Personalised Medicine

Personalised Medicine Events

30 July, 2014 - Lgr5+ stem cells in epithelial renewal and cancer

Time: 17:30:00 - 18:30:00

Organised by UCL Ear Institute

The availability of robust cell-surface markers for identifying and isolating adult stem cells is essential for studying both their normal in-vivo function during tissue renewal and for evaluating their contribution to cancer. We have shown Lgr5, a Wnt target gene expressing a 7-TM receptor that functions as facultative component of the Wnt receptor complex, to selectively mark stem cells in a range of rapidly renewing tissues, including the small intestine, colon, stomach, hair follicle, ovary and developing kidney. Multicolor lineage tracing employing the stem cell-specific Lgr5-CreERT2 line has been used to further dissect how these adult stem cell pools maintain tissue homeostasis and contribute to tissue repair following damage. Targeted in-vivo mutation of the Lgr5+ve adult stem cell pools using the same Lgr5-CreERT2 model has been used to determine the contribution of stem cells to tumor initiation and progression in the gut. A summary of this work will be presented here.

Location: Main Lecture Theatre, UCL Ear Institute, 332 Grays Inn Road, London, WC1X 8EE

Contact: Anne Oliphant



2 September, 2014 - Institute of Clinical Trials and Methodology Launch Event

Time: 14:00:00 - 18:30:00

On 2nd September 2014 an event will be held to launch the Institute, showcasing current work and sharing how the ICTM can support all trials across UCL in the future. The meeting will run from 14:00 to 17:00 and be followed by a drinks reception. The Provost, the Vice-Provost, Health and the Dean of FPHS will speak briefly, with Professor Max Parmar (ICTM Director) and the leading trials experts at UCL providing the main content for the afternoon. A detailed agenda and further information will be circulated nearer the time.

Location: Kennedy Lecture Theatre, Institute Of Child Health, 30 Guilford St, , WC1N 1EH

Contact: Katie Canada-Chwieroth



8 September, 2014 - Otto Wolff Lecture

Time: 13:00:00 - 14:00:00

Organised by UCL Institute of Child Health

Save the date for this Otto Wolff Lecture, which will be given by Professor Dame Sally Davies (Chief Medical Officer & Chief Scientific Adviser, Department of Health). Registration details to follow shortly. About the Otto Wolff Lectures Together, Great Ormond Street Hospital for Children (GOSH) and the UCL Institute of Child Health (UCL ICH) are one of the largest and most famous paediatric centres in the world and our Lecture series reflects this status by show-casing world-class clinical and scientific presentations. The series also recognises one of the great GOSH/ICH Clinical Professors of Paediatrics, Otto Wolff, who maintained an active interest in Paediatrics and attended many of the sessions until his death at the age of 90, in April 2010. The Otto Wolff Lectures are held in the Kennedy Lecture Theatre at the UCL Institute of Child Health, normally on the 2nd Monday of each month at 1.00pm with tea/coffee and cake available beforehand from 12.40pm.

Location: Kennedy Lecture Theatre, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH

Contact: Ash Kotecha