Contact us:

Dr Joanne Santini (Group Leader)

Institute of Structural & Molecular Biology,

University College London,

Darwin Building, Gower Street,

London WC1E 6BT

Email: j.santini@ucl.ac.uk





  • Duval S, Santini JM, Lemaire D, Chaspoul F, Russell MJ, Nistchke W, Schoepp-Cothenet B (2016). The H-bond network surrounding the pyranopterins modulates redox cooperativity in the molybdenum-bisPGD cofactor in arsenite oxidase. Biochim. Biophys. Acta - Bioenergetics. 1857: 1353-1362. Link
  • Dekker L, Arsène-Ploetze F, Santini JM (2016). Comparative proteomics of Acidithiobacillus ferrooxidans grown in the presence and absence of uranium. Res. Microbiol. 167(3): 234-239. Link


  • Osborne TH, McArthur JM, Sikdar PK, Santini JM (2015). Isolation of an arsenate-respiring bacterium from a redox front in an arsenic-polluted aquifer in West Bengal, Bengal Basin. Environ. Sci. Technol. 49(7): 4193-4199. Link
  • Wang Q*, Warelow TP*, Kang Y-S, Romano C, Osborne TH, Lehr CR, Bothner B, McDermott TR^, Santini JM^, Wang G^ (2015). Arsenite oxidase also functions as an antimonite oxidase. Appl. Environ. Microbiol. 81(6): 1959-1965. Link * contributed equally ^ corresponding authors


  • Kalimuthu P, Heath MD, Santini JM, Kappler U, Bernhardt PV (2014). Electrochemically driven catalysis of Rhizobium sp. NT-26 arsenite oxidase with its native electron acceptor cytochrome c552. Biochim. Biophys. Acta -Bioenergetics. 1837(1): 112-120. Link
  • Dekker L, Osborne TH, Santini JM (2014). Isolation and identification of cobalt and caesium resistant bacteria from a nuclear fuel storage pond. FEMS Microbiol. Lett. 359(1): 81-84. Link


  • Warelow TP, Oke M, Schoepp-Cothenet B, Dahl JU, Bruselat N, Sivalingam GN, Leimkühler S, Thalassinos K, Kappler U, Naismith JH & Santini JM (2013). The respiratory arsenite oxidase: structure and the role of residues surrounding the Rieske cluster. PLoS One 8(8): e72535. Link
  • Andres J, Arsène-Ploetze F, Barbe V, Brochier-Armanet C, Cleiss-Arnold J, Coppée JY, Dillies MA, Geist L, Joublin A, Koechler S, Lassalle F, Marchal M, Médigue C, Muller D, Nesme X, Plewniak F, Proux C, Ramirez-Bahena MH, Schenowitz C, Sismeiro O, Vallenet D, Santini JM, & Bertin PN (2013). Life in an arsenic-containing gold mine: genome and physiology of the autotrophic arsenite-oxidizing bacterium Rhizobium sp. NT-26. Gen. Biol. Evol. 5(5): 934-953 Link
  • Osborne TH, Heath MD, Martin ACR, Pankowski JA, Hudson-Edwards KA & Santini JM (2013). Cold-adapted arsenite oxidase from a psychrotolerant Polaromonas species. Metallomics 5(4): 318-324. Link
  • Hudson-Edwards KA, Santini JM (2013). Arsenic-microbe-mineral interactions in mining-affected environments. Minerals 3: 337-351. Link


  • van Lis R, Nitschke W, Warelow TP, Capowiez L, Santini JM & Schoepp-Cothenet B (2012). Heterologously expressed arsenite oxidase: A system to study biogenesis and structure/function relationships of the enzyme family. Biochim. Biophys. Acta - Bioenergetics 1817(9): 1701-1708. Link
  • Heath MD, Schoepp-Cothenet B, Osborne TH & Santini JM (2012). Arsenite oxidase, in The Metabolism of Arsenite, eds. Santini JM & Ward SA, CRC press. pp. 81-97. Link
  • Osborne TH & Santini JM (2012). Prokaryotic aerobic oxidation of arsenite, in The Metabolism of Arsenite, eds. Santini JM & Ward SA, CRC press. pp. 61-72. Link
  • Lett MC, Muller D, Lièvremont D, Silver S & Santini JM (2012). Unified nomenclature for genes involved in prokaryotic aerobic arsenite oxidation.  J. Bacteriol. 194(2): 207-208. Link


  • Sardiwal S, Santini JM, Osborne TH & Djordjevic S (2010). Characterization of a two-component signal transduction system that controls arsenite oxidation in the chemolithoautotroph NT-26. FEMS Microbiol. Lett. 313(1): 20-28. Link
  • Osborne TH, Jamieson HE, Hudson-Edwards KA, Nordstrom DK, Walker SR, Ward SA & Santini JM (2010). Microbial oxidation of arsenite in a subartic environment: Diversity of arsenite oxidase genes and identification of a psychrotolerant arsenite oxidiser.  BMC Microbiol. 10(205). Link
  • Duval S, Santini JM, Nitschke W, Hille R, & Schoepp-Cothenet B (2010).  The small subunit AroB of arsenite oxidase: lessons on the [2Fe-2S]-Rieske protein superfamily. J. Biol. Chem. 285(27): 20442-20451. Link
  • Lowe EC, Bydder S, Hartshorne RS, Tape HL, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, Richardson DJ & Butler CS (2010). Quinol-cytochrome c oxidoreductase and cytochrome c4 mediate electron transfer during selenate respiration in Thauera selenatis. J. Biol. Chem. 285(24): 18433-18442. Link


  • Schoepp-Cothenet B, Duval S, Santini JM & Nitschke W (2008).  Comment on "Arsenic (III) fuels anoxygenic photosynthesis in hot spring biofilms from Mono Lake, California". Science 323(5914): 583. Link


  • Dridge EJ, Watts CA, Jepson BJN, Line K, Santini JM, Richardson DJ & Butler CS (2007). Investigation of the redox centres of selenate reductase from Thauera selenatis by electron paramagnetic resonance spectroscopy. Biochem. J. 408(1): 19-28. Link
  • Hoeft SE, Switzer Blum J, Stolz JF, Tabita FR, Witte B, King GM, Santini JM & Oremland RS (2007). Alkalilimnicola ehrlichii sp. nov., a novel arsenite-oxidizing, haloalkaliphilic gammaproteobacterium capable of chemoautotrophic or heterotrophic growth with nitrate or oxygen as the electron acceptor. Int. J. Syst. Evol. Microbiol. 570(3): 504-512. Link
  • Inskeep WP, Macur RE, Hamamura N, Warelow TP, Ward SA & Santini JM (2007). Detection, diversity and expression of aerobic bacterial arsenite oxidase genes. Environ. Microbiol. 9(4): 934-43. Link
  • Male KB, Hrapovic S, Santini JM & Luong JHT (2007). A biosensor for arsenite using arsenite oxidase and multi-walled carbon nanotube modified electrodes. Anal. Chem. 79(20): 7831-7837. Link
  • Santini JM, Kappler U, Ward SA, Honeychurch MJ, vanden Hoven RN & Bernhardt PV (2007). The NT-26 cytochrome c552 and its role in arsenite oxidation. Biochim. Biophys. Acta - Bioenergetics 1767(2): 189-196. Link


  • Bernhardt PV & Santini JM (2006). Protein film voltammetry of arsenite oxidase from the chemolithoautotrophic arsenite-oxidizing bacterium NT-26. Biochemistry 45(9): 2804-2809. Link
  • Lebrun E, Santini JM, Brugna M, Ducluzeau AL, Ouchane S, Schoepp-Cothenet B, Baymann F & Nitschke W (2006). The Rieske protein: a case study on the pitfalls of multiple sequence alignments and phylogenetic reconstruction. Mol. Biol. Evol. 23(6): 1180-1191. Link
  • Stolz JF, Basu P, Santini JM & Oremland RS (2006). Arsenic and selenium in microbial metabolism. Ann. Rev. Microbiol. 60: 107-130. Link


  • Maher MJ, Santini JM, Pickering IJ, Prince RC, Macy JM & George GN (2004). X-ray absorption spectroscopy of selenate reductase. Inorg. Chem. 43(2): 402-404. Link
  • Malasarn D, Saltikov CW, Campbell KM, Santini JM, Hering JG & Newman DK (2004). arrA is a specific marker for As(V)-respiration in the environment. Science 306(5695): 455. Link
  • Santini JM & vanden Hoven RN (2004). Molybdenum-containing arsenite oxidase of the chemolithoautotrophic arsenite oxidizer NT-26. J. Bacteriol. 186(6): 1614-1619. Link
  • Santini JM & Stolz JF (2004). Prokaryotic arsenate and selenate respiration, in Strict and Facultative Anaerobes: Medical and Environmental Aspects, eds. Nakano MM & Zuber P, CRC Press. pp. 239-250.
  • Santini JM, Streimann ICA & vanden Hoven RN (2004). Bacillus macyae sp. nov., an arsenate-respiring bacterium isolated from an Australian gold mine. Int. J. Syst. Evol. Microbiol. 54(6): 2241-2244. Link
  • vanden Hoven RN & Santini JM (2004). Arsenite oxidation by the heterotroph Hydrogenophaga sp. str. NT-14: the arsenite oxidase and its physiological electron acceptor. Biochim. Biophys. Acta - Bioenergetics 1656(2-3): 148-155. Link


  • Macy JM & Santini JM (2002). Unique modes of arsenate respiration by Chrysiogenes arsenatis and Desulfomicrobium sp. str. Ben-RB, in Environmental Chemistry of Arsenic, ed. Frankenberger WT, Marcel Dekker. pp. 297-312.
  • Oremland RS, Hoeft SE, Santini JM, Bano N, Hollibaugh RA & Hollibaugh JT (2002). Anaerobic oxidation of arsenite in Mono Lake water and by a facultative, arsenite-oxidizing chemoautotroph, strain MLHE-1. Appl. Environ. Microbiol. 68(10): 4795-5802. Link
  • Santini JM, vanden Hoven RN, & Macy JM (2002). Characteristics of newly discovered arsenite-oxidizing bacteria, in Environmental Chemistry of Arsenic, ed. Frankenberger WT, Marcel Dekker. pp. 329-342.
  • Santini JM, Sly LI, Wen A, Comrie D, DeWulf-Durand P & Macy JM (2002). New arsenite-oxidizing bacteria isolated from Australian gold-mining environments - phylogenetic relationships. Geomicrobiol. J. 19(1): 67-76. Link
  • Santini JM, Stolz JF & Macy JM (2002). Isolation of a new arsenate-respiring bacterium - physiological and phylogenetic studies. Geomicrobiol. J. 19(1): 41-52. Link


  • Macy JM, Santini JM, Pauling BV, O'Neill A & Sly LI (2000). Two new arsenate/sulfate-reducing bacteria: mechanisms of arsenate reduction. Arch. Microbiol. 173(1): 49-57. Link
  • Santini JM, Sly LI, Schnagl RD & Macy JM (2000). A new chemolithoautotrophic arsenite-oxidizing bacterium isolated from a gold mine: phylogenetic, physiological, and preliminary biochemical studies. Appl. Environ. Microbiol. 66(1): 92-97. Link