THIN Database Research Team
The Health Improvement Network (THIN) database is a large UK primary care database. The THIN Database Research Team uses this database, containing data collected from over 550 general practitioners spread over the UK, for research into cardiovascular disease, mental health, pharmacoepidemiology and other fields of primary care research (publications).
Photo: Stata programs for outlier identification in THIN.
NEXT SEMINAR: Tuesday 10th May, 3.30pm-5pm
At our next seminar, Jens Sundbøll and Jayati Das-Munshi will talk about their work investigating associations between mental and physical illness. Jens Sundbøll will present on Impact of Preadmission Depression on Mortality following Myocardial Infarction: A study using Danish registry data, and Jayati Das-Munshi will present on Type 2 diabetes mellitus in severe mental illness; inequalities by ethnicity and age: cross-sectional analysis from the UK. Further details of our seminars can be found here.
Updated 03/05/16 | Seminars
PUBLICATION: psychotropic medication in pregnancy
A Health Technology Assessment report has been published on the risks and benefits of psychotropic medication in pregnancy.
Updated 04/04/16 | Publications
PUBLICATION: recording and treatment of premenstrual syndrome
Cormac Sammon and colleagues have published a paper in BMJ Open on the recording and treatment of premenstrual syndrome in UK general practice.
Updated 22/03/16 | Publications
PUBLICATION: monitoring of alcohol consumption in adults with bipolar disorder
Sarah Hardoon and colleagues have published a paper in the Journal of Affective Disorders on the monitoring of alcohol consumption in primary care among adults with bipolar disorder.
Updated 22/03/16 | Publications
PUBLICATION: antidepressant use in children and adolescents
A paper has been published in European Neuropsychopharmacology on trends in antidepressant use in children and adolescents in the UK, Denmark, Germany, the Netherlands, and the United States. This study has been featured on the UCL website, and has also received extensive press coverage, including BBC News and The Independent.
Updated 10/03/16 | Publications
PUBLICATION: living with an older person dying from cancer, COPD, or dementia
A paper on health outcomes in cohabitees of people dying with cancer, COPD, or dementia has been published in the Journal of Pain and Symptom Management. This research has received some press coverage.
Updated 10/03/16 | Publications
PUBLICATION: censoring at date of last data collection
Cormac Sammon and Irene Petersen have published a paper in Pharmacoepidemiology and Drug Safety exploring the effect of censoring at the date of last data collection in primary care database studies. They suggest that data should be censored prior to the last data collection date in order to avoid underestimation of event rates.
Updated 19/02/16 | Publications
PUBLICATION: SSRIs and congenital heart anomalies
Irene Petersen and colleagues have published a paper in the Journal of Clinical Psychiatry on SSRIs and congenital heart anomalies. Using THIN data, they performed a study of the risk of congenital heart abnormalities in four cohorts of children of women who had differing exposures to antidepressants before and during pregnancy. They found no increased risk of heart anomalies in children born to women on antidepressants. An article on this study can be found on the UCL News website.
Updated 28/01/16 | Publications
PUBLICATION: prevalence of pregestational diabetes in pregnancy
PhD student Sonia Coton has published a paper on trends in the prevalence of pregestational diabetes in pregnancy recorded in UK general practice during 1995-2012.
Updated 26/01/16 | Publications
PUBLICATION: incidence, prevalence and prescribing trends in type 2 diabetes
PhD student Manuj Sharma has published a paper on trends in incidence, prevalence and prescribing in type 2 diabetes. This study highlights the significant increase in type 2 diabetes prevalence and incidence observed in the UK over the past decade mapping how it has becomes such a significant public health burden. It also describes how medical management of the disease has evolved: demonstrating how metformin has become the most commonly prescribed first-line and second line add-on treatment option but also how more novel treatments have been prescribed in primary care.
Updated 15/01/2016 | Publications
PUBLICATION: deprivation and access to anti-dementia drugs in the UK
A paper has been published in Age and Ageing on deprivation and the prescribing of anti-dementia drugs. This study has received some press coverage in The Daily Mail and The Mirror. A blog post on the study has been published. The study has also been highlighted by UCL News.
Updated 24/11/2015 | Publications
PUBLICATION: recurrence of boils or abscesses
Laura Shallcross and colleagues have published a paper in the British Journal of General Practice on recurrent infection in those consulting a GP for a boil or abscess.
Updated 27/10/2015 | Publications
PUBLICATION: RECORD statement
A paper has been published in PLoS Medicine on The REporting of studies Conducted using Observational Routinely collected health Data (RECORD) statement, which was created as an extension to the STROBE statement to address reporting items specific to observational studies using routinely collected health data. Further information can be found on the RECORD statement website. Irene Petersen is a member of the RECORD Group steering committee.
Updated 05/10/2015 | Publications
PUBLICATIONS: studies on influenza using THIN
Pia Hardelid and colleagues have recently published two studies on influenza using THIN data. Their paper in PLoS ONE is on the recording of influenza-like illness in primary care, and their paper in Epidemiology & Infection is on the prescribing of neuraminidase inhibitors for influenza in primary care.
Updated 29/09/2015 | Publications
PUBLICATION: changes in blood pressure after glucocorticoid therapy initiation
Laurence Fardet and colleagues have published a paper in The Journal of Clinical Endocrinology and Metabolism on longitudinal variations in blood pressure before and after initiation of synthetic glucocorticoid therapy.
Updated 28/05/2015 | Publications
PUBLICATION: recording of drug use and opioid substitute treatment in primary care
Hilary Davies and colleagues have published a paper in PLoS ONE on trends of recording of drug use and opioid substitute treatment in primary care.
Updated 05/05/2015 | Publications
PUBLICATION: monitoring of patients on glucocorticoid therapy
Laurence Fardet and colleagues have published a paper in Medicine on the monitoring provided to patients receiving long-term systemic glucocorticoids.
Updated 21/04/2015 | Publications
PUBLICATION: lithium prescribing during pregnancy
Rachel McCrea and colleagues have published a paper in PLoS ONE on lithium prescribing during pregnancy. They found that pregnancy was strongly associated with discontinuation of lithium.
Updated 08/04/2015 | Publications
PUBLICATION: antibiotic prescribing in pregnancy and cerebral palsy or epilepsy in children
Wilhelmine Meeraus and colleagues have published a paper in PLoS ONE on the association between antibiotic prescribing in pregnancy and cerebral palsy or epilepsy in children. This study has received some media coverage and been discussed on the NHS Choices 'Behind The Headlines' site.
Updated 30/03/2015 | Publications
PUBLICATION: regional differences in the initiation of statin therapy
Aidan O'Keeffe and colleagues have published a paper in BMJ Open on regional differences in the initiation of statin therapy for the primary prevention of cardiovascular disease. They found that the rate of statin initiation varied between the four countries of the UK, and between the different English regions.
Updated 17/03/2015 | Publications
PUBLICATION: an incentivised scheme to provide annual health checks in primary care for adults with intellectual disability
A paper assessing the first three years of an incentivised scheme to provide annual health checks in primary care for adults with intellectual disability has been published in The Lancet Psychiatry. This has received some media coverage.
Updated 05/01/2015 | Publications
PUBLICATION: CVD risk models for people with severe mental illness
Updated 24/12/2014 | Publications
PUBLICATION: prescribing of antipsychotics in primary care
Louise Marston and colleagues have published a paper in BMJ Open on the prescribing of antipsychotics in UK primary care. The study, which found that a large proportion of antipsychotic prescriptions were for people with no record of a psychotic or bipolar diagnosis, has also received some media coverage.
Updated 19/12/2014 | Publications
PUBLICATION: prediagnostic presentation of Parkinson's disease
Updated 27/11/2014 | Publications
BLOG POST: ICPE conference
Hilary Davies has written a post for the NIHR School for Primary Care Research blog on her recent visit to Taipei for The International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE).
Page last modified on 03 may 16 15:15 by Rebecca K Lodwick