Dr Anastasis Stephanou

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Personal Profile

Name: Anastasis Stephanou Email: a.stephanou@ucl.ac.uk
Title: Dr Tel: 0207 905 2216
Department: ICH Genetics & Genomic Medicine Prog Fax:
Position: Reader in Molecular and Cell Biology Address: Medical Molecular Biology Unit, Institute of Child Health, UCL, 30 Guildford St, London, WC1N 1EH
Research Domain: Basic Life Sciences, Cancer, Cardiometabolic Science, Infection, Immunology & Inflammation, Personalised Medicine, Populations & Lifelong Health Web Page:  

Profile

Research Description

On going research of my group involve studies into the role of STAT1 and STAT3 in the heart exposed to I/R injury and to identify novel binding partners that may be important in modulating the activity of STAT1 or STAT1. I am also now investigating the impact of STAT1 and STAT3 in human cancer.

We have recently generating a C-terminal STAT1 knock out animal (Ozgene Ltd) to further characterise the role of STAT1 in vivo. These animal models will enable us to understand further the death pathways that are initiated during ischaemia/reperfusion injury and therefore ultimately lead to identification of therapeutic targets for the prevention of cell death in the ischaemic myocardium.

Our previous published studies have thus suggested STAT1 as a therapeutic target in attempt to protect against cell death / damage in the myocardium following I/R injury. The recent report that epigallocatechin-3-gallate (EGCG, a polyphenolic agent and major constituent of green tea) is a potent inhibitor of STAT1 in non cardiac cells led us to demonstrate that EGCG is also able to protect the isolated intact heart ex-vivo exposed to I/R injury. We will also like to analyse target genes that are modulated by EGCG by DNA gene chip array and a proteomic approach.

Other continuing research in the cancer field include our recent published work showing that STAT1 enhances the functional activity of p53 in non cardiac cells and examining this role further in double knock-out mice lacking STAT1 and p53. The p53/STAT1 double knock-out mice are more susceptible for tumour formation and at a much earlier frequency than the p53 deficient mice (unpublished data). A recent grant funded by the Leukemia Research Fund with Dr P. Townsend (University of |Southampton) will investigate further the mechanism of how p53 and p73 (a related family member of p53) are able to collaborate in their tumour suppressor function. We have also started to assess the role of STAT1 and STAT3 in the cell cycle checkpoint pathways following DNA damage. Studies are underway to identity novel interacting protein partners for STAT1 or STAT3 that may explain their opposing actions in cell death pathways or the cell cycle regulation. Using an antibody protein array approach we have data that STAT1 is able to interact with several important cell cycle regulators and may suggest that STAT1 may have roles that are independent of its known role as a transcriptional regulator.

Research Activities

Bio-electrospraying: a novel approach for tissue engineering and tissue regeneration

Examine the relationship between constitutive ERK activity and STAT1 levels in leukaemia

Examine the role of IL-17 in the ischaemic myocardium

Interaction of p73 with STAT1

Opposing roles of STAT1 and STAT3 in Disease

STAT1 and STAT3 inhibitory peptides as therapeutic agents in the isolated heart

The role of STAT1 and STAT3 in models of stroke

The role of STAT1 and STAT3 in the cell cycle checkpoint response to DNA damage

Education Description

MSc teaching on the Biomaterial and tissue engineering module in the Department of Mechanical Engineering, UCL.

Also supervision of numerous PhD students within our department (primary and secondary supervisor). Also External examiner for Board meetings at the University of Westminster for the MSc courses in Biomedical Sciences. Have also been both an Internal and External Examiner for numerous PhD oral examinations

UCL Collaborators

Dr Mike Hubank; Prof Mark Lythgoe; Prof David Gadian

External Collaborators

Professor Yoichiro Iwakura; Professor Graham Packham; Dr Vincenzo De Laurenzi ; Dr Paul Townsend; Professor Gerry Melino; Dr Tiziano Scarabelli

Publications

    2014

    • Chen-Scarabelli C, Knight R, Stephanou A, Scarabelli G, Onorati F, Tessari M, Rungatscher A, Narula J, Saravolatz L, Mazzucco A, Faggian G, Scarabelli TM (2014). Diabetic hearts have lower basal urocortin levels that fail to increase after cardioplegic arrest: Association with increased apoptosis and postsurgical cardiac dysfunction.. J Thorac Cardiovasc Surg, , - . doi:10.1016/j.jtcvs.2014.05.018

    2013

    • Bourke LT, Knight RA, Latchman DS, Stephanou A, McCormick J (2013). Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy.. JAKSTAT, 2(4), e25666 - . doi:10.4161/jkst.25666
    • Bourke L, McCormick J, Ripoll V, Pericleous C, Radziszewska A, Stephanou A, Ioannou Y (2013). Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury.
    • Georgiadis V, Knight RA, Jayasinghe SN, Stephanou A (2013). Cardiac tissue engineering: renewing the arsenal for the battle against heart disease.. Integr Biol (Camb), , - . doi:10.1039/c3ib40097b
    • Barry SP, Ounzain S, McCormick J, Scarabelli TM, Chen-Scarabelli C, Saravolatz LI, Faggian G, Mazzucco A, Suzuki H, Thiemermann C, Knight RA, Latchman DS, Stephanou A (2013). Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury.. Int J Cardiol, 163(3), 326 - 334. doi:10.1016/j.ijcard.2011.08.849
    • Chen-Scarabelli C, Saravolatz Ii L, McCaukey R, Scarabelli G, Di Rezze J, Mohanty B, Barry S, Latchman D, Georgiadis V, McCormick J, Saravolatz L, Knight R, Faggian G, Narula J, Stephanou A, Scarabelli TM (2013). The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway.. JAKSTAT, 2(3), e24812 - . doi:10.4161/jkst.24812
    • Onorati F, Chen-Scarabelli C, Knight R, Stephanou A, Mohanti B, Santini F, Tessari M, Kini A, Narula J, Saravolatz L, Mazzucco A, Scarabelli T, Faggian G (2013). Targeting Urocortin Signaling Pathways to Enhance Cardioprotection: Is It Time to Move from Bench to Bedside?. Cardiovasc Drugs Ther, , - . doi:10.1007/s10557-013-6468-7
    • Carroll CJ, Sayan BS, Bailey SG, McCormick J, Stephanou A, Latchman DS, Townsend PA (2013). Regulation of myocardial interleukin-6 expression by p53 and STAT1.. J Interferon Cytokine Res, 33(9), 542 - 548. doi:10.1089/jir.2012.0165
    • Bourke L, McCormick J, Stephanou A, Ioannou Y (2013). Hydroxycholorquine Is Cardioprotective In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury.-An Effect Mediated Through ERK Phosphorylation..

    2012

    • Knight RA, Scarabelli TM, Stephanou A (2012). STAT transcription in the ischemic heart.. JAKSTAT, 1(2), 111 - 117. doi:10.4161/jkst.20078
    • Klionsky DJ, Backues SK, Bartholomew CR, Bridges D, Gestwicki JE, Han T, Jin M, Kim JK, Lin JD, Lynch-Day MA, Mao K, Nair U, Parzych KR, Umekawa M, Wang K, Yen W-L, Zhao M, Olsen LJ, Abdalla FC, Marcondes M, Silva-Zacarin ECM, Silva-Zacarin E, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Chiarelli R, Roccheri MC, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Saitoh T, Al-Younes HM, Al-Zeer MA, Meyer TF, Albert ML, Albin RL, Dowling JJ, Alegre-Abarrategui J, Wade-Martins R, Aleo MF, Fanzani A, Rovetta F, Alirezaei M, Chisari FV, Whitton JL, Almasan A, Almonte-Becerril M, Kouri Flores JB, Amano A, Amaravadi R, Amarnath S, Fowler DH, Amer AO, Drew ME, Andrieu-Abadie N, Poirot M, Vindis C, Anantharam V, Kanthasamy AG, Kanthasamy A, Ann DK, Anoopkumar-Dukie S, Grant GD, Aoki H, Apostolova N, Arancia G, Condello M, Meschini S, Aris JP, Asanuma K, Tomino Y, Asare NYO, Ashida H, Askanas V, Nogalska A, Askew DS, Auberger P, Bost F, Gual P, Luciano F, Rocchi S, Baba M, Baehrecke EH, Bahr BA, Bai X-Y, Chen X, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Brunetti-Pierri N, Settembre C, Bamber BA, Bampton ETW, Melino G, Bánhegyi G, Bassham DC, Bast Jr RC, Fan Z, Lopez-Berestein G, Lu Z, Ozpolat B, Batoko H, Bay B-H, Beau I, Esclatine A, Béchet DM, Begley TJ, Behl C, Behrends C, Dikic I, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Sanchez AMJ, Bernassola F, Marfe G, Palumbo C, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Espert L, Blum JS, Boise LH, Lonial S, Sun S-Y, Bonaldo P, Sandri M, Boone DL, Bornhauser BC, Bourquin J-P, Bortoluci KR, Bossis I, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Nezis IP, Rusten TE, Stenmark H, Brenman JE, Brennand A, Michels PAM, Bresnick EH, Kang Y-A, Brest P, Hofman P, Mograbi B, Bristol ML, Gewirtz DA, Brookes PS, Johnson GVW, Brown EJ, Brumell JH, Huang J, Kim PK, Brunk UT, Kurz T, Bulman DE, Bultman SJ, Bultynck G, Parys JB, Burbulla LF, Krüger R, Bursch W, Butchar JP, Buzgariu W, Galliot B, Bydlowski SP, Cadwell K, Cahová M, Papackova Z, Cai D, Cai J, Cai Q, Calabretta B, Sotgia F, Calvo-Garrido J, Escalante R, Camougrand N, Manon S, Priault M, Campanella M, Campos-Salinas J, Gonzalez-Rey E, Oliver FJ, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Moreira PI, Carew JS, Nawrocki ST, Carlin CR, Carmignac V, Durbeej M, Carneiro LAM, Carra S, Kampinga HH, Caruso RA, Casari G, Casas C, Castino R, Isidoro C, Cebollero E, Reggiori F, Cecconi F, Ciriolo MR, Piacentini M, Celli J, Chaachouay H, Rodemann HP, Chae H-J, Chai C-Y, Chan DC, Chan EY, Coombs GH, Chang RC-C, Che C-M, Lok C-N, Sy L-K, Chen C-C, Lin W-W, Chen G-C, Yang WY, Chen G-Q, Chen M, Wang J, Chen Q, Chen SS-L, Ke P-Y, Lin Y-L, Chen W, Chen Y-G, Liu Y, Yu L, Chen Y, Guan J-L, Towns R, Wiley JW, Chen Y-J, Chen Z, Cheng A, Cheng CHK, Cheng Y, Wang H-G, Yang J-M, El-Deiry WS, Cheong H, Thompson CB, Cheong J-H, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang H-L, Chiba T, Chin L-S, Li L, Mao Z, Chiou S-H, Cho CH, Cho D-H, Choi AMK, Haspel JA, Henske EP, Nakahira K, Ryter SW, Choi D, Choi KS, Choi ME, Münger K, Chouaib S, Choubey D, Choubey V, Kaasik A, Chu CT, Rabinowich H, Chuang T-H, Chueh S-H, Chun T, Park OK, Chwae Y-J, Chye M-L, Ciarcia R, Florio S, Granato GE, Clague MJ, Clark RSB, Clarke PGH, Puyal J, Clarke R, Saha T, Codogno P, Coller HA, Colombo MI, Comincini S, Condorelli F, Cookson MR, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Helfrich MH, Hocking LJ, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Kaushik S, Koga H, Czaja MJ, Cullen JJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, De Groot JF, Fueyo J, Gomez-Manzano C, Jiang H, De Haan CAM, Monastyrska I, De M (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445 - 544. doi:10.4161/auto.19496
    • McCormick J, Suleman N, Scarabelli TM, Knight RA, Latchman DS, Stephanou A (2012). STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy.. J Cell Mol Med, 16(2), 386 - 393. doi:10.1111/j.1582-4934.2011.01323.x
    • McCormick J, Knight RA, Barry SP, Scarabelli TM, Abounit K, Latchman DS, Stephanou A (2012). Autophagy in the stress-induced myocardium.. Front Biosci (Elite Ed), 4, 2131 - 2141.
    • Stephanou A (2012). The beginning of the STAT: Letter from the Editor.. JAKSTAT, 1(1), 1 - . doi:10.4161/jkst.18708

    2011

    • Berry S, Stephanou A, Faggian G, Mazzucco A, II SL, Waqas Q, Shieh W-S, Scarabelli G, Saravolatz L, Chen-Scarabelli C, Scarabelli TM (2011). Postischemic Induction of IL-17 Signaling Promotes Necrotic and Apoptotic Cell Death in the Rat Heart Exposed to in Vivo Ischemia/Reperfusion Injury. CIRCULATION, 124(21), - .
    • Ulgen BO, Field MG, Qureshi W, Knight RA, Stephanou A, Latchman DS, Vasquez D, Barry SP, Saravolatz L, Scarabelli GM, Faggian G, Mazzucco A, Saravolatz L, Chen-Scarabelli C, Scarabelli TM (2011). The role of minocycline in ischemia-reperfusion injury: a comprehensive review of an old drug with new implications.. Recent Pat Cardiovasc Drug Discov, 6(2), 123 - 132.
    • Carroll CJ, Suleman N, Davidson SM, Faulkes DJ, Diss JK, Knight R, Stephanou A, Latchman DS, Townsend PA (2011). Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury.. Int J Biochem Cell Biol, 43(1), 74 - 79. doi:10.1016/j.biocel.2010.09.020
    • Stephanou A, Latchman DS (2011). Transcriptional modulation of heat-shock protein gene expression.. Biochem Res Int, 2011, 238601 - . doi:10.1155/2011/238601
    • Ng KE, Joly P, Jayasinghe SN, Vernay B, Knight R, Barry SP, McComick J, Latchman D, Stephanou A (2011). Bio-electrospraying primary cardiac cells: in vitro tissue creation and functional study.. Biotechnol J, 6(1), 86 - 95. doi:10.1002/biot.201000125
    • Carroll CJ, Suleman N, Davidson SM, Faulkes DJ, Diss JK, Knight R, Stephanou A, Latchman DS, Townsend PA (2011). Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury. INT J BIOCHEM CELL B, 43(1), 74 - 79. doi:10.1016/j.bioce1.2010.09.020

    2010

    • Barry SP, Lawrence KM, McCormick J, Soond SM, Hubank M, Eaton S, Sivarajah A, Scarabelli TM, Knight RA, Thiemermann C, Latchman DS, Townsend PA, Stephanou A (2010). New targets of urocortin-mediated cardioprotection.. J Mol Endocrinol, 45(2), 69 - 85. doi:10.1677/JME-09-0148
    • Dimco G, Knight RA, Latchman DS, Stephanou A (2010). STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest.. Cell Cycle, 9(23), 4638 - 4649.
    • Yuan Z, McCauley R, Chen-Scarabelli C, Abounit K, Stephanou A, Barry SP, Knight R, Saravolatz SF, Saravolatz LD, Ulgen BO, Scarabelli GM, Faggian G, Mazzucco A, Saravolatz L, Scarabelli TM (2010). Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection.. Mol Cell Endocrinol, 325(1-2), 1 - 7. doi:10.1016/j.mce.2010.04.013
    • Bailey SG, Sanchez-Elsner T, Stephanou A, Cragg MS, Townsend PA (2010). Regulating the genome surveillance system: miRNAs and the p53 super family.. Apoptosis, 5, 541 - 552.
    • Barry SPTPAKRASTMLDSSA (2010). STAT3 modulates the DNA damage response pathway.. Int J Exp Pathol, , - .

    2009

    • Stephanou A, Knight RAL, D S (2009). STAT1 and STAT3: Opposing roles in Cell Death and Cell Cycle Regulation. JAK-STAT Pathway in Disease.
    • Ripley B, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight R, Isenberg D, Latchman D, Kishimoto T, Naka T (2009). Green tea regulates cell signalling by inducing SOCS1 gene expression via its constituent polyphenol EGCG. doi:10.1016/j.cyto.2009.07.383
    • Stephanou A (2009). JAK-STAT pathway in disease.
    • Scarabelli TM, Mariotto S, bdel-Azeim S, Shoji K, Darra E, Stephanou A, Chen-Scarabelli C, Marechal JD, Knight R, Ciampa A, Saravolatz L, de Prati AC, Yuan Z, Cavalieri E, Menegazzi M, Latchman D, Pizza C, Perahia D, Suzuki H (2009). Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury. FEBS Letters, 583(3), 531 - 541.
    • Barry SP, Townsend PA, McCormick J, Knight RA, Scarabelli TM, Latchman DS, Stephanou A (2009). STAT3 deletion sensitizes cells to oxidative stress. Biochemical and Biophysical Research Communications, 385(3), 324 - 329.
    • Rybka AE, Stephanou A, Townsend PA (2009). Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) Pathway in Heart Disease. In Stephanou A (Ed.), (pp. 76 - 85). : Landes Biosciences.

    2008

    • Knight RA, Chen-Scarabelli C, Yuan Z, McCauley RB, Rezze JD, Scarabelli GM, Townsend PA, Latchman D, Saravolatz L, Faggian G, Mazzucco A, Chowdrey HS, Stephanou A, Scarabelli TM (2008). Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury. FEBS Lett., , - .
    • Barry SP, Jayasinghe SN, Pericleous C, Hubank M, Latchman DS, Stephanou A (2008). Gene expression studies on bio-electrosprayed primary cardiac myocytes. Biotechnology Journal, 3, 530 - 535.
    • Soond SM, Townsend PA, Barry SP, Knight RA, Latchman DS, Stephanou A (2008). ERK and the F-box protein beta TRCP target STAT1 for degradation. Journal of Biological Chemistry, 283(23), 16077 - 16083.
    • Scarabelli TM, Townsend PA, Chen-Scarabelli C, Yuan Z, McCauley RB, Di Rezze J, Patel D, Putt J, Allebban Z, Abboud J, Chilukuri K, Gardin J, Saravolatz L, Knight RA, Latchman DS, Stephanou A (2008). Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury. The American Journal of Cardiology, 101(11A), 63E - 68E.
    • Soond SM, Barry S, Melino G, Knight RA, Latchman DS, Stephanou A (2008). p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1. Cell Cycle, 7(9), 1214 - 1223.

    2007

    • Barry SP, Townsend PA, Latchman DS, Stephanou A (2007). Role of the JAK-STAT pathway in myocardial injury. Trends in Molecular Medicine, 13(2), 82 - 89.
    • Townsend PA, Davidson SM, Clarke SJ, Khaliulin I, Carroll CJ, Scarabelli TM, Knight RA, Stephanou A, Latchman DS, Halestrap AP (2007). Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress. American Journal of Physiology.Heart and Circulatory Physiology, 293(2), H928 - H938.
    • Barry SP, Jayasinghe SN, Latchman DS, Stephanou A (2007). Bio-electrospraying primary neonatal cardiac myocytes. BioProcessing Journal, 6, 8 - 14.
    • Soond SM, Carroll C, Townsend PA, Sayan E, Melino G, Behrmann I, Knight RA, Latchman DS, Stephanou A (2007). STAT1 regulates p73-mediated Bax gene expression. FEBS Lett, 581(6), 1217 - 1226.
    • Francis YI, Diss JKJ, Kariti M, Stephanou A, Latchman DS (2007). p300 Activation by Presenilin 1 but not by its M146L mutant. Neuroscience Letters, 413(2), 137 - 140.

    2006

    • McCormick J, Barry SP, Sivarajah A, Stefanutti G, Townsend PA, Lawrence KM, Eaton S, Knight RA, Thiemermann C, Latchman DS, Stephanou A (2006). Free radical scavening inhibits STAT phosphorylation following in vivo ischaemia/reperfusion injury. The FASEB Journal, 20(12), 2115 - 2117. doi:10.1096/fj.06-6188fje
    • Valentim L, Lawrence KM, Townsend PA, Carroll CJ, Soond S, Scarabelli TM, Knight RA, Latchman DS, Stephanou A (2006). Urocortin inhibits Beclin 1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/ reperfusion injury. Journal of Molecular and Cellular Cardiology, 40, 846 - 852.
    • Francis YI, Diss JK, Kariti M, Stephanou A, Latchman DS (2006). p300 activation by Presenilin 1 but not by its M146L mutant. Neurosci Lett, , - .
    • Soond SM, Latchman DS, Stephanou A (2006). STAT signalling in the heart and cardioprotection. Expert Reviews in Molecular Medicine, 8, 1 - 16.
    • Scarabelli TM, Knight R, Stephanou A, Townsend P, Chen-Scarabelli C, Lawrence K, Gottlieb R, Latchman D, Narula J (2006). Clinical implications of apoptosis in ischemic myocardium. Current Problems in Cardiology, 31(3), 181 - 264.
    • Francis YI, Stephanou A, Latchman DS (2006). CREB-binding protein activation by presenilin 1 but not by its M146L mutant. NeuroReport, 17, 917 - 921.

    2005

    • Stephanou A, Latchman DS (2005). Opposing actions of STAT-1 and STAT-3. Growth Factors, 23(3), 177 - 182.
    • Chanalaris A, Lawrence KM, Townsend PA, Davidson S, Jamshidi Y, Stephanou A, Knight RD, Hsu SY, Hsueh AJW, Latchman DS (2005). Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway (vol 328, pg 442, 2005). BIOCHEM BIOPH RES CO, 330(1), 356 - 356. doi:10.1016/j.bbrc.2005.02.124
    • Lawrence KM, Kabir AM, Bellahcene M, Davidson S, Cao XB, McCormick J, Mesquita RA, Carroll CJ, Chanalaris A, Townsend PA, Hubank M, Stephanou A, Knight RA, Marber MS, Latchman DS (2005). Cardioprotection mediated by urocortin is dependent on PKCepsilon activation.. The FASEB Journal, 19(7), 831 - 833.
    • Stephanou A, Latchamn DS (2005). Molecular Chaparone-cytokine interaction at the Transcriptional Level. In Henderson B, Pockley GA (Ed.), Molecular Chaparones and Cell Siganalling (pp. 179 - 191). : Cambridge University Press.
    • Davidson SM, Townsend PA, Carroll C, Yurek-George A, Balasubramanyam K, Kundu TK, Stephanou A, Packham G, Ganesan A, Latchman DS (2005). The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. Chembiochem., 6(1), 162 - 170.
    • Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A (2005). STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. Journal of Cell Science, 118(8), 1629 - 1639. doi:10.1242/jcs.01728
    • Townsend PA, Stephanou A, Packham G, Latchman DS (2005). BAG-1: a multifunctional pro-survival molecule. The International Journal of Biochemistry and Cell Biology, 37, 251 - 259.
    • Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A (2005). STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J CELL SCI, 118(8), 1629 - 1639. doi:10.1242/jcs.01726
    • Chanalaris A, Lawrence KM, Townsend PA, Davidson S, Jamshidi Y, Stephanou A, Knight RD, Hsu SY, Hsueh AJW, Latchman DS (2005). Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochemical and Biophysical Research Communications, 328(2), 442 - 448.

    2004

    • Parkinson EJ, Townsend PA, Stephanou A, Latchman DS, Eaton S, Pierro A (2004). The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation. Journal of Pediatric Surgery, 39(5), 696 - 701.
    • Stephanou A, Chen-Scarabelli C, Latchman D, Gardin J, Narula J, Scarabelli T (2004). Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.
    • Townsend PA, Scarabelli TM, Pasini E, Gitti G, Menegazzi M, Suzuki H, Knight RA, Latchman DS, Stephanou A (2004). Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.. The FASEB Journal, 18(13), 1621 - 1623. doi:10.1096/fj.04-1716fje
    • West DA, Valentim LM, Lythgoe MF, Stephanou A, Proctor E, van der Weerd L, Ordidge RJ, Latchman DS, Gadian DA (2004). MR Image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischaemia. Neuroscience, 127, 333 - 339.
    • Munarriz E, Barcaroli D, Stephanou A, Townsend PA, Maisse C, Terrinoni A, Neale MH, Martin SJ, Latchman DS, Knight RA, Melino G, De Laurenzi V (2004). PIAS-1 is a checkpoint regulator which affects exit from G(1) and G(2) by sumoylation of p73. Molecular and Cellular Biology, 24(24), 10593 - 10610.
    • Scarabelli TM, Stephanou A, Pasini E, Gitti G, Townsend P, Lawrence K, Chen-Scarabelli C, Saravolatz L, Latchman D, Knight R, Gardin J (2004). Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. Journal of the American College of Cardiology, 43, 865 - 874.
    • Latchman DS, Stephanou A (2004). STAT-1 and STAT-3: closely-related transcription factors with antagonistic effects on cell proliferation and apoptosis. Current Genomics, 5, 453 - 457.
    • Stephanou A (2004). Role of STAT-1 and STAT-3 in ischaemia/reperfusion injury. J CELL MOL MED, 8(4), 519 - 525.
    • Townsend PA, Scarabelli TM, Davidson SM, Knight RA, Latchman DS, Stephanou A (2004). STAT-1 interacts with p53 to enhance DNA-damage induced apoptosis. Journal of Biological Chemistry, 279, 5811 - 5820.
    • Townsend PA, Cutress RI, Carroll CJ, Lawrence KM, Scarabelli TM, Packham G, Stephanou A, Latchman DS (2004). Bag-1 proteins protect cardiac myocytes from simulated ischaemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome. Journal of Biological Chemistry, 279, 20723 - 20728.
    • (2004). Epigallocatechin-3-gallate Inhibits STAT-1 Activation and Protects the myocardium from Ischemia/Reperfusion–Induced Apoptosis.. The FASEB Journal, 18(13), 1621 - 1623.
    • Scarabelli TM, Pasini E, Ferrari G, Ferrari M, Stephanou A, Lawrence K, Townsend P, Chen-Scarabelli C, Gitti G, Saravolatz L, Latchman D, Knight RA, Gardin JM (2004). Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells. The Journal of Thoracic and Cardiovascular Surgery, 128(3), 364 - 371.
    • Scarabelli TM, Pasini E, Stephanou A, Chen-Scarabelli C, Saravolatz L, Knight RA, Latchman DS, Gardin JM (2004). Nutritional supplementation with mixed essential amino acids enhances myocyte survival, preserving mitochondrial functional capacity during ischaemia/reperfusion injury. The American Journal of Cardiology, 93, 35A - 40A.
    • Stephanou A, Latchman DS (2004). Molecular chaperone/cytokine interactions at the transcriptional level. In Henderson B, Pockley AG (Ed.), The extracellular biology of molecular chaperones (pp. - ). : Cambridge University Press.
    • Davidson SM, Townsend PA, Carroll C, Yurek-George A, Balasubramanyam K, Kundu TK, Stephanou A, Packham G, Ganesan A, Latchman DS (2004). The Transcriptional Coactivator p300 Plays a Critical Role in the Hypertrophic and Protective Pathways Induced by Phenylephrine in Cardiac Cells but Is Specific to the Hypertrophic Effect of Urocortin. CHEMBIOCHEM, , - .
    • Lawrence KM, Townsend PA, Davidson SM, Carroll CJ, Eaton S, Hubank M, Knight RA, Stephanou A, Latchman DS (2004). The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage. Biochemical and Biophysical Research Communications, 321(2), 479 - 486.

    2003

    • Lawrence KM, Scarabelli TM, Turtle T, Chanalaris A, Townsend PA, Carroll CJ, Hubank M, Stephanou A, Knight RA, Latchman DS (2003). Urocortin protects cardiac myocytes from ischaemia/reperfusion injury by attenuating calcium insensitive phospholipase A2 gene expression. The FASEB Journal, 17, 2313 - 2315.
    • Scarabelli TM, Stephanou A, Raddino R, Townsend P, Lawrence K, Gitti G, Nordstrom C, Chen-Scarabelli C, Gardin J (2003). Minocycline, a novel cardioprotective agent, inhibits caspase activation and reactivation by increasing the ratio of XIAP to Smac/DIABLO and reducing mitochondrial leakage of cytochrome C and Smac/DIABLO.
    • Scarabelli TM, Pasini E, Ferrari G, Ferrari M, Stephanou A, Townsend P, Lawrence K, Chen-Scarabelli C, Knight R, Latchman D (2003). Warm blood cardioplegia induces mitochondria-initiated myocyte apoptosis which is ameliorated by overexpression of endogenous urocortin.
    • Chanalaris A, Latchman DS, Stephanou A (2003). Protective effects of the urocortin homologues Stresscopin (SCP) and Stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. Journal of Molecular and Cellular Cardiology, 35, 1295 - 1305.
    • Chanalaris A, Sun Y, Latchman DS, Stephanou A (2003). SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes.. J Mol Cell Cardiol, 35(3), 257 - 264.
    • Townsend P, Scarabelli TM, Lawrence K, Stephanou A, Carroll C, Chen-Scarabelli C, Cutress R, Peckham G, Latchman D (2003). Bag-1 relocates within cardiac myocytes following ischemia/reperfusion and prevents myocyte apoptosis by interaction with.
    • Stephanou A, Scarabelli TM, Lawrence K, Townsend P, Chen-Scarabelli C, Knight R, Latchman D (2003). Green tea inhibits Stat-1 activation and reduces apoptosis in cardiac myocytes exposed to ischemia/reperfusion injury.
    • Stephanou A, Latchman DS (2003). STAT-1: a novel regulator of apoptosis.. Int J Exp Pathol, 84(6), 239 - 244.
    • Davidson S, Stephanou A, Latchman D (2003). FLIP protects cardiomyocytes from apoptosis induced by simulated ischaemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA. Journal of Molecular and Cellular Cardiology, 35, 1359 - 1364.

    2002

    • (2002). Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischaemia/reperfusion injury. Cardiovascular Research, 53(4), 902 - 910.
    • Stephanou A (2002). Activated STAT-1 pathway in the myocardium as a novel therapeutic target in ischaemia/reperfusion injury.. Eur Cytokine Netw, 13(4), 401 - 403.
    • Stephanou A, Scarabelli TM, Townsend PA, Bell R, Yellon D, Knight RA, Latchman DS (2002). The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes. The FASEB Journal, 16(13), 1841 - 1843.
    • (2002). Anti-apoptotic activity of the free CARD domain of caspase-9: A novel endogenous rescue pathway. Journal of Biological Chemistry, 277(16), 13693 - 13699.
    • Stephanou A (2002). Activated STAT1 pathway in the myocardium as a novel therapeutic target in ischaemia/reperfusion injury. European Cytokine Network, 13, 387 - 390.
    • Scarabelli TM, Stephanou A, Pasini E, Comini L, Raddino R, Knight RA, Latchman DS (2002). Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Circulation Research, 90(6), 745 - 748. doi:10.1161/01.RES.0000015224.07870.9A
    • Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R, Tinker A, Stephanou A, Knight RA, Latchman DS (2002). K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect. Circulation, 106(12), 1556 - 1562. doi:10.1161/01.CIR.0000028424.02525.AE
    • Liao Z, Brar BK, Cai Q, Stephanou A, O'Leary RM, Pennica D, Yellon DM, Latchman DS (2002). Cardiotrophin-1 (CT-1) can protect the adult heart from injury when added both prior to ischaemia and at reperfusion. Cardiovascular Research, 53(4), 902 - 910.
    • (2002). Urocortin promotes hemodynamic and bioenergetic recovery and improves cell survival in the isolated rat heart exposed to ischemia/reperfusion. Journal of the American College of Cardiology, 40(1), 155 - 161.
    • (2002). Antiapoptotic activity of the free caspase recruitment domain of procaspase-9: a novel endogenous rescue pathway in cell death. Journal of Biological Chemistry, 277(16), 13693 - 13699.
    • (2002). Myocardial apoptosis following short periods of ischemia in the isolated rat heart: A hypothetical cut off point for experimental simulated angina?. Journal of the American College of Cardiology, 39(5), 325A - 325A.
    • (2002). Urocortin increases the expression of heat shock protein 90 in rat cardiac myocytes in a MEK1/2-dependent manner. Journal of Endocrinology, 172(2), 283 - 293.
    • (2002). Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. Journal of Molecular and Cellular Cardiology, 34(4), 483 - 492.
    • (2002). The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis. Cell Death and Differentiation, 9(10), 1140 - 1146.
    • Chen-Scarabelli CA, Scarabelli TM, Jamshidi Y, Hawe E, Stephanou A, Townsend P, Knight R, Latchman D (2002). Diagnostic value of CK-MB versus cardiac troponin I in the detection of myocardial injury after cardiac surgery.
    • Lawrence K, Chanalaris A, Scarabelli TM, Hubank M, Stephanou A, Knight R, Latchman D (2002). KATP channel gene expression is induced by urocortin and mediates its cardioprotective effect.
    • (2002). Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. Cytokine, 17(5), 243 - 253.

    2001

    • (2001). Distinct signaling pathways account for endothelial and myocardial apoptosis during ischaemia-reperfusion injury. Journal of the American College of Cardiology, 37(2), 309 - 309.
    • (2001). Distinct initiator caspases are required for the induction of apoptosis in cardiac myocytes during ischaemia versus reperfusion injury. Cell Death and Differentiation, 8(4), 234 - 235.
    • (2001). Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. Journal of Biological Chemistry, 276(30), 28340 - 28347.
    • (2001). CT-1 mediated cardioprotection against ischemic reoxygeneration injury is mediated by PI3-kinase,Akt and MEK1/2 pathways. Cytokine, 16, 93 - 96.
    • Scarabelli T, Scarabelli CC, Pasini E, Comini L, Curello S, Ferrari R, Knight R, Stephanou A, Latchman D (2001). Endothelial and myocardial apoptosis follow different signaling Pathways during ischaemia-reperfusion injury. EUR HEART J, 22, 371 - 371.
    • Scarabelli T, Stephanou A, Scarabelli CC, Pasini E, Comini L, Curello S, Ferrari R, Knight R, Latchman D (2001). Caspase activation independent from DNA fragmentation after brief periods of ischaemia: an hypothetical cut off point for simulated angina?. EUR HEART J, 22, 371 - 371.
    • Brar BK, Stephanou A, Liao Z, O'Leary RM, Pennica D, Yellon DM, Latchman DS (2001). Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation. Cardiovascular Research, 51(2), 265 - 274.
    • (2001). Relative contribution of the mitochondria and death receptor signalling pathways in cardiac apoptosis during ischaemia versus reperfusion injury. Circulation, 104(17), 936 - .
    • (2001). Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischaemia/reperfusion injury. Circulation, 104, 253 - 256.
    • Stephanou A, Scarabelli TM, Sarasso ML, Raddino R, Chen-Scarabelli C, Knight RA, Latchman DS (2001). Relative contribution of the mitochondria and death receptor signaling pathways in cardiac apoptosis during ischaemia versus reperfusion injury. CIRCULATION, 104(17), 195 - 196.
    • Scarabelli TM, Stephanou A, Chen CA, Cooper TJ, Knight RA, Latchman DS (2001). Distinct signaling pathways account for endothelial and myocardial apoptosis during ischaemia-reperfusion injury. J AM COLL CARDIOL, 37(2), 309S - 309S.
    • Stephanou A, Brar B, Liao Z, Scarabelli T, Knight RA, Latchman DS (2001). Distinct initiator caspases are required for the induction of apoptosis in cardiac myocytes during ischaemia versus reperfusion injury.. Cell Death Differ, 8(4), 434 - 435. doi:10.1038/sj.cdd.4400846

    2000

    • Scarabelli TM, Stephanou A, Brar BK, Rayment NB, Cooper TJ, Knight RA, Latchman DS (2000). Processing of procaspase 9 and 3 during ischaemic injury to cardiac myocytes. EUR HEART J, 21, 475 - 475.
    • Railson J, Lawrence K, Stephanou A, Brar B, Pennica D, Latchman D (2000). Cardiotrophin-1 reduces stress-induced heat shock protein production in cardiac myocytes. Cytokine, 12(11), 1741 - 1744.
    • Scarabelli TM, Stephanou A, Brar BK, Rayment NB, Cooper TJ, Knight RA, Latchman DS (2000). Processing of procaspase 9 and 3 during ischaemic injury to cardiac myocytes. European Heart Journal, 21, 2557 - .
    • Stephanou A, Brar BK, Scarabelli TM, Jonassen AK, Yellon DM, Marber MS, Knight RA, Latchman DS (2000). Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis. Journal of Biological Chemistry, 275(14), 10002 - 10008.
    • Stephanou A, Brar BK, Sacks MN, Latchman DS, Yellon DM (2000). Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters. Cell Death and Differentiation, 7, 329 - 330.
    • Brar BK, Jonassen AK, Stephanou A, Santilli G, Railson J, Knight RA, Yellon DM, Latchman DS (2000). Urocortin protects against ischemic and reperfusion injury via a MAPK- dependent pathway. Journal of Biological Chemistry, 275(12), 8508 - 8514.

    1999

    • Brar BS, Stephanou A, Wagstaff MJD, Coffin RS, Marber MS, Engelman G, Latchman DS (1999). Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against themral or hypoxic stress. Journal of Molecular and Cellular Cardiology, 31, 135 - 146.
    • Brar BK, Jonassen AK, Stephanou A, Santilli G, Knight RA, Yellon DM, Latchman DS (1999). Urocortin protection of cardiac myocytes from lethal ischemic and ischemic reoxygenation injury both in vitro and ex vivo.
    • Stephanou A, Isenberg DA, Nakajima K, Latchman DS (1999). Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters.. J Biol Chem, 274(3), 1723 - 1728.
    • Stephanou AL, D S (1999). Transcriptional regulation of the heat shock protein genes by STAT family transcription factors.. Gene Expression, 7, 311 - 319.
    • Brar BK, Stephanou A, OkosI A, Lawrence KM, Knight RA, Marber MS, Latchman DS (1999). CRH-like peptides protect cardiac myocytes from lethal ischaemic injury. Molecular and Cellular Endocrinology, 158, 55 - 63.
    • Brar BS, Stephanou A, Wagstaff MJD, Coffin RS, Marber MS, Engelmann G, Latchman DS (1999). Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or ischaemic stress. Journal of Molecular and Cellular Cardiology, 31, 135 - 146.
    • Scarabelli TM, Rayment NB, Knight RA, Cooper TJ, Stephanou A, Brar BK, Latchman DS, Baxter GF, Yellon DM (1999). Occurrence of apoptosis in specific cell types in isolated perfused rat hearts exposed to ischaemia and reperfusion.
    • Scarabelli TM, Knight RA, Rayment NB, Cooper TJ, Stephanou A, Brar BK, Lawrence KM, Santilli G, Latchman DS, Baxter GF, Yellon DM (1999). Quantitative assessment of cardiac myocyte apoptosis in tissue sections using the fluorescence-based tunel technique enhanced with counterstains. Journal of Immunological Methods, 228(1-2), 23 - 28.
    • Scarabelli TM, Knight RA, Rayment NB, Cooper TJ, Stephanou A, Brar BK, Lawrence KM, Santilli G, Latchman DS, Baxter GF, Yellon DM (1999). Quantitative assessment of cardiac myocyte apoptosis in tissue sections using the fluorescence based TUNEL technique enhanced with counterstains. Journal of Immunological Methods, 228, 23 - 28.
    • Scarabelli TM, Knight RA, Rayment NB, Cooper TJ, Stephanou A, Brar BK, Lawrence KM, Sartilli G, Latchman DS, Baxter GF, Yellon DM (1999). Quantitative assessment of cardiac myocyte apoptosis in tissue sections using the fluorescence based TUNEL technique with counterstains. Journal of Immunological Methods, 228, 23 - 28.
    • Ripley BJM, Stephanou A, Isenberg DA, Latchman DS (1999). Interleukin-10 activates heat shock protein 90 gene expression. Immunology, 97, 226 - 231.

    1998

    • Stephanou A, Latchman DS, Isenberg DA (1998). The regulation of heat shock proteins and their role in systemic lupus erythematosus. SEMIN ARTHRITIS RHEUM, 28(3), 155 - 162.
    • Latchman DS, Stephanou A, Conroy S, Isenberg DA, Maione D, Poli V, Ciliberto G (1998). Elevation of IL-6 in transgenic mice results in increased levels of the 90kDa heat shock protein (hsp90) and the production of anti hsp90 antibodies. Journal of Autoimmunity, 11, 249 - 253.
    • Ripley BJM, Stephanou A, Latchman DS, Isenberg DA (1998). Interleukin-10 activates heat shock protein 90 (HSP90) gene expression.. ARTHRITIS RHEUM, 41(9), S284 - S284.
    • Latchman DS, Stephanou A, Isenberg DA (1998). The regulation of heat shock protein and its role in SLE. Seminars in arthritis and Rheumatism, 28, 155 - 162.
    • Latchman DS, Stephanou A, Brar B, Heads R, Knight RD, Marber MS, Pennica D (1998). Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli. Journal of Molecular and Cellular Cardiology, 30, 849 - 855.
    • Stephanou A, Isenberg DA, Akira S, Kishimoto T, Latchman DS (1998). The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat. BIOCHEM J, 330(Pt 1), 189 - 195.
    • Latchman DS, Okosi A, Brar BK, Chan M, De Souza L, Smith E, Stephanou A, Chowdry HS, Knight RA (1998). Expression and protective effects of urocortin in cardiac myocytes. Neuropeptides, 32, 167 - 171.
    • Latchman DS, Stephanou A (1998). Regulation of heat shock protein genes by cytokines. In Latchman DS (Ed.), Stress Proteins (pp. 153 - 171). : Springer Verlag.
    • Latchman DS, Stephanou A, Isenberg DA, Akira S, Kishimoto T (1998). The NF-IL6 and STAT-3 signalling pathways co-operate to mediate the activation of the hsp90( gene by IL-6 but have opposite effects on its inducibility by heat shock. Biochemical Journal, 330, 189 - 195.

    1997

    • Stephanou A, Amin V, Isenberg DA, Akira S, Kishimoto T, Latchman DS (1997). Interleukin-6 activates heat shock protein 90á gene expression. Biochemical Journal, 321, 103 - 106.
    • Stephanou A, Okosi A, Knight RA, Chowdrey HS, Latchman DS (1997). C/EBP activates the human corticotrophin releasing hormone gene promoter. Molecular and Cellular Endocrinology, 134, 41 - 50.
    • Stephanou A, Amin V, Isenberg DA, Akira S, Kishimoto T, Latchman DS (1997). Interleukin 6 activates heat-shock protein 90 beta gene expression. Biochemical Journal, 321(1), 103 - 106.

    1996

    • Stephanou A, Shah M, Richardson B, Handwerger S (1996). The ARP-1 orphan receptor represses steroid-mediated stimulation of human placental lactogen gene expression.. J Mol Endocrinol, 16(3), 221 - 227.
    • Stephanou AH, S (1996). ARP-1 represses steroid-mediated stimulation of hPL gene expression. Journal of Molecular Endocrinology, 16, 221 - 227.
    • Caticha O, Norato DY, Tambascia MA, Santana A, Stephanou A, Sarlis NJ (1996). Total body zinc depletion and its relationship to the development of hyperprolactinemia in chronic renal insufficiency.. J Endocrinol Invest, 19(7), 441 - 448.

    1995

    • Stephanou A, Handwerger S (1995). Retinoic acid and thyroid hormone regulate placental lactogen expression in human trophoblast cells.. , 136, 933 - 938.
    • Stephanou A, Handwerger S (1995). Identification of a composite steroid hormone response element on the human placental lactogen promoter.. Mol Cell Endocrinol, 112(1), 123 - 129.
    • Stephanou AH, S (1995). Ontogeny of the expression and regulation of IL-6 and IL-1 mRNA by human trophoblast cells during differentiation. Journal of Endocrinology, 144, 487 - 496.
    • Stephanou AH, S (1995). Identification of a composite steroid hormone response element on the hPL promoter.. Molecular and Cellular Endocrinology, 112, 123 - 129.
    • Stephanou A, Myatt L, Eis AL, Sarlis N, Jikihara H, Handwerger S (1995). Ontogeny of the expression and regulation of interleukin-6 (IL-6) and IL-1 mRNAs by human trophoblast cells during differentiation in vitro.. J Endocrinol, 147(3), 487 - 496.
    • Stephanou A, Handwerger S (1995). The nuclear factor NF-IL6 activates human placental lactogen gene expression.. Biochem Biophys Res Commun, 206(1), 215 - 222. doi:10.1006/bbrc.1995.1030

    1994

    • Stephanou A, Ross R, Handwerger S (1994). Regulation of human placental lactogen expression by 1,25-dihydroxyvitamin D3.. Endocrinology, 135, 2651 - 2656.
    • Stephanou A, Sarlis NJ, Richards R, Handwerger S (1994). Expression of retinoic acid receptor subtypes and cellular retinoic acid binding protein-II mRNAs during differentiation of human trophoblast cells.. Biochem Biophys Res Commun, 202(2), 772 - 780. doi:10.1006/bbrc.1994.1997
    • Stephanou A, Sarlis NJ, Richards R, Handwerger S (1994). Expression of RAR subtypes and CRABP-II mRNA during differentiation of human trophoblast cells. , 202, 772 - 780.
    • Stephanou AH, S (1994). NF-IL6 activates the hPL gene promoter. Biochemical and Biophysical Research Communications, 206, 215 - 222.
    • Stephanou A, Handwerger S (1994). nterleukin-6 stimulates placental lactogen expression by human trophoblast cells.. , 135, 719 - 723.

    1993

    • Melino G, Stephanou A, Annicchiarico-Petruzzelli M, Knight RA, Finazzi-Agró A, Lightman SL (1993). Modulation of IGF-2 expression during growth and differentiation of human neuroblastoma cells: retinoic acid may induce IGF-2.. Neurosci Lett, 151(2), 187 - 191.
    • Melino G, Stephanou A, Annicchiarico-Petruzzelli M, Knight RA, Finazzi-Agró A, Lightman SL (1993). Modulation of IGF-2 expression during growth and differentiation of human neuroblastoma cells: retinoic acid may induce IGF-2.. Neuroscience Letters, 151, 187 - 191.
    • Knight RA, Stephanou A, Sarlis NJ, Chowdrey HS, Lightman SL (1993). Direct stimulation of the pituitary by transfer of activated leucocytes.. , 5, 229 - 231.
    • Sarlis NJ, Stephanou A, Knight RA, Lightman SL, Chowdrey HS (1993). Effects of glucocorticoids and chronic inflammatory stress upon anterior pituitary interleukin-6 mRNA expression in the rat.. British Journal of Rheumatology, 32, 653 - 657.
    • Knight RA, Stephanou A, Sarlis NJ, Chowdrey HS, Lightman SL (1993). Direct stimulation of the pituitary by transfer of activated leucocytes.. J Neuroendocrinol, 5(3), 229 - 231.
    • Sarlis NJ, Stephanou A, Knight RA, Lightman SL, Chowdrey HS (1993). Effects of glucocorticoids and chronic inflammatory stress upon anterior pituitary interleukin-6 mRNA expression in the rat.. Br J Rheumatol, 32(8), 653 - 657.

    1992

    • Stephanou A, Melino G, Knight RA, Annicchiarico-Petruzzelli M, Sarlis NJ, Finazzi-Agro A, Lightman SL (1992). Interleukin-6 and corticotrophin-releasing hormone mRNA are modulated during differentiation of human neuroblastoma cells.. Neuropeptides, 23(1), 45 - 49.
    • Harbuz MS, Stephanou A, Knight RA, Chover-Gonzalez AJ, Lightman SL (1992). Action of interleukin-2 and interleukin-4 on CRF mRNA in the hypothalamus and POMC mRNA in the anterior pituitary.. Brain Behav Immun, 6(3), 214 - 222.
    • Stephanou A, Sarlis NJ, Knight RA, Lightman SL, Chowdrey HS (1992). Glucocorticoid-mediated responses of plasma ACTH and anterior pituitary pro-opiomelanocortin, growth hormone and prolactin mRNAs during adjuvant-induced arthritis in the rat.. J Mol Endocrinol, 9(3), 273 - 281.
    • Stephanou A, Sarlis NJ, Knight RA, Lightman SL, Chowdrey HS (1992). Effects of cyclosporine A on the hypothalamic-pituitary-adrenal axis and anterior pituitary interleukin-6 mRNA expression during chronic inflammatory stress in the rat.. J Neuroimmunol, 41(2), 215 - 222.
    • Harbuz MS, Stephanou A, Sarlis N, Lightman SL (1992). The effects of recombinant human interleukin (IL)-1 alpha, IL-1 beta or IL-6 on hypothalamo-pituitary-adrenal axis activation.. J Endocrinol, 133(3), 349 - 355.
    • Sarlis NJ, Chowdrey HS, Stephanou A, Lightman SL (1992). Chronic activation of the hypothalamo-pituitary-adrenal axis and loss of circadian rhythm during adjuvant-induced arthritis in the rat.. Endocrinology, 130(4), 1775 - 1779. doi:10.1210/endo.130.4.1312424
    • Savarese A, Annicchiarico-Petruzzelli M, Citro G, Zupi G, Spagnoli LG, Colantoni A, Vernole P, Stephanou A, Knight RAGP (1992). Characterisation of a human glioblastoma cell line (LI) expressing hypothalamic and pituitary hormones.. Experimental Brain Research, 89, 408 - 414.
    • Sarlis NJ, Chowdrey HS, Stephanou A, Lightman SL (1992). Chronic activation of the hypothalamo-pituitary-adrenal axis and loss of circadian rhythm during adjuvant-induced arthritis in the rat. Endocrinology, 130(4), 1775 - 1779.
    • Stephanou A, Sarlis NJ, Knight RA, Lightman SL, Chowdrey HS (1992). Effects of cyclosporine A on the hypothalamic-pituitary-adrenal axis and anterior pituitary interleukin-6 mRNA expression during chronic inflammatory stress in the rat.. Journal of Neuroimmunology, 41, 215 - 222.
    • Knight R, Sarlis N, Stephanou A (1992). Interleukins and neurohormones: a common language.. Postgraduate Medical Journal, 68, 603 - 605.
    • Melino G, Stephanou A, Annicchiarico-Petruzzelli M, Finazzi-Agró A, Knight RA, Lightman SL (1992). IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth.. Neuroscience Letters, 144, 25 - 28.
    • Harbuz MS, Stephanou A, Sarlis N, Lightman SL (1992). The effects of recombinant human interleukin (IL)-1 alpha, IL-1 beta or IL-6 on hypothalamo-pituitary-adrenal axis activation.. Journal of Endocrinology, 133, 349 - 355.
    • Stephanou A, Sarlis NJ, Knight RA, Chowdrey HS, Lightman SL (1992). Response of pituitary and spleen pro-opiomelanocortin mRNA, and spleen and thymus interleukin-1 beta mRNA to adjuvant arthritis in the rat.. Journal of Neuroimmunology, 37, 59 - 63.
    • Stephanou A, Sarlis NJ, Knight RA, Lightman SL, Chowdrey HS (1992). Glucocorticoid-mediated responses of plasma ACTH and anterior pituitary pro-opiomelanocortin, growth hormone and prolactin mRNAs during adjuvant-induced arthritis in the rat.. Journal of Molecular Endocrinology, 9, 273 - 281.
    • Stephanou A, Melino G, Knight RA, Annicchiarico-Petruzzelli M, Sarlis NJ, Finazzi-Agro A, Lightman SL (1992). Interleukin-6 and corticotrophin-releasing hormone mRNA are modulated during differentiation of human neuroblastoma cells.. Neuropeptides, 23, 45 - 49.
    • Harbuz MS, Stephanou A, Knight RA, Chover-Gonzalez AJ, Lightman SL (1992). Action of interleukin-2 and interleukin-4 on CRF mRNA in the hypothalamus and POMC mRNA in the anterior pituitary.. Brain, Behavior, and Immunity, 6, 214 - 222.
    • Melino G, Vernole P, Annicchiarico-Petruzzelli M, Stephanou A, Colantoni A, Knightm R A SLG, Finazzi-Agro A (1992). An inducible cell line (Natasha), from a neuroblastoma patient with circulating HSR-positive blasts, expressing neurohormones.. Anticancer Res., 12, 1199 - 1206.
    • Stephanou A, Knight RA, Annicchiarico-Petruzzelli M, Finazzi-Agrò A, Lightmann SL, Melino G (1992). Interleukin-1 beta and interleukin-6 mRNA are expressed in human glioblastoma and neuroblastoma cells respectively.. Funct Neurol, 7(2), 129 - 133.
    • SARLIS NJ, STEPHANOU A, CHOWDREY HS, KNIGHT RA, LIGHTMAN SL (1992). PITUITARY-ADRENAL AXIS AND ANTERIOR-PITUITARY PROLACTIN AND GROWTH-HORMONE MESSENGER-RNA RESPONSES OF ADJUVANT-ARTHRITIC RATS TO CYCLOSPORINE-A ARE DEPENDENT UPON THE TIME OF ITS ADMINISTRATION. PROG NEUROENDOCRINIM, 5(2), 141 - 150.
    • HARBUZ MS, STEPHANOU A, KNIGHT RA, CHOVERGONZALEZ AJ, LIGHTMAN SL (1992). ACTION OF INTERLEUKIN-2 AND INTERLEUKIN-4 ON CRF MESSENGER-RNA IN THE HYPOTHALAMUS AND POMC MESSENGER-RNA IN THE ANTERIOR-PITUITARY. BRAIN BEHAV IMMUN, 6(3), 214 - 222.
    • Stephanou A, Sarlis NJ, Knight RA, Chowdrey HS, Lightman SL (1992). Response of pituitary and spleen pro-opiomelanocortin mRNA, and spleen and thymus interleukin-1 beta mRNA to adjuvant arthritis in the rat.. J Neuroimmunol, 37(1-2), 59 - 63.
    • Melino G, Stephanou A, Annicchiarico-Petruzzelli M, Finazzi-Agró A, Knight RA, Lightman SL (1992). IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth.. Neurosci Lett, 144(1-2), 25 - 28.

    1991

    • Stephanou A, Knight RA, De Laurenzi V, Melino G, Lightman SL (1991). Expression of pre-opiomelanocortin (POMC) mRNA in undifferentiated and in vitro differentiated human neuroblastoma cell lines.. Prog Clin Biol Res, 366, 173 - 180.
    • Stephanou A, Knight RA, De Laurenzi V, Melino G, Lightman SL (1991). Expression of pre-opiomelanocortin (POMC) mRNA in undifferentiated and in vitro differentiated human neuroblastoma cell lines.. Progress in Clinical and Biological Research, 366, 173 - 180.
    • Stephanou A, Knight RA, Lightman SL (1991). Production of a growth hormone-releasing hormone-like peptide and its mRNA by human lymphocytes.. Neuroendocrinology, 53(6), 628 - 633.
    • Stephanou A, Fitzharris P, Knight RA, Lightman SL (1991). Characteristics and kinetics of proopiomelanocortin mRNA expression by human leucocytes.. Brain, Behavior, and Immunity, 5, 319 - 327.
    • Stephanou A, Knight RA, S L (1991). Production of a growth hormone-releasing hormone-like peptide and its mRNA by human lymphocytes.. Neuroendocrinology., 53, 628 - 633.
    • Stephanou A, Fitzharris P, Knight RA, Lightman SL (1991). Characteristics and kinetics of proopiomelanocortin mRNA expression by human leucocytes.. Brain Behav Immun, 5(4), 319 - 327.

    1990

    • Stephanou A, Jessop DS, Knight RA, Lightman SL (1990). Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes.. Brain Behav Immun, 4(1), 67 - 73.
    • STEPHANOU A, LIGHTMAN SL, KNIGHT RA, MELINO G (1990). EXPRESSION OF PROOPIOMELANOCORTIN AND CORTICOTROPIN RELEASING-FACTOR MESSENGER-RNA IN HUMAN-LYMPHOCYTES AND NEUROBLASTOMAS.
    • Stephanou A, Jessop DS, Knight RA, Lightman SL (1990). Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes.. Brain, Behavior, and Immunity, 4, 67 - 73.
    • KNIGHT RA, STEPHANOU A, LIGHTMAN SL, WILLIAMSON SA (1990). CRF AND POMC PRODUCTION BY NEUROECTODERMAL TUMORS AND LYMPHOCYTES, AND ITS IMMUNOLOGICAL CONSEQUENCES.

    1984

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