Prof Alison Lloyd

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Name: Alison Lloyd Email: alison.lloyd@ucl.ac.uk
Title: Prof Tel: 0044 20 7679 2240
Department: MRC/UCL Lab for Molecular Cell Bio Fax:
Position: Professor of Cell Biology Address: University College London, , London, WC1 6BT
Research Domain: Basic Life Sciences, Cancer, Experimental Medicine, Neuroscience, Personalised Medicine, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page:  

Profile

Research Description

Schwann cells are the main glial cells of the peripheral nervous system. Properties of these cells make them a powerful model system for studying two fundamental biological processes: (1) Cell growth (2) Cell regeneration. Using a combination of primary in vitro culture systems and in vivo mouse models we aim to study the molecular and cellular mechanisms underlying the homeostatic regulation of these processes and how they become deregulated in diseases such as cancer. These studies should identify novel pathways important in these processes and new targets for regenerative medicine and cancer therapeutics.

 


Research Activities

Cell Growth and Regeneration

Leukocyte trafficking in tissue damage

Education Description

UCL Collaborators

Prof Ashley Groves; Dr Joanna Porter; Prof David Moores

External Collaborators

Publications

    2013

    • Ribeiro S, Napoli I, White IJ, Parrinello S, Flanagan AM, Suter U, Parada LF, Lloyd AC (2013). Injury Signals Cooperate with Nf1 Loss to Relieve the Tumor-Suppressive Environment of Adult Peripheral Nerve.. Cell Rep, , - . doi:10.1016/j.celrep.2013.08.033
    • Lloyd AC (2013). The regulation of cell size.. Cell, 154(6), 1194 - 1205. doi:10.1016/j.cell.2013.08.053

    2012

    • Roberts SA, Lloyd AC (2012). Aspects of cell growth control illustrated by the Schwann cell.. Curr Opin Cell Biol, 24(6), 852 - 857. doi:10.1016/j.ceb.2012.10.003
    • Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Evans DG, Giancotti F, Hanemann CO, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N (2012). Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta Neuropathol, 123(3), 369 - 380. doi:10.1007/s00401-011-0905-0
    • Collins MJ, Napoli I , Ribeiro S, Roberts S, Lloyd AC (2012). Loss of Rb Cooperates with Ras to Drive Oncogenic Growth in Mammalian Cells.. Current Biology, 22(19), 1765 - 1773.
    • Napoli I, Noon LA, Ribeiro S, Kerai AP, Parrinello S, Rosenberg LH, Collins MJ, Harrisingh MC, White IJ, Woodhoo A, Lloyd AC (2012). A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo.. Neuron, 73(4), 729 - 742. doi:10.1016/j.neuron.2011.11.031

    2011

    • Feber A, Wilson GA, Zhang L, Presneau N, Idowu B, Down TA, Rakyan VK, Noon LA, Lloyd AC, Stupka E, Schiza V, Teschendorff AE, Schroth GP, Flanagan A, Beck S (2011). Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.. Genome Res, 21(4), 515 - 524. doi:10.1101/gr.109678.110

    2010

    • Danovi D, Cremona CA, Machado-da-Silva G, Basu S, Noon LA, Parrinello P, Lloyd AC (2010). A genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin. PLoSONE, 5(7), e11774 - .
    • Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedrova M, Parkinson DB, Doddrell RDS, Nakayama M, Adams RH, Lloyd AC (2010). EphB signalling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell, 143, 145 - 155.

    2009

    • Cremona CA, Lloyd AC (2009). Loss of anchorage in checkpoint-deficient cells increases genomic instability and promotes oncogenic transformation.. J Cell Sci, 122(Pt 18), 3272 - 3281. doi:10.1242/jcs.047126
    • Echave P, Machado-da-Silva G, Arkell RS, Duchen MR, Jacobson J, Mitter R, Lloyd AC (2009). Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis.. Journal of Cell Science, 122(24), 4516 - 4525.
    • Parrinello , Lloyd SA, A C (2009). Neurofibroma development in NF1--insights into tumour initiation.. Trends in Cell Biology, 19(8), 395 - 403.

    2008

    • Rubio D, Garcia S, Paz MF, De LCT, Lopez-Fernandez LA, Lloyd AC, Garcia-Castro J, Bernad A (2008). Molecular characterization of spontaneous mesenchymal stem cell transformation.. PLoS ONE, 3(1), e1398 - .
    • Parrinello S, Noon LA, Harrisingh MC, Wingfield Digby P, Echave P, Cremona CA, Rosenberg LH, Flanagan AM, Parada LF, Lloyd AC (2008). NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F.. Genes and Development, 22(23), 3335 - 3348.
    • Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R, Jessen KR (2008). c-Jun is a negative regulator of myelination. The Journal of Cell Biology, 181(4), 625 - 637. doi:10.1083/jcb.200803013

    2007

    • Rubio D, Garcia S, De LCT, Paz MF, Lloyd AC, Bernad A, Garcia-Castro J (2007). Human mesenchymal stem cell transformation is associated with a mesenchymal-epithelial transition.. Experimental Cell Research, 314(4), 691 - 698.
    • Echave P, Conlon IJ, Lloyd AC (2007). Cell size regulation in mammalian cells.. Cell Cycle, 6(2), 218 - 224.
    • Noon LA, Lloyd AC (2007). Treating Leprosy: an Erb-al remedy?. Trends in Pharmacological Sciences, 28(3), 103 - 105.

    2006

    • Lloyd AC (2006). Distinct functions for ERKs?. Journal of Biology, 5, 13 - .

    2005

    • Rubio D, Garcia-Castro J, Martin MC, de LFR, Cigudosa JC, Lloyd ACABA (2005). Spontaneous human adult stem cell transformation. cancer research, 65(8), 3035 - 3039.
    • Noon LAAL, A C (2005). Hijacking the ERK signaling pathway: Mycobacterium leprae shuns MEK to drive the proliferation of infected Schwann cells.. Science STKE, 309, pe52 - .

    2004

    • Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW, Lloyd AC (2004). The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation.. The EMBO Journal, 23(15), 3061 - 3071. doi:10.1038/sj.emboj.7600309
    • Conlon I, Lloyd AC, Raff MC (2004). Co-ordination of cell growth and cell-cycle progression in proliferating mammalian cells.. In Hall MN, Raff M, Thomas G (Ed.), Cell Growth: Control of Cell Size (pp. 85 - 101). : Cold Spring Harbour Laboratory Press.
    • Perez-Nadales E, Lloyd AC (2004). Essential function for ErbB3 in breast cancer proliferation.. Breast Cancer Research, 6, 137 - 139.
    • Harrisingh MC, Lloyd AC (2004). Ras/Raf/ERK signalling and NF1.. Cell Cycle, 3(10), 1255 - 1258.

    2003

    • Mitchell PJ, Perez-Nadales E, Malcolm DS, Lloyd AC (2003). Dissecting the Contribution of p16 INK4A and the Rb Family to the Ras Transformed Phenotype. Molecular and Cellular Biology, 23(7), 2530 - 2542. doi:10.1128/MCB.23.7.2530-2542.2003

    2002

    • Lloyd AC (2002). Limits to Lifespan. Nature Cell Biology, 4, 0 - 0.
    • Lloyd AC (2002). Limits to lifespan.. Nat Cell Biol, 4(2), E25 - E27. doi:10.1038/ncb0202-e25

    2001

    • Mathon NF, Malcolm DS, Harrisingh MC, Cheng L, Lloyd AC (2001). Lack of replicative senescence in normal rodent glia. Science, 291, 872 - 875. doi:10.1126/science.1056782
    • Mathon NF, Lloyd AC (2001). Cell Senescence and Cancer. Nature Reviews Cancer, 1, 203 - 213.
    • Tang DG, Tokumoto YM, Apperly JA, Lloyd AC, Raff MC (2001). Lack of replicative senescence in cultured oligodendrocyte precursor cells. Science, 291(5505), 868 - 871. doi:10.1126/science.1056780

    2000

    • (2000). p53: Only ARF the story. Nature Cell Biology, 2, 48 - 50.

    1998

    • Lloyd AC (1998). Ras versus cyclin-dependent kinase inhibitors. Current Opinion in Genetics and Development, 8, 43 - 48.

    1997

    • Lloyd AC, Obermuller F, Staddon S, Barth C, McMahon M, Land H (1997). Co-operating Oncogenes Target Cyclin/Cdk Activity. Genes and Development, 11, 663 - 677.
    • Sewing A, Wiseman B, Lloyd AC, Land H (1997). high Intensity Raf Signal Causes Cell-Cycle Arrest Mediated by p21Cip1.. Molecular and Cellular Biology, 17, 5588 - 5597.

    1991

    • Lloyd AC, Yancheva N, Wasylyk B (1991). Transformation suppressor Activity of a Jun transcription Factor Lacking its Activation Domain. Nature, 352, 635 - 638.

    1989

    • Morris JDH, Price B, Lloyd AC, Self AJ, Marshall CJ, Hall A (1989). Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis.. Oncogene, 4, 27 - 31.
    • Lloyd AC, Davies SA, Crossley I, Whitaker M, Houslay MD, Hall A, Marshall CJ, Wakelam MJO (1989). Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene.. Biochemical Journal, 260, 813 - 819.
    • Lloyd AC, Paterson HF, Morris JD, Hall A, Marshall CJ (1989). p21H-Ras Induced Morphological Transformation and Increases in c-myc Expression are Independent of functional Protein kinase C. The EMBO Journal, 8, 1099 - 1104.
    • Flores P, Gutman A, Imler JL, Lloyd AC, Schneikert J, Wasylyk C, Wasylyk B (1989). AP1 and PEA3 are Nuclear targets for Transcriptional Activation by Non-nuclear oncogenes. Hormones and Cell Regulation, 198, 57 - 62.
    • Marshall CJ, Lloyd AC, Morris JD, Paterson H, Price B, Hall A (1989). Signal transduction by p21ras.. International Journal of Cancer - Supplement, 4, 29 - 31.

    1988

    • Hall A, Cales C, Hancock JF, Lloyd AC, Self A, Gardener S, Houslay MD, Wakelam MJ, Marshall CJ (1988). Analysis of mammalian Ras effector function. Cold Spring Harbor Symposium on Quantitative Biology, 53, 855 - 862.

    1986

    • Lloyd AC, Carpenter CA, Saggerson ED (1986). Intertissue differences in the hysteretic behaviour of carnitine palmitoyltransferase in the presence of malonyl-CoA. Biochemical Journal, 237, 289 - 291.

    • NAPOLI I, NOON L, RIBEIRO S, KERAI A, PARRINELLO S, ROSENBERG L, COLLINS M, HARRISINGH M, WHITE I, WOODHOO A, LLOYD A (). A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo. NEURON, , - .