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NEURODEGENERATION
We have an active, interdisciplinary programme to study movement disorders, particularly Parkinson’s disease (PD) and the parkinsonian disorders, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).
Our links to the Institute of Neurology, the National Hospital of Neurology and Neurosurgery, and the
Queen Square Brain Bank for Neurological Disorders and Sara Koe PSP Research Centre facilitate the integrated study of movement disorders and neurodegeneration, incorporating clinico-pathological, biochemical, genetic and cell biology approaches.
We have active collaborations with the Department of Molecular Neuroscience (Prof Nick Wood) and the Dementia Research Group (Prof Martin Rossor) and the Neurogenetics Group at the National Institute on Ageing, National Institutes of Health, Bethesda, Maryland.
Our core team consists of clinical research fellows, research nurses, research fellows and technicians. The laboratories at the RLWI are fully equipped for cell biology, biochemistry, neuropathology and genetics work.
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STROKE
Research
at the RLWI includes clinical programmes for the study of the
neurological
complications of cardio-pulmonary bypass surgery, hip/knee
surgery, renal
dialysis and transplantation, including a preliminary study
comparing
the three techniques of finger palpation, epi-aortic scanning
and TOE
for detecting atheroma in the aorta.
We are also carrying out clinical trials on stroke prevention
treatments,
and magnetic resonance scanning in stroke patients. These
include involvement
in the international carotid stenting study (ICSS,
also known as the Carotid and
Vertebral
Artery Transluminal Angioplasty Study 2 - CAVATAS 2).
Other studies:
- Impact
of obstructive sleep apnoea including the relationship
between measures
of the severity of sleep apnoea with cognition and the
impact of treatment
on cognition.
-
Introduction and evaluation of a Rapid Ambulance Protocol
for identification
of stroke protocol.
- Examining
two forms of myocardial protection, acute anaemia, S100b,
ApoE and
change in temperature on cognitive outcome in cardiac
surgery.
- Investigations
of the influence of changes in physiological variables on
biochemical
markers of neuronal brain damage and progression after
stroke.
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