Autonomic Neuroscience and Metabolic Disease

Dr Stefan Trapp

Reader in Autonomic Neuroscience and Metabolic Disease

Centre for Cardiovascular and Metabolic Neuroscience

422, Rockefeller Building, Bloomsbury Campus, UCL London WC1E

Tel: 0207 679 6094 (internal ext 46094)

Centre for Cardiovascular and Metabolic Neuroscience Website

Lab Members

Dr Simon C. Cork

Dr James Richards

Miss Marie Holt

External Collaborators

Prof Fiona Gribble (Cambridge)

Prof Ida Llewellyn-Smith (Flinders University, Australia)

Dr Frank Reimann (Cambridge)

Prof Guy Rutter (Imperial)

Dr Diana Williams (Florida State University, USA)

Prof Bill Wisden (Imperial)


The research in our lab aims at a greater understanding of the role of the brain in metabolic disease, particularly diabetes mellitus, obesity, and co-morbidities such as autonomic dysfunction and cardiovascular disease. Supported primarily by the MRC and recently also the EFSD and Diabetes UK, we are using transgenic models combined with pharmacogenetics, and a combination of molecular, optical, immunocytochemical and electrophysiological techniques to address these questions in vitro and in vivo. Over the years our work has been concerned with metabolic regulation of neuronal excitability under physiological and pathophysiological conditions. This ranges from the mechanisms underlying ischemic and anaesthetic preconditioning, via molecular mechanisms of glucosensing in the vagal nucleus, to the role of glucagon-like-peptide (GLP)-1 secreting neurones in the brainstem.

Current Projects (Enquiries by prospective PhD or Project Students are always welcome)

· Autonomic dysfunction and Diabetes mellitus

· Glucose-sensing cells in the autonomic nervous system

· The role of glucagon-like-peptide 1 in the central nervous system

· Role of 'background' 2-pore domain K+ channels in the autonomic nervous system 

Trapp 2 research image

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