Dr Andre Strydom


Personal Profile

Name: Andre Strydom Email: a.strydom@ucl.ac.uk
Title: Dr Tel: 02076799308
Department: Division of Psychiatry Fax: 02076799426
Position: Reader in Intellectual Disabilities Address: Charles Bell House, 2nd Floor 67-73 Riding House Street, London, W1W 7EJ
Research Domain: Ageing, Experimental Medicine, Global Health, Neuroscience, Personalised Medicine, Populations & Lifelong Health Web Page: Personal Web Page


Research Description

Dr. Strydom's research concerns the epidemiology, etiology and clinical aspects of mental disorders in adults with neurodevelopmental disorders including intellectual disabilities, Autism & Asperger syndrome, and ADHD. He has a specific interest in conditions associated with ageing in these populations, such as the association between Alzheimer's disease and Down Syndrome.

Current projects and collaborations include the LonDownS consortium funded by the Wellcome Trust to study the neurobiology of Alzheimer's Disease in Down syndrome, the ADSID registry of dementia in older adults with Intellectual Disabilities and Down Syndrome, and a study exploring copy number variations associated with mental disorders in adults with non-syndromic intellectual disabilities (funded by the Baily Thomas Fund). He is an investigator on industry sponsored trials of new drug treatment options in Down syndrome (http://www.roche-trials.com/trialDetailsGet.action?studyNumber=BP25543) and fragile X syndrome.

Dr Strydom is also involved in developing and trialling complex interventions in adults with ID such as CBT for anxiety and depression, positive behaviour support for problem behaviours, and health checks for people with intellectual disabilities in primary care.

Research Activities

Ageing and mental health in adults with intellectual disabilities and other neurodevelopmental conditions

Cognitive change and Alzheimer's Disease in older adults with Down Syndrome

Genetics of Mental Disorders in adults with Intellectual Disabilities

Health services research including mixed methods evaluation of interventions for people with intellectual disabilities (ID) and mental health problems

Intellectual Disabilities

Education Description

Dr Strydom participates in teaching undergraduate medical students, psychiatry and psychology trainees and mentoring of young researchers in the Department of Mental Health Sciences.

UCL Collaborators

Prof Gill Livingston; Dr Zuzana Walker; Prof Michael King; Prof Nora Groce; Dr Marc Serfaty; Dr Katrina Scior; Prof Adrian Furnham

External Collaborators



    • Eady N, Courtenay K, Strydom A (2015). Pharmacological Management of Behavioral and Psychiatric Symptoms in Older Adults with Intellectual Disability. Drugs and Aging, , - . doi:10.1007/s40266-014-0236-7
    • Hithersay R, Strydom A, Buszewicz M (2015). Carer-led interventions for improving health in adults with intellectual disabilities. JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES, 28(1), 56 - 56.
    • Ali A, Kock E, Molteno C, Mfiki N, King M, Strydom A (2015). Ethnicity and self-reported experiences of stigma in adults with intellectual disability in Cape Town, South Africa.. J Intellect Disabil Res, 59(6), 530 - 540. doi:10.1111/jir.12158
    • Billen A, Madrigal JA, Strydom A, Szydlo RM, Switzer GE, Shaw BE (2015). Predonation health-related quality of life scores predict time to recovery in hematopoietic stem cell donors.. Biol Blood Marrow Transplant, 21(2), 350 - 356. doi:10.1016/j.bbmt.2014.10.028


    • Hassiotis A, Strydom A, King M, Crawford M, Hall I, Omar R, Vickerstaff V, Hunter R, Crabtree J, Cooper V, Biswas A, Howie W (2014). Clinical and cost effectiveness of staff training in Positive Behaviour Support (PBS) for treating challenging behaviour in adults with intellectual disability: A cluster randomised controlled trial. BMC Psychiatry, 14(1), - . doi:10.1186/s12888-014-0219-6
    • Glover G, Bernard S, Branford D, Holland A, Strydom A (2014). Use of medication for challenging behaviour in people with intellectual disability.. Br J Psychiatry, 205(1), 6 - 7. doi:10.1192/bjp.bp.113.141267
    • Zis P, McHugh P, McQuillin A, Praticò D, Dickinson M, Shende S, Walker Z, Strydom A (2014). Memory decline in Down syndrome and its relationship to iPF2alpha, a urinary marker of oxidative stress.. PLoS One, 9(6), e97709 - . doi:10.1371/journal.pone.0097709
    • Rai D, Hall W, Bebbington P, Skapinakis P, Hassiotis A, Weich S, Meltzer H, Moran P, Brugha T, Strydom A, Farrell M (2014). Estimated verbal IQ and the odds of problem gambling: a population-based study.. Psychol Med, 44(8), 1739 - 1749. doi:10.1017/S0033291713002195
    • Buszewicz M, Welch C, Horsfall L, Nazareth I, Hunter R, Osborn D, Hassiotis A, Hithersay R, Strydom A, Glover G, Chauhan U, Hoghton M, Cooper SA, Moulster G, Heslop P, Courtenay K (2014). Assessment of an incentivised scheme to provide annual health checks in primary care for adults with intellectual disability: A longitudinal cohort study. The Lancet Psychiatry, 1(7), 522 - 530. doi:10.1016/S2215-0366(14)00079-0
    • Thomas B, Courtenay K, Hassiotis A, Strydom A, Rantell K (2014). Standardised patients with intellectual disabilities in training tomorrow's doctors.. Psychiatr Bull (2014), 38(3), 132 - 136. doi:10.1192/pb.bp.113.043547
    • Sheehan R, Sinai A, Bass N, Blatchford P, Bohnen I, Bonell S, Courtenay K, Hassiotis A, Markar T, McCarthy J, Mukherji K, Naeem A, Paschos D, Perez-Achiaga N, Sharma V, Thomas D, Walker Z, Strydom A (2014). Dementia diagnostic criteria in Down syndrome.. Int J Geriatr Psychiatry, , - . doi:10.1002/gps.4228
    • Hithersay R, Strydom A, Moulster G, Buszewicz M (2014). Carer-led health interventions to monitor, promote and improve the health of adults with intellectual disabilities in the community: A systematic review. Research in Developmental Disabilities, 35(4), 887 - 907. doi:10.1016/j.ridd.2014.01.010
    • Strydom A, Giaroli G, Bass N (2014). Does rare matter? Copy Number Variants at 16p11.2 and the risk of psychosis: A systematic review of literature and metaanalysis.. Schizophrenia Research, , - .


    • Strydom A, Chan T, Fenton C, Jamieson-Craig R, Livingston G, Hassiotis A (2013). Validity of criteria for dementia in older people with intellectual disability.. Am J Geriatr Psychiatry, 21(3), 279 - 288. doi:10.1016/j.jagp.2012.11.017
    • Hassiotis A, Serfaty M, King M, Azam K, Martin S, Strydom A, Romeo R, Blizard R (2013). Manualised Individual Cognitive Behavioural Therapy for mood disorders in people with mild to moderate intellectual disability: A feasibility randomised controlled trial. Journal of Affective Disorders, 151(1), 186 - 195. doi:10.1016/j.jad.2013.05.076
    • Ali A, Scior K, Ratti V, Strydom A, King M, Hassiotis A (2013). Discrimination and Other Barriers to Accessing Health Care: Perspectives of Patients with Mild and Moderate Intellectual Disability and Their Carers. PLoS ONE, 8(8), e70855 - e70855. doi:10.1371/journal.pone.0070855
    • Strydom A, Chan T, King M, Hassiotis A, Livingston G (2013). Incidence of dementia in older adults with intellectual disabilities.. Res Dev Disabil, 34(6), 1881 - 1885. doi:10.1016/j.ridd.2013.02.021
    • Sinai A, Strydom A, Hassiotis A (2013). Evaluation of medical students' attitudes towards people with intellectual disabilities: A naturalistic study in one medical school. Advances in Mental Health and Intellectual Disabilities, 7(1), 18 - 26. doi:10.1108/20441281311294666
    • Ali A, Ambler G, Strydom A, Rai D, Cooper C, McManus S, Weich S, Meltzer H, Dein S, Hassiotis A (2013). The relationship between happiness and intelligent quotient: the contribution of socio-economic and clinical factors.. Psychol Med, 43(6), 1303 - 1312. doi:10.1017/S0033291712002139


    • Zis P, Dickinson M, Shende S, Walker Z, Strydom A (2012). Oxidative stress and memory decline in adults with Down syndrome: longitudinal study.. J Alzheimers Dis, 31(2), 277 - 283. doi:10.3233/JAD-2012-120073
    • Strydom A, Chan T, Fenton C, Craig R, Livingston G, Hassiotis A (2012). Validity of Criteria for Dementia in Older People With Intellectual Disability.. Am J Geriatr Psychiatry, , - . doi:10.1097/JGP.0b013e31824472be
    • Zis P, Dickinson M, Shende S, Walker Z, Strydom A (2012). Superoxide dismutase (SOD1) functioning as a predictor of memory decline in Down syndrome (DS).
    • Livingston G, Strydom A (2012). Improving Alzheimer's disease outcomes in Down's syndrome.. Lancet, 379(9815), 498 - 500. doi:10.1016/S0140-6736(11)61929-6
    • Kock E, Molteno C, Mfiki N, Kidd M, Ali A, King M, Strydom A (2012). Cross-Cultural Validation of a Measure of Felt Stigma in People with Intellectual Disabilities. JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES, 25(1), 11 - 19. doi:10.1111/j.1468-3148.2011.00644.x
    • Sinai A, Bohnen I, Strydom A (2012). Older adults with intellectual disability.. Curr Opin Psychiatry, 25(5), 359 - 364. doi:10.1097/YCO.0b013e328355ab26
    • Ali A, Hassiotis A, Strydom A, King M (2012). Self stigma in people with intellectual disabilities and courtesy stigma in family carers: a systematic review.. Res Dev Disabil, 33(6), 2122 - 2140. doi:10.1016/j.ridd.2012.06.013
    • Azam K, Serfaty M, King M, Martin S, Strydom A, Parkes C, Hassiotis A (2012). The development of manualised cognitive behaviour treatment for adults with mild intellectual disability and common mental disorders.. Psychiatriki, 23(2), 109 - 116.


    • Hassiotis A, Gazizova D, Akinlonu L, Bebbington P, Meltzer H, Strydom A (2011). Psychiatric morbidity in prisoners with intellectual disabilities: analysis of prison survey data for England and Wales.. Br J Psychiatry, 199(2), 156 - 157. doi:10.1192/bjp.bp.110.088039
    • Hassiotis A, Gazizova D, Akinlonu L, Rebbington P, Meltzer H, Strydom A (2011). Psychiatric morbidity in prisoners with intellectual disabilities reply. BRITISH JOURNAL OF PSYCHIATRY, 199(6), 514 - 514. doi:10.1192/bjp.199.6.514a
    • Hassiotis A, Serfaty M, Azam K, Strydom A, Martin S, Parkes C, Blizard R, King M (2011). Cognitive behaviour therapy (CBT) for anxiety and depression in adults with mild intellectual disabilities (ID): a pilot randomised controlled trial.. Trials, 12, 95 - . doi:10.1186/1745-6215-12-95
    • Iwata K, Strydom A, Osborn D (2011). Insight and other predictors of physical examination refusal in psychotic illness.. J Ment Health, 20(4), 319 - 327. doi:10.3109/09638237.2011.556158


    • Hillier B, Wright L, Strydom A, Hassiotis A (2010). Use of the HoNOS-LD in identifying domains of change. The Psychiatrist, 34, 322 - 326. doi:10.1192/pb.bp.108.024323
    • Strydom A, Romeo R, Perez-Achiaga N, Livingston G, King M, Knapp M, Hassiotis A (2010). Service use and cost of mental disorder in older adults with intellectual disability. British Journal of Psychiatry, 196, 133 - 138. doi:10.1192/bjp.bp.108.060939
    • Torr J, Strydom A, Patti P, Jokinen N (2010). Aging in Down Syndrome: Morbidity and Mortality. Journal of Policy and Practice in Intellectual Disabilities, 7(1), 70 - 81.
    • Haveman M, Heller T, Lee L, Maaskant M, Shooshtari S, Strydom A (2010). Major Health Risks in Aging Persons With Intellectual Disabilities: An Overview of Recent Studies. Journal of Policy and Practice in Intellectual Disabilities, 7(1), 59 - 69.
    • Courtenay K, Jokinen NS, Strydom A (2010). Caregiving and Adults With Intellectual Disabilities Affected by Dementia. Journal of Policy and Practice in Intellectual Disabilities, 7(1), 26 - 33.
    • Strydom A, Shooshtari S, Lee L, Raykar V, Torr J, Tsiouris J, Jokinen N, Courtenay K, Bass N, Sinnema M, Maaskant M (2010). Dementia in Older Adults With Intellectual Disabilities-Epidemiology, Presentation, and Diagnosis. Journal of Policy and Practice in Intellectual Disabilities, 7(2), 96 - 110.
    • Jamieson-Craig R, Scior K, Chan T, Fenton C, Strydom A (2010). Reliance on carer reports of early symptoms of dementia among adults with intellectual disabilities. Journal of Policy and Practice in Intellectual Disabilities, 7(1), 34 - 41.


    • Courtenay K, Soni S, Strydom A, Turk J (2009). Behavioural phenotypes and mental disorders. Psychiatry, 8(10), 391 - 397. doi:10.1016/j.mppsy.2009.06.020
    • Allison L, Strydom A (2009). Intellectual disability across cultures. Psychiatry, 8(9), 355 - 357. doi:10.1016/j.mppsy.2009.06.008
    • Strydom A, Hassiotis A, King M, Livingston G (2009). The relationship of dementia prevalence in older adults with intellectual disability (ID) to age and severity of ID. Psychological Medicine, 39, 13 - 21. doi:10.1017/S0033291708003334
    • Strydom A, Dickinson MJ, Shende S, Pratico D, Walker Z (2009). Oxidative stress and cognitive ability in adults with Down syndrome. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(1), 76 - 80. doi:10.1016/j.pnpbp.2008.10.006
    • Strydom A, Torr J (2009). Mental Health of Older People. In Hassiotis A, Andrea-Barron D, Hall I (Ed.), Intellectual disability Psychiatry: A Practical Handbook (pp. 149 - 168). : John Wiley & Sons, Ltd.


    • Hassiotis A, Strydom A, Hall I, Ali A, Lawrence-Smith G, Meltzer H, Head J, Bebbington P (2008). Psychiatric morbidity and social functioning among adults with borderline intelligence living in private households.. J Intellect Disabil Res, 52(Pt 2), 95 - 106. doi:10.1111/j.1365-2788.2007.01001.x
    • Ali AK, Strydom A, Hassiotis A, King M (2008). A measure of the perceived stigma of intellectual disability. British Journal of Psychiatry, 193, 410 - 415.
    • Andrea BD, Strydom , A , Hassiotis , A (2008). What to tell and how to tell: a qualitative study of information sharing in research for adults with intellectual disability. Journal of Medical Ethics, 34, 501 - 506.


    • Strydom A, Livingston G, King M, Hassiotis A (2007). Prevalence of dementia in intellectual disability using different diagnostic criteria.. Br J Psychiatry, 191, 150 - 157. doi:10.1192/bjp.bp.106.028845


    • Strydom A, Hassiotis A, Livingston G (2005). Mental health and social care needs of older people with intellectual disabilities. Journal of Applied Research in Intellectual Disabilities, 18(3), 229 - 235. doi:10.1111/j.1468-3148.2005.00221.x
    • Hall I, Strydom A, Richards M, Hardy R, Bernal J, Wadsworth M (2005). Social outcomes in adulthood of children with intellectual impairment: evidence from a birth cohort.. J Intellect Disabil Res, 49(Pt 3), 171 - 182. doi:10.1111/j.1365-2788.2005.00636.x


    • Strydom A, Higgins N (2004). Are dedicated research posts of value to psychiatry trainees?. Psychiatric Bulletin, 28(7), 260 - 263.
    • Strydom A, Hassiotis A, Walker Z (2004). Magnetic resonance imaging in people with Down's Syndrome and Alzheimer's disease. Journal of Intellectual Disability Research, 48(8), 769 - 770. doi:10.1111/j.1365-2788.2003.00571.x


    • Banham K, Garrett M, McClean A, Strydom A, Hassiotis A (2003). About leaving: making sense of moving on. British Journal of Learning Disabilities, 31, 70 - 73.
    • Hassiotis A, Strydom A, Allen K, Walker Z (2003). A memory clinic for older people with intellectual disabilities. Aging and Mental Health, 7(6), pp.418 - 423. doi:10.1080/13607860310001594664
    • Strydom A, Hassiotis A (2003). Diagnostic instruments for dementia in older people with intellectual disability in clinical practice. Aging and Mental Health, 7(6), 431 - 437. doi:10.1080/13607860310001594682
    • Strydom A (2003). Down's syndrome. The Lancet, 362(9377), 80 - 81. doi:10.1016/S0140-6736(03)13825-1


    • Strydom A (2002). Mental disorders predicted all cause and cause specific deaths in Finnish adults. Evidence-Based Mental Health, 5(3), 93 - .
    • Strydom A, Hassiotis A, Walker Z (2002). Clinical use of structural magnetic resonance imaging in the diagnosis of dementia in adults with Down's syndrome. Irish Journal of Psychological Medicine, 19(2), 60 - 63.


    • Richards M, Maughan B, Hardy R, Hall I, Strydom A, Wadsworth M (2001). Long-term affective disorder in people with mild learning disability.. Br J Psychiatry, 179, 523 - 527.
    • Strydom A, Forster M, Wilkie BM, Edwards C, Hall IS (2001). Patient information leaflets for people with learning disabilities who take psychiatric medication. British Journal of Learning Disabilities, 29(2), 72 - 76. doi:10.1046/j.1468-3156.2001.00108.x
    • Strydom A, Hall I (2001). Randomized trial of psychotropic medication information leaflets for people with intellectual disability.. J Intellect Disabil Res, 45(Pt 2), 146 - 151.