AITL) can be salvaged with autologous stem cell transplantation, irrespectively of the number of previous treatment lines. Analysis of 74 cases from the European Bone Marrow Transplant Registry (EBMT)..
    • Mills KI, Gilkes AF, Linch DC, Burnett AK (2002). Risk group stratification in AML by the use of micro-arrays..
    • Yong KL, Fahey A, Pahal G, Linch DC, Pizzey A, Thomas NSB, Jauniaux E, Kinnon C, Thrasher AJ (2002). Fetal haemapoietic cells display enhanced migration across endothelium. British Journal of Haematology, 116, 392 - 400. doi:10.1046/j.1365-2141.2002.03273.x
    • Yong KL, Fahey A, Pizzey A, Linch DC (2002). Influence of cell cycling and cell division on transendothelial migration of CD34+ cells.. British Journal of Haematology, , - .
    • Forbes LV, Gale RE, Pizzey A, Pouwels K, Nathwani A, Linch DC (2002). An activating mutation in the transmembrane domain of the granulocyte colony-stimulating factor receptor in patients with acute myeloid leukemia.. Oncogene, 21(39), 5981 - 5989. doi:10.1038/sj.onc.1205767
    • Chakraverty R, Peggs K, Chopra R, Milligan D, Kottaridis P, Verfuerth S, Geary J, Thuraisundaram D, Branson K, Mahendra P, Craddock C, Parker A, Hunter A, Hale G, Waldmann H, Williams C, Yong K, Linch DC, Goldstone A, Mackinnon S (2002). Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen.. Blood, 99(3), 1071 - 1078.
    • Kottaridis PD, Gale RE, Langabeer SE, Frew ME, Bowen DT, Linch DC (2002). Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood, 100(7), 2393 - 2398. doi:10.1182/blood-2002-02-0420
    • Branson K, Chopra R KPD, Parker A SS, Chakraverty R, Craddock C, Milligan DW, Marsh J, Linch D, Goldstone A W, C and Mckinnon S (2002). The role of nonmyeloablative stem cell transplantation after failure of autologous transplant in patients with lymphoproliferative malignancies.. Journal of Clinical Oncology, 20, 4022 - 4031.
    • Kottaridis PD, Peggs K, Schmitz N, Dreger P, Boogaerts MA, Ferrant A, Demuynck HM, Zander A, Link H, Matcham J, Linch DC, Borkett K, Goldstone AH (2002). Survival and freedom from progression in autotransplant lymphoma patients is independent of stem cell source: further follow-up from the original randomised study to assess engraftment.. Leukemia and Lymphoma, 43(3), 531 - 536.
    • Langabeer SE, Gale RE, Harvey RC, Cook RW, Mackinnon S, Linch DC (2002). Transcription-mediated amplification and hybridisation protection assay to determine BCR-ABL transript levels in patients with chronic myeloid leukaemia. LEUKEMIA, 16(3), 393 - 399. doi:10.1038/sj/leu/2402392
    • Watts MJ, Somervaille TCP, Ings SJ, Ahmed F, Khwaja A, Linch DC (2002). Isolex 300i and CliniMACS clinical scale CD34 selection devices: A split harvest comparison. LEUKEMIA, 16(3), 416 - 416.
    • Peggs KS, Morris EC, Kottaridis PD, Geary J, Goldstone AH, Linch DC, Mackinnon S (2002). Outcome of major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation may be influenced by conditioning regimen.. Blood, 99(12), 4642 - 4643.
    • Chakrabarti S, Mackinnon S, Chopra R, Kottaridis PD, Peggs K, O'Gorman P, Chakraverty R, Marshall T, Osman H, Mahendra P, Craddock C, Waldmann H, Hale G, Fegan CD, Yong K, Goldstone AH, Linch DC, Milligan DW (2002). High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.. Blood, 99(12), 4357 - 4363.
    • Avivi I, Bacon CM, Obermann EC, Quian WD, Smith P, Linch DC, Dogan A (2002). Histological and clinical prognostic factors in follicular lymphoma: Proposal for a prognostic model..
    • Kottaridis PD, Gale RE, Holt M, Wheatley K, Goldstone AH, Burnett AK, Linch DC (2002). Consolidation of AML therapy with autograft and allograft procedures does not negate the poor prognostic impact of FLT3 internal tandem duplications: Results from the UK MRC AML 10 and 12 trials..
    • Peggs KS, Thomson K, Geary J, Morris E, Kottaridis P, Watts M, Yong K, Linch DC, Goldstone AH, Mackinnon S (2002). Dose escalating donor lymphocyte infusions (DLI) following T-depleted reduced intensity allografting: High response rates associated with conversion to full donor chimerism (FDC) are not durable despite persistent donor chimerism..
    • Ancliff PJ, Gale RE, Somerville TC, Kwaja A, Liesner R, Hann IM, Linch DC (2002). Complete inhibition of neutrophil elastase fails to correct the in vitro phenotype of severe congenital neutropenia..
    • Kottaridis PD, Craddock C, Chopra R, Milligan DW, Vandenberghe E, Parker A, Hunter A, Schey S, Smith G, Hatton C, Hale G, Waldmann H, Peggs K, Avivi I, Linch DC, Goldstone AH, Mackinnon S (2002). Reduced intensity allogeneic transpalntation in patients above the age of 50 years..
    • Hoskin PJ, Smith P, Linch DC (2002). Late morbidity and survival in early stage Hodgkin's disease treated with involved field or wide field radiotherapy alone.

    2001

    • Langabeer SE, Rogers JR, Harrison G, Wheatley K, Walker H, Bain BJ, Burnett AK, Goldstone AH, Linch DC, Grimwade D MRC Adult Leukaemia Working PARTY (2001). EVI1 expression in acute myeloid leukaemia.. British Journal of Haematology, 112(1), 208 - 211.
    • Ahmed F, Ings SJ, Pizzey A, Fahey A, Blundell M, Hardy SJ, Thrasher A, Linch DC, Yong KL (2001). Cytokine exposure impairs short-term homing of CD34(+) cells in SCID/NOD mice: Influence of cell cycle status.. BLOOD, 98(11), 644A - 644A.
    • Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, Walker H, Wheatley K, Bowen DT, Burnett AK, Goldstone AH, Linch DC (2001). The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the UK MRC AML 10 and 12 trials. Blood, 98(6), 1752 - 1759.
    • Mollapour E, Linch DC, Roberts PJ (2001). Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosol. Blood, 97(8), 2469 - 2477.
    • Mollapour E, Linch DC, Roberts PJ (2001). Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A(2).. Blood, 97(8), 2469 - 2477.
    • Hancock BW, Gregory WM, Cullen MH, Hudson GV, Burton A, Selby P, Maclennan KA, Jack A, Bessell EM, Smith P, Linch DC, British National Lymphoma Investigation , Central Lymphoma Group (2001). ChlVPP alternating with PABlOE is superior to PABlOE alone in the initial treatment of advanced Hodgkin's disease: results of a British National Lymphoma Investigation/Central Lymphoma Group randomized controlled trial.. Br J Cancer, 84(10), 1293 - 1300. doi:10.1054/bjoc.2001.1778
    • Ardeshna KM, Smith P, Linch DC, BNLI (2001). The long-term impact of a watch and wait policy vs immediate systemic treatment for asymptomatic advanced stage indolent non Hodgkins lymphoma: Results of a British national lymphoma randomised trial. BRIT J CANCER, 85, 2 - 2.
    • Somervaille TC, Linch DC, Khwaja A (2001). Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.. Blood, 98(5), 1374 - 1381.
    • Allen AJ, Gale RE, Harrison CN, Machin SJ, Linch DC (2001). Lack of pathogenic mutations in the 5'-untranslated region of the thrombopoietin gene in patients with non-familial essential thrombocythaemia.. Eur J Haematol, 67(4), 232 - 237.
    • Ancliff PJ, Gale RE, Liesner R, Hann IM, Linch DC (2001). Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease. Blood, 98(9), 2645 - 2650. doi:10.1182/blood.V98.9.2645
    • Wedderburn LR, Jeffery R, White H, Patel A, Varsani H, Linch D, Murray K, Woo P (2001). Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype. Rheumatology (Oxford), 40(11), 1299 - 1307.
    • Ancliff PJ, Gale RE, Hann IM, Strobel S, Linch DC (2001). Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia.. BLOOD, 98(11), 439A - 439A.
    • Truran LN, Austin SJ, Langabeer SE, Kottaridis PD, Linch DC, Fisher J, Burnett AK (2001). Quantitative bax and FLT3-ITD characterisation improve prognostic stratification in AML patients with intermediate risk cytogenetics.. BLOOD, 98(11), 578A - 578A.
    • Kottaridis PD, Gale RE, Langabeer SE, Linch DC (2001). Changes in the pattern of FLT3 mutations between diagnosis and relapse restricts their potential use as markers of minimal residual disease in patients with acute myeloid leukaemia.. BLOOD, 98(11), 717A - 718A.
    • Kottaridis PD, Milligan DW, Chopra R, Chakraverty RK, Chakrabarti S, Robinson S, Peggs K, Verfuerth S, Pettengell R, Marsh JC, Schey S, Mahendra P, Morgan GJ, Hale G, Waldmann H, Ruiz de Elvira MC, Williams CD, Devereux S, Linch DC, Goldstone AH, MacKinnon S (2001). In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation.. Cytotherapy, 3(3), 197 - 201. doi:10.1080/146532401753174025
    • Watts MJ, Ings SJ, Ahmed F, Smith R, Mackinnon S, Linch DC (2001). Clinical scale depletion of CD3+CD8+expressing T-cells from mobilised donor PBSC products using the eligix High Density Magnetic Particle (HDM) device. BONE MARROW TRANSPL, 27, S125 - S125.
    • Swerdlow A, Schoemaker M, Allerton R, Horwich A, Barber J, Cunningham D, Lister T, Rohatiner A, Vaughan Hudson G, Williams M, Linch D (2001). Lung cancer after Hodgkin's disease: a nested case-control study of the relation to treatment. Journal of Clinical Oncology, 19(6), 1610 - 1618.
    • Jaswon MS, Linch DC (2001). Priming of neutrophil function in the newborn.. British Journal of Haematology, 113(4), 1078 - 1079.
    • Chakraverty R, Robinson S, Peggs K, Kottaridis PD, Watts MJ, Ings SJ, Hale G, Waldmann H, Linch DC, Goldstone AH, Mackinnon S (2001). Excessive T cell depletion of peripheral blood stem cells has an adverse effect upon outcome following allogeneic stem cell transplantation.. Bone Marrow Transplant, 28(9), 827 - 834. doi:10.1038/sj.bmt.1703248
    • Somervaille TCP, Linch DC, Khwaja A (2001). p38 MAP kinase regulates both differentiation and apoptosis in primary human erythroid cells.. BLOOD, 98(11), 78A - 79A.
    • Kyriakou CA, Milligan D, Chopra R, Craddock C, Chakraverty R, Mahendra P, Pettengell R, Hunter A, Parker A, Vanderberghe E, Hatton C, Schey S, Kottaridis PD, Peggs K, Morris E, Hale G, Waldmann H, Linch DC, Goldstone AH, Mackinnon S (2001). Outcome of non-myeloablative stem cell transplantation for NHL is dependent on histology: Good for patients with low grade disease and poor for those with high grade lymphoma..
    • Kottaridis PD, Milligan DW, Chopra R, Craddock C, Kyriacou C, Peggs K, Cakrabati S, Geary J, Thuraisundaram D, Mahendra P, Chakraverty R, Hunter A, Pettengell R, Hale G, Waldmann H, Linch DC, Goldstone AH, Mackinnon S (2001). Non-myeloablative transplantation for patients with Hodgkin's disease: Limited transplant related mortality and possible evidence of a graft versus Hodgkin's effect..
    • Ancliff PJ, Blundell MP, Gale RE, Liesner R, Hann IM, Thrasher AJ, Linch DC (2001). Activating mutations in theWiskott Aldrich syndrome protein may define a sub-group of severe congenital neutropenia (SCN) with specific and unusual laboratory features.. BLOOD, 98(11), 439A - 440A.
    • Harris E, Mahendra P, McGarrigle HH, Linch DC, Chatterjee R (2001). Gynaecomastia with hypergonadotrophic hypogonadism and Leydig cell insufficiency in recipients of high-dose chemotherapy or chemo-radiotherapy. Bone Marrow Transplantation, 28, 1141 - 1144.

    2000

    • Ardeshna KM, Corney CP, Ings SJ, Watts MJ, Linch DC, Devereux S (2000). A clinically applicable method for the ex vivo generation of antigen-presenting cells from CD34+ progenitors.. Vox Sanguinis, 79(1), 46 - 52.
    • Peggs KS, Preiser W, Kottaridis PD, McKeag N, Brink NS, Tedder RS, Goldstone AH, Linch DC, Mackinnon S (2000). Extended routine polymerase chain reaction surveillance and pre-emptive antiviral therapy for cytomegalovirus after allogeneic transplantation.. Br J Haematol, 111(3), 782 - 790.
    • Ardeshna KM, Pizzey AR, Thomas NS, Orr S, Linch DC, Devereux S (2000). Monocyte-derived dendritic cells do not proliferate and are not susceptible to retroviral transduction.. , , - .
    • Linch DC, Smith P, Hancock BW, Hoskin PJ, Cunningham DC, Newland AC, Milligan D, Stevenson PA, Wood JK, Maclennan KA, Vaughan B, Vaughan G, Gregory WM (2000). A randomized British National Lymphoma Investigation trial of CHOP vs. a weekly multi-agent regimen (PACEBOM) in patients with histologically aggressive non-Hodgkin's lymphoma.. Annals of Oncology, 11(1), 87 - 90.
    • Swerdlow AJ, Barber JA, Hudson GV, Cunningham D, Gupta RK, Hancock BW, Horwich A, Lister TA, Linch DC (2000). Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment.. J Clin Oncol, 18(3), 498 - 509.
    • Langabeer SE, Gale RE, Walker H, Linch DC (2000). Reported cryptic rearrangements of CBFbeta-MYH11 in acute myeloid leukaemia are not due to false priming of contaminating DNA.. Leukemia, 14(5), 944 - 945.
    • Robertson JD, Gale RE, Wynn RF, Dougal M, Linch DC, Testa NG, Chopra R (2000). Dynamics of telomere shortening in neutrophils and T lymphocytes during ageing and the relationship to skewed X chromosome inactivation patterns.. Br J Haematol, 109(2), 272 - 279.
    • Greene JN, Linch DC, Miller CB (2000). Current treatments for infection in neutropenic patients with hematologic malignancy.. Oncology (Williston Park), 14(8), 31 - 34.
    • Watts MJ, Ings SJ, Flynn M, Dodds D, Goldstone AH, Linch DC (2000). Remobilization of patients who fail to achieve minimal progenitor thresholds at the first attempt is clinically worthwhile.. British Journal of Haematology, 111(1), 287 - 291.
    • Ardeshna KM, Walker SJ, Devereux S, Linch DC, Khwaja A (2000). The p38 stress activated protein kinase mediates the increased responsiveness of mature dendritic cells to macrophage inhibitory protein 3 beta (MIP3 beta) and secondary lymphoid chemokine (SLC).. BLOOD, 96(11), 33A - 33A.
    • Somervaille TCP, Linch DC, Khwaja A (2000). Survival signalling in primary human erythroblasts occurs through PI3-kinase/Akt/GSK3 and not the classical MAP kinase pathway.. BLOOD, 96(11), 79A - 79A.
    • Ahmed F, Watts MJ, Ings SJ, Flynn M, Linch DC (2000). Poor viability of freshly apheresed PBSC harvests: Implications for overnight storage before cryopreservation or additional manipulative procedures.. BLOOD, 96(11), 380A - 380A.
    • Side LE, Peniket AJ, Levy ER, Williamson H, Humphray SJ, Langabeer SE, Walker H, Goldstone AH, Linch DC, Burnett AK, Boultwood J, Wainscoat JS (2000). Molecular characterization of the chromosome 9q deletion in AML.. BLOOD, 96(11), 542A - 542A.
    • Allen AJR, Gale RE, Harrison CN, Machin SJ, Linch DC (2000). Lack of pathogenic mutations in the 5 ' UTR of the thrombopoietin gene in patients with non-familial essential thrombocythaemia.. BLOOD, 96(11), 742A - 742A.
    • Sud R, Gale RE, Harrison CN, Machin SJ, Linch DC (2000). Mutations in the TGF beta RII gene are unlikely to be responsible for the reduced sensitivity to TGF beta in megakaryocytes from patients with essential thrombocythaemia.. BLOOD, 96(11), 743A - 743A.
    • Cunningham D, Mainwaring PN, Gregory W, Hoskin P, Hancock B, Smith P, Hudson GV, Linch D (2000). Mitoxantrone is superior to doxorubicin in a multi-agent weekly regimen for patients with high-grade lymphoma over the age of 60 years: Results of a BNLI randomised trial of PACEBO vs. British Journal of Cancer, 83 (Su, 1 - .
    • Watts MJ, Ings SJ, Leverett D, MacMillan A, Devereux S, GOLDSTONE AH, Linch DC (2000). ESHAP and G-CSF is a superior blood stem cell mobilizing regimen compared to cyclophosphamide 1.5 g m(-2) and G-CSF for pre-treated lymphoma patients: a matched pairs analysis of 78 patients. British Journal of Cancer, 82(2), 278 - 282.
    • Linch DC, Gosden RG, Tulandi T, Tan SL, Hancock SL (2000). Hodgkin's Lymphoma: Choice of Therapy and Late Complications.. Hematology Am Soc Hematol Educ Program, , 205 - 221.
    • Macdonald C, Walker S, Watts M, Ings S, Linch DC, Devereux S (2000). Effect of changes in expression of the amphotropic retroviral receptor PiT-2 on transduction efficiency and viral titer: implications for gene therapy.. Human Gene Therapy, 11(4), 587 - 595.
    • Kottaridis PD, Milligan DW, Chopra R, Chakraverty RK, Chakrabarti S, Robinson S, Peggs K, Verfuerth S, Pettengell R, Marsh JC, Schey S, Mahendra P, Morgan GJ, Hale G, Waldmann H, de Elvira MC, Williams CD, Devereux S, Linch DC, Goldstone AH, Mackinnon S (2000). In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation.. Blood, 96(7), 2419 - 2425.
    • Robinson SP, Addada J, Green N, Wong WL, Shaw P, Chakraverty R, Goldstone AH, Macmillan A, Linch DC (2000). Response to short course ESHAP chemotherapy in relapsed and refractory lymphoma.. BLOOD, 96(11), 246B - 246B.
    • Mills AK, Goldstone AH, Linch DC, Peggs KS, Kyriakou C, Mackinnon S (2000). Long-term follow-up of allogeneic bone marrow transplants for lymphoma: The case for conventional conditioning regimens..
    • Ancliff PJ, Gale RE, Liesner R, Hann IM, Linch DC (2000). Mutations in ELA2 encoding for neutrophil elastase are a frequent finding in sporadic but not familial severe congenital neutropenia.. BLOOD, 96(11), 445A - 445A.
    • Kottaridis PD, Milligan DW, Mahendra P, Chopra R, Chakraverty R, Chakrabarti S, Peggs K, Robinson S, Verfuerth S, Parker A, Hunter DE, Pettengell R, Marsh JCW, Shey S, Morgan GJ, Williams CD, Hale G, Waldmann H, Yong K, Devereux S, Linch DC, Goldstone AH, Mackinnon S, UK Collaborative Study (2000). Non-myeloablative conditioning limits transplant related mortality in patients who have previously failed high dose treatment..
    • Langabeer SE, Gale RE, Rollinson SJ, Morgan GJ, Linch DC (2000). Mutations in the AML1 gene in acute myeloid leukaemia patients with FAB types M0 and M7.. BLOOD, 96(11), 698A - 698A.
    • Watts MJ, Somervaille TCP, Ings SJ, Ahmed F, Khwaja A, Yong K, Linch DC (2000). Variable product purity and functional capacity after CD34+cell selection: A comparison of the CliniMACS and Isolex 300i clinical scale devices.. BLOOD, 96(11), 773A - 773A.
    • Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, Walker H, Wheatley K, Bowen DT, Burnett AK, Goldstone AH, Linch DC (2000). The presence of a FLT3 mutation in AML adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the MRC AML 10 and 12 trials.. BLOOD, 96(11), 825A - 825A.
    • Peggs KS, Mahendra P, Milligan DW, Chopra R, Chakraverty RK, Kottaridis PD, Chakrabarti S, Mills AK, Parker A, Hunter AE, Hale G, Waldmann H, Pettengell R, Marsh JCW, Schey S, Williams CD, Yong K, Linch DC, Goldstone AH, Mackinnon S, UK Collaborative Grp (2000). Non-myeloablative transplantation using matched unrelated donors - In vivo CAMPATH-1H limits graft versus host disease..
    • Linch DC, Smith P, Hancock BW, Hoskin PJ, Cunningham DC, Newland AC, Milligan D, Stevenson PA, Wood JK, Maclennan KA, Hudson BV, Hudson GV, Gregory WM (2000). A randomised British National Lymphoma Investigation trial of CHOP vs. a weekly multi-agent regimen (PACEBOM) in patients with histologically aggressive non-Hodgkin's lymphoma. Annals of Oncology, 11, 87 - 90.

    1999

    • Harrison CN, Gale RE, Pezzella F, Mire-Sluis A, Machin SJ, Linch DC (1999). Platelet c-mpl expression and plasma thrombopoietin levels are dysregulated in patients with thrombocytosis; regardless of clonal status. British Journal of Haematology, 107, 139 - 147.
    • Gale RE, Forbes LV, Pizzey A, Pouwels K, Linch DC (1999). A leukemia-associated mutation in the G-CSF receptor implies a role for the transmembrane domain in receptor activation.. BLOOD, 94(10), 45A - 45A.
    • Yong K, Fahey A, Reeve L, Nicholls C, Thomas NS, Pizzey A, Ings SJ, Watts MJ, Linch DC (1999). Cord blood progenitor cells have greater transendothelial migratory activity and increased responses to SDF-1 and MIP-3beta compared with mobilized adult progenitor cells.. , , - .
    • Devereux S, Corney C, Macdonald C, Watts M, Ward M, Bank A, Linch DC (1999). Multi-drug resistance (MDR-1) gene transfer in patients with poor prognosis lymphoma undergoing high dose therapy and CD34 selected peripheral blood stem cell transplantation (PBSCT). BONE MARROW TRANSPL, 23, S85 - S85.
    • Perry AR, Peniket AJ, Watts MJ, Leverett D, Goldstone AH, Linch DC (1999). Peripheral blood stem cell versus autologous bone marrow transplantation for Hodgkin's disease: equivalent survival outcome in a single-centre matched-pair analysis.. British Journal of Haematology, 105(1), 280 - 287.
    • Ardeshna KM, Pizzey AR, Thomas NSB, Linch DC, Devereux S (1999). Proliferative capacity and susceptibility to retroviral transduction of CD34 and monocyte derived dendritic cells.. BRIT J HAEMATOL, 105, 29 - 29.
    • Ardeshna KM, Addison IE, Pizzey AR, Linch DC, Devereux S, Khwaja A (1999). P38 stress-activated protein kinase activity is required for the lipopolysaccharide-induced maturation of monocyte-derived dendritic cells.. BRIT J HAEMATOL, 105, 33 - 33.
    • Langabeer SE, Grimwade D, Walker H, Burnett AK, Goldstone AH, Linch DC (1999). EV1-1 expression in acute promyelocytic leukaemia.. BRIT J HAEMATOL, 105, 74 - 74.
    • Haynes AP, Kottiridis P, Byrne JL, Goldstone A, Russell NH, Linch DC, McKinnon S (1999). Results of allogeneic transplantation for lymphoma - A report on 41 patients.. BRIT J HAEMATOL, 105, 87 - 87.
    • Robertson JD, Gale R, Wynn RF, Robinson SA, Greaves MJ, Dougal M, Linch DC, Boyle J, Testa NG, Chopra R (1999). Telomere shortening in peripheral blood neutrophils and T cells with age in healthy individuals. BRIT J HAEMATOL, 105, 103 - 103.
    • Wheadon H, Roberts PJ, Watts MJ, Linch DC (1999). Changes in signal transduction downstream from the granulocyte-macrophage colony-stimulating factor receptor during differentiation of primary hemopoietic cells.. Experimental Hematology, 27(6), 1077 - 1086.
    • Cullen M, Hancock BW, Gregory WM, Hudson GV, Burton A, Selby P, Maclennan KA, Jack A, Bessell EM, Linch DC (1999). Ch1VPP/PABIOE is superior to PABIOE: Interim results of the British national lymphoma investigation/central lymphoma group randomised trial in advanced Hodgkin's disease.. BRIT J CANCER, 80, 18 - 18.
    • Roberts PJ, Mollapour E, Watts MJ, Linch DC (1999). Primitive myeloid cells express high levels of phospholipase A(2) activity in the absence of leukotriene release: selective regulation by stem cell factor involving the MAP kinase pathway.. Blood, 94(4), 1261 - 1272.
    • Sweetenham JW, Carella AM, Taghipour G, Cunningham D, Marcus R, Della Volpe A, Linch DC, Schmitz N, Goldstone AH (1999). High-dose therapy and autologous stem-cell transplantation for adult patients with Hodgkin's disease who do not enter remission after induction chemotherapy: results in 175 patients reported to the European Group for Blood and Marrow Transplantation. Lymp. Journal of Clinical Oncology, 17(10), 3101 - 3109.
    • Harrison CN, Gale RE, Pezella F, Mire-Sluis A, MacHin SJ, Linch DC (1999). Platelet c-mpl expression is dysregulated in patients with essential thrombocythaemia but this is not of diagnostic value.. Br J Haematol, 107(1), 139 - 147.
    • Yong K, Fahey A, Thomas NSB, Inge S, Watts M, Linch DC (1999). Transendothelial migration of CD34(+) cells requires growth factor activation and occurs predominantly in G(0)/G(1) phase of the cell cycle.. BLOOD, 94(10), 40A - 40A.
    • Ings SJ, Schey S, Hancock B, Watts MJ, Vandenberghe E, Goldstone AH, Elston T, Pettengell R, Long S, Smith P, Linch DC (1999). Results of a BNLI randomized trial of G-CSF dose after cyclophosphamide 1.5g/m(2) for progenitor cell mobilization.. BLOOD, 94(10), 666A - 666A.
    • Linch DC, Goldstone AH (1999). High-dose therapy for Hodgkin's disease.. British Journal of Haematology, 107(4), 685 - 690.
    • Harrison CN, Gale RE, Machin SJ, Linch DC (1999). A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications.. Blood, 93(2), 417 - 424.
    • Mackinnon S, Kottaridis P, Perry A, Chakrabarti S, Milligan DW, Pettengell R, Chopra R, Morgan G, Hale G, Waldmann H, Linch DC, Devereux S, Goldstone AH (1999). Preliminary results of an non-myeloablative conditioning regimen for allogeneic stem cell transplantation.. BRIT J HAEMATOL, 105, 31 - 31.
    • Watts MJ, Ings SJ, Chavda N, Mackinnon S, Devereux S, Linch DC (1999). Evaluation of clinical scale CD34+cell purification devices. BRIT J HAEMATOL, 105, 58 - 58.
    • Khwaja A, Hassan R, Tatton EL, Watts M, Linch DC (1999). Inhibition of myeloid cell apoptosis by G-CSF and GM-CSF involves different signal transduction pathways depending on the stage of differentiation.. BRIT J HAEMATOL, 105, 102 - 102.
    • Pollard Y, Watts MJ, Grant D, Chavda N, Linch DC, Machin SJ (1999). Use of the haemopoietic progenitor cell count of the Sysmex SE-9500 to refine apheresis timing of peripheral blood stem cells.. British Journal of Haematology, 106(2), 538 - 544.
    • Harrison CN, Gale RE, Mire-Sluis A, Machin SJ, Linch DC (1999). Essential thrombocythaemia with polyclonal haemopoiesis is not due to disruption in levels of interleukins-6,-11, thrombopoietin, or transforming growth factor beta 1 levels.. BLOOD, 94(10), 112A - 112A.
    • Kottaridis PD, Peggs K, Harrison C, Angus G, Peniket A, Miller B, Devereux S, Mackinnon S, Linch DC, Goldstone AH (1999). Age over 60 is not a barrier for successful autologous stem cell transplantation in selected patients with lymphoma: A single institution's experience in 37 consecutive patients..
    • Ardeshna KM, Linch DC, Devereux S, Khwaja A (1999). p38 stress-activated protein kinase and NF-kappa B activity are required for lipopolysaccharide-induced maturation of monocyte-derived dendritic cells.. BLOOD, 94(10), 214A - 214A.
    • Robertson J, Gale RE, Linch DC, Testa NG, Chopra R (1999). Acquired skewed haemopoiesis in the elderly is independent of telomere shortening-implications for stem cell utilisation.. BLOOD, 94(10), 254A - 254A.
    • Langabeer SE, Gale RE, Mackinnon S, Linch DC (1999). Transcription mediated amplification and hybridisation protection assay to determine BCR-ABL transcript levels in patients with chronic myeloid leukaemia.. BLOOD, 94(10), 283A - 283A.
    • Watts MJ, Ings SJ, Flynn M, Dodds D, MacMillan A, Goldstone AH, Linch DC (1999). Remobilization of poor stem cell mobilizers is clinically worthwhile.. BLOOD, 94(10), 328A - 328A.
    • Peggs KS, Kottaridis PD, Preiser W, McCaig N, Brink N, Ward K, Tedder R, Goldstone AH, Linch DC, Mackinnon S (1999). Molecular monitoring for CMV infection after allogeneic transplantation: Benefits and limitations of PCR directed pre-emptive antiviral therapy..
    • Kottaridis PD, Chakraverty R, Milligan DW, Chakrabarti S, Robinson S, Chopra R, Pettengell R, Marsh J, Mahendra P, Schey S, Morgan GH, Williams C, Hale G, Waldmann H, Linch DC, Devereux S, Goldstone AH, Mackinnon S (1999). A non myeloablative regimen for allografting high-risk patients: Low toxicity, stable engraftment without GVHD, disease control and potential for GVL with adoptive immunotherapy.. BLOOD, 94(10), 348A - 348A.
    • Harrison CN, Gregory W, Hudson GV, Devereux S, Goldstone AH, Hancock B, Winfield D, MacMillan AK, Hoskin P, Newland AC, Milligan D, Linch DC (1999). High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML. British Journal of Cancer, 81, 476 - 483.

    1998

    • Langabeer SE, Linch DC (1998). IL-1 receptor antagonist gene polymorphism in patients with secondary acute myeloid leukaemia. Cytokines, Cellular and Molecular Therapy, 4(1), 7 - 9.
    • Bernard T, Gale RE, Evans JP, Linch DC (1998). Mutations of the granulocyte-colony stimulating factor receptor in patients with severe congenital neutropenia are not required for transformation to acute myeloid leukaemia and may be a bystander phenomenon. British Journal of Haematology, 101(1), 141 - 149.
    • Linch DC (1998). Non-Hodgkin's Lymphoma: Histologically Aggressive. In Whittaker JA, Holmes JA (Ed.), Leukaemia and related disorders (pp. 376 - 391). : Blackwell Science Ltd.
    • Harrison CN, Vaughan G, Devereux S, Linch DC (1998). Outcome of secondary myeloid malignancy in Hodgkin's disease: the BNLI experience. European Journal of Haematology, 61(2), 109 - 112.
    • Perry AR, Watts MJ, Peniket AJ, Goldstone AH, Linch DC (1998). Progenitor cell yields are frequently poor in patients with histologically indolent lymphomas especially when mobilized within 6 months of previous chemotherapy. Bone Marrow Transplantation, 21(12), 1201 - 1205.
    • Harrison CN, Gale RE, Linch DC (1998). Quantification of X-chromosome inactivation patterns using RT-PCR of the polymorphic iduronate-2-sulphatase gene and correlation of the results obtained with DNA-based techniques. Leukemia, 12(11), 1834 - 1839.
    • Watts MJ, Sullivan AM, Ings SJ, Barlow M, Devereux S, Goldstone AH, Linch DC (1998). Storage of PBSC at -80 degrees C. Bone Marrow Transplantation, 21(1), 111 - 112.
    • Harrison CN, Gale RE, Wiestner AC, Skoda RC, Linch DC (1998). The activating splice mutation in intron 3 of the thrombopoietin gene is not found in patients with non-familial essential thrombocythaemia. British Journal of Haematology, 102(5), 1341 - 1343.
    • Yong KL, Watts M, Shaun T, Sullivan A, Ings S, Linch DC (1998). Transmigration of CD34+ cells across specialized and nonspecialized endothelium requires prior activation by growth factors and is mediated by PECAM-1 (CD31). Blood, 91(4), 1196 - 1205.
    • Watts MJ, Addison I, Ings SJ, Long SG, Hartley S, Warrington S, Boyce M, Linch DC (1998). Optimal timing for collection of PBPC after glycosylated G-CSF administration.. Bone Marrow Transplantation, 21(4), 365 - 368.
    • Robinson LG, Austin SJ, Owen-Jones CE, Langabeer SE, Linch DC, Mills KI, Burnett AK (1998). Multiplex PCR for the detection of prognostically important gene rearrangements in acute myeloid leukaemia.. BRIT J HAEMATOL, 101, 21 - 21.
    • Langabeer SE, Allford S, Grimwade D, Chatters SJ, Walker H, Oliver FJ, Rogers JR, Arnold J, Bain BJ, Kilby AM, Goldstone AH, Burnett AK, Patterson KG, Linch DC (1998). Two cases of t(15;17) not associated with APL and the value of molecular screening for PML/RAR alpha in AML. BRIT J HAEMATOL, 101, 31 - 31.
    • Ings SJ, Watts MJ, Linch DC (1998). The post G-CSF white cell count is predictive for subsequent apheresis progenitor yields. BRIT J HAEMATOL, 101, 95 - 95.
    • Ardeshna KM, Corney CP, Ings SJ, Watts MJ, Linch DC, Devereux S (1998). Generation of functionally competent antigen presenting cells from CD34+ progenitors suitable for clinical use.. BRIT J HAEMATOL, 101, 101 - 101.
    • Langabeer SE, Grimwade D, Walker H, Rogers JR, Burnett AK, Goldstone AH, Linch DC, MRC Adult Leukaemia Working Party (1998). A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RAR alpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia. BRIT J HAEMATOL, 101(2), 338 - 340.
    • Pollard Y, Watts MJ, Grant D, Chavda N, Linch DC (1998). An adequate CD34+ cell apheresis yield is unlikely with low Sysmex SE-9500 haemopoietic progenitor cell (HPC) blood counts. BRIT J HAEMATOL, 102(1), 76 - 77.
    • Pouwels K, Gale RE, Langabeer S, Linch DC (1998). A G-CSF receptor with a 3bp deletion in the cytoplasmic region due to alternative splicing. BRIT J HAEMATOL, 102(1), 164 - 164.
    • Peniket AJ, Perry AR, Williams CD, MacMillan A, Watts MJ, Isaacson PG, Goldstone AH, Linch DC (1998). A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34- purified autologous peripheral blood progenitor cell transplantation. Bone Marrow Transplantation, 22(3), 307 - 309.
    • Roberts PJ, Mollapour E, Watts MJ, Linch DC (1998). Stem cell factor primes phospholipase A(2) activity in primitive myeloid cells.. BLOOD, 92(10), 364A - 364A.
    • Yong K, Nicholls CA, Fahey A, Thomas NSB, Inge S, Watts M, Linch DC (1998). Enhanced transendothelial migration of cord blood versus adult blood CD34(+) cells correlates with more rapid entry into cell cycle.. BLOOD, 92(10), 587A - 587A.
    • Linch DC, Smith P, Gregory WM, Hoskin P, Cunningham D, Hancock BW, Rhodes E (1998). Preliminary results of a randomised BNLI trial of chop vs CIOP (Idarubicin 10 mg/g(2) replacing hydroxydaunorubicin 50 mg/m(2)) in good prognosis younger patients with histologically aggressive non-Hodgkin's lymphoma (NHL).. BLOOD, 92(10), 620A - 620A.
    • Gale RE, Best AJ, Pouwels K, Park S, Linch DC (1998). Multiple alternatively spliced transcripts of SHP-1 are expressed in primary myeloid cells and change with differentiation.. BLOOD, 92(10), 157B - 157B.
    • Ardeshna KM, Pizzey AR, Linch DC, Devereux S (1998). Monocyte derived dendritic cells do not proliferate and are refractory to transduction by retroviral vectors.. BLOOD, 92(10), 56B - 57B.
    • Khwaja A, Hassan R, Tatton EL, Watts TM, Linch DC (1998). GM-CSF and G-CSF inhibition of apoptosis is mediated by different signal transduction pathways dependent on the stage of myeloid differentiation.. BLOOD, 92(10), 159B - 159B.
    • Harvey RC, Cook RW, Clark TJ, Linch DC (1998). Application of TMA and HPA to the identification of fusion transcripts in archived RNA from patients with leukemia. BLOOD, 92(10), 201B - 201B.
    • Pollard Y, Watts MJ, Grant D, Chavda N, Linch DC, Machin SJ (1998). Use of the haemopoietic progenitor cell (HPC) count of the Sysmex SE-9500 to improve timing for peripheral blood stem cell (PBSC) collection.. BLOOD, 92(10), 305B - 305B.
    • Mollapour E, Porter JB, Kaczmarski R, Linch DC, Roberts PJ (1998). Raised neutrophil phospholipase A2 activity and defective priming of NADPH oxidase and phospholipase A2 in sickle cell disease. Blood, 91(9), 3423 - 3429.
    • Linch DC, Milligan DW, Winfield DA, Kelsey SM, Johnson SA, Littlewood TJ, Smith GM, Hutchinson RM, Goldstone AH, Fielding AK, Hudson GV (1998). G-CSF after PBSC transplantation. British Journal of Haematology, 101, 595 - 596.
    • Ardeshna KM, Corney CP, Ings SJ, Watts MJ, Linch DC, Devereux S (1998). A clinically applicable method for the ex-vivo generation of antigen presenting cells from CD34+ progenitors.. BONE MARROW TRANSPL, 21, S15 - S15.
    • Harrison CN, Mire-Sluis A, Abernethy H, Gale RE, Machin SJ, Linch DC (1998). Markedly reduced expression of the thrombopoietin receptor MPL in platelets from patients with monoclonal and polyclonal essential thrombocythaemia.. BRIT J HAEMATOL, 101, 28 - 28.
    • Mollapour E, Khwaja A, Linch DC, Roberts PJ (1998). Activation and priming of neutrophil NADPH oxidase and phospholipase A(2) are dissociated by inhibition of ERK2 and p38 kinases.. BLOOD, 92(10), 533A - 533A.
    • Langabeer SE, Grimwade D, Walker H, Rogers JR, Burnett AK, Goldstone AH, Linch DC (1998). A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RARalpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia. MRC Adult Leukaemia Working Party. Medical Research Council. British Journal of Haematology, 101(2), 338 - 340.
    • Gale RE, Freeburn RW, Khwaja A, Chopra R, Linch DC (1998). A truncated isoform of the human beta chain common to the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 with increased mRNA expression in some patients with acute leukemia. Blood, 91(1), 54 - 63.
    • Freeburn RW, Gale RE, Linch DC (1998). Activating point mutations in the betaC chain of the GM-CSF, IL-3 and IL-5 receptors are not a major contributory factor in the pathogenesis of acute myeloid leukaemia. British Journal of Haematology, 103(1), 66 - 71.
    • Roberts PJ, Mollapour E, Watts MJ, Linch DC (1998). Activation of phospholipase A2 during differentiation of human haemopoietic progenitor cells. Biochemical Society Transactions, 26(3), S233 - .
    • Watts MJ, Sullivan AM, Leverett D, Peniket AJ, Perry AR, Williams CD, Devereux S, Goldstone AH, Linch DC (1998). Back-up bone marrow is frequently ineffective in patients with poor peripheral-blood stem-cell mobilization. Journal of Clinical Oncology, 16(4), 1554 - 1560.
    • Gale RE, Linch DC (1998). Clonality studies in acute myeloid leukemia. Leukemia, 12(2), 117 - 120.
    • Harrison CN, Linch DC, Machin SJ (1998). Desirability and problems of early diagnosis of essential thrombocythaemia. The Lancet, 351(9106), 846 - 847.
    • Wheadon H, Roberts PJ, Linch DC (1998). Differentiation-linked changes in granulocyte-macrophage colony-stimulating factor receptor mediated signalling in the HL-60 promyelocytic cell line. British Journal of Haematology, 101(1), 82 - 89.
    • Devereux S, Corney C, Macdonald C, Watts M, Sullivan A, Goldstone AH, Ward M, Bank A, Linch DC (1998). Feasibility of multidrug resistance (MDR-1) gene transfer in patients undergoing high-dose therapy and peripheral blood stem cell transplantation for lymphoma. Gene Therapy, 5(3), 403 - 408.
    • Devereux S, Linch DC (1998). Granulocyte-macrophage colony-stimulating factor. In Mire-Sluis A (Ed.), Cytokines (pp. - ). : Academic Press.
    • Peniket AJ, Linch DC (1998). Hodgkin's disease. In Barrett J, Treleaven J (Ed.), Volume 1 The Clinical Practice of Stem-Cell Transplantation (pp. 129 - 149). : Isis Medical Media Ltd.

    1997

    • Williams CD, Linch DC, Watts MJ, Thomas NSB (1997). Cell cycle status and E2F complexes in mobilised CD34+ human haemopoietic progenitor cells before and after cytokine stimulation. EUR J CELL BIOL, 72, 119 - 119.
    • Barnett D, Bird G, Hodges E, Linch DC, Matutes E, Newland AC, Reilly JT, Bain BJ, Amos R, Chapman C, England JM, Hyde K (1997). Guidelines for the enumeration of CD4(+) T lymphocytes in immunosuppressed individuals. CLIN LAB HAEMATOL, 19(4), 231 - 241.
    • Wheadon H, Devereux S, Khwaja A, Linch DC (1997). Granulocyte-macrophage colony stimulating factor receptor alpha and beta chain complexes can form both high and intermediate affinity functional receptors. British Journal of Haematology, 98, 809 - 818.
    • Franklin IM, Pippard MJ, Griffiths RK, Linch DC, Lowe GDO (1997). Consensus conference on unrelated donor bone marrow transplantation: Its use in leukaemias and allied disorders. LEUKEMIA, 11(3), 451 - 452.
    • GordonSmith EC, CamilleriFerrante C, Donaldson C, Fallowfield L, Gratwohl A, Meadow R, Miles B, Moir DJ, Sackett D, Watts G, Warwick RM, Franklin IM, Pippard MJ, Griffiths RK, Linch DC, Lowe GDO (1997). A consensus statement on unrelated donor bone marrow transplantation from the consensus panel chaired by EC Gordon-Smith. BONE MARROW TRANSPL, 19(10), 959 - 962.
    • Basu T, Gale RE, Langabeer S, Linch DC (1997). Glutathione S-transferase theta 1 (GSTT1) gene defect in myelodysplasia and acute myeloid leukaemia.. The Lancet, 349(9063), 1450 - .
    • Langabeer SE, Walker H, Rogers JR, Burnett AK, Wheatley K, Swirsky D, Goldstone AH, Linch DC (1997). Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials. MRC Adult Leukaemia Working Party.. British Journal of Haematology, 99(4), 925 - 928.
    • Gale RE, Fielding AK, Harrison CN, Linch DC (1997). Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age.. Br J Haematol, 98(3), 512 - 519.
    • Vandenberghe E, De Wolf-Peeters C, Vaughan Hudson G, Vaughan Hudson B, Pittaluga S, Anderson L, Linch DC (1997). The clinical outcome of 65 cases of mantle cell lymphoma initially treated with non-intensive therapy by the British National Lymphoma Investigation Group.. British Journal of Haematology, 99(4), 842 - 847.
    • Langabeer SE, Walker H, Gale RE, Wheatley K, Burnett AK, Goldstone AH, Linch DC (1997). Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials. The MRC Adult Leukaemia Working Party. British Journal of Haematology, 96(4), 736 - 739.
    • Smith TJ, Hillner BE, Schmitz N, Linch DC, Dreger P, Goldstone AH, Boogaerts MA, Ferrant A, Link H, Zander A, Yanovich S, Kitchin R, Erder MH (1997). Economic analysis of a randomized clinical trial to compare filgrastim-mobilized peripheral-blood progenitor-cell transplantation and autologous bone marrow transplantation in patients with Hodgkin's and non-Hodgkin's lymphoma. Journal of Clinical Oncology, 15(1), 5 - 10.
    • Williams CD, Linch DC (1997). Interferon alfa-2a. British Journal of Hospital Medicine, 57(9), 436 - 439.
    • Watts MJ, Addison IE, Long SG, Hartley S, Warrington S, Boyce M, Linch DC (1997). Crossover study of the haematological effects and pharmacokinetics of glycosylated and non-glycosylated G-CSF in healthy volunteers. British Journal of Haematology, 98(2), 474 - 479.
    • Williams CD, Linch DC, Watts MJ, Thomas NS (1997). Characterization of cell cycle status and E2F complexes in mobilized CD34+ cells before and after cytokine stimulation. Blood, 90(1), 194 - 203.
    • Basu T, Gale RE, Langabeer SE, Linch DC (1997). Glutathione S-transferase theta 1 (GSTT1) gene defect in myelodysplasia and acute myeloid leukaemia [letter]. The Lancet, 349(9063), 1450 - 1450.
    • Freeburn RW, Gale RE, Wagner HM, Linch DC (1997). Analysis of the coding sequence for the GM-CSF receptor alpha and beta chains in patients with juvenile chronic myeloid leukemia (JCML). Experimental Hematology, 25(4), 306 - 311.
    • Williams CD, Linch DC, Sorensen TS, La Thangue NB, Thomas NS (1997). The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130. British Journal of Haematology, 96(4), 688 - 696.
    • Linch DC, Vaughan H, Anderson LV (1997). Impact of high-dose salvage therapy (BEAM) on overall survival in younger patients with advanced large-cell lymphomas entered into BNLI trials. Annals of Oncology, 8 Supp, 63 - 65.
    • Williams SL, Addison IE, Mollapour E, Czaplewski L, Linch DC, Roberts PJ (1997). The effects of human macrophage inflammatory protein 1à and its genetically modified variant BB10010 on phagocytes. Cytokines and Molecular Therapy, 3, 41 - 50.
    • Vandenberghe EA, De Wolf P, Vaughan H, Pittaluge S, Anderson L, Linch DC (1997). The clinical outcome of 65 cases of mantle cell lymphoma treated by the British National Lymphoma Investigation group with initial non-intensive therapy. British Journal of Haematology, 99, 842 - 847.
    • Watts MJ, Linch DC (1997). Peripheral blood stem cell transplantation.. Vox Sanguinis, 73(3), 135 - 142.
    • Langabeer SE, Walker H, Gale RE, Wheatley K, Burnett AK, Goldstone AH, Linch DC (1997). Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the UK MRC AML trials. BRIT J HAEMATOL, 96(4), 736 - 739.
    • Watts MJ, Sullivan AM, Ings SJ, Leverett D, Peniket AJ, Perry AR, Williams CD, Devereux S, Goldstone AH, Linch DC (1997). Evaluation of clinical scale CD34+ cell purification: experience of 71 immunoaffinity column procedures.. Bone Marrow Transplantation, 20(2), 157 - 162.
    • Freeburn RW, Gale RE, Linch DC (1997). RT-PCR-SSCP analysis of the extracellular region of the beta common chain for the GM-CSF, IL-3 and IL-5 receptors in patients with AML.. BLOOD, 90(10), 3524 - 3524.
    • Austin SJ, Robinson LG, OwenJones CE, Langabeer SE, Linch DC, Mills KI, Burnett AK (1997). Multiplex PCR detection of 11q23 abnormalities in acute myeloid leukaemia.. BLOOD, 90(10), 3666 - 3666.
    • Robinson LG, OwenJones E, Bowen D, Langabeer SE, Linch DC, Mills KI, Burnett AK (1997). Multiplex PCR for the detection of prognostically important chromosomal abnormalities in acute myeloid leukaemia.. BLOOD, 90(10), 276 - 276.
    • Kottaridis PD, Peniket AJ, Perry AR, Harrison CN, deElvira MCR, MacMillan A, Devereux S, Linch DC, Goldstone AH (1997). The length of the first complete remission (1-6 months; 7-12 months; >12 months) does not predict outcome following BEAM and autotransplantation for Hodgkin's disease in first relapse. BLOOD, 90(10), 496 - 496.
    • Peniket AJ, Kottaridis PD, Perry AR, deElvira MCR, Devereux S, Macmillan A, Goldstone AH, Linch DC (1997). Outcome of BEAM autotransplantation in patients with Hodgkin's disease progressing on first line therapy is the same as in patients transplanted in first partial remission.. BLOOD, 90(10), 497 - 497.
    • Macdonald C, Corney C, Watts M, Inges S, Linch DC, Devereux S (1997). Receptor binding is a limiting factor in the transduction of CD34(+) hematopoietic cells with amphotropic retroviral vectors.. BLOOD, 90(10), 507 - 507.
    • Watts MJ, Sullivan AM, Leverett D, Peniket AJ, Williams CD, Devereux S, Goldstone AH, Linch DC (1997). Backup bone marrow is frequently ineffective in patients with poor peripheral blood progenitor cell mobilization.. BLOOD, 90(10), 938 - 938.
    • Harrison CN, Gale RE, Machin SJ, Linch DC (1997). Polyclonal haemopoiesis is frequent in patients diagnosed with essential thrombocythaemia.. BLOOD, 90(10), 1549 - 1549.
    • Peniket AJ, Perry AR, Leverett D, Watts M, Sullivan A, Linch DC, Goldstone AH (1997). Which PBPC patients may benefit from accelerated platelet recovery? Factors affecting hospital discharge in 152 consecutive patients, the relevance of CD34 dose and the potential implications of megakaryocyte growth factor.. BLOOD, 90(10), 1701 - 1701.
    • Linch DC, Milligan DW, Winfield DA, Kelsey SM, Johnson SA, Littlewood TJ, Smith GM, Hutchinson RM, Goldstone AH, Fielding AK, Vaughan Hudson G (1997). G-CSF after peripheral blood stem cell transplantation in lymphoma patients significantly accelerated neutrophil recovery and shortened time in hospital: results of a randomized BNLI trial.. British Journal of Haematology, 99(4-II), 933 - 938.
    • Langabeer SE, Walker H, Rogers JR, Burnett AK, Wheatley K, Swirsky D, Goldstone AH, Linch DC (1997). Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials. BRIT J HAEMATOL, 99(4), 925 - 928.
    • Watts MJ, Sullivan AM, Jamieson E, Pearce RM, Fielding AK, Devereux S, Goldstone AH, Linch DC (1997). Progenitor-cell mobilization after low-dose cyclophosphamide and granulocyte colony-stimulating factor: an analysis of progenitor-cell quantity and quality and factors predicting for these parameters in 101 pretreated patients with malignant lymphoma. Journal of Clinical Oncology, 15(2), 535 - 546.

    1996

    • Linch DC, Watts MJ (1996). Standards for PBSC mobilisation and collection.. Annals of Oncology, 7(2), 9 - 10.
    • Boogaerts MA, Brugger W, Carella AM, Cortes-Funes H, Fibbe WE, Hows J, Khayat D, Linch DC, Link H, Moore MA, Testa NG (1996). Peripheral blood progenitor cell transplantation: where do we stand? Chairman's Summary of the European School of Oncology Task Force meeting Peripheral Blood progenitor cell's held September 29-30, 1995.. Annals of Oncology, 7(2), 1 - 4.
    • Linch DC (1996). Intensive chemotherapy and bone marrow transplantation: the challenge of fungal infections. Introduction.. European Journal of Haematology Supplementum, 57, 5 - 6.
    • Roberts PJ, Williams SL, Linch DC (1996). The regulation of neutrophil phospholipase A2 by granulocyte-macrophage colony-stimulating factor and its role in priming superoxide production.. British Journal of Haematology, 92(4), 804 - 814.
    • Williams CD, Watts MJ, Linch DC, Thomas NSB (1996). E2F and p130 are involved in early cell cycle progression of haemopoietic CD34+ stem cells.. BRIT J HAEMATOL, 93, 13 - 13.
    • Watts MJ, Sullivan AM, Goldstone AH, Linch DC (1996). Feasibility of clinical scale CD34+ cell purification of peripheral blood stem cell harvests: Experience of 40 immunoaffinity column procedures.. BRIT J HAEMATOL, 93, 46 - 46.
    • Boultwood J, Fidler C, Mills KI, Frodsham PM, Kusec R, Gaiger A, Gale RE, Linch DC, Littlewood TJ, Moss PA, Wainscoat JS (1996). Amplification of mitochondrial DNA in acute myeloid leukaemia.. Br J Haematol, 95(2), 426 - 431.
    • Freeburn RW, Gale RE, Wagner HM, Linch DC (1996). The beta subunit common to the GM-CSF, IL-3 and IL-5 receptors is highly polymorphic but pathogenic point mutations in patients with acute myeloid leukaemia (AML) are rare.. Leukemia, 10(1), 123 - 129.
    • Gale RE, Mein CA, Linch DC (1996). Quantification of X-chromosome inactivation patterns in haematological samples using the DNA PCR-based HUMARA assay.. Leukemia, 10(2), 362 - 367.
    • Schmitz N, Linch DC, Dreger P, Goldstone AH, Boogaerts MA, Ferrant A, Demuynck HM, Link H, Zander A, Barge A (1996). Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients.. The Lancet, 347(8998), 353 - 357.
    • Gale RE, Bunch C, Moir DJ, Patterson KG, Goldstone AH, Linch DC (1996). Demonstration of developing myelodysplasia/acute myeloid leukaemia in haematologically normal patients after high-dose chemotherapy and autologous bone marrow transplantation using X-chromosome inactivation patterns.. Br J Haematol, 93(1), 53 - 58.
    • Jamal R, Thomas NS, Gale RE, Linch DC (1996). Variable expression of p16 protein in patients with acute myeloid leukemia without gross rearrangements at the DNA level.. Leukemia, 10(4), 629 - 636.
    • Wheadon H, Devereux S, Khwaja A, Linch DC (1996). Activation of the stat 5 and MAP kinase signalling pathways by high and intermediate affinity GM-CSF receptors.. BRIT J HAEMATOL, 93, 11 - 11.
    • Devereux S, Wheadon H, Khwaja A, Linch DC (1996). An insertion in the extracellular domain of the human GM-CSF receptor alpha subunit reduces surface expression by a post-translational mechanism.. BRIT J HAEMATOL, 93, 12 - 12.
    • Wheadon H, Roberts P, Linch DC (1996). GM-CSF receptor mediated activation of stat 5 is increased by neutrophilic differentiation in HL60 cells.. BRIT J HAEMATOL, 93, 85 - 85.
    • Williams SL, Roberts PJ, Addison IE, Mollapour E, Czaplewski L, Linch DC (1996). Studies of the effect of rhMIP-1 alpha on phagocyte function.. BRIT J HAEMATOL, 93, 87 - 87.
    • Sullivan AM, Watts MJ, Leverett D, Williams CD, Goldstone AH, Linch DC (1996). Failure to mobilise peripheral blood stem cells reflects poor quality bone marrow. BRIT J HAEMATOL, 93, 147 - 147.
    • Watts MJ, Sullivan AM, Leverett D, MacMillan AK, Patterson K, Devereux S, Goldstone AH, Linch DC (1996). Evaluation of the ESHAP regimen followed by G-CSF for PBSC mobilisation: A matched pairs analysis compared to low dose cyclophosphamide 1.5g/m(2) plus G-CSF.. BRIT J HAEMATOL, 93, 167 - 167.
    • Langabeer SE, Walker H, Wheatley K, Burnett AK, Goldstone AH, Linch DC (1996). Frequency of CBFB/MYH11 fusion transcripts in acute myelomonocytic leukaemia (AML M4). BRIT J HAEMATOL, 93, 235 - 235.
    • Jamal R, Gale RE, Thomas NSB, Wheatley K, Linch DC (1996). Reduced or abnormal expression of pRb in AML blasts is not a major prognostic factor.. BRIT J HAEMATOL, 93, 256 - 256.
    • Vandenberghe E, DeWolfPeeters C, Hudson GV, Hudson BV, Anderson L, Linch DC (1996). Outcome of mantle cell lymphomas - A study from the British National Lymphoma Investigation Group (BNLI).. BRIT J HAEMATOL, 93, 282 - 282.
    • Williams CD, Watts MJ, Sullivan AM, Leverett D, Linch DC, Goldstone AH (1996). Successful CD34+ cell mobilisation is predictive of a survival advantage to patients with myeloma undergoing peripheral blood stem cell transplantation.. BRIT J HAEMATOL, 93, 302 - 302.
    • Mollapour E, Roberts PJ, Kaczmarski R, Porter JB, Linch DC (1996). Defective cytokine-mediated priming of neutrophil hydrogen peroxide production in sickle cell disease.. BRIT J HAEMATOL, 93, 333 - 333.
    • Chopra R, Kendall G, Gale RE, Thomas NS, Linch DC (1996). Expression of two alternatively spliced forms of the 5' untranslated region of the GM-CSF receptor alpha chain mRNA.. Exp Hematol, 24(6), 755 - 762.
    • Bernard T, Gale RE, Linch DC (1996). Analysis of granulocyte colony stimulating factor receptor isoforms, polymorphisms and mutations in normal haemopoietic cells and acute myeloid leukaemia blasts.. Br J Haematol, 93(3), 527 - 533.
    • Gale RE, Fielding AK, Linch DC (1996). Difficulties of using clonal analysis for diagnosis of haematological disorders in elderly patients. BRIT J HAEMATOL, 93, 787 - 787.
    • Watts MJ, Addison I, Sullivan AM, Chavda N, Jamieson E, Hunter M, Czaplewski L, Wood M, Linch DC (1996). Effects of a single dose at BB-10010 on progenitor cell mobilization after cyclophosphamide and G-CSF. BRIT J HAEMATOL, 93, 1049 - 1049.
    • Linch DC, Vaughan Hudson B, Hancock BW, Hoskin PJ, Cunningham DC, Newland AC, Milligan DW, Stevenson PA, Wood JK, MacLennan KA, Anderson L, Gregory WM, Vaughan Hudson G (1996). A randomised comparison of a third-generation regimen (PACEBOM) with a standard regimen (CHOP) in patients with histologically aggressive non-Hodgkin's lymphoma: a British National Lymphoma Investigation report.. British Journal of Cancer, 74(2), 318 - 322.
    • Hill ME, MacLennan KA, Cunningham DC, Vaughan Hudson B, Burke M, Clarke P, Di Stefano F, Anderson L, Vaughan Hudson G, Mason D, Selby P, Linch DC (1996). Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study.. Blood, 88(3), 1046 - 1051.
    • Jamal R, Gale RE, Shaun N, Thomas B, Wheatley K, Linch DC (1996). The retinoblastoma gene (rb1) in acute myeloid leukaemia: analysis of gene rearrangements, protein expression and comparison of disease outcome.. Br J Haematol, 94(2), 342 - 351.
    • Fielding AK, Goldstone AH, Sullivan AM, Watts MJ, Jamieson E, Linch DC (1996). Peripheral blood stem cell support does not accelerate haemopoietic recovery from miniBEAM chemotherapy.. Bone Marrow Transplant, 18(3), 507 - 511.
    • Wheadon H, Roberts PJ, Linch DC (1996). Differentiation-dependent changes in signal transduction mediated by the GM-CSF receptor.. BLOOD, 88(10), 784 - 784.
    • Roberts PJ, Mollapour E, Linch DC (1996). Regulation of phospholipase A(2) (PLA(2)) during differentiation of haemopoietic stem cells.. BLOOD, 88(10), 790 - 790.
    • Peniket AJ, Hudson GV, Anderson L, Linch DC (1996). Chronic relapsing Hodgkin's disease: An analysis of 167 cases from the British national lymphoma (BNLI) database.. BLOOD, 88(10), 892 - 892.
    • Fidler C, Mills KI, Frodsham PM, Kusec R, Gaiger A, Gale RE, Linch DC, Littlewood TJ, Moss PAH, Boultwood J, Wainscoat JS (1996). Amplification of mitochondrial DNA in CGL in transformation.. BLOOD, 88(10), 925 - 925.
    • Harrison CN, Hudson GV, Perry A, Anderson L, MacMillan A, Devereux S, Goldstone AH, Linch DC (1996). Beam and ABMT/PBSCT may reduce the risk of secondary leukaemia in Hodgkin's disease: A case-control analysis with the BNLI database.. BLOOD, 88(10), 1036 - 1036.
    • Watts MJ, Addison I, Linch DC (1996). Comparison of progenitor cell mobilisation by glycosylated and non-glycosylated G-CSF given at a dose of 5 mu g/kg/day to normal volunteers.. BLOOD, 88(10), 1570 - 1570.
    • Watts MJ, Leverett D, Sullivan AM, Peniket AJ, Perry AR, MacMillan A, Goldstone AH, Linch DC (1996). A comparison of ESHAP+G-CSF vs cyclophosphamide 1.5g/m(2)+G-CSF for PBSC mobilisation in pre-treated lymphoma patients: A matched pair analysis.. BLOOD, 88(10), 1571 - 1571.
    • Yong KL, Watts MJ, Thomas NSB, Sullivan AM, Williams C, Masek L, Sweetenham J, Linch DC (1996). Transendothelial migration of CD34+ cells requires prior activation by growth factors and is mediated by PECAM-1.. BLOOD, 88(10), 1888 - 1888.
    • Sweetenham JW, Taghipour G, Linch DC, Goldstone AH (1996). Thirty percent of adult patients with primary refractory Hodgkin's disease (HD) are progression free at 5 years after high dose therapy (HDT) and autologous stem cell transplantation (ASCT): Data from 290 patients reported to the EBMT.. BLOOD, 88(10), 1932 - 1932.
    • Bernard T, Evans JPM, Sullivan AM, Gale RE, Linch DC (1996). Mutations of the granulocyte colony-stimulating factor receptor in Kostmann's syndrome may be transient and may not herald leukaemic transformation.. BLOOD, 88(10), 2177 - 2177.
    • Freeburn RW, Gale RE, Linch DC (1996). The beta chain of the GM-CSF receptor can dimerize in the absence of specific alpha chains and ligand. BLOOD, 88(10), 2635 - 2635.
    • Linch DC (1996). Management of the histologically aggressive non-Hodgkin's lymphomas in adults.. Baillière's Clinical Haematology, 9(4), 689 - 706.
    • Perry AR, Linch DC (1996). The history of bone-marrow transplantation.. Blood Reviews, 10(4), 215 - 219.
    • Linch DC (1996). Non-Hodgkin's lymphomas - Preface. BAILLIERE CLIN HAEM, 9(4), R9 - R9.
    • Linch DC (1996). Intensive chemotherapy and bone marrow transplantation: The challenge of fungal infections - Proceedings of a satellite symposium to the 21st annual meeting of the European Group for Blood and Marrow Transplantation (EBMT), held in Davos, Switzerland on 19 March 1995 - Introduction. EUR J HAEMATOL, 56, 5 - 6.

    1995

    • Khwaja A, Goldstone AH, Linch DC (1995). Delayed neutrophil recovery after BEAM chemotherapy and autologous bone marrow transplantation for lymphoma is not associated with increased mortality from infection.. Bone Marrow Transplant, 15(2), 313 - 315.
    • Mills W, Chopra R, McMillan A, Pearce R, Linch DC, Goldstone AH (1995). BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin's lymphoma.. Journal of Clinical Oncology, 13(3), 588 - 595.
    • Mills W, Strang J, Goldstone AH, Linch DC (1995). Dose intensification of etoposide in the BEAM ABMT protocol for malignant lymphoma.. Leukemia and Lymphoma, 17(3), 263 - 270.
    • TEDDER RS, ZUCKERMAN MA, GOLDSTONE AH, HAWKINS AE, FIELDING A, BRIGGS EM, IRWIN D, BLAIR S, GORMAN AM, PATTERSON KG, LINCH DC, HEPTONSTALL J, BRINK NS (1995). HEPATITIS-B TRANSMISSION FROM CONTAMINATED CRYOPRESERVATION TANK. LANCET, 346(8968), 137 - 140.
    • Williams CD, Sorensen TS, LaThangue NB, Linch DC, Thomas NSB (1995). Analysis of the transcription factor, DP-1, in acute myeloid leukemia shows no functional abnormalities. BLOOD, 86(10), 2974 - 2974.
    • Linch DC, Milligan DW, Winfield DA, Kelsey S, Johnson S, Littlewood T, Smith G, Hutchinson MR, Goldstone AH, Fielding A, Williams M, Hartley S, Long SG (1995). G-CSF significantly accelerates neutrophil recovery after peripheral blood stem cell transplantation (PBSCT) in lymphoma patients and shortens the time in hospital; Preliminary results of a randomised BNLI trial.. BLOOD, 86(10), 873 - 873.
    • Watts MJ, Sullivan AM, Jamieson E, Fielding A, Pearce RM, Goldstone AH, Linch DC (1995). Adequacy of stem cell collection in relapsed and resistant lymphomas mobilised with cyclophosphamide 1.5 g/m(2) and G-CSF. BLOOD, 86(10), 1621 - 1621.
    • Fielding AK, Gale RE, Linch DC (1995). Analysis of X chromosome inactivation patterns in the elderly; Implications for stem cell usage.. BLOOD, 86(10), 2347 - 2347.
    • Watts MJ, Jones HM, Sullivan AM, Langabeer SE, Jamieson E, Fielding A, Williams C, Berenson RJ, Goldstone AH, Linch DC (1995). Accessory cells do not contribute to G-CSF or IL-6 production nor to rapid haematological recovery following peripheral blood stem cell transplantation.. Br J Haematol, 91(3), 767 - 772.

    1994

    • Vaughan Hudson B, Vaughan Hudson G, Linch DC, Anderson L (1994). Late mortality in young BNLI patients cured of Hodgkin's disease.. Annals of Oncology, 5(2), 65 - 66.
    • LINCH DC, FINE LG, FIELDING A, MACHIN SJ, GOLDSTONE AH, SOLOMON E, GANN A (1994). ACUTE PROMYELOCYTIC LEUKEMIA. LANCET, 344(8937), 1615 - 1618.
    • Mills W, Chopra R, Linch DC, Goldstone AH (1994). Liposomal amphotericin B in the treatment of fungal infections in neutropenic patients: a single-centre experience of 133 episodes in 116 patients.. British Journal of Haematology, 86(4), 754 - 760.
    • Linch DC (1994). Management of histologically aggressive non-Hodgkin's lymphomas.. British Journal of Haematology, 86(4), 691 - 694.
    • Gale RE, Wheadon H, Boulos P, Linch DC (1994). Tissue specificity of X-chromosome inactivation patterns.. Blood, 83(10), 2899 - 2905.
    • Vaughan Hudson B, Vaughan Hudson G, MacLennan KA, Anderson L, Linch DC (1994). Clinical stage 1 non-Hodgkin's lymphoma: long-term follow-up of patients treated by the British National Lymphoma Investigation with radiotherapy alone as initial therapy.. British Journal of Cancer, 69(6), 1088 - 1093.
    • Jones HM, Nathrath M, Thomas RM, Edelman P, Rodeck CH, Linch DC (1994). The effects of gestation on circulating progenitor cells.. British Journal of Haematology, 87(3), 637 - 639.
    • Jaswon MS, Jones HM, Linch DC (1994). The effects of recombinant human granulocyte-macrophage colony stimulating factor on the neutrophil respiratory burst in the term and preterm infant when studied in whole blood.. Pediatric Research, 36(5), 623 - 627.
    • SCHMITZ N, LINCH DC, DREGER P, BOOGAERTS MA, GOLDSTONE AH, FERRANT A, DEMUYNCK HMS, LINK H, ZANDER A, MATCHAM J, BORKETT KM, SCHWAB G (1994). A RANDOMIZED PHASE-III STUDY OF FILGRAMSTIM-MOBILIZED PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANTATION (PBPCT) IN COMPARISON WITH AUTOLOGOUS BONE-MARROW TRANSPLANTATION (ABMT) IN PATIENTS WITH HODGKINS-DISEASE (HD) AND NON-HODGKINS-LYMPHOMA (NHL). BLOOD, 84(10), A204 - A204.
    • Khwaja A, Linch DC (1994). Haemopoietic growth factors in the treatment of infection in non-neutropenic patients.. J Antimicrob Chemother, 33(4), 679 - 683.
    • Hancock BW, Vaughan Hudson G, Vaughan Hudson B, Linch DC, Anderson L, MacLennan KA (1994). Hybrid LOPP/EVA is not better than LOPP alternating with EVAP: a prematurely terminated British National Lymphoma Investigation randomized trial.. Annals of Oncology, 5(2), 117 - 120.
    • Linch DC (1994). Dose optimisation and dose intensification in malignant lymphoma.. European Journal of Cancer, 30(1), 122 - 125.
    • Linch DC (1994). Evaluation of haematopoietic growth factors: defining relevant clinical endpoints in growth factor trials.. European Journal of Cancer, 30(3), S40 - S43.
    • Gale RE, Linch DC (1994). Investigation of methylation at Hha I sites using the hypervariable probe M27 beta allows improved clonal analysis in myeloid leukaemia and demonstrates differences in methylation between leukaemic and remission samples.. Leukemia, 8(1), 190 - 194.
    • ROBERTS PJ, PIZZEY AR, LINCH DC (1994). REGULATION OF PHOSPHOLIPASE-A2 BY GM-CSF. J CELL BIOCHEM, , 52 - 52.
    • YONG KL, MCNALLY T, MACKIE IJ, COHEN H, MACHIN SJ, LINCH DC (1994). GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) INCREASES PLASMA FIBRINOLYTIC-ACTIVITY IN-VIVO. FIBRINOLYSIS, 8(1), 42 - 47.
    • Grimwade DJ, Chopra R, King A, Shaw P, Pearce R, Linch DC, Goldstone AH (1994). Detection and significance of pulmonary Hodgkin's disease at autologous bone marrow transplantation.. Bone Marrow Transplantation, 13(2), 173 - 179.
    • HUDSON BV, HUDSON GV, LINCH DC, ANDERSON L (1994). LATE MORTALITY IN YOUNG BNLI PATIENTS CURED OF HODGKINS-DISEASE. ANN ONCOL, 5, S65 - S66.
    • HANCOCK BW, HUDSON GV, HUDSON BV, LINCH DC, ANDERSON L, MACLENNAN KA (1994). HYBRID LOPP EVA IS NOT BETTER THAN LOPP ALTERNATING WITH EVAP - A PREMATURELY TERMINATED BRITISH NATIONAL LYMPHOMA INVESTIGATION RANDOMIZED TRIAL. ANN ONCOL, 5, S117 - S120.
    • Salooja N, Chatterjee R, McMillan AK, Kelsey SM, Newland AC, Milligan DW, Franklin IM, Hutchinson RM, Linch DC, Goldstone AH (1994). Successful pregnancies in women following single autotransplant for acute myeloid leukemia with a chemotherapy ablation protocol.. Bone Marrow Transplantation, 13(4), 431 - 435.
    • Khwaja A, Linch DC (1994). Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on neutrophil formation and function.. Curr Opin Hematol, 1(3), 216 - 220.
    • Chopra R, Wotherspoon AC, Blair S, McMillan AK, Mills W, Fielding AK, Linch DC, Goldstone AH (1994). Detection and significance of bone marrow infiltration at the time of autologous bone marrow transplantation in Hodgkin's disease.. Br J Haematol, 87(3), 647 - 649.
    • Jones HM, Jones SA, Watts MJ, Khwaja A, Mills W, Fielding A, Goldstone AH, Linch DC (1994). Development of a simplified single-apheresis approach for peripheral-blood progenitor-cell transplantation in previously treated patients with lymphoma.. J Clin Oncol, 12(8), 1693 - 1702.
    • Roberts PJ, Khwaja A, Lie AK, Bybee A, Yong K, Thomas NS, Linch DC (1994). Differentiation-linked changes in tyrosine phosphorylation, functional activity, and gene expression downstream from the granulocyte-macrophage colony-stimulating factor receptor.. Blood, 84(4), 1064 - 1073.
    • GALE RE, LINCH DC (1994). LINEAGE INVOLVEMENT IN CHRONIC MYELOPROLIFERATIVE DISORDERS. BRIT J HAEMATOL, 87(4), 882 - 882.
    • Mills W, Chatterjee R, McGarrigle HH, Linch DC, Goldstone AH (1994). Partial hypopituitarism following total body irradiation in adult patients with haematological malignancy.. Bone Marrow Transplantation, 14(3), 471 - 473.
    • Wagner HM, Gale RE, Freeburn RW, Devereux S, Linch DC (1994). Analysis of mutations in the GM-CSF receptor alpha coding sequence in patients with acute myeloid leukaemia and haematologically normal individuals by RT-PCR-SSCP.. Leukemia, 8(9), 1527 - 1532.
    • Gale RE, Linch DC (1994). Interpretation of X-chromosome inactivation patterns.. Blood, 84(7), 2376 - 2378.
    • Khwaja A, Addison IE, Johnson B, Yong K, Linch DC (1994). Interleukin-3 administration enhances human monocyte function in vivo.. Br J Haematol, 88(3), 515 - 519.
    • LINCH DC, VAUGHAN HG, VAUGHAN HB, ANDERSON L (1994). PACEBOM IS SUPERIOR TO CHOP IN PATIENTS WITH STAGE-IV HISTOLOGICALLY AGGRESSIVE NON-HODGKINS-LYMPHOMA [NHL] - RESULTS OF A BRITISH NATIONAL LYMPHOMA INVESTIGATION [BNLI] TRIAL. BLOOD, 84(10), A384 - A384.
    • Gisselbrecht C, Prentice HG, Bacigalupo A, Biron P, Milpied N, Rubie H, Cunningham D, Legros M, Pico JL, Linch DC, et AL (1994). Placebo-controlled phase III trial of lenograstim in bone-marrow transplantation.. The Lancet, 343(8899), 696 - 700.

    1993

    • Bradley SJ, Hudson GV, Linch DC (1993). Idiopathic thrombocytopenic purpura in Hodgkin's disease: a report of eight cases.. Clinical Oncology, 5(6), 355 - 357.
    • BRINK NS, MILLS W, CHOPRA R, GARSON JA, PERRONS CJ, DEAVILLE RC, WAITE J, GOLDSTONE AH, LINCH DC, TEDDER RS (1993). EFFICACY OF DONOR SCREENING FOR HEPATITIS-C ANTIBODIES IN PREVENTING HEPATITIS-C INFECTION IN MULTIPLY TRANSFUSED PATIENTS. TRANSFUSION MED, 3(4), 291 - 294.
    • KHWAJA A, CARVER J, JONES HM, PATTERSON D, LINCH DC (1993). EXPRESSION AND DYNAMIC MODULATION OF THE HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) RECEPTOR IN IMMATURE AND DIFFERENTIATED MYELOID CELLS. BRIT J HAEMATOL, 84, 21 - 21.
    • GALE RE, WHEADON H, BOULOS P, LINCH DC (1993). TISSUE-SPECIFICITY OF X-CHROMOSOME INACTIVATION PATTERNS. BRIT J HAEMATOL, 84, 59 - 59.
    • Brink NS, Chopra R, Perrons CJ, Ring CJ, Garson JA, Briggs EM, Goldstone AH, Linch DC, Tedder RS (1993). Acute hepatitis C infection in patients undergoing therapy for haematological malignancies: a clinical and virological study.. British Journal of Haematology, 83(3), 498 - 503.
    • Linch DC, Scarffe H, Proctor S, Chopra R, Taylor PR, Morgenstern G, Cunningham D, Burnett AK, Cawley JC, Franklin IM, et AL (1993). Randomised vehicle-controlled dose-finding study of glycosylated recombinant human granulocyte colony-stimulating factor after bone marrow transplantation.. Bone Marrow Transplantation, 11(4), 307 - 311.
    • GISSELBRECHT C, PRENTICE G, BACIGALUPO A, BIRON P, MILPIED N, RUBIE H, CUNNINGHAM D, LEGROS M, PICO JL, LINCH DC, BURNETT AK, SCARFFE JH, SIEGERT W, YVER A (1993). A PHASE-III RANDOMIZED PLACEBO-CONTROLED STUDY IN 315 PEDIATRIC AND ADULT AUTOLOGOUS OR ALLOGENEIC BONE-MARROW TRANSPLANTATION WITH LENOGRASTIM-5 UG/KG/DAY (GLYCOSYLATED RHU-G-CSF). BLOOD, 82(10), A455 - A455.
    • YONG K, CAVENAGH J, ROBERTS PJ, HOFFBRAND AV, LINCH DC (1993). MYELOID DIFFERENTIATION IS ASSOCIATED WITH INCREASED TRANSENDOTHELIAL MIGRATION - STUDIES IN HL-60 CELLS. BLOOD, 82(10), A515 - A515.
    • Linch DC, Winfield D, Goldstone AH, Moir D, Hancock B, McMillan A, Chopra R, Milligan D, Hudson GV (1993). Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial.. The Lancet, 341(8852), 1051 - 1054.
    • Roberts PJ, Yong KL, Khwaja A, Johnson BV, Pizzey AR, Carver JE, Addison IE, Linch DC (1993). Pentoxifylline at clinically achievable levels inhibits FMLP-induced neutrophil responses, but not priming, upregulation of cell-adhesion molecules, or migration induced by GM-CSF.. , , - .
    • Roberts PJ, Pizzey AR, Khwaja A, Carver JE, Mire-Sluis AR, Linch DC (1993). The effects of interleukin-8 on neutrophil fMetLeuPhe receptors, CD11b expression and metabolic activity, in comparison and combination with other cytokines.. , , - .
    • KHWAJA A, MILLS W, LEVERIDGE K, GOLDSTONE AH, LINCH DC (1993). EFFICACY OF DELAYED GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION (ABMT). BRIT J HAEMATOL, 84, 12 - 12.
    • JONES HM, JONES SA, KHWAJA A, WATTS M, MILLS W, GOLDSTONE AH, LINCH DC (1993). CRITICAL ANALYSIS OF THE PARAMETERS USED FOR MONITORING PERIPHERAL-BLOOD STEM-CELL (PBSC) HARVESTING. BRIT J HAEMATOL, 84, 12 - 12.
    • Roberts PJ, Pizzey AR, Linch DC (1993). The effect of inhibition of leukotriene synthesis on the activity of interleukin-8 and granulocyte-macrophage colony-stimulating factor.. Mediators Inflamm, 2(3), 211 - 216. doi:10.1155/S0962935193000286
    • WAGNER HM, GALE RE, DEVEREUX S, FREEBURN RW, LINCH DC (1993). ANALYSIS OF MUTATIONS IN THE GM-CSF RECEPTOR-ALPHA GENE IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA. BRIT J HAEMATOL, 84, 6 - 6.
    • KHWAJA A, JOHNSON B, ADDISON IE, YONG K, CARVER J, LINCH DC (1993). INTERLEUKIN-3 (IL-3) INFUSIONS IN PATIENTS WITH MALIGNANT-LYMPHOMAS - PHARMACOKINETICS AND ACUTE EFFECTS ON CIRCULATING LEUKOCYTE NUMBERS AND MONOCYTE FUNCTION. BRIT J HAEMATOL, 84, 22 - 22.
    • MILLS W, STRANG J, CHOPRA R, LINCH DC, GOLDSTONE AH (1993). SUCCESSFUL TREATMENT WITH AMBISOME OF PROVEN ASPERGILLUS INFECTION COMPLICATING NEUTROPENIA. BRIT J HAEMATOL, 84, 32 - 32.
    • CHATTERJEE R, MILLS W, KATZ M, MCGORRIGLE HHG, LINCH DC, GOLDSTONE AH (1993). EVALUATION OF SHORT AND LONG-TERM EFFECTS OF TBI VS BEAM ON HYPOTHALAMIC-PITUITARY-GONADAL (HPG) AXIS IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES. BRIT J HAEMATOL, 84, 52 - 52.
    • FIELDING AK, MCMILLAN AK, CHOPRA R, TOBIAS JS, LINCH DC, GOLDSTONE AH (1993). FEASIBILITY OF RADIOTHERAPY AS CONSOLIDATION POST BEAM AUTOGRAFT FOR HODGKINS-DISEASE. BRIT J HAEMATOL, 84, 53 - 53.
    • POLLARD Y, JONES S, CARTER AB, GOLDSTONE AH, LINCH DC, MACHIN SJ (1993). AUTOMATED RETICULOCYTE COUNTS WITH RNA QUANTIFICATION TO MONITOR STEM-CELL TRANSPLANTATION. BRIT J HAEMATOL, 84, 61 - 61.
    • KHWAJA A, CARVER J, JONES HM, DEVEREUX S, THORPE R, LINCH DC (1993). MODULATION OF SURFACE EXPRESSION OF THE HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) RECEPTOR. BRIT J HAEMATOL, 84, 67 - 67.
    • Gale RE, Wheadon H, Goldstone AH, Burnett AK, Linch DC (1993). Frequency of clonal remission in acute myeloid leukaemia.. The Lancet, 341(8838), 138 - 142.
    • Chopra R, McMillan AK, Linch DC, Yuklea S, Taghipour G, Pearce R, Patterson KG, Goldstone AH (1993). The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. A single-center eight-year study of 155 patients.. Blood, 81(5), 1137 - 1145.
    • Yong KL, Linch DC (1993). Granulocyte-macrophage-colony-stimulating factor differentially regulates neutrophil migration across IL-1-activated and nonactivated human endothelium.. J Immunol, 150(6), 2449 - 2456.
    • LINCH DC (1993). HEMATOPOIETIC GROWTH-FACTORS - REVIEW LECTURE.
    • Khwaja A, Mills W, Leveridge K, Goldstone AH, Linch DC (1993). Efficacy of delayed granulocyte colony-stimulating factor after autologous BMT.. Bone Marrow Transplant, 11(6), 479 - 482.
    • Khwaja A, Carver J, Jones HM, Linch DC (1993). Dynamic modulation of the cell surface expression of the granulocyte-macrophage colony-stimulating factor receptor.. Br J Haematol, 85(1), 42 - 49.
    • Khwaja A, Carver J, Jones HM, Paterson D, Linch DC (1993). Expression and dynamic modulation of the human granulocyte colony-stimulating factor receptor in immature and differentiated myeloid cells.. Br J Haematol, 85(2), 254 - 259.
    • GALE RE, CHOPRA R, FREEBURN RW, LINCH DC (1993). A TRUNCATED FORM OF THE BETA-COMMON CHAIN FOR THE HUMAN GM-CSF, IL3 AND IL5 RECEPTORS. BLOOD, 82(10), A184 - A184.
    • JONES HM, JONES SA, WATTS MJ, MILLS W, KHWAJA A, GOLDSTONE AH, LINCH DC (1993). THE EFFECTS OF VARIATION OF THE DOSE AND SCHEDULE OF G-CSF ADMINISTRATION AFTER LOW-DOSE CYCLOPHOSPHAMIDE (1.5 G/M(2) ON BOTH NEUTROPHIL AND PERIPHERAL-BLOOD HEMATOPOIETIC PROGENITOR-CELL LEVELS. BLOOD, 82(10), A233 - A233.
    • KHWAJA A, LINCH DC (1993). DIFFERENTIAL RECEPTOR MODULATION AND SIGNALING BY INTERLEUKIN-5 (IL-5) IN PRIMITIVE AND MATURE HUMAN MYELOID CELLS. BLOOD, 82(10), A367 - A367.
    • KHWAJA A, GOLDSTONE AH, LINCH DC (1993). PATIENTS WITH DELAYED NEUTROPHIL RECOVERY AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION (ABMT) FOR LYMPHOMA NOT RECEIVING HEMATOPOIETIC GROWTH-FACTORS DO NOT HAVE INCREASED MORTALITY FROM INFECTION. BLOOD, 82(10), A424 - A424.
    • DEVEREUX S, WAGNER HM, KHWAJA A, MCMILLAN AK, LINCH DC (1993). A NOVEL ISOFORM OF THE LOW-AFFINITY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR. BRIT J HAEMATOL, 84, 21 - 21.

    1992

    • Sherwood RA, Brent L, Linch DC (1992). The role of hemopoietic stem cells and accessory cells in tolerance induction.. Transplantation, 53(5), 1161 - 1162.
    • Yong KL, Linch DC (1992). Differential effects of granulocyte- and granulocyte-macrophage colony-stimulating factors (G- and GM-CSF) on neutrophil adhesion in vitro and in vivo.. Eur J Haematol, 49(5), 251 - 259.
    • Khwaja A, Linch DC (1992). Clinical applications of haemopoietic growth factors.. Leuk Lymphoma, 7 Suppl, 69 - 72. doi:10.3109/10428199209061569
    • Khwaja A, Carver JE, Linch DC (1992). Interactions of granulocyte-macrophage colony-stimulating factor (CSF), granulocyte CSF, and tumor necrosis factor alpha in the priming of the neutrophil respiratory burst.. Blood, 79(3), 745 - 753.
    • De Lord C, Newland AC, Linch DC, Vaughan Hudson B, Vaughan Hudson G (1992). Failure of IMVP-16 as second-line treatment for relapsed or refractory high grade non-Hodgkin's lymphoma.. Hematological Oncology, 10(2), 81 - 86.
    • Jones HM, Edelman P, Pilkington GR, Watts M, Linch DC (1992). Fc gamma RII, but not erythropoietin or GM-CSF, mediates calcium mobilization in fetal hemopoietic blast cells.. Experimental Hematology, 20(3), 315 - 319.
    • Chopra R, Linch DC, McMillan AK, Blair S, Patterson KG, Moir D, Richards JD, Cervi P, Kinsey S, Goldstone AH (1992). Mini-BEAM followed by BEAM and ABMT for very poor risk Hodgkin's disease.. British Journal of Haematology, 81(2), 197 - 202.
    • KHWAJA A, YONG K, JONES HM, CHOPRA R, MCMILLAN AK, GOLDSTONE AH, PATTERSON KG, MATHESON C, RUTHVEN K, ABRAMSON SB, LINCH DC (1992). THE EFFECT OF MACROPHAGE COLONY-STIMULATING FACTOR ON HEMATOPOIETIC RECOVERY AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION. BRIT J HAEMATOL, 81(2), 288 - 295.
    • Khwaja A, Choppa R, Goldstone AH, Linch DC (1992). Acute-phase response in patients given rhIL-3 after chemotherapy.. The Lancet, 339(8809), 1617 - .
    • Khwaja A, Linch DC, Goldstone AH, Chopra R, Marcus RE, Wimperis JZ, Russell NH, Haynes AP, Milligan DW, Leyland MJ (1992). Recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for malignant lymphoma: a British National Lymphoma Investigation double-blind, placebo-controlled trial.. Br J Haematol, 82(2), 317 - 323.
    • Devalia V, Thomas NS, Roberts PJ, Jones HM, Linch DC (1992). Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation.. Blood, 80(1), 68 - 76.
    • Gale RE, Wheadon H, Linch DC (1992). Assessment of X-chromosome inactivation patterns using the hypervariable probe M27 beta in normal hemopoietic cells and acute myeloid leukemic blasts.. Leukemia, 6(7), 649 - 655.
    • Hancock BW, Vaughan Hudson G, Vaughan Hudson B, Bennett MH, MacLennan KA, Haybittle JL, Anderson L, Linch DC (1992). LOPP alternating with EVAP is superior to LOPP alone in the initial treatment of advanced Hodgkin's disease: results of a British National Lymphoma Investigation trial.. Journal of Clinical Oncology, 10(8), 1252 - 1258.
    • LINCH DC (1992). CHUGAI-RHONE POULENC SYMPOSIUM - LENOGRASTIM, A NEW GLYCOSYLATED RHUG-CSF - PHARMACOLOGY AND CLINICAL PROFILE IN BONE-MARROW TRANSPLANTS. BRIT J HAEMATOL, 82(1), 276 - 277.
    • LINCH DC, HIDDEMANN W (1992). FARMITALIA-CARLO-ERBA SYMPOSIUM - IDARUBICIN IN HEMATOLOGICAL MALIGNANCIES. BRIT J HAEMATOL, 82(1), 279 - 279.
    • Yong KL, Rowles PM, Patterson KG, Linch DC (1992). Granulocyte-macrophage colony-stimulating factor induces neutrophil adhesion to pulmonary vascular endothelium in vivo: role of beta 2 integrins.. Blood, 80(6), 1565 - 1575.
    • Yong K, Salooja N, Donahue RE, Hegde U, Linch DC (1992). Human macrophage colony-stimulating factor levels are elevated in pregnancy and in immune thrombocytopenia.. Blood, 80(11), 2897 - 2902.
    • McMillan A, Pearce R, Chopra R, Goldstone AH, Linch DC (1992). Treatment of Hodgkin's lymphoma.. BMJ (Clinical Research Ed.), 305(6849), 367 - .

    1991

    • Roberts PJ, Devalia V, Faint R, Pizzey A, Bainton AL, Thomas NS, Pilkington GR, Linch DC (1991). Differentiation-linked activation of the respiratory burst in a monocytic cell line (U937) via Fc gamma RII. A study of activation pathways and their regulation. , , - .
    • Khwaja A, Johnson B, Addison IE, Yong K, Ruthven K, Abramson S, Linch DC (1991). In vivo effects of macrophage colony-stimulating factor on human monocyte function.. Br J Haematol, 77(1), 25 - 31.
    • LIM SH, MCMILLAN AK, CHOPRA RAJ, KINSEY SE, CERVI P, SALOOJA N, SMITH MP, HOLTON J, LINCH DC, GOLDSTONE AH (1991). TRANSPLANT RELATED SEPTICEMIA IN PATIENTS UNDERGOING AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR LYMPHOMA AND ACUTE-LEUKEMIA. LEUKEMIA LYMPHOMA, 5(2-3), 127 - 132.
    • Thomas NS, Burke LC, Bybee A, Linch DC (1991). The phosphorylation state of the retinoblastoma (RB) protein in G0/G1 is dependent on growth status.. Oncogene, 6(2), 317 - 322.
    • Gale RE, Wheadon H, Linch DC (1991). X-chromosome inactivation patterns using HPRT and PGK polymorphisms in haematologically normal and post-chemotherapy females.. Br J Haematol, 79(2), 193 - 197.
    • Thomas NS, Linch DC (1991). An intracellular 50-kDa Fc gamma-binding protein is induced in human cells by alpha-IFN.. The Journal of Immunology, 146(5), 1649 - 1654.
    • Yong K, Cohen H, Khwaja A, Jones HM, Linch DC (1991). Lack of effect of granulocyte-macrophage and granulocyte colony-stimulating factors on cultured human endothelial cells.. Blood, 77(8), 1675 - 1680.
    • YONG KY, SALOOJA N, HEGDE UM, DONAHUE RE, LINCH DC (1991). MACROPHAGE COLONY-STIMULATING FACTOR LEVELS IN IMMUNE THROMBOCYTOPENIC PURPURA (ITP) AND PREGNANCY. EXP HEMATOL, 19(6), 519 - 519.
    • KHWAJA A, JONES HM, YONG K, CHOPRA R, MACMILLAN A, GOLDSTONE AH, RUTHVEN K, ABRAMSON S, LINCH DC (1991). THE EFFECTS OF MACROPHAGE COLONY-STIMULATING FACTOR ON HEMATOLOGICAL RECOVERY FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANTATION. EXP HEMATOL, 19(6), 560 - 560.
    • Yong K, Addison IE, Johnson B, Webster AD, Linch DC (1991). Role of leucocyte integrins in phagocyte responses to granulocyte-macrophage colony stimulating factor (GM-CSF): in vitro and in vivo studies on leucocyte adhesion deficiency neutrophils.. Br J Haematol, 77(2), 150 - 157.

    1990

    • GOLDSTONE AH, MCMILLAN AK, LINCH DC (1990). WHAT IS THE VALUE OF HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION (ABMT) IN THE TREATMENT OF ACUTE MYELOID-LEUKEMIA (AML) IN 1ST AND 2ND REMISSION.
    • Devereux S, Linch DC (1990). Granulocyte-macrophage colony-stimulating factor.. Biotherapy, 2(4), 305 - 313.
    • MCMILLAN AK, GRIBBEN JG, TOBIAS JS, LINCH DC, GOLDSTONE AH (1990). RADIOTHERAPY AFTER INTENSIVE CHEMOTHERAPY AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR RESISTANT HODGKINS-DISEASE. BRIT J CANCER, 61(1), 168 - 168.
    • Macintyre EA, Roberts PJ, Abdul-Gaffar R, Morgan J, Linch DC (1990). Activation of monocytic cells by monoclonal antibodies to the CD11a/18 (LFA-1) complex: mediation by Fc receptor.. Immunology, 69(4), 574 - 579.
    • BRENT L, SHERWOOD RA, LINCH DC, GALE RE (1990). FAILURE OF EMBRYONIC MOUSE CELLS TO ENGRAFT IN IMMUNOCOMPETENT ALLOGENEIC RECIPIENTS. BRIT J HAEMATOL, 74(4), 549 - 550.
    • McMillan AK, Goldstone AH, Chopra R, Linch DC (1990). A comparison of the outcome of ABMT in first remission acute myeloid and lymphoblastic leukemia in a single centre.. Bone Marrow Transplantation, 6(1), 72 - .
    • Devereux S, Porter JB, Hoyes KP, Abeysinghe RD, Saib R, Linch DC (1990). Secretion of neutrophil secondary granules occurs during granulocyte-macrophage colony stimulating factor induced margination.. British Journal of Haematology, 74(1), 17 - 23.
    • Gribben JG, Devereux S, Thomas NS, Keim M, Jones HM, Goldstone AH, Linch DC (1990). Development of antibodies to unprotected glycosylation sites on recombinant human GM-CSF.. The Lancet, 335(8687), 434 - 437.
    • Jaswon MS, Khwaja A, Roberts PJ, Jones HM, Linch DC (1990). The effects of rhGM-CSF on the neutrophil respiratory burst when studied in whole blood.. Br J Haematol, 75(2), 181 - 187.
    • McMillan AK, Goldstone AH, Linch DC, Gribben JG, Patterson KG, Richards JD, Franklin I, Boughton BJ, Milligan DW, Leyland MM, et AL (1990). High-dose chemotherapy and autologous bone marrow transplantation in acute myeloid leukemia.. Blood, 76(3), 480 - 488.
    • Khwaja A, Roberts PJ, Jones HM, Yong K, Jaswon MS, Linch DC (1990). Isoquinolinesulfonamide protein kinase inhibitors H7 and H8 enhance the effects of granulocyte-macrophage colony-stimulating factor (GM-CSE) on neutrophil function and inhibit GM-CSF receptor internalization.. Blood, 76(5), 996 - 1003.
    • Brady HJ, Edwards M, Linch DC, Knott L, Barlow JH, Butterworth PH (1990). Expression of the human carbonic anhydrase I gene is activated late in fetal erythroid development and regulated by stage-specific trans-acting factors.. British Journal of Haematology, 76(1), 135 - 142.
    • Roberts PJ, Devereux S, Pilkington GR, Linch DC (1990). Fc gamma RII-mediated superoxide production by phagocytes is augmented by GM-CSF without a change in Fc gamma RII expression.. Journal of Leukocyte Biology, 48(3), 247 - 257.
    • Devereux S, Selassie TG, Vaughan Hudson G, Vaughan Hudson B, Linch DC (1990). Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation.. BMJ (Clinical Research Ed.), 301(6760), 1077 - 1080.
    • HUDSON GV, LINCH DC, HUDSON BV, BENNETT MH, MACLENNAN KA, ANDERSON L (1990). LONG-TERM FOLLOW UP OF BNLI STUDY OF CHOP CHEMOTHERAPY IN PATIENTS WITH ADVANCED HIGH-GRADE NON-HODGKINS LYMPHOMA. BRIT J CANCER, 61(1), 168 - 168.

    1989

    • Gribben JG, Goldstone AH, Linch DC, MacMillan AK, Richards JD (1989). Double autologous bone marrow transplantation in acute myeloid leukaemia.. Bone Marrow Transplantation, 4(1), 209 - 211.
    • Gribben JG, Goldstone AH, Linch DC, Taghipour G, McMillan AK, Souhami RL, Earl H, Richards JD (1989). Effectiveness of high-dose combination chemotherapy and autologous bone marrow transplantation for patients with non-Hodgkin's lymphomas who are still responsive to conventional-dose therapy.. Journal of Clinical Oncology, 7(11), 1621 - 1629.
    • Addison IE, Johnson B, Devereux S, Goldstone AH, Linch DC (1989). Granulocyte-macrophage colony-stimulating factor may inhibit neutrophil migration in vivo.. Clinical and Experimental Immunology, 76(2), 149 - 153.
    • Goldstone AH, Gribben JG, Linch DC (1989). Double autografting in first remission acute myeloid leukaemia.. Folia Haematologica: Internationales Magazin für Klinische und Morphologische Blutforschung, 116(3), 501 - 504.
    • Gray AG, Morgan J, Linch DC, Huehns ER (1989). Enhanced fluorescence in indirect immunophenotyping by the use of fluorescent liposomes.. Journal of Immunological Methods, 121(1), 1 - 7.
    • Linch DC, Brent L (1989). Marrow transplantation. Can cord blood be used?. Nature, 340(6236), 676 - .
    • Gribben JG, Goldstone AH, Linch DC (1989). Preliminary results of autologous bone marrow transplantation in the management of resistant Hodgkin's disease: experience of the Bloomsbury Transplant Group at University College, London.. Recent Results in Cancer Research, 117, 242 - 245.
    • Devereaux S, Linch DC, Gribben JG, McMillan A, Patterson K, Goldstone AH (1989). GM-CSF accelerates neutrophil recovery after autologous bone marrow transplantation for Hodgkin's disease.. Bone Marrow Transplantation, 4(1), 49 - 54.
    • Devereux S, Linch DC (1989). Clinical significance of the haemopoietic growth factors.. British Journal of Cancer, 59(1), 2 - 5.
    • Devereux S, Bull HA, Campos-Costa D, Saib R, Linch DC (1989). Granulocyte macrophage colony stimulating factor induced changes in cellular adhesion molecule expression and adhesion to endothelium: in-vitro and in-vivo studies in man.. British Journal of Haematology, 71(3), 323 - 330.
    • Macintyre EA, Wallace DW, O'Flynn K, Abdul-Gaffar R, Tetteroo PA, Morgan G, Linch DC (1989). Binding of monoclonal antibody to CD16 causes calcium mobilization in large granular lymphocytes but inhibits NK killing.. Immunology, 66(3), 459 - 465.
    • Brent L, Linch DC, Rodeck CH, Nicolaides K, DeGiorgi L, Sherwood RA, al-Imara L, Mew J, Socha W (1989). On the feasibility of inducing tolerance in man: a study in the cynomolgus monkey.. Immunology Letters, 21(1), 55 - 61.
    • MacIntyre EA, Roberts PJ, Jones M, Van der Schoot CE, Favalaro EJ, Tidman N, Linch DC (1989). Activation of human monocytes occurs on cross-linking monocytic antigens to an Fc receptor.. The Journal of Immunology, 142(7), 2377 - 2383.
    • Schey S, Vaughan Hudson B, Linch DC, Bennett MH, MacLennan KA, Jelliffe AM, Vaughan Hudson G (1989). The prognostic influence of mediastinal bulk in pathological stage IIA Hodgkin's disease treated initially with radiotherapy.. Clinical Oncology, 1(1), 28 - 32.
    • Linch DC (1989). The regulation of erythropoiesis in man.. Schweizerische Medizinische Wochenschrift, 119(39), 1327 - 1328.
    • Roberts PJ, Cummins D, Bainton AL, Walshe KJ, Fisher-Hoch SP, McCormick JB, Gribben JG, Machin SJ, Linch DC (1989). Plasma from patients with severe Lassa fever profoundly modulates f-met-leu-phe induced superoxide generation in neutrophils.. British Journal of Haematology, 73(2), 152 - 157.
    • Gribben JG, Linch DC, Singer CR, McMillan AK, Jarrett M, Goldstone AH (1989). Successful treatment of refractory Hodgkin's disease by high-dose combination chemotherapy and autologous bone marrow transplantation.. Blood, 73(1), 340 - 344.

    1988

    • Macintyre EA, Linch DC (1988). Lymphocytosis: is it leukaemia and when to treat.. Postgraduate Medical Journal, 64(747), 42 - 47.
    • GOLDSTONE AH, LINCH DC, GRIBBEN JG, MCMILLAN A (1988). EXPERIENCE OF AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN THE 1ST 100 LYMPHOMAS. BONE MARROW TRANSPL, 3, 65 - 66.
    • DEVEREUX S, MACMILLAN A, GRIBBEN J, PATTERSON K, GOLDSTONE AH, LINCH DC (1988). PHASE-I PHASE-II STUDIES OF RH GM-CSF AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN HODGKINS-DISEASE. BONE MARROW TRANSPL, 3, 91 - 91.
    • DEVEREUX S, COSTA DC, GRIBBEN J, SPITTLE MF, JELLIFFE AM, GOLDSTONE AH, LINCH DC (1988). PRELIMINARY STUDIES OF RECOMBINANT GM-CSF IN MAN. BRIT J CANCER, 57(2), 231 - 231.
    • Singer CR, Linch DC, Bown SG, Huehns ER, Goldstone AH (1988). Differential phthalocyanine photosensitization of acute myeloblastic leukaemia progenitor cells: a potential purging technique for autologous bone marrow transplantation.. Br J Haematol, 68(4), 417 - 422.
    • Gray AG, Morgan J, Linch DC, Huehns ER (1988). Uptake of antibody directed cytotoxic liposomes by CD3 on human T cells.. Clinical and Experimental Immunology, 72(1), 168 - 173.
    • MacIntyre EA, Roberts PJ, Abdul-Gaffar R, O'Flynn K, Pilkington GR, Farace F, Morgan J, Linch DC (1988). Mechanism of human monocyte activation via the 40-kDa Fc receptor for IgG.. The Journal of Immunology, 141(12), 4333 - 4343.
    • DEVEREUX S, GOLDSTONE AH, PATTERSON K, LINCH DC (1988). THE USE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR TO ACCELERATE RECOVERY OF THE AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN MAN. BRIT J HAEMATOL, 69(1), 103 - 103.
    • MATTOCK C, SINGER CRJ, LINCH DC (1988). SUPPRESSION OF CFU-GM AT THERAPEUTIC LEVELS OF H-2-ANTAGONISTS. BRIT J HAEMATOL, 69(1), 113 - 113.
    • ROBERTS PJ, MACINTYRE EA, LINCH DC (1988). PRIMING BY DELTA-INTERFERON IS REQUIRED FOR THE ACTIVATION OF HUMAN-MONOCYTES VIA FCRII. BRIT J HAEMATOL, 69(1), 145 - 145.
    • Macintyre EA, Tatham PE, Abdul-Gaffar R, Linch DC (1988). The effects of pertussis toxin on human T lymphocytes.. Immunology, 64(3), 427 - 432.
    • Linch DC, Devereux S, Addison IE (1988). The effects of recombinant human granulocyte-macrophage colony-stimulating factor on phagocyte kinetics in man.. Behring Inst Mitt, (83), 320 - 323.
    • DEVEREUX S, PORTER JB, ADDISON IE, BULL HE, DOWD P, LINCH DC (1988). THE MECHANISM OF GM-CSF INDUCED NEUTROPENIA. BRIT J HAEMATOL, 68(4), 507 - 507.

    1987

    • Anderson CC, Goldstone AH, Linch DC, Jones HM, Franklin IM, Boughton BJ, Cawley JC, Richards JD (1987). Autologous bone marrow transplantation for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia--a comparison.. Bone Marrow Transplantation, 1(3), 271 - 279.
    • Devereux S, Linch DC, Campos Costa D, Spittle MF, Jelliffe AM (1987). Transient leucopenia induced by granulocyte-macrophage colony-stimulating factor.. The Lancet, 2(8574), 1523 - 1524.
    • Yardumian DA, O'Flynn K, Linch DC, Machin SJ (1987). Interactions between prostacyclin analogue ZK 36374 and heparin in their effects upon platelet function.. British Journal of Haematology, 65(3), 325 - 330.
    • Linch DC, Goldstone AH (1987). Autologous bone marrow transplantation in acute leukaemia.. Bone Marrow Transplantation, 2(3), 219 - 225.
    • GRIBBEN JG, GOLDSTONE AH, LINCH DC, RICHARDS JDM, DONES L (1987). AUTOLOGOUS BONE-MARROW TRANSPLANTATION (ABMT) IN ACUTE-LEUKEMIA. BRIT J CANCER, 56(6), 871 - 872.
    • Beverley PC, Wallace DL, O'Flynn K, Linch DC (1987). Early events in lymphocyte activation triggered via CD3/Ti or CD2.. Advances in Experimental Medicine and Biology, 213, 51 - 58.
    • Singer CR, Linch DC (1987). Comparison of the sensitivity of normal and leukaemic myeloid progenitors to in-vitro incubation with cytotoxic drugs: a study of pharmacological purging.. Leukemia Research, 11(11), 953 - 959.
    • Bowcock SJ, Linch DC, Machin SJ, Stewart JW (1987). Pyrimethamine in the myeloproliferative disorders: a forgotten treatment?. Clinical and Laboratory Haematology, 9(2), 129 - 136.
    • Vaughan Hudson B, Linch DC, Macintyre EA, Bennett MH, MacLennan KA, Vaughan Hudson G, Jelliffe AM (1987). Selective peripheral blood eosinophilia associated with survival advantage in Hodgkin's disease (BNLI Report No 31). British National Lymphoma Investigation.. Journal of Clinical Pathology, 40(3), 247 - 250.
    • Macintyre EA, Vaughan Hudson B, Vaughan Hudson G, Jelliffe AM, Linch DC (1987). Incidence and clinical importance of bone marrow eosinophilia in Hodgkin's disease (BNLI Report No 29). British National Lymphoma Investigation.. Journal of Clinical Pathology, 40(3), 245 - 246.
    • MACINTYRE EA, HUDSON BV, HUDSON GV, JELLIFFE AM, LINCH DC (1987). INCIDENCE AND CLINICAL IMPORTANCE OF BONE-MARROW EOSINOPHILIA IN HODGKINS-DISEASE (BNLI REPORT NO-29). J CLIN PATHOL, 40(3), 245 - 246.
    • HUDSON BV, LINCH DC, MACINTYRE EA, BENNETT MH, MACLENNAN KA, HUDSON GV, JELLIFFE AM (1987). SELECTIVE PERIPHERAL-BLOOD EOSINOPHILIA ASSOCIATED WITH SURVIVAL ADVANTAGE IN HODGKINS-DISEASE (BNLI REPORT NO-31). J CLIN PATHOL, 40(3), 247 - 250.
    • Macintyre EA, Vaughan Hudson B, Linch DC, Vaughan Hudson G, Jelliffe AM (1987). The value of staging bone marrow trephine biopsy in Hodgkin's disease.. European Journal of Haematology, 39(1), 66 - 70.
    • SINGER CRJ, MORTON O, CHAPMAN S, LINCH DC (1987). THE INHIBITORY EFFECT OF DIPYRIDAMOLE ON CYTOSINE-ARABINOSIDE CYTOTOXICITY - A THERAPEUTICALLY USEFUL INTERACTION. BRIT J HAEMATOL, 66(4), 576 - 576.
    • Murphy MF, Metcalfe P, Waters AH, Carne CA, Weller IV, Linch DC, Smith A (1987). Incidence and mechanism of neutropenia and thrombocytopenia in patients with human immunodeficiency virus infection.. British Journal of Haematology, 66(3), 337 - 340.
    • Gribben JG, Vaughan Hudson B, Linch DC (1987). The potential value of very intensive therapy with autologous bone marrow rescue in the treatment of malignant lymphomas.. Hematological Oncology, 5(4), 281 - 293.
    • Singer CR, Bown SG, Linch DC, Huehns ER, Goldstone AH (1987). Phthalocyanine photosensitization for in vitro elimination of residual acute non-lymphoblastic leukaemia: preliminary evaluation.. Photochem Photobiol, 46(5), 745 - 749.
    • Dearden CE, Matutes E, Hoffbrand AV, Ganeshaguru K, Brozovic M, Williams HJ, Traub N, Mills M, Linch DC, Catovsky D (1987). Membrane phenotype and response to deoxycoformycin in mature T cell malignancies.. British Medical Journal (Clinical Research Ed.), 295(6603), 873 - 875.
    • GRIBBEN JG, GOLDSTONE AH, LINCH DC, SOUHAMI RL, VAUGHANHUDSON G, TOBIAS JS (1987). SALVAGE THERAPY IN RELAPSED HODGKINS-DISEASE BY HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION (ABMT) - OUTCOME AND INDICATIONS. BRIT J CANCER, 56(6), 872 - 872.
    • Linch DC, Wallace DL, O'Flynn K (1987). Signal transduction in human T lymphocytes.. Immunological Reviews, 95, 137 - 159.

    1986

    • Anderson CC, Goldstone AH, Souhami RL, Linch DC, Harper PG, McLennan KA, Jones M, Machin SJ, Jelliffe AM, Cawley JC, et AL (1986). Very high dose chemotherapy with autologous bone marrow rescue in adult patients with resistant relapsed lymphoma.. Cancer Chemotherapy and Pharmacology, 16(2), 170 - 175.
    • MACINTYRE EA, VAUGHANHUDSON B, VAUGHANHUDSON G, JELLIFFE AM, LINCH DC (1986). ROUTINE STAGING BONE-MARROW EXAMINATION IS NO LONGER INDICATED IN HODGKINS-DISEASE. BRIT J HAEMATOL, 64(4), 823 - 824.
    • OFLYNN K, KNOTT LJ, MORGAN G, BEVERLEY PCL, LINCH DC (1986). ACTIVATION OF LYMPHOCYTES-T THROUGH THE SHEEP RED-BLOOD-CELL RECEPTOR (CD2) IS INDEPENDENT OF THE ANTIGEN RECEPTOR CD3 COMPLEX. BRIT J HAEMATOL, 63(1), 203 - 203.
    • Alter BP, Weinberg RS, Linch DC, Schofield JM, Jackson BT, Piasecki GJ, Thornton JC, Nathan DG (1986). Investigations of the simian ontogenic switch from fetal to adult hemoglobin at the progenitor cell level.. Journal of Clinical Investigation, 78(6), 1497 - 1503.
    • Goldstone AH, Anderson CC, Linch DC, Franklin IM, Boughton BJ, Cawley JC, Richards JD (1986). Autologous bone marrow transplantation following high dose chemotherapy for the treatment of adult patients with acute myeloid leukaemia.. British Journal of Haematology, 64(3), 529 - 537.
    • Martin PJ, Anderson CC, Jones HM, Lai AP, Linch DC, Goldstone AH (1986). A rise in the percentage of large unstained cells in the peripheral blood determined by the Hemalog D90 automated differential counter is a feature of impending myeloid engraftment following bone marrow transplantation.. Clinical and Laboratory Haematology, 8(1), 1 - 8.
    • O'Flynn K, Knott LJ, Russul-Saib M, Abdul-Gaffar R, Morgan G, Beverley PC, Linch DC (1986). CD2 and CD3 antigens mobilize Ca2+ independently.. European Journal of Immunology, 16(5), 580 - 584.
    • Jones HM, Linch DC, Nicolaides K, Rodeck CH (1986). Survival of transfused adult cells in the fetus.. Fetal Therapy, 1(4), 193 - 195.
    • Linch DC, Rodeck CH, Nicolaides K, Jones HM, Brent L (1986). Attempted bone-marrow transplantation in a 17-week fetus.. The Lancet, 2(8521), 1453 - .
    • ANDERSON CC, LINCH DC, GOLDSTONE AH (1986). DOUBLE AUTOGRAFTING - A POTENTIAL CURATIVE REGIMEN FOR ACUTE-LEUKEMIA. LEUKEMIA RES, 10(1), 113 - 113.
    • Linch DC, Burnett AK (1986). Clinical studies of ABMT in acute myeloid leukaemia.. Clinics in Haematology, 15(1), 167 - 186.
    • Morgan G, Linch DC, Knott LT, Davies EG, Sieff C, Chessells JM, Hale G, Waldmann H, Levinsky RJ (1986). Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH-I monoclonal antibody and E-rosetting.. British Journal of Haematology, 62(3), 421 - 430.
    • Berliner N, Duby AD, Linch DC, Murre C, Quertermous T, Knott LJ, Azin T, Newland AC, Lewis DL, Galvin MC, et AL (1986). T cell receptor gene rearrangements define a monoclonal T cell proliferation in patients with T cell lymphocytosis and cytopenia.. Blood, 67(4), 914 - 918.
    • Tatham PE, O'Flynn K, Linch DC (1986). The relationship between mitogen-induced membrane potential changes and intracellular free calcium in human T-lymphocytes.. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 856(2), 202 - 211.
    • O'Flynn K, Russul-Saib M, Ando I, Wallace DL, Beverley PC, Boylston AW, Linch DC (1986). Different pathways of human T-cell activation revealed by PHA-P and PHA-M.. Immunology, 57(1), 55 - 60.

    1985

    • O'Flynn K, Krensky AM, Beverley PC, Burakoff SJ, Linch DC (1985). Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor.. Nature, 313(6004), 686 - 687.
    • Knott LJ, Levinsky RJ, Newland AC, Jones HM, Linch DC (1985). Bone marrow T cell colony-forming cells: studies of their origin and use in monitoring T cell-depleted bone marrow grafts.. Clinical and Experimental Immunology, 62(3), 561 - 569.
    • Miller BA, Lipton JM, Linch DC, Burakoff SJ, Nathan DG (1985). Thy-1 is a differentiation antigen that characterizes immature murine erythroid and myeloid hematopoietic progenitors.. Journal of Cellular Physiology, 123(1), 25 - 32.
    • Friedman AD, Linch DC, Miller B, Lipton JM, Javid J, Nathan DG (1985). Determination of the hemoglobin F program in human progenitor-derived erythroid cells.. Journal of Clinical Investigation, 75(4), 1359 - 1368.
    • Macintyre EA, Linch DC, Macey MG, Newland AC (1985). Successful response to intravenous immunoglobulin in autoimmune haemolytic anaemia.. British Journal of Haematology, 60(2), 387 - 388.
    • KNOTT LJ, LINCH DC, JONES HM, GOLDSTONE A, NEWLAND AC, LEVINSKY RJ (1985). ASSESSMENT OF T-CELL DEPLETION FROM BONE-MARROW GRAFTS. EXP HEMATOL, 13, 98 - 98.
    • O'Flynn K, Zanders ED, Lamb JR, Beverley PC, Wallace DL, Tatham PE, Tax WJ, Linch DC (1985). Investigation of early T cell activation: analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration.. European Journal of Immunology, 15(1), 7 - 11.
    • OFLYNN K, LINCH DC (1985). INVESTIGATION OF THE FUNCTIONAL-PROPERTIES OF CELL-SURFACE ANTIGENS IN NORMAL AND MALIGNANT T-CELLS. BRIT J HAEMATOL, 61(3), 549 - 549.
    • YARDUMIAN DA, OFLYNN K, LINCH DC, MACHIN SJ (1985). THE INTERACTION OF A PROSTACYCLIN ANALOG AND HEPARIN ON PLATELET-FUNCTION. BRIT J HAEMATOL, 61(3), 554 - 554.
    • MACINTYRE EA, NEWLAND AC, MACEY MG, LINCH DC (1985). THE USE OF INTRAVENOUS IMMUNOGLOBULIN (IGG) IN AUTOIMMUNE HEMOLYTIC-ANEMIA. BRIT J HAEMATOL, 61(3), 559 - 560.
    • GOLDSTONE AH, ANDERSON CC, CAWLEY JC, LINCH DC, JONES MJ, FRANKLIN JM, BOUGHTON BJ, RICHARDS JDM (1985). AN UPDATE OF PATIENTS WITH ACUTE-LEUKEMIA TREATED WITH INTENSIVE CHEMOTHERAPY AND A DOUBLE AUTOGRAFT PROTOCOL, PREVIOUSLY PRESENTED IN NOVEMBER 1983. BRIT J HAEMATOL, 61(3), 563 - 563.
    • ANDERSON CC, SOUHAMI RL, LINCH DC, CAWLEY JC, HARPER PJ, MACHIN SJ, JELIFFE AM, RICHARDS JDM, GOLDSTONE AH (1985). LOCAL EXPERIENCE IN TREATING ADVANCED LYMPHOMA WITH INTENSIVE CHEMOTHERAPY FOLLOWED BY AUTOLOGOUS BONE-MARROW RESCUE. BRIT J HAEMATOL, 61(3), 563 - 564.
    • YARDUMIAN DA, OFLYNN K, LINCH DC, MACHIN SJ (1985). THE ANTI-PLATELET ACTION OF PROSTACYCLIN ANALOG-ZK 36374 IS MODIFIED BY THE PRESENCE OF HEPARIN. THROMB HAEMOSTASIS, 54(1), 16 - 16.
    • PHILIP T, BIRON P, MARANINCHI D, GOLDSTONE AH, HERVE P, SOUILLET G, GASTAUT JL, PLOUVIER E, FLESH Y, PHILIP I, HAROUSSEAU JL, LEMEVEL A, REBATTU P, LINCH DC, FREYCON F, MILAN JJ, SOUHAMI RL (1985). MASSIVE CHEMOTHERAPY WITH AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN 50 CASES OF BAD PROGNOSIS NON-HODGKINS LYMPHOMA. BRIT J HAEMATOL, 60(4), 599 - 609.
    • GOLDSTONE AH, ANDERSON CC, SOUHAMI RL, LINCH DC, HARPER PG, MCLENNAN KA, JONES M, MACHIN SJ, JELLIFFE AM, CAWLEY JC, RICHARDS JDM (1985). VERY HIGH-DOSE CHEMOTHERAPY WITH ABMT IN ADULT PATIENTS WITH RESISTANT RELAPSED LYMPHOMA. INT J CELL CLONING, 3(4), 225 - 225.
    • LINCH DC (1985). ACTIVATED SUPPRESSOR T-CELLS AND THE ROLE OF INTERFERON IN APLASTIC-ANEMIA. IMMUNOL TODAY, 6(5), 155 - 156.
    • LINCH DC, JONES HM, HEUHNS ER, GOFF D, KAY LA, MACLENNAN K, BERLINER N (1985). HODGKIN CELL LEUKEMIA - PROOF OF B-CELL ORIGIN. BRIT J HAEMATOL, 60(2), 367 - 367.
    • NEWLAND AC, LINCH DC (1985). CHRONIC HELPER T-CELL LYMPHOPROLIFERATIVE DISEASE. BRIT J HAEMATOL, 60(2), 383 - 384.
    • LINCH DC, JONES HM, BERLINER N, MACLENNAN K, OFLYNN K, HUEHNS ER, KAY LA, GOFF K (1985). HODGKIN-CELL LEUKEMIA OF B-CELL ORIGIN - REPLY. LANCET, 1(8424), 340 - 340.
    • Linch DC, Jones HM, Berliner N, MacLennan K, O'Flynn K, Huehns ER, Kay LA, Goff K (1985). Hodgkin-cell leukaemia of B-cell origin.. The Lancet, 1(8420), 78 - 80.
    • Ross EJ, Linch DC (1985). The clinical response to treatment in adult Cushing's syndrome following remission of hypercortisolaemia.. Postgraduate Medical Journal, 61(713), 205 - 211.
    • Murphy MF, Metcalfe P, Waters AH, Linch DC, Cheingsong-Popov R, Carne C, Weller IV (1985). Immune neutropenia in homosexual men.. The Lancet, 1(8422), 217 - 218.
    • Letvin NL, Linch DC, Beardsley GP, McIntyre KW, Miller BA, Nathan DG (1985). Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis.. Journal of Clinical Investigation, 75(6), 1999 - 2005.
    • Linch DC, Donahue RE (1985). Production of human active BPA from TCGF independent T cell lines that do not excrete HTLV: proof of direct action of MLA-144 derived BPA using purified BFU-E.. British Journal of Haematology, 61(1), 71 - 82.
    • Linch DC, Lipton JM, Nathan DG (1985). Identification of three accessory cell populations in human bone marrow with erythroid burst-promoting properties.. Journal of Clinical Investigation, 75(4), 1278 - 1284.

    1984

    • Linch DC, Allen C, Beverley PC, Bynoe AG, Scott CS, Hogg N (1984). Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML.. Blood, 63(3), 566 - 573.
    • Linch DC, Newland AC, Turnbull AL, Knott LJ, MacWhannel A, Beverley P (1984). Unusual T cell proliferations and neutropenia in rheumatoid arthritis: comparison with classical Felty's syndrome.. Scandinavian Journal of Haematology, 33(4), 342 - 350.
    • O'Flynn K, Linch DC, Tatham PE (1984). The effect of mitogenic lectins and monoclonal antibodies on intracellular free calcium concentration in human T-lymphocytes.. Biochemical Journal, 219(2), 661 - 666.
    • Linch DC, Levinsky RJ, Rodeck CH, Maclennan KA, Simmonds HA (1984). Prenatal diagnosis of three cases of severe combined immunodeficiency: severe T cell deficiency during the first half of gestation in fetuses with adenosine deaminase deficiency.. Clinical and Experimental Immunology, 56(2), 223 - 232.
    • Linch DC, Nadler LM, Luther EA, Lipton JM (1984). Discordant expression of human Ia-like antigens on hematopoietic progenitor cells.. The Journal of Immunology, 132(5), 2324 - 2329.
    • Linch DC, Goldstone AH (1984). Autologous bone marrow transplantation.. British Journal of Haematology, 58(1), 1 - 7.
    • Jones HM, Linch DC, Marcus RE, Singer CR, Goldstone AH (1984). Red cell removal from donor bone marrow.. British Journal of Haematology, 58(3), 553 - 554.
    • Linch DC, Nathan DG (1984). T cell and monocyte-derived burst-promoting activity directly act on erythroid progenitor cells.. Nature, 312(5996), 775 - 777.
    • Lipton JM, Linch DC (1984). The syndrome of T lymphocytosis: a model for the genetic restriction of hematopoietic suppression.. Progress in Clinical and Biological Research, 148, 197 - 210.
    • ANDERSON CC, LINCH DC, JONES M, CLOSS SP, CAWLEY JC, RICHARDS JDN, GOLDSTONE AH (1984). AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR PATIENTS WITH ACUTE-LEUKEMIA WHO ARE NOT CANDIDATES FOR ALLOGENEIC TRANSPLANTATION. BRIT J HAEMATOL, 58(1), 196 - 197.
    • LINCH DC, LIPTON JM, NATHAN DG (1984). DELINEATION OF CELLULAR INTERACTIONS IN ERYTHROPOIESIS USING HIGHLY PURIFIED ACCESSORY CELL AND PROGENITOR-CELL POPULATIONS. BRIT J HAEMATOL, 56(4), 671 - 672.
    • LINCH DC, FRIEDMAN A, LETVIN N, BEARDSLEY P, NATHAN DG (1984). THE HB-F PROGRAM IN PRIMATE ERYTHROID PROGENITOR CELLS AND THE EFFECTS OF HYDROXYUREA ON HB-F PRODUCTION. BRIT J HAEMATOL, 56(4), 672 - 672.
    • ANDERSON CC, LINCH DC, JONES M, CLOSS SP, CAWLEY JC, RICHARDS JDM, GOLDSTONE AH (1984). AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR PATIENTS WITH ACUTE-LEUKEMIA WHO ARE NOT CANDIDATES FOR ALLOGENEIC TRANSPLANTATION. BRIT J HAEMATOL, 56(4), 673 - 673.
    • LINCH DC (1984). INHIBITORY T-CELLS IN HEMATOPOIETIC FAILURE. IMMUNOL TODAY, 5(1), 14 - 15.
    • THOMAS RM, LINCH DC, HUEHNS ER (1984). CHANGE IN ERYTHROPOIETIN SENSITIVITY OF FETAL HEMATOPOIETIC PROGENITOR CELLS IN THE 3RD TRIMESTER. PEDIATR RES, 18(1), 96 - 96.
    • Letvin NL, Linch DC, Beardsley GP, McIntyre KW, Nathan DG (1984). Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea.. New England Journal of Medicine, 310(14), 869 - 873.
    • Scott CS, Linch DC, Bynoe AG, Allen C, Hogg N, Ainley MJ, Hough D, Roberts BE (1984). Electrophoretic and cytochemical characterization of alpha-naphthyl acetate esterases in acute myeloid leukemia: relationships with membrane receptor and monocyte-specific antigen expression.. Blood, 63(3), 579 - 587.

    1983

    • Thomas RM, Linch DC (1983). Identification of lymphocyte subsets in the newborn using a variety of monoclonal antibodies.. Archives of Disease in Childhood, 58(1), 34 - 38.
    • Linch DC, Levinsky RJ (1983). Prenatal diagnosis of immunodeficiency disorders.. British Medical Bulletin, 39(4), 399 - 404.
    • ARMITAGE RJ, LINCH DC, WORMAN CP, CAWLEY JC (1983). CYTO-CHEMISTRY OF HUMAN-LYMPHOCYTE SUBPOPULATIONS DELINEATED BY MONOCLONAL-ANTIBODIES. BRIT J HAEMATOL, 53(2), 352 - 353.
    • LEVINSKY RJ, LINCH DC, MCLELLAN K, RODECK CH, SIMMONDS HA (1983). ANTENATAL DIAGNOSIS OF SEVERE COMBINED IMMUNODEFICIENCY (SCID). ARCH DIS CHILD, 58(8), 649 - 649.
    • THOMAS RM, CANNING CE, COTES PM, LINCH DC, RODECK CH, ROSSITER CE, HUEHNS ER (1983). ERYTHROPOIETIN IN THE REGULATION OF HUMAN-FETAL ERYTHROPOIESIS. BRIT J HAEMATOL, 55(1), 186 - 186.
    • Scott CS, Bynoe AG, Linch DC, Allen C, Hough D, Roberts BE (1983). Membrane Fc-IgG and C3b receptors on myeloid leukaemia cells: a comparison with cytoplasmic acid naphthyl acetate esterase cytochemistry.. Journal of Clinical Pathology, 36(5), 555 - 558.
    • Davies EG, Levinsky RJ, Butler M, Thomas RM, Linch DC (1983). Lymphocyte subpopulations in primary immunodeficiency disorders.. Archives of Disease in Childhood, 58(5), 346 - 351.
    • Thomas RM, Canning CE, Cotes PM, Linch DC, Rodeck CH, Rossiter CE, Huehns ER (1983). Erythropoietin and cord blood haemoglobin in the regulation of human fetal erythropoiesis.. British Journal of Obstetrics and Gynaecology, 90(9), 795 - 800.
    • LEVINSKY RJ, DAVIES EG, BUTLER M, LINCH DC, GOLDSTONE AH (1983). PROBLEMS OF MISMATCHED BONE-MARROW TRANSPLANTATION FOR SEVERE COMBINED IMMUNODEFICIENCY USING SOY BEAN LECTIN FRACTIONATION. EXP HEMATOL, 11, 89 - 90.
    • GOLDSTONE AH, HARPER PG, LINCH DC, SOUHAMI RL, ANDERSON CC, MOSS FM, MARTIN PJ, RICHARDS JDM (1983). PATTERNS OF HEMATOLOGICAL RECOVERY IN AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR SMALL CELL-CARCINOMA OF BRONCHUS, CARCINOMA OF THE OVARY, AND ACUTE-LEUKEMIA AND LYMPHOMA. EXP HEMATOL, 11, 164 - 167.
    • Simmonds HA, Fairbanks LD, Webster DR, Rodeck CH, Linch DC, Levinsky RJ (1983). Rapid prenatal diagnosis of adenosine deaminase deficiency and other purine disorders using foetal blood.. Bioscience Reports, 3(1), 31 - 38.
    • Linch DC, Rodeck CH, Simmonds HA, Levinsky RJ (1983). Prenatal diagnosis for severe combined immunodeficiency.. Birth Defects Orig Artic Ser, 19(3), 121 - 123.
    • Linch DC, Beverley PC, Newland A, Turnbull A (1983). Treatment of a low grade T cell proliferation with monoclonal antibody.. Clinical and Experimental Immunology, 51(1), 133 - 140.
    • Levinsky RJ, Davies EG, Butler M, Abai A, Linch DC, Goldstone AH (1983). Problems of mismatched bone marrow transplantation for severe combined immunodeficiency after soybean lectin fractionation.. Birth Defects Orig Artic Ser, 19(3), 147 - 150.
    • Linch DC, Knott LJ, Thomas RM, Harper P, Goldstone AH, Davis EG, Levinski RJ (1983). T cell regeneration after allogeneic and autologous bone marrow transplantation.. British Journal of Haematology, 53(3), 451 - 458.
    • THOMAS RM, CANNING CE, COTES PM, LINCH DC, RODECK CH, ROSSITER CE, HUEHNS ER (1983). ERYTHROPOIETIN IN THE REGULATION OF HUMAN-FETAL ERYTHROPOIESIS. BIOL NEONATE, 43(5-6), 299 - 300.

    1982

    • Linch DC, Stewart JW, West C (1982). Blood and bone marrow cultures in a case of thrombocytopenia with absent radii.. Clinical and Laboratory Haematology, 4(3), 313 - 317.
    • Levinsky RJ, Linch DC, Beverly CL, Rodeck C (1982). Prenatal exclusion of severe combined immunodeficiency.. Archives of Disease in Childhood, 57(12), 958 - 960.
    • Linch DC, Boyle D, Beverley PC (1982). T cell and monocyte requirements for erythropoiesis.. Acta Haematologica, 67(1), 34 - 38.
    • SOUHAMI RL, HARPER PG, LINCH DC, GOLDSTONE AH, RICHARDS JDM, TRASK C, TOBIAS JS, SPIRO SG, GEDDES DM (1982). SINGLE-AGENT HIGH-DOSE CYCLOPHOSPHAMIDE WITH AUTOLOGOUS BONE-MARROW TRANSFUSION (ABMT) AS INITIAL TREATMENT FOR SMALL-CELL CARCINOMA OF THE BRONCHUS (SCCB). THORAX, 37(10), 783 - 783.
    • ARMITAGE RJ, LINCH DC, WORMAN CP, CAWLEY JC (1982). THE CYTO-CHEMISTRY OF HELPER AND SUPPRESSOR CELLS DEFINED BY MONOCLONAL-ANTIBODIES AND FC-RECEPTORS. BRIT J HAEMATOL, 52(1), 146 - 146.
    • LINCH DC, BEVERLEY PCL, NEWLAND AC, TURNBULL AL (1982). TREATMENT OF A LOW-GRADE T-CELL PROLIFERATION WITH MONOCLONAL-ANTIBODY. BRIT J HAEMATOL, 51(2), 323 - 324.
    • MILLS KHG, WORMAN CP, LINCH DC, BEVERLEY PCL, GOLDSTONE AH, CAWLEY JC (1982). AN INCREASE OF OKT8+ SUPPRESSOR T-CELLS IN AMEGAKARYOCYTIC THROMBOCYTOPENIA - THE ROLE OF SUPPRESSOR CELLS IN THE REGULATION OF HEMATOPOIESIS. BRIT J HAEMATOL, 50(4), 683 - 683.
    • Linch DC, Knott LJ, Patterson KG, Cowan DA, Harper PG (1982). Bone marrow processing and cryopreservation.. Journal of Clinical Pathology, 35(2), 186 - 190.
    • Worman CP, Mills KH, Linch DC, Beverley PC, Goldstone AH, Cawley JC (1982). A megakaryocytic thrombocytopenia associated with the excess of Leu 2a+ suppressor cells.. Scand J Haematol, 28(3), 215 - 219.
    • Baines AJ, Banga JP, Gratzer WB, Linch DC, Huehns ER (1982). Red cell membrane protein anomalies in congenital dyserythropoietic anaemia, type II (HEMP AS).. British Journal of Haematology, 50(4), 563 - 574.
    • Linch DC, Knott LJ, Rodeck CH, Huehns ER (1982). Studies of circulating hemopoietic progenitor cells in human fetal blood.. Blood, 59(5), 976 - 979.
    • Linch DC, Beverley PC, Levinsky RJ, Rodeck CH (1982). Phenotypic analysis of fetal blood leucocytes: potential for prenatal diagnosis of immunodeficiency disorders.. Prenatal Diagnosis, 2(3), 211 - 218.
    • Linch DC, Walker H, Roberts P, McKinnon J, Goldstone AH, Huehns ER (1982). A chronic myeloproliferative disorder associated with monosomy 7 in the bone marrow cells; normal karyotype in acute transformation.. British Journal of Haematology, 51(3), 439 - 444.
    • Beverley PC, Linch DC, Callard RE, Worman CP, Cawley JC (1982). Cytopenia and T cell proliferation.. Journal of Clinical Immunology, 2(3), 135S - 141S.
    • Armitage RJ, Linch DC, Worman CP, Cawley JC (1982). The morphology and cytochemistry of human T-cell subpopulations defined by monoclonal antibodies and Fc receptors.. British Journal of Haematology, 51(4), 605 - 613.
    • Newland AC, Linch DC (1982). Immune guided missiles.. British Medical Journal (Clinical Research Ed.), 285(6343), 735 - 736.
    • Ross EJ, Linch DC (1982). Cushing's syndrome--killing disease: discriminatory value of signs and symptoms aiding early diagnosis.. The Lancet, 2(8299), 646 - 649.
    • Catovsky D, Linch DC, Beverley PC (1982). T cell disorders in haematological diseases.. Clinics in Haematology, 11(3), 661 - 695.
    • LINCH DC, KNOTT LJ, THOMAS R, HARPER P, GOLDSTONE AH, DAVIES EG, LEVINSKY RJ (1982). T-CELL REGENERATION AFTER ALLOGENEIC AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION. EXP HEMATOL, 10, 133 - 133.
    • Linch DC, Hutton R, Cowan D, Moore AR, Richards JD, Wilkinson LS (1982). Primary thrombocythaemia in childhood.. Scandinavian Journal of Haematology, 28(1), 72 - 76.

    1981

    • LINCH DC, WORMAN CP, CAWLEY JC, LYDDYARD PM, CALLARD RC, BEVERLEY PCL (1981). ABNORMAL T-CELL POPULATIONS IN PURE RED-CELL APLASIA AND SEVERE NEUTROPENIA. BRIT J HAEMATOL, 47(4), 627 - 627.
    • Linch DC, Cawley JC, Worman CP, Galvin MC, Roberts BE, Callard RE, Beverley PC (1981). Abnormalities of T-cell subsets in patients with neutropenia and an excess of lymphocytes in the bone marrow.. British Journal of Haematology, 48(1), 137 - 145.
    • HARPER PG, LINCH DC, GOLDSTONE AH, RICHARDS JDM, SOUHAMI RL (1981). HEMATOLOGICAL EFFECTS OF HIGH-DOSE CYCLOPHOSPHAMIDE AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION. BRIT J HAEMATOL, 49(1), 138 - 139.
    • Linch DC, Beverley PC, Newland AC, Turnbull AL (1981). Treatment of T cell proliferation with monoclonal antibody.. The Lancet, 2(8245), 524 - .
    • Linch DC, Cawley JC, MacDonald SM, Masters G, Roberts BE, Antonis AH, Waters AK, Sieff C, Lydyard PM (1981). Acquired pure red-cell aplasia associated with an increase of T cells bearing receptors for the Fc of IgG.. Acta Haematologica, 65(4), 270 - 274.
    • Patterson KG, Linch DC, Rosendaal M (1981). In situ cytoenzymatic identification of human bone marrow colonies grown in agar: a simple method with automated cytochemistry reagents.. Journal of Clinical Pathology, 34(8), 935 - 938.

    1980

    • LINCH DC, BEVERLEY PCL, DELIA D (1980). ISOLATION OF HUMAN-BONE MARROW STEM-CELLS USING MONOCLONAL-ANTIBODIES AND FLUORESCENCE ACTIVATED CELL SORTING. BRIT J HAEMATOL, 46(2), 324 - 325.
    • Linch DC, Watson LC, Cowie AG (1980). Ectopic parathyroid adenomas.. Journal of the Royal Society of Medicine, 73(9), 638 - 640.
    • Linch DC, Gillmer DJ, Whimster WF, Keates JR (1980). Rheumatoid aortic valve prolapse requiring emergency aortic valve replacement.. British Heart Journal, 43(2), 237 - 240.
    • LINCH DC, BEVERELEY PCL, DELIA D (1980). SEPARATION OF HUMAN COLONY-FORMING CELLS FROM LYMPHOCYTES USING A MONOCLONAL ANTI-LEUCOCYTE ANTIBODY. BRIT J HAEMATOL, 45(1), 169 - 170.

    1979

    • GEDDES DM, LINCH DC, SKEATES SJ, DAGGETT PR (1979). WEIGHT-LOSS AND THYROID-FUNCTION IN EMPHYSEMA. THORAX, 34(5), 706 - 706.
    • Linch DC, Ross EJ (1979). Thyrotrophin-releasing-hormone test in phaeochromocytoma.. The Lancet, 1(8109), 210 - .
    • Banga JP, Pinder JC, Gratzer WB, Linch DC, Huehns ER (1979). An erythrocyte membrane-protein anomaly in march haemoglobinuria.. The Lancet, 2(8151), 1048 - 1049.
    • Franklin IM, Linch DC (1979). Dexamethasone and in-vitro sickling.. The Lancet, 2(8143), 645 - 646.
    • Linch DC, Acton CH (1979). Ehlers-Danlos syndrome presenting with juvenile destructive periodontitis.. British Dental Journal, 147(4), 95 - 96.

    1978

    • Linch DC, Shaw KM, Muhlemann MF, Ross EJ (1978). Bromocriptine-induced postural hypotension in acromegaly.. The Lancet, 2(8084), 320 - 321.
    • Linch DC (1978). Neutropenia, splenomegaly and high titre antinuclear antibody.. Journal of the Royal Society of Medicine, 71(2), 143 - 144.