Essentials of Pharmaceutical Preformulation
A book by Dr Simon Gaisford, Course Director MSc in Drug Delivery
Essentials of Pharmaceutical Preformulation is a study guide which
describes the basic principles of pharmaceutical physicochemical
characterisation. Successful preformulation requires knowledge of fundamental
molecular concepts (solubility, ionisation, partitioning, hygroscopicity and
stability) and macroscopic properties (physical form, such as the crystalline
and amorphous states, hydrates, solvates and co-crystals and powder
properties), familiarity with the techniques used to measure them and
appreciation of their effect on product performance, recognising that often
there is a position of compromise to be reached between product stability and
bioavailability. This text introduces the basic concepts and discusses
their wider implication for pharmaceutical development, with reference to many
case examples of current drugs and drug products. Special attention is given to
the principles and best-practice of the analytical techniques that underpin
preformulation (UV spectrophotometry, TLC, DSC, XRPD and HPLC).
The book is available in both hard and soft binding and is available in UCL School of Pharmacy Library. The website link is: www.wiley.com/buy/978-0-470-97636-4
Page last modified on 23 mar 13 10:56
