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Proteomics and Protein Analysis

UCL Proteomics

UCL Proteomics co-ordinates existing proteomics activities at UCL and is a multi-site proteomics/mass spectrometry centre that now links the current UCL proteomics groups. It provides expertise and facilities in cutting-edge proteomics research.

Biophysical analysis of protein structure and interactions

There are a number of facilities for analysis of protein structure and protein-protein and protein-ligand interactions.

UCL ChemiBank

The UCL ChemiBank’s (www.ucl.ac.uk/chemibank/) aim is to enable small molecule ligand discovery for UCL's research community. The facility stores complete chemical libraries and compound collections in a controlled environment. A range of chemoinformatic and biological assay services is provided for early drug discovery projects and to further existing projects in lead selection and library design. The first screening project has been completed with two more in progress. Anyone interested in accessing the ChemiBank should contact Dave Selwood (d.selwood@ucl.ac.uk).

X-ray Diffraction

The laboratory for Protein Crystallography, Division of Medicine, provides access to a Bruker Prospector X-ray diffraction system that enables determination of the 3D structure of proteins and their complexes with small molecule ligands. Nanolitre crystallisation robotics and protein production facilities are also available.

Biosciences Molecular Interactions facility

The Molecular interactions Facility is based on a well-integrated suite of five complementary methodologies based on protein purifications, ultracentrifugation, surface sensor technology, solution scattering equipment at the ESRF and at ISIS, and molecular modelling.  This has enabled us to attract small grants to maintain the Facility, recruit overseas and UK-based PhD and MRes students, submit strengthened cross-Faculty grant applications, and provide world-class scientific underpinning for the diverse range of structural immunology activities within our group (eg: we were selected for a Paper of the Week at J Biol Chem earlier this year, and this year we already have 12 publications with more in progress). We also attract outside paying users from UCL Ophthalmology and elsewhere in London.
Analytical Ultracentrifugation
Biacore surface plasmon resonance
Dual polarisation interferometry
Bruker MicroTOF mass spectrometry

Further details about the facility can be found here.

UCL/Birkbeck ISMB Biophysics Centre

The ISMB Biophysics Centre offers facilities in Calorimetry, Kinetics, CD and fluorescence spectroscopy as well as a BiaCore and Analytical ultracentrifuge.

CI/WIBR Scientific Support Services

BiaCore

Mass Spectrometry

HPLC and FPLC


Page last modified on 18 jun 12 17:24