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- Editorial praises CORU's simple risk stratification model
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- We're recruiting! Applications invited for Research Associate and Senior Research Associate vacancies
Editorial praises CORU's simple risk stratification model
25 May 2011
CORU's recent work with Papworth Hospital, developing a
simple stratification scheme for identfying patients at risk of
excessive post-operative bleeding has been published in the European
Journal of Cardio-thoracic Surgery (EJCTS)1. The work was discussed in an editorial for EJCTS2
where we were praised for the effort that went into the score and for
its easy-to-use nature, facilitating its potential use across several
Severe post-operative bleeding can lead to adverse outcomes for cardiac surgery patients and is a relatively common complication of cardiac surgery. One of the most effective drugs to prevent such bleeding, aprotinin, has been withdrawn from the market due to concerns over its safety. Alternative prophylactic drugs which can be given to patients to prevent bleeding can result in significant side effects and are expensive. For this reason it is difficult to make a clinical or economic case for administering these drugs to all cardiac surgery patients, and the prevailing view is that their use should be targeted at patients considered to be at relatively high risk of post-operative bleeding. However, there is currently no objective method for identifying such patients. Together with clinicians at Papworth Hospital, we devised a risk stratification scheme that could potentially be used to identify a cohort of higher risk patients. Such patients could be treated with the available prophylactic drugs or recruited to studies to evaluate new interventions.
1. Vuylsteke A, Pagel C, Gerrard C, Reddy B, Nashef S, Utley M, The Papworth Bleeding Risk Score: a stratification scheme for identifying cardiac surgery patients at risk of excessive early postoperative bleeding, European Journal of Cardiothoracic Surgery, 39:924-930, 2011.
2. Editorial comment on The Papworth Bleeding Risk Score: a stratification scheme for identifying cardiac surgery patients at risk of excessive early postoperative bleeding, Anders Jeppsson, European Journal of Cardiothoracic Surgery, 39:930-931, 2011.