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Large trial will assess effectiveness of teaching mindfulness in UK schools

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Paula Kearney, UCL Academy teacher, talking to pupils (from left to right) Patricia Markauskaite, Enaya Ali and Haroon Hussein (credit: Wellcome Trust)

A major study to assess whether mindfulness training for teenagers can improve their mental health launches today, involving researchers from UCL alongside staff and students at the UCL Academy.

Improving treatment for systemic amyloidosis

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Whole body anterior amyloid scans of a patient with systemic amyloidosis, showing abundant amyloid in the liver before treatment and the almost complete absence of amyloid after a single dose of the new anti-SAP antibody.

A potential new approach to treat systemic amyloidosis, invented at UCL and being developed by GlaxoSmithKline (GSK), marks the start of a successful and innovative academic-industry collaboration.

UCL to coordinate £16m project to crack difficult disease areas

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Scientist examines samples under a microscope

UCL has successfully coordinated a £16 million bid to work with the Medical Research Council (MRC), GSK and four other universities to improve scientists’ understanding of inflammatory and fibrotic diseases that present a serious burden to patients.

Landmark 69-year study to provide window into dementia

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Professor Nick Fox and Dr Jonathan Schott

A landmark study that has been following a group of people since their birth in the same week in March 1946 is now turning its focus to the risk factors and early signs of dementia.

UCL top performing university in Horizon 2020

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Horizon 2020

UCL is the best performing university in the first year of the EU funding scheme Horizon 2020, securing a total of €73.2 million over 55 projects, according to an analysis by Research Professional.

Many overweight teenagers do not recognise they are too heavy

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Man on scales

More than a third of overweight or obese teenagers don’t see themselves as being too heavy and think their weight is about right, according to a UCL study published today in the International Journal of Obesity.

Commonly prescribed drugs affect decisions to harm oneself and others

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Pills

Healthy people given the serotonin-enhancing antidepressant citalopram were willing to pay almost twice as much to prevent harm to themselves or others than those given placebo drugs in a moral decision-making experiment at UCL.

Research reveals how the human brain might reconstruct past events

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Hippocampus activity seen when forming event memories

When remembering something from our past, we often vividly re-experience the whole episode in which it occurred. New UCL research funded by the Medical Research Council and Wellcome Trust has now revealed how this might happen in the brain.

Rats 'dream' paths to a brighter future

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Illustration of sleeping rat

When rats rest, their brains simulate journeys to a desired future such as a tasty treat, finds new UCL research funded by the Wellcome Trust and Royal Society.

UCL Academy students become environmental engineers

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UCL Academy students become environmental engineers

144 Year 7 students at UCL Academy have been learning about the waste-energy-food cycle as part of a six-week environmental engineering educational programme led by Dr Aiduan Borrion (UCL Civil, Environmental & Geomatic Engineering), in the first major collaboration between UCL Engineering and UCL Academy.

Climate change threatens to undermine the last half century of health gains

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Climate emergency

The threat to human health from climate change is so great that it could undermine the last fifty years of gains in development and global health, according to a major new UCL-led Commission, published in The Lancet.

‘Core’ immune cells reduce symptoms and spread of flu

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H1N1 influenza virus particles shown in transmission electron micrograph

A four-year study of 1,414 unvaccinated people across England found that 43% of them had immune cells that protected them from symptoms of both seasonal and pandemic influenza, and reduced their chances of shedding the virus by two thirds. The work led by researchers from UCL, Oxford University and Public Health England was funded by the Medical Research Council and Wellcome Trust.

Natural genetic variation gives complete resistance in prion diseases

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Prion protein expressed in E. coli

Researchers at the Medical Research Council’s Prion Unit at UCL have identified a naturally occurring variant of the human prion protein that produces resistance to prion diseases such as Creutzfeldt-Jakob disease (CJD). The findings, published in Nature, could give important insight into other human brain diseases that lead to dementia.

New treatment for polycystic kidney disease

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Small vessels inside a cystic kidney with disorganised vasculature

A new technique for treating polycystic kidney disease has been identified by researchers based at the UCL Institute of Child Health. Published in the Journal of the American Society of Nephrology, the treatment, which involves targeting tiny blood and lymphatic vessels inside the kidneys, is shown to improve renal function and slow progression of disease in mice.

Starting HIV treatment early improves patient outcomes

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Scanning electromicrograph of an HIV-infected H9 T cell

A major international randomised clinical trial has found that HIV-infected individuals have a considerably lower risk of developing AIDS or other serious illnesses if they start taking antiretroviral drugs sooner, when their CD4+ T-cell count—a key measure of immune system health—is higher, instead of waiting until the CD4+ cell count drops to lower levels.

Working with Saracens to monitor concussion in rugby

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Saracens players wear patches in games and training

A team of UCL researchers have joined the ongoing Saracens study for the 2015/16 season, which combines impact sensors with blood samples to determine the effects of concussion on rugby players.

Chemo before surgery benefits patients with advanced ovarian cancer

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Chemotherapy machine

Women with advanced ovarian cancer have fewer side effects and tend to have a better quality of life if given chemotherapy before surgery, according to a Cancer Research UK funded study published in The Lancet.

Missing molecule prevents puberty

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Hormones that trigger puberty in the mouse brain

A molecule important in blood vessel formation and brain wiring is also essential for the onset of puberty, finds new research led by UCL and the University of Milan.

Smoking induces early signs of cancer in cheek swabs

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Ashtray

DNA damage caused by smoking can be detected in cheek swabs, finds research published today in JAMA Oncology. The study provides evidence that smoking induces a general cancer program that is also present in cancers which aren’t usually associated with it – including breast and gynaecological cancers.

New test could identify resistant tuberculosis faster in London

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Mycobacterium tuberculosis

Tuberculosis (TB) disease rates in some parts of London are as high as in Sub-Saharan Africa, and drug-resistant strains are becoming increasingly common. These require specific treatments, and if doctors know that a bug is resistant they can start therapy earlier, often leading to better outcomes.

Starved T cells allow hepatitis B to silently infect liver

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Magnified image of liver sample from Hepatitis B patient showing suppressor cells (brown) approaching T cells (red)

Hepatitis B stimulates processes that deprive the body’s immune cells of key nutrients that they need to function, finds new UCL-led research funded by the Medical Research Council and Wellcome Trust.

New screening technique could pick up twice as many ovarian cancer cases

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Ovarian cancer under the microscope

A new screening method can detect twice as many women with ovarian cancer as conventional strategies, according to the latest results from the largest trial of its kind led by UCL.

Connecting places causes mental maps to merge

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CASA_Tube

Realising how places connect geographically causes local maps in the brain to join, forming one big map which helps with planning future journeys, finds a new UCL study.

Mummified bodies from 18th century Europe found to have multiple tuberculosis infections

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Mycobacterium tuberculosis

Bodies found in a 200 year-old Hungarian crypt have revealed the secrets of how tuberculosis (TB) took hold in 18th century Europe, according to a research team involving UCL scientists.

Emotional problems in schoolgirls rose dramatically over past 5 years

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Young student takes exam

Emotional problems in girls aged 11-13 in England increased by 55% between 2009 and 2014, finds new research from UCL and the Anna Freud Centre. On average, this means that a mixed classroom of 30 children today is likely to contain one more girl with emotional difficulties than a comparable class 5 years ago.

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