Seminar Details

Is the new genetics fulfilling its promise? A perspective on cardiovascular disease
Thursday, 17th November 2011
1pm - 2pm (12.45 for sandwiches)
Seminar Room 2, PCPH, Upper 3rd Floor, UCL (Royal Free Campus)
Speaker: Prof. Richard Morris
Details: When the human genome project approached completion around the turn of the millenium, there were high hopes for an era of personalised medicine: not only would prediction of lifetime risk for various diseases be possible, but doctors would be able to administer treatment tailored to a patient's genetic profile. Enormous research activity has followed, in particular Genome Wide Association Studies which attempt to identify genes influencing specific diseases. More focussed research has followed in the form of Mendelian Randomisation studies, sometimes dubbed "Nature's randomised trials": these have attempted to elicit causal pathways to disease. Following such work, some have attempted to quantify the ability to predict risk of cardiovascular disease based on "gene scores". The British Regional Heart Study (BRHS) has contributed to some of the above endeavours by use of DNA extracted from blood samples of around 4000 British men. However BRHS is too small to elicit reliable information on its own, hence a consortium of around 12 cohort studies including the BRHS has formed, based at UCL. I will describe the current state of play in finding new causal pathways for cardiovascular disease, and the ability to predict individual risk.

Page last modified on 01 nov 11 22:51 by Rushmi Pelpola