Prof Christine Kinnon

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Personal Profile

Name: Christine Kinnon Email: c.kinnon@ucl.ac.uk
Title: Prof Tel: 020 7905 2880
Department: ICH Infect, Imm, Infla. & Physio Med Fax:
Position: Professor of Molecular Immunology Address: UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH
Research Domain: Experimental Medicine, Infection, Immunology & Inflammation, Personalised Medicine, Populations & Lifelong Health, Reproduction & Development Web Page:  

Profile

Research Description

My research has involved the elucidation of the molecular and cellular defects in inherited immunodeficiency disorders which has resulted in our identification of several disease causing genes. We are now investigating the functions of the protein products of these genes, in both health and disease. We are translating the results of this basic research into new and improved strategies for treatment, principally by the development of techniques for the cure of these disorders by somatic gene therapy techniques.

We have initiated phase I clinical trials for the treatment of X-linked severe combined immunodeficiency (SCID), adenosine deaminase (ADA) deficient SCID, X-linked chronic granulomatous disease (CGD) and Wiskott-Aldrich syndrome using gene therapy techniques. 


Research Activities

Haematopoietic Stem Cell Biology

Molecular basis of primary immunodeficiency: gene therapy for primary immunodeficiency

Education Description

Student Supervision: I have supervised research students at BSc, MSc, MPhil and PhD level, seeing 15 PhD students to completion as Primary supervisor.

 Lecturing: I have been responsible for teaching on a variety of under-graduate (UG) and post-graduate (PG) courses within and external to UCL throughout the year, including a number of European Summer Schools. I am currently teaching on the following courses: UCL INIM3005 Immunodeficiency and therapeutics; UCL CHLDGX05 Molecular and Genetic Basis of Paediatrics; UCL CHLDGG03 Molecular Aspects of Cell and Gene Therapy; KCL MIMM103 Immune Disorders and Infection; GKT 6BBYG305 Genes, Genetic Disease and Gene Therapy; University of Oxford MSc in Integrated Immunology.

 Management of Teaching: Since 2009 I have been Director of Teaching and Learning (Divisional Graduate Tutor – Taught Courses) at ICH. I am Vice Dean for Education in the new Faculty of Population Health Sciences (since 2011). I developed and run the new UCL MSc in Cell and Gene Therapy (since 2011).

 

UCL Collaborators

Dr Maria Alonso-Ferrero; Dr Steven Howe

External Collaborators

Publications

    2014

    • Abdul-Razak H, Rocca C, Howe S, Alonso-Ferrero ME, Gabriel R, Bartholomae C, Gan CHV, Garin M, Molina Estevez FJ, Roberts A, Blundell M, Wang J, Prakash V, Gueenechea G, Holmes M, Gregory P, Kinnon C, von Kalle C, Schmidt M, Antonio Bueren J, Thrasher A, Yanez-Munoz R (2014). Gene editing of mutated Prkdc gene in classical scid mouse.
    • Alonso-Ferrero ME, Bartolovic K, Kinnon C, Mata M, Waddington SN, Milsom MD, van Til NP, Howe SJ (2014). Transient Expression of Genes From Integrative Deficient Lentiviral Vectors Improves Blood Progenitor Cell Expansion, Survival and Engraftment.

    2013

    • Aitchison KL, Rahim AA, Reed M, Burke DG, Hughes DA, Heales S, Kinnon C, Waddington SN, Howe SJ (2013). Lentiviral vectors for gene therapy of type I Gaucher disease.
    • Alonso-Ferrero ME, Bartolovic K, Kinnon C, Mata M, Milsom MD, vanTil NP, Howe SJ (2013). Transient manipulation of haematopoietic stem cells with integrative deficient lentiviral vectors for improved cell expansion, survival and engraftment.
    • Aitchison K, Rahim A, Reed M, Hughes D, Kinnon C, Waddington S (2013). Developing lentiviral vectors for gene thrapy of type I Gaucher disease.
    • Alonso-Ferrero M, van Til N, Bartolovic K, Kinnon C, Mata M, Milsom M, Howe S (2013). Manipulation of haematopoietic stem cell biology using transient gene expression from integration-deficient lentiviral vectors.
    • Abdul-Razak HH, Rocca C, Howe SJ, Eugenia Alonso-Ferrero M, Gabriel R, Bartholomae CC, Gan CHV, Garin M, Javier Molina-Estevez F, Roberts AC, Blundell M, Gueenechea G, Holmes MC, Gregory PD, Kinnon C, von Kalle C, Schmidt M, Bueren JA, Thrasher AJ, Yanez-Munoz RJ (2013). Rescue of mouse Prkdc scid deficiency by transplantation of gene-repaired haematopoietic stem cells.
    • Rocca C, Abdul-Razak HH, Howe SJ, Alonso-Ferrero ME, Gabriel R, Bartholomae CC, Gan CHV, Garin M, Molina Estevez FJ, Roberts A, Blundell M, Wang J, Prakash V, Gueenechea G, Holmes MC, Gregory PD, Kinnon C, von Kalle C, Schmidt M, Antonio Bueren J, Thrasher AJ, Yanez-Munoz RJ (2013). Rescue of T-cell deficiency in PRKDC SCID mice by transplantation of gene-edited haematopoietic stem cells.

    2012

    • Pallant C, Cathomen T, Dannemann N, Qasim W, Naldini L, Kinnon C, Howe S, Thrasher A (2012). Targeting models of severe combined immunodeficiency for correction by zinc finger nucleases.
    • Aitchison KL, Rahim AA, Hughes D, Kinnon C, Waddington SN, Howe SJ (2012). Developing lentiviral vectors for gene therapy of Type I Gaucher Disease.
    • Vetrie D, Vořechovský I, Sideras P, Holland J, Davies A, Flinter F, Hammarström L, Kinnon C, Levinsky R, Bobrow M, Smith CI, Bentley DR (2012). The gene involved in X-linked agammaglobulinaemia is a member of the Src family of protein-tyrosine kinases. 1993.. J Immunol, 188(7), 2948 - 2955.
    • Abdul-Razak HH, Rocca C, Howe SJ, Estevez JFM, Gan CHV, Roberts A, Gregory PD, Holmes MC, Kinnon C, Thrasher AJ, Yanez-Munoz RJ (2012). Correction of mouse Prkdc scid deficiency by ZFN-driven gene targeting.
    • Pantoglou J, Abdul-Razak HH, Rocca C, Howe SJ, Gregory PD, Holmes MC, Kinnon C, Thrasher AJ, Yanez-Munoz RJ (2012). Specificity of a zinc-finger nuclease targeting mouse Prkdc: preparation of samples for analysis of off-target cutting.
    • Alonso-Ferrero ME, Bartolovic K, Kinnon C, Mata M, Van Til NP, Howe SJ (2012). Transient manipulation of haematopoietic stem cells with integrative deficient lentiviral vectors for improved cell expansion, survival and engraftment.

    2011

    • Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Zhang F, Bjorkegren E, Bayford J, Brown L, Davies EG, Kinnon C, Thrasher AJ, Adams S, Veys P, Fairbanks L, Bordon V, Petropolou T (2011). Immunodeficiency: Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Science Translational Medicine, 3(97), - . doi:10.1126/scitranslmed.3002716
    • Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Howe SJ, Bayford J, Brown L, Davies EG, Kinnon C, Thrasher AJ, Adams S, Al Ghonaium A (2011). Immunodeficiency: Long-term persistence of a polyclonal t cell repertoire after gene therapy for X-linked severe combined immunodeficiency. Science Translational Medicine, 3(97), - . doi:10.1126/scitranslmed.3002715
    • Santilli G, Kehl E, Parsley K, Cooray S, Buckland K, Blundell M, Bouma G, Galy A, Charrier S, Kinnon C, Thrasher AJ (2011). Development of a clinical trial of gene therapy for X-CGD using the pCCLCHIMGp91WPRE4 lentiviral vector. HUM GENE THER, 22(10), A52 - A52.
    • Aitchison KL, Rahim AA, Hughes DA, Kinnon C, Waddington SN, Howe SJ (2011). Lentiviral vectors for gene therapy of Type I Gaucher Disease. HUM GENE THER, 22(10), A44 - A44.
    • Cooray S, Gilmour KC, Parsley KL, Adams S, Howe SJ, Al Ghonaium A, Bayford J, Brown L, Davies EG, Kinnon C, Gasper HB, Thrasher AJ (2011). Persistence of a polyclonal T-cell repertoire in patients with SCID-X1 following gene therapy. HUM GENE THER, 22(10), A42 - A42.
    • Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, Bueren JA, Grez M, Thrasher AJ (2011). Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.. Mol Ther, 19(1), 122 - 132. doi:10.1038/mt.2010.226
    • Cooray S, Gilmour KC, Parsley KL, Zhang F, Bjorkegren E, Bayford J, Brown L, Davies EG, Veys P, Fairbanks L, Bordon V, Petropolou T, Kinnon C, Thrasher AJ, Gaspar HB (2011). Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. HUM GENE THER, 22(10), A40 - A40.
    • Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Zhang F, Adams S, Bjorkegren E, Bayford J, Brown L, Davies EG, Veys P, Fairbanks L, Bordon V, Petropoulou T, Kinnon C, Thrasher AJ (2011). Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction.. Sci Transl Med, 3(97), 97ra80 - . doi:10.1126/scitranslmed.3002716
    • Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Adams S, Howe SJ, Al Ghonaium A, Bayford J, Brown L, Davies EG, Kinnon C, Thrasher AJ (2011). Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency.. Sci Transl Med, 3(97), 97ra79 - . doi:10.1126/scitranslmed.3002715
    • Abeyewickreme A, Thrasher AJ, Kinnon C (2011). Bone morphogenetic protein-4 (BMP4) up regulates key haematopoietic genes in differentiating embryonic stem cells treated with BMP4 short hairpin RNA.. Br J Haematol, 155(5), 638 - 641. doi:10.1111/j.1365-2141.2011.08759.x
    • Ward NJ, Buckley SM, Waddington SN, Vandendriessche T, Chuah MK, Nathwani AC, McIntosh J, Tuddenham EG, Kinnon C, Thrasher AJ, McVey JH (2011). Codon optimization of human factor VIII cDNAs leads to high-level expression.. Blood, 117(3), 798 - 807. doi:10.1182/blood-2010-05-282707
    • Pallant C, Cathomen T, Dannemann N, Quasim W, Naldini L, Kinnon C, Howe S, Thrasher A (2011). Targeting models of severe combined immunodeficiency for correction by zinc finger nucleases. HUM GENE THER, 22(10), A41 - A41.

    2010

    • Samarasinghe S, Mancao C, Pule M, Nawroly N, Karlsson H, Brewin J, Openshaw P, Gaspar HB, Veys P, Amrolia PJ (2010). Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy. Blood, 115, 396 - 407.
    • Abdul-Razak HH, Rocca C, Howe SJ, Estevez FJM, Gan CHV, Roberts A, Broadstock M, Gregory PD, Holmes MC, Kinnon C, Thrasher AJ, Yanez-Munoz RJ (2010). Towards Correction of the scid Mouse by Gene Targeting.
    • Ward NJ, Buckley SM, Waddington SN, Nathwani AC, Tuddenham EG, Kinnon C, Thrasher AJ, McVey JH (2010). Correction of Murine Hemophilia A Using SIN Lentiviral Vectors Expressing Enhanced Human Factor VIII cDNAs.
    • Pallant C, Howe S, Qasim W, Kinnon C, Thrasher A (2010). Developing an In Vitro Model of Common Gamma Chain Deficiency for Correction by Zinc Finger Nucleases.
    • Santilli G, Brendel C, Almarza E, Beilin C, Blundell M, Haria S, Kinnon C, Bueren JA, Grez M, Thrasher AJ (2010). Targeted Lentiviral Gene Therapy to Rescue the X-CGD Phenotype.

    2009

    • Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike O, K C, S D, Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJ, Gale RE, Linch DC, Bayford J, Brown L, Quaye M, Kinnon C, Ancliff P, Webb DK, Schmidt M, von KC, Gaspar HB, Thrasher AJ (2009). Insertional mutagenesis combined with acquired somatic mutations causes leukaemogenesis following gene therapy of SCID-X1 patients. Journal of Clinical Investigation, 118(9), 3143 - 3150.
    • Howe S, Bartolovic K, Milsom M, Thrasher A, Kinnon C (2009). Optimisation of integration-deficient lentivirus (IDLV) application in hematopoietic stem cells. Human Gene Therapy, 20(11), 1463 - 1463.
    • Mukherjee S, Blundell MP, Bouma G, Kinnon C, Thrasher AJ (2009). A Comparative Study of Non-Integrating and Integrating Lentiviral Vectors in Eliciting an Effective Immune Response Against Hepatitis B Surface Antigen in Mice.
    • Ward NJ, Apolonia L, Cochrane M, Buckley SM, Waddington SN, Nathwani AC, Philpott NJ, Kinnon C, Thrasher AJ (2009). Nonintegrating Lentiviral Vectors for Treatment of Haemophilia B.
    • Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ (2009). Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc.Natl.Acad.Sci.U.S.A, 106(37), 15738 - 15743.

    2008

    • Thornhill SI, Grassman E, Ulaganathan M, Waddington SN, Howe SJ, Van Der Loo H, Schambach A, Kinnon C, Baum C, Williams D, Thrasher AJ (2008). Self-inactivating retroviral vectors for gene therapy of SCID-X1. Human Gene Therapy, 19(4), O15 - .
    • Howe SJ, Mansour M, Brugman M, Pike-Overzet K, Hubank M, Jina N, de Ridder D, Staal F, Baum C, Kinnon C, Gaspar HB, Thrasher AJ (2008). Molecular analysis of a severe adverse event in the UKSCID-X1 gene therapy clinical trial. Human Gene Therapy, 19(4), 82 - .
    • Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ (2008). Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.. Mol Ther, 16(3), 590 - 598. doi:10.1038/sj.mt.6300393
    • Santilli G, Thornhill SI, Kinnon C, Thrasher AJ (2008). Gene therapy of inherited immunodeficiencies. Expert.Opin.Biol Ther, 8(4), 397 - 407.
    • Blundell MP, Bouma G, Calle Y, Jones GE, Kinnon C, Thrasher AJ (2008). Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy. MOL THER, 16(5), 836 - 844. doi:10.1038/mt.2008.43
    • Santilli G, Blundell M, Haria S, Kinnon C, Antoniou M, Grez M, Thrasher A (2008). Evaluation of self-inactivating lentiviral vectors containing myeloid specific promoters in combination with the ubiquitously acting chromatin opening element (UCOE) for gene therapy of X-CGD.
    • Ward NJ, Apolonia L, Fernandes C, Waddington SN, Cochrane M, Nathwani AC, Thrasher AJ, Kinnon C, Philpott NJ (2008). Non-integrating lentiviral vector pseudotypes for safer gene therapy.
    • Howe SJ, Mansour M, Brugman M, Pike-Overzet K, Hubank M, Jina N, de Ridder D, Staal F, Baum C, Kinnon C, Gaspar HB, Thrasher AJ (2008). Molecular analysis of a severe adverse event in the UKSCID-X1 gene therapy clinical trial.
    • Thornhill SI, Grassman E, Ulaganathan M, Waddington SN, Howe SJ, Van Der Loo H, Schambach A, Kinnon C, Baum C, Williams D, Thrasher AJ (2008). Self-inactivating retroviral vectors for gene therapy of SCID-X1.

    2007

    • Barker SE, Grosse S, Siapati KE, Kritz A, Kinnon C, Thrasher AJ, Hart SL (2007). Immunotherapy for Neuroblastoma Delivered by Syngeneic Fibroblasts Transfected with IL-2 and IL-12.. British Journal of Cancer, 97(2), 210 - 217. doi:10.1038/sj.bjc.6603857
    • Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, Sinclair J, Kinnon C, Gaspar HB, Antoniou M, Thrasher AJ (2007). Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. Blood, 110(5), 1448 - 1457.
    • Karlsson H, Brewin J, Kinnon C, Veys P, Amrolia PJ (2007). Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogens. J Immunother (1997), 30 (5), 544 - 556.
    • Qasim W, Mackey T, Sinclair J, Chatziandreou I, Kinnon C, Thrasher AJ, Gaspar HB (2007). Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction. Molecular Therapy, 15(2), 355 - 360. doi:10.1038/sj.mt.6300042
    • Zhang F, Thornhill S, Howe SJ, Schambach A, Gaspar B, Kinnon C, Antoniou M, Thrasher A (2007). A novel UCOE promoter provides reproducible and stable transgene expression.
    • Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff P, Kinnon C, Jones GE, Thrasher AJ (2007). Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. Journal of Experimental Medicine, 204(9), 2213 - 2224. doi:10.1084/jem.20062324
    • Marshall CJ, Sinclair JC, Thrasher AJ, Kinnon C (2007). Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro. British Journal of Haematology, 139(2), 321 - 330. doi:10.1111/j.1365-2141.2007.06795.x
    • Ward N, Apolonia L, Fernandes C, Waddington S, Cochrane M, Kinnon C, Thrasher A, Nathwani AC, Philpott N (2007). Non-integrating lentiviral vector pseudotypes for safer gene therapy.
    • Schwarzwaelder K, Howe SJ, Schmidt M, Brugman M, Deichmann A, Glimm H, Schmidt S, Prinz C, Wissler M, King DJ, Zhang F, Parsley K, Gilmour KC, Sinclair J, Bayford J, Peraj R, de Ridder D, Pike-Ovezet K, Wagemaker G, Kinnon C, Abel U, Staal F, Gaspar HB, Thrasher AJ, von Kalle C (2007). Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.. Journal of Clinical Investigation, 117(8), 2241 - 2249. doi:10.1172/JCI31661

    2006

    • Bailey SI, Howe S, Schambach A, Bohne J, Kinnon C, Baum C, Thrasher AJ (2006). Investigating novel retroviral vectors for the treatment of SCID-X1.
    • Howe SJ, Schmidt M, Schwarzwaelder K, Deichmann A, Glimm H, Parsley K, Gilmour HB, Gaspar HB, Kinnon C, Thrasher AJ, Howe AJ (2006). Analysis of retroviralintegration sites in a SCID-X1 gene therapy trial.
    • Yanez-Munoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, Duran Y, Bartholomae C, Von Kalle C, Heckenlively JR, Kinnon C, Ali RR, Thrasher AJ (2006). Effective gene therapy with non-integrating lentiviral vectors. Nature Medicine, 12(3), 348 - 353. doi:10.1038/nm1365
    • Chatziandreou I, Gilmour KC, McNicol AM, Costabile M, Sinclair J, Cubitt D, Campbell JD, Kinnon C, Qasim W, Bobby GH (2006). Capture and generation of adenovirus specific T cells for adoptive immunotherapy. Br J Haematol, , - .
    • Gaspar HB, Bjorkegren E, Parsley K, Gilmour KC, King D, Sinclair J, Zhang F, Giannakopoulos A, Adams S, Fairbanks LD, Gaspar J, Henderson L, Xu-Bayford JH, Davies EG, Veys PA, Kinnon C, Thrasher AJ (2006). Successful Reconstitution of Immunity in ADA-SCID by Stem Cell Gene Therapy Following Cessation of PEG-ADA and Use of Mild Preconditioning. Mol Ther., 14(4), 505 - 513.
    • Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ (2006). Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.. Blood, 108(7), 2182 - 2189. doi:10.1182/blood-2006-01-010249
    • Kinnon C (2006). Gene therapy: has it delivered what it promised?. BR J HOSP MED (LOND), 67(5), 228 - 229.

    2005

    • Gaspar HB , Bjorkegren E , Parsley K , Gilmour KC , Sinclair J , Zhang F , Fairbanks LD , King D , Davies G , Veys P , Kinnon C , Thrasher AJ (2005). Somatic gene therapy for ADA-SCID following cessation of PEG-ADA and use of a mild conditioning regime.
    • Blundell MP, Charrier S, Kinnon C, Galy A, Thrasher AJ (2005). Lentiviral gene therapy for Wiskotot Aldrich Syndrome.
    • Yanez RJ, Balaggan KS, Smith AJ, Buch P, Howe S, MacNeilA D, Y A, P N K, C A, R R T, A J (2005). Effective Gene Therapy with Non-Integrating Lentiviral Vectors.
    • Gaspar HB, Bjorkegren E, Parsley K, Gilmour KC, Sinclair J, Zhang F, Fairbanks LD, King D, Davies G, Veys P, Kinnon C, Thrasher AJ (2005). Somatic gene therapy for ADA-SCID following cessation of PEG-ADA and use of a mild conditioning regime.
    • Parsley KL, Gaspar HB, Howe S, King D, Gilmour KG, Zhang F, Sinclair J, Von Kalle C, Ali RR, Kinnon C, Thrasher AJ (2005). Update on treatment of human SCID-X1 by somatic gene therapy using a pseudotyped gammaretroviral vector.
    • Gaspar HB, Bjorkegren E, Parsley K, Gilmour KC, Sinclair J, Zhang F, Fairbanks L, King D, Davies EG, Veys P, Kinnon C, Thrasher AJ (2005). Somatic Gene Therapy for ADA-SCID following cessation of PEG-ADA and use of a mild conditioning regime.

    2004

    • Kritz AB, Writer M, Kinnon C, Hart SL (2004). Peptides from phage display libraries for targeted gene delivery via the p75 neurotrophic receptor (p75NTR). The Journal of Gene Medicine, 6(9), 22 - .
    • Gaspar HB, Parsley K, Howe S, Gilmour K, Sinclair J, Barington A, Algonaim A, Davies G, Kinnon C, Thrasher A (2004). Update on treatment of human SCID-X1 by somatic gene therapy using a pseudotyped gammaretroviral vector.
    • Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J, Brouns G, Schmidt M, Von Kalle C, Barington T, Jakobsen MA, Christensen HO, Al Ghonaium A, White HN, Smith JL, Levinsky RJ, Ali RR, Kinnon C, Thrasher AJ (2004). Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. The Lancet, 364(9452), 2181 - 2187. doi:10.1016/S0140-6736(04)17590-9
    • de Noronha S, Hardy S, Sinclair J, Blundell MP, Strid J, Schulz O, Zwirner J, Jones GE, Katz DR, Kinnon C, Thrasher AJ (2004). Impaired dendritic cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. Blood, 105(4), 1590 - 1597. doi:10.1182/blood-2004-06-2332
    • Schwickerath O, Brouns G, Thrasher A, Kinnon C, Roes J, Casimir C (2004). Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD. The Journal of Gene Medicine, 6(6), 603 - 615.
    • Kritz AB, Writer M, Kinnon C, Hart SL (2004). Peptides from phage display libraries for targeted gene delivery via the p75 neurotrophic receptor (p75NTR).
    • Sharifi R, Sinclair J, Gilmour KC, Arkwright PD, Kinnon C, Thrasher AJ, Gaspar HB (2004). SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease. Blood, 103(10), 3821 - 3827. doi:10.1182/blood-2003-09-3359

    2003

    • Uduehi A, Mailhos C, Truman H, Thrasher A, Kinnon C, Hart SL (2003). Enhancement of integrin-mediated transfection of haematopoietic cells with a synthetic vector system. Biotechnology and Applied Biochemistry, 38, 201 - 209.
    • Qasim W, Thrasher A, Buddle J, King D, Kinnon C, Gaspar H (2003). Retroviral transduction and selection of T-cells for suicide gene therapy.
    • Qasim W, Kinnon C, King D, Thrasher AJ, Gaspar B (2003). Analysis of T cell functionality following retroviral mediated suicide gene transfer.
    • Writer MJ, Hsu C, Devitt J, Tabor AB, Kinnon C, Von Seggern D, Hart SL (2003). Increased efficiency of gene transfer into dendritic cells using phage display-derived peptides.
    • Sharifi R, Buddle J, Gilmour KC, Kinnon C, Thrasher AJ, Gaspar B (2003). Cytotoxic T cell defects in x-linked Lymphoproliferative disease and reconstitution of abnormalities by SAP gene transfer.
    • Siapati KE, Barker S, Kinnon C, Michalski A, Anderson E, Brickell P, Thrasher AJ, Hart SL (2003). Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12.. British Journal of Cancer, 88(10), 1641 - 1648. doi:10.1038/sj.bjc.6600928
    • Qasim W, King D, Buddle J, Verfuerth S, Kinnon C, Thrasher AJ, Gaspar HB (2003). The impact of retroviral suicide gene transduction procedures on T cells. British Journal of Haematology, 123(4), 712 - 719. doi:10.1046/j.1365-2141.2003.04672.x

    2002

    • Kinnon C, Thrasher AJ (2002). Gene therapy for single gene disorders. In Brooks G (Ed.), Gene Therapy. The use of DNA as a drug (pp. 71 - 85). : Pharmaceutical Press.
    • Sharifi GR, Kinnon C, Thrasher A, Gaspar BH (2002). NK cells as new target for gene therapy; Using retroviral vectors as promising delivery system..
    • Qasim W, Thrasher AJ, Kinnon C, Black ME, Gaspar HB (2002). T-cell transduction, selection and suicide using an enhanced mutant thymidine kinase.
    • Qasim W, Thrasher AJ, Buddle J, Kinnon C, Black ME, Gaspar HB (2002). T cell transduction and suicide with an enhanced mutant thymidine kinase. GENE THER, 9(12), 824 - 827. doi:10.1038/sj/gt/3301690
    • Kinnon C, Gaspar HB (2002). Genetics of Inherited Immunodeficiency Diseases and Diagnostic Techniques. In (Ed.), Manual of Clinical Laboratory Immunology (pp. 810 - 812). : ASM Press.
    • Demaison C, Parsley K, Brouns G, Scherr M, Battmer K, Kinnon C, Grez M, Thrasher AJ (2002). High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Human Gene Therapy, 13(7), 803 - 813. doi:10.1089/10430340252898984
    • Jenkins G, Hart SL, Hodges RJ, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ (2002). Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung. Chest, 121(3 Supp), 102S - 104S.
    • Yong KL, Fahey A, Pahal G, Linch DC, Pizzey A, Thomas NSB, Jauniaux E, Kinnon C, Thrasher AJ (2002). Fetal haemapoietic cells display enhanced migration across endothelium. British Journal of Haematology, 116, 392 - 400. doi:10.1046/j.1365-2141.2002.03273.x
    • Parsley K, Gilmour K, Brouns G, Howe S, Buddle J, King D, Kinnon C, Gaspar B, Thrasher AJ (2002). Successful treatment of human X-SCID using a GALV-pseudotyped retroviral vector. BLOOD CELL MOL DIS, 28(3), 345 - 346.

    2001

    • Gilmour KC, Davies EG, Jones A, Gaspar HB, Cranston T, Loughlin S, Lester T, Gwyther J, Kinnon C, Espanol T, Hernandez M, Savoldi G, Abinun M (2001). Rapid protein-based assays for the diagnosis of TB severe combined immunodeficiency. British Journal of Haematology, 112(3), 671 - 676. doi:10.1046/j.1365-2141.2001.02578.x
    • Qasim W, Gilmour KC, Ashton E, Graham Davies E, Thrasher AJ, Jones A, Gaspar HB, Kinnon C, Heath S, Cranston T, Thomas A, Finn A (2001). Protein assays for diagnosis of Wiskott-Aldrich syndrome and X-linked thrombocytopenia. British Journal of Haematology, 113(4), 861 - 865. doi:10.1046/j.1365-2141.2001.02832.x
    • Gaspar B, Sharifi R, Kinnon C, Peter A, Adrian T (2001). Sap gene transfer restores cytotoxic function in EBV-CTLS generated from individuals with XLP.. BLOOD, 98(11), 785A - 785A.
    • Gaspar B, Qasim W, Black M, Kinnon C, Thrasher A (2001). T cell suicide system: Improved transduction and an enhanced suicide gene system.. BLOOD, 98(11), 421A - 421A.
    • Gilmour K , Fujii H CT, Davies EG, Kinnon C , Gaspar HB (2001). Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell - deficient form of severe combined immunoodefiency. Blood, 98(3), 877 - 879.
    • Qasim W, Gilmour KC, Heath S, Ashton E, Cranston T, Thomas A, Finn A, Davies EG, Thrasher AJ, Kinnon C, Jones A, Gaspar HB (2001). Protein assays for diagnosis of Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Br.J Haematol., 113(4), 861 - 865.
    • Leverrier Y, Lorenzi R, Blundell MP, Brickell P, Kinnon C, Ridley AJ, Thrasher AJ (2001). Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells.. The Journal of Immunology, 166(8), 4831 - 4834.
    • Gaspar HB, Kinnon C (2001). X-linked agammaglobulinemia. IMMUNOL ALLERGY CLIN, 21(1), 23 - +.
    • Gilmour KC, Cranston T, Loughlin S, Gwyther J, Lester T, Espanol T, Hernandez M, Savoldi G, Davies EG, Abinun M, Kinnon C, Jones A, Gaspar HB (2001). Rapid protein-based assays for the diagnosis of T-B+ severe combined immunodeficiency. Br.J Haematol., 112(3), 671 - 676.
    • (2001). Screening for genetic defects in primary immunodeficiencies. CPD Bulletin Immunology and Allergy, 2, 3 - 7.
    • Estruch EJ, Hart SL, Kinnon C, Winchester BG (2001). Non-viral, integrin-mediated gene transfer into fibroblasts from patients with lysosomal storage diseases. The Journal of Gene Medicine, 3(5), 488 - 497.

    2000

    • Gilmour KC, Cranston T , Jones AM , Davies EG, Goldblatt D , Thrasher AJ , Kinnon C , Nichols KE , Gaspar HB (2000). Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression.. Eur.J.Immun., 30(6), 1691 - 1697.
    • Gaspar HB, Ferrando M, Caragol I, Hernandez M, Bertran JM, De gracia X, Lester T, Kinnon C, Ashton E, Espanol T (2000). Kinase mutant Btk results in atypical X-linked agammaglobulinaemia phenotype. Clinical and Experimental Immunology, 120(2), 346 - 350.
    • Jenkins RG, Herrick SE, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ, Hart SL (2000). An integrin-targetted non-viral vector for pulmonary Gene Therapy. Gene Therapy, 7, 393 - 400.
    • Kinnon C, Gaspar HB (2000). Genetics of inherited immunodeficiency diseases and diagnostic techniques. In (Ed.), Manual for Clinical Laboratory Immunology (pp. - ). : .
    • Lorenzi R, Brickell P, Katz DR, Kinnon C, Thrasher AJ (2000). Wiskott-Aldrich syndrome protein is necessary for effecient IgG-mediated phagocytosis. BLOOD, 95, 2943 - 2946.
    • Thrasher AJ, Kinnon C (2000). The Wiskott-Aldrich syndrome. Clinical and Experimental Immunology, 120, 2 - 9.
    • Pahal GS, Jauniaux ER, Kinnon C, Thrasher A, Rodeck CH (2000). Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation. American Journal of Obstetrics and Gynecology, 183, 1029 - 1034.
    • Demaison C, Brouns G, Blundell MP, Goldman JP, Levinsky RJ, Grez M, Kinnon C, Thrasher AJ (2000). A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus pseudotyped retroviral vector. Human Gene Therapy, 11(1), 91 - 100.
    • Jenkins RG, Hart SL, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ (2000). Optimising lid vector complex preparation leads to enhanced gene expression in the lung..
    • (2000). Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nature Genetics, 25(3), 306 - 310.
    • White H, Thrasher A, Veys P, Kinnon C, Gaspar HB (2000). Intrinsic defects of B cell function in X-linked severe combined immunodeficiency. European Journal of Immunology, 30(3), 732 - 737.
    • Marshall CJ, Kinnon C, Thrasher AJ (2000). Polarised expression of bone morphogenic protein-4 in the human aorta-gonad-mesonephros region. BLOOD, 96, 1591 - 1593.

    1999

    • White H, Thrasher AJ, Veys PA, Kinnon C, Gaspar HB (1999). Analysis of intrinsic defects of B-cell function in X-linked severe combined immunodeficiency.. BLOOD, 94(10), 617A - 617A.
    • Marshall CJ, Moore RL, Thorogood P, Brickell PM, Kinnon C, Thrasher AJ (1999). Detailed characterisation of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a haematopoietic stromal layer.. BLOOD, 94(10), 130B - 130B.
    • Blundell MP, Demaison C, Brouns G, Goldman JP, Gaspar HB, Kinnon C, Thrasher AJ, Lazzari L, Sirchia G (1999). Quality of repopulation in nonobese diabetic severe combined immunodeficient mice engrafted with expanded cord blood CD34(+) cells. Blood, 94(9), 3269 - 3270.
    • Brouns G, Demaison C, Blundell M, Goldman J, Levinsky RJ, Grez M, Kinnon C, Thrasher AJ (1999). Evidence for human myeloid-restricted haematopoietic stem cells. British Journal of Haematology, 105, 284 - .
    • Jenkins RG, Hart SL, Chambers RC, Herrick SE, Kinnon C, Laurent GJ, McAnulty RJ (1999). Enhanced gene delivery to the lung using a novel integrin mediated vector.
    • MacCarthy-Morrogh LM, Hinshelwood S, Costello P, Cory GO, Kinnon C (1999). The SH3 domain of Bruton's tyrrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. European Journal of Immunology, 29(7), 2269 - 2279.
    • Marshall CJ, Moore R, Thorogood P, Brickell PM, Kinnon C, Thrasher AJ (1999). Detailed characterisation of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer. Developmental Dynamics, 215, 139 - 147.
    • O'Sullivan E, Kinnon C, Brickell P (1999). Wiskott-Aldrich syndrome protein, WASP. The International Journal of Biochemistry and Cell Biology, 31(3-4), 383 - 387.
    • Brouns G, Demaison C, Blundell M, Goldman J, Levinsky RJ, Grez M, Kinnon C, Thrasher AJ (1999). Evidence for human myeloid-restricted haematopoietic stem cells.. BRIT J HAEMATOL, 105, 101 - 101.
    • Marshall CJ, Moore RL, Thorogood P, Brickell PM, Kinnon C, Thrasher AJ (1999). Detailed characterisation of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a haematopoietic stromal layer. BRIT J HAEMATOL, 105, 103 - 103.
    • Zhang X, De Alwis M, Hart SL, Fitzke FW, Inglis SC, Boursnell ME, Levinsky RJ, Kinnon C, Ali RR, Thrasher AJ (1999). High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H.. Hum Gene Ther, 10(15), 2527 - 2537. doi:10.1089/10430349950016861

    1998

    • Goldsack NR, Chambers RC, Blanc-Brude OP, Laurent GJ, McAnulty RJ, Hart SL, Kinnon C (1998). Integrin mediated uptake of antisense oligonucleotides to the PAR-1 thrombin receptor inhibits thrombin induced fibroblast proliferation. FASEB Journal, 12(4), - .
    • Goldman JP, Blundell MP, Lopes L, Kinnon C, Di Santo JP, Thrasher AJ (1998). Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain.. Br J Haematol, 103(2), 335 - 342.
    • Binks MH, Jones JE, Brickell PM, Kinnon C, Katz DR, Thrasher AJ (1998). Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome. European Journal of Immunology, 28, 3259 - 3267.
    • Thrasher AJ, Jones G, Kinnon C, Brickell PM, Katz DR (1998). Is Wiskott-Aldrich syndrome a cell trafficking disorder?. Immunology Today, 19, 537 - 539.
    • Gaspar HB, Lester T, Levinsky RJ, Kinnon C (1998). Analysis of Bruton's tyrosine kinase protein expression and activity in patients with X-linked agammaglobulinemia (XLA):the use of protein analysis as a diagnostic indicator of XLA. Clinical and Experimental Immunology, 111(2), 334 - 338.
    • Ali RR, Reichel MB, De Alwis M, Kanuga N, Kinnon C, Levinsky RJ, Hunt DM, Bhattacharya SS, Thrasher AJ (1998). Adeno-associated virus gene transfer to mouse retina.. Hum Gene Ther, 9(1), 81 - 86. doi:10.1089/hum.1998.9.1-81
    • Thrasher AJ, Binks M, Kinnon C, Katz DR, Brickell PM, Jones GE (1998). Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome.. J LEUKOCYTE BIOL, , 52 - 52.
    • Gaspar HB, Lester T, Levinsky RJ, Kinnon C (1998). Bruton's tyrosine kinase expression and activity in X-linked agammaglobulinaemia (XLA): the use of protein analysis as a diagnostic indicator of XLA.. Clin Exp Immunol, 111(2), 334 - 338.
    • Hart SL, Arancibia-Cárcamo CV, Wolfert MA, Mailhos C, O'Reilly NJ, Ali RR, Coutelle C, George AJ, Harbottle RP, Knight AM, Larkin DF, Levinsky RJ, Seymour LW, Thrasher AJ, Kinnon C (1998). Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector.. Hum Gene Ther, 9(4), 575 - 585. doi:10.1089/hum.1998.9.4-575
    • Gaspar HB, Goldman JP, Blundell MP, Kinnon C, DiSanto JP, Thrasher AJ (1998). Enhanced human cell engraftment in mice deficient in RAG2 and the common gamma chain. BONE MARROW TRANSPL, 21, S75 - S75.
    • Goldsack NR, Chambers RC, Blanc-Brude OP, Hart SL, Kinnon C, Laurent GJ, McAnulty RJ (1998). Integrin mediated uptake of antisense oligonucleotides to the PAR-1 thrombin receptor inhibits thrombin induced fibroblast proliferation..
    • Zicha D, Allen WE, Brickell PM, Kinnon C, Dunn GA, Jones GE, Thrasher AJ (1998). Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. BRIT J HAEMATOL, 101(4), 659 - 665.
    • MacCarthy-Morrogh L, Gaspar HB, Wang YC, Katz F, Thompson L, Layton M, Jones AM, Kinnon C (1998). Absence of expression of the Wiskott-Aldrich syndrome protein in peripheral blood cells of Wiskott-Aldrich syndrome patients.. Clin Immunol Immunopathol, 88(1), 22 - 27.
    • Binks M, Jones GE, Brickell PM, Kinnon C, Katz DR, Thrasher AJ (1998). Intrinsic dendritic cell defects in Wiskott-Aldrich syndrome.. MOL IMMUNOL, 35(11-12), 734 - 734.
    • Goldman JP, Blundell MP, Kinnon C, DiSanto JP, Thrasher AJ (1998). Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain. MOL IMMUNOL, 35(11-12), 779 - 779.
    • Gaspar HB, Macarthy-Morrogh L, Ashton E, Lester T, Katz F, Jones AM, Kinnon C (1998). Protein expression in primary immunodeficiencies: The use of protein analysis as a diagnostic indicator of immunodeficiency. MOL IMMUNOL, 35(11-12), 725 - 725.
    • Jenkins RG, Chambers RC, Herrick SE, Laurent GJ, Mcanulty RJ, Hart SL, Kinnon C (1998). Integrin-targeting vectors are efficient vehicles for delivery of DNA to the lung.

    1997

    • Kinnon C, Levinsky RJ (1997). Genetics of inherited immunodeficiency diseases and diagnostic techniques. In Cunningham-Rundles C (Ed.), Manual of Clinical Laboratory Immunology (pp. 815 - 823). : American Society for Microbiology.
    • Kinnon C, Jones AM (1997). Genetics of inherited immunodeficiencies I: X-linked disorders. BMJ (Clinical Research Ed.), 57, 364 - 366.
    • Jones AM, Clark PA, Katz F, Genet S, McMahon C, Alterman L, Cant A, Kinnon C (1997). B-cell-negative severe combined immunodeficiency associated with a common chain mutation. Human Genetics, 99, 677 - 680.
    • Thrasher AJ, Goldman J, de Alwis M, Porter CD, Kinnon C (1997). Gene therapy for primary immunodeficiency.. Biochem Soc Trans, 25(2), 537 - 540.
    • Kinnon C, Cory GOC, MacCarthy-Morrogh L, Banin S, Gout I, Lovering RC, Brickell PM (1997). The identification of Bruton's tyrosine kinase and Wiskott-Aldrich syndrome protein associated proteins and signalling pathways. Biochemical Society Transactions, 25, 648 - 650.
    • Lovering RC, Hinshelwood S, Kinnon C (1997). X-linked agammaglobulinaemia, an inherited deficiency of antibody production. In Harnett M, Rigley KP (Ed.), Lymphocyte Signalling:Mechanisms, subversion and manipulation (pp. 339 - 357). : John Wiley and Sons.
    • Maas A, Dingjan GM, Savelkoul HFJ, Kinnon C, Grosveld F, Hendriks RW (1997). The X-linked immunodeficiency defect in the mouse is corrected by expression of human Bruton's tyrosine kinase from a yeast artificial chromosome transgene. European Journal of Immunology, 27, 2180 - 2187.
    • Kinnon C, Jones AM (1997). Genetics of inherited immunodeficiencies II: Autosomal recessive disorders. BMJ (Clinical Research Ed.), 57, 424 - 426.

    1996

    • Schwarz K, Fugmann S, Nonoyama S, Peitsch MC, De Saint Basile G, Fischer A, Espanol T, Fasth A, Freitag K, Friedrich W, Hossle H-P, Wechsler A, Jones A, Kinnon C, Meindl A, Notarangelo LD, Weiss M, Ochs HD (1996). WASPbase: A database of WAS- and XLT-causing mutations. Immunology Today, 17(11), 496 - 502. doi:10.1016/0167-5699(96)30061-3
    • Kinnon C (1996). Genes in diagnosis and therapy. Hospital Medicine, 56(4), - .
    • Vihinen M, Iwata T, Kinnon C, Kwan S-P, Ochs HD, Vořechovský I, Edvard Smith CI (1996). BTKbase, mutation database for X-linked agammaglobulinemia (XLA). Nucleic Acids Research, 24(1), 157 - 159.
    • Porter CD, Kuribayashi F, Parkar MH, Roos D, Kinnon C (1996). Detection of gp91-phox precursor in B-cell lines from patients with X-linked chronic granulomatosis disease as an indicator for cytochrome b558 biosynthesis. Biochemical Journal, 315(2), 571 - 575.
    • Porter CD, Parkar MH, Kinnon C (1996). Identification of a donor splice site mutation leading to loss of p22-phox exon 5 in autosomal chronic granulomatous disease.
    • Porter CD, Parkar MH, Collins MLK, Levinsky RJ, Kinnon C (1996). Efficient retroviral transduction of human bone marrow progenitor and long-term culture initiating cells: partial reconstitution of cells from patients with X-linked chronic granulomatous disease by gp91-phox expression. Blood, 87(9), 3722 - 3730.
    • Kinnon C (1996). The identification of BTK associated proteins and signalling pathways. IMMUNOLOGY, 89, SAA80 - SAA80.
    • Vihinen M, Iwata T, Kinnon C, Kwan SP, Ochs HD, Vorechovský I, Smith CI (1996). BTKbase, mutation database for X-linked agammaglobulinemia (XLA).. Nucleic Acids Res, 24(1), 160 - 165.
    • Ali RR, Reichel MB, Thrasher AJ, Levinsky RJ, Kinnon C, Kanuga N, Hunt DM, Bhattacharya SS (1996). Gene transfer into the mouse retina mediated by an adeno-associated viral vector.. Hum Mol Genet, 5(5), 591 - 594.
    • Jones A, Bradley L, Alterman L, Tarlow M, Thompson R, Kinnon C, Morgan G (1996). X linked agammaglobulinaemia with a 'leaky' phenotype.. Arch Dis Child, 74(6), 548 - 549.
    • Kinnon C (1996). Genes in diagnosis and therapy.. Br J Hosp Med, 56(4), 132 - 135.
    • Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (1996). Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.. J Immunol, 157(9), 3791 - 3795.
    • Notarangelo LD, Peitsch MC, Abrahamsen TG, Bachelot C, Bordigoni P, Cant AJ, Chapel H, Clementi M, Deacock S, de Saint Basile G, Duse M, Espanol T, Etzioni A, Fasth A, Fischer A, Giliani S, Gomez L, Hammarstorm L, Jones A, Kanariou M, Kinnon C, Klemola T, Kroczek RA, Levy J, Matamoros N, Monafo V, Paolucci P, Reznick I, Sanal O, Smith CI, Thompson RA, Tovo P, Villa A, Vihinen M, Vossen J, Zegers BJ (1996). CD40lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome.. Immunol Today, 17(11), 511 - 516.
    • Katz F, Hinshelwood S, Rutland P, Jones A, Kinnon C, Morgan G (1996). Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome.. Hum Mutat, 8(3), 223 - 228. doi:10.1002/(SICI)1098-1004(1996)8:3<223::AID-HUMU5>3.0.CO;2-A

    1995

    • Kinnon C, Lovering R, O'Reilly MA, Sweatman A, Bradley L, Parkar M, Alterman L, Levinsky R (1995). Physical and genetic approaches to the isolation of the gene for X-linked agammaglobulinemia.. Immunodeficiency, 5(3), 179 - 185.
    • Matthews DJ, Clark PA, Herbert J, Morgan G, Armitage RJ, Kinnon C, Minty A, Grabstein KH, Caput D, Ferrara P (1995). Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.. Blood, 85(1), 38 - 42.
    • Kinnon C (1995). Inherited immunodeficiencies.. Mol Cell Biol Hum Dis Ser, 5, 157 - 174.
    • THRASHER A, DEALWIS M, CASIMIR C, KINNON C, SEGAL A, PAGE K, LEBKOWSKI J, LEVINSKY R (1995). DEVELOPMENT OF ADENOASSOCIATED VIRUS VECTORS FOR GENE-THERAPY OF CHRONIC GRANULOMATOUS-DISEASE. J CELL BIOCHEM, , 433 - 433.
    • Gaspar HB, Bradley LA, Katz F, Lovering RC, Roifman CM, Morgan G, Levinsky RJ, Kinnon C (1995). Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot.. Hum Mol Genet, 4(4), 755 - 757.
    • Hinshelwood S, Lovering RC, Genevier HC, Levinsky RJ, Kinnon C (1995). The protein defective in X-linked agammaglobulinemia, Bruton's tyrosine kinase, shows increased autophosphorylation activity in vitro when isolated from cells in which the B cell receptor has been cross-linked.. Eur J Immunol, 25(4), 1113 - 1116. doi:10.1002/eji.1830250439
    • Thrasher A, Kinnon C (1995). Gene therapy for primary immunodeficiency.. Gene Ther, 2(9), 601 - 602.
    • THRASHER AJ, DEALWIS M, CASIMIR CM, KINNON C, PAGE K, LEBKOWSKI J, SEGAL AW, LEVINSKY RJ (1995). FUNCTIONAL RECONSTITUTION OF THE NADPH-OXIDASE BY ADENOASSOCIATED VIRUS GENE-TRANSFER. BLOOD, 86(2), 761 - 765.
    • Cory GO, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C (1995). The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.. J Exp Med, 182(2), 611 - 615.
    • Thrasher AJ, de Alwis M, Casimir CM, Kinnon C, Page K, Lebkowski J, Segal AW, Levinsky RJ (1995). Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase.. Gene Ther, 2(7), 481 - 485.
    • Clark PA, Lester T, Genet S, Jones AM, Hendriks R, Levinsky RJ, Kinnon C (1995). Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis.. Hum Genet, 96(4), 427 - 432.
    • Vihinen M, Cooper MD, de Saint Basile G, Fischer A, Good RA, Hendriks RW, Kinnon C, Kwan SP, Litman GW, Notarangelo LD (1995). BTKbase: a database of XLA-causing mutations. International Study Group.. Immunol Today, 16(10), 460 - 465.
    • VIHINEN M, COOPER MD, DESAINTBASILE G, FISCHER A, GOOD RA, HENDRIKS RW, KINNON C, KWAN SP, LITMAN GW, NOTARANGELO LD, OCHS HD, ROSEN FS, VETRIE D, WEBSTER ADB, ZEGERS BJM, SMITH CIE (1995). BTKBASE - A DATABASE OF XLA-CAUSING MUTATIONS. IMMUNOL TODAY, 16(10), 460 - 465.
    • THRASHER AJ, CASIMIR CM, KINNON C, MORGAN G, SEGAL AW, LEVINSKY RJ (1995). GENE-TRANSFER TO PRIMARY CHRONIC GRANULOMATOUS-DISEASE MONOCYTES. LANCET, 346(8967), 92 - 93.

    1994

    • Kinnon C (1994). Gene transfer into haematopioetic progenitors. Bone Marrow Transplantation, 14(SUPPL. 2), - .
    • Genevier HC, Hinshelwood S, Gaspar HB, Rigley KP, Brown D, Saeland S, Rousset F, Levinsky RJ, Callard RE, Kinnon C (1994). Expression of Bruton's tyrosine kinase protein within the B cell lineage.. Eur J Immunol, 24(12), 3100 - 3105. doi:10.1002/eji.1830241228
    • Sweatman AK, Bradley LA, Lovering RC, O'Reilly MA, Levinsky RJ, Kinnon C (1994). Physical mapping in the region of the Bruton's tyrosine kinase and alpha-galactosidase A gene loci in proximal Xq22.. Hum Genet, 94(6), 624 - 628.
    • Parkar MH, Lovering R, Levinsky RJ, Kinnon C (1994). Genetic mapping of two loci, DXS454 and DXS458, with respect to the X-linked agammaglobulinemia gene locus. Human Genetics, 93(1), 89 - 90.
    • Bradley LA, Sweatman AK, Lovering RC, Jones AM, Morgan G, Levinsky RJ, Kinnon C (1994). Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis.. Hum Mol Genet, 3(1), 79 - 83.
    • Porter CD, Parkar MH, Verhoeven AJ, Levinsky RJ, Collins MKL, Kinnon C (1994). p22-phox-deficient chronic granulomatous disease: reconstitution by retrovirus-mediated expression and identification of a biosynthetic intermediate of gp91-phox. Blood, 84(8), 2767 - 2775.
    • Katz FE, Lovering RC, Bradley LA, Rigley KP, Brown D, Cotter F, Chessells JM, Levinsky RJ, Kinnon C (1994). Expression of the X-linked agammaglobulinemia gene, btk in B-cell acute lymphoblastic leukemia.. Leukemia, 8(4), 574 - 577.
    • Clark PA, Lester T, Villard L, Fontes M, Kinnon C (1994). Deletion mapping of the DXS986, DXS995, and DXS1002 loci defines their order within Xq21.. J Med Genet, 31(4), 344 - 345.
    • Lovering RC, Sweatman A, Genet SA, Middleton-Price HR, Vetrie D, Vorechovsky I, Bentley D, Fontan G, Español T, Morgan G (1994). Identification of deletions in the btk gene allows unambiguous assessment of carrier status in families with X-linked agammaglobulinaemia.. Hum Genet, 94(1), 77 - 79.
    • Lester T, de Alwis M, Clark PA, Jones AM, Katz F, Levinsky RJ, Kinnon C (1994). Trisomy X in a female member of a family with X linked severe combined immunodeficiency: implications for carrier diagnosis.. J Med Genet, 31(9), 717 - 720.
    • de Weers M, Brouns GS, Hinshelwood S, Kinnon C, Schuurman RK, Hendriks RW, Borst J (1994). B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.. J Biol Chem, 269(39), 23857 - 23860.
    • KINNON C (1994). PROSPECTS FOR GENE-THERAPY OF X-LINKED IMMUNODEFICIENCY DISEASES.

    1993

    • Jones A, Morris T, de Alwis M, Malcolm S, Levinsky RJ, Kinnon C (1993). Physical and genetic mapping in the region of Xq12-21, which contains the locus for X-linked severe combined immunodeficiency.. Immunodeficiency, 4(1-4), 259 - 262.
    • Alterman LA, de Alwis M, Genet S, Lovering R, Middleton-Price H, Morgan G, Jones A, Malcolm S, Levinsky RJ, Kinnon C (1993). Carrier determination for X-linked agammaglobulinemia using X inactivation analysis of purified B cells.. J Immunol Methods, 166(1), 111 - 116.
    • KINNON C, OREILLY MA, SWEATMAN A, BRADLEY L, ALTERMAN L, LOVERING R, MALCOLM S, LEVINSKY R (1993). PHYSICAL APPROACHES TO THE ISOLATION OF THE X-LINKED AGAMMAGLOBULINEMIA GENE (XLA). J CELL BIOCHEM, , 165 - 165.
    • LOVERING R, PADAYACHEE M, OREILLY MA, MIDDLETONPRICE H, GENET S, PARKAR M, ALTERMAN L, SWEATMAN A, BRADLEY L, MALCOLM S, LEVINSKY R, KINNON C (1993). GENETIC-LINKAGE ANALYSIS FOR X-LINKED AGAMMAGLOBULINEMIA (XLA) AND X-LINKED HYPER IGM (XHM). J CELL BIOCHEM, , 182 - 182.
    • Lovering R, Middleton-Price HR, O'Reilly M-AJ, Genet SA, Parkar MH, Sweatman AK, Bradley LD, Alterman LA, Malcolm S, Morgan G, Levinsky RJ, Kinnon C (1993). Genetic linkage analysis identifies new proximal and distal flanking markers for the X-linked agammaglobulinemia gene locus, refining its localization in Xq22. Human Molecular Genetics, 2(2), 139 - 141.
    • O'Reilly MA, Alterman LA, Zijlstra J, Malcolm S, Levinsky RJ, Kinnon C (1993). Pulsed-field gel electrophoresis and radiation hybrid mapping analyses enable the ordering of eleven DNA loci in Xq22.. Genomics, 15(2), 275 - 282. doi:10.1006/geno.1993.1057
    • Lovering R, Sweatman AK, O'Reilly MA, Genet SA, Middleton-Price H, Malcolm S, Levinsky RJ, Kinnon C (1993). Physical mapping identifies DXS265 as a useful genetic marker for carrier detection and prenatal diagnosis of X-linked agammaglobulinemia.. Hum Genet, 91(2), 178 - 180.
    • Padayachee M, Levinsky RJ, Kinnon C, Finn A, McKeown C, Feighery C, Notarangelo LD, Hendriks RW, Read AP, Malcolm S (1993). Mapping of the X linked form of hyper IgM syndrome (HIGM1). J Med Genet, 30(3), 202 - 205.
    • LEVINSKY RJ, PARKAR MH, COLLINS MKL, KINNON C, PORTER CD (1993). X-LINKED CHRONIC GRANULOMATOUS-DISEASE - CORRECTION OF NADPH OXIDASE DEFECTS BY RETROVIRUS-MEDIATED GENE-TRANSFER. J CELL BIOCHEM, , 232 - 232.
    • Sweatman A, Lovering R, Middleton-Price H, Jones A, Morgan G, Levinsky R, Kinnon C (1993). A new restriction fragment length polymorphism at the DXS101 locus allows carrier detection in a family with X linked agammaglobulinaemia.. J Med Genet, 30(6), 512 - 514.
    • Jones AM, Malcolm S, Levinsky RJ, Kinnon C (1993). Physical mapping in the region of human Xq12-21.1 using pulsed field gel electrophoresis.. Hum Genet, 91(5), 485 - 488.
    • O'Reilly MA, Sweatman AK, Bradley LD, Alterman LA, Lovering R, Malcolm S, Levinsky RJ, Kinnon C (1993). Isolation and mapping of discrete DXS101 loci in Xq22 near the X-linked agammaglobulinaemia gene locus.. Hum Genet, 91(6), 605 - 608.
    • Porter CD, Parkar MH, Levinsky RJ, Collins MKL, Kinnon C (1993). X-linked chronic granulomatous disease: correction of NADPH oxidase defect by retrovirus-mediated expression of gp91-phox. Blood, 82(7), 2196 - 2202.
    • Kinnon C, Hinshelwood S, Levinsky RJ, Lovering RC (1993). X-linked agammaglobulinemia--gene cloning and future prospects.. Immunol Today, 14(11), 554 - 558. doi:10.1016/0167-5699(93)90187-P
    • Vetrie D, Vorechovský I, Sideras P, Holland J, Davies A, Flinter F, Hammarström L, Kinnon C, Levinsky R, Bobrow M (1993). The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.. Nature, 361(6409), 226 - 233. doi:10.1038/361226a0

    1992

    • Kinnon C, Levinsky R (1992). The molecular basis of X-linked immunodeficiency disease.. J Inherit Metab Dis, 15(4), 674 - 682.
    • Porter CD, Parkar MH, Collins MK, Levinsky RJ, Kinnon C (1992). Superoxide production by normal and chronic granulomatous disease (CGD) patient-derived EBV-transformed B cell lines measured by chemiluminescence-based assays.. J Immunol Methods, 155(2), 151 - 157.
    • O'Reilly MA, Alterman LA, Malcolm S, Levinsky RJ, Kinnon C (1992). Identification of CpG islands around the DXS178 locus in the region of the X-linked agammaglobulinaemia gene locus in Xq22.. Hum Genet, 90(3), 275 - 278.
    • Padayachee M, Feighery C, Finn A, McKeown C, Levinsky RJ, Kinnon C, Malcolm S (1992). Mapping of the X-linked form of hyper-IgM syndrome (HIGM1) to Xq26 by close linkage to HPRT.. Genomics, 14(2), 551 - 553.

    1991

    • Kinnon C, O'Reilly MA, Pelham A, Malcolm S, Porter CD, Parkar MH, Collins MK, Leveinsky RJ (1991). Gene therapy for X-linked immunodeficiencies.. Allergol Immunopathol (Madr), 19(1), 32 - 37.
    • OREILLY MAJ, MALCOLM S, LEVINSKY RJ, KINNON C (1991). MAPPING OF THE X-LINKED AGAMMAGLOBULINEMIA LOCUS.
    • Rougon G, Alterman LA, Dennis K, Guo XJ, Kinnon C (1991). The murine heat-stable antigen: a differentiation antigen expressed in both the hematolymphoid and neural cell lineages.. Eur J Immunol, 21(6), 1397 - 1402. doi:10.1002/eji.1830210611
    • JONES AM, MALCOLM S, LEVINSKY RJ, KINNON C (1991). PHYSICAL MAPPING IN THE REGION XQ12-13. CYTOGENET CELL GENET, 58(3-4), 2068 - 2069.
    • OREILLY MAJ, ALTERMAN LA, ZIJLSTRA J, MALCOLM S, LEVINSKY RJ, KINNON C (1991). A PHYSICAL MAP OF XQ22, REFINING THE X-LINKED AGAMMAGLOBULINEMIA LOCUS. CYTOGENET CELL GENET, 58(3-4), 2077 - 2078.
    • PELHAM A, MALCOLM S, LEVINSKY RJ, KINNON C (1991). RFLP AND DELETION ANALYSIS FOR X-LINKED CHRONIC GRANULOMATOUS-DISEASE.

    1990

    • Kinnon C, O'Reilly MAJ, Pelham A, Malcolm S, Porter CD, Parkar MH, Collins MKL, Levinsky RJ (1990). Gene therapy for X-linked immunodeficiencies. Immunologia Clinica, 9(3), 103 - 111.
    • Kinnon C, Levinsky RJ (1990). Gene therapy for cancer.. Eur J Cancer, 26(5), 638 - 640.
    • Kinnon C, Levinsky RJ (1990). Somatic gene therapy for genetic disease.. Arch Dis Child, 65(1), 72 - 73.
    • Pelham A, Malcolm S, Levinsky RJ, Kinnon C (1990). An additional NsiI RFLP at the X-linked chronic granulomatous disease (CYBB) locus.. Nucleic Acids Res, 18(23), 7199 - .
    • O'Reilly MA, Kinnon C (1990). The technique of pulsed field gel electrophoresis and its impact on molecular immunology.. J Immunol Methods, 131(1), 1 - 13.
    • Pelham A, O'Reilly MA, Malcolm S, Levinsky RJ, Kinnon C (1990). RFLP and deletion analysis for X-linked chronic granulomatous disease using the cDNA probe: potential for improved prenatal diagnosis and carrier determination.. Blood, 76(4), 820 - 824.
    • Alterman LA, Crispe IN, Kinnon C (1990). Characterization of the murine heat-stable antigen: an hematolymphoid differentiation antigen defined by the J11d, M1/69 and B2A2 antibodies.. Eur J Immunol, 20(7), 1597 - 1602. doi:10.1002/eji.1830200728

    1989

    • Kinnon C, Katz F (1989). Immunoglobulin and T cell receptor gene rearrangement and expression in B cell acute lymphoblastic leukemia.. Leukemia, 3(11), 808 - 812.

    1987

    • Kinnon C, McGuire KL, Rothenberg EV (1987). Differential regulation of T cell receptor gamma genes in immature thymocyte populations.. Eur J Immunol, 17(9), 1265 - 1269. doi:10.1002/eji.1830170908

    1986

    • Kinnon C, Diamond RA, Rothenberg EV (1986). Activation of T cell antigen receptor alpha- and beta-chain genes in the thymus: implications for the lineages of developing cortical thymocytes.. J Immunol, 137(12), 4010 - 4015.
    • Kinnon C, Owen MJ (1986). The synthesis and expression of HLA-A and -B antigens in Xenopus laevis oocytes.. Mol Immunol, 23(5), 525 - 532.

    1984

    • COLLINS M, KINNON C (1984). THE LYMPHOCYTE MEMBRANE. IMMUNOL TODAY, 5(1), 1 - &.
    • Collins M, Kinnon C (1984). The lymphocyte membrane. Immunology Today, 5(1), - .

    1983

    • Kinnon C, Owen MJ (1983). Clathrin-coated vesicles purified from a human B lymphocyte cell line contain newly synthesized glycoproteins.. J Biol Chem, 258(13), 8470 - 8476.

    1981

    • Miller AL, Kress BC, Stein R, Kinnon C, Kern H, Schneider JA, Harms E (1981). Properties of N-acetyl-beta-D-hexosaminidase from isolated normal and I-cell lysosomes.. J Biol Chem, 256(17), 9352 - 9362.

    1980

    • Miller AL, Kress BC, Lewis L, Stein R, Kinnon C (1980). Effect of tunicamycin and cycloheximide on the secretion of acid hydrolases from I-cell cultured fibroblasts.. Biochem J, 186(3), 971 - 975.
    • MILLER AL, STEIN R, KINNON C, KERN H, SCHNEIDER JA, HARMS E (1980). ACID-HYDROLASES IN ISOLATED LYSOSOMES FROM CULTURED I-CELL FIBROBLASTS. FED PROC, 39(6), 2082 - 2082.