UCL School of Pharmacy

UCL School of Pharmacy

• Pharmacy HOME
• About the School
• Study Here
• Research Themes
• Student Life
• International students
• Alumni
• Library and Services
• Research Departments
  • The Director's Office
  • Department of Pharmaceutical & Biological Chemistry
  • Department of Pharmacology
  • Department of Pharmaceutics
  • Department of Practice and Policy
  • Administration
  • Library and Information Services
• Work Here
• Contact Us

Basit Group publications

2011

M.A. Alhnan, S. Murdan, A.W. Basit. "Encapsulation of poorly soluble basic drugs into enteric microparticles: A novel approach to enhance their oral bioavailability" Int J Pharm (2011), In press

A.C. Freire, A.W. Basit, R. Choudhary, C.W. Piong, H.A. Merchant. "Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery" Int J Pharm (2011) 415:15-28

D.A. Ashiru, K. Karu, M. Zloh, R. Patel, A.W. Basit. "Relative quantification of polyethylene glycol 400 excreted in the urine of male and female volunteers by direct injection electrospray-selected ion monitoring mass spectrometry." Int J Pharm (2011) 414:35-41

A.B. Buanz, M.H. Saunders, A.W. Basit, S. Gaisford. "Preparation of Personalized-dose Salbutamol Sulphate Oral Films with Thermal Ink-Jet Printing." Pharm Res (2011), In press

M.A. Alhnan and A.W. Basit. "In-process crystallization of acidic drugs in acrylic microparticle systems: Influence of physical factors and drug-polymer interactions" J Pharm Sci (2011) 100:3284-93

M.A. Alhnan, E. Kidia, A.W. Basit. "Spray-drying enteric polymers from aqueous solutions: A novel, economic, and environmentally friendly approach to produce pH-responsive microparticles" Eur J Pharm Biopharm (2011), In press

D.A. Ashiru, N. Patel, B. Forbes, R. Patel, A.W. Basit. "The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers" Int J Pharm (2011) 409:164-8

F. Liu, H.A. Merchant, R.P. Kulkarni, M. Alkademi, A.W. Basit. "Evolution of a physiological pH 6.8 bicarbonate buffer system: Application to the dissolution testing of enteric coated products" Eur J Pharm Biopharm (2011), 78:151-7

M.A. Alhnan and A.W. Basit. "Engineering polymer blend microparticles: An investigation into the influence of polymer blend distribution and interaction." Eur J Pharm Sci (2011) 42: 30-6

H.A. Merchant, E.L. McConnell, F. Liu, C. Ramaswamy, R.P. Kulkarni, A.W. Basit and S. Murdan. "Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development." Eur J Pharm Sci (2011) 42: 3-10

2010

M.A. Alhnan, D. Cosi, S. Murdan and A.W. Basit. "Inhibiting the gastric burst release of drugs from enteric microparticles: the influence of drug molecular mass and solubility." J Pharm Sci (2010) 99: 4576-83.

H.M. Fadda, M. Khanna, J.C. Santos, D. Osman, S. Gaisford, A.W. Basit. "The use of dynamic mechanical analysis (DMA) to evaluate plasticization of acrylic polymer films under simulated gastrointestinal conditions." Eur J Pharm Biopharm (2010) 76: 493-7.

H.M. Fadda, T. Sousa, A.S. Carlsson, B. Abrahamsson, J.G. Williams, D. Kumar, and A.W. Basit. "Drug Solubility in Luminal Fluids from Different Regions of the Small and Large Intestine of Humans." Mol Pharm.(2010) 7:1527-32

F. Liu, and A.W. Basit. "A paradigm shift in enteric coating: achieving rapid release in the proximal small intestine of man." J Control Release (2010) 147: 242-5.

F.J. Varum, H.M. Merchant, A.W. Basit. Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption. Int. J. Pharm. (2010) 395: 26-36

F.J. Varum, F. Veiga, J.S. Sousa, A.W. Basit. An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig. Eur. J. Pharm. Sci. (2010) 40: 335-341

F. Liu, P Moreno, A.W. Basit. A novel double-coating approach for improved pH-triggered delivery to the ileo-colonic region of the gastrointestinal tract. Eur. J. Pharm. Biopharm. (2010) 74: 311-315

2009

H.M. Fadda, H.A. Merchant, B.T. Arafat, A.W. Basit. Physiological bicarbonate buffers: stabilisation and use as dissolution media for modified release systems. Int. J. Pharm (2009) 382: 56-60

E.L. McConnell, C.B. Macfarlane, A.W. Basit. An observational study on the influence of solvent composition on the architecture of drug-layered pellets. Int J Pharm (2009) 380: 67-71

E.L. McConnell, F. Liu, A.W. Basit. Colonic treatments and targets: issues and opportunities. J Drug Target (2009) 17:335-363

S. Nilkumhang, M.A. Alhnan, E.L. McConnell, A.W. Basit. Drug distribution in enteric microparticles. Int J Pharm (2009) 379:1-8

E.L. McConnell, C.B. Macfarlane and A.W. Basit. An observational study on the influence of solvent composition on the architecture of drug-layerd pellets. Int J. Pharm (2009) 380:67-71

S. Nikumhang, A.W. Basit. The robustness and flexibility of an emulsion solvent evaporation method to prepare pH-responsive microparticles. Int J Pharm (2009) 377(1-2): 135-141

R.A. Kendall, M.A. Alhnan, S. Nilkumhang, S. Murdan, A.W. Basit. Fabrication and in vivo evaluation of highly pH responsive acrylic microparticles for targeted gastrointestinal delivery. Eur J Pharm Sci (2009) 37(3-4):284-290

F. Liu, R. Lizio, C. Meier, H.U. Petereit, P. Blakely, A.W. Basit. A novel concept in enteric coating: a double coating system providing rapid drug release in the proximal small intestine.

A.W. Basit, M.D. Short, E.L. McConnell. Microbiota-triggered colonic delivery: robustness of the polysaccharide approach in the fed state in man. J. Drug Target (2009) 17(1):64-71

F. Liu, R. Lizio, V.J. Schneider, H.U. Petereit, P. Blakey, A.W. Basit. SEM/EDX and confocal microscopy analysis of novel and conventional enteric coated systems. Int. J. Pharm (2009) 369(1-2):72-8

M. McGirr, M. McAllister, E.E. Peters, A.W. Vickers, A.F. Parr, A.W. Basit. The Use of the Intelisite Companion device to delivery mucoadhesive polymers to the dog colon. Eur. J. Pharm. Sci (2009) 36(4-5):386-91

H.M. Fadda, E.L. McConnell, M.D. Short, A.W. Basit. Meal-induced acceleration of tablet transit through the human small intestine. Pharm. Res (2009) 26(2):356-60

2008

E.L. McConnell, H.M. Fadda, A.W. Basit. Gut instincts: Explorations in intestinal physiology and drug delivery. Int. J. Pharm (2008) 364(2):213-26

T. Sousa, R. Paterson, V. Moore, A. Carlsson, B. Abrahamsson, A.W. Basit. The gastrointestinal microbiota as a site for the biotransformation of drugs. Int. J. Pharm (2008) 363: 1-25.

V.C. Ibekwe, M.K. Khela, D.F. Evans, A.W. Basit. A new concept in colonic targeting: a combined pH-responsive and bacterially-triggered drug delivery technology. Aliment Pharmacol. Ther. (2008) 28: 911-916.

F.J. Varum, E.L. McConnell, J.J. Sousa, F. Veiga, A.W. Basit. Mucoadhesion and the gastrointestinal tract. Crit. Rev. Ther. Drug. Carrier Syst. (2008) 25: 207-258.

D.A. Ashiru, R. Patel, A.W. Basit. Polyethylene Glycol 400 Enhances the Bioavailability of a BCS Class III Drug (Ranitidine) in Male Subjects but Not Females. Pharm. Res. (2008) 25:1828-35.

E. Mwesigwa, A.W. Basit, G. Buckton. Moisture sorption and permeability characteristics of polymer films: Implications for their use as barrier coatings for solid dosage forms containing hydrolyzable drug substances. J. Pharm. Sci. (2008) 97:4433-45.

E.L. McConnell, M.D. Short, A.W. Basit, An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man. J. Control. Release (2008) 130: 154-60.

V.C. Ibekwe, H.M. Fadda, E.L. McConnell, M.K. Khela, D.F. Evans, A.W. Basit. Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems. Pharm. Res. (2008) 25: 1828-1835.

E.L. McConnell, S. Murdan, A.W. Basit. An investigation into the digestion of chitosan (non-crosslinked and crosslinked) by human colonic bacteria. J. Pharm. Sci. (2008) 97: 3820-3829.

E.L. McConnell, A.W. Basit, S. Murdan. Measurements of rat and mouse gastrointestinal pH fluid and lymphoid tissue, and implications for in-vivo experiments. J. Pharm. Pharmacol. (2008) 60: 63-70.

H.M. Fadda, M.A. Mohamed, A.W. Basit. Impairment of the in vitro drug release behaviour of oral modified release preparations in the presence of alcohol. Int. J. Pharm (2008) 360: 171-176.

E.L. McConnell, A.W. Basit, S. Murdan. Colonic antigen administration induces significantly higher humoral levels of colonic and vaginal IgA, and serum IgG compared to oral administration. Vaccine (2008) 26: 639-646.

F.J.O. Varum, A.W. Basit, J.J. Sousa, F. Veiga. Mucoadhesion studies in the gastrointestinal tract to increase oral drug bioavailability. Braz J Pharm Sci (2008) 44, 535-548.

H.M. Fadda, M.C. Hernandez, D.N. Margetson, S.M. McAllister, A.W. Basit, S. Brocchini, N. Suarez. The molecular interactions that influence the plasticizer dependent dissolution of acrylic polymer films. J. Pharm. Sci (2008) 97: 3957-3971.

E.L McConnell, A.W Basit. Targeting the colon using COLAL: a novel bacteria-sensitive drug delivery system. In: Modified Release Drug Delivery Technology. M.J. Rathbone, M.S. Roberts (Eds) (2008) pp 354-358.

R.A Kendall, E.L McConnell, S. Murdan, A.W Basit. A novel microparticle technology for tailored drug release in the gastrointestianl tract. In: Modified Release Drug Delivery Technology. M.J. Rathbone, M.S. Roberts (Eds) (2008) pp 555-561.

2007

C. Tuleu, M.K. Khela, D.F. Evans, B.E. Jones, S. Nagata, A.W. Basit, A scintigraphic investigation of the disintegration behaviour of capsules in fasting subjects: a comparison of hypromellose capsules containing carrageenan as a gelling agent and standard gelatin capsules. Eur J Pharm Sci(2007) 30:251-255.

E.L. McConnell, J. Tutas, M.A.M. Mohamed, D. Banning, A.W. Basit, Colonic drug delivery using amylose films: the role of aqueous ethylcellulose dispersions in controlling drug release. Cellulose (2007) 14: 25-34.

D.A.I. Ashiru, R. Patel, A.W. Basit, Simple and universal HPLC-UV method to determine cimetidine, ranitidine, famotidine and nizatidine in urine: Application to the analysis of ranitidine and its metabolites in human volunteers. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences (2007) 860: 235-240.

2006

J.D.R. Schulze, D.A.I. Ashiru, M.K. Khela, D.F. Evans, R. Patel, G.E. Parsons, M.D. Coffin, A.W. Basit, Impact of formulation excipients on human intestinal transit. J Pharm Pharmacol (2006) 58: 821-825.

V.C. Ibekwe, F. Liu, H.M. Fadda, M.K. Khela, D.F. Evans, G.E. Parsons, A.W. Basit, An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans. J Pharm Sci (2006) 95: 2760-2766.

V.C. Ibekwe, H.M. Fadda, G.E. Parsons, A.W. Basit, A comparative in vitro assessment of the drug release performance of pH-responsive polymers for ileo-colonic delivery. Int J Pharm (2006) 308: 52-60.

R.A. Kendall, A.W. Basit. The role of polymers in solid oral dosage forms. In: I.F. Ichegbu, A.G. Schatzlein (Eds) Polymers and Drug Delivery (2006) pp 35-48

2005

P.J. Wilson, A.W. Basit, Exploiting gastrointestinal bacteria to target drugs to the colon: An in vitro study using amylose coated tablets. Int J Pharm (2005) 300: 89-94.

J.D.R. Schulze, E.E. Peters, A.W. Vickers, J.S. Staton, M.D. Coffin, G.E. Parsons, A.W. Basit, Excipient effects on gastrointestinal transit and drug absorption in beagle dogs. Int J Pharm (2006) 300: 67-75.

A.W Basit. Advances in colonic drug delivery. Drugs (2005) 65: 1991-2007

R.A. Kendall, S. Murdan, A.W. Basit. Modified-release microparticle for oral drug delivery. Drug Del Tech (2005) 5: 76-80

P.J Wilson, A.W. Basit. Exploiting gastrointestinal bacteria to target drugs to the colon: an in vitro study using amylose coated tablets. Int J Pharm (2005) 300: 89-94

J.D.R Schulze, G.E. Parsons, E.E. Peters, J.S. Staton, M.D. Coffin, A.W. Basit. Excipient effects on gastrointestinal transit and drug absorption in beagle dogs. Int J Pharm. (2005) 300: 67-75

E. Mwesigwa, G. Buckton, A.W. Basit. They hygroscopicity of moisture barrier film coatings. Drug Dev Ind Pharm (2005) 31: 959-968

H.M. Fadda, A.W Basit. Gastrointestinal tract: obstacles or opportunities in drug targeting? Pharm (2005) 1: 52-59

H.M. Fadda, A.W Basit. Dissolution of pH-responsive formulations in media resembling intestinal fluids: bicarbonate versus phosphate buffers. J Drug Del Sci Tech (2005) 15: 273-279

Pre-2005

V.C. Ibekwe, R.A. Kendall, A.W. Basit. Drug delivery to the colon. The Drug Delveries Companies Report. (2004) 17-20

A.W. Basit, F. Podczeck, J.M. Newton, W.A. Waddington, P.J. Ell, L.F. Lacy. The use of formulation technology to assess regional gastrointestinal drug absorption in humans. Eur J Pharm Sci (2004) 179-189

L.F. Siew, S.M Man, J.M. Newton, A.W Basit. Amylose formulations for drug delivery to the colon: a comparison of two fermentation models to assess colonic targeting performance in vitro. Int J Pharm. (2004) 129-134

T.M Lewis, A.W Basit. Re-evaluation of gastrointestinal pH data: ramifications for oral delivery. Pharm Tech (2004) 28: 25-31

A.W. Basit, J.R. Bloor. Perspecitive on colonic drug delivery. Pharma Tech (2003) 185-190

J.D.R Schulze, W.A. Waddington, P.J. Ell, G.E. Parsons, M.D. Coffin, A.W. Basit. Concentration-dependent effects of polyethylene glycol 400 on gastrointestinal transit and drug absorption. Pharmaceutical Research (2003) 20: 1984-1988

A.W. Basit, Lacey L.F. Susceptibility of H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora. Int J Pharm. (2002) 237: 23-33

A.W. Basit, F Podczeck, J.M Newton, W.A. Waddington, P.L Ell, Lacey L.F. Influence of polyethylene glycol 400 on the gastrointestinal absorption of ranitidine. Pharm Res (2002) 19: 1365-1371

C Tuleu, A.W. Basit, W.A Waddington, P.J. Ell, J.M Newton, Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose coated hydroxypropylmethylcellulose capsules. Alimentary Pharmacology and Therapeutics (2002) 16: 1771-1779

C.W. Leong, J.M. Newton, A.W. Basit, F. Podczeck, S.G. Ring, J.H. Cummings. The formation of colonic digestible films of amylose and ethylcellulose from aqueous dispersions at temperature below 37oC. Eur J Pharm Biopharm (2002) 54: 291-297

A.W. Basit, J.M. Newton, M.D. Short, W.A. Waddington, P.J. Ell, L.F. Lacey. The effect of polyethylene glycol 400 on gastrointestinal transit: implications for the formualtion of poorly water-soluble drugs. Pharm Res (2001) 18: 1146-1150

A.W. Basit. Oral colon-specific drug delivery using amylose-based film coatings. Pharm Tech Europe (2000) 12: 30-36

L.F Siew, A.W. Basit, J.M. Newton. The properties of amylose-ethylcellulose films cast from organic-based solvents as potental coatings for colonic drug delivery. Eur J Pharm Sci (2000) 11: 133-139

L.F. Siew, A.W Basit, J.M. Newton. The potential of organic-based amylose-ethylcellulose film coatings as oral colon-specific drug delivery systems. AAPS PharmSciTech 1(3) article 22 (http://www.aapspharmscitech.org) (2000).

A.W. Basit. Colon-targeted drug delivery. PharmaTech (2000) 166-170

A.W. Basit, J.M Newton, L.F. Lacey, Formulation of ranitidine pellets by extrusion-spheronization with little or no microcrystalline cellulose. Pharm Dev Tech. (1999) 4: 499-505