Two new papers published in 2015. One on the arsenite oxidase and its ability to also oxidise antimony (see link) and the other on arsenic mobilisation in West Bengal (see link)

Contact us:

Dr Joanne Santini (Group Leader)

Institute of Structural & Molecular Biology,

University College London,

Darwin Building, Gower Street,

London WC1E 6BT

Email: j.santini@ucl.ac.uk





  • Osborne TH, McArthur JM, Sikdar PK, Santini JM (2015). Isolation of an arsenate-respiring bacterium from a redox front in an arsenic-polluted aquifer in West Bengal, Bengal Basin. Environ. Sci. Technol. 49(7): 4193-4199. Link
  • Wang Q*, Warelow TP*, Kang Y-S, Romano C, Osborne TH, Lehr CR, Bothner B, McDermott TR^, Santini JM^, Wang G^ (2015). Arsenite oxidase also functions as an antimonite oxidase. Appl. Environ. Microbiol. 81(6): 1959-1965. Link * contributed equally ^ corresponding authors


  • Kalimuthu P, Heath MD, Santini JM, Kappler U, Bernhardt PV (2014). Electrochemically driven catalysis of Rhizobium sp. NT-26 arsenite oxidase with its native electron acceptor cytochrome c552. Biochim. Biophys. Acta -Bioenergetics. 1837(1): 112-120. Link
  • Dekker L, Osborne TH, Santini JM (2014). Isolation and identification of cobalt and caesium resistant bacteria from a nuclear fuel storage pond. FEMS Microbiol. Lett. 359(1): 81-84. Link


  • Warelow TP, Oke M, Schoepp-Cothenet B, Dahl JU, Bruselat N, Sivalingam GN, Leimkühler S, Thalassinos K, Kappler U, Naismith JH & Santini JM (2013). The respiratory arsenite oxidase: structure and the role of residues surrounding the Rieske cluster. PLoS One 8(8): e72535. Link
  • Andres J, Arsène-Ploetze F, Barbe V, Brochier-Armanet C, Cleiss-Arnold J, Coppée JY, Dillies MA, Geist L, Joublin A, Koechler S, Lassalle F, Marchal M, Médigue C, Muller D, Nesme X, Plewniak F, Proux C, Ramirez-Bahena MH, Schenowitz C, Sismeiro O, Vallenet D, Santini JM, & Bertin PN (2013). Life in an arsenic-containing gold mine: genome and physiology of the autotrophic arsenite-oxidizing bacterium Rhizobium sp. NT-26. Gen. Biol. Evol. 5(5): 934-953 Link
  • Osborne TH, Heath MD, Martin ACR, Pankowski JA, Hudson-Edwards KA & Santini JM (2013). Cold-adapted arsenite oxidase from a psychrotolerant Polaromonas species. Metallomics 5(4): 318-324. Link
  • Hudson-Edwards KA, Santini JM (2013). Arsenic-microbe-mineral interactions in mining-affected environments. Minerals 3: 337-351. Link


  • van Lis R, Nitschke W, Warelow TP, Capowiez L, Santini JM & Schoepp-Cothenet B (2012). Heterologously expressed arsenite oxidase: A system to study biogenesis and structure/function relationships of the enzyme family. Biochim. Biophys. Acta - Bioenergetics 1817(9): 1701-1708. Link
  • Heath MD, Schoepp-Cothenet B, Osborne TH & Santini JM (2012). Arsenite oxidase, in The Metabolism of Arsenite, eds. Santini JM & Ward SA, CRC press. pp. 81-97. Link
  • Osborne TH & Santini JM (2012). Prokaryotic aerobic oxidation of arsenite, in The Metabolism of Arsenite, eds. Santini JM & Ward SA, CRC press. pp. 61-72. Link
  • Lett MC, Muller D, Lièvremont D, Silver S & Santini JM (2012). Unified nomenclature for genes involved in prokaryotic aerobic arsenite oxidation.  J. Bacteriol. 194(2): 207-208. Link


  • Sardiwal S, Santini JM, Osborne TH & Djordjevic S (2010). Characterization of a two-component signal transduction system that controls arsenite oxidation in the chemolithoautotroph NT-26. FEMS Microbiol. Lett. 313(1): 20-28. Link
  • Osborne TH, Jamieson HE, Hudson-Edwards KA, Nordstrom DK, Walker SR, Ward SA & Santini JM (2010). Microbial oxidation of arsenite in a subartic environment: Diversity of arsenite oxidase genes and identification of a psychrotolerant arsenite oxidiser.  BMC Microbiol. 10(205). Link
  • Duval S, Santini JM, Nitschke W, Hille R, & Schoepp-Cothenet B (2010).  The small subunit AroB of arsenite oxidase: lessons on the [2Fe-2S]-Rieske protein superfamily. J. Biol. Chem. 285(27): 20442-20451. Link
  • Lowe EC, Bydder S, Hartshorne RS, Tape HL, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, Richardson DJ & Butler CS (2010). Quinol-cytochrome c oxidoreductase and cytochrome c4 mediate electron transfer during selenate respiration in Thauera selenatis. J. Biol. Chem. 285(24): 18433-18442. Link


  • Schoepp-Cothenet B, Duval S, Santini JM & Nitschke W (2008).  Comment on "Arsenic (III) fuels anoxygenic photosynthesis in hot spring biofilms from Mono Lake, California". Science 323(5914): 583. Link


  • Dridge EJ, Watts CA, Jepson BJN, Line K, Santini JM, Richardson DJ & Butler CS (2007). Investigation of the redox centres of selenate reductase from Thauera selenatis by electron paramagnetic resonance spectroscopy. Biochem. J. 408(1): 19-28. Link
  • Hoeft SE, Switzer Blum J, Stolz JF, Tabita FR, Witte B, King GM, Santini JM & Oremland RS (2007). Alkalilimnicola ehrlichii sp. nov., a novel arsenite-oxidizing, haloalkaliphilic gammaproteobacterium capable of chemoautotrophic or heterotrophic growth with nitrate or oxygen as the electron acceptor. Int. J. Syst. Evol. Microbiol. 570(3): 504-512. Link
  • Inskeep WP, Macur RE, Hamamura N, Warelow TP, Ward SA & Santini JM (2007). Detection, diversity and expression of aerobic bacterial arsenite oxidase genes. Environ. Microbiol. 9(4): 934-43. Link
  • Male KB, Hrapovic S, Santini JM & Luong JHT (2007). A biosensor for arsenite using arsenite oxidase and multi-walled carbon nanotube modified electrodes. Anal. Chem. 79(20): 7831-7837. Link
  • Santini JM, Kappler U, Ward SA, Honeychurch MJ, vanden Hoven RN & Bernhardt PV (2007). The NT-26 cytochrome c552 and its role in arsenite oxidation. Biochim. Biophys. Acta - Bioenergetics 1767(2): 189-196. Link


  • Bernhardt PV & Santini JM (2006). Protein film voltammetry of arsenite oxidase from the chemolithoautotrophic arsenite-oxidizing bacterium NT-26. Biochemistry 45(9): 2804-2809. Link
  • Lebrun E, Santini JM, Brugna M, Ducluzeau AL, Ouchane S, Schoepp-Cothenet B, Baymann F & Nitschke W (2006). The Rieske protein: a case study on the pitfalls of multiple sequence alignments and phylogenetic reconstruction. Mol. Biol. Evol. 23(6): 1180-1191. Link
  • Stolz JF, Basu P, Santini JM & Oremland RS (2006). Arsenic and selenium in microbial metabolism. Ann. Rev. Microbiol. 60: 107-130. Link


  • Maher MJ, Santini JM, Pickering IJ, Prince RC, Macy JM & George GN (2004). X-ray absorption spectroscopy of selenate reductase. Inorg. Chem. 43(2): 402-404. Link
  • Malasarn D, Saltikov CW, Campbell KM, Santini JM, Hering JG & Newman DK (2004). arrA is a specific marker for As(V)-respiration in the environment. Science 306(5695): 455. Link
  • Santini JM & vanden Hoven RN (2004). Molybdenum-containing arsenite oxidase of the chemolithoautotrophic arsenite oxidizer NT-26. J. Bacteriol. 186(6): 1614-1619. Link
  • Santini JM & Stolz JF (2004). Prokaryotic arsenate and selenate respiration, in Strict and Facultative Anaerobes: Medical and Environmental Aspects, eds. Nakano MM & Zuber P, CRC Press. pp. 239-250.
  • Santini JM, Streimann ICA & vanden Hoven RN (2004). Bacillus macyae sp. nov., an arsenate-respiring bacterium isolated from an Australian gold mine. Int. J. Syst. Evol. Microbiol. 54(6): 2241-2244. Link
  • vanden Hoven RN & Santini JM (2004). Arsenite oxidation by the heterotroph Hydrogenophaga sp. str. NT-14: the arsenite oxidase and its physiological electron acceptor. Biochim. Biophys. Acta - Bioenergetics 1656(2-3): 148-155. Link


  • Macy JM & Santini JM (2002). Unique modes of arsenate respiration by Chrysiogenes arsenatis and Desulfomicrobium sp. str. Ben-RB, in Environmental Chemistry of Arsenic, ed. Frankenberger WT, Marcel Dekker. pp. 297-312.
  • Oremland RS, Hoeft SE, Santini JM, Bano N, Hollibaugh RA & Hollibaugh JT (2002). Anaerobic oxidation of arsenite in Mono Lake water and by a facultative, arsenite-oxidizing chemoautotroph, strain MLHE-1. Appl. Environ. Microbiol. 68(10): 4795-5802. Link
  • Santini JM, vanden Hoven RN, & Macy JM (2002). Characteristics of newly discovered arsenite-oxidizing bacteria, in Environmental Chemistry of Arsenic, ed. Frankenberger WT, Marcel Dekker. pp. 329-342.
  • Santini JM, Sly LI, Wen A, Comrie D, DeWulf-Durand P & Macy JM (2002). New arsenite-oxidizing bacteria isolated from Australian gold-mining environments - phylogenetic relationships. Geomicrobiol. J. 19(1): 67-76. Link
  • Santini JM, Stolz JF & Macy JM (2002). Isolation of a new arsenate-respiring bacterium - physiological and phylogenetic studies. Geomicrobiol. J. 19(1): 41-52. Link


  • Macy JM, Santini JM, Pauling BV, O'Neill A & Sly LI (2000). Two new arsenate/sulfate-reducing bacteria: mechanisms of arsenate reduction. Arch. Microbiol. 173(1): 49-57. Link
  • Santini JM, Sly LI, Schnagl RD & Macy JM (2000). A new chemolithoautotrophic arsenite-oxidizing bacterium isolated from a gold mine: phylogenetic, physiological, and preliminary biochemical studies. Appl. Environ. Microbiol. 66(1): 92-97. Link