Prof Andrew Copp

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Name: Andrew Copp Email: a.copp@ucl.ac.uk
Title: Prof Tel: 020 7905 2355
Department: ICH - Neural Development Unit Fax: 020 7905 2953
Position: Glaxo-Wellcome Professor of Developmental Neurobiology Address: UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH
Research Domain: Experimental Medicine, Genetics (Frontier Disciplines), Neuroscience, Personalised Medicine, Populations & Lifelong Health, Reproduction & Development, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

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Research Description

My research is concerned with the embryonic mechanisms underlying central nervous system development and congenital disorders. The laboratory is known internationally for its expertise in animal models of birth defects, particularly neural tube defects (e.g. spina bifida).  It is the first lab in the world to take a potential new therapy for a birth defect, worked out in mouse models (i.e. inositol for prevention of folic acid-resistant neural tube defects), and to apply it to human pregnancy through a clinical trial, the PONTI study (http://www.ucl.ac.uk/ich/research-ich/neural-development/ponti_study).  If this trial has a positive outcome, it would be the first innovation in primary prevention of a significant human birth defect since the research on folic acid in the late 1980s. My research team is supported by grants from the Wellcome Trust, Medical Research Council, SPARKS (Sport Aiding Medical Research in Kids), Newlife Foundation for Disabled Children and the Bo Hjelt Spina Bifida Foundation.


Significant research landmarks have included:

(i) Identification of inositol as an adjunct to folic acid for preventing spina bifida in the mouse (Nature Medicine, 1997; Human Molecular Genetics, 2004) with translation of these findings into a current clinical trial;


(ii) Identification of a mouse model of folic acid-preventable neural tube defects (Science, 1998), and the  finding of an inborn error of folate metabolism in human fetuses with neural tube defects (Brain, 2007). We have gone on to identify missense mutations in mitochondrial folate metabolic genes in patients with neural tube defects (Human Molecular Genetics, 2012);


(iii) Elucidation of genetic and developmental mechanisms, including key roles for sonic hedgehog and BMP signalling, in the origin of spina bifida in several mouse mutant strains (Development, 2002, 2007);


(iv) Demonstration that the planar cell polarity (PCP) pathway is crucial for the initiation of neural tube closure.  In its absence severe neural tube defects result  (Human Molecular Genetics, 2001,2003; Current Biology, 2003; Development, 2013).  We identified PCP mutations in a series of human fetuses with severe NTDs (Human Mutation, 2013).


(v) Resolution of a controversy over the role of programmed cell death (apoptosis) in neural tube closure, which the Copp laboratory recently showed to be non-essential (Proceedings of the National Academy of Sciences USA, 2009).


(vi) Publication of a series of highly cited review articles on the development of the neural tube and NTDs (Progress in Neurobiology, 1990; Nature Reviews Genetics, 2003; Lancet Neurology, 2013)


Research Activities

Development of Neural Tube Defects

Developmental biology of the nervous system with particular reference to congenital malformations

Genetics of early CNS malformations, cleft lip and cleft palate

Education Description

Research student supervision at PhD level, together with supervision of laboratory and library projects for MSc and BSc students at UCL and beyond. Co-organiser of the Wellcome Trust 4 year PhD programme in Developmental and Stem Cell Biology. Supervisor on Wellcome Trust 4-year PhD programme in Neuroscience.

Lectures on normal and abnormal development of the CNS, with specific reference to neural tube defects:

(i) MSc in Prenatal Genetics and Fetal Medicine;
(ii) MBBS, 2nd year course in Reproduction, Development and Genetics.

UCL Collaborators

Prof Peter Scambler; Dr Kevin Mills; Dr Mike Hubank; Prof Gudrun Moore; Dr Erwin Pauws; Prof Nicholas Greene; Dr Philip Stanier

External Collaborators

Publications

    2014

    • Norris FC, Siow BM, Cleary JO, Wells JA, De Castro SC, Ordidge RJ, Greene ND, Copp AJ, Scambler PJ, Alexander DC, Lythgoe MF (2014). Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model.. Magn Reson Med, , - . doi:10.1002/mrm.25145

    2013

    • Papakrivopoulou E, Dean CH, Copp AJ, Long DA (2013). Planar cell polarity and the kidney.. Nephrol Dial Transplant, , - . doi:10.1093/ndt/gft484
    • Carnaghan H, Roberts T, Savery D, Norris F, McCann CJ, Copp AJ, Scambler P, Lythgoe M, Greene NDE, DeCoppi P, Burns A, Pierro A, Eaton S (2013). Novel exomphalos genetic mouse model: the importance of accurate phenotypic characterisation.. Journal of Pediatric Surgery, 48(10), 2036 - 2042. doi:10.1016/j.jpedsurg.2013.04.010.
    • Leung K-Y, De Castro SCP, Savery D, Copp AJ, Greene NDE (2013). Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse.. Brain, , - . doi:10.1093/brain/awt209
    • Peake JN, Copp AJ, Shawe J (2013). Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: Systematic review and meta-analysis.. Birth Defects Res A Clin Mol Teratol, 97(7), 444 - 451. doi:10.1002/bdra.23154
    • Adams D, Baldock R, Bhattacharya S, Copp AJ, Dickinson M, Greene NDE, Henkelman M, Justice M, Mohun T, Murray SA, Pauws E, Raess M, Rossant J, Weaver T, West D (2013). Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening. Disease Models & Mechanisms, 6(3), 571 - 579. doi:10.1242/dmm.011833
    • Copp AJ, Stanier P, Greene NDE (2013). Neural tube defects – recent advances, unsolved questions and some controversies.. Lancet Neurology, 12, 799 - 810. doi:10.1016/S1474-4422(13)70110-8
    • Robinson R, Partridge D, Malhas A, De Castro SCP, Gustavsson P, Thompson DN, Vaux DJ, Copp AJ, Stanier P, Bassuk AG, Greene NDE (2013). Is LMNB1 a susceptibility gene for neural tube defects in humans?. Birth Defects Research Part A: Clinical and Molecular Teratology, , - . doi:10.1002/bdra.23141
    • Mohun T, Adams DJ, Baldock R, Bhattacharya S, Copp AJ, Hemberger M, Houart C, Hurles ME, Robertson E, Smith JC, Weaver T, Weninger W (2013). Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice.. Dis Model Mech, 6(3), 562 - 566. doi:10.1242/dmm.011957
    • Leung KY, De Castro SC, Cabreiro F, Gustavsson P, Copp AJ, Greene ND (2013). Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain.. Mol Cell Biochem, 378(1-2), 229 - 236. doi:10.1007/s11010-013-1613-y
    • Escobedo N, Contreras O, Munoz R, Farias M, Carrasco H, Hill C, Tran U, Pryor SE, Wessely O, Copp AJ, Larrain J (2013). Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Development., 140, 3008 - 3017. doi:10.1242/dev.091173

    2012

    • Copp AJ, Greene NDE (2012). Neural Tube Defects – disorders of neurulation and related embryonic processes.. WIREs Dev Biol, , - . doi:10.1002/wdev.71
    • Gerrelli D, Suren S, Morrison V, Cheng Y, Overman L, Crosier M, Lisgo S, Lindsay S, Copp AJ (2012). Assisting research into human embryonic and fetal development.
    • Pai YJ, Leung KY, Savery D, Copp AJ, Greene NDE (2012). Investigating the role of mitochondrial folate metabolism in neural tube defects.
    • Copp A (2012). Neural tube defects-Genetics, development and prevention. doi:10.1016/j.ijdevneu.2012.10.079
    • De Castro SCP, Malhas A, Leung K-Y, Gustavsson P, Vaux DJ, Copp AJ, Greene NDE (2012). Lamin B1 Polymorphism Influences Morphology of the Nuclear Envelope, Cell Cycle Progression and Risk of Neural Tube Defects in Mice.. PLoS Genetics, 8(11), - . doi:10.1371/journal.pgen.1003059
    • Robinson A, Escuin S, Doudney K, Vekemans M, Stevenson RE, Greene ND, Copp AJ, Stanier P (2012). Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.. Hum Mutat, 33(2), 440 - 447. doi:10.1002/humu.21662
    • Lopez-Escobar B, De Felipe B, Sanchez-Alcazar JA, Sasaki T, Copp AJ, Ybot-Gonzalez P (2012). Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.. Dev Dyn, 241(11), 1808 - 1815. doi:10.1002/dvdy.23846
    • Greene ND, Copp AJ (2012). Could microRNAs be biomarkers for neural tube defects?. J Neurochem, 122(3), 485 - 486. doi:10.1111/j.1471-4159.2012.07800.x
    • Narisawa A, Komatsuzaki S, Kikuchi A, Niihori T, Aoki Y, Fujiwara K, Tanemura M, Hata A, Suzuki Y, Relton CL, Grinham J, Leung KY, Partridge D, Robinson A, Stone V, Gustavsson P, Stanier P, Copp AJ, Greene ND, Tominaga T, Matsubara Y, Kure S (2012). Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum.Mol.Genet, 21, 1496 - 1503. doi:10.1093/hmg/ddr585
    • Pryor SE, Massa V, Savery D, Greene NDE, Copp AJ (2012). Convergent extension analysis in mouse whole embryo culture.. Methods in Molecular Biology, 839, 133 - 146. doi:10.1007/978-1-61779-510-7_11
    • Greene NDE, Copp AJ (2012). Spina bifida. In (Ed.), Brenner’s Encyclopedia of Genetics (pp. - ). : Elsevier.
    • Pai YJ, Abdullah NL, Mohd-Zin SW, Mohammed RS, Rolo A, Greene ND, Abdul-Aziz NM, Copp AJ (2012). Epithelial fusion during neural tube morphogenesis.. Birth Defects Res A Clin Mol Teratol, 94(10), 817 - 823. doi:10.1002/bdra.23072

    2011

    • Gerrelli D, Suren S, Morrison V, Cheng Y, Overman L, Crosier M, Lisgo S, Lindsay S, Copp AJ (2011). Assisting research into human embryonic and fetal development.
    • Raza-Knight S, Massa V, Savery D, Greene NDE, Copp AJ (2011). Mechanisms underlying spina bifida in the Zic2 loss-of-function mutant, Kumba.
    • Leung KY, Mills K, Burren KA, Copp AJ, Greene ND (2011). Quantitative analysis of myo-inositol in urine, blood and nutritional supplements by high-performance liquid chromatography tandem mass spectrometry.. J Chromatogr B Analyt Technol Biomed Life Sci, 879(26), 2759 - 2763. doi:10.1016/j.jchromb.2011.07.043
    • Copp AJ, Carvalho R, Wallace A, Sorokin L, Sasaki T, Greene NDE, Ybot-Gonzalez P (2011). Regional differences in the expression of laminin isoforms during mouse neural tube development.. Matrix Biology, 30, 301 - 309. doi:10.1016/j.matbio.2011.04.001
    • Escobedo N, Farias M, Carrasco H, Contreras O, Tran U, Wessely O, Copp A, Larrain J (2011). Role of Syndecan-4 in mouse development. doi:10.1016/j.ydbio.2011.05.654
    • Brouns MR, De Castro SCP, Terwindt-Rouwenhorst EA, Massa V, Hekking JW, Hirst CS, Savery D, Munts C, Partridge D, Lamers W, Kohler E, Van Straaten HW, Copp AJ, GREENE N (2011). Over-expression of Grhl2 causes spina bifida in the Axial Defects mutant mouse. Human Molecular Genetics, 20, 1536 - 1546. doi:10.1093/hmg/ddr031
    • Leong G, Copp AJ, Yip GW (2011). Role of glycosaminoglycans in murine primary spinal neurulation. doi:10.1016/j.ydbio.2011.05.173

    2010

    • Ferretti P, Copp A, Tickle C, Moore G (2010). Embryos, Genes and Birth Defects: Second Edition. doi:10.1002/9780470090121
    • Copp AJ (2010). Brain and Spinal Cord. In (Ed.), (pp. 167 - 198). : . doi:10.1002/9780470090121.ch8
    • Ferretti P, Copp A, Tickle C, Moore G (2010). Embryos, Genes and Birth Defects: Second Edition. doi:10.1002/9780470090121
    • Shum ASW, Tang LSC, Copp AJ, Roelink H (2010). Lack of Motor Neuron Differentiation Is an Intrinsic Property of the Mouse Secondary Neural Tube. Dev Dynam, 239(12), 3192 - 3203. doi:10.1002/dvdy.22457
    • Murdoch JN, Copp AJ (2010). The relationship between sonic hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol, 88(8), 633 - 652. doi:10.1002/bdra.20686
    • Copp AJ, Greene NDE (2010). Genetics and development of neural tube defects. J.Pathol., 220, 217 - 230.
    • Burren KA, Scott JM, Copp AJ, Greene ND (2010). The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly. Birth Defects Res.A Clin Mol.Teratol., 88, 76 - 83.
    • Robinson A, Doudney K, Greene NDE, Stanier P, Copp AJ (2010). Identification of putative neural tube defect-causing mutations in planar cell polarity genes.
    • Ioannides AS, Massa V, Ferraro E, Cecconi F, Spitz L, Henderson DJ, Copp AJ (2010). Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death.. Dev Biol, 337(2), 351 - 362. doi:10.1016/j.ydbio.2009.11.005
    • Copp AJ, Greene NDE (2010). Defining a PARticular pathway of neural tube closure.. Developmental Cell, 18, 1 - 2.
    • De Castro SC, Leung KY, Savery D, Burren K, Rozen R, Copp AJ, Greene ND (2010). Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.. Birth Defects Res A Clin Mol Teratol, 88(8), 612 - 618. doi:10.1002/bdra.20690

    2009

    • Greene ND, Stanier P, Copp AJ (2009). Genetics of human neural tube defects. Human Molecular Genetics, 18, R113 - R129.
    • Cao SF, Copp AJ, Yip GWC (2009). Transcriptomic analysis of mammalian spinal neurulation.
    • Doudney K, Grinham J, Whittaker J, Lynch SA, Thompson D, Moore GE, Copp AJ, Greene ND, Stanier P (2009). Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects.. American Journal of Medical Genetics Part A, 149A(7), 1585 - 1589.
    • Greene NDE, Copp AJ (2009). Development of the vertebrate central nervous system: formation of the neural tube. Prenatal Diagnosis, 29, 303 - 311.
    • Ioannides AS, Copp AJ (2009). Embryology of oesophageal atresia. Seminars in Pediatric Surgery, 18(1), 2 - 11.
    • Greene NDE, Massa V, Copp AJ (2009). Understanding the causes and prevention of neural tube defects: Insights from the splotch mouse model. Birth Defects Research Part A-Clinical and Molecular Teratology, 85(4), 322 - 330.
    • Abdul-Aziz NM, Turmaine M, Greene ND, Copp AJ (2009). EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion. International Journal of Developmental Biology, , - . doi:10.1387/ijdb.082777na
    • Massa V, Savery D, Copp AJ, Greene NDE (2009). Acetylation and neural tube defects.
    • Massa V, Savery D, Ybot-Gonzalez P, Ferraro E, Rongvaux A, Cecconi F, Flavell R, Greene ND, Copp AJ (2009). Apoptosis is not required for mammalian neural tube closure.. Proceedings of the National Academy of Sciences of the United States of America, 106, 8233 - 8238.
    • Massa V, Greene ND, Copp AJ (2009). Do cells become homeless during neural tube closure?. Cell Cycle, 8(16), 2479 - 2480.
    • Gerrelli D, Lisgo S, Copp A, Lindsay S (2009). Human Developmental Biology Resource (HDBR): A unique resource for studying human embryo and fetal development.
    • Castro S, Leung KY, Savery D, Gustavsson P, Copp AJ, Greene NDE (2009). Identification of Lmnb1 as a possible modifier gene for neural tube defects in the mouse.
    • Raza S, Massa V, Greene N, Copp A (2009). Mechanisms of spina bifida in the Zic2-Kumba mouse.
    • De Castro SCP, Savery D, Gustavsson P, Leung KY, Copp AJ, Greene NDE (2009). Proteomic analysis of neural tube defects in the curly tail mouse.
    • Massa V, Ybot-Gonzalez P, Savery D, Gaston-Massuet C, Greene NE, Copp AJ (2009). Role of Zic2 in mammalian neural tube closure.
    • Cao SF, Copp AJ, Yip GWC (2009). Transcriptomic analysis of mammalian spinal neurulation. doi:10.1016/j.ydbio.2009.05.211

    2008

    • Harding BN, Copp AJ (2008). Malformations. In Love S, Louis DN, Ellison DW (Ed.), Greenfield's Neuropathology (pp. 335 - 479). : Hodder Arnold.
    • Gustavsson P, Copp AJ, Greene NDE (2008). Grainyhead genes and mammalian neural tube closure. Birth Defects Res. Part A: Clinical and Molecular Teratology, 82(10), 728 - 735.
    • Burren KA, Savery D, Massa V, Kok RM, Scott JM, Blom HJ, Copp AJ, Greene NDE (2008). Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.. Human Molecular Genetics, 17, 3675 - 3685. doi:10.1093/hmg/ddn262
    • Massa V, Ybot-Gonzalez P, Savery D, Greene NDE, Copp AJ (2008). Role of apoptosis in mammalian neurulation.

    2007

    • Stiefel D, Meuli M, Copp AJ (2007). Response.
    • Gustavsson P, Greene NDE, Lad D, Pauws E, de Castro SC, Stanier P, Copp AJ (2007). Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model. Human Molecular Genetics, 16(21), 2640 - 2646. doi:10.1093/hmg/ddm221
    • Ybot-Gonzalez P, Gaston-Massuet C, Girdler G, Klingensmith J, Arkell R, Greene ND, Copp AJ (2007). Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. Development, 134(17), 3203 - 3211.
    • Phillips HM, Rhee HJ, Murdoch JN, Hildreth V, Peat JD, Anderson RH, Copp AJ, Chaudhry B, Henderson DJ (2007). Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization. Circ.Res., 101(2), 137 - 145.
    • Dawe HR, Smith UM, Cullinane AR, Gerrelli D, Cox P, Badano JL, Blair-Reid S, Sriram N, Katsanis N, Attie-Bitach T, Afford SC, Copp AJ, Kelly DA, Gull K, Johnson CA (2007). The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. Human Molecular Genetics, 16(2), 173 - 186. doi:10.1093/hmg/ddl459
    • Dunlevy LP, Chitty LS, Burren KA, Doudney K, Stojilkovic-Mikic T, Stanier P, Scott R, Copp AJ, Greene ND (2007). Abnormal folate metabolism in foetuses affected by neural tube defects. Brain, 130(Pt 4), 1043 - 1049. doi:10.1093/brain/awm028
    • Ybot-Gonzalez P, Savery D, Gerrelli D, Signore M, Mitchell CE, Faux CH, Greene ND, Copp AJ (2007). Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development, 134(4), 789 - 799. doi:10.1242/dev.000380
    • Stiefel D, Copp AJ, Meuli M (2007). Fetal spina bifida - Response.
    • Stiefel D, Copp AJ, Meuli M (2007). Fetal spina bifida in a mouse model: loss of neural function in utero. J NEUROSURG, 106(3), 213 - 221.
    • Copp AJ, Greene NDE, Fisher EMC (2007). 17th Mammalian Genetics and Development Workshop of the Genetics Society - November 9-10, 2006 - London, England, UK - Abstracts. doi:10.1017/S0016672307008804

    2006

    • Chitty LS, Greene NDE, Burren K, Hesketh T, Copp A (2006). The PONTI (Prevention of neural tube defects by inositol) clinical trial.
    • Greene NDE, Copp AJ (2006). The embryonic basis of neural tube defects. In Wyszynski DF (Ed.), Neural Tube Defects: From Origin to Treatment (pp. 15 - 28). : Oxford University Press.
    • Chitty L, Greene NDE, Burren K, Hesketh T, Copp A (2006). Prevention of neural tube defects by inositol (PONTI).
    • Burren KA, Mills K, Copp AJ, Greene ND (2006). Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry. Journal of Chromatography B, 844, 112 - 118.
    • Ross A, May-Simera H, Eichers E, Kai M, Hill J, Jagger D, Leitch C, Chapple JP, Munro P, Fisher S, Tan P, Phillips H, Leroux M, Henderson D, Murdoch J, Copp A, Eliot MM, Lupski J, Kemp D, Dollfus H, Tada M, Katsanis N, Forge A, Beales P (2006). Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.
    • Dunlevy LP, Burren KA, Mills K, Chitty LS, Copp AJ, Greene ND (2006). Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res.A Clin.Mol.Teratol., 76(7), 544 - 552.
    • Dunlevy LP, Burren KA, Chitty LS, Copp AJ, Greene ND (2006). Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett., 580(11), 2803 - 2807.
    • Paracchini S, Thomas A, Castro S, Lai C, Paramasivam M, Wang Y, Keating BJ, Taylor JM, Hacking DF, Scerri T, Francks C, Richardson AJ, Wade-Martins R, Stein JF, Knight JC, Copp AJ, LoTurco J, Monaco AP (2006). The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. HUM MOL GENET, 15(10), 1659 - 1666. doi:10.1093/hmg/ddl089
    • Burren K, Copp AJ, Greene NDE (2006). Analysis of folate metabolism in the prevention of neural tube defects.
    • Burren KA, Chitty LS, Hesketh T, Greene NDE, Copp AJ (2006). Clinical trial of combined folic acid and inositol treatment for prevention of NTDs.
    • Ferretti P, Copp AJ, Tickle C, Moore GE (2006). Embryos, Genes and Birth Defects.
    • Greene NDE, Dunlevy LPE, Burren K, Chitty LC, A J (2006). Folate Metabolism and Neural Tube Defects.
    • Gustavsson P, Greene NDE, Ericsson B, Dahl N, Blennow E, Anneren G, Copp AJ, Nordenskjold M (2006). Genetic studies in Swedish patients with spina bifida.
    • Cooper JE, Greene NDE, Copp AJ (2006). Is neural crest cell delamination necessary for normal cranial neural tube closure?.
    • Cooper JG, N D E C, A J (2006). Is neural crest cell delamination necessary for normal cranial neural tube closure?.
    • Abdul-Aziz NM, Greene NDE, Copp AJ (2006). Molecular basis of neural fold adhesion and fusion in closure of the spinal neural tube.
    • Copp AJ, Greene NDE, Murdoch JN (2006). Mouse mutants as models of neural tube defects. In Wyszynski DF (Ed.), Neural Tube Defects: From Origin to Treatment (pp. 198 - 213). : Oxford University Press.
    • Ybot-Gonzalez P, Savery D, Mitchell CM, Greene NDE, Copp AJ (2006). RhoA signalling, convergent extension and neural tube defects.
    • Gustavsson P, Greene NDE, Ericsson B, Dahl N, Blennow E, Anneren G, Copp A, Nordenskjold M (2006). Spina bifida: From chromosomal abnormality to candidate gene.
    • Copp A (2006). The genetic basis of mammalian neurulation. doi:10.1016/j.toxlet.2006.06.107

    2005

    • Ivanova A, Signore M, Caro N, Greene ND, Copp AJ, Martinez-Barbera JP (2005). In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis, 43(3), 129 - 135.
    • Lindsay S, Copp AJ (2005). MRC-Wellcome Trust Human Developmental Biology Resource: enabling studies of human trends in genetics developmental gene expression. TRENDS GENET, 21(11), 586 - 590. doi:10.1016/j.tig.2005.08.011
    • Copp AJ (2005). Neurulation in the cranial region--normal and abnormal.. J Anat, 207(5), 623 - 635. doi:10.1111/j.1469-7580.2005.00476.x
    • Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A, Beales PL (2005). Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nature Genetics, 37(10), 1135 - 1140. doi:10.1038/ng1644
    • Gaston-Massuet C, Henderson DJ, Greene ND, Copp AJ (2005). Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system. Developmental Dynamics, 233(3), 1110 - 1115.
    • Vargha-Khadem F, Gadian DG, Copp A, Mishkin M (2005). FOXP2 and the neuroanatomy of speech and language.. Nat Rev Neurosci, 6(2), 131 - 138. doi:10.1038/nrn1605
    • Phillips HM, Murdoch JN, Chaudhry B, Copp AJ, Henderson DJ (2005). Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circulation Research, 96(3), 292 - 299.
    • Doudney K, Ybot-Gonzalez P, Paternotte C, Stevenson RE, Greene ND, Moore GE, Copp AJ, Stanier P (2005). Analysis of the planar cell polarity gene VANGL2 and its co- expressed paralogue VANGL1 in neural tube defect patients. American Journal of Medical Genetics Part A, 136A(1), 90 - 92.
    • Ybot-Gonzalez P, Copp AJ, Greene NDE (2005). Expression pattern of glypican-4 suggests multiple roles during mouse development. Developmental Dynamics, 233(3), 1013 - 1017.
    • Aziz NMA, Greene N, Copp A (2005). Molecular basis of neural fold adhesion and fusion in closure of the spinal neural tube.
    • Greene NDE, Copp AJ (2005). Mouse models of neural tube defects: Investigating preventive mechanisms. American Journal of Medical Genetics Part C-Seminars in Medical Genetics, 135C(1), 31 - 41.
    • Copp AJ (2005). Neural tube defects, Molecular Biology of. In Meyers RA (Ed.), Encyclopedia of Molecular Cell Biology and Molecular Medicine (pp. 119 - 138). : Wiley-VCH.
    • Petzold A, Stiefel D, Copp AJ (2005). Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele. Journal of Neurochemistry, 95(2), 594 - 598.

    2004

    • Ybot-Gonzalez P, Savery D, Greene ND, Copp AJ (2004). Initiation of mouse neural tube closure requires Rho kinase, but not JNK..
    • Chan WY, Cheung CS, Yung KM, Copp AJ (2004). Cardiac neural crest of the mouse embryo: axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect. Development, 131(14), 3367 - 3379.
    • Sharma PR, Anderson RH, Copp AJ, Henderson DJ (2004). Spatiotemporal analysis of programmed cell death during mouse cardiac septation. ANAT REC, 277A(2), 355 - 369.
    • Leung MB, Choy KW, Copp AJ, Pang CP, Shum AS (2004). Hyperglycaemia potentiates the teratogenicity of retinoic acid in diabetic pregnancy in mice. Diabetologia, 47(3), 515 - 522.
    • Copp AJ, EMC F (2004). Abstracts of papers presented at the fourteenth genetics society's mammalian genetics and development workshop held at the Institute of Child Health, University College London on 3 and 4 December 2003. doi:10.1017/S0016672304007104
    • Cogram P, Hynes A, Dunlevy LP, Greene ND, Copp AJ (2004). Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Human Molecular Genetics, 13(1), 7 - 14. doi:10.1093/hmg/ddh003
    • Ybot-Gonzalez P, Savery D, Greene ND, Copp AJ (2004). Initiation of mouse neural tube closure requires Rho kinase, but not JNK.
    • Murdoch J, Quint E, Curtin J, Henderson D, Greene N, Arkell R, Bogani D, Gerrelli D, Doudney K, Paternotte C, Cattanach B, Nolan P, Spurr N, Fisher E, Stanier P, Gray I, Steel K, Brown S, Copp A (2004). Mechanisms regulating the initiation of neural tube closure.
    • Copp AJ, Harding BN (2004). Neural tube defects. In Golden JA, Harding BN (Ed.), Developmental Neuropathology (pp. 2 - 13). : ISN Neuropath Press.
    • Ybot-Gonzalez P, Greene N, Copp A (2004). Rho kinase is required for convergent extension and initiation of mouse neural tube closure.
    • Copp A, Savery D, Murdoch J, Greene N (2004). Convergent extension is defective in loop-tail (Vang12) mouse embryos prior to failure of neural tube closure.

    2003

    • Lai CS, Gerrelli D, Monaco AP, Fisher SE, Copp AJ (2003). FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain, 126(11), 2455 - 2462. doi:10.1093/brain/awg247
    • Copp AJ, Greene NDE, Murdoch JN (2003). The genetic basis of mammalian neurulation. Nature Reviews Genetics, 4, 784 - 793.
    • Stiefel D, Shibata T, Meuli M, Duffy PG, Copp AJ (2003). Tethering of the spinal cord in mouse fetuses and neonates with spina bifida. Journal of Neurosurgery, 99(2 Supp), 206 - 213.
    • Ioannides A, Henderson D, Spitz L, Copp A (2003). Molecular mechanisms underlying tracheo-oesophageal development.
    • Greene NDE, Dunlevy LE, Copp AJ (2003). Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos. Anatomy and Embryology, 206(3), 185 - 191.
    • Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P, Copp AJ (2003). Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Human Molecular Genetics, 12(2), 87 - 98.
    • Copp AJ, Greene NDE, Murdoch JN (2003). Dishevelled: linking convergent extension with neural tube closure. Trends in Neuroscience, 26, 453 - 455.
    • Murdoch JN, Doudney K, Gerrelli D, Wortham N, Paternotte C, Stanier P, Copp AJ (2003). Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. Molecular and Cellular Neuroscience, 22(1), 62 - 74. doi:10.1016/S1044-7431(02)00021-0
    • Dunlevy LPE, Copp AJ, Greene NDE (2003). Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos.
    • Greene NDE, Dunlevy LPE, Copp AJ (2003). Homocysteine, folic acid and neural tube defects.
    • Solanki GA, Evans J, Copp AJ, Thompson DNP (2003). Multiple coexistent dysraphic pathologies. Child's Nervous System, 19, 376 - 379.
    • Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, EMC F, Nolan PM, Steel KP, SDM B, Gray IC, Murdoch JN (2003). Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. CURR BIOL, 12(13), 1129 - 1133. doi:10.1016/S0960-9822(03)00374-9
    • Ioannides AS, Henderson DJ, Spitz L, Copp AJ (2003). Role of Sonic hedgehog in the development of the trachea and oesophagus. Journal of Pediatric Surgery, 38(1), 29 - 36.
    • Dunlevy LPE, Copp AJ, Greene NDE (2003). The effect of methylation cycle intermediates on neural tube closure.
    • Carroll EA, Gerrelli D, Gasca S, Berg E, Beier DR, Copp AJ, Klingensmith J (2003). Cordon-bleu is a conserved gene involved in neural tube formation. Developmental Biology, 262(1), 16 - 31.

    2002

    • Downs KM, McHugh J, Copp AJ, Shtivelman E (2002). Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus.. Mech Dev, 119 Suppl 1, S31 - S38.
    • Greene NDE, Leung KY, Wait R, Begum S, Dunn MJ, Copp AJ (2002). Differential protein expression at the stage of neural tube closure in the mouse embryo. Journal of Biological Chemistry, 277(44), 41645 - 41651. doi:10.1074/jbc.M203607200
    • Ybot-Gonzalez P, Cogram P, Gerrelli D, Copp AJ (2002). Sonic hedgehog and the molecular regulation of mouse neural tube closure. Development, 129(10), 2507 - 2517.
    • Doudney K, Murdoch JN, Braybrook C, Paternotte C, Bentley L, Copp AJ, Stanier P (2002). Cloning and characterisation of Igsf9 in mouse and human: a new member of the IgCAM superfamily expressed in the developing nervous system. Genomics, 79, 663 - 670.
    • Murdoch JN, Doudney K, Paternotte C, Stanier P, Copp AJ (2002). Identification of the gene mutated in the loop-tail mouse, a model for severe neural tube defects..
    • Moore R, Ferretti P, Copp AJ, Thorogood P (2002). Blocking endogenous FGF-2 activity prevents cranial osteogenesis. Developmental Biology, 243(1), 99 - 114. doi:10.1006/dbio.2001.0533
    • Martinez-Barbera JP, Rodriguez TA, Greene NDE, Weninger WJ, Simeone A, Copp AJ, Beddington R, Dunwoodie S (2002). Folic acid prevents exencephaly in Cited2 deficient mice. Human Molecular Genetics, 11(3), 283 - 293. doi:10.1093/hmg/11.3.283
    • Greene NDE, Copp AJ (2002). Animal models of folate-related neural tube defects. In Massaro EJ, Rogers JM (Ed.), Folate and Human Development (pp. 283 - 293). : Humana Press Inc.
    • Cogram P, Tesh S, Tesh J, Wade A, Allan G, Greene ND, Copp AJ (2002). D-Chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects. Human Reproduction, 17(9), 2451 - 2458.
    • Ioannides AS, Chaudhry B, Henderson DJ, Spitz L, Copp AJ (2002). Dorsoventral patterning in oesophageal atresia with tracheo- oesophageal fistula: Evidence from a new mouse model. Journal of Pediatric Surgery, 37(2), 185 - 190.
    • Yip GW, Ferretti P, Copp AJ (2002). Heparan sulphate proteoglycans and spinal neurulation in the mouse embryo. Development, 129(9), 2109 - 2119.
    • Petiot A, Ferretti P, Copp AJ, Chan CT (2002). Induction of chondrogenesis in neural crest cells by mutant fibroblast growth factor receptors. Developmental Dynamics, 224(2), 210 - 221.
    • Cavalli P, Copp AJ (2002). Inositol and folate resistant neural tube defects. Journal of Medical Genetics, 39(2), E5 - .
    • Chan BWH, Chan KS, Koide T, Yeung SM, Leung MBW, Copp AJ, Loeken MR, Shiroishi T, Shum ASW (2002). Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes, 51, 2811 - 2816.
    • Chan WY, Tam WY, Yung KM, Cheung CS, Sham MH, Copp AJ (2002). Tracking down the migration of mouse neural creast cells. Neuroembryology, 2, 9 - 17.

    2001

    • Yip GW, Ferretti P, Copp AJ (2001). Abnormal accumulation of chondroitin sulphate in the splotch (Sp(2H)) mouse mutant.
    • Paternotte C, Murdoch JN, Doudney K, Stanier P, Copp AJ (2001). Severe neural tube defects in the loop-tail mouse result from mutation of loopin, a novel transmembrane protein..
    • Paternotte C, Murdoch JN, Doudney K, Stanier P, Copp AJ (2001). Severe neural tube defects in the loop-tail mouse result from mutations of loopin, a novel transmembrane protein..
    • Murdoch JN, Doudney K, Paternotte C, Copp AJ, Stanier P (2001). Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Human Molecular Genetics, 10(22), 2593 - 2601. doi:10.1093/hmg/10.22.2593
    • Costa C, Harding B, Copp AJ (2001). Neuronal migration defects in the Dreher (Lmx1a) mutant mouse: Role of disorders of the glial limiting membrane. Cerebral Cortex, 11(6), 498 - 505.
    • Doudney K, Murdoch J, Paternotte C, Copp AJ, Stanier P (2001). Fine mapping of the locus underlying the severe neural tube defect loop-tail.
    • Van Straaten HWM, Copp AJ (2001). Curly tail: a 50-year history of the mouse spina bifida model. Anatomy and Embryology, 203(4), 225 - 237.
    • Doudney K, Murdoch JN, Patternotte C, Bently L, Gregory S, Copp AJ, Stanier P (2001). Comparative physical and transcript maps of similar to 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. Genomics, 72(2), 180 - 192.
    • Murdoch JN, Rachel RA, Shah S, Beermann F, Stanier P, Mason CA, Copp AJ (2001). Circletail, a new mouse mutant with severe neural tube defects: Chromosomal localization and interaction with the loop-tail mutation. Genomics, 78(1-2), 55 - 63.
    • Murdoch J, Rivka RA, Shah SS, Beerman F, Stanier P, Mason CA, Copp AJ (2001). Circletail, a new mouse mutant with a severe neural tube defect, maps to Chromosome 15..
    • Yip GW, Ferretti P, Copp AJ (2001). Abnormal accumulation of chondroitin sulphate in the splotch (Sp(2H)) mouse mutant.
    • (2001). Abnormal accumulation of chondroitin sulphate in the splotch.
    • Sarkar S, Petiot A, Copp A, Ferretti P, Thorogood P (2001). FGF2 promotes skeletogenic differentiation of cranial neural crest cells.. Development, 128(11), 2143 - 2152.
    • Henderson D, Conway SJ, Greene NDE, Gerrelli D, Murdoch JN, Anderson RH, Copp AJ (2001). Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant. Circulation Research, 89(1), 6 - 12. doi:10.1161/hh1301.092497

    2000

    • Yip GW, Ferretti P, Copp AJ (2000). Heparan sulphate and its O-sulphate group in neural tube closure in the mouse embryo.
    • Yip GW, Ferretti P, Copp AJ (2000). Sulphated glycosaminoglycans are required for neural tube closure in the mouse embryo.
    • Henderson DJ, Ybot-Gonzalez P, Copp AJ (2000). RHoB is expressed in migrating neural crest and endocardial cushions of the developing mouse embryo. MECHANISMS OF DEVELOPMENT, 95, 211 - 214.
    • Rachel RA, Murdoch JN, Beermann F, Copp AJ, Mason CA (2000). Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects. GENESIS, 27, 32 - 47.
    • Copp A, Cogram P, Fleming A, Gerrelli D, Henderson D, Hynes A, Kolatsi-Joannou M, Murdoch J, Ybot-Gonzalez P (2000). Neurulation and neural tube closure defects. Methods in Molecular Biology, 136, 135 - 160.
    • Copp AJ, Costa C (2000). Neuronal heterotopias in the Dreher mutant mouse - Disruption of the glial limiting membrane leads to neuronal overmigration.
    • (2000). The effect of FGF2 on developing choroid plexus in vitro.
    • Yip GW, Ferretti P, Copp AJ (2000). Heparan sulphate and its O-sulphate group in neural tube closure in the mouse embryo.
    • Paternotte C, Murdoch J, Doudney K, Eddleston J, Stanier P, Copp A (2000). Genetic mapping of loop-tail, a mouse mutant with a severe neural tube defect.
    • Murdoch JN, Rachel RA, Shah SS, Beermann F, Stanier P, Mason CA, Copp AJ (2000). Genetic mapping of circletail, a new mouse mutant with a severe neural tube defect.
    • Heinonen OP, Salonen T, Jalanko A, Peltonen L, Copp AJ (2000). CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain. The Journal of Comparative Neurology, 426, 406 - 412.
    • Fleming A, Copp AJ (2000). A genetic risk factor for mouse neural tube defects: defining the embryonic basis. Human Molecular Genetics, 9, 575 - 581.
    • Yip GW, Ferretti P, Copp AJ (2000). Heparan sulphate plays a role in closure of the neural tube in the mouse embryo.
    • Copp AJ, Greene ND (2000). Neural tube defects: prevention by folic acid and other vitamins. Indian Journal of Pediatrics, 67, 915 - 921.

    1999

    • Copp AJ, Harding BN (1999). Neuronal migration disorders in humans and in mouse models - an overview. Epilepsy Research, 36(2-3 SI), 133 - 141.
    • Copp AJ (1999). Neural tube defects. In (Ed.), Encyclopaedia of Life Sciences/www.els.net (pp. - ). : Nature Publishing Group.
    • Copp AJ, Henderson DJ (1999). Early development of the spine and spinal cord: general considerations. In Crockard A, Hayward R, Hoff JT (Ed.), Neurosurgery: the Scientific Basis of Clinical Practice (pp. 58 - 73). : Blackwell.
    • Eddleston J, Murdoch JN, Copp AJ, Stanier P (1999). Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics, 56(2), 149 - 159.
    • Copp A, Fleming A, Greene ND (1999). Preventing neural tube defects with vitamins - towards an understanding of hte molecular mechanisms.
    • Ybot-Gonzalez P, Copp AJ (1999). Bending of the neural plate during mouse spinal neurulation is independent of actin microfilaments.. Dev Dyn, 215(3), 273 - 283. doi:10.1002/(SICI)1097-0177(199907)215:3<273::AID-AJA9>3.0.CO;2-H
    • Shum ASW, Poon LLM, Tang WWT, Koide T, Chan BWH, Leung YCG, Shiroishi T, Copp AJ (1999). Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo (vol 84, pg 17, 1999).
    • Murdoch JN, Eddleston J, Leblond-Bourget N, Stanier P, Copp AJ (1999). Sequence and expression analysis of Nhlh1: a basic helix-loop-helix gene implicated in neurogenesis. Developmental Genetics, 24(1-2), 165 - 177.
    • Henderson DJ, Conway SJ, Copp AJ (1999). Rib truncations and fusions in the Sp(2H) mouse reveal a role for Pax3 in specification of the ventro-lateral and posterior parts of the somite. Developmental Biology, 209, 143 - 158.
    • Shum ASW, Poon LLM, Tang WWT, Koide T, Chan BWH, Leung YCG, Shiroishi T, Copp AJ (1999). Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. MECH DEVELOP, 84(1-2), 17 - 30.

    1998

    • Abu-Hayyeh S, Eddleston J, Murdoch JN, Tham M, Copp AJ, Stanier P (1998). Linkage mapping of Lims1, the murine homolog of the human LIM domain gene PINCH, to mouse chromosome 10.. Cytogenetics and Cell Genetics, 82, 46 - 48.
    • Copp AJ (1998). Prevention of neural tube defects: vitamins, enzymes and genes.. Curr Opin Neurol, 11(2), 97 - 102.
    • Greene ND, Gerrelli D, Van Straaten HW, Copp AJ (1998). Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech.Dev, 73(1), 59 - 72.
    • Fleming A, Copp AJ (1998). Embryonic folate metabolism and mouse neural tube defects.. Science, 280(5372), 2107 - 2109.
    • Sheward WJ, Lutz EM, Copp AJ, Harmar AJ (1998). Expression of PACAP, and PACAP type 1 (PAC(1)) receptor mRNA during development of the mouse embryo. DEV BRAIN RES, 109(2), 245 - 253.
    • Henderson DJ, Copp AJ (1998). Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart.. Circ Res, 83(5), 523 - 532.
    • Ferretti P, Copp A (1998). Peter Thorogood (1947-1998) - In memoriam.
    • Stanier P, Abu-Hayyeh S, Murdoch JN, Eddleston J, Copp AJ (1998). Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship.. Genomics, 51, 144 - 147.
    • Copp A, Fleming A, Greene NDE (1998). Embryonic mechanisms underlying the prevention of neural tube defects by vitamins. Mental Retardation & Developmental Disabilities Research Reviews, 4, 264 - 268.
    • Stanley LA, Copp AJ, Pope J, Rolls S, Smelt V, Perry VH, Sim E (1998). Immunochemical detection of arylamine N-acetyltransferase during mouse embryonic development and in adult mouse brain. Teratology., 58, 174 - 182.

    1997

    • Rossant J, Papaioannou VE, Lawson K, Fraser S, Copp A (1997). Cell lineages. doi:10.1016/S0890-6238(96)00214-6
    • Conway SJ, Henderson DJ, Anderson RH, Kirby ML, Copp AJ (1997). Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse. Cardiovascular Research, 36(2), 163 - 173.
    • Greene ND, Copp AJ (1997). Inositol prevents folate-resistant neural tube defects in the mouse.. Nature Medicine, 3, 60 - 66.
    • Murdoch JN, Eddleston J, Stanier P, Copp AJ (1997). Localisation of the mouse gene encoding tyrosine kinase receptor type 10 on distal Chromosome 1. Mammalian Genome, 8, 941 - 952.
    • Gerrelli D, Greene ND, Copp A (1997). Molecular analysis of loop-tail, a mouse model of craniorachischisis.
    • Gerrelli D, Greene ND, Van Straaten HW, Copp A (1997). Morphogenetic and molecular basis of severe neural tube defects in the mouse mutant loop-tail.
    • Conway SJ, Godt RE, Hatcher C, Leatherbury L, Zolotouchnikov VV, Brotto MAD, Copp AJ, Kirby ML, Creazzo TL (1997). Neural crest is involved in development of abnormal myocardial function. Journal of Molecular and Cellular Cardiology, 29(10), 2675 - 2685.
    • Copp AJ, Henderson DJ, Conway S (1997). Neural crest migration and congenital heart defects in the splotch mutant mouse.
    • Henderson DJ, Copp AJ (1997). Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch). Mechanisms of Development, 69, 39 - 51.
    • Conway SJ, Henderson DJ, Copp AJ (1997). Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development, 124(2), 505 - 514.
    • Henderson DJ, Copp AJ (1997). Role of the extracellular matrix in neural crest cell migration. Journal of Anatomy, 191, 507 - 515.
    • Copp AJ (1997). The neural tube. In Thorogood P (Ed.), Embryos, Genes and Birth Defects (pp. - ). : John Wiley & Sons.
    • Gerrelli D, Copp AJ (1997). Failure of neural tube closure in the loop-tail (Lp) mutant mouse: analysis of the embryonic mechanism. Developmental Brain Research, 102(2), 217 - 224.
    • Fleming A, Gerrelli D, Greene ND, Copp AJ (1997). Mechanisms of normal and abnormal neurulation: evidence from embryo culture studies. International Journal of Developmental Biology, 41(2), 199 - 212.

    1996

    • Hoyle C, Henderson DJ, Matthews DJ, Copp AJ (1996). Transferrin and its receptor in the development of genetically-determined neural tube defects in the mouse embryo. Dev.Dynamics, 207, 35 - 46.
    • David KM, Copp AJ, Stevens JM, Hayward RD, Crockard HA (1996). Split cervical spinal cord with Klippel-Feil syndrome: Seven cases. BRAIN, 119, 1859 - 1872.
    • Greene NDE, Copp AJ (1996). Inositol reduces the susceptibility of curly tail mutant mice to spinal neural tube defects.
    • Van Straaten HWM, Jansen HCJP, Peeters MCE, Copp AJ, Hekking JWM (1996). Neural tube closure in the chick embryo is multiphasic. Dev.Dynamics, 207, 309 - 318.
    • Shum ASW, Copp AJ (1996). Regional differences in morphogenesis of the neuroepithelium suggest multiple mechanisms of spinal neurulation in the mouse. Anat.Embryol.(Berl.), 194, 65 - 73.
    • Peeters MCE, Shum ASW, Hekking JWM, Copp AJ, Van Straaten HWM (1996). Relationship between altered axial curvature and neural tube closure in normal and mutant ( curly tail ) mouse embryos. Anat.Embryol.(Berl.), 193, 123 - 130.

    1995

    • STANIER P, HENSON JN, EDDLESTON J, MOORE GE, COPP AJ (1995). Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of Chromosome 1 syntenic with human 1q21-q23. GENOMICS, 26(3), 473 - 478.
    • Letts VA, Schork NJ, Copp AJ, Bernfield M, Frankel WN (1995). A curly-tail modifier locus, mct1, on mouse chromosome 17. Genomics, 29(3), 719 - 724.
    • Copp AJ (1995). The tale that wags the embryo. Reply.
    • Copp AJ (1995). Reply. Trends in Genetics, 11(8), 298 - 299.
    • Chen WH, Morriss-Kay GM, Copp AJ (1995). Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma. Development., 121, 681 - 691.
    • Copp AJ (1995). Death before birth: clues from gene knockouts and mutations in the mouse. Trends.Genet., 11(3), 87 - 93.
    • Lynch SA, Bond PM, Copp AJ, Kirwan WO, Nour S, Mariman E, Balling R, Burn J, Strachan T (1995). A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36. Nat.Genet., 11, 93 - 95.

    1994

    • Copp AJ (1994). Birth defects - from molecules to mechanisms. J.Roy.Coll.Phys., 28(4), 294 - 300.
    • Copp AJ (1994). Developmental mechanisms of birth defects - experimental and molecular approaches. In Donnai D, Smith SK, Ward RHT (Ed.), Early Fetal Growth and Development, Proceedings of the Twenty-Seventh Study Group of the Royal College of Obstetricians and Gynaecologists (pp. 49 - 60). : Royal College of Obstetricians and Gynaecologists.
    • Copp AJ, Bernfield M (1994). Etiology and pathogenesis of human neural tube defects: Insights from mouse models. Curr.Opin.Pediatr., 6(6), 624 - 631.
    • Brook FA, Estibeiro JP, Copp AJ (1994). Female predisposition to cranial neural tube defects is not because of a difference between the sexes in rate of embryonic growth or development during neurulation. J.Med.Genet., 31, 383 - 387.
    • Copp AJ (1994). Genetic models of mammalian neural tube defects. In Bock G, Marsh J (Ed.), Neural Tube Defects (Ciba Foundation Symposium 181) (pp. 118 - 134). : John Wiley & Sons.
    • Neumann PE, Frankel WN, Letts VA, Coffin JM, Copp AJ, Bernfield M (1994). Multifactorial inheritance of neural tube defects: Localization of the major gene and recognition of modifiers in ct mutant mice. Nat.Genet., 6, 357 - 362.
    • Chen WH, Morriss-Kay GM, Copp AJ (1994). Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid. Dev.Dynamics, 199, 93 - 102.
    • Copp AJ, Checiu I, Henson JN (1994). Developmental basis of severe neural tube defects in the loop-tail ( Lp ) mutant mouse: Use of microsatellite DNA markers to identify embryonic genotype. DB, 165, 20 - 29.

    1993

    • Copp AJ, Shum ASW, Brook FA (1993). Analysis of neural tube defects in a mouse mutant using whole embryo culture. Toxic.in Vitro, 7, 679 - 684.
    • Estibeiro JP, Brook FA, Copp AJ (1993). Interaction between splotch ( Sp ) and curly tail ( ct ) mouse mutants in the embryonic development of neural tube defects. Development., 119, 113 - 121.
    • Copp AJ (1993). Meeting report: Neural tube defects. TINS, 16, 381 - 383.
    • van Straaten HW, Hekking JW, Consten C, Copp AJ (1993). Intrinsic and extrinsic factors in the mechanism of neurulation: effect of curvature of the body axis on closure of the posterior neuropore. Development., 117(3), 1163 - 1172.

    1992

    • Van Straaten HWM, Hekking JWM, Copp AJ, Bernfield M (1992). Deceleration and acceleration in the rate of posterior neuropore closure during neurulation in the curly tail (ct) mouse embryo. Anat.Embryol.(Berl.), 185, 169 - 174.
    • Copp AJ, Estibeiro JP, Brook FA, Downs KM (1992). Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro. DB, 153, 312 - 323.
    • Cockroft DL, Brook FA, Copp AJ (1992). Inositol deficiency increases the susceptibility to neural tube defects of genetically predisposed (curly tail) mouse embryos in vitro. Teratology., 45, 223 - 232.

    1991

    • Copp AJ (1991). Growth and development of neural tube defects in the mammalian embryo. In Bernfield M, Cole FS (Ed.), Developmental Mechanisms of Disease in the Newborn. The 101st Ross Conference on Pediatric Research. (pp. 4 - 10). : Ross Laboratories.
    • Brook FA, Estibeiro JP, Copp AJ (1991). Relationship between rate of embryonic development and the preponderance of cranial neural tube defects in females.
    • Copp AJ (1991). Embryonic development: the origin of neural tube defects. In Chapman M, Grudzinskas JG, Chard T (Ed.), The Embryo; Normal and Abnormal Development and Growth (pp. 165 - 180). : Springer-Verlag.
    • Brook FA, Shum ASW, Van Straaten HWM, Copp AJ (1991). Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo. Development., 113, 671 - 678.

    1990

    • Estibeiro JP, Copp AJ, Cockroft DL, Brown NA, Clarke DO (1990). Extraction of macromolecules from embryonic material. In Copp AJ, Cockroft DL (Ed.), Postimplantation Mammalian Embryos: a Practical Approach (pp. 173 - 204). : IRL Press.
    • Estibeiro JP, Copp AJ (1990). A possible interaction between retarded splotch and curly tail.
    • Copp AJ (1990). Studying developmental mechanisms in intact embryos. In Copp AJ, Cockroft DL (Ed.), Postimplantation Mammalian Embryos: a Practical Approach (pp. 293 - 316). : IRL Press.
    • Copp AJ, Brook FA, Estibeiro JP, Shum ASW, Cockroft DL (1990). The embryonic development of mammalian neural tube defects. Prog.Neurobiol., 35, 363 - 403.
    • Copp AJ, Cockroft DL (1990). Postimplantation Mammalian Embryos: A Practical Approach.

    1989

    • Copp AJ, Brook FA (1989). Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?. J.Med.Genet., 26, 160 - 166.

    1988

    • Copp AJ, Bernfield M (1988). Glycosaminoglycans vary in accumulation along the neuraxis during spinal neurulation in the mouse embryo. DB, 130, 573 - 582.
    • Copp AJ, Crolla JA, Brook FA (1988). Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation. Development., 104, 297 - 303.
    • Copp AJ, Clarke JR (1988). Role of the polar trophectoderm in determining the pattern of early post-implantation morphogenesis in mammals: evidence from development of the short-tailed field vole, Microtus agrestis. Placenta, 9, 643 - 653.
    • Copp AJ, Bernfield M (1988). Accumulation of basement membrane-associated hyaluronate is reduced in the posterior neuropore region of mutant (curly tail) mouse embryos developing spinal neural tube defects. DB, 130, 583 - 590.
    • Copp AJ, Brook FA, Roberts HJ (1988). A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects. Development., 104, 285 - 295.

    1986

    • Copp AJ, Roberts HM, Polani PE (1986). Chimaerism of primordial germ cells in the early postimplantation mouse embryo following microsurgical grafting of posterior primitive streak cells in vitro. JEEM, 95, 95 - 115.

    1985

    • Copp AJ (1985). Relationship between timing of posterior neuropore closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture. JEEM, 88, 39 - 54.

    1983

    • Copp AJ (1983). Teratology and experimental embryology: the pathogenesis of neural tube defects. In Warshaw JB (Ed.), The Biological Basis of Reproductive and Developmental Medicine (pp. 155 - 178). : Elsevier Biomedical.

    1982

    • Copp AJ (1982). Effect of implantational delay on cellular proliferation in the mouse blastocyst. JRF, 66, 681 - 685.
    • Copp AJ, Seller MJ, Polani PE (1982). Neural tube development in mutant (curly tail) and normal mouse embryos: the timing of posterior neuropore closure in vivo and in vitro. JEEM, 69, 151 - 167.
    • Copp AJ (1982). Problems of early embryogenesis. In Jones CT (Ed.), Biochemical Development of the Fetus and Neonate (pp. 3 - 64). : Elsevier Biomedical Press.

    1981

    • Copp AJ (1981). The mechanism of mouse egg-cylinder morphogenesis in vitro. JEEM, 61, 277 - 287.

    1980

    • Copp AJ (1980). The development of field vole (Microtus agrestis) and mouse blastocysts in vitro: a study of trophoblast cell migration. Placenta, 1, 47 - 60.

    1979

    • Copp AJ (1979). Interaction between inner cell mass and trophectoderm of the mouse blastocyst. II. The fate of the polar trophectoderm. JEEM, 51, 109 - 120.

    1978

    • Copp AJ, Rossant J (1978). Effect of implantational delay on transfer of rat embryos to mice. JRF, 52, 119 - 121.
    • Copp AJ (1978). Interaction between inner cell mass and trophectoderm of the mouse blastocyst. I. A study of cellular proliferation. JEEM, 48, 109 - 125.