THIN Database Research Team


The Health Improvement Network (THIN) database is a large UK primary care database. The THIN Database Research Team uses this database, containing data collected from over 550 general practitioners spread over the UK, for research into cardiovascular disease, mental health, pharmacoepidemiology and other fields of primary care research (publications). 

Stata programs for outlier identification in THIN running on 'The Beast'

Photo: Stata programs for outlier identification in THIN.


PUBLICATION: SSRIs and congenital heart anomalies

Irene Petersen and colleagues have published a paper in the Journal of Clinical Psychiatry on SSRIs and congenital heart anomalies. Using THIN data, they performed a study of the risk of congenital heart abnormalities in four cohorts of children of women who had differing exposures to antidepressants before and during pregnancy. They found no increased risk of heart anomalies in children born to women on antidepressants. An article on this study can be found on the UCL News website.  

Updated 28/01/16 | Publications


PUBLICATION: prevalence of pregestational diabetes in pregnancy

PhD student Sonia Coton has published a paper on trends in the prevalence of pregestational diabetes in pregnancy recorded in UK general practice during 1995-2012.

Updated 26/01/16 | Publications


PUBLICATION: incidence, prevalence and prescribing trends in type 2 diabetes

PhD student Manuj Sharma has published a paper on trends in incidence, prevalence and prescribing in type 2 diabetes. This study highlights the significant increase in type 2 diabetes prevalence and incidence observed in the UK over the past decade mapping how it has becomes such a significant public health burden. It also describes how medical management of the disease has evolved: demonstrating how metformin has become the most commonly prescribed first-line and second line add-on treatment option but also how more novel treatments have been prescribed in primary care. 

Updated 15/01/2016 | Publications


PUBLICATION: deprivation and access to anti-dementia drugs in the UK

A paper has been published in Age and Ageing on deprivation and the prescribing of anti-dementia drugs. This study has received some press coverage in The Daily Mail and The Mirror. A blog post on the study has been published. The study has also been highlighted by UCL News.

Updated 24/11/2015 | Publications

PUBLICATION: recurrence of boils or abscesses

Laura Shallcross and colleagues have published a paper in the British Journal of General Practice on recurrent infection in those consulting a GP for a boil or abscess. 

Updated 27/10/2015 | Publications

PUBLICATION: RECORD statement

A paper has been published in PLoS Medicine on The REporting of studies Conducted using Observational Routinely collected health Data (RECORD) statement, which was created as an extension to the STROBE statement to address reporting items specific to observational studies using routinely collected health data. Further information can be found on the RECORD statement website. Irene Petersen is a member of the RECORD Group steering committee.

Updated 05/10/2015 | Publications

PUBLICATIONS: studies on influenza using THIN

Pia Hardelid and colleagues have recently published two studies on influenza using THIN data. Their paper in PLoS ONE is on the recording of influenza-like illness in primary care, and their paper in Epidemiology & Infection is on the prescribing of neuraminidase inhibitors for influenza in primary care.

Updated 29/09/2015 | Publications

PUBLICATION: changes in blood pressure after glucocorticoid therapy initiation

Laurence Fardet and colleagues have published a paper in The Journal of Clinical Endocrinology and Metabolism on longitudinal variations in blood pressure before and after initiation of synthetic glucocorticoid therapy.

Updated 28/05/2015 | Publications

PUBLICATION: recording of drug use and opioid substitute treatment in primary care

Hilary Davies and colleagues have published a paper in PLoS ONE on trends of recording of drug use and opioid substitute treatment in primary care.

Updated 05/05/2015 | Publications

PUBLICATION: monitoring of patients on glucocorticoid therapy

Laurence Fardet and colleagues have published a paper in Medicine on the monitoring provided to patients receiving long-term systemic glucocorticoids.

Updated 21/04/2015 | Publications

PUBLICATION: lithium prescribing during pregnancy

Rachel McCrea and colleagues have published a paper in PLoS ONE on lithium prescribing during pregnancy. They found that pregnancy was strongly associated with discontinuation of lithium.

Updated 08/04/2015 | Publications

PUBLICATION: antibiotic prescribing in pregnancy and cerebral palsy or epilepsy in children

Wilhelmine Meeraus and colleagues have published a paper in PLoS ONE on the association between antibiotic prescribing in pregnancy and cerebral palsy or epilepsy in children. This study has received some media coverage and been discussed on the NHS Choices 'Behind The Headlines' site.  

Updated 30/03/2015 | Publications

PUBLICATION: regional differences in the initiation of statin therapy

Aidan O'Keeffe and colleagues have published a paper in BMJ Open on regional differences in the initiation of statin therapy for the primary prevention of cardiovascular disease. They found that the rate of statin initiation varied between the four countries of the UK, and between the different English regions.

Updated 17/03/2015 | Publications

PUBLICATION: an incentivised scheme to provide annual health checks in primary care for adults with intellectual disability

A paper assessing the first three years of an incentivised scheme to provide annual health checks in primary care for adults with intellectual disability has been published in The Lancet Psychiatry. This has received some media coverage.

Updated 05/01/2015 | Publications

PUBLICATION: CVD risk models for people with severe mental illness

A paper on risk models for predicting cardiovascular events in people with severe mental illness has been published in JAMA Psychiatry. This work forms part of the PRIMROSE project

Updated 24/12/2014 | Publications

PUBLICATION: prescribing of antipsychotics in primary care

Louise Marston and colleagues have published a paper in BMJ Open on the prescribing of antipsychotics in UK primary care. The study, which found that a large proportion of antipsychotic prescriptions were for people with no record of a psychotic or bipolar diagnosis, has also received some media coverage

Updated 19/12/2014 | Publications

PUBLICATION: prediagnostic presentation of Parkinson's disease

A paper on presentation of prediagnostic features in primary care prior to diagnosis with Parkinson's disease has been published in The Lancet Neurology, with an accompanying commentary.

Updated 27/11/2014 | Publications

BLOG POST: ICPE conference

Hilary Davies has written a post for the NIHR School for Primary Care Research blog on her recent visit to Taipei for The International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE).

Updated 24/11/2014

Page last modified on 28 jan 16 14:48 by Rebecca K Lodwick