UCL School of Pharmacy
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- Master of Pharmacy (MPharm)
- MSc in Clinical Pharmacy, International Practice and Policy
- MSc in Drug Delivery
- MSc in Drug Discovery and Development
- MSc in Drug Discovery and Pharma Management
- MSc in Pharmacognosy
- MSc Experimental Pharmacology and Therapeutics
- Master of Research (MRes)
- Pharmacy Practice (PG Dip/MSc)
- Certificate in Medicines Management for Pharmacy Technicians
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The MSc programme is designed to allow participants to gain a broad overview of the pipeline of drug discovery and development.
The degree programme outlines the molecular basis of disease and the identification and validation of drug targets. It investigates the various approaches to the identification of lead compounds and their development into active drug candidates. The degree exposes students to modern platforms for drug discovery and methods of drug synthesis and includes lectures from industry-based scientists and visits to industrial and biotechnological research laboratories. Students gain hands-on experience of molecular modeling and computer-based drug design, and analytical and synthetic techniques. The approach of the pharmaceutical industry to pre-clinical development, clinical pharmacology, clinical trials, marketing, licensing and regulatory affairs form an integral part of the drug development process that is studied.
In the second term students choose to study specialist modules such as Anticancer Personalised Medicines, Pharmacogenomics, Adverse Drug Reactions & Biomarkers, New Drug Targets in the Central Nervous System and Advanced Structure-Based Drug Design. The degree culminates in a laboratory research project chosen in one of these areas and can be carried out in the research laboratories of the School of Pharmacy or as an extramural placement in industry.
Include hands-on experience of computer-based drug design, chemical synthesis, extraction of natural products, HPLC, protein purification and gel electrophoresis, enzyme-based bioassay, clinical biochemistry.
PHAYG029 The Process of Drug Discovery and Clinical Development 1 (30 credits)
PHAYG030 The Process of Drug Discovery and Clinical Development 2 (30 credits)
These two core modules span the first and second terms. They follow the process of drug discovery and development and introduce the basis of the pharmaceutical industry through examining previous successes and current methods of drug discovery. The modules include:
Introduction to the molecular basis of disease, identification and validation of drug targets
History of Drug Discovery and Identification of Lead Compounds
Advances in Synthetic Chemistry and Combinatorial Chemistry
Bioassays and High Throughput Screening of Compound Libraries
Molecular Modeling and Structure-Based Drug Design
Physiochemical Properties of Drugs (Absorption, Distribution, Metabolism)
Preclinical Drug Development
Clinical Pharmacology and Toxicology
Regulatory Affairs, Commercial Affairs and Intellectual Property
PHAYG057 Medicinal Chemistry (30 credits)
This module comprises two key elements:
- Modern Aspects of Drug Design: Includes examples of drug discovery such as: beta blockers, antibiotics, biopharmaceuticals, PDE inhibitors, inhibitors of protein-protein interactions in cancer therapy, enzymes as drug targets, biopharmaceuticals, membrane proteins as drug targets.
- Pharmaceutical Analysis: Analytical techniques used in drug discovery include: HPLC, uv-vis spectroscopy, infra-red spectroscopy, NMR, mass spectrometry, electrophoresis, immunochemistry, statistical analysis.
In the second term students choose two of the following specialist modules to study along with the core module:
PHAYG025 Anticancer Personalised Medicines (15 credits)
PHAYG023 New Drug Targets in the Central Nervous System (15 credits)
PHAYG028 Pharmacogenomics, Adverse Drug Reactions and Biomarkers (15 credits)
PHAYG032 Advanced Structure Based Drug Design (15 credits)
Visit to a Leading Pharmaceutical Company
Students visit a leading research laboratory. This is usually an all-day visit to a company such as GlaxoSmithKline, where students look at computer-based molecular modeling, how physico-chemical properties are determined, the robotic compound library, high through put screening, and the chemistry and biology labs. The visit is supplemented by the provision of material and instruction, as well as lectures, to assist understanding of drug discovery and development. The discovery process of a drug will be worked through in detail.
One-day Research Conference
Students attend a one-day research conference in an aspect of drug discovery and development organised by the Society for Medicines Research. Here they will have a chance to interact with leading industrialists and researchers in the field.
Page last modified on 07 nov 13 08:32