Reta Lila Weston Institute
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Our Research

NEURODEGENERATION

We have an active, interdisciplinary programme to study movement disorders, particularly Parkinson’s disease (PD) and the parkinsonian disorders, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).

Our links to the Institute of Neurology, the National Hospital of Neurology and Neurosurgery, and the
Queen Square Brain Bank for Neurological Disorders and Sara Koe PSP Research Centre facilitate the integrated study of movement disorders and neurodegeneration, incorporating clinico-pathological, biochemical, genetic and cell biology approaches.

We have active collaborations with the Department of Molecular Neuroscience (Prof Nick Wood) and the Dementia Research Group (Prof Martin Rossor) and the Neurogenetics Group at the National Institute on Ageing, National Institutes of Health, Bethesda, Maryland.

Our core team consists of clinical research fellows, research nurses, research fellows and technicians. The laboratories at the RLWI are fully equipped for cell biology, biochemistry, neuropathology and genetics work.

STROKE

Research at the RLWI includes clinical programmes for the study of the neurological complications of cardio-pulmonary bypass surgery, hip/knee surgery, renal dialysis and transplantation, including a preliminary study comparing the three techniques of finger palpation, epi-aortic scanning and TOE for detecting atheroma in the aorta.
We are also carrying out clinical trials on stroke prevention treatments, and magnetic resonance scanning in stroke patients. These include involvement in the international carotid stenting study (ICSS, also known as the Carotid and Vertebral Artery Transluminal Angioplasty Study 2 - CAVATAS 2).


Other studies:

  • Impact of obstructive sleep apnoea including the relationship between measures of the severity of sleep apnoea with cognition and the impact of treatment on cognition.
  • Introduction and evaluation of a Rapid Ambulance Protocol for identification of stroke protocol.
  • Examining two forms of myocardial protection, acute anaemia, S100b, ApoE and change in temperature on cognitive outcome in cardiac surgery.
  • Investigations of the influence of changes in physiological variables on biochemical markers of neuronal brain damage and progression after stroke.

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