Mr David Choi


Personal Profile

Name: David Choi Email:
Title: Mr Tel: 0845 155 5000
Department: Brain Repair & Rehabilitation Fax:
Position: Reader in Neurosurgery Address: Institute of Neurology, Queen Square, London, WC1N 3BG
Research Domain: Neuroscience, Personalised Medicine, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page:  


Research Description

Research projects include:

- Laboratory models for spinal cord and spinal root injury and repair.

- Regenerative medicine, olfactory ensheathing cells.

- GMP production of human cells for nerve repair.

- Spine tumours

- Craniocervical junction and skull base surgery.

Research Activities

Education Description

UCL Collaborators

External Collaborators



    • Choi D, Gladwin K (2015). Olfactory ensheathing cells: Part II--source of cells and application to patients.. World Neurosurg, 83(2), 251 - 256. doi:10.1016/j.wneu.2013.07.016
    • Choi D (2015). Expert's comment concerning Grand Rounds case entitled: "trans-oral approach for the management of a C2 neuroblastoma" (K. M. I. Salem, J. Visser, and N. A. Quraishi).. Eur Spine J, 24(1), 177 - 179. doi:10.1007/s00586-014-3662-7
    • Choi D (2015). Fractures in ankylosing disorders of the spine; easy to miss and high risk of deterioration.. World neurosurgery, , - . doi:10.1016/j.wneu.2015.01.046
    • Gladwin K, Choi D (2015). Olfactory ensheathing cells: Part i - Current concepts and experimental laboratory models. World Neurosurgery, 83(1), 114 - 119. doi:10.1016/j.wneu.2013.03.010


    • Wang M, B√ľnger CE, Li H, Sun M, Helmig P, Borhani-Khomani G, Hansen ES, Hoey K, Wu CS, Choi D (2014). Improved patient selection by stratified surgical intervention: Aarhus Spinal Metastases Algorithm. Spine Journal, , - . doi:10.1016/j.spinee.2015.03.012
    • Choi D (2014). Interspinous distraction reply. BRITISH JOURNAL OF NEUROSURGERY, 28(6), 821 - 821.
    • Choi D (2014). Failed foramen magnum decompression for Chiari malformation: the challenge of postoperative brainstem shift and cerebellar ptosis.. World Neurosurg, 81(5-6), 702 - 705. doi:10.1016/j.wneu.2013.03.028
    • Chen CR, Kachramanoglou C, Li D, Choi D, Andrews P (2014). Anatomy and Cellular Constituents of the Human Olfactory Mucosa: A Review. Journal of Neurological Surgery, Part B: Skull Base, , - . doi:10.1055/s-0033-1361837
    • Choi D, Subramanian A, Elwell V, Andrews P, Roberts D, Gleeson M (2014). Endoscopic Transnasal Surgery as a Replacement for Maxillotomy Techniques to Approach the Central Skull Base: Fewer Complications and More Acceptable to Patients?. JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 75(3), 165 - 170. doi:10.1055/s-0033-1358375
    • Esposito M, Erro R, Edwards MJ, Bhatia KP, Cawley N, Choi D, Cordivari C (2014). The pathophysiology of symptomatic propriospinal myoclonus. Movement Disorders, , - . doi:10.1002/mds.25951


    • Kachramanoglou C, De Vita E, Thomas DL, Wheeler-Kingshott CAM, Balteau E, Carlstedt T, Choi D, Thompson AJ, Ciccarelli O (2013). Metabolic Changes in the Spinal Cord After Brachial Plexus Root Re-implantation. NEUROREHABILITATION AND NEURAL REPAIR, 27(2), 118 - 124. doi:10.1177/1545968312457825
    • Kachramanoglou C, Law S, Andrews P, Li D, Choi D (2013). Culture of olfactory ensheathing cells for central nerve repair: the limitations and potential of endoscopic olfactory mucosal biopsy.. Neurosurgery, 72(2), 170 - 178. doi:10.1227/NEU.0b013e31827b99be
    • Kachramanoglou C, De Vita E, Thomas DL, Wheeler-Kingshott CA, Balteau E, Carlstedt T, Choi D, Thompson AJ, Ciccarelli O (2013). Metabolic changes in the spinal cord after brachial plexus root re-implantation.. Neurorehabil Neural Repair, 27(2), 118 - 124. doi:10.1177/1545968312457825
    • Kirkman MA, Borg A, Al-Mousa A, Haliasos N, Choi D (2013). Quality-of-Life after Anterior Skull Base Surgery: A Systematic Review. Journal of Neurological Surgery, Part B: Skull Base, , - . doi:10.1055/s-0033-1359303
    • Choi D, Crockard HA (2013). Evolution of transoral surgery: three decades of change in patients, pathologies, and indications.. Neurosurgery, 73(2), 296 - 303. doi:10.1227/01.neu.0000430324.24623.10
    • Choi D, Morris S, Crockard A, Albert T, Bunger C, Fehlings M, Harrop J, Kawahara N, Martin JA, Massicotte EM, Mazel C, Oner FC, Peul W, Tomita K, Wang M (2013). Assessment of quality of life after surgery for spinal metastases: position statement of the Global Spine Tumour Study Group.. World Neurosurg, 80(6), e175 - e179. doi:10.1016/j.wneu.2013.02.054
    • Choi D, Crockard A, Morris S, Albert T, Harrop J, Bunger C, Fehlings M, Massicotte EM, Kawahara N, Tomita K, Martin JA, Mazel C, Oner FC, Peul W, Wang M (2013). Assessment of quality of life after surgery for spinal metastases: Position statement of the global spine tumour study group. World Neurosurgery, 80(6), - . doi:10.1016/j.wneu.2013.02.054


    • Kachramanoglou C, Farmer SF, Choi D (2012). Sequestered disc fragment mimicking a psoas abscess. Spine Journal, , - .
    • Choi D, Timothy J, Richards O (2012). Response to: Cervical arthroplasty: the beginning, the middle, the end?. BRITISH JOURNAL OF NEUROSURGERY, 26(4), 584 - 584. doi:10.3109/02688697.2012.704099
    • Borg A, Nurboja B, Timothy J, Choi D (2012). Interspinous distractor devices for the management of lumbar spinal stenosis: a miracle cure for a common problem?. Br J Neurosurg, 26(4), 445 - 449. doi:10.3109/02688697.2012.680630
    • Nurboja B, Kachramanoglou C, Choi D (2012). Cervical laminectomy vs laminoplasty: is there a difference in outcome and postoperative pain?. Neurosurgery, 70(4), 965 - 970. doi:10.1227/NEU.0b013e31823cf16b
    • Richards O, Choi D, Timothy J (2012). Cervical arthroplasty: the beginning, the middle, the end?. BRITISH JOURNAL OF NEUROSURGERY, 26(1), 2 - 6. doi:10.3109/02688697.2011.595846
    • Vergara P, Bal JS, Hickman Casey AT, Crockard HA, Choi D (2012). C1-C2 posterior fixation: are 4 screws better than 2?. Neurosurgery, 71(1 Suppl Operative), 86 - 95. doi:10.1227/NEU.0b013e318243180a
    • Nurboja B, Chaudhuri A, David KM, Casey AT, Choi D (2012). Swelling and enhancement of the cervical spinal cord: when is a tumour not a tumour?. Br J Neurosurg, 26(4), 450 - 455. doi:10.3109/02688697.2011.633636
    • Choi D, Petrik V, Fox S, Parkinson J, Timothy J, Gullan R (2012). Motion preservation and clinical outcome of porous coated motion cervical disk arthroplasty.. Neurosurgery, 71(1), 30 - 37. doi:10.1227/NEU.0b013e31824e512e


    • Kachramanoglou C, Li D, Andrews P, East C, Carlstedt T, Raisman G, Choi D (2011). Novel strategies in brachial plexus repair after traumatic avulsion.. Br J Neurosurg, 25(1), 16 - 27. doi:10.3109/02688697.2010.522744
    • Kachramanoglou C, Carlstedt T, Koltzenburg M, Choi D (2011). Self-mutilation in patients after nerve injury may not be due to deafferentation pain: a case report.. Pain Med, 12(11), 1644 - 1648. doi:10.1111/j.1526-4637.2011.01242.x
    • Chen CW, Kachramanoglou C, Revesz T, Choi D (2011). Rosai-Dorfman disease presenting as a thoracic intradural extramedullary spinal tumor but without extraspinal manifestations. Acta Neurochir.(Wien.), , - . doi:10.1007/s00701-011-1176-1
    • Raisman G, Carlstedt T, Choi D, Li Y (2011). Clinical prospects for transplantation of OECs in the repair of brachial and lumbosacral plexus injuries: opening a door.. Exp Neurol, 229(1), 168 - 173. doi:10.1016/j.expneurol.2010.05.007


    • Choi D, Gleeson M (2010). Surgery for chordomas of the craniocervical junction: lessons learned. Skull.Base., 20(1), 41 - 45. doi:10.1055/s-0029-1242984
    • Choi D, Melcher R, Harms J, Crockard A (2010). Outcome of 132 operations in 97 patients with chordomas of the craniocervical junction and upper cervical spine. Neurosurgery, 66(1), 59 - 65. doi:10.1227/01.NEU.0000362000.35742.3D
    • Choi D, Crockard A, Bunger C, Harms J, Kawahara N, Mazel C, Melcher R, Tomita K (2010). Review of metastatic spine tumour classification and indications for surgery: the consensus statement of the Global Spine Tumour Study Group. Eur.Spine J, 19(2), 215 - 222. doi:10.1007/s00586-009-1252-x


    • Nurboja B, Choi D (2009). Extensive spinal cord oedema and early syrinx formation due to tension pseudomeningocele after foramen magnum decompression. British Journal of Neurosurgery, 23(4), 443 - 445. doi:10.1080/02688690802716137
    • Hill CS, Khan AF, Bloom S, McCartney S, Choi D (2009). A rare case of vomiting: fourth ventricular B-cell lymphoma. Journal of Neuro-Oncology, 93(2), 261 - 262. doi:10.1007/s11060-008-9765-4
    • Stacpoole S, McGuigan C, Phadke SL, Stevens J, Choi D, Kapoor R (2009). Spinal claudication due to myxopapillary ependymoma.. BMJ Case Rep, 2009, - . doi:10.1136/bcr.09.2008.0969
    • Quinn J, Rabin N, Rodriguez-Justo M, Choi D, Yong K (2009). Multiple myeloma presenting with spinal cord compression during pregnancy. Annals of Hematology, 88(2), 181 - 182. doi:10.1007/s00277-008-0558-9
    • Singh A, Choi D, Crockard A (2009). Use of walking data in assessing operative results for cervical spondylotic myelopathy: long-term follow-up and comparison with controls. Spine, 34(12), 1296 - 1300. doi:10.1097/BRS.0b013e3181a09796
    • Choi D, Crockard HA (2009). How and why should we benchmark clinical outcomes and quality of life for surgery in spinal metastases?. British Journal of Neurosurgery, 23(1), 3 - 4. doi:10.1080/02688690802546872
    • Farmer S, Casey A, Choi D, Howard R, Raisman G (2009). Spinal cord disorders. In Clarke C, Howard R, Rossor M, Shorvon S (Ed.), Neurology: a Queen Square textbook (pp. 585 - 628). : Wiley-Blackwell.


    • Choi D, Li D, Law S, Powell M, Raisman G (2008). A prospective observational study of the yield of olfactory ensheathing cells cultured from biopsies of septal nasal mucosa. Neurosurgery, 62(5), 1140 - 1145.
    • Seo M, Choi D (2008). Adjacent segment disease after fusion for cervical spondylosis; myth or reality?. British Journal of Neurosurgery, 22(2), 195 - 199. doi:10.1080/02688690701790605
    • Jayakumar P, Choi D, Casey A (2008). Late presentation of a type III axis fracture with spondyloptosis. Annals of the Royal College of Surgeons of England, 90(3), W1 - W3. doi:10.1308/147870808X257238
    • Knafo S, Choi D (2008). Clinical studies in spinal cord injury: moving towards successful trials. British Journal of Neurosurgery, 22(1), 3 - 12. doi:10.1080/02688690701593595
    • Choi D, Crockard HA (2008). Perisellar tumours including chordoma, optic nerve glioma, meningioma, hemangiopericytoma, and glomus tumors. In Hay ID, Wass JAH (Ed.), Clinical Endocrine Oncology (pp. 302 - 309). : Blackwell Publishing.
    • Choi D, Law S, Raisman G, Li D (2008). Olfactory ensheathing cells in the nasal mucosa of the rat and human. British Journal of Neurosurgery, 22(2), 301 - 302. doi:10.1080/02688690701883442


    • Li Y, Yamamoto M, Raisman G, Choi D, Carlstedt T (2007). An experimental model of ventral root repair showing the beneficial effect of transplanting olfactory ensheathing cells. Neurosurgery, 60(4), 734 - 741.
    • Stacpoole SR, McGuigan C, Lewis SJ, Phadke R, Stevens J, Choi D, Kapoor R (2007). Spinal claudication due to myxopapillary ependymoma. Practical Neurology, 7(6), 394 - 396. doi:10.1136/jnnp.2007.134049
    • Choi D, Crockard A (2007). Transoral surgery. In Baron E , Vaccaro A (Ed.), Operative techniques: Spine Surgery (pp. - ). : Elsevier.


    • Choi D, Casey ATH, Crockard HA (2006). Neck problems in rheumatoid arthritis-changing disease patterns, surgical treatments and patients' expectations. RHEUMATOLOGY, 45(10), 1183 - 1184. doi:10.1093/rheumatology/kel251
    • Choi D, Jayakumar P, Casey A (2006). The patient always knows best! Conservative management of a large central disc prolapse. BRIT J NEUROSURG, 20(1), 63 - 63. doi:10.1080/02688690600598349
    • Choi D, Crockard A (2006). Transoral Odontoidectomy. In Fessler RG , Sekhar L (Ed.), Atlas of Neurosurgical techniques: Spine and Peripheral Nerves (pp. - ). : Thieme.
    • Choi D, Crockard A (2006). Transoral approaches to the craniocervical junction.. In Fessler RG , Sekhar L (Ed.), Atlas of Neurosurgical techniques: Spine and Peripheral Nerves (pp. - ). : Thieme.
    • Choi D, Crockard A (2006). Transoral closure. In Fessler RG , Sekhar L (Ed.), Atlas of Neurosurgical techniques: Spine and Peripheral Nerves . (pp. - ). : Thieme.
    • Choi D, Crockard A (2006). Extended transoral procedures and midline intradural tumor resection. In Fessler RG , Sekhar L (Ed.), Atlas of Neurosurgical techniques: Spine and Peripheral Nerves . (pp. - ). : Thieme.


    • Choi D, Raisman G (2005). Disorganization of the facial nucleus after nerve lesioning and regeneration in the rat: effects of transplanting candidate reparative cells to the site of injury.. Neurosurgery, 56(5), 1093 - 1100.


    • Choi D, Raisman G (2004). After facial nerve damage, regenerating axons become aberrant throughout the length of the nerve and not only at the site of the lesion: an experimental study. Br J Neurosurg, 18(1), 45 - 48.
    • Shah A, Choi D (2004). Subfalcine herniation in the absence of a high pressure collection or mass: 'brain-slump'?. BRIT J NEUROSURG, 18(3), 273 - 274. doi:10.1080/02688690410001732724


    • Rodriquez-Neidenfuhr M , Vazquez T , Choi D , Parkin I , Sanudo J (2003). Supernumerary humeral heads of the biceps brachii muscle revisited.. Clinical Anatomy, 16(3), 197 - 203.
    • Choi D, Raisman G (2003). Immune rejection of a facial nerve xenograft does not prevent regeneration and the return of function: an experimental study. Neuroscience, 121(2), 501 - 507.


    • Choi D, Li D, Raisman G (2002). Fluorescent retrograde neuronal tracers that label the rat facial nucleus: a comparison of Fast Blue, Fluoro-ruby, Fluoro-emerald, Fluoro-Gold and DiI. J Neurosci.Methods, 117(2), 167 - 172.
    • Bonastre V , Rodriquez-Neidenfuhr M , Choi D , Sanudo J (2002). The coexistence of a pectoralis quartus and an unusual axillary arch: case report and review.. Clinical Anatomy, 15(5), 366 - 370.
    • Choi D, Rodriguez-Niedenfuhr M, Vazquez T, Parkin I, Sanudo JR (2002). Patterns of connections between the musculocutaneous and median nerves in the axilla and arm. Clin.Anat., 15(1), 11 - 17. doi:10.1002/ca.1085
    • Choi D, Raisman G (2002). Somatotopic organization of the facial nucleus is disrupted after lesioning and regeneration of the facial nerve: the histological representation of synkinesis. Neurosurgery, 50(2), 355 - 362.


    • Choi D, Dunn LT (2001). Facial nerve repair and regeneration: an overview of basic principles for neurosurgeons. Acta Neurochir.(Wien.), 143(2), 107 - 114.


    • Choi D, Seex K (2000). Intracranial meningioma following childhood irradiation for leukaemia. Br.J.Haematol., 108(4), 665 - .
    • Choi D, Taylor WA (2000). The incidence of neurosurgical disease in patients who are referred to a neurosurgical centre for CT scanning: should district general hospital scanners be more active?. Scott.Med.J., 45(4), 113 - 114.
    • Choi D (2000). Cervical x-rays and the atlanto-axial region: supplementary computed tomography may be required in trauma. Scott.Med.J., 45(5), 151 - .


    • Choi D, Schulz U, Seex K (1998). Gliomatosis cerebri: a brain tumour which is too difficult to treat?. Scott.Med.J., 43(3), 84 - 86.
    • Choi D , Carter R (1998). Endoscopic sigmoidopexy: a safer way to treat sigmoid volvulus in the elderly.. Journal of the Royal College of Surgeons Edinburgh, 19(43), 64 - .
    • Bhuller A , Sanudo J , Abrahams P , Choi (1998). Intracranial course and relations of the hypoglossal nerve. An anatomic study.. Surgical Radiologic Anatomy, 20, 109 - 112.


    • Choi , Abrahams P (1997). An atlas vertebra with a centrum? a case report of an abnormal atlas and axis.. Surgical Radiologic Anatomy, 19, 269 - 271.


    • Choi D, Spann R (1996). Traumatic cerebrospinal fluid leakage: risk factors and the use of prophylactic antibiotics. Br J Neurosurg, 10(6), 571 - 575.
    • Choi D, Carroll N , Abrahams P (1996). Spinal cord diameters in cadaveric specimens and magnetic resonance scans: assessing embalming artefacts.. Surgical Radiologic Anatomy, 18, 133 - 135.

    • Choi D (). Failed foramen magnum decompression for chiari malformation: The challenge of postoperative brainstem shift and cerebellar ptosis. World Neurosurgery, 81(5-6), 702 - 705. doi:10.1016/j.wneu.2013.03.028