Proteomics and Protein Analysis
UCL Proteomics co-ordinates existing proteomics activities at UCL and is a multi-site proteomics/mass spectrometry centre that now links the current UCL proteomics groups. It provides expertise and facilities in cutting-edge proteomics research.
Biophysical analysis of protein structure and interactions
There are a number of facilities for analysis of protein structure and protein-protein and protein-ligand interactions.
The UCL ChemiBank’s (www.ucl.ac.uk/chemibank/)
aim is to enable small molecule ligand discovery for UCL's research community. The
facility stores complete chemical libraries and compound collections in a
controlled environment. A range of chemoinformatic and biological assay
services is provided for early drug discovery projects and to further existing
projects in lead selection and library design. The first screening project has
been completed with two more in progress. Anyone interested in accessing the
ChemiBank should contact Dave Selwood (firstname.lastname@example.org).
The laboratory for Protein Crystallography, Division of Medicine, provides access to a Bruker Prospector X-ray diffraction system that enables determination of the 3D structure of proteins and their complexes with small molecule ligands. Nanolitre crystallisation robotics and protein production facilities are also available.
Biosciences Molecular Interactions facility
Molecular interactions Facility is based on a well-integrated suite of five
complementary methodologies based on protein purifications, ultracentrifugation,
surface sensor technology, solution scattering equipment at the ESRF and at
ISIS, and molecular modelling. This has enabled us to attract small grants to
maintain the Facility, recruit overseas and UK-based PhD and MRes students,
submit strengthened cross-Faculty grant applications, and provide world-class
scientific underpinning for the diverse range of structural immunology
activities within our group (eg: we were selected for a Paper of the Week at J
Biol Chem earlier this year, and this year we already have 12 publications with
more in progress). We also attract outside paying users from UCL Ophthalmology
and elsewhere in London.
Biacore surface plasmon resonance
Dual polarisation interferometry
Bruker MicroTOF mass spectrometry
Further details about the facility can be found here.
UCL/Birkbeck ISMB Biophysics Centre
The ISMB Biophysics Centre offers facilities in Calorimetry, Kinetics, CD and fluorescence spectroscopy as well as a BiaCore and Analytical ultracentrifuge.
CI/WIBR Scientific Support Services
Page last modified on 18 jun 12 17:24